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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EFS Gene

protein-coding   GIFtS: 53
GCID: GC14M023825

embryonal Fyn-associated substrate
 Explore 35 diseases affiliated with
EFS via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for EFS    

Aliases
for EFS gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Embryonal Fyn-Associated Substrate1 2     SIN1 2
CASS31 2 3     Cas Scaffolding Protein Family Member 32 3
EFS11 2     CAS32
EFS21 2     Signal Transduction Protein (SH3 Containing)2
HEFS1 2     HEFS1 2

External Ids:    HGNC: 168981   Entrez Gene: 102782   Ensembl: ENSG000001008427   OMIM: 6099065   UniProtKB: O432813   

Export aliases for EFS gene to outside databases

Previous GC identifers: GC14M017612 GC14M021815 GC14M022895 GC14M003942


Summaries
for EFS gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for EFS:
The protein encoded by this gene contains a SH3 domain, which is known to be important in intracellular signal
transduction. The protein encoded by a similiar gene in mice was shown to be able to bind to SH3 domain of
protein-tyrosine kinases. The function of this gene is unknown. Two alternatively spliced variants have been
described. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: EFS_HUMAN, O43281
Function: Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell
adhesion. May serve as an activator of SRC and a downstream effector. Interacts with the SH3 domain of FYN and with
CRK, SRC, and YES (By similarity)




Genomic Views
for EFS gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EFS gene promoter:
         GR   p53   GR-beta   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: EFS promoter sequence
   Search SABiosciences Chromatin IP Primers for EFS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EFS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2-q12   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.2-q12

EFS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EFS gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M023825:  view genomic region     (about GC identifiers)

Start:
 23,825,611 bp from pter      End:
 23,834,961 bp from pter
Size:
 9,351 bases      Orientation:
 minus strand

Proteins
for EFS gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: EFS_HUMAN, O43281 (See protein sequence)
Recommended Name: Embryonal Fyn-associated substrate  
Size: 561 amino acids; 58815 Da
Secondary accessions: B2RAJ7 O43282
Alternative splicing: 2 isoforms:  O43281-1   O43281-2   

Explore the universe of human proteins at neXtProt for EFS: NX_O43281

Post-translational modifications:

  • Phosphorylated on multiple tyrosine residues. Phosphorylated on tyrosines by FYN and SRC (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O43281

    • EFS Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_005855.1  NP_115835.1  

    ENSEMBL proteins: 
     ENSP00000216733   ENSP00000340607   ENSP00000416684  

    Human Recombinant Protein Products: 
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    Novus Biologicals EFS Proteins
    Novus Biologicals EFS Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for EFS

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS9349509


    EFS for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for EFS

    Protein Domains /
    Families
    for EFS gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    EFS for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR021901 CAS_DUF3513
     IPR001452 SH3_domain

    Graphical View of Domain Structure for InterPro Entry O43281

    ProtoNet protein and cluster: O43281

    1 Blocks protein family: IPB001452 SH3 domain signature

    UniProtKB/Swiss-Prot: EFS_HUMAN, O43281
    Domain: Contains a central domain (substrate domain) containing multiple potential SH2-binding sites and a C-terminal
    domain containing a divergent helix-loop-helix (HLH) motif. The SH2-binding sites putatively bind CRK, NCK and ABL SH2
    domains
    Domain: The SH3-binding sites that bind to the SRC SH3 domain are required for interaction with CRK and are implicated
    in promotion of serum response element (SRE) activation. The SH3 domain interacts with PTK2/FAK1
    Similarity: Belongs to the CAS family
    Similarity: Contains 1 SH3 domain


    Function
    for EFS gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: EFS_HUMAN, O43281
    Function: Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell
    adhesion. May serve as an activator of SRC and a downstream effector. Interacts with the SH3 domain of FYN and with
    CRK, SRC, and YES (By similarity)

         Genatlas biochemistry entry for EFS:
    mouse Efs,embryonal Fyn associated substrate,with two alternatively spliced forms (EFS1 and EFS2),widely
    expressed,involved in signal transduction

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EFS
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate EFS:
    hsa-miR-320a hsa-miR-550a hsa-miR-320b hsa-miR-525-5p hsa-miR-143 hsa-miR-320d hsa-miR-32* hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmid: EFS 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EFS (see all 7)
    OriGene shRNA RFP: EFS
    OriGene siRNA: EFS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EFS

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for EFS

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EFS (see all 5)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EFS 

    Cell Line
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    Search LifeMap BioReagents cell lines for EFS

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0017124SH3 domain binding IEA--
    GO:0019904protein domain specific binding IPI11984006


    EFS for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for EFS:
     Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-out Efstm1Kale for EFS
         5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Efs):
     digestive/alimentary  immune system  liver/biliary system  renal/urinary system  respiratory system 

