Aliases for EFEMP1 Gene
Aliases for EFEMP1 Gene
External Ids for EFEMP1 Gene
- HGNC: 3218
- Entrez Gene: 2202
- Ensembl: ENSG00000115380
- OMIM: 601548
- UniProtKB: Q12805
Previous HGNC Symbols for EFEMP1 Gene
- DHRD
- FBNL
Previous GeneCards Identifiers for EFEMP1 Gene
- GC02M056130
- GC02M056279
- GC02M056067
- GC02M056004
- GC02M056093
Summaries for EFEMP1 Gene
-
This gene encodes a member of the fibulin family of extracellular matrix glycoproteins. Like all members of this family, the encoded protein contains tandemly repeated epidermal growth factor-like repeats followed by a C-terminus fibulin-type domain. This gene is upregulated in malignant gliomas and may play a role in the aggressive nature of these tumors. Mutations in this gene are associated with Doyne honeycomb retinal dystrophy. Alternatively spliced transcript variants that encode the same protein have been described.[provided by RefSeq, Nov 2009]
GeneCards Summary for EFEMP1 Gene
EFEMP1 (EGF Containing Fibulin Like Extracellular Matrix Protein 1) is a Protein Coding gene. Diseases associated with EFEMP1 include Doyne Honeycomb Degeneration Of Retina and Familial Drusen. Among its related pathways are Phospholipase-C Pathway and ERK Signaling. GO annotations related to this gene include calcium ion binding and epidermal growth factor receptor binding. An important paralog of this gene is EFEMP2.
UniProtKB/Swiss-Prot for EFEMP1 Gene
-
Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EFEMP1 Gene
Genomics for EFEMP1 Gene
Regulatory Elements for EFEMP1 Gene
Enhancers for EFEMP1 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around EFEMP1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the EFEMP1 gene promoter:
Regulatory Element Products
Genomic Location for EFEMP1 Gene
- Chromosome:
- 2
- Start:
- 55,865,962 bp from pter
- End:
- 55,924,163 bp from pter
- Size:
- 58,202 bases
- Orientation:
- Minus strand
Genomic View for EFEMP1 Gene
Genes around EFEMP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2p16.1 by Ensembl
- 2p16.1 by Entrez Gene
- 2p16.1 by HGNC
EFEMP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for EFEMP1 Gene
Proteins for EFEMP1 Gene
-
Protein details for EFEMP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q12805-FBLN3_HUMAN
- Recommended name:
- EGF-containing fibulin-like extracellular matrix protein 1
- Protein Accession:
- Q12805
- A8K3I4
- B4DW75
- D6W5D2
- Q541U7
Protein attributes for EFEMP1 Gene
- Size:
- 493 amino acids
- Molecular mass:
- 54641 Da
- Quaternary structure:
-
- Interacts with ECM1. Interacts with TIMP3.
- Miscellaneous:
-
- Up-regulated in malignant gliomas. May increase glioma cell adhesiveness and invasive properties.
Protein Expression for EFEMP1 Gene
Post-translational modifications for EFEMP1 Gene
Other Protein References for EFEMP1 Gene
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for EFEMP1
- R&D Systems Antibodies for EFEMP1 (Fibulin 3)
- Novus Biologicals Antibodies for EFEMP1
-
Cloud-Clone Corp. Antibodies for EFEMP1
- Invitrogen Antibodies for EFEMP1
- antibodies-online Antibodies for EFEMP1: See all 83
- GeneTex EFEMP1 antibody for EFEMP1
-
Custom Antibody ServicesProSci Antibodies for EFEMP1
-
Santa Cruz Biotechnology (SCBT) Antibodies for EFEMP1
Protein Products
- R&D Systems Proteins and Enzymes for EFEMP1 (Fibulin 3)
-
OriGene Purified Proteins for EFEMP1
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- Origene Custom Protein Services for EFEMP1
-
Cloud-Clone Corp. Proteins for EFEMP1
- antibodies-online Proteins for EFEMP1: See all 14
- Search antibodies-online for peptides
- Search GeneTex for Proteins for EFEMP1
Assay Products
- antibodies-online Kits for EFEMP1: See all 11
No data available for DME Specific Peptides for EFEMP1 Gene
Domains & Families for EFEMP1 Gene
Gene Families for EFEMP1 Gene
- HGNC:
Protein Domains for EFEMP1 Gene
Suggested Antigen Peptide Sequences for EFEMP1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q12805- Family:
-
- Belongs to the fibulin family.
