Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



EFNB2 Gene

protein-coding   GIFtS: 67
GCID: GC13M107142

Ephrin-B2


(Previous symbol: EPLG5)
  See EFNB2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
ephrin-B21 2     LERK52 3 5
EPLG51 2 3 5     Ligand Of Eph-Related Kinase 51 2
HTK Ligand1 2 3     LERK-52 3
EPH-Related Receptor Tyrosine Kinase Ligand 51 2 3     Htk-L2
HTKL2 3 5     HTK-L3

External Ids:    HGNC: 32271   Entrez Gene: 19482   Ensembl: ENSG000001252667   OMIM: 6005275   UniProtKB: P527993   

Export aliases for EFNB2 gene to outside databases

Previous GC identifers: GC13M105503 GC13M101530 GC13M105980 GC13M104840 GC13M105940 GC13M087733


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for EFNB2 Gene:
This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest
subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events,
especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships,
ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a
glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene
encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors. (provided by RefSeq, Jul 2008)

GeneCards Summary for EFNB2 Gene:
EFNB2 (ephrin-B2) is a protein-coding gene. Diseases associated with EFNB2 include craniofrontonasal syndrome. GO annotations related to this gene include ephrin receptor binding. An important paralog of this gene is EFNB1.

UniProtKB/Swiss-Prot: EFNB2_HUMAN, P52799
Function: Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are
crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds
promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into
neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the
signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine
kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and
angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls
cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation
of longitudinally projecting axons

Gene Wiki entry for EFNB2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NC_018924.2  NT_009952.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the EFNB2 gene promoter:
         Oct-B1   NF-1   NF-1/L   oct-B2   oct-B3   IRF-1   POU2F2   GATA-1   IRF-2   POU2F1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEFNB2 promoter sequence
   Search Chromatin IP Primers for EFNB2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EFNB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q33   Ensembl cytogenetic band:  13q33.3   HGNC cytogenetic band: 13q33

EFNB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EFNB2 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M107142:  view genomic region     (about GC identifiers)

Start:
107,142,079 bp from pter      End:
107,187,462 bp from pter
Size:
45,384 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: EFNB2_HUMAN, P52799 (See protein sequence)
Recommended Name: Ephrin-B2 precursor  
Size: 333 amino acids; 36923 Da
Subunit: Interacts with PDZRN3 (By similarity). Binds to the receptor tyrosine kinases EPHA4, EPHB4 and EPHA3.
Binds to Hendra virus and Nipah virus G protein
6 PDB 3D structures from and Proteopedia for EFNB2:
2HLE (3D)        2I85 (3D)        2VSK (3D)        2VSM (3D)        2WO2 (3D)        3GXU (3D)    
Secondary accessions: Q5JV56

Explore the universe of human proteins at neXtProt for EFNB2: NX_P52799

Explore proteomics data for EFNB2 at MOPED

Post-translational modifications: 

  • Inducible phosphorylation of tyrosine residues in the cytoplasmic domain (By similarity)1
  • Glycosylation2 at Asn36, Asn139, Thr180, Thr189
  • Modification sites at PhosphoSitePlus

  • See EFNB2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004084.1  
    ENSEMBL proteins: 
     ENSP00000245323  

    EFNB2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for EFNB2 (Ephrin-B2)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for EFNB2
    OriGene Protein Over-expression Lysate for EFNB2
    OriGene MassSpec for EFNB2
    OriGene Custom Protein Services for EFNB2
    GenScript Custom Purified and Recombinant Proteins Services for EFNB2
    Novus Biologicals EFNB2 Proteins
    Novus Biologicals EFNB2 Lysate
    Sino Biological Recombinant Protein for EFNB2
    Sino Biological Cell Lysate for EFNB2
    ProSpec Recombinant Protein for EFNB2
    Cloud-Clone Corp. Proteins for EFNB2

