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EFNA3 Gene

protein-coding   GIFtS: 64
GCID: GC01P155051

Ephrin-A3


(Previous symbol: EPLG3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ephrin-A31 2     LERK32 3
EPLG31 2 3 5     EHK1 Ligand2 3
EPH-Related Receptor Tyrosine Kinase Ligand 32 3     Ehk1-L2
EFL-22 3     Ligand Of Eph-Related Kinase 32
EFL22 3     EHK1-L3
LERK-32 3     

External Ids:    HGNC: 32231   Entrez Gene: 19442   Ensembl: ENSG000001435907   OMIM: 6013815   UniProtKB: P527973   

Export aliases for EFNA3 gene to outside databases

Previous GC identifers: GC01P148129 GC01M150765 GC01P151826 GC01P152268 GC01P151864 GC01P153317 GC01P155039 GC01P126413


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for EFNA3 Gene:
This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest
subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events,
especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships,
ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a
glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene
encodes an EFNA class ephrin. (provided by RefSeq, Jul 2008)

GeneCards Summary for EFNA3 Gene:
EFNA3 (ephrin-A3) is a protein-coding gene. Diseases associated with EFNA3 include androgenic alopecia, and alopecia. GO annotations related to this gene include transmembrane-ephrin receptor activity and ephrin receptor binding. An important paralog of this gene is EFNA1.

UniProtKB/Swiss-Prot: EFNA3_HUMAN, P52797
Function: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial
for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously
Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring
cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling
pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity)

Gene Wiki entry for EFNA3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the EFNA3 gene promoter:
         E2F-3a   E2F   E2F-1   p53   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEFNA3 promoter sequence
   Search Chromatin IP Primers for EFNA3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EFNA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21-q22   Ensembl cytogenetic band:  1q22   HGNC cytogenetic band: 1q21-q22

EFNA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EFNA3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P155051:  view genomic region     (about GC identifiers)

Start:
155,036,224 bp from pter      End:
155,060,014 bp from pter
Size:
23,791 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: EFNA3_HUMAN, P52797 (See protein sequence)
Recommended Name: Ephrin-A3 precursor  
Size: 238 amino acids; 26350 Da
Subunit: Interacts with EPHA8; activates EPHA8
Secondary accessions: D3DV85 Q0VGC9 Q5SR70

Explore the universe of human proteins at neXtProt for EFNA3: NX_P52797

Explore proteomics data for EFNA3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn38, Asn67, Asn100

  • See EFNA3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004943.1  
    ENSEMBL proteins: 
     ENSP00000357393   ENSP00000450814   ENSP00000391370  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    EFN: Ephrins

    3 InterPro protein domains:
     IPR001799 Ephrin
     IPR008972 Cupredoxin
     IPR019765 Ephrin_CS

    Graphical View of Domain Structure for InterPro Entry P52797

    ProtoNet protein and cluster: P52797

    1 Blocks protein domain: IPB001799 Ephrin signature

    UniProtKB/Swiss-Prot: EFNA3_HUMAN, P52797
    Similarity: Belongs to the ephrin family
    Similarity: Contains 1 ephrin RBD (ephrin receptor-binding) domain


    EFNA3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EFNA3_HUMAN, P52797
    Function: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial
    for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously
    Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring
    cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling
    pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity)

         Genatlas biochemistry entry for EFNA3:
    ephrin A-3,eph-related receptor tyrosine kinase,class A,ligand,high affinity,involved in short-range
    contact-mediated axonal guidance

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005005transmembrane-ephrin receptor activity TAS8660976
    GO:0046875ephrin receptor binding IPI15777695
         
    EFNA3 for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Efna3):
     behavior/neurological  growth/size/body  mortality/aging  nervous system  normal 

    EFNA3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Efna3tm1Rax for EFNA3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EFNA3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EFNA3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EFNA3

    miRNA
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    miRTarBase miRNAs that target EFNA3:
    hsa-mir-210-3p (MIRT002024)

    Block miRNA regulation of human, mouse, rat EFNA3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EFNA3 (see all 41):
    hsa-miR-323-3p hsa-miR-1321 hsa-miR-3607-3p hsa-miR-3664-5p hsa-miR-330-5p hsa-miR-513a-5p hsa-miR-30d hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidEFNA3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for EFNA3
    Predesigned siRNA for gene silencing in human, mouse, rat EFNA3

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: EFNA3 (NM_004952)
    Sino Biological Human cDNA Clone for EFNA3
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EFNA3

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EFNA3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EFNA3_HUMAN, P52797: Cell membrane; Lipid-anchor, GPI-anchor
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    endoplasmic reticulum1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IBA--
    GO:0005887integral component of plasma membrane TAS8660976
    GO:0016020membrane ----
    GO:0031225anchored component of membrane IEA--

