Aliases for EFNB1 Gene
External Ids for EFNB1 Gene
Previous HGNC Symbols for EFNB1 Gene
Previous GeneCards Identifiers for EFNB1 Gene
The protein encoded by this gene is a type I membrane protein and a ligand of Eph-related receptor tyrosine kinases. It may play a role in cell adhesion and function in the development or maintenance of the nervous system. [provided by RefSeq, Jul 2008]
GeneCards Summary for EFNB1 Gene
EFNB1 (Ephrin B1) is a Protein Coding gene. Diseases associated with EFNB1 include craniofrontonasal dysplasia and craniosynostosis. Among its related pathways are Axon guidance and Angiogenesis (CST). GO annotations related to this gene include ephrin receptor binding. An important paralog of this gene is EFNB2.
UniProtKB/Swiss-Prot for EFNB1 Gene
Binds to the receptor tyrosine kinases EPHB1 and EPHA1. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity).
Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to the receptor tyrosine kinases EPHB3 (preferred), EPHB1 and EPHA1. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity).