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Aliases for EFNA4 Gene

Aliases for EFNA4 Gene

  • Ephrin A4 2 3 5
  • Ephrin-A4 2 3
  • LERK-4 3 4
  • EPLG4 3 4
  • LERK4 3 4
  • Eph-Related Receptor Tyrosine Kinase Ligand 4 3
  • EPH-Related Receptor Tyrosine Kinase Ligand 4 4
  • Ligand Of Eph-Related Kinase 4 3
  • EFL4 3

External Ids for EFNA4 Gene

Previous HGNC Symbols for EFNA4 Gene

  • EPLG4

Previous GeneCards Identifiers for EFNA4 Gene

  • GC01M148220
  • GC01P150808
  • GC01P151811
  • GC01P152253
  • GC01P151849
  • GC01P153302
  • GC01P126398

Summaries for EFNA4 Gene

Entrez Gene Summary for EFNA4 Gene

  • This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. Three transcript variants that encode distinct proteins have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for EFNA4 Gene

EFNA4 (Ephrin A4) is a Protein Coding gene. Among its related pathways are EPHA forward signaling and Developmental Biology. GO annotations related to this gene include ephrin receptor binding and transmembrane-ephrin receptor activity. An important paralog of this gene is ENSG00000251246.

UniProtKB/Swiss-Prot for EFNA4 Gene

  • Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. May play a role in the interaction between activated B-lymphocytes and dendritic cells in tonsils.

Gene Wiki entry for EFNA4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EFNA4 Gene

Genomics for EFNA4 Gene

Regulatory Elements for EFNA4 Gene

Enhancers for EFNA4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G154998 1.9 FANTOM5 ENCODE dbSUPER 19.6 -59.3 -59280 11.3 MLX CREB3L1 AGO1 ZFP64 YBX1 DMAP1 FEZF1 YY1 SLC30A9 ZNF416 KIAA0907 THBS3 ENSG00000271267 RUSC1-AS1 ZBTB7B EFNA4 ASH1L-AS1 DCST1 KRTCAP2 DPM3
GH01G154351 1.7 Ensembl ENCODE dbSUPER 19.5 -710.5 -710548 3.5 CREB3L1 AGO1 ZFP64 DMAP1 YY1 ZNF143 ZNF263 SP3 MEF2D SSRP1 CHTOP RUSC1-AS1 SLC27A3 THBS3 INTS3 EFNA4 ENSG00000272030 KRTCAP2 ENSG00000238279 DPM3
GH01G155242 1.5 ENCODE dbSUPER 19.5 +180.5 180512 2.9 CREB3L1 FEZF1 YBX1 YY1 ZNF416 ZNF143 ZNF548 ZNF263 SP3 TBX21 KIAA0907 ENSG00000271267 RUSC1-AS1 MSTO2P ASH1L THBS3 PYGO2 LOC101928120 GBA BGLAP
GH01G155856 1.8 FANTOM5 ENCODE dbSUPER 11.3 +795.2 795219 5.7 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 SP3 TBX21 RRNAD1 MSTO2P ASH1L-AS1 ENSG00000271267 KIAA0907 GBA RUSC1-AS1 EFNA4 DCST1 BGLAP
GH01G154606 1.7 FANTOM5 ENCODE dbSUPER 11.3 -455.3 -455267 4.1 HDGF ARNT WRNIP1 ARID4B SIN3A FEZF1 YBX1 ZNF2 YY1 ZNF143 CHRNB2 ENSG00000271267 RUSC1-AS1 CHTOP DPM3 EFNA4 UBE2Q1 DCST1 UBE2Q1-AS1 THBS3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EFNA4 on UCSC Golden Path with GeneCards custom track

Promoters for EFNA4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000014020 269 1201 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A FEZF1 ZNF2 ZNF766 ZNF143

Genomic Location for EFNA4 Gene

Chromosome:
1
Start:
155,063,731 bp from pter
End:
155,069,553 bp from pter
Size:
5,823 bases
Orientation:
Plus strand

