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Aliases for EFNB3 Gene

Aliases for EFNB3 Gene

  • Ephrin B3 2 3
  • EPH-Related Receptor Transmembrane Ligand ELK-L3 3 4
  • Ephrin-B3 2 5
  • EPLG8 3 4
  • LERK8 3 4
  • Eph-Related Receptor Tyrosine Kinase Ligand 8 3
  • EPH-Related Receptor Tyrosine Kinase Ligand 8 4
  • LERK-8 4
  • EFL6 3

External Ids for EFNB3 Gene

Previous HGNC Symbols for EFNB3 Gene

  • EPLG8

Previous GeneCards Identifiers for EFNB3 Gene

  • GC17U990024
  • GC17P008348
  • GC17P007551
  • GC17P007809
  • GC17P007549
  • GC17P007608
  • GC17P007501

Summaries for EFNB3 Gene

Entrez Gene Summary for EFNB3 Gene

  • EFNB3, a member of the ephrin gene family, is important in brain development as well as in its maintenance. Moreover, since levels of EFNB3 expression were particularly high in several forebrain subregions compared to other brain subregions, it may play a pivotal role in forebrain function. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH Receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. [provided by RefSeq, Jul 2008]

GeneCards Summary for EFNB3 Gene

EFNB3 (Ephrin B3) is a Protein Coding gene. Among its related pathways are Axon guidance and Angiogenesis (CST). GO annotations related to this gene include ephrin receptor binding and transmembrane-ephrin receptor activity. An important paralog of this gene is EFNB2.

UniProtKB/Swiss-Prot for EFNB3 Gene

  • Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity).

  • (Microbial infection) Acts as a receptor for nipah virus and hendra virus.

Gene Wiki entry for EFNB3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EFNB3 Gene

Genomics for EFNB3 Gene

Regulatory Elements for EFNB3 Gene

Enhancers for EFNB3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around EFNB3 on UCSC Golden Path with GeneCards custom track

Genomic Location for EFNB3 Gene

Chromosome:
17
Start:
7,705,202 bp from pter
End:
7,711,378 bp from pter
Size:
6,177 bases
Orientation:
Plus strand

Genomic View for EFNB3 Gene

Genes around EFNB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EFNB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EFNB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EFNB3 Gene

Proteins for EFNB3 Gene

  • Protein details for EFNB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15768-EFNB3_HUMAN
    Recommended name:
    Ephrin-B3
    Protein Accession:
    Q15768
    Secondary Accessions:
    • B2RBW2
    • D3DTQ6
    • O00680
    • Q8TBH7
    • Q92875

    Protein attributes for EFNB3 Gene

    Size:
    340 amino acids
    Molecular mass:
    35835 Da
    Quaternary structure:
    • Interacts with GRIP1 and GRIP2.
    • (Microbial infection) Interacts with nipah virus and hendra virus glycoprotein (PubMed:16477309, PubMed:17376907).

    Three dimensional structures from OCA and Proteopedia for EFNB3 Gene

neXtProt entry for EFNB3 Gene

Proteomics data for EFNB3 Gene at MOPED

Post-translational modifications for EFNB3 Gene

  • Glycosylation at Asn 210
  • Modification sites at PhosphoSitePlus

Other Protein References for EFNB3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for EFNB3 (EFNB3)

No data available for DME Specific Peptides for EFNB3 Gene

Domains & Families for EFNB3 Gene

Gene Families for EFNB3 Gene

Protein Domains for EFNB3 Gene

Suggested Antigen Peptide Sequences for EFNB3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15768

UniProtKB/Swiss-Prot:

EFNB3_HUMAN :
  • Contains 1 ephrin RBD (ephrin receptor-binding) domain.
  • Belongs to the ephrin family.
Domain:
  • Contains 1 ephrin RBD (ephrin receptor-binding) domain.
Family:
  • Belongs to the ephrin family.
genes like me logo Genes that share domains with EFNB3: view

Function for EFNB3 Gene

Molecular function for EFNB3 Gene

GENATLAS Biochemistry:
ephrin B-3,eph-related receptor tyrosine kinase,class B,ligand,involved in short-range contact-mediated axonal guidance,expressed in fetal brain,and in adult forebrain
UniProtKB/Swiss-Prot Function:
Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for nipah virus and hendra virus.
genes like me logo Genes that share phenotypes with EFNB3: view

Animal Models for EFNB3 Gene

MGI Knock Outs for EFNB3:

Animal Model Products

miRNA for EFNB3 Gene

miRTarBase miRNAs that target EFNB3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EFNB3 Gene

Localization for EFNB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EFNB3 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EFNB3 Gene COMPARTMENTS Subcellular localization image for EFNB3 gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for EFNB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with EFNB3: view

Pathways & Interactions for EFNB3 Gene

genes like me logo Genes that share pathways with EFNB3: view

Pathways by source for EFNB3 Gene

2 Cell Signaling Technology pathways for EFNB3 Gene
1 BioSystems pathway for EFNB3 Gene
1 KEGG pathway for EFNB3 Gene
2 Qiagen pathways for EFNB3 Gene

SIGNOR curated interactions for EFNB3 Gene

Activates:

Gene Ontology (GO) - Biological Process for EFNB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007267 cell-cell signaling TAS 9126477
GO:0007411 axon guidance IEA,IBA --
GO:0007628 adult walking behavior IEA --
GO:0016198 axon choice point recognition IEA --
GO:0046718 viral entry into host cell IEA --
genes like me logo Genes that share ontologies with EFNB3: view

Drugs & Compounds for EFNB3 Gene

(1) Drugs for EFNB3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with EFNB3: view

Transcripts for EFNB3 Gene

mRNA/cDNA for EFNB3 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(67) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EFNB3 Gene

Ephrin-B3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EFNB3 Gene

No ASD Table

Relevant External Links for EFNB3 Gene

GeneLoc Exon Structure for
EFNB3
ECgene alternative splicing isoforms for
EFNB3

Expression for EFNB3 Gene

mRNA expression in normal human tissues for EFNB3 Gene

mRNA differential expression in normal tissues according to GTEx for EFNB3 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x6.5), Brain - Anterior cingulate cortex (BA24) (x5.3), Brain - Cortex (x4.9), Brain - Hypothalamus (x4.9), Brain - Frontal Cortex (BA9) (x4.4), and Brain - Caudate (basal ganglia) (x4.1).

Protein differential expression in normal tissues from HIPED for EFNB3 Gene

This gene is overexpressed in Bone (35.7), Pancreatic juice (12.2), Fetal Brain (12.2), and Platelet (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for EFNB3 Gene



SOURCE GeneReport for Unigene cluster for EFNB3 Gene Hs.26988

mRNA Expression by UniProt/SwissProt for EFNB3 Gene

Q15768-EFNB3_HUMAN
Tissue specificity: Highly expressed in brain; expressed in embryonic floor plate, roof plate and hindbrain segments.
genes like me logo Genes that share expression patterns with EFNB3: view

Protein tissue co-expression partners for EFNB3 Gene

Primer Products

In Situ Assay Products

Orthologs for EFNB3 Gene

This gene was present in the common ancestor of animals.

Orthologs for EFNB3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EFNB3 35
  • 94.71 (n)
  • 96.76 (a)
EFNB3 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EFNB3 35
  • 93.43 (n)
  • 96.72 (a)
EFNB3 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Efnb3 35
  • 91.96 (n)
  • 95.59 (a)
Efnb3 16
Efnb3 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Efnb3 35
  • 93.43 (n)
  • 96.76 (a)
oppossum
(Monodelphis domestica)
Mammalia EFNB3 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EFNB3 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EFNB3 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia efnb3 35
  • 62.64 (n)
  • 62.08 (a)
African clawed frog
(Xenopus laevis)
Amphibia efnb3-A 35
zebrafish
(Danio rerio)
Actinopterygii efnb3 35
efnb3b 35
  • 60 (n)
  • 58.33 (a)
efnb3a 36
  • 50 (a)
OneToMany
efnb3b 36
  • 53 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Ephrin 36
  • 10 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea efn-2 36
  • 26 (a)
ManyToMany
efn-3 36
  • 29 (a)
ManyToMany
vab-2 36
  • 24 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7000 36
  • 25 (a)
OneToMany
Species with no ortholog for EFNB3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EFNB3 Gene

ENSEMBL:
Gene Tree for EFNB3 (if available)
TreeFam:
Gene Tree for EFNB3 (if available)

Paralogs for EFNB3 Gene

Paralogs for EFNB3 Gene

(2) SIMAP similar genes for EFNB3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with EFNB3: view

Variants for EFNB3 Gene

Sequence variations from dbSNP and Humsavar for EFNB3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_002356 -
rs7141 -- 7,711,283(+) GCGGG(A/G)TATGC utr-variant-3-prime
rs2229847 -- 7,709,386(+) CCTGG(A/G)GGGTG reference, missense
rs2287496 -- 7,708,766(+) CCTGC(C/T)TTCCC intron-variant
rs3744262 -- 7,710,447(-) CTGTC(C/T)GGGCC utr-variant-3-prime

Variation tolerance for EFNB3 Gene

Residual Variation Intolerance Score: 22.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.99; 36.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EFNB3 Gene

HapMap Linkage Disequilibrium report
EFNB3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for EFNB3 Gene

Disorders for EFNB3 Gene

Relevant External Links for EFNB3

Genetic Association Database (GAD)
EFNB3
Human Genome Epidemiology (HuGE) Navigator
EFNB3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EFNB3

No disorders were found for EFNB3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EFNB3 Gene

Publications for EFNB3 Gene

  1. cDNA cloning, chromosomal localization, and expression pattern of EPLG8, a new member of the EPLG gene family encoding ligands of EPH- related protein-tyrosine kinase receptors. (PMID: 9126477) Tang X.X. … Ikegaki N. (Genomics 1997) 2 3 4 23 67
  2. Ephrin-B3 ligand promotes glioma invasion through activation of Rac1. (PMID: 16951161) Nakada M. … Berens M.E. (Cancer Res. 2006) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Discerning intersecting fusion-activation pathways in the Nipah virus using machine learning. (PMID: 24615845) Varma S. … Leighty R.E. (Proteins 2014) 3
  5. Phosphoproteomic profiling of NSCLC cells reveals that ephrin B3 regulates pro-survival signaling through Akt1-mediated phosphorylation of the EphA2 receptor. (PMID: 21413766) StAYhl S. … LehtiAP J. (J. Proteome Res. 2011) 3

Products for EFNB3 Gene

Sources for EFNB3 Gene

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