     
    Search eBioscience for Proteins for EFNB2 

     
    antibodies-online proteins for EFNB2 (17 products) 

     
    antibodies-online peptides for EFNB2

    EFNB2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of EFNB2
    R&D Systems Antibodies for EFNB2 (Ephrin-B2)
    Cell Signaling Technology (CST) Antibodies for EFNB2 
    OriGene Antibodies for EFNB2
    OriGene Custom Antibody Services for EFNB2
    Novus Biologicals EFNB2 Antibodies
    Abcam antibodies for EFNB2 (P52799, P98172)
    Cloud-Clone Corp. Antibodies for EFNB2
    ThermoFisher Antibodies for EFNB2
    antibodies-online antibodies for EFNB2 (59 products) 

    EFNB2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for EFNB2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for EFNB2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for EFNB2
    Cloud-Clone Corp. CLIAs for EFNB2
    Search eBioscience for ELISAs for EFNB2 
    antibodies-online kits for EFNB2 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    EFN: Ephrins

    3 InterPro protein domains:
     IPR001799 Ephrin
     IPR008972 Cupredoxin
     IPR019765 Ephrin_CS

    Graphical View of Domain Structure for InterPro Entry P52799

    ProtoNet protein and cluster: P52799

    1 Blocks protein domain: IPB001799 Ephrin signature

    UniProtKB/Swiss-Prot: EFNB2_HUMAN, P52799
    Similarity: Belongs to the ephrin family
    Similarity: Contains 1 ephrin RBD (ephrin receptor-binding) domain


    Find genes that share domains with EFNB2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EFNB2_HUMAN, P52799
    Function: Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are
    crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds
    promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into
    neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the
    signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine
    kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and
    angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls
    cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation
    of longitudinally projecting axons

         Genatlas biochemistry entry for EFNB2:
    ephrin B-2,eph-related receptor tyrosine kinase,class B,ligand,high affinity,involved in short-range
    contact-mediated axonal guidance,also involved in angiogenesis by marking arterial but not venous endothelial
    cells

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding ----
    GO:0005515protein binding IPI12606549
    GO:0046875ephrin receptor binding IPI16867992
         
    Find genes that share ontologies with EFNB2           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for EFNB2:
     Decreased TP53 protein express  Decreased viability with pacli  Synthetic lethal with Ras 

         Selected MGI mutant phenotypes (inferred from 19 alleles(MGI details for Efnb2) (see all 23):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear  hematopoietic system 
     homeostasis/metabolism  immune system  integument  mortality/aging  muscle 

    Find genes that share phenotypes with EFNB2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for EFNB2: Efnb2tm5Kln Efnb2tm1.1Henk

       genOway: Develop your customized and physiologically relevant rodent model for EFNB2

    miRNA
    Products:
        
    miRTarBase miRNAs that target EFNB2:
    hsa-mir-215-5p (MIRT024662), hsa-mir-16-5p (MIRT032048), hsa-mir-103a-3p (MIRT027181), hsa-mir-192-5p (MIRT026948), hsa-mir-331-3p (MIRT043356), hsa-mir-204-5p (MIRT007101), hsa-mir-218-5p (MIRT024211), hsa-mir-375 (MIRT020031), hsa-mir-96-5p (MIRT027920), hsa-mir-20b-5p (MIRT006337)

    Block miRNA regulation of human, mouse, rat EFNB2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EFNB2 (see all 122):
    hsa-miR-3152-3p hsa-miR-520e hsa-miR-300 hsa-miR-188-5p hsa-miR-15a hsa-miR-106a hsa-miR-3653 hsa-miR-219-5p
    SwitchGear 3'UTR luciferase reporter plasmidEFNB2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for EFNB2
    Predesigned siRNA for gene silencing in human, mouse, rat EFNB2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for EFNB2

    Clone
    Products:
         