    EFS for phenotypes           About GeneDecksing


    Pathways & Interactions
    for EFS gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for EFS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/23 Interacting proteins for EFS (O432812, 3 ENSP000002167334) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRAPPC6AO758652, 3, ENSP000000062754MINT-67460 I2D: score=5 STRING: ENSP00000006275
    ABL1P005192, 3, ENSP000003614234MINT-8110335 I2D: score=3 STRING: ENSP00000361423
    PIK3R1P279862, 3, ENSP000002743354MINT-8111931 I2D: score=3 STRING: ENSP00000274335
    PLCG1P191742, 3, ENSP000002440074MINT-8112507 I2D: score=3 STRING: ENSP00000244007
    SH2D3CQ8N5H72, 3, ENSP000003178174MINT-66753 I2D: score=5 STRING: ENSP00000317817
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0035556intracellular signal transduction TAS9349509


    EFS for ontologies           About GeneDecksing



    Drugs & Compounds
    for EFS gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    EFS for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for EFS
    10/22 Novoseek chemical compound relationships for EFS gene (see all 22)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    geldanamycin 58.3 5 9925731 (1), 10090774 (1), 11763165 (1), 12471618 (1)
    tyrosine 49.3 18 8647432 (3), 10949198 (1), 8561895 (1), 9575347 (1) (see all 13)
    radicicol 47 1 9925731 (1)
    gefitinib 42.2 1 17975165 (1), 16724239 (1)
    phosphotyrosine 35 5 15251573 (1), 12370048 (1), 19549916 (1)
    phosphatidylinositol 27.6 2 1708917 (1), 16324768 (1)
    proline 23.6 3 8013457 (2), 11708783 (1)
    rapamycin 14 1 19148492 (1)
    gtp 10.2 1 12746840 (1)
    h2o2 9.92 1 7750801 (1)

    Search CenterWatch for drugs/clinical trials and news about EFS 

    Transcripts
    for EFS gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for EFS gene (2 alternative transcripts): 
    NM_005864.2  NM_032459.1  

    Unigene Cluster for EFS:

    Embryonal Fyn-associated substrate
    Hs.24587  [show with all ESTs]
    Unigene Representative Sequence: NM_005864
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000216733(uc001wjo.3 uc001wjp.3 uc010tnm.2) ENST00000351354
    ENST00000429593

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EFS
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate EFS:
    hsa-miR-320a hsa-miR-550a hsa-miR-320b hsa-miR-525-5p hsa-miR-143 hsa-miR-320d hsa-miR-32* hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmid: EFS 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EFS (see all 7)
    OriGene shRNA RFP: EFS
    OriGene siRNA: EFS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EFS
    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EFS 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EFS
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EFS

    Additional cDNA sequence: 

    AB001466.1 AB001467.1 AK295933.1 AK314221.1 BC034246.1 BC046403.1 

    9 DOTS entries:

    DT.454953  DT.100785989  DT.120776098  DT.100785990  DT.100717170  DT.91981229  DT.97794705  DT.99947698 
    DT.91701866 

    24/135 AceView cDNA sequences (see all 135):

    BG056379 BQ015381 BC046403 BQ019870 CR594928 CD724057 BF527688 AB001466 
    AA460282 N63115 BC034246 AU118149 BX420662 NM_032459 BM450357 BM922092 
    AW239156 BE502180 BU580690 AW264170 AU279771 AW772504 AB001467 AW089068 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for EFS    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7
    SP1:                                                      
    SP2:              -                                       
    SP3:                                                      


    ECgene alternative splicing isoforms for EFS

    Expression
    for EFS gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EFS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACGCGCCAGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    EFS expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor EN7 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See EFS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EFS

    SOURCE GeneReport for Unigene cluster: Hs.24587

    UniProtKB/Swiss-Prot: EFS_HUMAN, O43281
    Tissue specificity: The protein has been detected in lung and placenta

        SABiosciences Custom PCR Arrays for EFS
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EFS

    Orthologs
    for EFS gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for EFS gene from 3/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia EFS6
    		 --
    		 55(a)
    		 1 ↔ 1
    		 GL343680.1(208238-217968)
    zebrafish
    (Danio rerio)    		 Actinopterygii CR388231.36
    		 --
    		 19(a)
    		 1 ↔ 1
    		 7(25218317-25236038)
    fruit fly
    (Drosophila melanogaster)    		 Insecta p130CAS6
    		 p130CAS
    		 14(a)
    		 1 → many
    		 3L(152884-174517)


    ENSEMBL Gene Tree for EFS (if available)
    TreeFam Gene Tree for EFS (if available) 

