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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EFNB2 Gene

protein-coding   GIFtS: 66
GCID: GC13M107142

ephrin-B2


(Previous symbol: EPLG5)
 Explore 37 diseases affiliated with
EFNB2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for EFNB2    

Aliases
for EFNB2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ephrin-B21     HTK Ligand2 3
EPLG51 2 3 5     MGC1262261
HTKL1 2 3 5     MGC1262271
LERK51 2 3 5     MGC1262281
Htk-L1 2     Ligand Of Eph-Related Kinase 52
EPH-Related Receptor Tyrosine Kinase Ligand 52 3     HTK-L3
LERK-52 3     

External Ids:    HGNC: 32271   Entrez Gene: 19482   Ensembl: ENSG000001252667   OMIM: 6005275   UniProtKB: P527993   

Export aliases for EFNB2 gene to outside databases

Previous GC identifers: GC13M105503 GC13M101530 GC13M105980 GC13M104840 GC13M105940 GC13M087733


Summaries
for EFNB2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for EFNB2:
This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest
subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially
in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided
into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the
ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the
EPHB4 and EPHA3 receptors. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: EFNB2_HUMAN, P52799
Function: Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial
for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph
receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The
signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway
downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including
EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through
regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and
segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting
axons

Gene Wiki entry for EFNB2


Genomic Views
for EFNB2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.1  NT_009952.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EFNB2 gene promoter:
         Oct-B1   NF-1   NF-1/L   oct-B2   oct-B3   IRF-1   POU2F2   GATA-1   IRF-2   POU2F1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: EFNB2 promoter sequence
   Search SABiosciences Chromatin IP Primers for EFNB2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EFNB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q33   Ensembl cytogenetic band:  13q33.3   HGNC cytogenetic band: 13q33

EFNB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EFNB2 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M107142:  view genomic region     (about GC identifiers)

Start:
 107,142,093 bp from pter      End:
 107,187,462 bp from pter
Size:
 45,370 bases      Orientation:
 minus strand

Proteins
for EFNB2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: EFNB2_HUMAN, P52799 (See protein sequence)
Recommended Name: Ephrin-B2 precursor  
Size: 333 amino acids; 36923 Da
Subunit: Interacts with PDZRN3 (By similarity). Binds to the receptor tyrosine kinases EPHA4, EPHB4 and EPHA3. Binds to
Hendra virus and Nipah virus G protein
Subcellular location: Membrane; Single-pass type I membrane protein
6 PDB 3D structures from and Proteopedia for EFNB2:
2HLE (3D)        2I85 (3D)        2VSK (3D)        2VSM (3D)        2WO2 (3D)        3GXU (3D)    
Secondary accessions: Q5JV56

Explore the universe of human proteins at neXtProt for EFNB2: NX_P52799

Post-translational modifications:

  • Inducible phosphorylation of tyrosine residues in the cytoplasmic domain (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P52799

    • EFNB2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004084.1  
    ENSEMBL proteins: 
     ENSP00000245323  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: EFNB2
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    Novus Biologicals EFNB2 Proteins
    Novus Biologicals EFNB2 Lysate
    Sino Biological Recombinant Protein for EFNB2
    ProSpec Recombinant Protein for EFNB2
    Uscn Proteins for EFNB2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS8660976
    GO:0005887integral to plasma membrane TAS8660976


    EFNB2 for ontologies           About GeneDecksing



    EFNB2 Antibody Products: 
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    ThermoFisher Antibody for EFNB2

    Assay Products for EFNB2: 
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    Uscn ELISAs and CLIAs for EFNB2

    Protein Domains /
    Families
    for EFNB2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    EFNB2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001799 Ephrin
     IPR008972 Cupredoxin
     IPR019765 Ephrin_CS

    Graphical View of Domain Structure for InterPro Entry P52799

    ProtoNet protein and cluster: P52799

    1 Blocks protein family: IPB001799 Ephrin signature

    UniProtKB/Swiss-Prot: EFNB2_HUMAN, P52799
    Similarity: Belongs to the ephrin family
    Similarity: Contains 1 ephrin RBD (ephrin receptor-binding) domain


    Function
    for EFNB2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: EFNB2_HUMAN, P52799
    Function: Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial
    for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph
    receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The
    signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway
    downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including
    EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through
    regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and
    segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting
    axons

         Genatlas biochemistry entry for EFNB2:
    ephrin B-2,eph-related receptor tyrosine kinase,class B,ligand,high affinity,involved in short-range contact-mediated
    axonal guidance,also involved in angiogenesis by marking arterial but not venous endothelial cells