    OriGene clones in human, mouse for EFNB2 (see all 7)
    OriGene ORF clones in mouse, rat for EFNB2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: EFNB2 (NM_004093)
    Sino Biological Human cDNA Clone for EFNB2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EFNB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EFNB2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for EFNB2
    Browse ESI BIO Cell Lines and PureStem Progenitors for EFNB2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EFNB2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    EFNB2_HUMAN, P52799: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    peroxisome2
    cytoskeleton1
    cytosol1
    extracellular1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IBA--
    GO:0005887integral component of plasma membrane TAS8660976
    GO:0016020membrane ----

    Find genes that share ontologies with EFNB2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for EFNB2 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1EphB-EphrinB Signaling
    EphB-EphrinB Signaling0.58
    Cytoskeleton remodeling Reverse signaling by ephrin B0.34
    Ephrin-Eph Signaling0.58
    2EPHB forward signaling
    EPHB forward signaling0.30
    EphrinB-EPHB pathway0.00
    Cell adhesion Ephrins signaling0.30
    3Tyrosine Kinases / Adaptors
    Tyrosine Kinases / Adaptors
    4Spinal Cord Injury
    Spinal Cord Injury
    5Ephrin B reverse signaling
    Ephrin B reverse signaling


    Find genes that share SuperPaths with EFNB2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for EFNB2
        EphB-EphrinB Signaling
    Ephrin-Eph Signaling

    2 Cell Signaling Technology (CST) Pathways for EFNB2
        Angiogenesis
    Tyrosine Kinases / Adaptors

    2 GeneGo (Thomson Reuters) Pathways for EFNB2
        Cytoskeleton remodeling Reverse signaling by ephrin B
    Cell adhesion Ephrins signaling

    4 BioSystems Pathways for EFNB2
        Spinal Cord Injury
    Ephrin B reverse signaling
    EPHB forward signaling
    EphrinB-EPHB pathway



    1 Kegg Pathway  (Kegg details for EFNB2):
        Axon guidance

        Pathway & Disease-focused RT2 Profiler PCR Arrays including EFNB2: 
              Terminal Differentiation Markers in human mouse rat
              Angiogenesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for EFNB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for EFNB2 (P527991, 2, 3 ENSP000002453234) via UniProtKB, MINT, STRING, and/or I2D (see all 50)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCK2O436391, 2, 3, ENSP000002331544EBI-7532268,EBI-713635 MINT-8036407 MINT-8038295 MINT-8027798 MINT-8027813 MINT-8038280 MINT-8027783 MINT-8038342 I2D: score=2 STRING: ENSP00000233154
    EPHB1P547623, ENSP000003810974I2D: score=2 STRING: ENSP00000381097
    EPHB6O151973, ENSP000003766844I2D: score=1 STRING: ENSP00000376684
    GRM5P415943, ENSP000003061384I2D: score=1 STRING: ENSP00000306138
    HOMER1Q86YM73, ENSP000003343824I2D: score=1 STRING: ENSP00000334382
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001945lymph vessel development IEA--
    GO:0002042cell migration involved in sprouting angiogenesis IDA12734395
    GO:0007155cell adhesion IDA12734395
    GO:0007267cell-cell signaling TAS8559144
    GO:0007399nervous system development ----

    Find genes that share ontologies with EFNB2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EFNB2

    1 DrugBank Compound for EFNB2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Alpha-D-Mannose-- 3458-28-4target--10592235

    3 Novoseek inferred chemical compound relationships for EFNB2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 56 6 19728339 (1), 9259557 (1), 16413489 (1), 10221518 (1) (see all 5)
    vegf 26.6 6 16951162 (3), 15603710 (2), 15471957 (1)
    retinoic acid 0 4 15318809 (1)



    Find genes that share compounds with EFNB2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for EFNB2 gene: 
    NM_004093.3  

    Unigene Cluster for EFNB2:

    Ephrin-B2
    Hs.149239  [show with all ESTs]
    Unigene Representative Sequence: NM_004093
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000245323(uc001vqi.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat EFNB2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EFNB2 (see all 122):
    hsa-miR-3152-3p hsa-miR-520e hsa-miR-300 hsa-miR-188-5p hsa-miR-15a hsa-miR-106a hsa-miR-3653 hsa-miR-219-5p
    SwitchGear 3'UTR luciferase reporter plasmidEFNB2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for EFNB2
    Predesigned siRNA for gene silencing in human, mouse, rat EFNB2
    Clone
    Products:
         
    OriGene clones in human, mouse for EFNB2 (see all 7)
    OriGene ORF clones in mouse, rat for EFNB2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: EFNB2 (NM_004093)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EFNB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EFNB2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for EFNB2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EFNB2
      QuantiTect SYBR Green Assays in human, mouse, rat EFNB2
      QuantiFast Probe-based Assays in human, mouse, rat EFNB2

    Additional mRNA sequence: 

    BC069342.1 BC074856.2 BC074857.2 BC105955.1 BC105956.1 BC105957.1 L38734.1 U16797.1 
    U81262.1 

    6 DOTS entries:

    DT.446863  DT.120772470  DT.100746826  DT.40111143  DT.100783872  DT.95275439 

    Selected AceView cDNA sequences (see all 200):

    CD677139 BC069342 BU621951 BC074857 AU280529 AI335696 CN483205 AI335686 
    AI473559 BM725282 AW073287 AI827241 AW192736 BC074856 AA461108 BM682187 
    AA938595 CR609389 AI248016 AA255466 BG697913 BU152920 BF110667 BQ433342 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    EFNB2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATATTTATT
    EFNB2 Expression
    About this image


    EFNB2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 14) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 8 entries
             Arterial Endothelial Cells Arteries
             Endothelial-like cells
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Arterial Endothelial Cells Pulmonary Capillary Plexus
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             Arterial Endothelial Cells Paired Dorsal Aorta
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Telencephalon
     
     Heart (Cardiovascular System)
             Arterial Endothelial Cells Dorsal Aorta
    EFNB2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EFNB2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.149239

    UniProtKB/Swiss-Prot: EFNB2_HUMAN, P52799
    Tissue specificity: Lung and kidney

        Pathway & Disease-focused RT2 Profiler PCR Arrays including EFNB2: 
              Terminal Differentiation Markers in human mouse rat
              Angiogenesis in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for EFNB2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EFNB2
    QuantiTect SYBR Green Assays in human, mouse, rat EFNB2
    QuantiFast Probe-based Assays in human, mouse, rat EFNB2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EFNB2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for EFNB2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Efnb21 , 5 ephrin B21, 5 93.03(n)1
    96.97(a)1
      8 (3.42 cM)5
    136421  NM_010111.51  NP_034241.21 
     86174345 
    chicken
    (Gallus gallus)
    Aves EFNB21 ephrin-B2 83.33(n)
    90(a)
      395625  NM_204824.1  NP_990155.1 
    lizard
    (Anolis carolinensis)
    Reptilia EFNB26
    ephrin-B2
    81(a)
    1 ↔ 1
    3(103536017-103608063)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC688902 hypothetical protein MGC68890 77.33(n)    BC057724.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AF375226.12   -- 76.23(n)   114402  AF375226.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ephrin6
    Ephrin
    12(a)
    1 → many
    4(592381-600748)
    worm
    (Caenorhabditis elegans)
    Secernentea efn-26
    efn-36
    (see all 3)
    Protein EFN-3 (efn-3) mRNA, complete cds
    (see all 3)
    29(a)
    28(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    IV(10576350-10578286) WBGene00001163
    X(13476101-13477456) WBGene00001164


