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EFS Gene

protein-coding   GIFtS: 55
GCID: GC14M023825

Embryonal Fyn-Associated Substrate

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Embryonal Fyn-Associated Substrate1 2     EFS22
Cas Scaffolding Protein Family Member 31 2 3     HEFS2
CASS32 3     SIN2
CAS32     Signal Transduction Protein (SH3 Containing)2
EFS12     hEFS3

External Ids:    HGNC: 168981   Entrez Gene: 102782   Ensembl: ENSG000001008427   OMIM: 6099065   UniProtKB: O432813   

Export aliases for EFS gene to outside databases

Previous GC identifers: GC14M017612 GC14M021815 GC14M022895 GC14M003942


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for EFS Gene:
The longest protein isoform encoded by this gene contains an SH3 domain, which is known to be important in
intracellular signal transduction. The protein encoded by a similiar gene in mice was shown to bind to SH3
domains of protein-tyrosine kinases. The function of this gene is unknown. Three alternatively spliced variants
encoding different isoforms have been described for this gene. (provided by RefSeq, Mar 2013)

GeneCards Summary for EFS Gene:
EFS (embryonal Fyn-associated substrate) is a protein-coding gene. Diseases associated with EFS include kidney cancer, and conduct disorder. GO annotations related to this gene include SH3 domain binding and protein domain specific binding. An important paralog of this gene is BCAR1.

UniProtKB/Swiss-Prot: EFS_HUMAN, O43281
Function: Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to
cell adhesion. May serve as an activator of SRC and a downstream effector. Interacts with the SH3 domain of FYN
and with CRK, SRC, and YES (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the EFS gene promoter:
         GR   p53   GR-beta   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEFS promoter sequence
   Search Chromatin IP Primers for EFS

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EFS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2-q12   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.2-q12

EFS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EFS gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M023825:  view genomic region     (about GC identifiers)

Start:
23,825,611 bp from pter      End:
23,834,961 bp from pter
Size:
9,351 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: EFS_HUMAN, O43281 (See protein sequence)
Recommended Name: Embryonal Fyn-associated substrate  
Size: 561 amino acids; 58815 Da
Secondary accessions: B2RAJ7 O43282
Alternative splicing: 2 isoforms:  O43281-1   O43281-2   

Explore the universe of human proteins at neXtProt for EFS: NX_O43281

Explore proteomics data for EFS at MOPED

Post-translational modifications: 

  • Phosphorylated on multiple tyrosine residues. Phosphorylated on tyrosines by FYN and SRC (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See EFS Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001264103.1  NP_005855.1  NP_115835.1  

    ENSEMBL proteins: 
     ENSP00000216733   ENSP00000340607   ENSP00000416684  

    EFS Human Recombinant Protein Products:

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    Novus Biologicals EFS Proteins
    Novus Biologicals EFS Lysates
    Browse Sino Biological Recombinant Proteins
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    Cloud-Clone Corp. Proteins for EFS

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    EFS Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for EFS
    Cloud-Clone Corp. CLIAs for EFS


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CASS: Cas scaffolding proteins

    2 InterPro protein domains:
     IPR021901 CAS_DUF3513
     IPR001452 SH3_domain

    Graphical View of Domain Structure for InterPro Entry O43281

    ProtoNet protein and cluster: O43281

    1 Blocks protein domain: IPB001452 SH3 domain signature

    UniProtKB/Swiss-Prot: EFS_HUMAN, O43281
    Domain: Contains a central domain (substrate domain) containing multiple potential SH2-binding sites and a
    C-terminal domain containing a divergent helix-loop-helix (HLH) motif. The SH2-binding sites putatively bind CRK,
    NCK and ABL SH2 domains
    Domain: The SH3-binding sites that bind to the SRC SH3 domain are required for interaction with CRK and are
    implicated in promotion of serum response element (SRE) activation. The SH3 domain interacts with PTK2/FAK1
    Similarity: Belongs to the CAS family
    Similarity: Contains 1 SH3 domain


    EFS for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EFS_HUMAN, O43281
    Function: Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to
    cell adhesion. May serve as an activator of SRC and a downstream effector. Interacts with the SH3 domain of FYN
    and with CRK, SRC, and YES (By similarity)

         Genatlas biochemistry entry for EFS:
    mouse Efs,embryonal Fyn associated substrate,with two alternatively spliced forms (EFS1 and EFS2),widely
    expressed,involved in signal transduction

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0017124SH3 domain binding IEA--
    GO:0019904protein domain specific binding IPI11984006
         
    EFS for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for EFS:
     Increased gamma-H2AX phosphory 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Efs):
     digestive/alimentary  hematopoietic system  immune system  liver/biliary system  renal/urinary system 
     respiratory system 

    EFS for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Efstm1Kale for EFS

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EFS
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for EFS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EFS
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EFS

    miRNA
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    miRTarBase miRNAs that target EFS:
    hsa-mir-193b-3p (MIRT016538)