Function for EFEMP1 Gene
Molecular function for EFEMP1 Gene
- GENATLAS Biochemistry:
- EGF-containing fibrillin-like extracellular matrix protein 1,expressed in retina and retina pigment epithelium,overexpressed in senescent or quiescent fibroblasts
- UniProtKB/Swiss-Prot Function:
- Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005006 | epidermal growth factor-activated receptor activity | IDA | 19804359 |
| GO:0005154 | epidermal growth factor receptor binding | IDA | 19804359 |
| GO:0005509 | calcium ion binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 12620389 |
| GO:0008083 | growth factor activity | IEA | -- |
Phenotypes for EFEMP1 Gene
- MGI mutant phenotypes for EFEMP1:
-
inferred from 5 alleles
- mortality/aging
- behavior/neurological phenotype
- normal phenotype
- growth/size/body region phenotype
- immune system phenotype
- muscle phenotype
- homeostasis/metabolism phenotype
- cardiovascular system phenotype
- digestive/alimentary phenotype
- reproductive system phenotype
- endocrine/exocrine gland phenotype
- vision/eye phenotype
- integument phenotype
- skeleton phenotype
- pigmentation phenotype
- hematopoietic system phenotype
- renal/urinary system phenotype
- liver/biliary system phenotype
- adipose tissue phenotype
- GenomeRNAi human phenotypes for EFEMP1:
Animal Models for EFEMP1 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for EFEMP1
- Cyagen custom Knockout/knockin (KOKI) mouse models for EFEMP1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for EFEMP1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for EFEMP1 gene
- Search ViGene Biosciences for EFEMP1
CRISPR Products
-
OriGene CRISPR knockouts for EFEMP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for EFEMP1
- GenScript: Design CRISPR guide RNA sequences for EFEMP1
miRNA Products
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Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for EFEMP1
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-
ViGene Biosciences ready-to-package AAV shRNAs for EFEMP1 gene
Clone Products
- Sino Biological Human cDNA Clone for EFEMP1
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- Addgene plasmids for EFEMP1
- VectorBuilder custom plasmid, inducible vectors for EFEMP1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for EFEMP1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for EFEMP1
-
ViGene Biosciences adenoviral particle packaged cDNA for EFEMP1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for EFEMP1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for EFEMP1 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for EFEMP1 Gene
Localization for EFEMP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for EFEMP1 Gene
- Secreted, extracellular space. Secreted, extracellular space, extracellular matrix. Note=Localizes to the lamina propria underneath the olfactory epithelium. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005578 | proteinaceous extracellular matrix | TAS,IEA | -- |
| GO:0005615 | extracellular space | IEA,IDA | 16502470 |
| GO:0031012 | colocalizes_with extracellular matrix | IEA,IDA | 20551380 |
| GO:0070062 | extracellular exosome | IDA | 23376485 |
Pathways & Interactions for EFEMP1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Integrin Pathway |
.67
.67
.56
|
.56
|
| 2 | ERK Signaling |
.61
.58
|
.49
|
| 3 | Phospholipase-C Pathway |
.56
|
|
| 4 | Elastic fibre formation | ||
| 5 | Degradation of the extracellular matrix | ||
Pathways by source for EFEMP1 Gene
3 Reactome pathways for EFEMP1 Gene
13 Qiagen pathways for EFEMP1 Gene
Interacting Proteins for EFEMP1 Gene
Selected Interacting proteins:
Q12805-FBLN3_HUMAN
ENSP00000347596
for EFEMP1 Gene via
IID
STRING
MINT
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-templated | IDA | 20005202 |
| GO:0007173 | epidermal growth factor receptor signaling pathway | IDA,IEA | 19804359 |
| GO:0007601 | visual perception | TAS | 10369267 |
| GO:0018108 | peptidyl-tyrosine phosphorylation | IDA | 19804359 |
| GO:0032331 | negative regulation of chondrocyte differentiation | IDA | 20005202 |
No data available for SIGNOR curated interactions for EFEMP1 Gene
Transcripts for EFEMP1 Gene
mRNA/cDNA for EFEMP1 Gene
