EFEMP2 Gene
protein-coding GIFtS: 63
GCID: GC11M065633
|
|
EGF containing fibulin-like extracellular matrix protein...(Previous name: EGF-containing fibulin-like extracellular matrix protein...)
| |
Aliases
for EFEMP2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| EGF Containing Fibulin-Like Extracellular Matrix Protein 21 2 | | MBP12 | | FBLN41 2 3 5 | | Fibulin 42 | | UPH11 2 5 | | Fibulin-43 | | EGF-Containing Fibulin-Like Extracellular Matrix Protein 21 2 | | Mutant P53 Binding Protein 12 | | FIBL-42 3 | | Fibulin-43 | | ARCL1B2 | | Protein UPH13 |
| External Ids: | HGNC: 32191 | Entrez Gene: 300082 | Ensembl: ENSG000001726387 | OMIM: 6046335 | UniProtKB: O959673 |
|---|
| | ORGUL members: | |
|---|
| NONCODE:n410551 | |
Export aliases for EFEMP2 gene to outside databasesPrevious GC identifers: GC11M068168 GC11M067315 GC11M065884 GC11M065409 GC11M065390 GC11M061960
Summaries
for EFEMP2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for EFEMP2:
A large number of extracellular matrix proteins have been found to contain variations of the epidermal growth factor(EGF) domain and have been implicated in functions as diverse as blood coagulation, activation of complement anddetermination of cell fate during development. The protein encoded by this gene contains four EGF2 domains and sixcalcium-binding EGF2 domains. This gene is necessary for elastic fiber formation and connective tissue development.Defects in this gene are cause of an autosomal recessive cutis laxa syndrome. Alternatively spliced transcriptvariants have been identified for this gene. (provided by RefSeq, Jan 2011)
Gene Wiki entry for EFEMP2
|
Genomic Views
for EFEMP2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the EFEMP2 gene promoter:
NF-1 p53 ATF-2 IRF-1 Roaz Arnt PPAR-alpha FAC1 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for EFEMP2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EFEMP2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13.1 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q13EFEMP2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M065633: view genomic region
(about GC identifiers)
Start:
|
65,633,912 bp from pter |
End:
|
65,641,063 bp from pter |
Size:
|
7,152 bases |
Orientation:
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minus strand |
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Proteins
for EFEMP2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FBLN4_HUMAN, O95967 (See
protein sequence)Recommended Name: EGF-containing fibulin-like extracellular matrix protein 2 precursor Size: 443 amino acids; 49405 Da
Subcellular location: Secreted
1 PDB 3D structure from  and Proteopedia  for EFEMP2:2KL7 (3D)
Secondary accessions: A8K7R4 B3KM31 B3KQT1 O75967Explore the universe of human proteins at neXtProt for EFEMP2: NX_O95967
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O95967
EFEMP2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_058634.4
ENSEMBL proteins: ENSP00000431305 ENSP00000435295 ENSP00000436536 ENSP00000436521 ENSP00000434151 ENSP00000309953 ENSP00000432191 ENSP00000436526 ENSP00000435823 ENSP00000435419 ENSP00000435963 ENSP00000437238 Reactome Protein details: O95967
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
EFEMP2 for ontologies About GeneDecksing
EFEMP2 Antibody Products:
Assay Products for EFEMP2: |
Protein
Domains /
Families
for EFEMP2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
EFEMP2 for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry O95967ProtoNet protein and cluster: O95967 2 Blocks protein families: IPB000152 Aspartic acid and asparagine hydroxylation site IPB001881 EGF-like calcium-binding
UniProtKB/Swiss-Prot: FBLN4_HUMAN, O95967Similarity: Belongs to the fibulin familySimilarity: Contains 6 EGF-like domains |
Function
for EFEMP2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
Genatlas biochemistry entry for EFEMP2:EGF-containing fibrillin-like extracellular matrix protein 2,expressed in both fetal and adult retina in fetalbrain,kidney and heart,EFEMP1 paralog
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EFEMP2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EFEMP2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: EFEMP2 (NM_016938) | |  | Sino Biological Human cDNA Clone for EFEMP2 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EFEMP2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EFEMP2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EFEMP2 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
EFEMP2 for ontologies About GeneDecksing
Animal Models:
Mouse knock-outs for EFEMP2: Efemp2tm1.2Hiya Efemp2tm1.2Tynk
6 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for Efemp2):
EFEMP2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for EFEMP2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Integrin Pathway | | | 2 | Rho Family GTPases | | | 3 | Elastic fibre formation | | | 4 | PTEN Pathway | | | 5 | Collagen formation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/13 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for EFEMP2 (see all 13)
3 
Reactome Pathways for EFEMP2
EFEMP2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for EFEMP2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/64 Interacting proteins for EFEMP2 (O959671, 2, 3 ENSP000003099534) via UniProtKB, MINT, STRING, and/or I2D (see all 64)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| ATN1 | P542591, 2, 3, ENSP000003490764 | EBI-743414,EBI-945980 MINT-2872547 MINT-2872528 MINT-2872566 I2D:
score=2 STRING: ENSP00000349076 | | RHOXF2 | Q9BQY41, 2, 3, ENSP000003604414 | EBI-743414,EBI-372094 MINT-68138 I2D:
score=5 STRING: ENSP00000360441 | | GFI1B | Q5VTD92, 3, ENSP000003447824 | MINT-2872623 MINT-2872642 I2D:
score=2 STRING: ENSP00000344782 | | RERE | Q9P2R62, 3, ENSP000003386294 | MINT-2872661 MINT-2872680 I2D:
score=2 STRING: ENSP00000338629 | | APEX2 | Q9UBZ42, 3, ENSP000003641264 | MINT-67353 I2D:
score=4 STRING: ENSP00000364126 |
About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007596 | blood coagulation |
IEA | -- |
EFEMP2 for ontologies About GeneDecksing
|
Drugs & Compounds
for EFEMP2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for EFEMP2
Search CenterWatch for drugs/clinical trials and news about EFEMP2 / FBLN4
|
Transcripts
for EFEMP2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for EFEMP2 gene: NM_016938.4 Unigene Cluster for EFEMP2: EGF containing fibulin-like extracellular matrix protein 2 Hs.731454 [show with all ESTs]Unigene Representative Sequence: AB20912118/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20): ENST00000527277 ENST00000531972 ENST00000526628 ENST00000526911 ENST00000531645
ENST00000528176 ENST00000307998(uc001ofz.3 uc001ofy.4) ENST00000524408
ENST00000532648 ENST00000528409 ENST00000530806 ENST00000525392 ENST00000532084
ENST00000531005 ENST00000527969 ENST00000533347 ENST00000526624 ENST00000527378
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EFEMP2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EFEMP2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: EFEMP2 (NM_016938) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EFEMP2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EFEMP2 |
Additional cDNA sequence: AB030655.1 AB209121.1 AF093119.1 AF124486.1 AJ132819.2 AK075453.1 AK292079.1 AK315181.1 AY358899.1 BC010456.1 BC109225.1 CR541934.1 NR_037718.1 20 DOTS entries: DT.100808616 DT.453509 DT.95185436 DT.91764438 DT.95334444 DT.100808628 DT.100802942 DT.100039510 DT.40189820 DT.100035545 DT.100039512 DT.120690256 DT.100735419 DT.120690083 DT.100061044 DT.99964054 DT.120690049 DT.120690120 DT.120690259 DT.95072621 24/2886 AceView cDNA sequences (see all 2886): CA306290 CA433624 BI258761 AL545946 CR601037 CR624160 BC012265 BM783265 BM846066 BU730497 AA477258 BM973725 BM455139 BM552944 N75449 BU631334 BM556564 CB127486 BM988917 BM480297 AI085632 CA310112 BM920982 AA252249
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for EFEMP2 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 |
|---|
|
| SP1: | | | | | | | - | | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | - | | | | |
| SP2: | | | | | | | - | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for EFEMP2
|
Expression
for EFEMP2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| EFEMP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCTACCGGG
About this image
See EFEMP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for EFEMP2
SOURCE GeneReport for Unigene cluster: Hs.731454
SABiosciences Custom PCR Arrays for EFEMP2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EFEMP2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EFEMP2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EFEMP2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EFEMP2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EFEMP2 |
Orthologs
for EFEMP2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for EFEMP2 gene from 5/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
EFEMP26 |
-- |
72(a) |
1 ↔ 1 |
AAWZ02036837(713-14085) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.163722 |
Transcribed sequence with moderate similarity to protein more |
74.55(n) |
|
BX722983.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufb22f102 |
Transcribed sequence with moderate similarity to protein more |
75.44(n) |
|
57039315 |
fruit fly
(Drosophila melanogaster) |
Insecta |
frac6 |
faulty attraction |
7(a) |
1 → many |
3L(7555710-7562599) |
worm
(Caenorhabditis elegans) |
Secernentea |
mup-46mua-36 |
Transmembrane cell adhesion receptor mua-3 |
4(a)2(a) |
possible orthologpossible ortholog |
III(7479616-7489010) III(10160599-10183440) |
ENSEMBL Gene Tree for EFEMP2 (if available)
TreeFam Gene Tree for EFEMP2 (if available) |
Paralogs
for EFEMP2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for EFEMP2 gene
- FBN12 LTBP32 SCUBE32 FBN32 FBLN52 FBN22 LTBP42 EFEMP12
- SCUBE12 LTBP22 LTBP12 FBLN22 FBLN12 SCUBE22
14 SIMAP similar genes for EFEMP2 using alignment to 12 protein entries: FBLN4_HUMAN (see all proteins):MBP1 LDLR EFEMP1 FBLN5 FBLN2 PROS1
NPNT DKFZp586A1519 FBLN1 DKFZp667O055 FBLN7 SCUBE2
EMR2 FBN1
EFEMP2 for paralogs About GeneDecksing
|
Genomic Variants
for EFEMP2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for EFEMP2 (65633912 - 65641063 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for EFEMP2
1 CNV: 3855
Human Gene Mutation Database (HGMD): EFEMP2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EFEMP2 |
|
Disorders
/ Diseases
for EFEMP2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
EFEMP2 for disorders About GeneDecksing
OMIM gene information: 604633
OMIM disorders: 219100
UniProtKB/Swiss-Prot: FBLN4_HUMAN, O95967
Defects in EFEMP2 are the cause of cutis laxa, autosomal recessive, type 1B (ARCL1B) [MIM:614437]. Aconnective tissue disorder characterized by characterized by loose, hyperextensible skin with decreased resilience andelasticity leading to a premature aged appearance. Face, hands, feet, joints, and torso may be differentiallyaffected. The clinical spectrum of autosomal recessive cutis laxa is highly heterogeneous with respect to organinvolvement and severity. ARCL1B features include emphysema, lethal pulmonary artery occlusion, aortic aneurysm,cardiopulmonary insufficiency, birth fractures, arachnodactyly, and fragility of blood vessels
15  diseases for EFEMP2: About MalaCardscutis laxa doyne honeycomb retinal dystrophy contractural arachnodactyly rectal prolapse
dengue hemorrhagic fever hemorrhagic fever fundus dystrophy aortic aneurysm
macular degeneration retinitis osteoarthritis pharyngitis
prostate cancer ataxia prostatitis
1 disease from the University of Copenhagen DISEASES database for EFEMP2:Cutis laxa Human Genome Epidemiology (HuGE) Navigator: EFEMP2 (2 documents)
Export disorders for EFEMP2 gene to outside databases
|
Publications
for EFEMP2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for EFEMP2 gene, integrated from 9 sources (see all 35):
(articles sorted by number of sources associating them with EFEMP2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Sequence, recombinant expression and tissue localization of two novel extracellular matrix proteins, fibulin-3 and fibulin-4. (PubMed id 10601734)1, 2, 3, 9 Giltay R.... Kostka G. (1999)
- Isolation of a paralog of the Doyne honeycomb retinal dystrophy gene from the multiple retinopathy critical region on 11q13. (PubMed id 10982184)1, 2, 3, 9 Katsanis N....Lupski J.R. (2000)
- Fibulin-4: a novel gene for an autosomal recessive cutis laxa syndrome. (PubMed id 16685658)1, 2, 9 Hucthagowder V....Urban Z. (2006)
- Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)1, 2 Taylor T.D....Sakaki Y. (2006)
- Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Fibulin-4 regulates expression of the tropoelastin ge ne and consequent elastic-fibre formation by human fibroblasts. (PubMed id 19627254)1, 9 Chen Q....Dicorleto P.E. (2009)
- Fibulin-4 is a target of autoimmunity predominantly in patients with osteoarthritis. (PubMed id 16493080)1, 9 Xiang Y....Kato T. (2006)
|
External Searches for EFEMP2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing EFEMP2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing EFEMP2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing EFEMP2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for EFEMP2 | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/EFEMP2 |
|
| | |
About This Section
| Patent Information for EFEMP2 gene:
Search GeneIP for patents involving EFEMP2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for EFEMP2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for EFEMP2 | | OriGene shRNA RFP for EFEMP2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EFEMP2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EFEMP2 | | | OriGene Protein Over-expression Lysate for EFEMP2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for EFEMP2 | | OriGene 3'-UTR Clone for EFEMP2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EFEMP2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EFEMP2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for EFEMP2 | | OriGene Custom Protein Services for EFEMP2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat EFEMP2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EFEMP2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EFEMP2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EFEMP2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EFEMP2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EFEMP2 |
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| | | | Search Tocris compounds for EFEMP2 |
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 | | | EFEMP2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EFEMP2 |
|  |  |  | | | | ThermoFisher Antibody for EFEMP2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EFEMP2 |
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