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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EFNB3 Gene

protein-coding   GIFtS: 61
GCID: GC17P007608

Ephrin-B3


(Previous symbol: EPLG8)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ephrin-B31 2     EPH-Related Receptor Transmembrane Ligand ELK-L32 3
EPLG81 2 3 5     EFL62 5
LERK82 3 5     Ephrin B32
EPH-Related Receptor Tyrosine Kinase Ligand 82 3     LERK-83

External Ids:    HGNC: 32281   Entrez Gene: 19492   Ensembl: ENSG000001089477   OMIM: 6022975   UniProtKB: Q157683   

Export aliases for EFNB3 gene to outside databases

Previous GC identifers: GC17U990024 GC17P008348 GC17P007551 GC17P007809 GC17P007549 GC17P007501


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for EFNB3 Gene:
EFNB3, a member of the ephrin gene family, is important in brain development as well as in its maintenance.
Moreover, since levels of EFNB3 expression were particularly high in several forebrain subregions compared to
other brain subregions, it may play a pivotal role in forebrain function. The EPH and EPH-related receptors
comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating
developmental events, particularly in the nervous system. EPH Receptors typically have a single kinase domain and
an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and
receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence
relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a
glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph
family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain
sequences and their affinities for binding ephrin-A and ephrin-B ligands. (provided by RefSeq, Jul 2008)

GeneCards Summary for EFNB3 Gene: 
EFNB3 (ephrin-B3) is a protein-coding gene. Diseases associated with EFNB3 include neuroblastoma, and osteosarcoma, and among its related super-pathways are Cell adhesion Ephrins signaling and Ephrin-Eph Signaling. GO annotations related to this gene include transmembrane-ephrin receptor activity and ephrin receptor binding. An important paralog of this gene is EFNB1.

UniProtKB/Swiss-Prot: EFNB3_HUMAN, Q15768
Function: Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are
crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds
promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into
neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the
signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in
forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a
role in constraining the orientation of longitudinally projecting axons (By similarity)

Gene Wiki entry for EFNB3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EFNB3 gene promoter:
         E2F-3a   C/EBPbeta   E2F   E2F-1   Sp1   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEFNB3 promoter sequence
   Search SABiosciences Chromatin IP Primers for EFNB3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EFNB3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

EFNB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EFNB3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P007608:  view genomic region     (about GC identifiers)

Start:
7,608,520 bp from pter      End:
7,614,696 bp from pter
Size:
6,177 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: EFNB3_HUMAN, Q15768 (See protein sequence)
Recommended Name: Ephrin-B3 precursor  
Size: 340 amino acids; 35835 Da
Subunit: Interacts with GRIP1 and GRIP2. Binds to Nipah virus G protein
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: B2RBW2 D3DTQ6 O00680 Q8TBH7 Q92875

Explore the universe of human proteins at neXtProt for EFNB3: NX_Q15768

Explore proteomics data for EFNB3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15768

  • EFNB3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    EFNB3 Protein Expression
    REFSEQ proteins: NP_001397.1  
    ENSEMBL proteins: 
     ENSP00000226091  

    Human Recombinant Protein Products for EFNB3: 
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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane TAS9126477
    GO:0016020membrane ----

    EFNB3 for ontologies           About GeneDecksing



    EFNB3 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    EFN: Ephrins

    3 InterPro protein domains:
     IPR001799 Ephrin
     IPR008972 Cupredoxin
     IPR019765 Ephrin_CS

    Graphical View of Domain Structure for InterPro Entry Q15768

    ProtoNet protein and cluster: Q15768

    1 Blocks protein domain: IPB001799 Ephrin signature

    UniProtKB/Swiss-Prot: EFNB3_HUMAN, Q15768
    Similarity: Belongs to the ephrin family
    Similarity: Contains 1 ephrin RBD (ephrin receptor-binding) domain


    EFNB3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EFNB3_HUMAN, Q15768
    Function: Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are
    crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds
    promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into
    neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the
    signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in
    forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a
    role in constraining the orientation of longitudinally projecting axons (By similarity)

         Genatlas biochemistry entry for EFNB3:
    ephrin B-3,eph-related receptor tyrosine kinase,class B,ligand,involved in short-range contact-mediated axonal
    guidance,expressed in fetal brain,and in adult forebrain

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005005transmembrane-ephrin receptor activity TAS9126477
    GO:0046875ephrin receptor binding IDA8808709
         
    EFNB3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for EFNB3:
     Decreased viability of wild-ty  Increased S DNA content 

