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EGF Gene

protein-coding   GIFtS: 72
GCID: GC04P110834

Epidermal Growth Factor

(Previous name: epidermal growth factor (beta-urogastrone))
  See EGF-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Epidermal Growth Factor1 2
HOMG42 5
URG2 5
Epidermal Growth Factor (Beta-Urogastrone)1
beta-urogastrone2
Pro-Epidermal Growth Factor2

External Ids:    HGNC: 32291   Entrez Gene: 19502   Ensembl: ENSG000001387987   OMIM: 1315305   UniProtKB: P011333   

Export aliases for EGF gene to outside databases

Previous GC identifers: GC04P111240 GC04P111104 GC04P111292 GC04P111191 GC04P106566


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for EGF Gene:
This gene encodes a member of the epidermal growth factor superfamily. The encoded protein is synthesized as a
large precursor molecule that is proteolytically cleaved to generate the 53-amino acid epidermal growth factor
peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation
and differentiation of numerous cell types. This protein acts by binding the high affinity cell surface receptor,
epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of
this gene has been associated with the growth and progression of certain cancers. Alternate splicing results in
multiple transcript variants.(provided by RefSeq, May 2010)

GeneCards Summary for EGF Gene:
EGF (epidermal growth factor) is a protein-coding gene. Diseases associated with EGF include renal hypomagnesemia 4, and angiomatous meningioma. GO annotations related to this gene include epidermal growth factor receptor binding and calcium ion binding. An important paralog of this gene is LRP6.

UniProtKB/Swiss-Prot: EGF_HUMAN, P01133
Function: EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some
fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal
convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6

summary for EGF Gene:
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase of the ErbB family. Four members
of the ErbB family have been identified; EGFR (ErbB1, HER1), ErbB2 (HER2), ErbB3 (HER3) and ErbB4 (HER4).
EGFR signaling is initiated by ligand binding to the extracellular ligand binding domain. This initiates
receptor homo-/hetero-dimerization and autophosphorylation by the intracellular kinase domain, resulting in
receptor activation. Following activation, phosphorylation of cytoplasmic substrates occurs and a signaling
cascade is initiated that drives many cellular responses, including changes in gene expression, cytoskeletal
rearrangement, anti-apoptosis and increased cell proliferation.

Gene Wiki entry for EGF (Epidermal growth factor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the EGF gene promoter:
         STAT5B   STAT1   AP-1   ATF-2   STAT5A   CREB   deltaCREB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEGF promoter sequence
   Search Chromatin IP Primers for EGF

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EGF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q25   Ensembl cytogenetic band:  4q25   HGNC cytogenetic band: 4q25

EGF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EGF gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P110834:  view genomic region     (about GC identifiers)

Start:
110,834,040 bp from pter      End:
110,934,118 bp from pter
Size:
100,079 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: EGF_HUMAN, P01133 (See protein sequence)
Recommended Name: Pro-epidermal growth factor precursor  
Size: 1207 amino acids; 133994 Da
Subunit: Interacts with EGFR and promotes EGFR dimerization. Interacts with RHBDF2 (By similarity). Interacts with
RHBDF1; may retain EGF in the endoplasmic reticulum and regulates its degradation through the endoplasmic
reticulum-associated degradation (ERAD)
Sequence caution: Sequence=AAR84237.1; Type=Erroneous gene model prediction;
6 PDB 3D structures from and Proteopedia for EGF:
1IVO (3D)        1JL9 (3D)        1NQL (3D)        1P9J (3D)        2KV4 (3D)        3NJP (3D)    
Secondary accessions: B4DRK7 E7EVD2 E9PBF0 Q52LZ6
Alternative splicing: 3 isoforms:  P01133-1   P01133-2   P01133-3   (No experimental confirmation available. Gene prediction based on cDNA data)

Explore the universe of human proteins at neXtProt for EGF: NX_P01133

Explore proteomics data for EGF at MOPED

Post-translational modifications: 

