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Aliases for EFCAB13 Gene

Aliases for EFCAB13 Gene

  • EF-Hand Calcium Binding Domain 13 2 3 5
  • C17orf57 3 4
  • EF-Hand Domain-Containing Protein C17orf57 3
  • Chromosome 17 Open Reading Frame 57 2

External Ids for EFCAB13 Gene

Previous HGNC Symbols for EFCAB13 Gene

  • C17orf57

Previous GeneCards Identifiers for EFCAB13 Gene

  • GC17P045404

Summaries for EFCAB13 Gene

GeneCards Summary for EFCAB13 Gene

EFCAB13 (EF-Hand Calcium Binding Domain 13) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EFCAB13 Gene

Genomics for EFCAB13 Gene

Regulatory Elements for EFCAB13 Gene

Enhancers for EFCAB13 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around EFCAB13 on UCSC Golden Path with GeneCards custom track

Promoters for EFCAB13 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EFCAB13 on UCSC Golden Path with GeneCards custom track

Genomic Location for EFCAB13 Gene

47,323,290 bp from pter
47,441,312 bp from pter
118,023 bases
Plus strand

Genomic View for EFCAB13 Gene

Genes around EFCAB13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EFCAB13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EFCAB13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EFCAB13 Gene

Proteins for EFCAB13 Gene

  • Protein details for EFCAB13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    EF-hand calcium-binding domain-containing protein 13
    Protein Accession:
    Secondary Accessions:
    • G3V128
    • Q49AG9

    Protein attributes for EFCAB13 Gene

    973 amino acids
    Molecular mass:
    110129 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH37876.1; Type=Frameshift; Positions=342; Evidence={ECO:0000305};

    Alternative splice isoforms for EFCAB13 Gene


neXtProt entry for EFCAB13 Gene

Proteomics data for EFCAB13 Gene at MOPED

Post-translational modifications for EFCAB13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EFCAB13 Gene

No data available for DME Specific Peptides for EFCAB13 Gene

Domains & Families for EFCAB13 Gene

Gene Families for EFCAB13 Gene

Protein Domains for EFCAB13 Gene


Suggested Antigen Peptide Sequences for EFCAB13 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 6 EF-hand domains.
  • Contains 6 EF-hand domains.
genes like me logo Genes that share domains with EFCAB13: view

Function for EFCAB13 Gene

genes like me logo Genes that share phenotypes with EFCAB13: view

Animal Model Products

CRISPR Products

miRNA for EFCAB13 Gene

miRTarBase miRNAs that target EFCAB13

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EFCAB13 Gene

Localization for EFCAB13 Gene

Subcellular locations from

Jensen Localization Image for EFCAB13 Gene COMPARTMENTS Subcellular localization image for EFCAB13 gene
Compartment Confidence
nucleus 5
cytosol 3
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for EFCAB13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with EFCAB13: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for EFCAB13 Gene

Pathways & Interactions for EFCAB13 Gene

SuperPathways for EFCAB13 Gene

No Data Available

Interacting Proteins for EFCAB13 Gene

Gene Ontology (GO) - Biological Process for EFCAB13 Gene


No data available for Pathways by source and SIGNOR curated interactions for EFCAB13 Gene

Drugs & Compounds for EFCAB13 Gene

No Compound Related Data Available

Transcripts for EFCAB13 Gene

Unigene Clusters for EFCAB13 Gene

EF-hand calcium binding domain 13:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EFCAB13 Gene

No ASD Table

Relevant External Links for EFCAB13 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EFCAB13 Gene

mRNA expression in normal human tissues for EFCAB13 Gene

mRNA differential expression in normal tissues according to GTEx for EFCAB13 Gene

This gene is overexpressed in Testis (x4.5) and Thyroid (x4.2).

Protein differential expression in normal tissues from HIPED for EFCAB13 Gene

This gene is overexpressed in Gallbladder (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for EFCAB13 Gene

SOURCE GeneReport for Unigene cluster for EFCAB13 Gene Hs.463303

genes like me logo Genes that share expression patterns with EFCAB13: view

Protein tissue co-expression partners for EFCAB13 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for EFCAB13 Gene

Orthologs for EFCAB13 Gene

This gene was present in the common ancestor of chordates.

Orthologs for EFCAB13 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia EFCAB13 35
  • 82.61 (n)
  • 66.82 (a)
EFCAB13 36
  • 64 (a)
(Pan troglodytes)
Mammalia EFCAB13 35
  • 99.11 (n)
  • 97.84 (a)
EFCAB13 36
  • 98 (a)
(Bos Taurus)
Mammalia EFCAB13 36
  • 65 (a)
(Mus musculus)
Mammalia Gm11639 36
  • 39 (a)
(Ornithorhynchus anatinus)
Mammalia EFCAB13 36
  • 31 (a)
(Anolis carolinensis)
Reptilia EFCAB13 36
  • 20 (a)
Species with no ortholog for EFCAB13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for EFCAB13 Gene

Gene Tree for EFCAB13 (if available)
Gene Tree for EFCAB13 (if available)

Paralogs for EFCAB13 Gene

(1) SIMAP similar genes for EFCAB13 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with EFCAB13: view

No data available for Paralogs for EFCAB13 Gene

Variants for EFCAB13 Gene

Sequence variations from dbSNP and Humsavar for EFCAB13 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs4968318 - 47,374,528(+) CAAGT(A/G)TAGCA reference, missense
rs17855599 - 47,395,881(+) AGACG(A/G)TGAGT reference, missense
VAR_035465 A breast cancer sample
rs55853213 - 47,370,466(+) ATATT(A/G)TATTT reference, missense
rs1128517 -- 47,368,926(+) AAAAT(A/G)GCTCT intron-variant

Variation tolerance for EFCAB13 Gene

Residual Variation Intolerance Score: 98% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.18; 87.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EFCAB13 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for EFCAB13 Gene

Disorders for EFCAB13 Gene

Relevant External Links for EFCAB13

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for EFCAB13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EFCAB13 Gene

Publications for EFCAB13 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Discovery and refinement of loci associated with lipid levels. (PMID: 24097068) . … Abecasis G.R. (Nat. Genet. 2013) 3
  3. Biological, clinical and population relevance of 95 loci for blood lipids. (PMID: 20686565) Teslovich T.M. … Kathiresan S. (Nature 2010) 3
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for EFCAB13 Gene

Sources for EFCAB13 Gene