Genomic View for EFNA4 Gene

Genes around EFNA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EFNA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EFNA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EFNA4 Gene

Proteins for EFNA4 Gene

  • Protein details for EFNA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52798-EFNA4_HUMAN
    Recommended name:
    Ephrin-A4
    Protein Accession:
    P52798
    Secondary Accessions:
    • C9JHJ8
    • G3XAK2
    • O95457
    • Q5SR71
    • Q6FI57

    Protein attributes for EFNA4 Gene

    Size:
    201 amino acids
    Molecular mass:
    22386 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for EFNA4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EFNA4 Gene

Post-translational modifications for EFNA4 Gene

  • Glycosylation at Asn33
  • Modification sites at PhosphoSitePlus

Other Protein References for EFNA4 Gene

No data available for DME Specific Peptides for EFNA4 Gene

Domains & Families for EFNA4 Gene

Gene Families for EFNA4 Gene

Protein Domains for EFNA4 Gene

Suggested Antigen Peptide Sequences for EFNA4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P52798

UniProtKB/Swiss-Prot:

EFNA4_HUMAN :
  • Belongs to the ephrin family.
Family:
  • Belongs to the ephrin family.
genes like me logo Genes that share domains with EFNA4: view

Function for EFNA4 Gene

Molecular function for EFNA4 Gene

GENATLAS Biochemistry:
ephrin A-4,eph-related receptor tyrosine kinase,class A,ligand,high affinity,involved in short-range contact-mediated axonal guidance
UniProtKB/Swiss-Prot Function:
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. May play a role in the interaction between activated B-lymphocytes and dendritic cells in tonsils.

Gene Ontology (GO) - Molecular Function for EFNA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005005 transmembrane-ephrin receptor activity TAS 8660976
GO:0005515 protein binding IPI 15777695
GO:0046875 ephrin receptor binding IPI 15777695
genes like me logo Genes that share ontologies with EFNA4: view
genes like me logo Genes that share phenotypes with EFNA4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for EFNA4

miRNA for EFNA4 Gene

miRTarBase miRNAs that target EFNA4

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EFNA4 Gene

Localization for EFNA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EFNA4 Gene

Isoform 1: Cell membrane; Lipid-anchor, GPI-anchor.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EFNA4 gene
Compartment Confidence
plasma membrane 5
extracellular 4

Gene Ontology (GO) - Cellular Components for EFNA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS,IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8660976
GO:0016020 membrane IEA --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with EFNA4: view

Pathways & Interactions for EFNA4 Gene

genes like me logo Genes that share pathways with EFNA4: view

SIGNOR curated interactions for EFNA4 Gene

Activates:

Gene Ontology (GO) - Biological Process for EFNA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007267 cell-cell signaling TAS 8660976
GO:0048013 ephrin receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with EFNA4: view

Drugs & Compounds for EFNA4 Gene

(1) Drugs for EFNA4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with EFNA4: view

Transcripts for EFNA4 Gene

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EFNA4 Gene

No ASD Table

Relevant External Links for EFNA4 Gene

GeneLoc Exon Structure for
EFNA4
ECgene alternative splicing isoforms for
EFNA4

Expression for EFNA4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EFNA4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EFNA4 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x4.8) and Skin - Not Sun Exposed (Suprapubic) (x4.4).

Protein differential expression in normal tissues from HIPED for EFNA4 Gene

This gene is overexpressed in Lymph node (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for EFNA4 Gene



Protein tissue co-expression partners for EFNA4 Gene

NURSA nuclear receptor signaling pathways regulating expression of EFNA4 Gene:

EFNA4

SOURCE GeneReport for Unigene cluster for EFNA4 Gene:

Hs.449913

mRNA Expression by UniProt/SwissProt for EFNA4 Gene:

P52798-EFNA4_HUMAN
Tissue specificity: Expressed in the adult spleen, lymph node, prostate, ovary, small intestine, and colon, and in fetal heart, lung, liver and kidney. Also detected in hematopoietic cell lines.
genes like me logo Genes that share expression patterns with EFNA4: view

Primer Products

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for EFNA4 Gene

Orthologs for EFNA4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for EFNA4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EFNA4 34 35
  • 99.83 (n)
dog
(Canis familiaris)
Mammalia EFNA4 34 35
  • 87.64 (n)
cow
(Bos Taurus)
Mammalia EFNA4 34 35
  • 86.7 (n)
mouse
(Mus musculus)
Mammalia Efna4 34 16 35
  • 85.23 (n)
rat
(Rattus norvegicus)
Mammalia Efna4 34
  • 85.14 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia EFNA4 35
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EFNA4 35
  • 69 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC100003450 34
  • 56.18 (n)
Species where no ortholog for EFNA4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EFNA4 Gene

ENSEMBL:
Gene Tree for EFNA4 (if available)
TreeFam:
Gene Tree for EFNA4 (if available)

Paralogs for EFNA4 Gene

Paralogs for EFNA4 Gene

(4) SIMAP similar genes for EFNA4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with EFNA4: view

Variants for EFNA4 Gene

Sequence variations from dbSNP and Humsavar for EFNA4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000261643 -- 155,066,531(+) GAATC(G/T)ATCAT intron-variant
rs1001331677 -- 155,064,591(+) AGGCT(C/T)AGGCT intron-variant, upstream-variant-2KB
rs1001368419 -- 155,064,090(+) GGCGA(A/G)GGGCG intron-variant, upstream-variant-2KB
rs1001418155 -- 155,064,808(+) GTGCC(C/T)GGCCC intron-variant, upstream-variant-2KB
rs1002068673 -- 155,069,944(+) GCCTG(A/G)CCTAG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for EFNA4 Gene

Variant ID Type Subtype PubMed ID
esv3587615 CNV gain 21293372
esv3587616 CNV gain 21293372
nsv509502 CNV insertion 20534489
nsv952212 CNV deletion 24416366

Variation tolerance for EFNA4 Gene

Residual Variation Intolerance Score: 76.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EFNA4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EFNA4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EFNA4 Gene

Disorders for EFNA4 Gene

Relevant External Links for EFNA4

Genetic Association Database (GAD)
EFNA4
Human Genome Epidemiology (HuGE) Navigator
EFNA4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EFNA4

No disorders were found for EFNA4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EFNA4 Gene

Publications for EFNA4 Gene

  1. A splice variant of human ephrin-A4 encodes a soluble molecule that is secreted by activated human B lymphocytes. (PMID: 10607706) Aasheim H.-C. … Logtenberg T. (Blood 2000) 3 4 22 64
  2. The genes encoding the eph-related receptor tyrosine kinase ligands LERK-1 (EPLG1, Epl1), LERK-3 (EPLG3, Epl3), and LERK-4 (EPLG4, Epl4) are clustered on human chromosome 1 and mouse chromosome 3. (PMID: 8660976) Cerretti D.P. … Morris S.W. (Genomics 1996) 2 3 22 64
  3. Ephrin A4 expression in osteosarcoma, impact on prognosis, and patient outcome. (PMID: 20071790) Abdou A.G. … Abdallaha R. (Indian J Cancer 2010) 3 22 64
  4. Prevalence and complications of single-gene and chromosomal disorders in craniosynostosis. (PMID: 20643727) Wilkie A.O. … Wall S.A. (Pediatrics 2010) 3 46 64
  5. Expression profile of Eph receptors and ephrin ligands in healthy human B lymphocytes and chronic lymphocytic leukemia B-cells. (PMID: 18819711) Alonso-C L.M. … Zapata A.G. (Leuk. Res. 2009) 3 22 64

Products for EFNA4 Gene

Sources for EFNA4 Gene

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