  • O-glycosylated with core 1-like and core 2-like glycans. It is uncertain if Ser-954 or Thr-955 is O-glycosylated.
    The modification here shows glycan heterogeneity: HexHexNAc (major) and Hex2HexNAc2 (minor)1
  • Glycosylation2 at Asn38, Asn104, Asn117, Asn148, Asn324, Asn404, Asn596, Asn815, Asn926, Ser954,
                                 Thr955
  • Modification sites at PhosphoSitePlus

  • See EGF Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001171601.1  NP_001171602.1  NP_001954.2  

    ENSEMBL proteins: 
     ENSP00000424316   ENSP00000265171   ENSP00000421384  
    Reactome Protein details: P01133

    EGF Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant EGF Protein
    R&D Systems Recombinant & Natural Proteins for EGF
    Enzo Life Sciences proteins for EGF
    OriGene Purified Protein for EGF
    OriGene Protein Over-expression Lysate for EGF
    OriGene MassSpec for EGF
    OriGene Custom Protein Services for EGF
    GenScript Purified and Recombinant Proteins for EGF
    Novus Biologicals EGF Proteins
    Novus Biologicals EGF Lysates
    Sino Biological Recombinant Protein for EGF
    Sino Biological Cell Lysate for EGF
    ProSpec Recombinant Protein for EGF
    Cloud-Clone Corp. Proteins for EGF

     
    eBioscience Proteins for EGF:  
                        Recombinant Human EGF 500 ug

    EGF Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of EGF
    R&D Systems Antibodies for EGF
    Cell Signaling Technology (CST) Antibodies for EGF 
    OriGene Antibodies for EGF
    OriGene Custom Antibody Services for EGF
    Novus Biologicals EGF Antibodies
    Abcam antibodies for EGF
    Cloud-Clone Corp. Antibodies for EGF
    ThermoFisher Antibody for EGF
    LSBio Antibodies in human, mouse, rat for EGF

    EGF Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for EGF
    R&D Systems Flow Cytometry Kits for EGF         (see all)
    GenScript Custom Assay Services for EGF
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for EGF
    Cloud-Clone Corp. CLIAs for EGF
    eBioscience ELISAs for EGF:  
                        Human EGF Instant ELISA 128 tests


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 10):
     IPR000033 LDLR_classB_rpt
     IPR016317 Pro-epidermal_GF
     IPR001881 EGF-like_Ca-bd_dom
     IPR000742 EG-like_dom
     IPR011042 6-blade_b-propeller_TolB-like

    Graphical View of Domain Structure for InterPro Entry P01133

    ProtoNet protein and cluster: P01133

    4 Blocks protein domains:
    IPB000033 Low-density lipoprotein receptor
    IPB000152 Aspartic acid and asparagine hydroxylation site
    IPB001336 Type I EGF signature
    IPB001881 EGF-like calcium-binding


    UniProtKB/Swiss-Prot: EGF_HUMAN, P01133
    Similarity: Contains 9 EGF-like domains
    Similarity: Contains 9 LDL-receptor class B repeats


    Find genes that share domains with EGF           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EGF_HUMAN, P01133
    Function: EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some
    fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal
    convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6

         Genatlas biochemistry entry for EGF:
    epidermal growth factor,6kDa,synthesized as a large preprotein,EGF membrane glycoprotein also containing nine EGF
    repeats and urogastrone

         Summary: 
    During embryonic development, EGF as signaling molecule affects the following cells:
    Eye: Late Retinal Progenitor Cells (Corneal Epithelium), Fetal Corneal Basal Epithelial Cells (Retinal Neuroblastic Layer)       to see all 2 cells
    Placenta: Villous Cytotrophoblast Cells (Chorion Frondosum), Primitive Cytotrophoblast Cells (Chorionic Villus)       to see all 2 cells

    EGF as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
          selected tissues (see all 14)      fully expand
    Brain: Oligodendrocyte-like cells, Caudal astrospheres      fully expand to see all 8 cells
    Pancreas: Pancreatic endocrine/exocrine-like cells, Expanded pancreatic progenitor cells      fully expand to see all 4 cells

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005154epidermal growth factor receptor binding TAS15611079
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI12297050
    GO:0008083growth factor activity IDA15611079
    GO:0030297transmembrane receptor protein tyrosine kinase activator activity TAS9712850
         
