Free for academic non-profit institutions. Other users need a Commercial license

Aliases for EFNB3 Gene

Aliases for EFNB3 Gene

  • Ephrin-B3 2 3
  • EPLG8 3 4 6
  • LERK8 3 4 6
  • EPH-Related Receptor Transmembrane Ligand ELK-L3 3 4
  • EFL6 3 6
  • Eph-Related Receptor Tyrosine Kinase Ligand 8 3
  • EPH-Related Receptor Tyrosine Kinase Ligand 8 4
  • Ephrin B3 3
  • LERK-8 4

External Ids for EFNB3 Gene

Previous Symbols for EFNB3 Gene

  • EPLG8

Summaries for EFNB3 Gene

Entrez Gene Summary for EFNB3 Gene

  • EFNB3, a member of the ephrin gene family, is important in brain development as well as in its maintenance. Moreover, since levels of EFNB3 expression were particularly high in several forebrain subregions compared to other brain subregions, it may play a pivotal role in forebrain function. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH Receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. [provided by RefSeq, Jul 2008]

GeneCards Summary for EFNB3 Gene

EFNB3 (Ephrin-B3) is a Protein Coding gene. Diseases associated with EFNB3 include lung cancer. Among its related pathways are Tyrosine Kinases / Adaptors and Angiogenesis (CST). GO annotations related to this gene include ephrin receptor binding and transmembrane-ephrin receptor activity. An important paralog of this gene is EFNB2.

UniProtKB/Swiss-Prot for EFNB3 Gene

  • Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity).

Gene Wiki entry for EFNB3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EFNB3 Gene

Genomics for EFNB3 Gene

Genomic Location for EFNB3 Gene

Start:
7,705,202 bp from pter
End:
7,711,378 bp from pter
Size:
6,177 bases
Orientation:
Plus strand

Genomic View for EFNB3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EFNB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EFNB3 Gene

Regulatory Elements for EFNB3 Gene

Proteins for EFNB3 Gene

  • Protein details for EFNB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15768-EFNB3_HUMAN
    Recommended name:
    Ephrin-B3
    Protein Accession:
    Q15768
    Secondary Accessions:
    • B2RBW2
    • D3DTQ6
    • O00680
    • Q8TBH7
    • Q92875

    Protein attributes for EFNB3 Gene

    Size:
    340 amino acids
    Molecular mass:
    35835 Da
    Quaternary structure:
    • Interacts with GRIP1 and GRIP2. Binds to Nipah virus G protein.

    Three dimensional structures from OCA and Proteopedia for EFNB3 Gene

neXtProt entry for EFNB3 Gene

Proteomics data for EFNB3 Gene at MOPED

Post-translational modifications for EFNB3 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn210

Other Protein References for EFNB3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EFNB3 Gene

Domains for EFNB3 Gene

Gene Families for EFNB3 Gene

HGNC:

Protein Domains for EFNB3 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

EFNB3_HUMAN
Domain:
  • Contains 1 ephrin RBD (ephrin receptor-binding) domain.:
    • Q15768
Family:
  • Belongs to the ephrin family.:
    • Q15768
genes like me logo Genes that share domains with EFNB3: view

Function for EFNB3 Gene

Molecular function for EFNB3 Gene

GENATLAS Biochemistry: ephrin B-3,eph-related receptor tyrosine kinase,class B,ligand,involved in short-range contact-mediated axonal guidance,expressed in fetal brain,and in adult forebrain
UniProtKB/Swiss-Prot Function: Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity).

Gene Ontology (GO) - Molecular Function for EFNB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005005 transmembrane-ephrin receptor activity TAS 9126477
GO:0046875 ephrin receptor binding IDA 8808709
genes like me logo Genes that share ontologies with EFNB3: view
genes like me logo Genes that share phenotypes with EFNB3: view

Animal Models for EFNB3 Gene

MGI Knock Outs for EFNB3:

miRNA for EFNB3 Gene

miRTarBase miRNAs that target EFNB3

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for EFNB3 Gene

Localization for EFNB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EFNB3 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EFNB3 Gene COMPARTMENTS Subcellular localization image for EFNB3 gene
Compartment Confidence
plasma membrane 4
extracellular 2
cytoskeleton 1
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for EFNB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9126477
GO:0016020 membrane --
genes like me logo Genes that share ontologies with EFNB3: view

Pathways for EFNB3 Gene

genes like me logo Genes that share pathways with EFNB3: view

Pathways by source for EFNB3 Gene

2 GeneGo (Thomson Reuters Life Sciences Research) pathways for EFNB3 Gene
2 Qiagen pathways for EFNB3 Gene
2 Cell Signaling Technology pathways for EFNB3 Gene
1 BioSystems pathway for EFNB3 Gene
1 KEGG pathway for EFNB3 Gene

Gene Ontology (GO) - Biological Process for EFNB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007267 cell-cell signaling TAS 9126477
GO:0007399 nervous system development TAS 9126477
GO:0007411 axon guidance TAS --
GO:0007628 adult walking behavior IEA --
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with EFNB3: view

Compounds for EFNB3 Gene

(1) Novoseek inferred chemical compound relationships for EFNB3 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 34.2 3
genes like me logo Genes that share compounds with EFNB3: view

