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EFNB3 Gene

protein-coding GIFtS: 60

GC17P007549

ephrin-B3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: EPLG8)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EFL6 ^², ⁵
EPLG8 ^², ³, ⁵
LERK-8 ^¹, ³
LERK8 ^², ³, ⁵
ephrin-B3 ^²

Descriptions
EPH-related receptor transmembrane ligand ELK-L3 ^³
EPH-related receptor tyrosine kinase ligand 8 ^², ³
Ephrin B3 ^²

External Ids
HGNC: 3228¹
Entrez Gene: 1949²
UniProtKB: Q15768³
Ensembl: ENSG00000108947⁷

Search outside databases for aliases for EFNB3 gene

Previous GC identifers: GC17U990024 GC17P008348 GC17P007551 GC17P007809

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for EFNB3:

EFNB3, a member of the ephrin gene family, is important in brain development as well as in its

maintenance. Moreover, since levels of EFNB3 expression were particularly high in several

forebrain subregions compared to other brain subregions, it may play a pivotal role in forebrain

function. The EPH and EPH-related receptors comprise the largest subfamily of receptor

protein-tyrosine kinases and have been implicated in mediating developmental events, particularly

in the nervous system. EPH Receptors typically have a single kinase domain and an extracellular

region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and

receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and

sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to

the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are

transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on

the similarity of their extracellular domain sequences and their affinities for binding ephrin-A

and ephrin-B ligands. [provided by RefSeq]

UniProtKB/Swiss-Prot: EFNB3_HUMAN, Q15768

Function: May play a pivotal role in forebrain function. Binds to, and induce the collapse of,

commissural axons/growth cones in vitro. May play a role in constraining the orientation of

longitudinally projecting axons (By similarity)

Gene Wiki entry for EFNB3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the EFNB3 gene

Entrez Gene cytogenetic band: 17p13.1-p11.2 Ensembl cytogenetic band: 17p13.1 HGNC cytogenetic band: 17p13.1

EFNB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P007549: (about GC identifiers)

Start:	7,549,245 bp from pter
End:	7,555,418 bp from pter
Size:	6,174 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000017.9 NT_010718.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: EFNB3_HUMAN, Q15768 (See protein sequence)

Recommended Name: Ephrin-B3 precursor

Size: 340 amino acids; 35835 Da

Subunit: Interacts with GRIP1 and GRIP2. Binds to Nipah virus G protein

Subcellular location: Membrane; Single-pass type I membrane protein

Secondary accessions: O00680 Q8TBH7 Q92875

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001397.1

ENSEMBL proteins:

ENSP00000226091

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for EFNB3
	R&D Systems Recombinant & Natural Proteins for EFNB3 (Ephrin-B3)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Ephrin B3)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005887	integral to plasma membrane	TAS	9126477
GO:0016020	membrane	IEA	--

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Antibodies for EFNB3:

	Invitrogen Antibodies for EFNB3
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for EFNB3
	R&D Systems Antibodies for EFNB3 (Ephrin-B3)
	Antibodies from Abcam (Ephrin B3), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for EFNB3

Assays for EFNB3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q15768

ProtoNet protein and cluster: Q15768

1 Blocks protein family: IPB001799 Ephrin signature

UniProtKB/Swiss-Prot: EFNB3_HUMAN, Q15768

Similarity: Belongs to the ephrin family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (EFNB3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (EFNB3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001406

Applied Biosystems Silencer® siRNAs for EFNB3

Sigma-Aldrich siRNA and siRNA Panels for EFNB3

Sigma-Aldrich shRNA for EFNB3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for EFNB3
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001406
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001406
untagged cDNA clone in CMV expression vector: NM_001406

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001406

UniProtKB/Swiss-Prot: EFNB3_HUMAN, Q15768

Function: May play a pivotal role in forebrain function. Binds to, and induce the collapse of,

commissural axons/growth cones in vitro. May play a role in constraining the orientation of

longitudinally projecting axons (By similarity)

Genatlas biochemistry entry for EFNB3:

ephrin B-3,eph-related receptor tyrosine kinase,class B,ligand,involved in short-range

contact-mediated axonal guidance,expressed in fetal brain,and in adult forebrain

3 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Efnb3):

behavior/neurological

nervous system

normal

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005005	transmembrane-ephrin receptor activity	TAS	9126477
GO:0046875	ephrin receptor binding	IDA	8808709

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for EFNB3 (Your Favorite Gene powered by Ingenuity)

Ephrin Receptor Signaling
Axonal Guidance Signaling

GeneDecks EFNB3 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for EFNB3

5/32 Interacting proteins for EFNB3 (ENSP00000226091³) via UniProtKB, MINT, and/or STRING (see all 32 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EPHA4	ENSP00000281821³	STRING (score=.998)
EPHB3	ENSP00000332118³	STRING (score=.992)
EPHB2	ENSP00000363761³	STRING (score=.984)
EPHB1	ENSP00000354191³	STRING (score=.982)
EPHB6	ENSP00000222847³	STRING (score=.977)

