Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



EFNB3 Gene

protein-coding   GIFtS: 62
GCID: GC17P007608

Ephrin-B3


(Previous symbol: EPLG8)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
ephrin-B31 2     EPH-Related Receptor Transmembrane Ligand ELK-L32 3
EPLG81 2 3 5     EFL62 5
LERK82 3 5     Ephrin B32
EPH-Related Receptor Tyrosine Kinase Ligand 82 3     LERK-83

External Ids:    HGNC: 32281   Entrez Gene: 19492   Ensembl: ENSG000001089477   OMIM: 6022975   UniProtKB: Q157683   

Export aliases for EFNB3 gene to outside databases

Previous GC identifers: GC17U990024 GC17P008348 GC17P007551 GC17P007809 GC17P007549 GC17P007501


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for EFNB3 Gene:
EFNB3, a member of the ephrin gene family, is important in brain development as well as in its maintenance.
Moreover, since levels of EFNB3 expression were particularly high in several forebrain subregions compared to
other brain subregions, it may play a pivotal role in forebrain function. The EPH and EPH-related receptors
comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating
developmental events, particularly in the nervous system. EPH Receptors typically have a single kinase domain and
an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and
receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence
relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a
glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph
family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain
sequences and their affinities for binding ephrin-A and ephrin-B ligands. (provided by RefSeq, Jul 2008)

GeneCards Summary for EFNB3 Gene:
EFNB3 (ephrin-B3) is a protein-coding gene. Diseases associated with EFNB3 include lung cancer susceptibility, and glioblastoma multiforme. GO annotations related to this gene include transmembrane-ephrin receptor activity and ephrin receptor binding. An important paralog of this gene is EFNB1.

UniProtKB/Swiss-Prot: EFNB3_HUMAN, Q15768
Function: Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are
crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds
promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into
neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the
signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in
forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a
role in constraining the orientation of longitudinally projecting axons (By similarity)

Gene Wiki entry for EFNB3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010718.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the EFNB3 gene promoter:
         E2F-3a   C/EBPbeta   E2F   E2F-1   Sp1   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEFNB3 promoter sequence
   Search Chromatin IP Primers for EFNB3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EFNB3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

EFNB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EFNB3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P007608:  view genomic region     (about GC identifiers)

Start:
7,608,520 bp from pter      End:
7,614,696 bp from pter
Size:
6,177 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: EFNB3_HUMAN, Q15768 (See protein sequence)
Recommended Name: Ephrin-B3 precursor  
Size: 340 amino acids; 35835 Da
Subunit: Interacts with GRIP1 and GRIP2. Binds to Nipah virus G protein
1 PDB 3D structure from and Proteopedia for EFNB3:
4BKF (3D)    
Secondary accessions: B2RBW2 D3DTQ6 O00680 Q8TBH7 Q92875

Explore the universe of human proteins at neXtProt for EFNB3: NX_Q15768

Explore proteomics data for EFNB3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn210
  • Modification sites at PhosphoSitePlus

  • See EFNB3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001397.1  
    ENSEMBL proteins: 
     ENSP00000226091  

    EFNB3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for EFNB3 (Ephrin-B3)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for EFNB3
    GenScript Custom Purified and Recombinant Proteins Services for EFNB3
    Novus Biologicals EFNB3 Protein
    Sino Biological Recombinant Protein for EFNB3
    Sino Biological Cell Lysate for EFNB3
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for EFNB3

    EFNB3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for EFNB3 (Ephrin-B3)
    Cell Signaling Technology (CST) Antibodies for EFNB3 
    OriGene Antibodies for EFNB3
    OriGene Custom Antibody Services for EFNB3
    Novus Biologicals EFNB3 Antibodies
    Abcam antibodies for EFNB3
    Cloud-Clone Corp. Antibodies for EFNB3
    ThermoFisher Antibodies for EFNB3
    LSBio Antibodies in human, mouse, rat for EFNB3

    EFNB3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for EFNB3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for EFNB3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for EFNB3
    Cloud-Clone Corp. CLIAs for EFNB3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    EFN: Ephrins

    3 InterPro protein domains:
     IPR001799 Ephrin
     IPR008972 Cupredoxin
     IPR019765 Ephrin_CS

    Graphical View of Domain Structure for InterPro Entry Q15768

    ProtoNet protein and cluster: Q15768

    1 Blocks protein domain: IPB001799 Ephrin signature

    UniProtKB/Swiss-Prot: EFNB3_HUMAN, Q15768
    Similarity: Belongs to the ephrin family
    Similarity: Contains 1 ephrin RBD (ephrin receptor-binding) domain


