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Aliases for EFNA5 Gene

Aliases for EFNA5 Gene

  • Ephrin A5 2 3
  • Ephrin-A5 2 5
  • LERK-7 3 4
  • EPLG7 3 4
  • LERK7 3 4
  • AL-1 3 4
  • Eph-Related Receptor Tyrosine Kinase Ligand 7 3
  • EPH-Related Receptor Tyrosine Kinase Ligand 7 4
  • GLC1M 3
  • EFL5 3
  • RAGS 3
  • AF1 3

External Ids for EFNA5 Gene

Previous HGNC Symbols for EFNA5 Gene

  • EPLG7

Previous GeneCards Identifiers for EFNA5 Gene

  • GC05M106471
  • GC05M107162
  • GC05M106747
  • GC05M106792
  • GC05M106744
  • GC05M101885
  • GC05M106712

Summaries for EFNA5 Gene

Entrez Gene Summary for EFNA5 Gene

  • Ephrin-A5, a member of the ephrin gene family, prevents axon bundling in cocultures of cortical neurons with astrocytes, a model of late stage nervous system development and differentiation. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. [provided by RefSeq, Jul 2008]

GeneCards Summary for EFNA5 Gene

EFNA5 (Ephrin A5) is a Protein Coding gene. Diseases associated with EFNA5 include ebola hemorrhagic fever and artemis deficiency. Among its related pathways are Axon guidance and PI3K-Akt signaling pathway. GO annotations related to this gene include ephrin receptor binding and chemorepellent activity. An important paralog of this gene is EFNA3.

UniProtKB/Swiss-Prot for EFNA5 Gene

  • Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion.

Gene Wiki entry for EFNA5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EFNA5 Gene

Genomics for EFNA5 Gene

Regulatory Elements for EFNA5 Gene

Enhancers for EFNA5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around EFNA5 on UCSC Golden Path with GeneCards custom track

Promoters for EFNA5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EFNA5 on UCSC Golden Path with GeneCards custom track

Genomic Location for EFNA5 Gene

Chromosome:
5
Start:
107,376,889 bp from pter
End:
107,670,895 bp from pter
Size:
294,007 bases
Orientation:
Minus strand

Genomic View for EFNA5 Gene

Genes around EFNA5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EFNA5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EFNA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EFNA5 Gene

Proteins for EFNA5 Gene

  • Protein details for EFNA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52803-EFNA5_HUMAN
    Recommended name:
    Ephrin-A5
    Protein Accession:
    P52803

    Protein attributes for EFNA5 Gene

    Size:
    228 amino acids
    Molecular mass:
    26297 Da
    Quaternary structure:
    • Binds to EPHB2. Interacts with EPHA8; activates EPHA8 (By similarity). Binds to the receptor tyrosine kinases EPHA2, EPHA3 and EPHB1. Forms a ternary EFNA5-EPHA3-ADAM10 complex mediating EFNA5 extracellular domain shedding by ADAM10 which regulates the EFNA5-EPHA3 complex internalization and function.

    Three dimensional structures from OCA and Proteopedia for EFNA5 Gene

neXtProt entry for EFNA5 Gene

Proteomics data for EFNA5 Gene at MOPED

Post-translational modifications for EFNA5 Gene

  • Glycosylation at Asn 37
  • Modification sites at PhosphoSitePlus

Other Protein References for EFNA5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for EFNA5 Gene

Domains & Families for EFNA5 Gene

Gene Families for EFNA5 Gene

Protein Domains for EFNA5 Gene

Suggested Antigen Peptide Sequences for EFNA5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P52803

UniProtKB/Swiss-Prot:

EFNA5_HUMAN :
  • Contains 1 ephrin RBD (ephrin receptor-binding) domain.
  • Belongs to the ephrin family.
Domain:
  • Contains 1 ephrin RBD (ephrin receptor-binding) domain.
Family:
  • Belongs to the ephrin family.
genes like me logo Genes that share domains with EFNA5: view

Function for EFNA5 Gene

Molecular function for EFNA5 Gene

GENATLAS Biochemistry:
ephrin A-5,eph-related receptor tyrosine kinase,class A,ligand,high affinity,involved in short-range contact-mediated axonal guidance
UniProtKB/Swiss-Prot Function:
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion.

Gene Ontology (GO) - Molecular Function for EFNA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005169 neurotrophin TRKB receptor binding IEA,NAS 19036963
genes like me logo Genes that share ontologies with EFNA5: view
genes like me logo Genes that share phenotypes with EFNA5: view

Animal Models for EFNA5 Gene

MGI Knock Outs for EFNA5:

Animal Model Products

miRNA for EFNA5 Gene

miRTarBase miRNAs that target EFNA5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EFNA5 Gene

Localization for EFNA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EFNA5 Gene

Cell membrane; Lipid-anchor, GPI-anchor. Membrane, caveola; Lipid-anchor, GPI-anchor. Note=Compartmentalized in discrete caveolae-like membrane microdomains.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EFNA5 Gene COMPARTMENTS Subcellular localization image for EFNA5 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytoskeleton 1
endosome 1
lysosome 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for EFNA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane IEA,TAS --
GO:0005901 caveola IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with EFNA5: view

Pathways & Interactions for EFNA5 Gene

genes like me logo Genes that share pathways with EFNA5: view

SIGNOR curated interactions for EFNA5 Gene

Activates:

Gene Ontology (GO) - Biological Process for EFNA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 NOT apoptotic process IDA 11870224
GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity NAS 19036963
GO:0007411 axon guidance IEA,IBA --
GO:0022407 regulation of cell-cell adhesion IEA,IDA 11870224
GO:0031290 retinal ganglion cell axon guidance IEA --
genes like me logo Genes that share ontologies with EFNA5: view