    ENSEMBL Gene Tree for EFNB2 (if available)
    TreeFam Gene Tree for EFNB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for EFNB2 gene
    EFNB12  EFNB32  
    2 SIMAP similar genes for EFNB2 using alignment to 2 protein entries:     EFNB2_HUMAN (see all proteins):
    EFNB1    EFNB3

    Find genes that share paralogs with EFNB2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for EFNB2 (see all 939)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1877708221,2
    --107141676(+) TAGACC/TGCTGC 1 -- ds50010--------
    rs73293571,2
    C,F,A,H--107141705(+) AGATCG/AATCTG 1 -- ds500117Minor allele frequency- A:0.43NA NS EA WA CSA 929
    rs1143948221,2
    C,F--107141731(+) TAAGAG/ATACAT 1 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1485629751,2
    --107141749(+) TTTTTC/TCTGAG 1 -- ds50010--------
    rs341340521,2
    --107141918(+) AATTAA/GTATTT 1 -- ds50010--------
    rs1856857681,2
    C--107141942(+) ATCCCA/GATTTG 1 -- ds50010--------
    rs1877751031,2
    --107141945(+) CCGATG/TTGAAA 1 -- ds50010--------
    rs1455183421,2
    --107142012(+) AAATAC/GAGTAA 1 -- ds50010--------
    rs1126801901,2
    C--107142043(+) CAAACAA/-AAAAG 1 -- ds50011Minor allele frequency- -:0.50CSA 2
    rs1919261481,2
    --107142054(+) GAAAGA/GAAAAT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for EFNB2 (107142079 - 107187462 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for EFNB2: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing EFNB2
    DNA2.0 Custom Variant and Variant Library Synthesis for EFNB2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 600527    OMIM disorders: --

    1 disease for EFNB2:    
    About MalaCards
    craniofrontonasal syndrome

    1 disease from the University of Copenhagen DISEASES database for EFNB2:
    Craniofrontonasal syndrome

    Find genes that share disorders with EFNB2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for EFNB2 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neovascularization 50.3 7 15851594 (4), 17133777 (2), 20233847 (1)
    endometrial carcinoma 16.5 3 11295082 (3)
    tumors 15.8 7 16951162 (3), 10984508 (1), 9533549 (1), 20233847 (1)
    thyroid cancer 14.1 1 16360397 (1)
    hepatocellular carcinoma 9.1 2 16951162 (2)
    colorectal cancer 7.06 3 15083195 (2)
    ischemia 0 2 17234965 (1), 15851594 (1)
    colon cancer 0 9 15083195 (3), 16596216 (1)
    metastasis 0 4 17611172 (1), 9533549 (1)
    melanoma 0 6 9533549 (6)

    Genetic Association Database (GAD): EFNB2
    Human Genome Epidemiology (HuGE) Navigator: EFNB2 (2 documents)