    Block miRNA regulation of human, mouse, rat EFS using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate EFS:
    hsa-miR-320a hsa-miR-550a hsa-miR-320b hsa-miR-525-5p hsa-miR-143 hsa-miR-320d hsa-miR-32* hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmidEFS 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for EFS
    Predesigned siRNA for gene silencing in human, mouse, rat EFS

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): EFS (NM_005864)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EFS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EFS

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for EFS 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EFS


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    chloroplast2
    nucleus2
    cytoskeleton1
    extracellular1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS9349509

    EFS for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for EFS
    Interactions:

        GeneGlobe Interaction Network for EFS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for EFS (O432812, 3 ENSP000002167334) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRAPPC6AO758652, 3, ENSP000000062754MINT-67460 I2D: score=5 STRING: ENSP00000006275
    ABL1P005192, 3, ENSP000003614234MINT-8110335 I2D: score=3 STRING: ENSP00000361423
    PIK3R1P279862, 3, ENSP000002743354MINT-8111931 I2D: score=3 STRING: ENSP00000274335
    PLCG1P191742, 3, ENSP000002440074MINT-8112507 I2D: score=3 STRING: ENSP00000244007
    SH2D3CQ8N5H72, 3, ENSP000003178174MINT-66753 I2D: score=5 STRING: ENSP00000317817
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0035556intracellular signal transduction TAS9349509

    EFS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EFS

    Selected Novoseek inferred chemical compound relationships for EFS gene (see all 22)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    geldanamycin 58.3 5 9925731 (1), 10090774 (1), 11763165 (1), 12471618 (1)
    tyrosine 49.3 18 8647432 (3), 10949198 (1), 8561895 (1), 9575347 (1) (see all 13)
    radicicol 47 1 9925731 (1)
    gefitinib 42.2 1 17975165 (1), 16724239 (1)
    phosphotyrosine 35 5 15251573 (1), 12370048 (1), 19549916 (1)
    phosphatidylinositol 27.6 2 1708917 (1), 16324768 (1)
    proline 23.6 3 8013457 (2), 11708783 (1)
    rapamycin 14 1 19148492 (1)
    gtp 10.2 1 12746840 (1)
    h2o2 9.92 1 7750801 (1)



    EFS for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for EFS gene (3 alternative transcripts): 
    NM_001277174.1  NM_005864.3  NM_032459.2  

    Unigene Cluster for EFS:

    Embryonal Fyn-associated substrate
    Hs.24587  [show with all ESTs]
    Unigene Representative Sequence: NM_005864
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000216733(uc001wjo.3 uc001wjp.3 uc010tnm.2) ENST00000351354
    ENST00000429593
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat EFS using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate EFS:
    hsa-miR-320a hsa-miR-550a hsa-miR-320b hsa-miR-525-5p hsa-miR-143 hsa-miR-320d hsa-miR-32* hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmidEFS 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat EFS
    Clone
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    OriGene clones in human, mouse for EFS (see all 12)
    OriGene ORF clones in mouse, rat for EFS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): EFS (NM_005864)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EFS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EFS
    Primer
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    OriGene qPCR primer pairs and template standards for EFS
    OriGene qSTAR qPCR primer pairs in human, mouse for EFS
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EFS
      QuantiTect SYBR Green Assays in human, mouse, rat EFS
      QuantiFast Probe-based Assays in human, mouse, rat EFS

    Additional mRNA sequence: 

    AB001466.1 AB001467.1 AK295933.1 AK314221.1 BC034246.1 BC046403.1 

    9 DOTS entries:

    DT.454953  DT.100785989  DT.120776098  DT.100785990  DT.100717170  DT.91981229  DT.97794705  DT.99947698 
    DT.91701866 

    Selected AceView cDNA sequences (see all 135):

    AB001467 BF527688 BX420662 BC034246 BE502180 AU118149 AW772504 NM_005864 
    AW264170 BU580690 BQ019870 BM922092 BM716641 AB001466 AW089068 BG056379 
    NM_032459 CR594928 BQ007510 BM450357 AW239156 BC046403 AU279771 BQ015381 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for EFS    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7
    SP1:                                                      
    SP2:              -                                       
    SP3:                                                      


    ECgene alternative splicing isoforms for EFS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EFS expression in normal human tissues (normalized intensities)      EFS embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACGCGCCAGG
    EFS Expression
    About this image


    EFS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
             Olfactory Bulb   
    EFS Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EFS Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.24587

    UniProtKB/Swiss-Prot: EFS_HUMAN, O43281
    Tissue specificity: The protein has been detected in lung and placenta