    EFNA3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for EFNA3 About   (see all 11)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Ras signaling pathway
    Rap1 signaling pathway0.36
    Ras signaling pathway0.36
    2EphB-EphrinB Signaling
    Ephrin-Eph Signaling0.58
    3Development Slit Robo signaling
    Neurophysiological process Receptor mediated axon growth repulsion0.41
    4EPHB forward signaling
    Cell adhesion Ephrins signaling0.30
    5PI3K-Akt signaling pathway
    PI3K-Akt signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for EFNA3
        Guidance Cues and Growth Cone Motility
    Ephrin-Eph Signaling
    EphrinA-EphR Signaling

    3 GeneGo (Thomson Reuters) Pathways for EFNA3
        Neurophysiological process Receptor-mediated axon growth repulsion
    G-protein signaling RhoA regulation pathway
    Cell adhesion Ephrins signaling

    1 BioSystems Pathway for EFNA3
        EPHA forward signaling



    5 Kegg Pathways  (Kegg details for EFNA3):
        Ras signaling pathway
    Rap1 signaling pathway
    PI3K-Akt signaling pathway
    Axon guidance
    MicroRNAs in cancer


    EFNA3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for EFNA3
    Interactions:

        GeneGlobe Interaction Network for EFNA3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for EFNA3 (P527972, 3 ENSP000003573934) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRSS23O950842, 3MINT-63247 I2D: score=5 
    EPHA2P293173, ENSP000003512094I2D: score=3 STRING: ENSP00000351209
    EPHA7Q153753, ENSP000003583094I2D: score=3 STRING: ENSP00000358309
    EPHA4P547643, ENSP000002818214I2D: score=2 STRING: ENSP00000281821
    EPHA5P547563, ENSP000002738544I2D: score=1 STRING: ENSP00000273854
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007267cell-cell signaling TAS8660976
    GO:0007411axon guidance IBA--
    GO:0048013ephrin receptor signaling pathway ISS--

    EFNA3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EFNA3

    1 Novoseek inferred chemical compound relationship for EFNA3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 44.8 2 8660976 (1)



    EFNA3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for EFNA3 gene: 
    NM_004952.4  

    Unigene Cluster for EFNA3:

    Ephrin-A3
    Hs.516656  [show with all ESTs]
    Unigene Representative Sequence: BC110406
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368408(uc010pew.2 uc001fhf.3 uc010pex.2) ENST00000470294
    ENST00000498667 ENST00000556931 ENST00000418360
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate EFNA3 (see all 41):
    hsa-miR-323-3p hsa-miR-1321 hsa-miR-3607-3p hsa-miR-3664-5p hsa-miR-330-5p hsa-miR-513a-5p hsa-miR-30d hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidEFNA3 3' UTR sequence
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EFNA3
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      QuantiFast Probe-based Assays in human, mouse, rat EFNA3

    Additional mRNA sequence: 

    AK296030.1 AK316248.1 BC017722.1 BC110406.1 L37360.1 U14187.1 

    6 DOTS entries:

    DT.401756  DT.100684719  DT.91711109  DT.91810237  DT.92422077  DT.121413958 

    Selected AceView cDNA sequences (see all 37):

    CR607482 BG743158 L37360 NM_004952 BE138904 BU619334 U14187 BU633345 
    CR597504 BC017722 BE048061 AI272654 BU634071 AL533153 BF969747 BF968137 
    BU623218 BX419695 BF983120 BG499730 AA338749 AW780303 T32108 AI282890 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for EFNA3    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b
    SP1:                          -           -                     
    SP2:                                      -     -               
    SP3:                                                            
    SP4:                          -                                 


    ECgene alternative splicing isoforms for EFNA3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EFNA3 expression in normal human tissues (normalized intensities)      EFNA3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACAGACTCT
    EFNA3 Expression
    About this image


    EFNA3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
    EFNA3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EFNA3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.516656

    UniProtKB/Swiss-Prot: EFNA3_HUMAN, P52797
    Tissue specificity: Expressed in brain, skeletal muscle, spleen, thymus, prostate, testis, ovary, small intestine,
    and peripheral blood leukocytes

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EFNA3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for EFNA3 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Efna31 , 5 ephrin A31, 5 93.91(n)1
    95.19(a)1
      3 (39.06 cM)5
    136381  NM_010108.11  NP_034238.11 
     893138995 
    African clawed frog
    (Xenopus laevis)
    Amphibia efna3-prov2 ephrin A3 82.92(n)    BC054997.1 
    zebrafish
    (Danio rerio)
    Actinopterygii efna32 ephrin A3 80.02(n)   117506  AB051678.1 