         4 MGI mutant phenotypes (inferred from 9 alleles(MGI details for Efnb3):
     behavior/neurological  cellular  nervous system  normal 

    EFNB3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for EFNB3: Efnb3tm1Henk Efnb3tm1Nwg Efnb3tm1.2Henk

       inGenious Targeting Laboratory - Custom generated mouse model solutions for EFNB3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for EFNB3

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    SwitchGear 3'UTR luciferase reporter plasmidEFNB3 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for EFNB3 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Cell adhesion Ephrins signaling
    Cell adhesion Ephrins signaling0.30
    EPHB forward signaling0.30
    2EphB-EphrinB Signaling
    Ephrin-Eph Signaling0.58
    EphB-EphrinB Signaling0.58
    3Cytoskeleton remodeling Reverse signaling by ephrin B
    Cytoskeleton remodeling Reverse signaling by ephrin B0.94
    4Tyrosine Kinases / Adaptors
    Tyrosine Kinases / Adaptors
    5Angiogenesis
    Angiogenesis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for EFNB3
        Cytoskeleton remodeling Reverse signaling by ephrin B
    Cell adhesion Ephrins signaling

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for EFNB3
        EphB-EphrinB Signaling
    Ephrin-Eph Signaling

    2 Cell Signaling Technology (CST) Pathways for EFNB3
        Angiogenesis
    Tyrosine Kinases / Adaptors

    2 GeneGo (Thomson Reuters) Pathways for EFNB3
        Cytoskeleton remodeling Reverse signaling by ephrin B
    Cell adhesion Ephrins signaling

    1 BioSystems Pathway for EFNB3
        EPHB forward signaling



    1         Kegg Pathway  (Kegg details for EFNB3):
        Axon guidance


    EFNB3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for EFNB3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/33 Interacting proteins for EFNB3 (Q157683 ENSP000002260914) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EPHB3P547533, ENSP000003321184I2D: score=2 STRING: ENSP00000332118
    PARD3Q8TEW03, ENSP000003639214I2D: score=1 STRING: ENSP00000363921
    EPHA4P547643, ENSP000002818214I2D: score=2 STRING: ENSP00000281821
    RHBDL2Q9NX523, ENSP000002892484I2D: score=2 STRING: ENSP00000289248
    GRIP1Q9Y3R03, ENSP000003810984I2D: score=1 STRING: ENSP00000381098
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007267cell-cell signaling TAS9126477
    GO:0007399nervous system development TAS9126477
    GO:0007411axon guidance ----
    GO:0007628adult walking behavior IEA--
    GO:0016198axon choice point recognition IEA--

    EFNB3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    EFNB3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for EFNB3

    1 Novoseek inferred chemical compound relationship for EFNB3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 34.2 5 15720813 (1), 9126477 (1), 16951161 (1)

    Search CenterWatch for drugs/clinical trials and news about EFNB3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for EFNB3 gene: 
    NM_001406.3  

    Unigene Cluster for EFNB3:

    Ephrin-B3
    Hs.26988  [show with all ESTs]
    Unigene Representative Sequence: NM_001406
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000226091(uc002gis.3)
    miRNA
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    Additional mRNA sequence: 

    AK027329.1 AK314841.1 BC022499.1 BC042944.2 U57001.1 

    6 DOTS entries:

    DT.100813533  DT.445474  DT.91680350  DT.100813537  DT.120949968  DT.120950010 

    24/67 AceView cDNA sequences (see all 67):

    AA973977 AA417565 BM974629 BU854800 NM_001406 BI913360 BU557245 BU859261 
    AI088793 BU554039 BG701666 AA932672 BG236774 BI488464 BM677430 AW303554 
    AA055762 BC022499 AA485665 BI488844 BX352973 BU685648 AI611843 BM545398 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EFNB3 expression in normal human tissues (normalized intensities)      EFNB3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGCGGGAT
    EFNB3 Expression
    About this image


    EFNB3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/14 selected tissues (see all 14) fully expand
     
     Brain (Nervous System)    fully expand to see all 15 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
             Thalamus
             Midbrain   
     
     Neural Tube (Nervous System)    fully expand to see all 7 entries
             Telencephalon
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Human Keratocyte (HK)   
             sensory organ/eye/optic chiasma   
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 2 entries
             PureStem 4D20.8, NCr-fac Progenitor
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   

    See EFNB3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EFNB3

    SOURCE GeneReport for Unigene cluster: Hs.26988

    UniProtKB/Swiss-Prot: EFNB3_HUMAN, Q15768
    Tissue specificity: Highly expressed in brain; expressed in embryonic floor plate, roof plate and hindbrain
    segments

