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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EFNA3 Gene

protein-coding   GIFtS: 61
GCID: GC01P155051

ephrin-A3


(Previous symbol: EPLG3)
 Explore 9 diseases affiliated with
EFNA3 via our new
 Human Malady Compendium 
Biological research products
for EFNA3
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Ephrin-A31     EFL22 3
EPLG31 2 3 5     LERK-32 3
LERK31 2 3     EHK1 Ligand2 3
Ehk1-L1 2     Ligand Of Eph-Related Kinase 32
EPH-Related Receptor Tyrosine Kinase Ligand 32 3     EHK1-L3
EFL-22 3     

External Ids:    HGNC: 32231   Entrez Gene: 19442   Ensembl: ENSG000001435907   OMIM: 6013815   UniProtKB: P527973   

Export aliases for EFNA3 gene to outside databases

Previous GC identifers: GC01P148129 GC01M150765 GC01P151826 GC01P152268 GC01P151864 GC01P153317 GC01P155039 GC01P126413


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for EFNA3:
This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest
subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially
in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided
into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the
ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. (provided by RefSeq,
Jul 2008)

UniProtKB/Swiss-Prot: EFNA3_HUMAN, P52797
Function: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for
migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph
receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The
signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway
downstream of the ephrin ligand is referred to as reverse signaling (By similarity)

Gene Wiki entry for EFNA3


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EFNA3 gene promoter:
         E2F-3a   E2F   E2F-1   p53   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEFNA3 promoter sequence
   Search SABiosciences Chromatin IP Primers for EFNA3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EFNA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21-q22   Ensembl cytogenetic band:  1q22   HGNC cytogenetic band: 1q21-q22

EFNA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EFNA3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P155051:  view genomic region     (about GC identifiers)

Start:
155,036,224 bp from pter      End:
155,060,014 bp from pter
Size:
23,791 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: EFNA3_HUMAN, P52797 (See protein sequence)
Recommended Name: Ephrin-A3 precursor  
Size: 238 amino acids; 26350 Da
Subunit: Interacts with EPHA8; activates EPHA8
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor
Secondary accessions: D3DV85 Q0VGC9 Q5SR70

Explore the universe of human proteins at neXtProt for EFNA3: NX_P52797

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P52797

  • EFNA3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004943.1  
    ENSEMBL proteins: 
     ENSP00000357393   ENSP00000450814   ENSP00000391370  

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    Novus Biologicals EFNA3 Lysates
    Sino Biological Recombinant Protein for EFNA3
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for EFNA3

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane TAS8660976
    GO:0016020membrane ----
    GO:0031225anchored to membrane IEA--


    EFNA3 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    EFNA3 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001799 Ephrin
     IPR008972 Cupredoxin
     IPR019765 Ephrin_CS

    Graphical View of Domain Structure for InterPro Entry P52797

    ProtoNet protein and cluster: P52797

    1 Blocks protein family: IPB001799 Ephrin signature

    UniProtKB/Swiss-Prot: EFNA3_HUMAN, P52797
    Similarity: Belongs to the ephrin family
    Similarity: Contains 1 ephrin RBD (ephrin receptor-binding) domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: EFNA3_HUMAN, P52797
    Function: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for
    migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph
    receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The
    signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway
    downstream of the ephrin ligand is referred to as reverse signaling (By similarity)

         Genatlas biochemistry entry for EFNA3:
    ephrin A-3,eph-related receptor tyrosine kinase,class A,ligand,high affinity,involved in short-range contact-mediated
    axonal guidance

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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EFNA3
    8/41 QIAGEN miScript miRNA Assays for microRNAs that regulate EFNA3 (see all 41):
    hsa-miR-323-3p hsa-miR-1321 hsa-miR-3607-3p hsa-miR-3664-5p hsa-miR-330-5p hsa-miR-513a-5p hsa-miR-30d hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidEFNA3 3' UTR sequence
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EFNA3

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005005transmembrane-ephrin receptor activity TAS8660976
    GO:0046875ephrin receptor binding IPI15777695


    EFNA3 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Efna3tm1Rax for EFNA3
         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Efna3):
     behavior/neurological  growth/size  mortality/aging  nervous system  normal 