- (5) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (447) Selected AceView cDNA sequences:
- (14) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for EFEMP1 Gene
- EGF containing fibulin-like extracellular matrix protein 1:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for EFEMP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for EFEMP1
- GenScript: Design CRISPR guide RNA sequences for EFEMP1
miRNA Products
- Search ViGene Biosciences for EFEMP1
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for EFEMP1
- Browse OriGene Inhibitory RNA Products For EFEMP1
-
ViGene Biosciences ready-to-package AAV shRNAs for EFEMP1 gene
Clone Products
- Sino Biological Human cDNA Clone for EFEMP1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for EFEMP1
- VectorBuilder custom plasmid, inducible vectors for EFEMP1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for EFEMP1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP9: | - |
Expression for EFEMP1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Kidney (Urinary System)
- Metanephric Mesenchyme Cells Metanephric Mesenchyme
- Renal Collecting Duct System
- S-shaped Body
-
Eye (Sensory Organs)
- GABAergic Amacrine Cells Inner Nuclear Layer
- Retina
- Brain (Nervous System)
- Endothelium (Cardiovascular System)
-
Neurons
- GABAergic Amacrine Cells Inner Nuclear Layer
-
Epidermis (Integumentary System)
- Basal Keratinocytes Embryonic Epidermis
-
Epithelial Cells
- Basal Keratinocytes Embryonic Epidermis
-
Hair
- Basal Keratinocytes Embryonic Epidermis
- Bone (Muscoskeletal System)
- Adipose (Muscoskeletal System)
- Dermis (Integumentary System)
- Fibroblasts
- NULL (Uncategorized)
- Neural Tube (Nervous System)
-
Umbilical Cord (Extraembryonic Tissues)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Smooth Muscle (Muscoskeletal System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Ovary (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for EFEMP1 Gene
This gene is overexpressed in Artery - Aorta (x9.3) and Artery - Coronary (x5.9).
This gene is overexpressed in Vitreous humor (18.5), Cerebrospinal fluid (6.9), Synovial fluid (6.2), Urine (6.1), and Skin (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EFEMP1 Gene
NURSA nuclear receptor signaling pathways regulating expression of EFEMP1 Gene:
EFEMP1SOURCE GeneReport for Unigene cluster for EFEMP1 Gene:
Hs.76224mRNA Expression by UniProt/SwissProt for EFEMP1 Gene:
Q12805-FBLN3_HUMAN
Tissue specificity:
In the eye, associated with photoreceptor outer and inner segment regions, the nerve fiber layer, outer nuclear layer and inner and outer plexiform layers of the retina.
Evidence on tissue expression from TISSUES for EFEMP1 Gene
- Lung(4.8)
- Nervous system(4.5)
- Skin(4.4)
- Liver(4.2)
- Eye(3.1)
- Heart(2.9)
- Gall bladder(2.1)
- Muscle(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for EFEMP1 Gene
Germ Layers:
- ectoderm
Systems:
- nervous
Organs:
Head and neck:
- brain
- cranial nerve
- eye
- head
General:
- peripheral nervous system
Primer Products
-
OriGene qPCR primer pairs and template standards for EFEMP1
-
OriGene qPCR primer pairs for EFEMP1
Orthologs for EFEMP1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | EFEMP1 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | EFEMP1 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | EFEMP1 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | EFEMP1 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | EFEMP1 35 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Efemp1 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Efemp1 34 |
|
||
| chicken (Gallus gallus) |
Aves | EFEMP1 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | EFEMP1 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | efemp1 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | EFEMP1 (1 of 2) 35 |
|
OneToMany | |
| LOC100332567 34 |
|
||||
| EFEMP1 (2 of 2) 35 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | CG31999 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | fbl-1 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for EFEMP1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for EFEMP1 Gene
Paralogs for EFEMP1 Gene
(19) SIMAP similar genes for EFEMP1 Gene using alignment to 10 proteins:
Variants for EFEMP1 Gene
| SNP ID | Clin | Chr 02 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs121434491 | Pathogenic, Doyne honeycomb retinal dystrophy (DHRD) [MIM:126600] | 55,871,091(-) | AATGC(C/T)GGGAG | reference, missense | |
| rs138843899 | Likely benign | 55,866,386(+) | TCTCA(A/G)TAGTA | utr-variant-3-prime | |
| rs143361440 | Likely benign | 55,923,750(+) | CGAGG(A/G)GAGTG | reference, synonymous-codon, utr-variant-5-prime | |
| rs146101049 | Likely benign | 55,866,273(+) | CTTGT(A/G)GAAGT | utr-variant-3-prime | |
| rs146446706 | Likely benign | 55,870,880(+) | GTTCT(C/T)GGCAC | reference, missense |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3307790 | CNV | mobile element insertion | 20981092 |
| esv3392665 | CNV | insertion | 20981092 |
| esv3575244 | CNV | gain | 25503493 |
| esv3583831 | CNV | loss | 25503493 |
| esv3892437 | CNV | loss | 25118596 |
| nsv2736 | CNV | insertion | 18451855 |
| nsv819764 | CNV | loss | 19587683 |
Residual Variation Intolerance Score:
17.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.31;
26.02% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for EFEMP1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EFEMP1 Gene
Disorders for EFEMP1 Gene
(11) MalaCards diseases for EFEMP1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| doyne honeycomb degeneration of retina |
|
|
| familial drusen |
|
|
| pleural cancer |
|
|
| retinal drusen |
|
|
| wolfram syndrome |
|
|
Search EFEMP1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
FBLN3_HUMAN- Doyne honeycomb retinal dystrophy (DHRD) [MIM:126600]: Autosomal dominant disease characterized by yellow-white deposits known as drusen that accumulate beneath the retinal pigment epithelium. {ECO:0000269 PubMed:10369267, ECO:0000269 PubMed:11384588, ECO:0000269 PubMed:12242346, ECO:0000269 PubMed:17666404}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Relevant External Links for EFEMP1
No data available for Genatlas for EFEMP1 Gene
Publications for EFEMP1 Gene
- EFEMP1 is not associated with sporadic early onset drusen. (PMID: 11262647) Sauer C.G. … Weber B.H. (Ophthalmic Genet. 2001) 3 4 22 46 64
- Structure and chromosomal assignment of the human S1-5 gene (FBNL) that is highly homologous to fibrillin. (PMID: 8812496) Ikegawa S. … Nakamura Y. (Genomics 1996) 2 3 4 22 64
- ECM1 interacts with fibulin-3 and the beta 3 chain of laminin 332 through its serum albumin subdomain-like 2 domain. (PMID: 19275936) Sercu S. … Merregaert J. (Matrix Biol. 2009) 3 4 22 64
- EFEMP1 binds the EGF receptor and activates MAPK and Akt pathways in pancreatic carcinoma cells. (PMID: 19804359) Camaj P. … Bruns C.J. (Biol. Chem. 2009) 3 4 22 64
- Fibulin-3 is uniquely upregulated in malignant gliomas and promotes tumor cell motility and invasion. (PMID: 19887559) Hu B. … Viapiano M.S. (Mol. Cancer Res. 2009) 3 4 22 64
Products for EFEMP1 Gene
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- Cloud-Clone Corp. Proteins for EFEMP1
- Taconic Biosciences Mouse Models for EFEMP1
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Addgene plasmids for EFEMP1
- antibodies-online Antibodies for EFEMP1: See all 83
- antibodies-online Kits for EFEMP1: See all 11
- antibodies-online Proteins for EFEMP1: See all 14
- Search antibodies-online for peptides
- GeneTex EFEMP1 antibody for EFEMP1
- Search GeneTex for Proteins for EFEMP1
- ViGene Biosciences adenoviral particle packaged cDNA for EFEMP1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for EFEMP1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for EFEMP1 gene
- Search ViGene Biosciences for EFEMP1
- Santa Cruz Biotechnology (SCBT) Antibodies for EFEMP1
- Search Santa Cruz Biotechnology (SCBT) for EFEMP1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for EFEMP1
- Custom Antibody ServicesProSci Antibodies for EFEMP1
- Search for EFEMP1 Proteins at ProSci
- Horizon Cell Lines for EFEMP1
- Cyagen custom Knockout/knockin (KOKI) mouse models for EFEMP1
- VectorBuilder custom plasmid, inducible vectors for EFEMP1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for EFEMP1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for EFEMP1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer