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Aliases for EFR3B Gene

Aliases for EFR3B Gene

  • EFR3 Homolog B 2 3
  • KIAA0953 2 3 4
  • EFR3 Homolog B (S. Cerevisiae) 2

External Ids for EFR3B Gene

Previous HGNC Symbols for EFR3B Gene

  • KIAA0953

Previous GeneCards Identifiers for EFR3B Gene

  • GC02P025118
  • GC02P025264

Summaries for EFR3B Gene

GeneCards Summary for EFR3B Gene

EFR3B (EFR3 Homolog B) is a Protein Coding gene. GO annotations related to this gene include binding. An important paralog of this gene is EFR3A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EFR3B Gene

Genomics for EFR3B Gene

Regulatory Elements for EFR3B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for EFR3B Gene

Chromosome:
2
Start:
25,042,104 bp from pter
End:
25,159,137 bp from pter
Size:
117,034 bases
Orientation:
Plus strand

Genomic View for EFR3B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EFR3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EFR3B Gene

Proteins for EFR3B Gene

  • Protein details for EFR3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2G0-EFR3B_HUMAN
    Recommended name:
    Protein EFR3 homolog B
    Protein Accession:
    Q9Y2G0
    Secondary Accessions:
    • B7WPL8
    • Q86XU6

    Protein attributes for EFR3B Gene

    Size:
    817 amino acids
    Molecular mass:
    92487 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA76797.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for EFR3B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EFR3B Gene

Proteomics data for EFR3B Gene at MOPED

Post-translational modifications for EFR3B Gene

  • Ubiquitination at Lys 38
  • Modification sites at PhosphoSitePlus

Other Protein References for EFR3B Gene

No data available for DME Specific Peptides for EFR3B Gene

Domains & Families for EFR3B Gene

Protein Domains for EFR3B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for EFR3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y2G0

UniProtKB/Swiss-Prot:

EFR3B_HUMAN :
  • Belongs to the EFR3 family.
Family:
  • Belongs to the EFR3 family.
genes like me logo Genes that share domains with EFR3B: view

No data available for Gene Families for EFR3B Gene

Function for EFR3B Gene

Gene Ontology (GO) - Molecular Function for EFR3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
genes like me logo Genes that share ontologies with EFR3B: view
genes like me logo Genes that share phenotypes with EFR3B: view

Animal Model Products

miRNA for EFR3B Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EFR3B

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for EFR3B Gene

Localization for EFR3B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for EFR3B Gene

Pathways & Interactions for EFR3B Gene

SuperPathways for EFR3B Gene

No Data Available

Interacting Proteins for EFR3B Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000384081%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000336127%0d%0a9606.ENSP00000458238%0d%0a9606.ENSP00000316699%0d%0a
Selected Interacting proteins: ENSP00000384081 for EFR3B Gene via STRING

Gene Ontology (GO) - Biological Process for EFR3B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for EFR3B Gene

Drugs & Compounds for EFR3B Gene

No Compound Related Data Available

Transcripts for EFR3B Gene

mRNA/cDNA for EFR3B Gene

(4) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EFR3B Gene

EFR3 homolog B (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EFR3B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EFR3B Gene

No ASD Table

Relevant External Links for EFR3B Gene

GeneLoc Exon Structure for
EFR3B
ECgene alternative splicing isoforms for
EFR3B

Expression for EFR3B Gene

mRNA expression in normal human tissues for EFR3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EFR3B Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.5) and Brain - Nucleus accumbens (basal ganglia) (x4.2).

Protein differential expression in normal tissues from HIPED for EFR3B Gene

This gene is overexpressed in Frontal cortex (33.8) and Brain (30.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EFR3B Gene



SOURCE GeneReport for Unigene cluster for EFR3B Gene Hs.4892

genes like me logo Genes that share expression patterns with EFR3B: view

Protein tissue co-expression partners for EFR3B Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for EFR3B Gene

Orthologs for EFR3B Gene

This gene was present in the common ancestor of animals.

Orthologs for EFR3B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EFR3B 35
  • 91.55 (n)
  • 97.43 (a)
EFR3B 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EFR3B 35
  • 91.8 (n)
  • 98.16 (a)
EFR3B 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Efr3b 35
  • 90.04 (n)
  • 97.55 (a)
Efr3b 16
Efr3b 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EFR3B 35
  • 97.76 (n)
  • 97.18 (a)
EFR3B 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Efr3b 35
  • 90.06 (n)
  • 97.91 (a)
oppossum
(Monodelphis domestica)
Mammalia EFR3B 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 68 (a)
OneToMany
-- 36
  • 92 (a)
OneToMany
-- 36
  • 51 (a)
OneToMany
chicken
(Gallus gallus)
Aves EFR3B 35
  • 82.21 (n)
  • 89.6 (a)
EFR3B 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 96 (a)
OneToMany
-- 36
  • 83 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia efr3b 35
  • 78.12 (n)
  • 87.24 (a)
zebrafish
(Danio rerio)
Actinopterygii efr3bb 35
  • 74.55 (n)
  • 80.76 (a)
efr3ba 36
  • 75 (a)
OneToMany
efr3bb 36
  • 81 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012183 35
  • 53.13 (n)
  • 45.12 (a)
fruit fly
(Drosophila melanogaster)
Insecta stmA 35
  • 51.48 (n)
  • 42.21 (a)
stmA 36
  • 38 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C32D5.3 35
  • 50.03 (n)
  • 43.72 (a)
C32D5.3 36
  • 33 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToMany
Species with no ortholog for EFR3B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EFR3B Gene

ENSEMBL:
Gene Tree for EFR3B (if available)
TreeFam:
Gene Tree for EFR3B (if available)

Paralogs for EFR3B Gene

Paralogs for EFR3B Gene

(1) SIMAP similar genes for EFR3B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with EFR3B: view

Variants for EFR3B Gene

Sequence variations from dbSNP and Humsavar for EFR3B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs475299 -- 25,107,233(+) CCCCA(A/T)GACCA intron-variant
rs475868 -- 25,095,190(+) cagtc(A/G)gagga intron-variant
rs478222 -- 25,078,886(+) CTTCA(A/T)CATCT intron-variant
rs480319 -- 25,095,653(+) atcac(A/G)ccact intron-variant
rs482546 -- 25,082,187(+) TGTGC(C/T)GGAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EFR3B Gene

Variant ID Type Subtype PubMed ID
dgv57n68 CNV Loss 17160897
esv2666849 CNV Deletion 23128226
esv33372 CNV Loss 17666407
nsv2647 CNV Insertion 18451855
esv24844 CNV Gain 19812545
esv1006182 OTHER Inversion 20482838

Variation tolerance for EFR3B Gene

Gene Damage Index Score: 1.72; 32.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EFR3B Gene

HapMap Linkage Disequilibrium report
EFR3B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EFR3B Gene

Disorders for EFR3B Gene

Relevant External Links for EFR3B

Genetic Association Database (GAD)
EFR3B
Human Genome Epidemiology (HuGE) Navigator
EFR3B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EFR3B
genes like me logo Genes that share disorders with EFR3B: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EFR3B Gene

Publications for EFR3B Gene

  1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. EFR3s are palmitoylated plasma membrane proteins that control responsiveness to G-protein-coupled receptors. (PMID: 25380825) Bojjireddy N. … Balla T. (J. Cell. Sci. 2015) 67
  4. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. (PMID: 23563607) Berndt S.I. … Ingelsson E. (Nat. Genet. 2013) 67
  5. Genome-wide association study of body mass index in 23 000 individuals with and without asthma. (PMID: 23517042) MelAcn E. … Lasky-Su J. (Clin. Exp. Allergy 2013) 67

Products for EFR3B Gene

Sources for EFR3B Gene

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