Aliases for EFTUD1 Gene
External Ids for EFTUD1 Gene
Previous GeneCards Identifiers for EFTUD1 Gene
GeneCards Summary for EFTUD1 Gene
EFTUD1 (Elongation Factor Tu GTP Binding Domain Containing 1) is a Protein Coding gene. Diseases associated with EFTUD1 include shwachman-diamond syndrome. Among its related pathways are Ribosome biogenesis in eukaryotes. GO annotations related to this gene include GTP binding and ribosome binding.
UniProtKB/Swiss-Prot for EFTUD1 Gene
Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Has low intrinsic GTPase activity. GTPase activity is increased by contact with 60S ribosome subunits.