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EFNA2 Gene

protein-coding   GIFtS: 58
GCID: GC19P001286

Ephrin-A2


(Previous symbol: EPLG6)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ephrin-A21 2     HEK7-L2 3
EPLG61 2 3 5     LERK-62 3
LERK62 3 5     HEK7 Ligand2 3
EPH-Related Receptor Tyrosine Kinase Ligand 62 3     ELF-12

External Ids:    HGNC: 32221   Entrez Gene: 19432   Ensembl: ENSG000000996177   OMIM: 6027565   UniProtKB: O439213   

Export aliases for EFNA2 gene to outside databases

Previous GC identifers: GC19P001344 GC19P001226 GC19P001237 GC19P001070


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for EFNA2 Gene:
This gene encodes a member of the ephrin family. The protein is composed of a signal sequence, a receptor-binding
region, a spacer region, and a hydrophobic region. The EPH and EPH-related receptors comprise the largest
subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events,
particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided
into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and
the ephrin-B (EFNB) class, which are transmembrane proteins. Posttranslational modifications determine whether
this protein localizes to the nucleus or the cytoplasm. (provided by RefSeq, Jul 2008)

GeneCards Summary for EFNA2 Gene:
EFNA2 (ephrin-A2) is a protein-coding gene. Diseases associated with EFNA2 include craniofrontonasal syndrome, and craniosynostosis. GO annotations related to this gene include ephrin receptor binding. An important paralog of this gene is EFNA1.

UniProtKB/Swiss-Prot: EFNA2_HUMAN, O43921
Function: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial
for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously
Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring
cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling
pathway downstream of the ephrin ligand is referred to as reverse signaling. With the EPHA2 receptor may play a
role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis (By similarity)

Gene Wiki entry for EFNA2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the EFNA2 gene promoter:
         GR   p53   AP-1   ATF-2   Sox9   Chx10   c-Jun   GR-alpha   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEFNA2 promoter sequence
   Search Chromatin IP Primers for EFNA2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EFNA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13

EFNA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EFNA2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P001286:  view genomic region     (about GC identifiers)

Start:
1,286,153 bp from pter      End:
1,301,430 bp from pter
Size:
15,278 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: EFNA2_HUMAN, O43921 (See protein sequence)
Recommended Name: Ephrin-A2 precursor  
Size: 213 amino acids; 23878 Da
Subunit: Binds to the receptor tyrosine kinases EPHA3, EPHA4 and EPHA5. Interacts with EPHA8; activates EPHA8
1 PDB 3D structure from and Proteopedia for EFNA2:
2WO3 (3D)    
Secondary accessions: O76020

Explore the universe of human proteins at neXtProt for EFNA2: NX_O43921

Explore proteomics data for EFNA2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn42, Asn174, Asn188

  • See EFNA2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001396.2  
    ENSEMBL proteins: 
     ENSP00000215368  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    EFN: Ephrins

    3 InterPro protein domains:
     IPR001799 Ephrin
     IPR008972 Cupredoxin
     IPR019765 Ephrin_CS

    Graphical View of Domain Structure for InterPro Entry O43921

    ProtoNet protein and cluster: O43921

    1 Blocks protein domain: IPB001799 Ephrin signature

    UniProtKB/Swiss-Prot: EFNA2_HUMAN, O43921
    Similarity: Belongs to the ephrin family
    Similarity: Contains 1 ephrin RBD (ephrin receptor-binding) domain


    EFNA2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EFNA2_HUMAN, O43921
    Function: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial
    for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously
    Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring
    cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling
    pathway downstream of the ephrin ligand is referred to as reverse signaling. With the EPHA2 receptor may play a
    role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis (By similarity)

         Genatlas biochemistry entry for EFNA2:
    ephrin A2,EPH-related receptor tyrosine kinase,class A,ligand expressed in fetal brain and intestin,in adult lung
    and intestine

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0046875ephrin receptor binding IBA--
         
    EFNA2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for EFNA2:
     Increased cell death HMECs cel 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Efna2):
     cellular  nervous system 

    EFNA2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Efna2tm1Jgf for EFNA2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EFNA2
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EFNA2

    miRNA
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    miRTarBase miRNAs that target EFNA2:
    hsa-mir-26b-5p (MIRT029892), hsa-mir-335-5p (MIRT018404)

    Block miRNA regulation of human, mouse, rat EFNA2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EFNA2 (see all 20):
    hsa-miR-137 hsa-miR-3660 hsa-miR-128 hsa-miR-219-5p hsa-miR-374a hsa-miR-340 hsa-miR-410 hsa-miR-508-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EFNA2_HUMAN, O43921: Cell membrane; Lipid-anchor, GPI-anchor (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular3
    cytoskeleton1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IBA--
    GO:0016020membrane ----
    GO:0031225anchored component of membrane IEA--
    GO:0031594neuromuscular junction IEA--
    GO:0043204perikaryon IEA--