Transcripts for EFNB3 Gene

mRNA/cDNA for EFNB3 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(67) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EFNB3 Gene

Ephrin-B3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EFNB3 Gene

No ASD Table

Relevant External Links for EFNB3 Gene

GeneLoc Exon Structure for
EFNB3
ECgene alternative splicing isoforms for
EFNB3

Expression for EFNB3 Gene

mRNA expression in normal human tissues for EFNB3 Gene

mRNA differential expression in normal tissues according to GTEx for EFNB3 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (6.5), Brain - Anterior cingulate cortex (BA24) (5.3), Brain - Cortex (4.9), Brain - Hypothalamus (4.9), Brain - Frontal Cortex (BA9) (4.4), and Brain - Caudate (basal ganglia) (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for EFNB3 Gene

SOURCE GeneReport for Unigene cluster for EFNB3 Gene Hs.26988

mRNA Expression by UniProt/SwissProt for EFNB3 Gene

Q15768-EFNB3_HUMAN
Tissue specificity: Highly expressed in brain; expressed in embryonic floor plate, roof plate and hindbrain segments
genes like me logo Genes that share expressions with EFNB3: view

Orthologs for EFNB3 Gene

This gene was present in the common ancestor of animals.

Orthologs for EFNB3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EFNB3 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EFNB3 36
  • 94.71 (n)
  • 96.76 (a)
EFNB3 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EFNB3 36
  • 93.43 (n)
  • 96.72 (a)
EFNB3 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Efnb3 36
  • 91.96 (n)
  • 95.59 (a)
Efnb3 16
Efnb3 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EFNB3 37
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Efnb3 36
  • 93.43 (n)
  • 96.76 (a)
lizard
(Anolis carolinensis)
Reptilia EFNB3 37
  • 57 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia efnb3-A 36
tropical clawed frog
(Silurana tropicalis)
Amphibia efnb3 36
  • 62.64 (n)
  • 62.08 (a)
zebrafish
(Danio rerio)
Actinopterygii efnb3 36
efnb3a 37
  • 50 (a)
OneToMany
efnb3b 36
  • 60 (n)
  • 58.33 (a)
efnb3b 37
  • 53 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Ephrin 37
  • 10 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea efn-2 37
  • 26 (a)
ManyToMany
efn-3 37
  • 29 (a)
ManyToMany
vab-2 37
  • 24 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7000 37
  • 25 (a)
OneToMany
Species with no ortholog for EFNB3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EFNB3 Gene

ENSEMBL:
Gene Tree for EFNB3 (if available)
TreeFam:
Gene Tree for EFNB3 (if available)

Paralogs for EFNB3 Gene

Paralogs for EFNB3 Gene

Selected SIMAP similar genes for EFNB3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with EFNB3: view

Variants for EFNB3 Gene

Sequence variations from dbSNP and Humsavar for EFNB3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs7141 -- 7,711,283(+) GCGGG(A/G)TATGC utr-variant-3-prime
rs2229847 -- 7,709,386(+) CCTGG(A/G)GGGTG missense, reference
rs2287496 -- 7,708,766(+) CCTGC(C/T)TTCCC intron-variant
rs3744262 -- 7,710,447(-) CTGTC(C/T)GGGCC utr-variant-3-prime
rs3744263 -- 7,710,390(-) CATTC(A/G)GCATC utr-variant-3-prime

Relevant External Links for EFNB3 Gene

HapMap Linkage Disequilibrium report
EFNB3

No data available for Structural Variations from Database of Genomic Variants (DGV) for EFNB3 Gene

Disorders for EFNB3 Gene

(1) MalaCards Diseases for EFNB3 Gene

Search for EFNB3 Gene in MalaCards »

(3) Novoseek inferred disease relationships for EFNB3 Gene

Disease -log(P) Hits PubMed IDs
brain tumors 28.2 1
glioma 23.2 4
tumors 13.3 5

Relevant External Links for EFNB3

Genetic Association Database (GAD)
EFNB3
Human Genome Epidemiology (HuGE) Navigator
EFNB3
genes like me logo Genes that share disorders with EFNB3: view

No data available for UniProtKB/Swiss-Prot for EFNB3 Gene

Publications for EFNB3 Gene

  1. cDNA cloning, chromosomal localization, and expression pattern of EPLG8, a new member of the EPLG gene family encoding ligands of EPH- related protein-tyrosine kinase receptors. (PMID: 9126477) Tang X.X. … Ikegaki N. (Genomics 1997) 2 3 4 23
  2. Ephrin-B3 ligand promotes glioma invasion through activation of Rac1. (PMID: 16951161) Nakada M. … Berens M.E. (Cancer Res. 2006) 3 23
  3. EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains. (PMID: 10197531) Brueckner K. … Klein R. (Neuron 1999) 3 4
  4. Elk-L3, a novel transmembrane ligand for the Eph family of receptor tyrosine kinases, expressed in embryonic floor plate, roof plate and hindbrain segments. (PMID: 8808709) Gale N.W. … Yancopoulos G.D. (Oncogene 1996) 3 4
  5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4

Products for EFNB3 Gene

Sources for EFNB3 Gene

Back to Top

Content