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    QuantiFast Probe-based Assays in human, mouse, rat EFS
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EFS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for EFS gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Efs1 , 5 embryonal Fyn-associated substrate1, 5 80.48(n)1
    79.82(a)1
      14 (27.99 cM)5
    136441  NM_010112.41  NP_034242.21 
     549165435 
    lizard
    (Anolis carolinensis)
    Reptilia EFS6
    embryonal Fyn-associated substrate
    56(a)
    1 ↔ 1
    GL343680.1(207465-219784)
    zebrafish
    (Danio rerio)
    Actinopterygii CR388231.36
    Uncharacterized protein
    20(a)
    1 ↔ 1
    7(25218317-25236038) ENSDARG00000088835
    fruit fly
    (Drosophila melanogaster)
    Insecta p130CAS6
    p130CAS
    15(a)
    1 → many
    3L(152884-174517)


    ENSEMBL Gene Tree for EFS (if available)
    TreeFam Gene Tree for EFS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for EFS gene
    BCAR12  NEDD92  CASS42  

    EFS for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for EFS (see all 275)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0359124
    A colorectal cancer sample4--see VAR_0359122 M I mis40--------
    rs1926160711,2
    --23825109(+) CATTCA/TTCTGC 3 -- ds50010--------
    rs1446612951,2
    --23825118(+) GCAACC/TGCGGA 3 -- ds50010--------
    rs1851200881,2
    --23825119(+) CAACCA/GCGGAT 3 -- ds50010--------
    rs1475796091,2
    C--23825135(+) AGAAA-/ATGGTTTGT
    CCAGAAGGATG
    ATGAG
    3 -- ds50010--------
    rs128858601,2
    C,F--23825195(+) GCCAAG/CTGAAA 3 -- ds50014Minor allele frequency- C:0.08NA 126
    rs1396449051,2
    --23825288(+) TGTGGA/TGCAAA 3 -- ds50010--------
    rs1904217641,2
    --23825348(+) CAAGGA/CCCTTA 3 -- ds50010--------
    rs1442722441,2
    --23825607(+) TGTCGA/TATCTA 3 -- ds50010--------
    rs1817298701,2
    --23825684(+) ATTCAC/TAATAT 3 -- ut310--------

    HapMap Linkage Disequilibrium report for EFS (23825611 - 23834961 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for EFS:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv901493CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing EFS
    DNA2.0 Custom Variant and Variant Library Synthesis for EFS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609906    OMIM disorders: --

    Selected diseases for EFS (see all 32):    About MalaCards
    kidney cancer    conduct disorder    gastric adenocarcinoma    gout
    leprosy    anaplastic large cell lymphoma    myotonic dystrophy    attention deficit hyperactivity disorder
    astrocytoma    crohn's disease    alzheimer's disease    multiple myeloma
    breast and colorectal cancer    myeloma    osteosarcoma    neuroblastoma
    prostate cancer    ischemia    hepatitis b    lung cancer

    3 diseases from the University of Copenhagen DISEASES database for EFS:
    Attention deficit hyperactivity disorder     Heart disease     Conduct disorder

    EFS for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for EFS gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 14 7 17406066 (1), 18224443 (1), 15313928 (1), 18516279 (1) (see all 7)
    cancer 13 4 15264241 (1), 15501963 (1), 12471618 (1), 17972520 (1)
    prostate cancer 11.7 2 19141652 (1), 19549916 (1)
    mimicry 9.48 1 11309274 (1)
    ovarian carcinoma 8.11 1 12365030 (1)
    shock 4.82 3 17466979 (1), 16827123 (1), 17157164 (1)
    nsclc 3.79 1 17975165 (1)
    mammary tumor 1.12 2 11215674 (1), 16724239 (1)
    astrocytoma 0 1 8760599 (1)
    necrosis 0 1 17406066 (1)

    Human Genome Epidemiology (HuGE) Navigator: EFS (48 documents)

    Export disorders for EFS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EFS gene, integrated from 10 sources (see all 173):
    (articles sorted by number of sources associating them with EFS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of an Efs isoform that lacks the SH3 domain and chromosomal mapping of human Efs. (PubMed id 9349509)1, 2, 3, 9 Ishino M.... Sasaki T. (Oncogene 1997)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Coordinate activation of c-Src by SH3- and SH2-binding sites on a novel p130Cas-related protein, Sin. (PubMed id 8647432)1, 9 Alexandropoulos K. and Baltimore D. (amp 1996)
    4. The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins. (PubMed id 11984006)1, 9 Tchernev V.T.... Kingsmore S.F. (Mol. Med. 2002)
    5. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PubMed id 23314748)1 Nathan J.A....Goldberg A.L. (EMBO J. 2013)
    6. EFS shows biallelic methylation in uveal melanoma with poor prognosis as well as tissue-specific methylation. (PubMed id 21871071)1 Neumann L.C....Zeschnigk M. (BMC Cancer 2011)
    7. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    8. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (Genes Immun. 2010)
    9. Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PubMed id 17474147)1 Wu C....Li S.S. (Proteomics 2007)
    10. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10278 HGNC: 16898 AceView: EFS Ensembl:ENSG00000100842 euGenes: HUgn10278
    ECgene: EFS H-InvDB: EFS

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for EFS Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EFS Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for EFS gene:
    Search GeneIP for patents involving EFS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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