    EFNB3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EFNB3_HUMAN, Q15768
    Function: Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are
    crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds
    promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into
    neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the
    signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in
    forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a
    role in constraining the orientation of longitudinally projecting axons (By similarity)

         Genatlas biochemistry entry for EFNB3:
    ephrin B-3,eph-related receptor tyrosine kinase,class B,ligand,involved in short-range contact-mediated axonal
    guidance,expressed in fetal brain,and in adult forebrain

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005005transmembrane-ephrin receptor activity TAS9126477
    GO:0046875ephrin receptor binding IDA8808709
         
    EFNB3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for EFNB3:
     Decreased viability of wild-ty  Increased S DNA content 

         4 MGI mutant phenotypes (inferred from 9 alleles(MGI details for Efnb3):
     behavior/neurological  cellular  nervous system  normal 

    EFNB3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for EFNB3: Efnb3tm1Henk Efnb3tm1Nwg Efnb3tm1.2Henk

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EFNB3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for EFNB3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EFNB3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EFNB3

    miRNA
    Products:
        
    miRTarBase miRNAs that target EFNB3:
    hsa-mir-484 (MIRT042247)

    Block miRNA regulation of human, mouse, rat EFNB3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EFNB3 (see all 60):
    hsa-miR-607 hsa-miR-520e hsa-miR-302d hsa-miR-765 hsa-miR-3138 hsa-miR-3653 hsa-miR-371-5p hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidEFNB3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for EFNB3
    Predesigned siRNA for gene silencing in human, mouse, rat EFNB3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for EFNB3

    Clone
    Products:
         
    OriGene clones in human, mouse for EFNB3 (see all 7)
    OriGene ORF clones in mouse, rat for EFNB3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: EFNB3 (NM_001406)
    Sino Biological Human cDNA Clone for EFNB3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EFNB3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EFNB3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for EFNB3
    Browse ESI BIO Cell Lines and PureStem Progenitors for EFNB3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EFNB3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    EFNB3_HUMAN, Q15768: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    extracellular2
    cytoskeleton1
    endoplasmic reticulum1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IBA--
    GO:0005887integral component of plasma membrane TAS9126477
    GO:0016020membrane ----

    EFNB3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for EFNB3 About    
    See pathways by source

    SuperPathContained pathways About
    1EphB-EphrinB Signaling
    EphB-EphrinB Signaling0.58
    Cytoskeleton remodeling Reverse signaling by ephrin B0.34
    Ephrin-Eph Signaling0.58
    2EPHB forward signaling
    EPHB forward signaling0.30
    Cell adhesion Ephrins signaling0.30
    3Tyrosine Kinases / Adaptors
    Tyrosine Kinases / Adaptors
    4Axon guidance
    Axon guidance
    5Angiogenesis (CST)
    Angiogenesis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for EFNB3
        EphB-EphrinB Signaling
    Ephrin-Eph Signaling

    2 Cell Signaling Technology (CST) Pathways for EFNB3
        Angiogenesis
    Tyrosine Kinases / Adaptors

    2 GeneGo (Thomson Reuters) Pathways for EFNB3
        Cytoskeleton remodeling Reverse signaling by ephrin B
    Cell adhesion Ephrins signaling

    1 BioSystems Pathway for EFNB3
        EPHB forward signaling



    1 Kegg Pathway  (Kegg details for EFNB3):
        Axon guidance


    EFNB3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for EFNB3
    Interactions:

        GeneGlobe Interaction Network for EFNB3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for EFNB3 (Q157683 ENSP000002260914) via UniProtKB, MINT, STRING, and/or I2D (see all 43)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EPHB3P547533, ENSP000003321184I2D: score=2 STRING: ENSP00000332118
    PARD3Q8TEW03, ENSP000003639214I2D: score=1 STRING: ENSP00000363921
    SDCBPO005603, ENSP000002601304I2D: score=1 STRING: ENSP00000260130
    EPHA4P547643, ENSP000002818214I2D: score=2 STRING: ENSP00000281821
    RHBDL2Q9NX523, ENSP000002892484I2D: score=2 STRING: ENSP00000289248
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007267cell-cell signaling TAS9126477
    GO:0007399nervous system development TAS9126477
    GO:0007411axon guidance IBA--
    GO:0007628adult walking behavior IEA--
    GO:0016032viral process IEA--

    EFNB3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EFNB3

    1 Novoseek inferred chemical compound relationship for EFNB3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 34.2 5 15720813 (1), 9126477 (1), 16951161 (1)



    EFNB3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for EFNB3 gene: 
    NM_001406.3  

    Unigene Cluster for EFNB3:

    Ephrin-B3
    Hs.26988  [show with all ESTs]
    Unigene Representative Sequence: NM_001406
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000226091(uc002gis.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat EFNB3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EFNB3 (see all 60):
    hsa-miR-607 hsa-miR-520e hsa-miR-302d hsa-miR-765 hsa-miR-3138 hsa-miR-3653 hsa-miR-371-5p hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidEFNB3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for EFNB3
    Predesigned siRNA for gene silencing in human, mouse, rat EFNB3
    Clone
    Products:
         
    OriGene clones in human, mouse for EFNB3 (see all 7)
    OriGene ORF clones in mouse, rat for EFNB3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: EFNB3 (NM_001406)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EFNB3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EFNB3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for EFNB3
    OriGene qSTAR qPCR primer pairs in human, mouse for EFNB3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EFNB3
      QuantiTect SYBR Green Assays in human, mouse, rat EFNB3
      QuantiFast Probe-based Assays in human, mouse, rat EFNB3

    Additional mRNA sequence: 

    AK027329.1 AK314841.1 BC022499.1 BC042944.2 U57001.1 

    6 DOTS entries:

    DT.100813533  DT.445474  DT.91680350  DT.100813537  DT.120949968  DT.120950010 

    Selected AceView cDNA sequences (see all 67):

    BI913360 AI088793 BU554039 AA973977 NM_001406 BM974629 AA417565 BU859261 
    BU557245 BU854800 AW303554 U62775 BC042944 BI488464 BU741886 F01548 
    BU685648 BG751869 BG701666 BM677430 AA932672 AA055762 BX352973 BC022499 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    EFNB3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGCGGGAT
    EFNB3 Expression
    About this image


    EFNB3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 7 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
             Midbrain tegmentum
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 2 entries
             PureStem 4D20.8, NCr-fac Progenitor
     
     NULL (Uncategorized)
             Vascular endothelial growth factor-induced cells
     
     Umbilical Cord (Extraembryonic Tissues)
             Umbilical Arteries
    EFNB3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EFNB3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.26988

    UniProtKB/Swiss-Prot: EFNB3_HUMAN, Q15768
    Tissue specificity: Highly expressed in brain; expressed in embryonic floor plate, roof plate and hindbrain
    segments

        Custom PCR Arrays for EFNB3
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for EFNB3
    OriGene qSTAR qPCR primer pairs in human, mouse for EFNB3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EFNB3
    QuantiTect SYBR Green Assays in human, mouse, rat EFNB3
    QuantiFast Probe-based Assays in human, mouse, rat EFNB3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EFNB3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for EFNB3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Efnb31 , 5 ephrin B31, 5 91.96(n)1
    95.59(a)1
      11 (42.80 cM)5
    136431  NM_007911.51  NP_031937.11 
     695540925 
    lizard
    (Anolis carolinensis)
    Reptilia EFNB36
    ephrin-B3
    57(a)
    1 ↔ 1
    GL343655.1(233302-325411)
    African clawed frog
    (Xenopus laevis)
    Amphibia efnb3-A2 ephrin-B3 78.98(n)    AJ236866.1 
    zebrafish
    (Danio rerio)
    Actinopterygii efnb32 ephrin B3 78.64(n)   114378  AF375227.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ephrin6
    Ephrin
    10(a)
    1 → many
    4(592381-600748)
    worm
    (Caenorhabditis elegans)
    Secernentea efn-36
    efn-26
    (see all 3)
    Protein EFN-2 (efn-2) mRNA, complete cds
    (see all 3)
    29(a)
    26(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    X(13476101-13477456) WBGene00001164
    IV(10576350-10578286) WBGene00001163


    ENSEMBL Gene Tree for EFNB3 (if available)
    TreeFam Gene Tree for EFNB3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for EFNB3 gene
    EFNB12  EFNB22  
    2 SIMAP similar genes for EFNB3 using alignment to 1 protein entry:     EFNB3_HUMAN:
    EFNB2    EFNB1

    EFNB3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for EFNB3 (see all 160)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1869998861,2
    --7607351(+) AAAGGC/TGTTGA 1 -- us2k10--------
    rs1922920831,2
    --7607447(+) TTTCTC/TCATTT 1 -- us2k10--------
    rs99123341,2
    C--7607475(+) GGGTGG/AGGGAC 1 -- us2k11Minor allele frequency- A:0.00NA 2
    rs1123988691,2
    F--7607492(+) GTCATC/TTGAAG 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1860349401,2
    --7607516(+) CTCCTC/TCCCCC 1 -- us2k10--------
    rs1476134451,2
    --7607526(+) CAACAA/CCTTCC 1 -- us2k10--------
    rs1420921481,2
    --7607600(+) CACAAC/TCAAAG 1 -- us2k10--------
    rs1458537091,2
    --7607629(+) GGGGAA/GGCTTG 1 -- us2k10--------
    rs773126921,2
    C--7607743(+) TTCCTG/TCGCAG 1 -- us2k10--------
    rs1903608101,2
    --7608110(+) TCAAGA/GTTATT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for EFNB3 (7608520 - 7614696 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for EFNB3: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing EFNB3
    DNA2.0 Custom Variant and Variant Library Synthesis for EFNB3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 602297    OMIM disorders: --