    EFNA3 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1G-protein signaling_RhoA regulation pathway
    G-protein signaling_RhoA regulation pathway1.00
    EphrinA-EphR Signaling0.26
    G-protein signaling RhoA regulation pathway1.00
    2Cell adhesion_Ephrins signaling
    Cell adhesion Ephrins signaling1.00
    Cell adhesion_Ephrins signaling1.00
    3Neurophysiological process Receptor-mediated axon growth repulsion
    Neurophysiological process Receptor-mediated axon growth repulsion1.00
    Neurophysiological process_Receptor-mediated axon growth repulsion0.94
    4Guidance Cues and Growth Cone Motility
    Guidance Cues and Growth Cone Motility1.00
    5EPHA forward signaling
    EPHA forward signaling1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 EMD Millipore Pathways for EFNA3
        Neurophysiological process Receptor-mediated axon growth repulsion
    Cell adhesion Ephrins signaling
    G-protein signaling RhoA regulation pathway

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for EFNA3
        Guidance Cues and Growth Cone Motility
    Ephrin-Eph Signaling
    EphrinA-EphR Signaling

    3 GeneGo (Thomson Reuters) Pathways for EFNA3
        Neurophysiological process Receptor-mediated axon growth repulsion
    G-protein signaling RhoA regulation pathway
    Cell adhesion Ephrins signaling

    1 BioSystems Pathway for EFNA3 
        EPHA forward signaling


    1         Kegg Pathway  (Kegg details for EFNA3):
        Axon guidance


    EFNA3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for EFNA3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/14 Interacting proteins for EFNA3 (P527972, 3 ENSP000003573934) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRSS23O950842, 3MINT-63247 I2D: score=5 
    EPHA2P293173, ENSP000003512094I2D: score=3 STRING: ENSP00000351209
    EPHA7Q153753, ENSP000003583094I2D: score=3 STRING: ENSP00000358309
    EPHA4P547643, ENSP000002818214I2D: score=2 STRING: ENSP00000281821
    EPHA5P547563, ENSP000002738544I2D: score=1 STRING: ENSP00000273854
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007267cell-cell signaling TAS8660976
    GO:0048013ephrin receptor signaling pathway ISS--


    EFNA3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    EFNA3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for EFNA3
    1 Novoseek chemical compound relationship for EFNA3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 44.8 2 8660976 (1)

    Search CenterWatch for drugs/clinical trials and news about EFNA3 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for EFNA3 gene: 
    NM_004952.4  

    Unigene Cluster for EFNA3:

    Ephrin-A3
    Hs.516656  [show with all ESTs]
    Unigene Representative Sequence: BC110406
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368408(uc010pew.2 uc001fhf.3 uc010pex.2) ENST00000470294
    ENST00000498667 ENST00000556931 ENST00000418360

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    hsa-miR-323-3p hsa-miR-1321 hsa-miR-3607-3p hsa-miR-3664-5p hsa-miR-330-5p hsa-miR-513a-5p hsa-miR-30d hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidEFNA3 3' UTR sequence
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    Additional cDNA sequence: 

    AK296030.1 AK316248.1 BC017722.1 BC110406.1 L37360.1 U14187.1 

    6 DOTS entries:

    DT.401756  DT.100684719  DT.91711109  DT.91810237  DT.92422077  DT.121413958 

    24/37 AceView cDNA sequences (see all 37):

    BU633345 BG743158 L37360 BU619334 CR597504 U14187 BE048061 BC017722 
    CR607482 BE138904 NM_004952 BF968137 AL533153 BX419695 BG499730 BU634071 
    BF983120 AA338749 BU623218 AI272654 BF969747 AW189015 AI282890 BG698896 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for EFNA3    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b
    SP1:                          -           -                     
    SP2:                                      -     -               
    SP3:                                                            
    SP4:                          -                                 


    ECgene alternative splicing isoforms for EFNA3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EFNA3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TACAGACTCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See EFNA3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EFNA3

    SOURCE GeneReport for Unigene cluster: Hs.516656

    UniProtKB/Swiss-Prot: EFNA3_HUMAN, P52797
    Tissue specificity: Expressed in brain, skeletal muscle, spleen, thymus, prostate, testis, ovary, small intestine, and
    peripheral blood leukocytes

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EFNA3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for EFNA3 gene from 2/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    African clawed frog
    (Xenopus laevis)
    Amphibia efna3-prov2 ephrin A3 82.92(n)    BC054997.1 
    zebrafish
    (Danio rerio)
    Actinopterygii efna32 ephrin A3 80.02(n)   117506  AB051678.1 