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EFNB3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for EFNB3 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Efnb31 , 5 ephrin B31, 5 91.96(n)1
    95.59(a)1
      11 (42.80 cM)5
    136431  NM_007911.51  NP_031937.11 
     695540925 
    lizard
    (Anolis carolinensis)
    Reptilia EFNB36
    Uncharacterized protein
    52(a)
    1 ↔ 1
    GL343655.1(233302-325411)
    African clawed frog
    (Xenopus laevis)
    Amphibia efnb3-A2 ephrin-B3 78.98(n)    AJ236866.1 
    zebrafish
    (Danio rerio)
    Actinopterygii efnb32 ephrin B3 78.64(n)   114378  AF375227.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ephrin6
    Ephrin
    8(a)
    1 → many
    4(592381-600748)
    worm
    (Caenorhabditis elegans)
    Secernentea efn-26
    efn-36
    (see all 3)
    Protein EFN-3
    (see all 3)
    23(a)
    22(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    IV(10576350-10578286)
    X(13475910-13477456)


    ENSEMBL Gene Tree for EFNB3 (if available)
    TreeFam Gene Tree for EFNB3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for EFNB3 gene
    EFNB12  EFNB22  
    2 SIMAP similar genes for EFNB3 using alignment to 1 protein entry:     EFNB3_HUMAN:
    EFNB2    EFNB1

    EFNB3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/160 SNPs in EFNB3 are shown (see all 160)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0023564
    ----see VAR_0023562 R Q mis40--------
    rs1869998861,2
    --7607351(+) AAAGGC/TGTTGA 1 -- us2k10--------
    rs1922920831,2
    --7607447(+) TTTCTC/TCATTT 1 -- us2k10--------
    rs99123341,2
    C--7607475(+) GGGTGG/AGGGAC 1 -- us2k11Minor allele frequency- A:0.00NA 2
    rs1123988691,2
    F--7607492(+) GTCATC/TTGAAG 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1860349401,2
    --7607516(+) CTCCTC/TCCCCC 1 -- us2k10--------
    rs1476134451,2
    --7607526(+) CAACAA/CCTTCC 1 -- us2k10--------
    rs1420921481,2
    --7607600(+) CACAAC/TCAAAG 1 -- us2k10--------
    rs1458537091,2
    --7607629(+) GGGGAA/GGCTTG 1 -- us2k10--------
    rs773126921,2
    C--7607743(+) TTCCTG/TCGCAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for EFNB3 (7608520 - 7614696 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for EFNB3: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing EFNB3
    DNA2.0 Custom Variant and Variant Library Synthesis for EFNB3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602297    OMIM disorders: --

    6 diseases for EFNB3:    About MalaCards
    neuroblastoma    osteosarcoma    glioblastoma    ovarian cancer
    lung cancer    neuronitis


    EFNB3 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for EFNB3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    brain tumors 28.2 2 16596216 (1)
    glioma 23.2 4 16951161 (3), 15720813 (1)
    tumors 13.3 8 10984508 (1), 16596216 (1), 16951161 (1), 12695554 (1) (see all 5)

    Genetic Association Database (GAD): EFNB3
    Human Genome Epidemiology (HuGE) Navigator: EFNB3 (4 documents)

    Export disorders for EFNB3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EFNB3 gene, integrated from 9 sources (see all 48):
    (articles sorted by number of sources associating them with EFNB3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning, chromosomal localization, and expression pattern of EPLG8, a new member of the EPLG gene family encoding ligands of EPH- related protein-tyrosine kinase receptors. (PubMed id 9126477)1, 2, 3, 9 Tang X.X.... Ikegaki N. (1997)
    2. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (2010)
    3. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (2009)
    4. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1, 4 Hosgood H.D....Lan Q. (2008)
    5. Two key residues in ephrinB3 are critical for its use as an alternative receptor for Nipah virus. (PubMed id 16477309)1, 2 Negrete O.A.... Lee B. (2006)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains. (PubMed id 10197531)1, 2 Brueckner K....Klein R. (1999)
    10. Elk-L3, a novel transmembrane ligand for the Eph family of receptor tyrosine kinases, expressed in embryonic floor plate, roof plate and hindbrain segments. (PubMed id 8808709)1, 2 Gale N.W.... Yancopoulos G.D. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1949 HGNC: 3228 AceView: EFNB3 Ensembl:ENSG00000108947 euGenes: HUgn1949
    ECgene: EFNB3 Kegg: 1949 H-InvDB: EFNB3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for EFNB3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for EFNB3 gene:
    Search GeneIP for patents involving EFNB3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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