    8 diseases for EFNB3:    
    About MalaCards
    lung cancer susceptibility    glioblastoma multiforme    neuroblastoma    osteosarcoma
    lung cancer    ovarian cancer    cerebritis    neuronitis


    EFNB3 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for EFNB3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    brain tumors 28.2 2 16596216 (1)
    glioma 23.2 4 16951161 (3), 15720813 (1)
    tumors 13.3 8 10984508 (1), 16596216 (1), 16951161 (1), 12695554 (1) (see all 5)

    Genetic Association Database (GAD): EFNB3
    Human Genome Epidemiology (HuGE) Navigator: EFNB3 (4 documents)

    Export disorders for EFNB3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for EFNB3 gene, integrated from 10 sources (see all 48):
    (articles sorted by number of sources associating them with EFNB3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning, chromosomal localization, and expression pattern of EPLG8, a new member of the EPLG gene family encoding ligands of EPH- related protein-tyrosine kinase receptors. (PubMed id 9126477)1, 2, 3, 9 Tang X.X.... Ikegaki N. (Genomics 1997)
    2. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    3. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (Environ. Mol. Mutagen. 2009)
    4. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1, 4 Hosgood H.D....Lan Q. (Carcinogenesis 2008)
    5. Two key residues in ephrinB3 are critical for its use as an alternative receptor for Nipah virus. (PubMed id 16477309)1, 2 Negrete O.A.... Lee B. (PLoS Pathog. 2006)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains. (PubMed id 10197531)1, 2 Brueckner K....Klein R. (Neuron 1999)
    10. Elk-L3, a novel transmembrane ligand for the Eph family of receptor tyrosine kinases, expressed in embryonic floor plate, roof plate and hindbrain segments. (PubMed id 8808709)1, 2 Gale N.W.... Yancopoulos G.D. (Oncogene 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 1949 HGNC: 3228 AceView: EFNB3 Ensembl:ENSG00000108947 euGenes: HUgn1949
    ECgene: EFNB3 Kegg: 1949 H-InvDB: EFNB3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for EFNB3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for EFNB3 gene:
    Search GeneIP for patents involving EFNB3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for EFNB3 (Ephrin-B3)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for EFNB3 (Ephrin-B3)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for EFNB3   OriGene RNAi products in human, mouse, rat for EFNB3  
     OriGene qPCR primer pairs and template standards for EFNB3   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for EFNB3  
     OriGene qSTAR qPCR primer pairs in human, mouse for EFNB3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for EFNB3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for EFNB3   OriGene Custom Protein Services for EFNB3  

     
     
     Block miRNA regulation of human, mouse, rat EFNB3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing EFNB3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EFNB3 Predesigned siRNA for gene silencing in human, mouse, rat EFNB3
     QuantiFast Probe-based Assays in human, mouse, rat EFNB3 QuantiTect SYBR Green Assays in human, mouse, rat EFNB3
     Custom PCR Arrays for EFNB3 Search Chromatin IP Primers for EFNB3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EFNB3  GeneGlobe Interaction Network for EFNB3
     Regulatory tfbs in EFNB3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for EFNB3 GenScript cDNA clones with any tag delivered in your preferred vector for EFNB3
     GenScript Custom Assay Services for EFNB3 GenScript Custom overexpressing Cell Line Services for EFNB3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for EFNB3 

     Search Tocris compounds for EFNB3
     Proteins for EFNB3
     Cell Lysates for EFNB3
     cDNA Clones for EFNB3
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     EFNB3 antibodies
     EFNB3 proteins
     Antibodies for EFNB3
     See all of Abcam's Antibodies, Kits and Proteins for EFNB3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for EFNB3
     Antibodies for EFNB3
     ELISAs for EFNB3
     CLIAs for EFNB3



     Browse ESI BIO Cell Lines and PureStem Progenitors for EFNB3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EFNB3
     SwitchGear 3'UTR luciferase reporter plasmids for EFNB3
     SwitchGear Promoter luciferase reporter plasmids for EFNB3
     ThermoFisher Antibodies for EFNB3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EFNB3
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EFNB3
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for EFNB3
     LSBio Antibodies in human, mouse, rat for EFNB3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      EFNB3 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4