    ENSEMBL Gene Tree for EFNA3 (if available)
    TreeFam Gene Tree for EFNA3 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for EFNA3 gene
    EFNA22  EFNA12  EFNA52  EFNA42  ENSG000002512462  
    4 SIMAP similar genes for EFNA3 using alignment to 3 protein entries:     EFNA3_HUMAN (see all proteins):
    EFNA5    EFNA2    EFNA4    EFNA1

    EFNA3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/135 NCBI SNPs in EFNA3 are shown (see all 135    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs37669161,2
    C,F,A,H,--155049402(+) TCCTGC/TAGAGA 1 -- us2k133Minor allele frequency- T:0.24EA NS NA WA CSA 4608
    rs727022691,2
    C,F,--155049414(+) NNNNCC/TGGATT 1 -- us2k12Minor allele frequency- T:0.05WA NA 238
    rs1503969201,2
    --155049583(+) CCAAAC/TCAGCA 1 -- us2k10--------
    rs1819703041,2
    --155049705(+) TTGTGA/GCACCT 1 -- us2k10--------
    rs601575271,2
    C,--155049771(+) CCTGCA/GGGGAG 1 -- us2k12Minor allele frequency- G:0.12WA 120
    rs1381274191,2
    --155049844(+) TGAGAA/GGGAAG 1 -- us2k10--------
    rs1438503331,2
    --155050197(+) TGAACC/GCTTTT 1 -- us2k10--------
    rs1472613371,2
    --155050276(+) GGTTTA/GTGTGT 1 -- us2k10--------
    rs1870623561,2
    --155050502(+) TGAGGA/GCAATG 1 -- us2k10--------
    rs1163450561,2
    F,--155050559(+) GATCAG/ACGTCT 1 -- us2k11Minor allele frequency- A:0.03WA 118

    HapMap Linkage Disequilibrium report for EFNA3 (155036224 - 155060014 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for EFNA3: --

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    EFNA3 for disorders           About GeneDecksing

    OMIM gene information: 601381    OMIM disorders: --

    9 diseases for EFNA3:    About MalaCards
    alopecia    skin cancer    prostate carcinoma    osteosarcoma
    cerebritis    hypoxia    prostatitis    carcinoma
    neuronitis

    1 Novoseek disease relationship for EFNA3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 6.59 2 12209731 (1), 16516143 (1)

    Human Genome Epidemiology (HuGE) Navigator: EFNA3 (1 document)

    Export disorders for EFNA3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EFNA3 gene, integrated from 9 sources (see all 38):
    (articles sorted by number of sources associating them with EFNA3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The genes encoding the eph-related receptor tyrosine kinase ligands LERK-1 (EPLG1, Epl1), LERK-3 (EPLG3, Epl3), and LERK-4 (EPLG4, Epl4) are clustered on human chromosome 1 and mouse chromosome 3. (PubMed id 8660976)1, 3, 9 Cerretti D.P....Morris S.W. (1996)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Ligands for the receptor tyrosine kinases hek and elk: isolation of cDNAs encoding a family of proteins. (PubMed id 7838529)1, 2 Kozlosky C.J.... Beckmann M.P. (1995)
    5. Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity. (PubMed id 7973638)1, 2 Davis S.... Yancopoulos G.D. (1994)
    6. MicroRNA-210 modulates endothelial cell response to hypoxia and inhibits the receptor tyrosine kinase ligand Ephrin-A3. (PubMed id 18417479)1, 9 Fasanaro P....Martelli F. (2008)
    7. A role for the Eph ligand ephrin-A3 in entorhino-hippocampal axon targeting. (PubMed id 10516308)1, 9 Stein E....Skutella T. (1999)
    8. Human dendritic cells express neuronal Eph receptor tyrosine kinases: role of EphA2 in regulating adhesion to fibronectin. (PubMed id 12907451)1, 9 de Saint-Vis B....Garrone P. (2003)
    9. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PubMed id 19204726)1 Chapuis J....Lambert J.C. (2009)
    10. Cytoplasmic relaxation of active Eph controls ephrin shedding by ADAM10. (PubMed id 19823572)1 Janes P.W....Lackmann M. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1944 HGNC: 3223 AceView: EFNA3 Ensembl:ENSG00000143590 euGenes: HUgn1944
    ECgene: EFNA3 Kegg: 1944 H-InvDB: EFNA3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for EFNA3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for EFNA3 gene:
    Search GeneIP for patents involving EFNA3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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