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5/8 Gene Ontology (GO) biological process terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007267	cell-cell signaling	TAS	9126477
GO:0007275	multicellular organismal development	IEA	--
GO:0007399	nervous system development	TAS	9126477
GO:0007628	adult walking behavior	IEA	--
GO:0016198	axon choice point recognition	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for EFNB3
1 Novoseek chemical compound relationship for EFNB3 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	36.66	5	15720813 (1), 9126477 (1), 16951161 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (EFNB3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (EFNB3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001406

Sigma-Aldrich siRNA and siRNA Panels for EFNB3

Sigma-Aldrich shRNA for EFNB3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001406

REFSEQ mRNAs for EFNB3 gene:

NM_001406.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001406

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001406
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001406
                                 untagged cDNA clone in CMV expression vector: NM_001406

Additional cDNA sequence:

AK027329.1 AK314841.1 BC022499.1 BC042944.2 U57001.1

6 DOTS entries:

DT.100813533 DT.445474 DT.91680350 DT.100813537 DT.120949968 DT.120950010

24/67 AceView cDNA sequences (see all 67 ):

AA973977 BU859261 BU557245 BM974629 AI088793 NM_001406 BU854800 BI913360

BU554039 AA417565 BI488464 AA932672 AA291485 BU685648 BG751869 BC042944

BX352973 BM971890 AI350400 AW303554 F01548 T09017 AA055762 BG701666

highest scoring ESTs for EFNB3:

AA055762 AA219737 AA291485 AA404693 AA417565 AA417681 AA485665 AA485795 AA875969 AA973977

Unigene Cluster for EFNB3:

Ephrin-B3

Hs.26988 [show with all ESTs]

Unigene Representative Sequence: NM_001406

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000226091

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

EFNB3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for EFNB3

¹ / ² / ³

5 probe-sets matching EFNB3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
469_at²^{, 3}	U95-A	2	1.00	0.97	1.00	1.00	U66406	0.80	1.00	0.91	1
210883_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U57001	0.80	1.00	0.91	1
205031_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001406	0.60	1.00	0.82	1
210883_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
205031_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks EFNB3 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTGGCGGGAT

SOURCE GeneReport for Unigene cluster: Hs.26988
Expression variation in blood from EXPOLDB for EFNB3
UniProtKB/Swiss-Prot: EFNB3_HUMAN, Q15768
Tissue specificity: Highly expressed in brain; expressed in embryonic floor plate, roof plate and
hindbrain segments

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for EFNB3 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	EFNB3¹	--	ephrin-B3	93.61(n) 97.01(a)	607903 XM_844752.1 XP_849845.1
chimpanzee (Pan troglodytes)	EFNB3¹	--	ephrin-B3	99.65(n) 100(a)	750632 XM_001174846.1 XP_001174846.1
cow (Bos taurus)	EFNB3¹	--	ephrin-B3	94.71(n) 96.76(a)	617714 XM_870023.2 XP_875116.1
rat (Rattus norvegicus)	Efnb3¹	--	ephrin B3	93.43(n) 96.76(a)	360546 XM_340824.3 XP_340825.1
mouse (Mus musculus)	Efnb3^{1, 5}	11 (40.00 cM)⁵	ephrin B3^{1, 5}	91.96(n)¹ 95.59(a)¹	13643¹ NM_007911.4¹ NP_031937.1¹ AF025288⁵ AK048305⁵ (see all 13)

About this table Species with no ortholog for EFNB3

ENSEMBL Gene Tree for EFNB3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for EFNB3 gene

EFNB1² EFNB2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/21 NCBI SNPs in EFNB3 are shown (see all 21 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 47)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs7141^1,2	A,C,F,H	7555326(+)	`GCGGGA/GTATGC`	1	--	ut3¹ ese³		15		MN EA NA EU WA	2890
	rs3744262^1,2	A,C,F,H	7554490(-)	`CTGTCC/TGGGCC`	1	--	ut3¹ ese³		10		EA MN CSAM EU WA	2288
	rs3744263^1,2	C,F,H	7554433(-)	`CATTCG/AGCATC`	1	--	ut3¹ ese³		13		EA NA MN CSAM EU	2190
	rs12941981^1,2	C,F,H	7549187(+)	`CCCTCC/AACCAT`	1	--	ng5¹ trp³		4		EU EA WA	352
	rs3744264^1,2	F	7553972(-)	`GGCGGT/CGCCAA`	1	--	ut3¹		1		EA	1474
	rs12451095^1,2	H	7552850(+)	`CCTGCC/AGTCAC`	1	--	int¹		4		EU EA WA	418
--	rs9912334^1,2	--	7548200(+)	`GGGTGA/GGGGAC`	1	--	ng5¹		0	--	--	--	--
--	rs3210553^1,2	--	7555416(+)	`gttgaA/Caaaaa`	1	--	ut3¹		0	--	--	--	--
--	rs71387990^1,2	--	7548233(+)	`CTCCT-/CCCCTC`	1	--	ng5¹		0	--	--	--	--
--	rs8072235^1,2	--	7549170(+)	`CTCCAA/GCTCCG`	1	--	ng5¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for EFNB3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 602297

3 Novoseek disease relationships for EFNB3 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
brain tumors	31.03	2	16596216 (1)
glioma	26.17	4	16951161 (3), 15720813 (1)
tumors	16.55	8	10984508 (1), 16596216 (1), 16951161 (1), 12695554 (1) (see all 5)

About this table

Human Genome Epidemiology Navigator: EFNB3 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/39 PubMed articles for EFNB3 gene (see all 39 ):

cDNA cloning, chromosomal localization, and expression pattern of EPLG8, a new member of the EPLG gene family encoding ligands of EPH- related protein-tyrosine kinase receptors. (PubMed id 9126477)^{1, 2, 3, 4} Tang X.X.... Ikegaki N. (1997)
Two key residues in ephrinB3 are critical for its use as an alternative receptor for Nipah virus. (PubMed id 16477309)^{3, 4} Negrete O.A....Lee B. (2006)
Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{3, 4} Zhang Z. and Henzel W.J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains. (PubMed id 10197531)^{3, 4} Brueckner K....Klein R. (1999)
Elk-L3, a novel transmembrane ligand for the Eph family of receptor tyrosine kinases, expressed in embryonic floor plate, roof plate and hindbrain segments. (PubMed id 8808709)^{3, 4} Gale N.W.... Yancopoulos G.D. (1996)
Ephrin-B3 ligand promotes glioma invasion through activation of Rac1. (PubMed id 16951161)^{1, 3} Nakada M....Berens M.E. (2006)
Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)³ Hosgood H.D....Lan Q. (2008)
Host cell recognition by the henipaviruses: crystal structures of the Nipah G attachment glycoprotein and its complex with ephrin-B3. (PubMed id 18632560)³ Xu K....Nikolov D.B. (2008)
EphB receptors regulate stem/progenitor cell proliferation, migration, and polarity during hippocampal neurogenesis. (PubMed id 18057206)³ Chumley M.J....Henkemeyer M. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 1949	HGNC: 3228	AceView: EFNB3	Ensembl:ENSG00000108947	euGenes: HUgn1949
ECgene: EFNB3	H-InvDB: EFNB3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for EFNB3
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for EFNB3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for EFNB3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for EFNB3		Antibodies for EFNB3
	Explore super-pooled esiRNAs		Proteins for EFNB3
	Lentivirus-delivered shRNAs for EFNB3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Search Novus for antibodies for EFNB3

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EFNB3 Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for EFNB3

Summaries
for EFNB3

Genomic Location
for EFNB3

Proteins
for EFNB3

Protein Domains/
Families
for EFNB3

Gene Function
for EFNB3

Pathways & Interactions
for EFNB3

Drugs & Compounds
for EFNB3

Transcripts
for EFNB3

Expression
for EFNB3

Orthologs
for EFNB3

Paralogs
for EFNB3

SNPs/Variants
for EFNB3

Disorders & Mutations
for EFNB3

Medical News
for EFNB3

Publications
for EFNB3

Search for EFNB3

Genome Databases showing EFNB3

Other Databases showing EFNB3

Specialized Databases showing EFNB3

Licensable Technologies
for EFNB3

Services
for EFNB3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

EFNB3 Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor EFNB3

Summariesfor EFNB3

Genomic Locationfor EFNB3

Proteinsfor EFNB3

Protein Domains/Familiesfor EFNB3

Gene Functionfor EFNB3

Pathways & Interactionsfor EFNB3

Drugs & Compoundsfor EFNB3

Transcriptsfor EFNB3

Expression for EFNB3

Orthologsfor EFNB3

Paralogsfor EFNB3

SNPs/Variantsfor EFNB3

Disorders & Mutationsfor EFNB3

Medical Newsfor EFNB3

Publicationsfor EFNB3

Search for EFNB3

Genome Databases showing EFNB3

Other Databases showing EFNB3

Specialized Databases showing EFNB3

Licensable Technologiesfor EFNB3

Servicesfor EFNB3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for EFNB3

Summaries
for EFNB3

Genomic Location
for EFNB3

Proteins
for EFNB3

Protein Domains/
Families
for EFNB3

Gene Function
for EFNB3

Pathways & Interactions
for EFNB3

Drugs & Compounds
for EFNB3

Transcripts
for EFNB3

Expression
for EFNB3

Orthologs
for EFNB3

Paralogs
for EFNB3

SNPs/Variants
for EFNB3

Disorders & Mutations
for EFNB3

Medical News
for EFNB3

Publications
for EFNB3

Licensable Technologies
for EFNB3

Services
for EFNB3