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Aliases for EFS Gene

Aliases for EFS Gene

  • Embryonal Fyn-Associated Substrate 2 3
  • Cas Scaffolding Protein Family Member 3 2 3 4
  • CASS3 3 4
  • HEFS 3 4
  • Signal Transduction Protein (SH3 Containing) 3
  • CAS3 3
  • EFS1 3
  • EFS2 3
  • SIN 3

External Ids for EFS Gene

Previous GeneCards Identifiers for EFS Gene

  • GC14M017612
  • GC14M021815
  • GC14M022895
  • GC14M023825
  • GC14M003942

Summaries for EFS Gene

Entrez Gene Summary for EFS Gene

  • The longest protein isoform encoded by this gene contains an SH3 domain, which is known to be important in intracellular signal transduction. The protein encoded by a similiar gene in mice was shown to bind to SH3 domains of protein-tyrosine kinases. The function of this gene is unknown. Three alternatively spliced variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2013]

GeneCards Summary for EFS Gene

EFS (Embryonal Fyn-Associated Substrate) is a Protein Coding gene. GO annotations related to this gene include protein domain specific binding and SH3 domain binding. An important paralog of this gene is NEDD9.

UniProtKB/Swiss-Prot for EFS Gene

  • Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May serve as an activator of SRC and a downstream effector. Interacts with the SH3 domain of FYN and with CRK, SRC, and YES (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EFS Gene

Genomics for EFS Gene

Regulatory Elements for EFS Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for EFS Gene

23,356,400 bp from pter
23,365,752 bp from pter
9,353 bases
Minus strand

Genomic View for EFS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EFS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EFS Gene

Proteins for EFS Gene

  • Protein details for EFS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Embryonal Fyn-associated substrate
    Protein Accession:
    Secondary Accessions:
    • B2RAJ7
    • B4DJ56
    • E9PGU2
    • O43282

    Protein attributes for EFS Gene

    561 amino acids
    Molecular mass:
    58815 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for EFS Gene


neXtProt entry for EFS Gene

Proteomics data for EFS Gene at MOPED

Post-translational modifications for EFS Gene

  • Phosphorylated on multiple tyrosine residues. Phosphorylated on tyrosines by FYN and SRC (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EFS Gene

No data available for DME Specific Peptides for EFS Gene

Domains for EFS Gene

Gene Families for EFS Gene

  • CASS :Cas scaffolding proteins

Protein Domains for EFS Gene


Suggested Antigen Peptide Sequences for EFS Gene

Graphical View of Domain Structure for InterPro Entry



  • O43281
  • Contains a central domain (substrate domain) containing multiple potential SH2-binding sites and a C-terminal domain containing a divergent helix-loop-helix (HLH) motif. The SH2-binding sites putatively bind CRK, NCK and ABL SH2 domains
  • The SH3-binding sites that bind to the SRC SH3 domain are required for interaction with CRK and are implicated in promotion of serum response element (SRE) activation. The SH3 domain interacts with PTK2/FAK1
  • Contains 1 SH3 domain.
  • Belongs to the CAS family.
genes like me logo Genes that share domains with EFS: view

Function for EFS Gene

Molecular function for EFS Gene

GENATLAS Biochemistry: mouse Efs,embryonal Fyn associated substrate,with two alternatively spliced forms (EFS1 and EFS2),widely expressed,involved in signal transduction
UniProtKB/Swiss-Prot Function: Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May serve as an activator of SRC and a downstream effector. Interacts with the SH3 domain of FYN and with CRK, SRC, and YES (By similarity).

Gene Ontology (GO) - Molecular Function for EFS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0017124 SH3 domain binding IEA --
GO:0019904 protein domain specific binding IPI 11984006
genes like me logo Genes that share ontologies with EFS: view
genes like me logo Genes that share phenotypes with EFS: view

Animal Models for EFS Gene

MGI Knock Outs for EFS:

Animal Model Products

CRISPR Products

miRNA for EFS Gene

miRTarBase miRNAs that target EFS

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for EFS Gene

Localization for EFS Gene

Subcellular locations from

Jensen Localization Image for EFS Gene COMPARTMENTS Subcellular localization image for EFS gene
Compartment Confidence
cytosol 3
chloroplast 2
nucleus 2
cytoskeleton 1
extracellular 1

Gene Ontology (GO) - Cellular Components for EFS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 9349509
genes like me logo Genes that share ontologies with EFS: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for EFS Gene