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EFNB2
    8/122 QIAGEN miScript miRNA Assays for microRNAs that regulate EFNB2 (see all 122):
    hsa-miR-3152-3p hsa-miR-520e hsa-miR-300 hsa-miR-188-5p hsa-miR-15a hsa-miR-106a hsa-miR-3653 hsa-miR-219-5p
    SwitchGear 3'UTR luciferase reporter plasmid: EFNB2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EFNB2 (see all 7)
    OriGene shRNA RFP: EFNB2
    OriGene siRNA: EFNB2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EFNB2

    Gene Editing
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    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: EFNB2 (NM_004093)
    Sino Biological Human cDNA Clone for EFNB2
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EFNB2 

    Cell Line
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    Search LifeMap BioReagents cell lines for EFNB2

    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding ----
    GO:0005515protein binding ----
    GO:0046875ephrin receptor binding IPI16867992


    EFNB2 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for EFNB2:
     Decreased TP53 protein express  Decreased viability with pacli  Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-outs for EFNB2: Efnb2tm5Kln Efnb2tm1.1Henk
         15/23 MGI mutant phenotypes (inferred from 19 alleles) (MGI details for Efnb2) (see all 23):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size  hearing/vestibular/ear  hematopoietic system 
     homeostasis/metabolism  immune system  integument  mortality/aging  muscle 

    EFNB2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for EFNB2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell adhesion_Ephrins signaling
    		Cell adhesion_Ephrins signaling1.00
    		EPHB forward signaling0.30
    		Cell adhesion Ephrins signaling1.00
    2Cytoskeleton remodeling_Reverse signaling by ephrin B
    		Cytoskeleton remodeling_Reverse signaling by ephrin B1.00
    		Cytoskeleton remodeling Reverse signaling by ephrin B0.94
    3EphB-EphrinB Signaling
    		EphB-EphrinB Signaling1.00
    		Ephrin-Eph Signaling0.58
    4Tyrosine Kinases / Adaptors
    		Tyrosine Kinases / Adaptors1.00
    5Angiogenesis
    		Angiogenesis1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for EFNB2
        Cytoskeleton remodeling Reverse signaling by ephrin B
    Cell adhesion Ephrins signaling

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for EFNB2
        EphB-EphrinB Signaling
    Ephrin-Eph Signaling

    2 Cell Signaling Technology (CST) Pathways for EFNB2
        Angiogenesis
    Tyrosine Kinases / Adaptors

    2 GeneGo (Thomson Reuters) Pathways for EFNB2
        Cytoskeleton remodeling Reverse signaling by ephrin B
    Cell adhesion Ephrins signaling

    3 BioSystems Pathways for EFNB2 
        EPHB forward signaling
    Ephrin B reverse signaling
    EphrinB-EPHB pathway


    1         Kegg Pathway  (Kegg details for EFNB2):
        Axon guidance


    EFNB2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for EFNB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/41 Interacting proteins for EFNB2 (P527992, 3 ENSP000002453234) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCK2O436392, 3, ENSP000002331544MINT-8036407 MINT-8038295 MINT-8027798 MINT-8027813 MINT-8038280 MINT-8027783 MINT-8038342 I2D: score=2 STRING: ENSP00000233154
    EPHB1P547623, ENSP000003810974I2D: score=2 STRING: ENSP00000381097
    DLG4P783523, ENSP000002938134I2D: score=1 STRING: ENSP00000293813
    EPHB6O151973, ENSP000003766844I2D: score=1 STRING: ENSP00000376684
    GRM5P415943, ENSP000003061384I2D: score=1 STRING: ENSP00000306138
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001945lymph vessel development IEA--
    GO:0002042cell migration involved in sprouting angiogenesis IDA12734395
    GO:0007155cell adhesion IDA12734395
    GO:0007219Notch signaling pathway ----
    GO:0007267cell-cell signaling TAS8559144


    EFNB2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for EFNB2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    EFNB2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for EFNB2

    1 DrugBank Compound for EFNB2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Alpha-D-Mannose-- 3458-28-4target--10592235

    3 Novoseek chemical compound relationships for EFNB2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 56 6 19728339 (1), 9259557 (1), 16413489 (1), 10221518 (1) (see all 5)
    vegf 26.6 6 16951162 (3), 15603710 (2), 15471957 (1)
    retinoic acid 0 4 15318809 (1)

    Search CenterWatch for drugs/clinical trials and news about EFNB2 

    Transcripts
    for EFNB2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for EFNB2 gene: 
    NM_004093.3  

    Unigene Cluster for EFNB2:

    Ephrin-B2
    Hs.149239  [show with all ESTs]
    Unigene Representative Sequence: NM_004093
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000245323(uc001vqi.3)

    miRNA
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    hsa-miR-3152-3p hsa-miR-520e hsa-miR-300 hsa-miR-188-5p hsa-miR-15a hsa-miR-106a hsa-miR-3653 hsa-miR-219-5p
    SwitchGear 3'UTR luciferase reporter plasmid: EFNB2 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    BC069342.1 BC074856.2 BC074857.2 BC105955.1 BC105956.1 BC105957.1 L38734.1 U16797.1 
    U81262.1 

    6 DOTS entries:

    DT.446863  DT.120772470  DT.100746826  DT.40111143  DT.100783872  DT.95275439 

    24/200 AceView cDNA sequences (see all 200):

    AU280529 CR609389 NM_004093 BC074856 BQ029549 AA938595 AI335696 AW193320 
    AW192736 AA255466 BM725282 AI827241 AA662640 AA292568 AI335686 AI248016 
    CN483205 BC074857 BU152920 AA918115 BQ433342 AI278926 CA416546 BU621951 

    GeneLoc Exon Structure


    Expression
    for EFNB2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EFNB2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AATATTTATT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    EFNB2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    7 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EndotheliumArteriesArterial endothelial cellsEndothelium
    HeartDorsal AortaArterial Endothelial CellsEndothelium
    Lateral Plate MesodermPaired Dorsal AortaArterial endothelial cellsEndothelium
    LungPulmonary Capillary PlexusArterial Endothelial CellsEndothelium
    Lateral Plate MesodermEmbryonic Capillary PlexusAngioblastsEndothelium
    LungPulmonary Capillary PlexusAngioblastsEndothelium
    EyeInner Nuclear LayernGnG Amacrine CellsAmacrine, Retina
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 10/15 LifeMap Cells (see all 15) 
    NameCategory
    PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)Endothelium
    PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)Endothelium
    PureStem™ progenitor T42 (Embryonic Progenitor Cell)
    PureStem™ progenitor E69 (Embryonic Progenitor Cell)
    PureStem™ progenitor SK17 (Embryonic Progenitor Cell)
    PureStem™ progenitor T36 (Embryonic Progenitor Cell)
    PureStem™ progenitor U31 (Embryonic Progenitor Cell)
    Line H9 (WA09) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass

    See EFNB2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EFNB2

    SOURCE GeneReport for Unigene cluster: Hs.149239

    UniProtKB/Swiss-Prot: EFNB2_HUMAN, P52799
    Tissue specificity: Lung and kidney

        SABiosciences Expression via Pathway-Focused PCR Arrays including EFNB2: 
              Terminal Differentiation Markers in human mouse rat
              Angiogenesis in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EFNB2

    Orthologs
    for EFNB2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for EFNB2 gene from 6/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves EFNB21 ephrin-B2 83.33(n)
    90(a)    		   395625  NM_204824.1  NP_990155.1 
    lizard
    (Anolis carolinensis)    		 Reptilia EFNB26
    		 --
    		 89(a)
    		 1 ↔ 1
    		 3(103539783-103575312)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC688902 hypothetical protein MGC68890 77.33(n)    BC057724.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii AF375226.12   -- 76.23(n)   114402  AF375226.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Ephrin6
    		 Ephrin
    		 10(a)
    		 1 → many
    		 4(592381-600748)
    worm
    (Caenorhabditis elegans)    		 Secernentea efn-26
    efn-36
    (see all 3)    		 Eph(F)riN family member (efn-3)
    (see all 3)    		 30(a)
    28(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 IV(10576330-10578266)
    X(13475842-13477388)


    ENSEMBL Gene Tree for EFNB2 (if available)
    TreeFam Gene Tree for EFNB2 (if available) 

    Paralogs
    for EFNB2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for EFNB2 gene
    EFNB12  EFNB32  
    2 SIMAP similar genes for EFNB2 using alignment to 2 protein entries:     EFNB2_HUMAN (see all proteins):
    EFNB1    EFNB3

    EFNB2 for paralogs           About GeneDecksing



    Genomic Variants
    for EFNB2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/795 NCBI SNPs in EFNB2 are shown (see all 795)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 13 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1877708221,2
    		--107141676(+) TAGACC/TGCTGC 1 -- ds50010--------
    rs73293571,2
    		C,F,A,H,--107141705(+) AGATCG/AATCTG 1 -- ds500117Minor allele frequency- A:0.43NA NS EA WA CSA 929
    rs1143948221,2
    		F,--107141731(+) TAAGAG/ATACAT 1 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1485629751,2
    		--107141749(+) TTTTTC/TCTGAG 1 -- ds50010--------
    rs341340521,2
    		--107141918(+) AATTAA/GTATTT 1 -- ds50010--------
    rs1856857681,2
    		--107141942(+) ATCCCA/GATTTG 1 -- ds50010--------
    rs1877751031,2
    		--107141945(+) CCGATG/TTGAAA 1 -- ds50010--------
    rs1455183421,2
    		--107142012(+) AAATAC/GAGTAA 1 -- ds50010--------
    rs1919261481,2
    		--107142054(+) GAAAGA/GAAAAT 1 -- ds50010--------
    rs1843935201,2
    		--107142168(+) CTTCAC/TGGATT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for EFNB2 (107142093 - 107187462 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for EFNB2: --

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    Disorders / Diseases
    for EFNB2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    EFNB2 for disorders           About GeneDecksing

    OMIM gene information: 600527    OMIM disorders: --

    20/37 diseases for EFNB2 (see all 37):    About MalaCards
    vacterl association    venous malformations    leukemia/lymphoma    craniofrontonasal syndrome
    squamous cell carcinoma of the head and neck    leukemia/lymphoma, t-cell    squamous cell carcinoma    kaposi's sarcoma
    endometrial carcinoma    hepatocellular carcinoma    thyroid cancer    carcinoma
    colorectal cancer    crohn's disease    nephropathy    endometrial cancer
    rhabdomyosarcoma    thyroiditis    polyposis    sarcoma

    10/11 Novoseek disease relationships for EFNB2 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neovascularization 50.3 7 15851594 (4), 17133777 (2), 20233847 (1)
    endometrial carcinoma 16.5 3 11295082 (3)
    tumors 15.8 7 16951162 (3), 10984508 (1), 9533549 (1), 20233847 (1)
    thyroid cancer 14.1 1 16360397 (1)
    hepatocellular carcinoma 9.1 2 16951162 (2)
    colorectal cancer 7.06 3 15083195 (2)
    ischemia 0 2 17234965 (1), 15851594 (1)
    colon cancer 0 9 15083195 (3), 16596216 (1)
    metastasis 0 4 17611172 (1), 9533549 (1)
    melanoma 0 6 9533549 (6)

    Human Genome Epidemiology (HuGE) Navigator: EFNB2 (2 documents)

    Export disorders for EFNB2 gene to outside databases

    Publications
    for EFNB2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EFNB2 gene, integrated from 9 sources (see all 166):
    (articles sorted by number of sources associating them with EFNB2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Overexpression of Lerk-5/Eplg5 messenger RNA: a novel marker for increased tumorigenicity and metastatic potential in human malignant melanomas. (PubMed id 9533549)1, 2, 9 Vogt T.... McClelland M. (1998)
    2. Structural characterization of the EphA4-Ephrin-B2 co mplex reveals new features enabling Eph-ephrin binding promiscuity. (PubMed id 19875447)1, 2, 9 Qin H....Song J. (2010)
    3. Structural basis of Nipah and Hendra virus attachment to their cell-surface receptor ephrin-B2. (PubMed id 18488039)1, 2, 9 Bowden T.A....Stuart D.I. (2008)
    4. Structural and biophysical characterization of the EphB4*ephrinB2 protein-protein interaction and receptor specificity. (PubMed id 16867992)1, 2 Chrencik J.E....Kuhn P. (2006)
    5. EphrinB2 is the entry receptor for Nipah virus, an emergent deadly paramyxovirus. (PubMed id 16007075)1, 2 Negrete O.A....Lee B. (2005)
    6. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Forward EphB4 signaling in endothelial cells controls cellular repulsion and segregation from ephrinB2 positive cells. (PubMed id 12734395)1, 2 Fuller T....Augustin H.G. (2003)
    9. Isolation of LERK-5: a ligand of the eph-related receptor tyrosine kinases. (PubMed id 8559144)1, 2 Cerretti D.P.... Fletcher R.A. (1995)
    10. Molecular cloning of a ligand for the EPH-related receptor protein- tyrosine kinase Htk. (PubMed id 7534404)1, 2 Bennett B.D.... Matthews W. (1995)

    External Searches for EFNB2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
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    Genome Databases showing EFNB2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1948 HGNC: 3227 AceView: EFNB2 Ensembl:ENSG00000125266 euGenes: HUgn1948
    ECgene: EFNB2 Kegg: 1948 H-InvDB: EFNB2

    Other Databases showing EFNB2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing EFNB2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for EFNB2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EFNB2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for EFNB2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for EFNB2 gene:
    Search GeneIP for patents involving EFNB2

    GeneCards and IP:
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