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Aliases for EFCAB2 Gene

Aliases for EFCAB2 Gene

  • EF-Hand Calcium Binding Domain 2 2 3 5
  • Dynein Regulatory Complex Subunit 8 2 3
  • CFAP200 3
  • DRC8 3

External Ids for EFCAB2 Gene

Previous GeneCards Identifiers for EFCAB2 Gene

  • GC01P241460
  • GC01P243199
  • GC01P245133
  • GC01P215516

Summaries for EFCAB2 Gene

Entrez Gene Summary for EFCAB2 Gene

  • The gene encodes a protein that contains two EF-hand calcium-binding domains although its function has yet to be determined. Alternatively spliced transcripts have been observed. [provided by RefSeq, Mar 2014]

GeneCards Summary for EFCAB2 Gene

EFCAB2 (EF-Hand Calcium Binding Domain 2) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CETN2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EFCAB2 Gene

Genomics for EFCAB2 Gene

Regulatory Elements for EFCAB2 Gene

Enhancers for EFCAB2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around EFCAB2 on UCSC Golden Path with GeneCards custom track

Promoters for EFCAB2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EFCAB2 on UCSC Golden Path with GeneCards custom track

Genomic Location for EFCAB2 Gene

244,969,705 bp from pter
245,127,164 bp from pter
157,460 bases
Plus strand

Genomic View for EFCAB2 Gene

Genes around EFCAB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EFCAB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EFCAB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EFCAB2 Gene

Proteins for EFCAB2 Gene

  • Protein details for EFCAB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    EF-hand calcium-binding domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • B4DZE9
    • Q59G23
    • Q9BS36

    Protein attributes for EFCAB2 Gene

    269 amino acids
    Molecular mass:
    29714 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for EFCAB2 Gene


neXtProt entry for EFCAB2 Gene

Proteomics data for EFCAB2 Gene at MOPED

Post-translational modifications for EFCAB2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for EFCAB2 Gene

Domains & Families for EFCAB2 Gene

Protein Domains for EFCAB2 Gene


Graphical View of Domain Structure for InterPro Entry



  • Contains 2 EF-hand domains.
  • Contains 2 EF-hand domains.
genes like me logo Genes that share domains with EFCAB2: view

Function for EFCAB2 Gene

genes like me logo Genes that share phenotypes with EFCAB2: view

Animal Model Products

miRNA for EFCAB2 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EFCAB2 Gene

Localization for EFCAB2 Gene

Subcellular locations from

Jensen Localization Image for EFCAB2 Gene COMPARTMENTS Subcellular localization image for EFCAB2 gene
Compartment Confidence
cytosol 4
mitochondrion 2
nucleus 2
peroxisome 2
plasma membrane 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for EFCAB2 Gene

Pathways & Interactions for EFCAB2 Gene

SuperPathways for EFCAB2 Gene

No Data Available

Interacting Proteins for EFCAB2 Gene

Gene Ontology (GO) - Biological Process for EFCAB2 Gene


No data available for Pathways by source and SIGNOR curated interactions for EFCAB2 Gene

Drugs & Compounds for EFCAB2 Gene

No Compound Related Data Available

Transcripts for EFCAB2 Gene

Unigene Clusters for EFCAB2 Gene

EF-hand calcium binding domain 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EFCAB2 Gene

No ASD Table

Relevant External Links for EFCAB2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EFCAB2 Gene

mRNA expression in normal human tissues for EFCAB2 Gene

Protein differential expression in normal tissues from HIPED for EFCAB2 Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EFCAB2 Gene

SOURCE GeneReport for Unigene cluster for EFCAB2 Gene Hs.134857

genes like me logo Genes that share expression patterns with EFCAB2: view

Protein tissue co-expression partners for EFCAB2 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EFCAB2 Gene

Orthologs for EFCAB2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EFCAB2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia EFCAB2 35
  • 91.15 (n)
  • 91.98 (a)
  • 91 (a)
(Canis familiaris)
Mammalia EFCAB2 35
  • 87.88 (n)
  • 87.01 (a)
  • 88 (a)
(Mus musculus)
Mammalia Efcab2 35
  • 86.42 (n)
  • 85.8 (a)
Efcab2 16
Efcab2 36
  • 85 (a)
(Pan troglodytes)
Mammalia EFCAB2 35
  • 99.38 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Efcab2 35
  • 87.25 (n)
  • 88.97 (a)
(Monodelphis domestica)
Mammalia EFCAB2 36
  • 36 (a)
(Ornithorhynchus anatinus)
Mammalia EFCAB2 36
  • 67 (a)
(Gallus gallus)
Aves EFCAB2 35
  • 74.49 (n)
  • 68.52 (a)
  • 66 (a)
(Anolis carolinensis)
Reptilia EFCAB2 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia efcab2 35
  • 73.91 (n)
  • 74.53 (a)
(Danio rerio)
Actinopterygii efcab2 35
  • 66.05 (n)
  • 67.08 (a)
efcab2 36
  • 64 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1428 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006174 35
  • 50.91 (n)
  • 44.52 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11041 36
  • 44 (a)
CG13526 36
  • 23 (a)
CG9406 36
  • 32 (a)
Eip63F-1 36
  • 23 (a)
TpnC25D 36
  • 21 (a)
TpnC4 36
  • 20 (a)
TpnC41C 36
  • 23 (a)
TpnC47D 36
  • 21 (a)
TpnC73F 36
  • 21 (a)
(Caenorhabditis elegans)
Secernentea cal-5 36
  • 22 (a)
E02A10.3 36
  • 16 (a)
tnc-2 36
  • 21 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC31 36
  • 25 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13955 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11218 36
  • 65 (a)
Species with no ortholog for EFCAB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EFCAB2 Gene

Gene Tree for EFCAB2 (if available)
Gene Tree for EFCAB2 (if available)

Paralogs for EFCAB2 Gene

Paralogs for EFCAB2 Gene

(12) SIMAP similar genes for EFCAB2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with EFCAB2: view

Variants for EFCAB2 Gene

Sequence variations from dbSNP and Humsavar for EFCAB2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2945 -- 245,091,720(-) ATGTT(A/G)TGCTT intron-variant
rs2946 -- 245,091,709(-) TCTGG(G/T)GGCCT intron-variant
rs471747 -- 245,059,205(-) AAAGA(A/T)GAAAG intron-variant
rs479597 -- 244,999,383(-) AGGGA(A/G)ACAGG intron-variant
rs483290 -- 244,999,017(-) ATCCT(A/T)TTTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EFCAB2 Gene

Variant ID Type Subtype PubMed ID
esv22057 CNV Loss 19812545
nsv873395 CNV Gain 21882294
nsv5188 CNV Insertion 18451855
esv2726729 CNV Deletion 23290073
esv2726740 CNV Deletion 23290073
nsv827664 CNV Loss 20364138
esv2669322 CNV Deletion 23128226
esv269284 CNV Insertion 20981092
esv273990 CNV Insertion 20981092
esv2663617 CNV Deletion 23128226
esv2673217 CNV Deletion 23128226
esv2726751 CNV Deletion 23290073
esv24561 CNV Loss 19812545
esv2726762 CNV Deletion 23290073

Variation tolerance for EFCAB2 Gene

Residual Variation Intolerance Score: 53.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.70; 86.50% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for EFCAB2 Gene

Disorders for EFCAB2 Gene

Relevant External Links for EFCAB2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for EFCAB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EFCAB2 Gene

Publications for EFCAB2 Gene

  1. The N-DRC forms a conserved biochemical complex that maintains outer doublet alignment and limits microtubule sliding in motile axonemes. (PMID: 23427265) Bower R. … Porter M.E. (Mol. Biol. Cell 2013) 2 3 67
  2. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y. … Ge F. (Mol. Cell Proteomics 2013) 3
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3

Products for EFCAB2 Gene

Sources for EFCAB2 Gene