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Aliases for EFNA2 Gene

Aliases for EFNA2 Gene

  • Ephrin-A2 2 3
  • EPLG6 3 4 6
  • LERK6 3 4 6
  • HEK7 Ligand 3 4
  • HEK7-L 3 4
  • LERK-6 3 4
  • Eph-Related Receptor Tyrosine Kinase Ligand 6 3
  • EPH-Related Receptor Tyrosine Kinase Ligand 6 4
  • ELF-1 3

External Ids for EFNA2 Gene

Previous HGNC Symbols for EFNA2 Gene

  • EPLG6

Previous GeneCards Identifiers for EFNA2 Gene

  • GC19P001344
  • GC19P001226
  • GC19P001237
  • GC19P001070

Summaries for EFNA2 Gene

Entrez Gene Summary for EFNA2 Gene

  • This gene encodes a member of the ephrin family. The protein is composed of a signal sequence, a receptor-binding region, a spacer region, and a hydrophobic region. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. Posttranslational modifications determine whether this protein localizes to the nucleus or the cytoplasm. [provided by RefSeq, Jul 2008]

GeneCards Summary for EFNA2 Gene

EFNA2 (Ephrin-A2) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and Ras signaling pathway. GO annotations related to this gene include ephrin receptor binding. An important paralog of this gene is EFNA3.

UniProtKB/Swiss-Prot for EFNA2 Gene

  • Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the EPHA2 receptor may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis (By similarity).

Gene Wiki entry for EFNA2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EFNA2 Gene

Genomics for EFNA2 Gene

Regulatory Elements for EFNA2 Gene

Genomic Location for EFNA2 Gene

Start:
1,286,154 bp from pter
End:
1,301,431 bp from pter
Size:
15,278 bases
Orientation:
Plus strand

Genomic View for EFNA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EFNA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EFNA2 Gene

Proteins for EFNA2 Gene

  • Protein details for EFNA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43921-EFNA2_HUMAN
    Recommended name:
    Ephrin-A2
    Protein Accession:
    O43921
    Secondary Accessions:
    • O76020

    Protein attributes for EFNA2 Gene

    Size:
    213 amino acids
    Molecular mass:
    23878 Da
    Quaternary structure:
    • Binds to the receptor tyrosine kinases EPHA3, EPHA4 and EPHA5. Interacts with EPHA8; activates EPHA8.

    Three dimensional structures from OCA and Proteopedia for EFNA2 Gene

neXtProt entry for EFNA2 Gene

Proteomics data for EFNA2 Gene at MOPED

Post-translational modifications for EFNA2 Gene

  • Glycosylation at Asn42, Asn174, and Asn188
  • Modification sites at PhosphoSitePlus

Other Protein References for EFNA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EFNA2 Gene

Domains for EFNA2 Gene

Gene Families for EFNA2 Gene

HGNC:

Protein Domains for EFNA2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for EFNA2 Gene

Graphical View of Domain Structure for InterPro Entry

O43921

UniProtKB/Swiss-Prot:

EFNA2_HUMAN :
  • O43921
Domain:
  • Contains 1 ephrin RBD (ephrin receptor-binding) domain.
Family:
  • Belongs to the ephrin family.
genes like me logo Genes that share domains with EFNA2: view

Function for EFNA2 Gene

Molecular function for EFNA2 Gene

GENATLAS Biochemistry: ephrin A2,EPH-related receptor tyrosine kinase,class A,ligand expressed in fetal brain and intestin,in adult lung and intestine
UniProtKB/Swiss-Prot Function: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the EPHA2 receptor may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis (By similarity).

Gene Ontology (GO) - Molecular Function for EFNA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0046875 ephrin receptor binding IBA --
genes like me logo Genes that share ontologies with EFNA2: view

Phenotypes for EFNA2 Gene

MGI mutant phenotypes for EFNA2:
inferred from 1 alleles
GenomeRNAi human phenotypes for EFNA2:
genes like me logo Genes that share phenotypes with EFNA2: view

Animal Models for EFNA2 Gene

MGI Knock Outs for EFNA2:

miRNA for EFNA2 Gene

miRTarBase miRNAs that target EFNA2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for EFNA2 Gene

Localization for EFNA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EFNA2 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EFNA2 Gene COMPARTMENTS Subcellular localization image for EFNA2 gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for EFNA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
GO:0031225 anchored component of membrane IEA --
GO:0031594 neuromuscular junction IEA --
genes like me logo Genes that share ontologies with EFNA2: view

Pathways for EFNA2 Gene

genes like me logo Genes that share pathways with EFNA2: view

Gene Ontology (GO) - Biological Process for EFNA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007267 cell-cell signaling TAS 9826538
GO:0007411 axon guidance TAS --
GO:0021772 olfactory bulb development IEA --
GO:0030316 osteoclast differentiation ISS --
GO:0046849 bone remodeling ISS --
genes like me logo Genes that share ontologies with EFNA2: view

Compounds for EFNA2 Gene

(1) Novoseek inferred chemical compound relationships for EFNA2 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 53.8 8
genes like me logo Genes that share compounds with EFNA2: view