    Paralogs
    for EFS gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for EFS gene
    BCAR12  NEDD92  CASS42  

    EFS for paralogs           About GeneDecksing



    Genomic Variants
    for EFS gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/208 NCBI SNPs in EFS are shown (see all 208)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 14 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1446612951,2
    		--23825118(+) GCAACC/TGCGGA 2 -- ds50010--------
    rs1851200881,2
    		--23825119(+) CAACCA/GCGGAT 2 -- ds50010--------
    rs1475796091,2
    		C,--23825135(+) AGAAA-/ATGGTTTGT
    CCAGAAGGATG    ATGAG     		2 -- ds50010--------
    rs128858601,2
    		C,F,--23825195(+) GCCAAG/CTGAAA 2 -- ds50014Minor allele frequency- C:0.08NA 126
    rs1396449051,2
    		--23825288(+) TGTGGA/TGCAAA 2 -- ds50010--------
    rs1904217641,2
    		--23825348(+) CAAGGA/CCCTTA 2 -- ds50010--------
    rs1442722441,2
    		--23825607(+) TGTCGA/TATCTA 2 -- ds50010--------
    rs1817298701,2
    		--23825684(+) ATTCAC/TAATAT 2 -- ut310--------
    rs46711,2
    		C,F,O,A,H,--23825713(-) CATGAC/TGCGCC 1 -- ut31 ese333Minor allele frequency- T:0.45MN EA NA NS WA CSA 3945
    rs1847156471,2
    		--23825928(+) TCTCCA/GCCTTC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for EFS (23825611 - 23834961 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for EFS: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EFS
    DNA2.0 Custom Variant and Variant Library Synthesis for EFS

    Disorders / Diseases
    for EFS gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    EFS for disorders           About GeneDecksing

    OMIM gene information: 609906    OMIM disorders: --

    20/35 diseases for EFS (see all 35):    About MalaCards
    non-small cell lung carcinoma    anaplastic large cell lymphoma    chronic obstructive pulmonary disease    estrogen resistance
    myotonic dystrophy    conduction disease    pulmonary disease    multiple myeloma
    alzheimer's disease    lung carcinoma    leprosy    crohn's disease
    gastric adenocarcinoma    astrocytoma    hepatitis b    gout
    prostate cancer    kidney cancer    myeloma    carcinoma

    3 diseases from the University of Copenhagen DISEASES database for EFS:
    Attention deficit hyperactivity disorder     Heart disease     Conduct disorder

    10/16 Novoseek disease relationships for EFS gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 14 7 17406066 (1), 18224443 (1), 15313928 (1), 18516279 (1) (see all 7)
    cancer 13 4 15264241 (1), 15501963 (1), 12471618 (1), 17972520 (1)
    prostate cancer 11.7 2 19141652 (1), 19549916 (1)
    mimicry 9.48 1 11309274 (1)
    ovarian carcinoma 8.11 1 12365030 (1)
    shock 4.82 3 17466979 (1), 16827123 (1), 17157164 (1)
    nsclc 3.79 1 17975165 (1)
    mammary tumor 1.12 2 11215674 (1), 16724239 (1)
    astrocytoma 0 1 8760599 (1)
    necrosis 0 1 17406066 (1)

    Human Genome Epidemiology (HuGE) Navigator: EFS (48 documents)

    Export disorders for EFS gene to outside databases

    Publications
    for EFS gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EFS gene, integrated from 9 sources (see all 172):
    (articles sorted by number of sources associating them with EFS)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of an Efs isoform that lacks the SH3 domain and chromosomal mapping of human Efs. (PubMed id 9349509)1, 2, 3, 9 Ishino M.... Sasaki T. (1997)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Coordinate activation of c-Src by SH3- and SH2-binding sites on a novel p130Cas-related protein, Sin. (PubMed id 8647432)1, 9 Alexandropoulos K. and Baltimore D. (1996)
    4. The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins. (PubMed id 11984006)1, 9 Tchernev V.T....Kingsmore S.F. (2002)
    5. EFS shows biallelic methylation in uveal melanoma with poor prognosis as well as tissue-specific methylation. (PubMed id 21871071)1 Neumann L.C....Zeschnigk M. (2011)
    6. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    7. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
    8. Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PubMed id 17474147)1 Wu C....Li S.S. (2007)
    9. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
    10. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)

    External Searches for EFS gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing EFS gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10278 HGNC: 16898 AceView: EFS Ensembl:ENSG00000100842 euGenes: HUgn10278
    ECgene: EFS H-InvDB: EFS

    Other Databases showing EFS gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing EFS gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for EFS Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EFS Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for EFS gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for EFS gene:
    Search GeneIP for patents involving EFS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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