    ENSEMBL Gene Tree for EFNA3 (if available)
    TreeFam Gene Tree for EFNA3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for EFNA3 gene
    EFNA12  EFNA22  EFNA52  EFNA42  ENSG000002512462  
    4 SIMAP similar genes for EFNA3 using alignment to 3 protein entries:     EFNA3_HUMAN (see all proteins):
    EFNA5    EFNA2    EFNA4    EFNA1

    EFNA3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for EFNA3 (see all 166)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs37669161,2
    C,F,A,H--155049402(+) TCCTGC/TAGAGA 1 -- us2k133Minor allele frequency- T:0.24EA NS NA WA CSA 4608
    rs727022691,2
    C,F--155049414(+) GGCTCC/TGGATT 1 -- us2k12Minor allele frequency- T:0.05WA NA 238
    rs1503969201,2
    --155049583(+) CCAAAC/TCAGCA 1 -- us2k10--------
    rs1819703041,2
    --155049705(+) TTGTGA/GCACCT 1 -- us2k10--------
    rs601575271,2
    C,F--155049771(+) CCTGCA/GGGGAG 1 -- us2k12Minor allele frequency- G:0.12WA 120
    rs1381274191,2
    --155049844(+) TGAGAA/GGGAAG 1 -- us2k10--------
    rs1438503331,2
    C--155050197(+) TGAACC/GCTTTT 1 -- us2k10--------
    rs1472613371,2
    C--155050276(+) GGTTTA/GTGTGT 1 -- us2k10--------
    rs1870623561,2
    --155050502(+) TGAGGA/GCAATG 1 -- us2k10--------
    rs1163450561,2
    F--155050559(+) GATCAG/ACGTCT 1 -- us2k11Minor allele frequency- A:0.03WA 118

    HapMap Linkage Disequilibrium report for EFNA3 (155036224 - 155060014 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for EFNA3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509502CNV Insertion20534489
    nsv872455CNV Loss21882294
    nsv872454CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601381    OMIM disorders: --

    10 diseases for EFNA3:    About MalaCards
    androgenic alopecia    alopecia    osteosarcoma    hypoxia
    cerebritis    alzheimer's disease    endotheliitis    neuronitis
    prostate cancer    prostatitis


    EFNA3 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for EFNA3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 6.59 2 12209731 (1), 16516143 (1)

    Genetic Association Database (GAD): EFNA3
    Human Genome Epidemiology (HuGE) Navigator: EFNA3 (1 document)

    Export disorders for EFNA3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EFNA3 gene, integrated from 10 sources (see all 39):
    (articles sorted by number of sources associating them with EFNA3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The genes encoding the eph-related receptor tyrosine kinase ligands LERK-1 (EPLG1, Epl1), LERK-3 (EPLG3, Epl3), and LERK-4 (EPLG4, Epl4) are clustered on human chromosome 1 and mouse chromosome 3. (PubMed id 8660976)1, 3, 9 Cerretti D.P....Morris S.W. (Genomics 1996)
    2. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PubMed id 19204726)1, 4 Chapuis J....Lambert J.C. (Mol. Psychiatry 2009)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Ligands for the receptor tyrosine kinases hek and elk: isolation of cDNAs encoding a family of proteins. (PubMed id 7838529)1, 2 Kozlosky C.J.... Beckmann M.P. (Oncogene 1995)
    6. Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity. (PubMed id 7973638)1, 2 Davis S.... Yancopoulos G.D. (Science 1994)
    7. MicroRNA-210 modulates endothelial cell response to hypoxia and inhibits the receptor tyrosine kinase ligand Ephrin-A3. (PubMed id 18417479)1, 9 Fasanaro P....Martelli F. (J. Biol. Chem. 2008)
    8. A role for the Eph ligand ephrin-A3 in entorhino-hippocampal axon targeting. (PubMed id 10516308)1, 9 Stein E....Skutella T. (J. Neurosci. 1999)
    9. Human dendritic cells express neuronal Eph receptor tyrosine kinases: role of EphA2 in regulating adhesion to fibronectin. (PubMed id 12907451)1, 9 de Saint-Vis B....Garrone P. (Blood 2003)
    10. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PubMed id 23535732)1 Eeles R.A....Easton D.F. (Nat. Genet. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1944 HGNC: 3223 AceView: EFNA3 Ensembl:ENSG00000143590 euGenes: HUgn1944
    ECgene: EFNA3 Kegg: 1944 H-InvDB: EFNA3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for EFNA3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for EFNA3 gene:
    Search GeneIP for patents involving EFNA3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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