Transcripts for EFNA2 Gene

mRNA/cDNA for EFNA2 Gene

(2) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EFNA2 Gene

Ephrin-A2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EFNA2 Gene

No ASD Table

Relevant External Links for EFNA2 Gene

GeneLoc Exon Structure for
EFNA2
ECgene alternative splicing isoforms for
EFNA2

Expression for EFNA2 Gene

mRNA expression in normal human tissues for EFNA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EFNA2 Gene

This gene is overexpressed in Colon - Transverse (15.1), Liver (12.6), and Small Intestine - Terminal Ileum (7.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for EFNA2 Gene

SOURCE GeneReport for Unigene cluster for EFNA2 Gene Hs.741510

genes like me logo Genes that share expressions with EFNA2: view

No data available for mRNA Expression by UniProt/SwissProt for EFNA2 Gene

Orthologs for EFNA2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for EFNA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EFNA2 35
  • 99.6 (n)
  • 100 (a)
EFNA2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EFNA2 35
  • 92.18 (n)
  • 96.24 (a)
EFNA2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Efna2 35
  • 86.12 (n)
  • 90.91 (a)
Efna2 16
Efna2 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EFNA2 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EFNA2 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Efna2 35
  • 85.49 (n)
  • 90.91 (a)
chicken
(Gallus gallus)
Aves EFNA2 35
  • 80.48 (n)
  • 80.66 (a)
lizard
(Anolis carolinensis)
Reptilia EFNA2 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia efna2 35
  • 69.33 (n)
  • 78.86 (a)
zebrafish
(Danio rerio)
Actinopterygii efna2 36
  • 56 (a)
OneToMany
EFNA2 (2 of 2) 36
  • 58 (a)
OneToMany
LOC100332852 35
  • 66.27 (n)
  • 68.05 (a)
Species with no ortholog for EFNA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EFNA2 Gene

ENSEMBL:
Gene Tree for EFNA2 (if available)
TreeFam:
Gene Tree for EFNA2 (if available)

Paralogs for EFNA2 Gene

Paralogs for EFNA2 Gene

Selected SIMAP similar genes for EFNA2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with EFNA2: view

Variants for EFNA2 Gene

Sequence variations from dbSNP and Humsavar for EFNA2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs724421 -- 1,294,200(+) CTAAT(A/T)AGCCC intron-variant
rs1057270 -- 1,299,888(+) CCGGG(C/T)GGCTG reference, synonymous-codon
rs1557831 -- 1,298,902(+) atcac(A/G)ccact intron-variant
rs1974563 -- 1,301,725(+) gggag(G/T)tggag downstream-variant-500B
rs1989952 -- 1,293,357(+) CCGGC(C/T)GGCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EFNA2 Gene

Variant ID Type Subtype PubMed ID
nsv910292 CNV Loss 21882294
dgv3555n71 CNV Loss 21882294
nsv9662 CNV Gain 18304495
dgv1055e1 CNV Complex 17122850
dgv3575n71 CNV Loss 21882294
dgv3580n71 CNV Loss 21882294
nsv470103 CNV Gain 18288195
nsv910420 CNV Loss 21882294
dgv3583n71 CNV Loss 21882294
dgv3586n71 CNV Loss 21882294
nsv470104 CNV Loss 18288195
dgv3587n71 CNV Loss 21882294
nsv910442 CNV Gain+Loss 21882294
dgv3588n71 CNV Loss 21882294
dgv3589n71 CNV Loss 21882294
dgv3591n71 CNV Loss 21882294
dgv3592n71 CNV Loss 21882294
dgv3594n71 CNV Loss 21882294
nsv910471 CNV Loss 21882294
dgv3595n71 CNV Loss 21882294
dgv3596n71 CNV Loss 21882294
nsv910475 CNV Loss 21882294
nsv910476 CNV Loss 21882294

Relevant External Links for EFNA2 Gene

HapMap Linkage Disequilibrium report
EFNA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EFNA2 Gene

Disorders for EFNA2 Gene

(1) University of Copenhagen DISEASES for EFNA2 Gene

(1) Novoseek inferred disease relationships for EFNA2 Gene

Disease -log(P) Hits PubMed IDs
lupus erythematosus systemic 30.2 6
genes like me logo Genes that share disorders with EFNA2: view

No data available for UniProtKB/Swiss-Prot for EFNA2 Gene

Publications for EFNA2 Gene

  1. Cloning, chromosomal mapping, and tissue expression of the gene encoding the human Eph-family kinase ligand ephrin-A2. (PMID: 9826538) Aasheim H.-C. … Logtenberg T. (Biochem. Biophys. Res. Commun. 1998) 3 4 23
  2. Characterization of the genes for mouse LERK-3/Ephrin-A3 (Epl3), mouse LERK-4/Ephrin-A4 (Epl4), and human LERK-6/Ephrin-A2 (EPLG6): conservation of intron/exon structure. (PMID: 9465306) Cerretti D.P. … Nelson N. (Genomics 1998) 3 4 23
  3. Eph receptor-ligand interactions are necessary for guidance of retinal ganglion cell axons in vitro. (PMID: 9751130) Ciossek T. … Drescher U. (Eur. J. Neurosci. 1998) 3 23
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4
  5. Elf-1 binds to GGAA elements on the FcRgamma promoter and represses its expression. (PMID: 17878388) Juang Y.T. … Tsokos G.C. (J. Immunol. 2007) 3 23

Products for EFNA2 Gene

Sources for EFNA2 Gene

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