    EFNA2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for EFNA2 About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1Ras signaling pathway
    Rap1 signaling pathway0.36
    Ras signaling pathway0.36
    2EphB-EphrinB Signaling
    Ephrin-Eph Signaling0.58
    3Development Slit Robo signaling
    Neurophysiological process Receptor mediated axon growth repulsion0.41
    4EPHB forward signaling
    Cell adhesion Ephrins signaling0.30
    5PI3K-Akt signaling pathway
    PI3K-Akt signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for EFNA2
        Guidance Cues and Growth Cone Motility
    Ephrin-Eph Signaling
    EphrinA-EphR Signaling

    3 GeneGo (Thomson Reuters) Pathways for EFNA2
        Neurophysiological process Receptor-mediated axon growth repulsion
    G-protein signaling RhoA regulation pathway
    Cell adhesion Ephrins signaling

    1 BioSystems Pathway for EFNA2
        EPHA forward signaling



    4 Kegg Pathways  (Kegg details for EFNA2):
        Ras signaling pathway
    Rap1 signaling pathway
    PI3K-Akt signaling pathway
    Axon guidance


    EFNA2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for EFNA2
    Interactions:

        GeneGlobe Interaction Network for EFNA2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for EFNA2 (O439212, 3 ENSP000002153684) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EPHA2P293173, ENSP000003512094I2D: score=2 STRING: ENSP00000351209
    EPHA7Q153753, ENSP000003583094I2D: score=2 STRING: ENSP00000358309
    EPHA6Q9UF333, ENSP000003743234I2D: score=1 STRING: ENSP00000374323
    ZHX1Q9UKY13, ENSP000002978574I2D: score=1 STRING: ENSP00000297857
    EPHA4P547643, ENSP000002818214I2D: score=1 STRING: ENSP00000281821
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007267cell-cell signaling TAS9826538
    GO:0007411axon guidance IBA--
    GO:0021772olfactory bulb development IEA--
    GO:0030316osteoclast differentiation ISS--
    GO:0046849bone remodeling ISS--

    EFNA2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EFNA2

    1 Novoseek inferred chemical compound relationship for EFNA2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 53.8 8 9010230 (2), 9751130 (1), 15021900 (1), 11397000 (1) (see all 7)



    EFNA2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for EFNA2 gene: 
    NM_001405.3  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000215368(uc002lry.2)
    miRNA
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    hsa-miR-137 hsa-miR-3660 hsa-miR-128 hsa-miR-219-5p hsa-miR-374a hsa-miR-340 hsa-miR-410 hsa-miR-508-3p
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      QuantiTect SYBR Green Assays in human, mouse, rat EFNA2
      QuantiFast Probe-based Assays in human, mouse, rat EFNA2

    2 AceView cDNA sequences:

    NM_001405 AJ007292 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EFNA2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCAACGGCG
    EFNA2 Expression
    About this image


    EFNA2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Thalamus
     
     Neural Tube (Nervous System)
             Diencephalon
    EFNA2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EFNA2 Protein Expression
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for EFNA2 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Efna21 , 5 ephrin A21, 5 86.12(n)1
    90.91(a)1
      10 (39.72 cM)5
    136371  NM_007909.31  NP_031935.31 
     801794825 
    chicken
    (Gallus gallus)
    Aves EFNA21 ephrin-A2 80.48(n)
    80.66(a)
      395831  NM_204983.1  NP_990314.1 
    lizard
    (Anolis carolinensis)
    Reptilia EFNA26
    ephrin-A2
    82(a)
    1 ↔ 1
    AAWZ02037638(9937-10239)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia efna21 ephrin-A2 69.33(n)
    78.86(a)
      100144647  NM_001123420.1  NP_001116892.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003328521 ephrin-A2-like 66.27(n)
    68.05(a)
      100332852  XM_002663727.3  XP_002663773.1 


    ENSEMBL Gene Tree for EFNA2 (if available)
    TreeFam Gene Tree for EFNA2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for EFNA2 gene
    EFNA12  EFNA52  EFNA32  EFNA42  ENSG000002512462  
    4 SIMAP similar genes for EFNA2 using alignment to 2 protein entries:     EFNA2_HUMAN (see all proteins):
    EFNA5    EFNA3    EFNA4    EFNA1