    Find genes that share ontologies with EGF           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for EGF:
     Decreased p24 protein expressi  Increased Salmonella enterica  

         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Egf):
     digestive/alimentary  endocrine/exocrine gland  growth/size/body  immune system  integument 
     normal  reproductive system  vision/eye 

    Find genes that share phenotypes with EGF           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Egftm1Dle for EGF

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EGF
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for EGF

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EGF
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EGF

    miRNA
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    Block miRNA regulation of human, mouse, rat EGF using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate EGF:
    hsa-miR-33a* hsa-miR-3163 hsa-miR-576-5p hsa-miR-145 hsa-miR-590-3p hsa-miR-3182
    SwitchGear 3'UTR luciferase reporter plasmidEGF 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for EGF
    Predesigned siRNA for gene silencing in human, mouse, rat EGF

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for EGF

    Clone
    Products:
         
    OriGene clones in human, mouse for EGF (see all 15)
    OriGene ORF clones in mouse, rat for EGF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: EGF (NM_001945)
    Sino Biological Human cDNA Clone for EGF
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EGF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EGF

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for EGF
    Browse ESI BIO Cell Lines and PureStem Progenitors for EGF 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EGF

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12279 VA6-13291) for EGF 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EGF_HUMAN, P01133: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    plasma membrane4
    endoplasmic reticulum2
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0005765lysosomal membrane IDA17897319
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with EGF           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for EGF About   (see all 77)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1ErbB signaling pathway
    ErbB signaling pathway0.52
    EGFR Inhibitor Pathway, Pharmacodynamics0.49
    ErbB signaling pathway0.52
    ErbB receptor signaling network0.00
    2Development EGFR signaling pathway
    Development EGFR signaling pathway0.57
    EGF Pathway0.39
    Development ERBB family signaling0.57
    3Ca-dependent events
    EGFR interacts with phospholipase C-gamma0.94
    Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling0.33
    PLCG1 events in ERBB2 signaling0.92
    4Focal adhesion
    Focal adhesion0.65
    Focal Adhesion0.65
    5Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57


    Find genes that share SuperPaths with EGF           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for EGF (see all 67)
        Molecular Mechanisms of Cancer
    eIF2 Pathway
    Intracellular Calcium Signaling
    JNK Pathway
    ERK5 Signaling

    1 Cell Signaling Technology (CST) Pathway for EGF
        Tyrosine Kinases / Adaptors

    Selected GeneGo (Thomson Reuters) Pathways for EGF (see all 14)
        Transcription Androgen Receptor nuclear signaling
    Development EGFR signaling pathway
    Development EGFR signaling via small GTPases
    Translation Regulation of EIF2 activity
    Signal transduction PTEN pathway

    Selected BioSystems Pathways for EGF (see all 23)
        MAPK signaling pathway
    MicroRNAs in cardiomyocyte hypertrophy
    Focal Adhesion
    TGF Beta Signaling Pathway
    EGFR1 Signaling Pathway

    1 Sino Biological Pathway for EGF
        EGFR Signaling Pathway

    Selected Reactome Pathways for EGF (see all 16)
        EGFR downregulation
    Signaling by ERBB2
    GAB1 signalosome
    Platelet degranulation
    GRB2 events in ERBB2 signaling

    1 PharmGKB Pathway for EGF
        EGFR Inhibitor Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for EGF) (see all 21):
        MAPK signaling pathway
    ErbB signaling pathway
    Ras signaling pathway
    Rap1 signaling pathway
    Cytokine-cytokine receptor interaction

        Pathway & Disease-focused RT2 Profiler PCR Arrays including EGF (see all 14): 
              Osteogenesis in human mouse rat
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Neurogenesis in human mouse rat
              Nephrotoxicity in human mouse rat
              Growth Factors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for EGF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for EGF (P011331, 2, 3 ENSP000002651714) via UniProtKB, MINT, STRING, and/or I2D (see all 156)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EGFRP005331, 2, 3, ENSP000002754934EBI-640857,EBI-297353 MINT-8146350 MINT-8146425 MINT-25095 MINT-8146487 MINT-8146461 MINT-8146623 MINT-8146300 MINT-8146514 MINT-8146500 MINT-8146380 MINT-8146287 MINT-6169912 I2D: score=6 STRING: ENSP00000275493
    S100A4P264472, 3, ENSP000003462944MINT-7256556 I2D: score=1 STRING: ENSP00000346294
    ERBB2P046263, ENSP000002695714I2D: score=3 STRING: ENSP00000269571
    LMNAP025453, ENSP000003572834I2D: score=2 STRING: ENSP00000357283
    MAPKAPK2P491373, ENSP000003560704I2D: score=1 STRING: ENSP00000356070
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 37):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000186activation of MAPKK activity IEA--
    GO:0001525angiogenesis IDA15611079
    GO:0002576platelet degranulation TAS--
    GO:0006260DNA replication TAS9482941
    GO:0007165signal transduction TAS--

    Find genes that share ontologies with EGF           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for EGF
    Selected ApexBio Compounds for EGF (see all 31)     About this table
    CompoundAction CAS #
    AC480 (BMS-599626)orally bioavailable inhibitor of the HER1, HER2 and HER4[714971-09-2]
    AEE788 (NVP-AEE788)novel multitargeted HER 1/2 and VEGFR 1/2[497839-62-0]
    Afatinib (BIBW2992)Irreversible EGFR and HER2 inhibitor[439081-18-2]
    AG-18Inhibits EGFR,PDGFR[118409-57-7]
    AG-490inhibitor of EGFR[133550-30-8]
    AP26113Dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR)[1197958-12-5]
    ARRY-380orally bioavailable inhibitor of the human EGFR tyrosine kinase ErbB-2[937265-83-3]
    AZD8931 (Sapitinib)ATP competitive and reversible inhibitor of EGFR (ErbB-1), Neu (ErbB-2) and ErbB-3[848942-61-0]
    BMS-690514potent and selective inhibitor of epidermal growth factor receptor (EGFR), HER2, and HER4[859853-30-8]
    Buteina reversible, ATP-competitive, selective, and highly potent inhibitor of PI 3-kinase beta[487-52-5]

    Compounds for EGF available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Iressa Orally active, selective EGFR inhibitor [184475-35-2]
    AG 490 EGFR-kinase inhibitor. Also JAK2, JAK3 inhibitor [133550-30-8]
    JNJ 28871063 hydrochloridePotent ErbB receptor family inhibitor[944341-54-2]
    AG 1478 hydrochlorideHighly potent EGFR-kinase inhibitor[153436-53-4]
    GenisteinEGFR kinase inhibitor. Also estrogen and PPARgamma ligand[446-72-0]

    2 HMDB Compounds for EGF    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    MagnesiumMagnesium (see all 2)7439-95-4--

    2 DrugBank Compounds for EGF    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Alpha-Aminobutyric Acid-- --target--17139284 17016423 10592235
    Sucralfate-- 54182-58-0targetinducer1957124 1970337 8578218

    Selected Novoseek inferred chemical compound relationships for EGF gene (see all 133)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 89.9 1884 1689318 (6), 14642088 (6), 1801683 (6), 11459228 (5) (see all 99)
    ag 1478 89.1 95 10579343 (2), 12580917 (2), 12141529 (2), 10766877 (2) (see all 77)
    pd153035 81.2 16 9815602 (2), 11169460 (2), 11792073 (1), 19423651 (1) (see all 14)
    gefitinib 78.8 158 15083203 (6), 17311025 (4), 18691415 (4), 19380191 (4) (see all 74)
    thymidine 74.8 290 7507605 (6), 1311246 (4), 8687119 (3), 8319182 (3) (see all 99)
    cetuximab 74.6 79 18691415 (5), 19380191 (4), 17707800 (3), 12850474 (2) (see all 51)
    phosphatidylinositol 73.6 219 7515147 (5), 9886492 (4), 10801833 (4), 16728406 (3) (see all 99)
    phosphotyrosine 73.3 57 10634619 (2), 1693615 (1), 7661200 (1), 8081876 (1) (see all 48)
    pd 98,059 70.1 84 11277615 (2), 17107667 (2), 10395291 (2), 17283879 (2) (see all 63)
    vegf 69.9 648 15690202 (10), 12667326 (7), 15250102 (7), 9626350 (5) (see all 99)

    1 PharmGKB related drug/compound annotation for EGF gene    About this table
    Drug/compound PharmGKB Annotation
    cetuximabCA  



    Find genes that share compounds with EGF           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for EGF gene (3 alternative transcripts): 
    NM_001178130.1  NM_001178131.1  NM_001963.4  

    Unigene Cluster for EGF:

    Epidermal growth factor
    Hs.419815  [show with all ESTs]
    Unigene Representative Sequence: NM_001963
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000509793 ENST00000265171(uc003hzy.4 uc011cfu.2 uc011cfv.2 uc010imk.3)
    ENST00000503392 ENST00000502723 ENST00000504633 ENST00000502579 ENST00000541061
    ENST00000511228 ENST00000509996 ENST00000544918 ENST00000537316 ENST00000540840

    miRNA
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    Block miRNA regulation of human, mouse, rat EGF using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate EGF:
    hsa-miR-33a* hsa-miR-3163 hsa-miR-576-5p hsa-miR-145 hsa-miR-590-3p hsa-miR-3182
    SwitchGear 3'UTR luciferase reporter plasmidEGF 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for EGF
    Predesigned siRNA for gene silencing in human, mouse, rat EGF
    Clone
    Products:
         
    OriGene clones in human, mouse for EGF (see all 15)
    OriGene ORF clones in mouse, rat for EGF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: EGF (NM_001945)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EGF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EGF
    Primer
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    OriGene qPCR primer pairs and template standards for EGF
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    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12279 VA6-13291) for EGF 

    Additional mRNA sequence: 

    AK299306.1 AK307734.1 AY548762.1 BC093731.1 BC113461.1 BC143357.1 JQ346088.1 X04571.1 

    8 DOTS entries:

    DT.303224  DT.95252684  DT.100018040  DT.100751605  DT.91987341  DT.92032313  DT.95158066  DT.92051525 

    Selected AceView cDNA sequences (see all 65):

    AW772286 AI381567 BE501422 AA954947 AY548762 BG460205 BG461309 NM_001963 
    AW300103 BG459705 CD679255 BG460186 BM090870 X04571 BG459974 BG461800 
    BM090637 BG461255 BG460092 BX485552 BG460854 AI769680 BX280823 BG427221 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EGF expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGGCAGGAG
    EGF Expression
    About this image


    EGF expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Anterior neural specified EBs
     
     Epithelial Cells
             Inner Enamel Epithelial Cells Dental Enamel
     
     Epidermis (Integumentary System)    fully expand to see all 2 entries
             Detroit 551
     
     Trophoblast (Extraembryonic Tissues)    fully expand to see all 2 entries
             Zygote Zygote
     
     Zygote (Early Embryonic Tissues)    fully expand to see all 2 entries
             Zygote Zygote
    EGF Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EGF Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.419815

    UniProtKB/Swiss-Prot: EGF_HUMAN, P01133
    Tissue specificity: Expressed in kidney, salivary gland, cerebrum and prostate

        Pathway & Disease-focused RT2 Profiler PCR Arrays including EGF (see all 14): 
              Osteogenesis in human mouse rat
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Neurogenesis in human mouse rat
              Nephrotoxicity in human mouse rat
              Growth Factors in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for EGF gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Egf1 , 5 epidermal growth factor1, 5 76.73(n)1
    67.48(a)1
      3 (58.50 cM)5
    136451  NM_010113.31  NP_034243.21 
     1296775755 
    chicken
    (Gallus gallus)
    Aves EGF1 epidermal growth factor 65.75(n)
    55.4(a)
      408035  NM_001001292.1  NP_001001292.1 
    lizard
    (Anolis carolinensis)
    Reptilia EGF6
    epidermal growth factor
    48(a)
    1 ↔ 1
    5(144288193-144337195)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia egf1 epidermal growth factor 58.85(n)
    49.03(a)
      100127663  NM_001113007.1  NP_001106478.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.271302 Danio rerio epidermal growth factor precursor (egf) more 76.93(n)    AY332224.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta LRP16
    yl6
    yolkless
    6(a)
    11(a)
    many ↔ many
    many ↔ many
    2R(4061670-4113943)
    X(14087252-14093996)
    worm
    (Caenorhabditis elegans)
    Secernentea lrp-26
    egg-26
    (see all 5)
    Protein EGG-2 (egg-2) mRNA, complete cds
    (see all 5)
    7(a)
    18(a)
    (see all 5)
    many ↔ many
    many ↔ many
    (see all 5)
    I(3935269-3953942) WBGene00003072
    III(7058518-7060597) WBGene00019811


    ENSEMBL Gene Tree for EGF (if available)
    TreeFam Gene Tree for EGF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for EGF gene
    LRP62  LRP52  LRP22  LRP1B2  LDLR2  LRP5L2  LRP42  VLDLR2  
    NID12  NID22  LRP82  LRP12  
    8 SIMAP similar genes for EGF using alignment to 3 protein entries:     EGF_HUMAN (see all proteins):
    NRG2    EPGN    PAMR1    TGFA    LRP1B    AREG
    LRP5L    NRG4

    Find genes that share paralogs with EGF           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for EGF (see all 2324)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0394744
    Hypomagnesemia 4 (HOMG4)4--see VAR_0394742 P L mis40--------
    rs100172611,2
    C,F,A,H--106581114(+) gtgtgT/AgAAAC 3 -- int14Minor allele frequency- A:0.31NA WA EA 362
    rs1925674841,2
    --106657482(+) ACACAC/GACACA 3 -- int10--------
    rs1830770571,2
    --110626418(+) CACTGC/TAACCT 3 -- us2k10--------
    rs37562631,2
    C--110626541(-) TAACAC/TGGTGA 3 -- us2k10--------
    rs37562621,2
    C,F--110626583(-) AGGTGG/AGCAGA 3 -- us2k15Minor allele frequency- A:0.23WA NA EA 244
    rs1881635701,2
    --110626633(+) ACGCCA/CGGCTG 3 -- us2k10--------
    rs1910998611,2
    --110626643(+) GGAATA/GTAAAC 3 -- us2k10--------
    rs37562611,2
    C,F,H--110626665(-) GATTTA/GCAGAG 3 -- us2k123Minor allele frequency- G:0.18NS EA NA WA 2478
    rs1471020051,2
    C--110626735(+) ATTAGC/TTGCGA 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for EGF (110834040 - 110934118 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for EGF:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2672203CNV Deletion23128226
    esv2618042CNV Insertion19546169
    esv22936CNV Loss19812545
    nsv290769CNV Loss16902084
    nsv820232CNV Loss19587683

    Human Gene Mutation Database (HGMD): EGF
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing EGF
    DNA2.0 Custom Variant and Variant Library Synthesis for EGF

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 131530   
    OMIM disorders: 611718  
    UniProtKB/Swiss-Prot: EGF_HUMAN, P01133
  • Hypomagnesemia 4 (HOMG4) [MIM:611718]: A disorder characterized by massive renal hypomagnesemia and
    normal levels of serum calcium and calcium excretion. Clinical features include seizures, mild-to moderate
    psychomotor retardation, and brisk tendon reflexes. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • Selected diseases for EGF (see all 30):    
    About MalaCards
    renal hypomagnesemia 4    angiomatous meningioma    estrogen-receptor negative breast cancer    bronchiolo-alveolar adenocarcinoma
    breast cyst    embryonal cancer    congenital contractural arachnodactyly    microvillus inclusion disease
    sebaceous adenoma    cadasil    cerebral meningioma    anal fistula
    xanthogranulomatous pyelonephritis    choriocarcinoma    factor vii deficiency    thyroid cancer
    skin squamous cell carcinoma    zollinger-ellison syndrome    folliculitis    hepatocellular carcinoma, somatic


    Find genes that share disorders with EGF           About GenesLikeMe

    Selected Novoseek inferred disease relationships for EGF gene (see all 97)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 73.5 1513 2364377 (7), 2380332 (7), 1709063 (7), 2155590 (6) (see all 99)
    breast cancer 69.4 539 17940864 (6), 7749149 (4), 2032259 (4), 10554021 (4) (see all 99)
    carcinoma squamous cell 69.1 272 8137238 (3), 2346491 (3), 8638090 (3), 7529189 (3) (see all 99)
    cancer 64.3 494 7697894 (5), 2038286 (5), 1473218 (4), 16815674 (3) (see all 99)
    carcinoma 60.5 255 11288982 (3), 8321742 (3), 1528299 (3), 15958574 (3) (see all 99)
    glioma 58.9 211 10595738 (7), 19634110 (5), 17219981 (4), 12825816 (4) (see all 94)
    breast cysts 58.3 33 2249889 (3), 2141515 (3), 12779078 (2), 8368433 (2) (see all 17)
    pancreatic cancer 57.6 110 10360220 (7), 16340751 (4), 10050105 (4), 9816541 (4) (see all 57)
    glioblastoma 56.7 56 19148517 (3), 17575160 (2), 9440140 (2), 7714611 (2) (see all 33)
    prostate cancer 55.9 226 18511414 (4), 9892211 (4), 19356736 (4), 2330326 (3) (see all 99)

    Genetic Association Database (GAD): EGF
    Human Genome Epidemiology (HuGE) Navigator: EGF (130 documents)
    Tumor Gene Database (TGDB): EGF

    Export disorders for EGF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EGF gene, integrated from 10 sources (see all 5641):
    (articles sorted by number of sources associating them with EGF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Epidermal growth factor gene functional polymorphism and the risk of hepatocellular carcinoma in patients with cirrhosis. (PubMed id 18167406)1, 4, 9 Tanabe K.K....Fuchs B.C. (JAMA 2008)
    2. EGF promoter SNPs, plasma EGF levels and risk of breast cancer in Chinese women. (PubMed id 17940864)1, 4, 9 Wang Y....Shen H. (Breast Cancer Res. Treat. 2008)
    3. A functional epidermal growth factor (EGF) polymorphism, EGF serum levels, and esophageal adenocarcinoma risk and outcome. (PubMed id 18483390)1, 4, 9 Lanuti M....Christiani D.C. (Clin. Cancer Res. 2008)
    4. No association between EGF +61 A/G polymorphism and increased risk of glioma. (PubMed id 19634110)1, 4, 9 Liu X....Lu F. (Int. J. Biol. Markers 2009)
    5. No association between epidermal growth factor and epidermal growth factor receptor polymorphisms and nasopharyngeal carcinoma. (PubMed id 18722874)1, 4, 9 Gao L.B....Zhang L. (Cancer Genet. Cytogenet. 2008)
    6. No association between EGF gene polymorphism and gastric cancer. (PubMed id 16214932)1, 4, 9 Goto Y....Hamajima N. (amp 2005)
    7. Genetic variations in angiogenesis pathway genes predict tumor recurrence in localized adenocarcinoma of the esophagus. (PubMed id 20101173)1, 4, 9 Lurje G....Lenz H.J. (Ann. Surg. 2010)
    8. Epidermal growth factor genetic variation, breast cancer risk, and waiting time to onset of disease. (PubMed id 19388850)1, 4, 9 AraA_jo A.P....Medeiros R. (DNA Cell Biol. 2009)
    9. ESR1 and EGF genetic variation in relation to breast cancer risk and survival. (PubMed id 18271972)1, 4, 9 EinarsdA^ttir K....Liu J. (Breast Cancer Res. 2008)
    10. +61A&gt;G polymorphism in the EGF gene does not increase the risk of lung cancer. (PubMed id 17986122)1, 4, 9 Kang H.G....Park J.Y. (Respirology 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1950 HGNC: 3229 AceView: EGF Ensembl:ENSG00000138798 euGenes: HUgn1950
    ECgene: EGF Kegg: 1950 H-InvDB: EGF

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for EGF Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EGF Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/egf/
    Wikipedia http://en.wikipedia.org/wiki/Epidermal_growth_factor

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for EGF gene:
    Search GeneIP for patents involving EGF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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