Drugs & Compounds for EFNA5 Gene

(6) Drugs for EFNA5 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for EFNA5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with EFNA5: view

Transcripts for EFNA5 Gene

mRNA/cDNA for EFNA5 Gene

Unigene Clusters for EFNA5 Gene

Ephrin-A5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EFNA5 Gene

No ASD Table

Relevant External Links for EFNA5 Gene

GeneLoc Exon Structure for
EFNA5
ECgene alternative splicing isoforms for
EFNA5

Expression for EFNA5 Gene

mRNA expression in normal human tissues for EFNA5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for EFNA5 Gene

This gene is overexpressed in Ovary (25.9), Testis (23.9), and Frontal cortex (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EFNA5 Gene



SOURCE GeneReport for Unigene cluster for EFNA5 Gene Hs.288741

genes like me logo Genes that share expression patterns with EFNA5: view

Protein tissue co-expression partners for EFNA5 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EFNA5 Gene

Orthologs for EFNA5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for EFNA5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EFNA5 35
  • 92.84 (n)
  • 98.68 (a)
EFNA5 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC608458 35
  • 95.75 (n)
  • 99.06 (a)
EFNA5 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Efna5 35
  • 96.64 (n)
  • 99.12 (a)
Efna5 16
Efna5 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EFNA5 35
  • 99.85 (n)
  • 100 (a)
EFNA5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Efna5 35
  • 96.35 (n)
  • 98.68 (a)
oppossum
(Monodelphis domestica)
Mammalia EFNA5 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EFNA5 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves EFNA5 35
  • 87.79 (n)
  • 91.55 (a)
EFNA5 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EFNA5 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia efna5 35
  • 84.43 (n)
  • 90.09 (a)
Str.16764 35
zebrafish
(Danio rerio)
Actinopterygii efna5b 35
  • 74.24 (n)
  • 79.71 (a)
efna5a 36
  • 60 (a)
OneToMany
efna5b 36
  • 78 (a)
OneToMany
Species with no ortholog for EFNA5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EFNA5 Gene

ENSEMBL:
Gene Tree for EFNA5 (if available)
TreeFam:
Gene Tree for EFNA5 (if available)

Paralogs for EFNA5 Gene

Paralogs for EFNA5 Gene

(4) SIMAP similar genes for EFNA5 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with EFNA5: view

Variants for EFNA5 Gene

Sequence variations from dbSNP and Humsavar for EFNA5 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs469062 - 107,427,470(+) TAGTC(A/C)TTGAT reference, missense, utr-variant-5-prime
rs712546 -- 107,478,290(+) ATATT(C/G)TCAGC intron-variant
rs712555 -- 107,509,574(+) gatcc(A/G)cccgc intron-variant
rs712557 -- 107,516,716(+) CTAAA(C/T)CATGT intron-variant
rs712560 -- 107,544,107(+) CTTGC(A/G)AATCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EFNA5 Gene

Variant ID Type Subtype PubMed ID
esv34018 CNV Loss 18971310
nsv527761 CNV Loss 19592680
esv268824 CNV Insertion 20981092
esv272484 CNV Insertion 20981092
nsv820161 CNV Loss 19587683
esv2666449 CNV Deletion 23128226
esv2730573 CNV Deletion 23290073
esv1464984 CNV Deletion 17803354
nsv462379 CNV Gain 19166990
nsv471037 CNV Gain 18288195
nsv328216 CNV Insertion 16902084
esv2730574 CNV Deletion 23290073
esv2036103 CNV Deletion 18987734
nsv328213 CNV Loss 16902084
esv2633190 CNV Deletion 19546169
esv2730575 CNV Deletion 23290073
nsv819976 CNV Gain 19587683
esv2730576 CNV Deletion 23290073
esv2671807 CNV Deletion 23128226
nsv4949 CNV Insertion 18451855

Variation tolerance for EFNA5 Gene

Residual Variation Intolerance Score: 38.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.68; 14.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EFNA5 Gene

HapMap Linkage Disequilibrium report
EFNA5
Human Gene Mutation Database (HGMD)
EFNA5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EFNA5 Gene

Disorders for EFNA5 Gene

MalaCards: The human disease database

(3) MalaCards diseases for EFNA5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
ebola hemorrhagic fever
  • ebola virus disease
artemis deficiency
omenn syndrome
  • reticuloendotheliosis familial with eosinophilia
- elite association - COSMIC cancer census association via MalaCards
Search EFNA5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for EFNA5

Genetic Association Database (GAD)
EFNA5
Human Genome Epidemiology (HuGE) Navigator
EFNA5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EFNA5
genes like me logo Genes that share disorders with EFNA5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EFNA5 Gene

Publications for EFNA5 Gene

  1. LERK-7: a ligand of the Eph-related kinases is developmentally regulated in the brain. (PMID: 9245480) Kozlosky C.J. … Carpenter M.K. (Cytokine 1997) 2 3 4 67
  2. Down-regulation of ephrin-A5, a gene product of normal cartilage, in chondrosarcoma. (PMID: 19695673) Kalinski T. … Roessner A. (Hum. Pathol. 2009) 3 23
  3. A subset of signal transduction pathways is required for hippocampal growth cone collapse induced by ephrin-A5. (PMID: 18563700) Yue X. … Zhou R. (Dev Neurobiol 2008) 3 23
  4. Crystal structure of the human ephrin-A5 ectodomain. (PMID: 17400922) Nikolov D.B. … Himanen J.P. (Protein Sci. 2007) 3 23
  5. Three distinct molecular surfaces in ephrin-A5 are essential for a functional interaction with EphA3. (PMID: 15901737) Day B. … Lackmann M. (J. Biol. Chem. 2005) 3 23

Products for EFNA5 Gene

Sources for EFNA5 Gene

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