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Aliases for EEFSEC Gene

Aliases for EEFSEC Gene

  • Eukaryotic Elongation Factor, Selenocysteine-TRNA Specific 2 3 5
  • Selenocysteine (Sec)-Specific Eukaryotic Elongation Factor 2 3
  • Elongation Factor For Selenoprotein Translation 2 3
  • Elongation Factor Sec 3 4
  • SELB 3 4
  • Eukaryotic Elongation Factor, Selenocysteine-TRNA-Specific 4
  • Selenocysteine-Specific Elongation Factor 3
  • EFSEC 3

External Ids for EEFSEC Gene

Previous GeneCards Identifiers for EEFSEC Gene

  • GC03P129356
  • GC03P127872
  • GC03P125258

Summaries for EEFSEC Gene

GeneCards Summary for EEFSEC Gene

EEFSEC (Eukaryotic Elongation Factor, Selenocysteine-TRNA Specific) is a Protein Coding gene. Among its related pathways are Metabolism and Selenium Metabolism and Selenoproteins. GO annotations related to this gene include GTP binding and tRNA binding. An important paralog of this gene is TUFM.

UniProtKB/Swiss-Prot for EEFSEC Gene

  • Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP.

Additional gene information for EEFSEC Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EEFSEC Gene

Genomics for EEFSEC Gene

Regulatory Elements for EEFSEC Gene

Enhancers for EEFSEC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H128423 1.5 Ensembl ENCODE dbSUPER 13 +272.0 272046 3.3 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF766 CBX5 ZNF143 ATF7 RUNX3 EEFSEC RUVBL1 MCM2 GC03M128409 GC03P128459
GH03H128122 1.1 ENCODE 13.2 -29.9 -29880 2.8 PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF207 RUVBL1 EEFSEC RUVBL1-AS1 RNU2-37P MCM2 PIR39032
GH03H128877 1.2 ENCODE 10.8 +726.1 726098 3.6 MLX ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 ZNF766 ZNF207 RPL32P3 ENSG00000244932 H1FX-AS1 ACAD9 ISY1 LOC653712 RUVBL1 H1FX EEFSEC EFCC1
GH03H128079 1.5 FANTOM5 ENCODE dbSUPER 7.2 -72.6 -72642 3.5 HDGF THRB RAD21 RARA YY1 ZNF366 FOS ATF7 USF2 ZEB2 GATA2 TPRA1 EFCC1 SEC61A1 EEFSEC DNAJB8 RUVBL1-AS1 PIR39032
GH03H128151 1.4 ENCODE dbSUPER 7.4 -0.6 -587 3.2 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 RUVBL1 EEFSEC RNU6-823P GC03M128142
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EEFSEC on UCSC Golden Path with GeneCards custom track

Promoters for EEFSEC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000158064 346 1601 PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 ZNF207

Genomic Locations for EEFSEC Gene

Genomic Locations for EEFSEC Gene
chr3:128,153,454-128,426,193
(GRCh38/hg38)
Size:
272,740 bases
Orientation:
Plus strand
chr3:127,872,297-128,127,489
(GRCh37/hg19)

Genomic View for EEFSEC Gene

Genes around EEFSEC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EEFSEC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EEFSEC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EEFSEC Gene

Proteins for EEFSEC Gene

  • Protein details for EEFSEC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P57772-SELB_HUMAN
    Recommended name:
    Selenocysteine-specific elongation factor
    Protein Accession:
    P57772
    Secondary Accessions:
    • Q96HZ6

    Protein attributes for EEFSEC Gene

    Size:
    596 amino acids
    Molecular mass:
    65305 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for EEFSEC Gene

    Alternative splice isoforms for EEFSEC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EEFSEC Gene

Post-translational modifications for EEFSEC Gene

  • Ubiquitination at posLast=3838
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for EEFSEC Gene

Domains & Families for EEFSEC Gene

Gene Families for EEFSEC Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for EEFSEC Gene

Suggested Antigen Peptide Sequences for EEFSEC Gene

Graphical View of Domain Structure for InterPro Entry

P57772

UniProtKB/Swiss-Prot:

SELB_HUMAN :
  • Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. SelB subfamily.
Family:
  • Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. SelB subfamily.
genes like me logo Genes that share domains with EEFSEC: view

Function for EEFSEC Gene

Molecular function for EEFSEC Gene

UniProtKB/Swiss-Prot Function:
Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP.

