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Aliases for EFNA5 Gene

Aliases for EFNA5 Gene

  • Ephrin-A5 2 3
  • LERK-7 3 4
  • EPLG7 3 4
  • LERK7 3 4
  • AL-1 3 4
  • Eph-Related Receptor Tyrosine Kinase Ligand 7 3
  • EPH-Related Receptor Tyrosine Kinase Ligand 7 4
  • GLC1M 3
  • EFL5 3
  • RAGS 3
  • AF1 3

External Ids for EFNA5 Gene

Previous HGNC Symbols for EFNA5 Gene

  • EPLG7

Previous GeneCards Identifiers for EFNA5 Gene

  • GC05M106471
  • GC05M107162
  • GC05M106747
  • GC05M106792
  • GC05M106744
  • GC05M101885
  • GC05M106712

Summaries for EFNA5 Gene

Entrez Gene Summary for EFNA5 Gene

  • Ephrin-A5, a member of the ephrin gene family, prevents axon bundling in cocultures of cortical neurons with astrocytes, a model of late stage nervous system development and differentiation. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. [provided by RefSeq, Jul 2008]

GeneCards Summary for EFNA5 Gene

EFNA5 (Ephrin-A5) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and Ras signaling pathway. GO annotations related to this gene include ephrin receptor binding and chemorepellent activity. An important paralog of this gene is EFNA3.

UniProtKB/Swiss-Prot for EFNA5 Gene

  • Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion.

Gene Wiki entry for EFNA5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EFNA5 Gene

Genomics for EFNA5 Gene

Regulatory Elements for EFNA5 Gene

Genomic Location for EFNA5 Gene

Start:
107,376,889 bp from pter
End:
107,670,895 bp from pter
Size:
294,007 bases
Orientation:
Minus strand

Genomic View for EFNA5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EFNA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EFNA5 Gene

Proteins for EFNA5 Gene

  • Protein details for EFNA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52803-EFNA5_HUMAN
    Recommended name:
    Ephrin-A5
    Protein Accession:
    P52803
    Secondary Accessions:

    Protein attributes for EFNA5 Gene

    Size:
    228 amino acids
    Molecular mass:
    26297 Da
    Quaternary structure:
    • Binds to EPHB2. Interacts with EPHA8; activates EPHA8 (By similarity). Binds to the receptor tyrosine kinases EPHA2, EPHA3 and EPHB1. Forms a ternary EFNA5-EPHA3-ADAM10 complex mediating EFNA5 extracellular domain shedding by ADAM10 which regulates the EFNA5-EPHA3 complex internalization and function.

    Three dimensional structures from OCA and Proteopedia for EFNA5 Gene

neXtProt entry for EFNA5 Gene

Proteomics data for EFNA5 Gene at MOPED

Post-translational modifications for EFNA5 Gene

  • Glycosylation at Asn37
  • Modification sites at PhosphoSitePlus

Other Protein References for EFNA5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EFNA5 Gene

Domains for EFNA5 Gene

Gene Families for EFNA5 Gene

HGNC:

Protein Domains for EFNA5 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for EFNA5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P52803

UniProtKB/Swiss-Prot:

EFNA5_HUMAN :
  • P52803
Domain:
  • Contains 1 ephrin RBD (ephrin receptor-binding) domain.
Family:
  • Belongs to the ephrin family.
genes like me logo Genes that share domains with EFNA5: view

Function for EFNA5 Gene

Molecular function for EFNA5 Gene

GENATLAS Biochemistry: ephrin A-5,eph-related receptor tyrosine kinase,class A,ligand,high affinity,involved in short-range contact-mediated axonal guidance
UniProtKB/Swiss-Prot Function: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion.

Gene Ontology (GO) - Molecular Function for EFNA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0045499 chemorepellent activity IEA --
GO:0046875 ephrin receptor binding IPI 11870224
genes like me logo Genes that share ontologies with EFNA5: view
genes like me logo Genes that share phenotypes with EFNA5: view

Animal Models for EFNA5 Gene

MGI Knock Outs for EFNA5:

miRNA for EFNA5 Gene

miRTarBase miRNAs that target EFNA5

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for EFNA5 Gene

Localization for EFNA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EFNA5 Gene

Cell membrane; Lipid-anchor, GPI-anchor. Membrane, caveola; Lipid-anchor, GPI-anchor. Note=Compartmentalized in discrete caveolae-like membrane microdomains.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EFNA5 Gene COMPARTMENTS Subcellular localization image for EFNA5 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1
endosome 1
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for EFNA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
GO:0005901 caveola IEA --
GO:0016020 membrane --
GO:0031362 anchored component of external side of plasma membrane IDA 11870224
genes like me logo Genes that share ontologies with EFNA5: view

Pathways for EFNA5 Gene

genes like me logo Genes that share pathways with EFNA5: view

Gene Ontology (GO) - Biological Process for EFNA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 NOT apoptotic process IDA 11870224
GO:0007399 nervous system development TAS 9245480
GO:0007411 axon guidance TAS --
GO:0022407 regulation of cell-cell adhesion IDA 11870224
GO:0031290 retinal ganglion cell axon guidance IEA --
genes like me logo Genes that share ontologies with EFNA5: view

Compounds for EFNA5 Gene

(8) Novoseek inferred chemical compound relationships for EFNA5 Gene

Compound -log(P) Hits PubMed IDs
4-hydroxytamoxifen 63.9 2
tyrosine 57.1 11
estrogen 49.2 14
retinoic acid 29 5
tamoxifen 25.5 1
genes like me logo Genes that share compounds with EFNA5: view

Transcripts for EFNA5 Gene

mRNA/cDNA for EFNA5 Gene

(10) Selected AceView cDNA sequences:
(4) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EFNA5 Gene

Ephrin-A5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EFNA5 Gene

No ASD Table

Relevant External Links for EFNA5 Gene

GeneLoc Exon Structure for
EFNA5
ECgene alternative splicing isoforms for
EFNA5

Expression for EFNA5 Gene

mRNA expression in normal human tissues for EFNA5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EFNA5 Gene

SOURCE GeneReport for Unigene cluster for EFNA5 Gene Hs.288741

genes like me logo Genes that share expressions with EFNA5: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EFNA5 Gene

Orthologs for EFNA5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for EFNA5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EFNA5 35
  • 99.85 (n)
  • 100 (a)
EFNA5 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EFNA5 35
  • 92.84 (n)
  • 98.68 (a)
EFNA5 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EFNA5 36
  • 96 (a)
OneToOne
LOC608458 35
  • 95.75 (n)
  • 99.06 (a)
mouse
(Mus musculus)
Mammalia Efna5 35
  • 96.64 (n)
  • 99.12 (a)
Efna5 16
Efna5 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EFNA5 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EFNA5 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Efna5 35
  • 96.35 (n)
  • 98.68 (a)
chicken
(Gallus gallus)
Aves EFNA5 35
  • 87.79 (n)
  • 91.55 (a)
EFNA5 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EFNA5 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia efna5 35
  • 84.43 (n)
  • 90.09 (a)
Str.16764 35
zebrafish
(Danio rerio)
Actinopterygii efna5a 36
  • 60 (a)
OneToMany
efna5b 35
  • 74.24 (n)
  • 79.71 (a)
efna5b 36
  • 78 (a)
OneToMany
Species with no ortholog for EFNA5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EFNA5 Gene

ENSEMBL:
Gene Tree for EFNA5 (if available)
TreeFam:
Gene Tree for EFNA5 (if available)

Paralogs for EFNA5 Gene

Paralogs for EFNA5 Gene

Selected SIMAP similar genes for EFNA5 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with EFNA5: view

Variants for EFNA5 Gene

Sequence variations from dbSNP and Humsavar for EFNA5 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs2283 -- 107,437,922(-) CTTGG(C/T)TAGGC intron-variant
rs2859 -- 107,376,998(+) TTTTT(G/T)TTACA utr-variant-3-prime
rs14038 -- 107,378,789(-) TTTTC(C/T)TAGCA utr-variant-3-prime
rs25740 -- 107,474,711(+) GCTAA(C/T)ACAGG intron-variant
rs25953 -- 107,454,017(+) TATTA(A/T)CCCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EFNA5 Gene

Variant ID Type Subtype PubMed ID
esv34018 CNV Loss 18971310
nsv527761 CNV Loss 19592680
esv268824 CNV Insertion 20981092
esv272484 CNV Insertion 20981092
nsv820161 CNV Loss 19587683
esv2666449 CNV Deletion 23128226
esv2730573 CNV Deletion 23290073
esv1464984 CNV Deletion 17803354
nsv462379 CNV Gain 19166990
nsv471037 CNV Gain 18288195
nsv328216 CNV Insertion 16902084
esv2730574 CNV Deletion 23290073
esv2036103 CNV Deletion 18987734
nsv328213 CNV Loss 16902084
esv2633190 CNV Deletion 19546169
esv2730575 CNV Deletion 23290073
nsv819976 CNV Gain 19587683
esv2730576 CNV Deletion 23290073
esv2671807 CNV Deletion 23128226
nsv4949 CNV Insertion 18451855

Relevant External Links for EFNA5 Gene

HapMap Linkage Disequilibrium report
EFNA5
Human Gene Mutation Database (HGMD)
EFNA5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EFNA5 Gene

Disorders for EFNA5 Gene

(1) University of Copenhagen DISEASES for EFNA5 Gene

(8) Novoseek inferred disease relationships for EFNA5 Gene

Disease -log(P) Hits PubMed IDs
ebv infections 15.3 1
breast cancer 6.57 4
retinoblastoma 1.22 1
necrosis 0 1
osteosarcoma 0 1

Relevant External Links for EFNA5

Genetic Association Database (GAD)
EFNA5
Human Genome Epidemiology (HuGE) Navigator
EFNA5
genes like me logo Genes that share disorders with EFNA5: view

No data available for UniProtKB/Swiss-Prot for EFNA5 Gene

Publications for EFNA5 Gene

  1. Compartmentalized signaling by GPI-anchored ephrin-A5 requires the Fyn tyrosine kinase to regulate cellular adhesion. (PMID: 10601038) Davy A. … Robbins S.M. (Genes Dev. 1999) 3 4 23
  2. Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3- expressing 293T and melanoma cells by CrkII and Rho-mediated signalling. (PMID: 11870224) Lawrenson I.D. … Lackmann M. (J. Cell Sci. 2002) 3 4 23
  3. Crystal structure of the human ephrin-A5 ectodomain. (PMID: 17400922) Nikolov D.B. … Himanen J.P. (Protein Sci. 2007) 3 4 23
  4. LERK-7: a ligand of the Eph-related kinases is developmentally regulated in the brain. (PMID: 9245480) Kozlosky C.J. … Carpenter M.K. (Cytokine 1997) 2 3 4
  5. A subset of signal transduction pathways is required for hippocampal growth cone collapse induced by ephrin-A5. (PMID: 18563700) Yue X. … Zhou R. (Dev Neurobiol 2008) 3 23

Products for EFNA5 Gene

Sources for EFNA5 Gene

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