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Aliases for EFCAB8 Gene

Aliases for EFCAB8 Gene

  • EF-Hand Calcium Binding Domain 8 2 3 5

External Ids for EFCAB8 Gene

Previous GeneCards Identifiers for EFCAB8 Gene

  • GC20P030908
  • GC20P031446
  • GC20P028234

Summaries for EFCAB8 Gene

GeneCards Summary for EFCAB8 Gene

EFCAB8 (EF-Hand Calcium Binding Domain 8) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is WDR64.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EFCAB8 Gene

Genomics for EFCAB8 Gene

Regulatory Elements for EFCAB8 Gene

Enhancers for EFCAB8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G032902 0.9 ENCODE 10.9 +43.7 43747 0.2 ARID4B ZNF48 RAD21 ZNF121 GLIS2 ZNF143 PCBP1 MIXL1 DEK ZNF654 BPIFB4 SUN5 EFCAB8 BPIFA3 ENSG00000224876 PIR55937
GH20G033277 1 ENCODE 9.6 +419.3 419311 1.7 ATF1 FOXA2 MLX ARID4B ZNF48 SLC30A9 SP5 MXD4 PPARG KAT8 BPIFA1 ENSG00000224876 BPIFA3 BPIFA2 SUN5 EFCAB8 BPIFB1 PIR39691
GH20G033076 0.9 ENCODE 10.2 +218.0 218007 0.2 FOXA2 MLX DMAP1 RAD21 ZSCAN9 GLIS2 GATA4 FOS PCBP1 ZNF654 SUN5 BPIFA1 EFCAB8 BPIFA2 BPIFB4 BPIFB3
GH20G032894 0.8 ENCODE 11.2 +35.3 35347 0.2 ELF3 CTCF RB1 SAP130 ZIC2 ZNF48 RAD21 TEAD3 GLIS2 ZBTB48 MAPRE1 EFCAB8 BPIFB4 ENSG00000260257 PIR55937
GH20G032807 0.7 ENCODE 11.6 -50.9 -50926 1.8 ZBTB21 KLF17 ZIC2 ZEB1 ZNF366 POLR2A ZBTB48 PATZ1 PRDM10 MAZ EFCAB8 BPIFB4 BPIFA3 ENSG00000224876 ENSG00000260257 COMMD7 GC20P032809 DNMT3B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EFCAB8 on UCSC Golden Path with GeneCards custom track

Genomic Location for EFCAB8 Gene

Chromosome:
20
Start:
32,858,923 bp from pter
End:
32,961,845 bp from pter
Size:
102,923 bases
Orientation:
Plus strand

Genomic View for EFCAB8 Gene

Genes around EFCAB8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EFCAB8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EFCAB8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EFCAB8 Gene

Proteins for EFCAB8 Gene

  • Protein details for EFCAB8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MWE9-EFCB8_HUMAN
    Recommended name:
    EF-hand calcium-binding domain-containing protein 8
    Protein Accession:
    A8MWE9

    Protein attributes for EFCAB8 Gene

    Size:
    144 amino acids
    Molecular mass:
    16428 Da
    Quaternary structure:
    No Data Available

neXtProt entry for EFCAB8 Gene

Post-translational modifications for EFCAB8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EFCAB8 Gene

No data available for DME Specific Peptides for EFCAB8 Gene

Domains & Families for EFCAB8 Gene

Protein Domains for EFCAB8 Gene

Suggested Antigen Peptide Sequences for EFCAB8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with EFCAB8: view

No data available for UniProtKB/Swiss-Prot for EFCAB8 Gene

Function for EFCAB8 Gene

Gene Ontology (GO) - Molecular Function for EFCAB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with EFCAB8: view

Animal Model Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for EFCAB8 Gene

Localization for EFCAB8 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EFCAB8 gene
Compartment Confidence
nucleus 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for EFCAB8 Gene

Pathways & Interactions for EFCAB8 Gene

SuperPathways for EFCAB8 Gene

No Data Available

Interacting Proteins for EFCAB8 Gene

Gene Ontology (GO) - Biological Process for EFCAB8 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for EFCAB8 Gene

Drugs & Compounds for EFCAB8 Gene

No Compound Related Data Available

Transcripts for EFCAB8 Gene

mRNA/cDNA for EFCAB8 Gene

(3) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for EFCAB8 Gene

No ASD Table

Relevant External Links for EFCAB8 Gene

GeneLoc Exon Structure for
EFCAB8
ECgene alternative splicing isoforms for
EFCAB8

Expression for EFCAB8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EFCAB8 Gene

mRNA differential expression in normal tissues according to GTEx for EFCAB8 Gene

This gene is overexpressed in Testis (x19.0) and Whole Blood (x9.1).

Protein differential expression in normal tissues from HIPED for EFCAB8 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for EFCAB8 Gene



Protein tissue co-expression partners for EFCAB8 Gene

NURSA nuclear receptor signaling pathways regulating expression of EFCAB8 Gene:

EFCAB8
genes like me logo Genes that share expression patterns with EFCAB8: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for EFCAB8 Gene

Orthologs for EFCAB8 Gene

This gene was present in the common ancestor of animals.

Orthologs for EFCAB8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EFCAB8 35
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MGC151671 35
  • 11 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Efcab8 35
  • 6 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 4 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 3 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia EFCAB8 35
  • 1 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EFCAB8 35
  • 10 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG40583 35
  • 5 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 9 (a)
OneToMany
Species where no ortholog for EFCAB8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for EFCAB8 Gene

ENSEMBL:
Gene Tree for EFCAB8 (if available)
TreeFam:
Gene Tree for EFCAB8 (if available)

Paralogs for EFCAB8 Gene

Paralogs for EFCAB8 Gene

genes like me logo Genes that share paralogs with EFCAB8: view

Variants for EFCAB8 Gene

Sequence variations from dbSNP and Humsavar for EFCAB8 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000007475 -- 32,900,891(+) TAGAG(A/T)TGGGG intron-variant
rs1000022421 -- 32,949,377(+) CCAAT(C/G)AATAT intron-variant
rs1000027549 -- 32,925,706(+) GGGAA(C/G)GACCA intron-variant
rs1000038437 -- 32,949,869(+) GCGGT(A/G)CCTGC intron-variant
rs1000064053 -- 32,904,836(+) TGGCC(A/G)GGCTG intron-variant

Variation tolerance for EFCAB8 Gene

Gene Damage Index Score: 7.81; 83.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EFCAB8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EFCAB8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for EFCAB8 Gene

Disorders for EFCAB8 Gene

Relevant External Links for EFCAB8

Genetic Association Database (GAD)
EFCAB8

No disorders were found for EFCAB8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EFCAB8 Gene

Publications for EFCAB8 Gene

  1. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64

Products for EFCAB8 Gene

Sources for EFCAB8 Gene

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