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Aliases for EFCAB14 Gene

Aliases for EFCAB14 Gene

  • EF-Hand Calcium Binding Domain 14 2 3
  • KIAA0494 2 3 4
  • EF-Hand Calcium-Binding Domain-Containing Protein 14 3

External Ids for EFCAB14 Gene

Previous Symbols for EFCAB14 Gene

  • KIAA0494

Summaries for EFCAB14 Gene

GeneCards Summary for EFCAB14 Gene

EFCAB14 (EF-Hand Calcium Binding Domain 14) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EFCAB14 Gene

Genomics for EFCAB14 Gene

Genomic Location for EFCAB14 Gene

Start:
46,675,159 bp from pter
End:
46,719,064 bp from pter
Size:
43,906 bases
Orientation:
Minus strand

Genomic View for EFCAB14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EFCAB14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EFCAB14 Gene

No data available for Regulatory Elements for EFCAB14 Gene

Proteins for EFCAB14 Gene

  • Protein details for EFCAB14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75071-EFC14_HUMAN
    Recommended name:
    EF-hand calcium-binding domain-containing protein 14
    Protein Accession:
    O75071
    Secondary Accessions:
    • D3DQ23
    • Q5SXB8

    Protein attributes for EFCAB14 Gene

    Size:
    495 amino acids
    Molecular mass:
    55031 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA32328.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for EFCAB14 Gene

Proteomics data for EFCAB14 Gene at MOPED

Post-translational modifications for EFCAB14 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn296, Asn301, and Ser412

Other Protein References for EFCAB14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EFCAB14 Gene

Domains for EFCAB14 Gene

Gene Families for EFCAB14 Gene

HGNC:
  • EFHAND :EF-hand domain containing

Protein Domains for EFCAB14 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

EFC14_HUMAN
Domain:
  • Contains 2 EF-hand domains.:
    • O75071
genes like me logo Genes that share domains with EFCAB14: view

Function for EFCAB14 Gene

Gene Ontology (GO) - Molecular Function for EFCAB14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with EFCAB14: view

Phenotypes for EFCAB14 Gene

GenomeRNAi human phenotypes for EFCAB14:
genes like me logo Genes that share phenotypes with EFCAB14: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for EFCAB14 Gene

Localization for EFCAB14 Gene

No data available for Gene Ontology (GO) - Cellular Components for EFCAB14 Gene

Pathways for EFCAB14 Gene

SuperPathways for EFCAB14 Gene

No Data Available

Interacting Proteins for EFCAB14 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000361001%0d%0a9606.ENSP00000217244%0d%0a9606.ENSP00000385269%0d%0a9606.ENSP00000262506%0d%0a
Selected Interacting proteins: ENSP00000361001 for EFCAB14 Gene via STRING

Gene Ontology (GO) - Biological Process for EFCAB14 Gene

None

No data available for Pathways by source for EFCAB14 Gene

Transcripts for EFCAB14 Gene

Unigene Clusters for EFCAB14 Gene

EF-hand calcium binding domain 14:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EFCAB14 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1:
SP2: -

Relevant External Links for EFCAB14 Gene

GeneLoc Exon Structure for
EFCAB14
ECgene alternative splicing isoforms for
EFCAB14

Expression for EFCAB14 Gene

mRNA expression in normal human tissues for EFCAB14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EFCAB14 Gene

SOURCE GeneReport for Unigene cluster for EFCAB14 Gene Hs.707688

genes like me logo Genes that share expressions with EFCAB14: view

Orthologs for EFCAB14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for EFCAB14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EFCAB14 36
  • 99.66 (n)
  • 99.39 (a)
EFCAB14 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EFCAB14 36
  • 89.14 (n)
  • 86.84 (a)
EFCAB14 37
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EFCAB14 36
  • 90.08 (n)
  • 87.45 (a)
EFCAB14 37
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Efcab14 36
  • 85.58 (n)
  • 81.37 (a)
Efcab14 16
Efcab14 37
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EFCAB14 37
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EFCAB14 37
  • 46 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Efcab14 36
  • 85.95 (n)
  • 84.3 (a)
chicken
(Gallus gallus)
Aves KIAA0494 36
  • 65.21 (n)
  • 59.29 (a)
KIAA0494 37
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EFCAB14 37
  • 52 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.22643 36
tropical clawed frog
(Silurana tropicalis)
Amphibia efcab14 36
  • 61.49 (n)
  • 56.62 (a)
Str.5946 36
zebrafish
(Danio rerio)
Actinopterygii zgc:77197 36
  • 58.21 (n)
  • 56.59 (a)
Species with no ortholog for EFCAB14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EFCAB14 Gene

ENSEMBL:
Gene Tree for EFCAB14 (if available)
TreeFam:
Gene Tree for EFCAB14 (if available)

Paralogs for EFCAB14 Gene

Pseudogenes.org Pseudogenes for EFCAB14 Gene

genes like me logo Genes that share paralogs with EFCAB14: view

No data available for Paralogs for EFCAB14 Gene

Variants for EFCAB14 Gene

Sequence variations from dbSNP and Humsavar for EFCAB14 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs8851 -- 46,718,897(-) TCGGT(C/G)GGCCG utr-variant-5-prime
rs893954 -- 46,702,565(-) AGGAG(A/G)TGTTC intron-variant
rs1371834 -- 46,711,222(-) TGTTT(C/T)TACTG intron-variant
rs1440484 -- 46,706,680(-) AAAAG(G/T)ATGGG intron-variant
rs1440485 -- 46,701,606(-) TGCCA(A/G)CCAGT intron-variant

Relevant External Links for EFCAB14 Gene

HapMap Linkage Disequilibrium report
EFCAB14

No data available for Structural Variations from Database of Genomic Variants (DGV) for EFCAB14 Gene

Disorders for EFCAB14 Gene

No disorders were found for EFCAB14 Gene.

No data available for UniProtKB/Swiss-Prot for EFCAB14 Gene

Publications for EFCAB14 Gene

  1. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PMID: 9455484) Seki N. … Ohara O. (DNA Res. 1997) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns. (PMID: 17672918) Szafranski K. … Platzer M. (Genome Biol. 2007) 3
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  5. Serum ferritin levels are associated with a distinct phenotype of chronic hepatitis C poorly responding to pegylated interferon-alpha and ribavirin therapy. (PMID: 22095909) Lange C.M. … Bochud P.Y. (Hepatology 2012) 3

Products for EFCAB14 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate EFCAB14
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for EFCAB14
    • Block miRNA regulation of EFCAB14 using miScript Target Protectors

    Sources for EFCAB14 Gene

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