    EFNA2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for EFNA2 (see all 334)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs37609881,2
    C,F,H--1284173(+) CCAGAC/TGGAGC 1 -- us2k110Minor allele frequency- T:0.01EA NS NA 1188
    rs1383826601,2
    --1284324(+) CTGAAA/GAGACA 1 -- us2k10--------
    rs744474041,2
    C,F--1284332(+) ACACCC/TGGCCA 1 -- us2k11Minor allele frequency- T:0.05WA 118
    rs1155184751,2
    F--1284350(+) GCCTTC/TGACCT 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs37609891,2
    C,H--1284470(+) CACTGG/CGTGGG 1 -- us2k14Minor allele frequency- C:0.00NS EA 414
    rs1461517281,2
    --1284573(+) GGCCCC/GCGTGG 1 -- us2k10--------
    rs1927398761,2
    C--1284593(+) GAATCA/GGGGGA 1 -- us2k10--------
    rs1483055201,2
    --1284602(+) GAGGAA/GGGCAC 1 -- us2k10--------
    rs1414050471,2
    --1284786(+) GGTGCA/TTGCCC 1 -- us2k10--------
    rs1119240471,2
    C,F--1284843(+) GAGACG/ATACAA 1 -- us2k11Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for EFNA2 (1286153 - 1301430 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for EFNA2 (see all 23):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3589n71CNV Loss21882294
    nsv910476CNV Loss21882294
    dgv3586n71CNV Loss21882294
    nsv910292CNV Loss21882294
    nsv910471CNV Loss21882294
    dgv3591n71CNV Loss21882294
    dgv3595n71CNV Loss21882294
    dgv3555n71CNV Loss21882294
    dgv3575n71CNV Loss21882294
    dgv3596n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602756    OMIM disorders: --

    12 diseases for EFNA2:    
    About MalaCards
    craniofrontonasal syndrome    craniosynostosis    lupus erythematosus    systemic lupus erythematosus
    endometrial carcinoma    atherosclerosis    retinitis    cerebritis
    endotheliitis    neuronitis    breast cancer    leukemia

    1 disease from the University of Copenhagen DISEASES database for EFNA2:
    Craniofrontonasal syndrome

    EFNA2 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for EFNA2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lupus erythematosus systemic 30.2 6 12727645 (2), 12421992 (1), 18714041 (1), 17878388 (1) (see all 5)


    Export disorders for EFNA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EFNA2 gene, integrated from 10 sources (see all 87):
    (articles sorted by number of sources associating them with EFNA2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the genes for mouse LERK-3/Ephrin-A3 (Epl3), mouse LERK-4/Ephrin-A4 (Epl4), and human LERK-6/Ephrin-A2 (EPLG6): conservation of intron/exon structure. (PubMed id 9465306)1, 2, 9 Cerretti D.P. and Nelson N. (Genomics 1998)
    2. Cloning, chromosomal mapping, and tissue expression of the gene encoding the human Eph-family kinase ligand ephrin-A2. (PubMed id 9826538)1, 2, 9 Aasheim H.-C.... Logtenberg T. (Biochem. Biophys. Res. Commun. 1998)
    3. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    4. Defective production of functional 98-kDa form of Elf-1 is responsible for the decreased expression of TCR zeta-chain in patients with systemic lupus erythematosus. (PubMed id 12421992)1, 9 Juang Y.T....Tsokos G.C. (J. Immunol. 2002)
    5. Elf-1 binds to GGAA elements on the FcRgamma promoter and represses its expression. (PubMed id 17878388)1, 9 Juang Y.T....Tsokos G.C. (J. Immunol. 2007)
    6. Regulated cleavage of a contact-mediated axon repellent. (PubMed id 10958785)1, 9 Hattori M....Flanagan J.G. (Science 2000)
    7. Eph receptor-ligand interactions are necessary for guidance of retinal ganglion cell axons in vitro. (PubMed id 9751130)1, 9 Ciossek T....Drescher U. (Eur. J. Neurosci. 1998)
    8. EphA2 activation promotes the endothelial cell inflammatory response: a potential role in atherosclerosis. (PubMed id 22247258)1 Funk S.D....Orr A.W. (Arterioscler. Thromb. Vasc. Biol. 2012)
    9. The ephrin A1-EphA2 system promotes cardiac stem cell migration after infarction. (PubMed id 21415392)1 Goichberg P....Leri A. (Circ. Res. 2011)
    10. The ubiquitin carboxyl hydrolase BAP1 forms a ternary complex with YY1 and HCF-1 and is a critical regulator of gene expression. (PubMed id 20805357)1 Yu H....Affar e.l. .B. (Mol. Cell. Biol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
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      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1943 HGNC: 3222 AceView: EFNA2 Ensembl:ENSG00000099617 euGenes: HUgn1943
    ECgene: EFNA2 Kegg: 1943 H-InvDB: EFNA2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for EFNA2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EFNA2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for EFNA2 gene:
    Search GeneIP for patents involving EFNA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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