    Export disorders for EFNB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for EFNB2 gene, integrated from 10 sources (see all 172):
    (articles sorted by number of sources associating them with EFNB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association analysis of the ephrin-B2 gene in African-Americans with end-stage renal disease. (PubMed id 18580054)1, 4, 9 Hicks P.J....Freedman B.I. (Am. J. Nephrol. 2008)
    2. Overexpression of Lerk-5/Eplg5 messenger RNA: a novel marker for increased tumorigenicity and metastatic potential in human malignant melanomas. (PubMed id 9533549)1, 2, 9 Vogt T.... McClelland M. (Clin. Cancer Res. 1998)
    3. Structural characterization of the EphA4-Ephrin-B2 complex reveals new features enabling Eph-ephrin binding promiscuity. (PubMed id 19875447)1, 2, 9 Qin H.... Song J. (J. Biol. Chem. 2010)
    4. Structural basis of Nipah and Hendra virus attachment to their cell- surface receptor ephrin-B2. (PubMed id 18488039)1, 2, 9 Bowden T.A....Stuart D.I. (Nat. Struct. Mol. Biol. 2008)
    5. Is the EFNB2 locus associated with schizophrenia? Single nucleotide polymorphisms and haplotypes analysis. (PubMed id 20483485)1, 4 Zhang R....Ma J. (Psychiatry Res 2010)
    6. Structural and biophysical characterization of the EphB4*ephrinB2 protein-protein interaction and receptor specificity. (PubMed id 16867992)1, 2 Chrencik J.E.... Kuhn P. (J. Biol. Chem. 2006)
    7. EphrinB2 is the entry receptor for Nipah virus, an emergent deadly paramyxovirus. (PubMed id 16007075)1, 2 Negrete O.A.... Lee B. (Nature 2005)
    8. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (Nature 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Forward EphB4 signaling in endothelial cells controls cellular repulsion and segregation from ephrinB2 positive cells. (PubMed id 12734395)1, 2 Fueller T.... Augustin H.G. (J. Cell Sci. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 1948 HGNC: 3227 AceView: EFNB2 Ensembl:ENSG00000125266 euGenes: HUgn1948
    ECgene: EFNB2 Kegg: 1948 H-InvDB: EFNB2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for EFNB2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EFNB2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for EFNB2 gene:
    Search GeneIP for patents involving EFNB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     Browse Kits and Assays available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of EFNB2
     
     EMD Millipore genomic analysis products

      
     Antibodies for EFNB2 (Ephrin-B2)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for EFNB2 (Ephrin-B2)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for EFNB2   OriGene RNAi products in human, mouse, rat for EFNB2  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for EFNB2  
     OriGene MassSpec for EFNB2   OriGene clones in human, mouse for EFNB2  
     OriGene qSTAR qPCR primer pairs in human, mouse for EFNB2   OriGene Purified Protein for EFNB2  
     OriGene ORF clones in mouse, rat for EFNB2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for EFNB2   OriGene Custom Protein Services for EFNB2  

     
     
     Block miRNA regulation of human, mouse, rat EFNB2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing EFNB2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EFNB2 Predesigned siRNA for gene silencing in human, mouse, rat EFNB2
     QuantiFast Probe-based Assays in human, mouse, rat EFNB2 QuantiTect SYBR Green Assays in human, mouse, rat EFNB2
     PCR Arrays including human, mouse, rat EFNB2 Search Chromatin IP Primers for EFNB2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EFNB2  GeneGlobe Interaction Network for EFNB2
     Regulatory tfbs in EFNB2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for EFNB2 GenScript cDNA clones with any tag delivered in your preferred vector for EFNB2
     GenScript Custom Assay Services for EFNB2 GenScript Custom overexpressing Cell Line Services for EFNB2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for EFNB2 

     Search Tocris compounds for EFNB2
     Proteins for EFNB2
     Cell Lysates for EFNB2
     cDNA Clones for EFNB2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     EFNB2 antibodies
     EFNB2 proteins
     EFNB2 lysates
     Antibodies for EFNB2
     See all of Abcam's Antibodies, Kits and Proteins for EFNB2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for EFNB2
     Proteins for EFNB2
     Antibodies for EFNB2
     ELISAs for EFNB2
     CLIAs for EFNB2



     Browse ESI BIO Cell Lines and PureStem Progenitors for EFNB2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EFNB2
     SwitchGear 3'UTR luciferase reporter plasmids for EFNB2
     SwitchGear Promoter luciferase reporter plasmids for EFNB2
     ThermoFisher Antibodies for EFNB2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EFNB2
     Browse compounds at ApexBio
     Search Addgene for plasmids for EFNB2
      Search eBioscience for proteins for EFNB2
      Search eBioscience for elisas for EFNB2
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for EFNB2
     antibodies-online antibodies for EFNB2 (59 products)
     antibodies-online kits for EFNB2 (8 products)
     antibodies-online peptides for EFNB2
     antibodies-online proteins for EFNB2 (17 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      EFNB2 gene at Home site.
    Version: 3.12.252 27 Nov 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4