Pathways for EFS Gene

SuperPathways for EFS Gene

No Data Available

Gene Ontology (GO) - Biological Process for EFS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0035556 intracellular signal transduction TAS 9349509
genes like me logo Genes that share ontologies with EFS: view

No data available for Pathways by source for EFS Gene

Compounds for EFS Gene

(22) Novoseek inferred chemical compound relationships for EFS Gene

Compound -log(P) Hits PubMed IDs
geldanamycin 58.3 4
tyrosine 49.3 15
radicicol 47 1
gefitinib 42.2 2
phosphotyrosine 35 3
genes like me logo Genes that share compounds with EFS: view

Transcripts for EFS Gene

Unigene Clusters for EFS Gene

Embryonal Fyn-associated substrate:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EFS

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EFS Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7
SP2: -

Relevant External Links for EFS Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EFS Gene

mRNA expression in normal human tissues for EFS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EFS Gene

SOURCE GeneReport for Unigene cluster for EFS Gene Hs.24587

mRNA Expression by UniProt/SwissProt for EFS Gene

Tissue specificity: The protein has been detected in lung and placenta
genes like me logo Genes that share expressions with EFS: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for EFS Gene

Orthologs for EFS Gene

This gene was present in the common ancestor of animals.

Orthologs for EFS Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia EFS 35
  • 99.29 (n)
  • 99.46 (a)
EFS 36
  • 99 (a)
(Bos Taurus)
Mammalia EFS 35
  • 86.87 (n)
  • 86.45 (a)
EFS 36
  • 86 (a)
(Canis familiaris)
Mammalia EFS 35
  • 87.52 (n)
  • 87.7 (a)
EFS 36
  • 88 (a)
(Mus musculus)
Mammalia Efs 35
  • 80.48 (n)
  • 79.82 (a)
Efs 16
Efs 36
  • 81 (a)
(Monodelphis domestica)
Mammalia EFS 36
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 20 (a)
(Rattus norvegicus)
Mammalia Efs 35
  • 81.07 (n)
  • 80.36 (a)
(Anolis carolinensis)
Reptilia EFS 36
  • 56 (a)
(Danio rerio)
Actinopterygii CR388231.3 36
  • 20 (a)
fruit fly
(Drosophila melanogaster)
Insecta p130CAS 36
  • 15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6681 36
  • 18 (a)
Species with no ortholog for EFS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EFS Gene

Gene Tree for EFS (if available)
Gene Tree for EFS (if available)

Paralogs for EFS Gene

Paralogs for EFS Gene

genes like me logo Genes that share paralogs with EFS: view

Variants for EFS Gene

Sequence variations from dbSNP and Humsavar for EFS Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs4671 -- 23,356,504(-) CATGA(C/T)GCGCC utr-variant-3-prime
rs178631 -- 23,366,316(+) TAAGA(A/G)AAAGg upstream-variant-2KB
rs178632 -- 23,366,865(+) AGTCT(G/T)GGCCT upstream-variant-2KB
rs1008233 -- 23,358,399(-) cattt(A/G)tcagg intron-variant
rs1983652 -- 23,361,277(+) AACAT(A/G)TGAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EFS Gene

Variant ID Type Subtype PubMed ID
nsv901493 CNV Loss 21882294

Relevant External Links for EFS Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EFS Gene

Disorders for EFS Gene

(3) University of Copenhagen DISEASES for EFS Gene

(16) Novoseek inferred disease relationships for EFS Gene

Disease -log(P) Hits PubMed IDs
tumors 14 7
cancer 13 4
prostate cancer 11.7 2
mimicry 9.48 1
ovarian carcinoma 8.11 1

Relevant External Links for EFS

Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with EFS: view

No data available for UniProtKB/Swiss-Prot for EFS Gene

Publications for EFS Gene

  1. Identification of an Efs isoform that lacks the SH3 domain and chromosomal mapping of human Efs. (PMID: 9349509) Ishino M. … Sasaki T. (Oncogene 1997) 2 3 4 23
  2. Coordinate activation of c-Src by SH3- and SH2-binding sites on a novel p130Cas-related protein, Sin. (PMID: 8647432) Alexandropoulos K. … Baltimore D. (Genes Dev. 1996) 3 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins. (PMID: 11984006) Tchernev V.T. … Kingsmore S.F. (Mol. Med. 2002) 3 23
  5. Trafficking of L-type calcium channels mediated by the postsynaptic scaffolding protein AKAP79. (PMID: 12114507) Altier C. … Bourinet E. (J. Biol. Chem. 2002) 23

Products for EFS Gene

Sources for EFS Gene

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