Aliases for EFCAB6 Gene
External Ids for EFCAB6 Gene
Previous GeneCards Identifiers for EFCAB6 Gene
This gene encodes a protein which directly binds the oncogene DJ-1 and androgen receptor to form a ternary complex in cells. This binding protein recruits histone-deacetylase complexes in order to repress transcription activity of androgen receptor. This protein may also play a role in spermatogenesis and fertilization. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
GeneCards Summary for EFCAB6 Gene
EFCAB6 (EF-Hand Calcium Binding Domain 6) is a Protein Coding gene. Among its related pathways are Androgen receptor signaling pathway. GO annotations related to this gene include calcium ion binding.
UniProtKB/Swiss-Prot for EFCAB6 Gene
Negatively regulates the androgen receptor by recruiting histone deacetylase complex, and protein DJ-1 antagonizes this inhibition by abrogation of this complex.