Aliases for EFL1 Gene
External Ids for EFL1 Gene
Previous HGNC Symbols for EFL1 Gene
GeneCards Summary for EFL1 Gene
UniProtKB/Swiss-Prot for EFL1 Gene
Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Has low intrinsic GTPase activity. GTPase activity is increased by contact with 60S ribosome subunits.