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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

EFNA5 Gene

protein-coding GIFtS: 63
GCID: GC05M106712

ephrin-A5

(Previous symbol: EPLG7)

Explore 29 diseases affiliated with
EFNA5 via

MalaCards

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Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ephrin-A5¹		AL-1² ³
EPLG7¹ ² ³		LERK-7² ³
LERK7¹ ² ³		EFL5²
AF1¹ ²		GLC1M²
EPH-Related Receptor Tyrosine Kinase Ligand 7² ³		RAGS²

External Ids:	HGNC: 3225¹	Entrez Gene: 1946²	Ensembl: ENSG00000184349⁷	OMIM: 601535⁵	UniProtKB: P52803³

Export aliases for EFNA5 gene to outside databases

Previous GC identifers: GC05M106471 GC05M107162 GC05M106747 GC05M106792 GC05M106744 GC05M101885

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for EFNA5:

Ephrin-A5, a member of the ephrin gene family, prevents axon bundling in cocultures of cortical neurons with

astrocytes, a model of late stage nervous system development and differentiation. The EPH and EPH-related receptors

comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating

developmental events, particularly in the nervous system. EPH receptors typically have a single kinase domain and an

extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors

have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships,

ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a

glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family

of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and

their affinities for binding ephrin-A and ephrin-B ligands. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: EFNA5_HUMAN, P52803

Function: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for

migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph

receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The

signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway

downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a

caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling

event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion

and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be

important for lens transparency maintenance. May function actively to stimulate axon fasciculation. The interaction of

EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin

secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell

adhesion and repulsion

Gene Wiki entry for EFNA5 (Ephrin-A5)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_034772.6

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the EFNA5 gene promoter:
STAT5B CREB TBP deltaCREB TFIID STAT5A
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: EFNA5 promoter sequence

Search SABiosciences Chromatin IP Primers for EFNA5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EFNA5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q21 Ensembl cytogenetic band: 5q21.3 HGNC cytogenetic band: 5q21

EFNA5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EFNA5 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M106712: view genomic region (about GC identifiers)

Start:	106,712,590 bp from pter	End:	107,006,596 bp from pter
Size:	294,007 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: EFNA5_HUMAN, P52803 (See protein sequence)

Recommended Name: Ephrin-A5 precursor

Size: 228 amino acids; 26297 Da

Subunit: Binds to EPHB2. Interacts with EPHA8; activates EPHA8 (By similarity). Binds to the receptor tyrosine kinases

EPHA2, EPHA3 and EPHB1. Forms a ternary EFNA5-EPHA3-ADAM10 complex mediating EFNA5 extracellular domain shedding by

ADAM10 which regulates the EFNA5-EPHA3 complex internalization and function

Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor. Membrane, caveola; Lipid-anchor, GPI-anchor.

Note=Compartmentalized in discrete caveolae-like membrane microdomains

2 PDB 3D structures from and Proteopedia for EFNA5:

2X11 (3D)

3MX0 (3D)

Explore the universe of human proteins at neXtProt for EFNA5: NX_P52803

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P52803

EFNA5 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001953.1

ENSEMBL proteins:

ENSP00000328777 ENSP00000426989

Human Recombinant Protein Products for EFNA5:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for EFNA5 (Ephrin-A5)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: EFNA5 OriGene Custom Protein Services for EFNA5
	GenScript Custom Purified and Recombinant Proteins Services for EFNA5
	Novus Biologicals EFNA5 Protein Novus Biologicals EFNA5 Lysate
	Sino Biological Recombinant Protein for EFNA5
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for EFNA5

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	ISS	--
GO:0005901	caveola	IEA	--
GO:0016020	membrane	--	--
GO:0031362	anchored to external side of plasma membrane	IDA	11870224

EFNA5 for ontologies About GeneDecksing

EFNA5 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for EFNA5 (Ephrin-A5)
	Browse OriGene Antibodies OriGene Custom Antibody Services for EFNA5
	GenScript Custom Superior Antibodies Services for EFNA5
	Novus Biologicals EFNA5 Antibodies
	Abcam antibodies for EFNA5
	Uscn Antibodies for EFNA5
	ThermoFisher Antibodies for EFNA5

Assay Products for EFNA5:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for EFNA5
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for EFNA5

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

EFNA5 for domains About GeneDecksing

3 InterPro domains/families:

IPR001799 Ephrin

IPR008972 Cupredoxin

IPR019765 Ephrin_CS

Graphical View of Domain Structure for InterPro Entry P52803

ProtoNet protein and cluster: P52803

1 Blocks protein family: IPB001799 Ephrin signature

UniProtKB/Swiss-Prot: EFNA5_HUMAN, P52803

Similarity: Belongs to the ephrin family

Similarity: Contains 1 ephrin RBD (ephrin receptor-binding) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: EFNA5_HUMAN, P52803