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Aliases for EFCAB14 Gene

Aliases for EFCAB14 Gene

  • EF-Hand Calcium Binding Domain 14 2 3 5
  • KIAA0494 2 3 4

External Ids for EFCAB14 Gene

Previous HGNC Symbols for EFCAB14 Gene

  • KIAA0494

Previous GeneCards Identifiers for EFCAB14 Gene

  • GC01M047125

Summaries for EFCAB14 Gene

GeneCards Summary for EFCAB14 Gene

EFCAB14 (EF-Hand Calcium Binding Domain 14) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EFCAB14 Gene

Genomics for EFCAB14 Gene

Regulatory Elements for EFCAB14 Gene

Promoters for EFCAB14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EFCAB14 on UCSC Golden Path with GeneCards custom track

Genomic Location for EFCAB14 Gene

Chromosome:
1
Start:
46,675,159 bp from pter
End:
46,719,064 bp from pter
Size:
43,906 bases
Orientation:
Minus strand

Genomic View for EFCAB14 Gene

Genes around EFCAB14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EFCAB14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EFCAB14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EFCAB14 Gene

Proteins for EFCAB14 Gene

  • Protein details for EFCAB14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75071-EFC14_HUMAN
    Recommended name:
    EF-hand calcium-binding domain-containing protein 14
    Protein Accession:
    O75071
    Secondary Accessions:
    • D3DQ23
    • Q5SXB8

    Protein attributes for EFCAB14 Gene

    Size:
    495 amino acids
    Molecular mass:
    55031 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA32328.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for EFCAB14 Gene

Proteomics data for EFCAB14 Gene at MOPED

Post-translational modifications for EFCAB14 Gene

  • Glycosylation at Asn 301 and Ser 412
  • Modification sites at PhosphoSitePlus

Other Protein References for EFCAB14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EFCAB14 Gene

Domains & Families for EFCAB14 Gene

Gene Families for EFCAB14 Gene

Protein Domains for EFCAB14 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for EFCAB14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75071

UniProtKB/Swiss-Prot:

EFC14_HUMAN :
  • Contains 2 EF-hand domains.
Domain:
  • Contains 2 EF-hand domains.
genes like me logo Genes that share domains with EFCAB14: view

Function for EFCAB14 Gene

genes like me logo Genes that share phenotypes with EFCAB14: view

Animal Model Products

CRISPR Products

miRNA for EFCAB14 Gene

miRTarBase miRNAs that target EFCAB14

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EFCAB14 Gene

Localization for EFCAB14 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for EFCAB14 Gene

Pathways & Interactions for EFCAB14 Gene

SuperPathways for EFCAB14 Gene

No Data Available

Interacting Proteins for EFCAB14 Gene

Gene Ontology (GO) - Biological Process for EFCAB14 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for EFCAB14 Gene

Drugs & Compounds for EFCAB14 Gene

No Compound Related Data Available

Transcripts for EFCAB14 Gene

Unigene Clusters for EFCAB14 Gene

EF-hand calcium binding domain 14:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EFCAB14 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1:
SP2: -

Relevant External Links for EFCAB14 Gene

GeneLoc Exon Structure for
EFCAB14
ECgene alternative splicing isoforms for
EFCAB14

Expression for EFCAB14 Gene

mRNA expression in normal human tissues for EFCAB14 Gene

Protein differential expression in normal tissues from HIPED for EFCAB14 Gene

This gene is overexpressed in Adipocyte (58.1) and Testis (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EFCAB14 Gene



SOURCE GeneReport for Unigene cluster for EFCAB14 Gene Hs.707688

genes like me logo Genes that share expression patterns with EFCAB14: view

Protein tissue co-expression partners for EFCAB14 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EFCAB14 Gene

Orthologs for EFCAB14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for EFCAB14 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EFCAB14 35
  • 89.14 (n)
  • 86.84 (a)
EFCAB14 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EFCAB14 35
  • 90.08 (n)
  • 87.45 (a)
EFCAB14 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Efcab14 35
  • 85.58 (n)
  • 81.37 (a)
Efcab14 16
Efcab14 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EFCAB14 35
  • 99.66 (n)
  • 99.39 (a)
EFCAB14 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Efcab14 35
  • 85.95 (n)
  • 84.3 (a)
oppossum
(Monodelphis domestica)
Mammalia EFCAB14 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EFCAB14 36
  • 46 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIAA0494 35
  • 65.21 (n)
  • 59.29 (a)
KIAA0494 36
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EFCAB14 36
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia efcab14 35
  • 61.49 (n)
  • 56.62 (a)
Str.5946 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.22643 35
zebrafish
(Danio rerio)
Actinopterygii zgc:77197 35
  • 58.21 (n)
  • 56.59 (a)
Species with no ortholog for EFCAB14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EFCAB14 Gene

ENSEMBL:
Gene Tree for EFCAB14 (if available)
TreeFam:
Gene Tree for EFCAB14 (if available)

Paralogs for EFCAB14 Gene

Pseudogenes.org Pseudogenes for EFCAB14 Gene

genes like me logo Genes that share paralogs with EFCAB14: view

No data available for Paralogs for EFCAB14 Gene

Variants for EFCAB14 Gene

Sequence variations from dbSNP and Humsavar for EFCAB14 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_048669 -
VAR_074176 -
rs8851 -- 46,718,897(-) TCGGT(C/G)GGCCG utr-variant-5-prime
rs893954 -- 46,702,565(-) AGGAG(A/G)TGTTC intron-variant
rs1371834 -- 46,711,222(-) TGTTT(C/T)TACTG intron-variant

Variation tolerance for EFCAB14 Gene

Residual Variation Intolerance Score: 50.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.24; 52.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EFCAB14 Gene

HapMap Linkage Disequilibrium report
EFCAB14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for EFCAB14 Gene

Disorders for EFCAB14 Gene

Relevant External Links for EFCAB14

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EFCAB14

No disorders were found for EFCAB14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EFCAB14 Gene

Publications for EFCAB14 Gene

  1. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PMID: 9455484) Seki N. … Ohara O. (DNA Res. 1997) 2 3 4 67
  2. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PMID: 23455922) Varjosalo M. … Superti-Furga G. (Nat. Methods 2013) 3
  5. Serum ferritin levels are associated with a distinct phenotype of chronic hepatitis C poorly responding to pegylated interferon-alpha and ribavirin therapy. (PMID: 22095909) Lange C.M. … Bochud P.Y. (Hepatology 2012) 3

Products for EFCAB14 Gene

Sources for EFCAB14 Gene

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