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Aliases for EFNA3 Gene

Aliases for EFNA3 Gene

  • Ephrin-A3 2 3
  • EPLG3 3 4 6
  • EHK1 Ligand 3 4
  • Ehk1-L 3 4
  • LERK-3 3 4
  • EFL-2 3 4
  • LERK3 3 4
  • EFL2 3 4
  • Eph-Related Receptor Tyrosine Kinase Ligand 3 3
  • EPH-Related Receptor Tyrosine Kinase Ligand 3 4
  • Ligand Of Eph-Related Kinase 3 3

External Ids for EFNA3 Gene

Previous Symbols for EFNA3 Gene

  • EPLG3

Summaries for EFNA3 Gene

Entrez Gene Summary for EFNA3 Gene

  • This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. [provided by RefSeq, Jul 2008]

GeneCards Summary for EFNA3 Gene

EFNA3 (Ephrin-A3) is a Protein Coding gene. Diseases associated with EFNA3 include androgenic alopecia. Among its related pathways are PI3K-Akt signaling pathway and Ras signaling pathway. GO annotations related to this gene include ephrin receptor binding and transmembrane-ephrin receptor activity. An important paralog of this gene is EFNA2.

UniProtKB/Swiss-Prot for EFNA3 Gene

  • Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity).

Gene Wiki entry for EFNA3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EFNA3 Gene

Genomics for EFNA3 Gene

Genomic Location for EFNA3 Gene

Start:
155,078,872 bp from pter
End:
155,087,538 bp from pter
Size:
8,667 bases
Orientation:
Plus strand

Genomic View for EFNA3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EFNA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EFNA3 Gene

Regulatory Elements for EFNA3 Gene

Proteins for EFNA3 Gene

  • Protein details for EFNA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52797-EFNA3_HUMAN
    Recommended name:
    Ephrin-A3
    Protein Accession:
    P52797
    Secondary Accessions:
    • B7ZAD3
    • D3DV85
    • Q0VGC9
    • Q5SR70

    Protein attributes for EFNA3 Gene

    Size:
    238 amino acids
    Molecular mass:
    26350 Da
    Quaternary structure:
    • Interacts with EPHA8; activates EPHA8

    Alternative splice isoforms for EFNA3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EFNA3 Gene

Proteomics data for EFNA3 Gene at MOPED

Post-translational modifications for EFNA3 Gene

  • Glycosylation at Asn38, Asn67, and Asn100

Other Protein References for EFNA3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EFNA3 Gene

Domains for EFNA3 Gene

Gene Families for EFNA3 Gene

HGNC:

Protein Domains for EFNA3 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P52797

UniProtKB/Swiss-Prot:

EFNA3_HUMAN
Domain:
  • Contains 1 ephrin RBD (ephrin receptor-binding) domain.:
    • P52797
Family:
  • Belongs to the ephrin family.:
    • P52797
genes like me logo Genes that share domains with EFNA3: view

Function for EFNA3 Gene

Molecular function for EFNA3 Gene

GENATLAS Biochemistry: ephrin A-3,eph-related receptor tyrosine kinase,class A,ligand,high affinity,involved in short-range contact-mediated axonal guidance
UniProtKB/Swiss-Prot Function: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity).

Gene Ontology (GO) - Molecular Function for EFNA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005005 transmembrane-ephrin receptor activity TAS 8660976
GO:0005515 protein binding IPI 25416956
GO:0046875 ephrin receptor binding IPI 15777695
genes like me logo Genes that share ontologies with EFNA3: view
genes like me logo Genes that share phenotypes with EFNA3: view

Animal Models for EFNA3 Gene

MGI Knock Outs for EFNA3:

miRNA for EFNA3 Gene

miRTarBase miRNAs that target EFNA3

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for EFNA3 Gene

Localization for EFNA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EFNA3 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EFNA3 Gene COMPARTMENTS Subcellular localization image for EFNA3 gene
Compartment Confidence
plasma membrane 5
extracellular 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for EFNA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8660976
GO:0016020 membrane --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with EFNA3: view

Pathways for EFNA3 Gene

genes like me logo Genes that share pathways with EFNA3: view

Gene Ontology (GO) - Biological Process for EFNA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007267 cell-cell signaling TAS 8660976
GO:0007411 axon guidance TAS --
GO:0048013 ephrin receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with EFNA3: view

Compounds for EFNA3 Gene

(1) Novoseek inferred chemical compound relationships for EFNA3 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 44.8 1
genes like me logo Genes that share compounds with EFNA3: view

Transcripts for EFNA3 Gene

mRNA/cDNA for EFNA3 Gene

Unigene Clusters for EFNA3 Gene

Ephrin-A3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EFNA3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b
SP1: - -
SP2: - -
SP3:
SP4: -

Relevant External Links for EFNA3 Gene

GeneLoc Exon Structure for
EFNA3
ECgene alternative splicing isoforms for
EFNA3

Expression for EFNA3 Gene

mRNA expression in normal human tissues for EFNA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EFNA3 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (11.7), Skin - Sun Exposed (Lower leg) (9.8), and Esophagus - Mucosa (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for EFNA3 Gene

SOURCE GeneReport for Unigene cluster for EFNA3 Gene Hs.516656

mRNA Expression by UniProt/SwissProt for EFNA3 Gene

P52797-EFNA3_HUMAN
Tissue specificity: Expressed in brain, skeletal muscle, spleen, thymus, prostate, testis, ovary, small intestine, and peripheral blood leukocytes
genes like me logo Genes that share expressions with EFNA3: view

Orthologs for EFNA3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for EFNA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EFNA3 35
  • 99.86 (n)
  • 100 (a)
EFNA3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EFNA3 35
  • 95.99 (n)
  • 97.69 (a)
EFNA3 36
  • 98 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 97 (a)
OneToMany
EFNA3 35
  • 93.52 (n)
  • 96.76 (a)
mouse
(Mus musculus)
Mammalia Efna3 35
  • 93.91 (n)
  • 95.19 (a)
Efna3 16
Efna3 36
  • 97 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 96 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Efna3 35
  • 92.95 (n)
  • 95.19 (a)
African clawed frog
(Xenopus laevis)
Amphibia efna3-prov 35
zebrafish
(Danio rerio)
Actinopterygii efna3 35
efna3a 36
  • 63 (a)
ManyToMany
efna3b 36
  • 65 (a)
ManyToMany
Species with no ortholog for EFNA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EFNA3 Gene

ENSEMBL:
Gene Tree for EFNA3 (if available)
TreeFam:
Gene Tree for EFNA3 (if available)

Paralogs for EFNA3 Gene

Paralogs for EFNA3 Gene

Selected SIMAP similar genes for EFNA3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with EFNA3: view

Variants for EFNA3 Gene

Sequence variations from dbSNP and Humsavar for EFNA3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1462854 -- 155,081,206(+) CCCTC(A/T)GCCCC intron-variant
rs1462855 -- 155,081,243(+) TGGAA(C/T)AGGAG intron-variant
rs1531478 -- 155,085,204(+) cggag(A/G)cgggg missense, reference
rs1870939 -- 155,083,020(+) TCAGG(A/G)GCTGT intron-variant
rs2306123 -- 155,087,330(+) AGACA(A/G)GACCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for EFNA3 Gene

Variant ID Type Subtype PubMed ID
nsv509502 CNV Insertion 20534489
nsv872454 CNV Loss 21882294
nsv872455 CNV Loss 21882294

Relevant External Links for EFNA3 Gene

HapMap Linkage Disequilibrium report
EFNA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EFNA3 Gene

Disorders for EFNA3 Gene

(1) MalaCards Diseases for EFNA3 Gene

Search for EFNA3 Gene in MalaCards »

(1) Novoseek inferred disease relationships for EFNA3 Gene

Disease -log(P) Hits PubMed IDs
tumors 6.59 2

Relevant External Links for EFNA3

Genetic Association Database (GAD)
EFNA3
Human Genome Epidemiology (HuGE) Navigator
EFNA3
genes like me logo Genes that share disorders with EFNA3: view

No data available for UniProtKB/Swiss-Prot for EFNA3 Gene

Publications for EFNA3 Gene

  1. The genes encoding the eph-related receptor tyrosine kinase ligands LERK-1 (EPLG1, Epl1), LERK-3 (EPLG3, Epl3), and LERK-4 (EPLG4, Epl4) are clustered on human chromosome 1 and mouse chromosome 3. (PMID: 8660976) Cerretti D.P. … Morris S.W. (Genomics 1996) 2 3 23
  2. A role for the Eph ligand ephrin-A3 in entorhino-hippocampal axon targeting. (PMID: 10516308) Stein E. … Skutella T. (J. Neurosci. 1999) 3 23
  3. MicroRNA-210 modulates endothelial cell response to hypoxia and inhibits the receptor tyrosine kinase ligand Ephrin-A3. (PMID: 18417479) Fasanaro P. … Martelli F. (J. Biol. Chem. 2008) 3 23
  4. Human dendritic cells express neuronal Eph receptor tyrosine kinases: role of EphA2 in regulating adhesion to fibronectin. (PMID: 12907451) de Saint-Vis B. … Garrone P. (Blood 2003) 3 23
  5. Ligands for the receptor tyrosine kinases hek and elk: isolation of cDNAs encoding a family of proteins. (PMID: 7838529) Kozlosky C.J. … Beckmann M.P. (Oncogene 1995) 3 4

Products for EFNA3 Gene

Sources for EFNA3 Gene

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