Phenotypes From GWAS Catalog for EEFSEC Gene

Gene Ontology (GO) - Molecular Function for EEFSEC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding IEA --
GO:0000166 nucleotide binding IEA --
GO:0003746 translation elongation factor activity IEA --
GO:0003924 GTPase activity IEA --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with EEFSEC: view

Phenotypes for EEFSEC Gene

genes like me logo Genes that share phenotypes with EEFSEC: view

Animal Model Products

CRISPR Products

miRNA for EEFSEC Gene

miRTarBase miRNAs that target EEFSEC

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EEFSEC Gene

Localization for EEFSEC Gene

Subcellular locations from UniProtKB/Swiss-Prot for EEFSEC Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EEFSEC gene
Compartment Confidence
nucleus 4
mitochondrion 3
cytosol 3
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear bodies (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for EEFSEC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0030529 intracellular ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with EEFSEC: view

Pathways & Interactions for EEFSEC Gene

genes like me logo Genes that share pathways with EEFSEC: view

Pathways by source for EEFSEC Gene

Gene Ontology (GO) - Biological Process for EEFSEC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001514 selenocysteine incorporation IEA --
GO:0006412 translation IEA --
genes like me logo Genes that share ontologies with EEFSEC: view

No data available for SIGNOR curated interactions for EEFSEC Gene

Drugs & Compounds for EEFSEC Gene

(3) Drugs for EEFSEC Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(2) Additional Compounds for EEFSEC Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with EEFSEC: view

Transcripts for EEFSEC Gene

Unigene Clusters for EEFSEC Gene

Eukaryotic elongation factor, selenocysteine-tRNA-specific:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for EEFSEC Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9
SP1: - -
SP2:
SP3: - - - -
SP4:
SP5: - - - - -

Relevant External Links for EEFSEC Gene

GeneLoc Exon Structure for
EEFSEC
ECgene alternative splicing isoforms for
EEFSEC

Expression for EEFSEC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EEFSEC Gene

Protein differential expression in normal tissues from HIPED for EEFSEC Gene

This gene is overexpressed in Lymph node (12.5) and Peripheral blood mononuclear cells (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EEFSEC Gene



Protein tissue co-expression partners for EEFSEC Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EEFSEC Gene:

EEFSEC

SOURCE GeneReport for Unigene cluster for EEFSEC Gene:

Hs.477498

Evidence on tissue expression from TISSUES for EEFSEC Gene

  • Liver(4.3)
  • Muscle(4.2)
genes like me logo Genes that share expression patterns with EEFSEC: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EEFSEC Gene

Orthologs for EEFSEC Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EEFSEC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EEFSEC 34 33
  • 99.38 (n)
OneToOne
dog
(Canis familiaris)
Mammalia EEFSEC 33 34
  • 90.66 (n)
cow
(Bos Taurus)
Mammalia EEFSEC 34 33
  • 86.08 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Eefsec 34 16 33
  • 85.74 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EEFSEC 34
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EEFSEC 34
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves EEFSEC 34 33
  • 73.26 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 82 (a)
OneToMany
-- 34
  • 72 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia eefsec 33
  • 68.58 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2115 33
zebrafish
(Danio rerio)
Actinopterygii eefsec 34 33
  • 64.23 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006250 33
  • 56.19 (n)
fruit fly
(Drosophila melanogaster)
Insecta EfSec 33 34
  • 53.85 (n)
worm
(Caenorhabditis elegans)
Secernentea selb-1 33 34
  • 46.45 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TUF1 34
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 53 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3408 33
Species where no ortholog for EEFSEC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EEFSEC Gene

ENSEMBL:
Gene Tree for EEFSEC (if available)
TreeFam:
Gene Tree for EEFSEC (if available)

Paralogs for EEFSEC Gene

Paralogs for EEFSEC Gene

genes like me logo Genes that share paralogs with EEFSEC: view

Variants for EEFSEC Gene

Sequence variations from dbSNP and Humsavar for EEFSEC Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000004336 -- 128,386,526(+) TAGTG(A/G)GGCCA intron-variant
rs1000011705 -- 128,345,292(+) AGCGT(C/G)GGTCC intron-variant
rs1000014546 -- 128,380,755(+) CCTGC(A/G)ACCTG intron-variant
rs1000024729 -- 128,422,371(+) TCCCC(A/G)GGGTC intron-variant
rs1000028182 -- 128,176,875(+) TACTA(C/G)TGATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EEFSEC Gene

Variant ID Type Subtype PubMed ID
nsv955344 CNV duplication 24416366
nsv955343 CNV duplication 24416366
nsv591596 CNV loss 21841781
nsv524397 CNV loss 19592680
nsv516926 CNV loss 19592680
nsv508240 CNV deletion 20534489
nsv475323 CNV novel sequence insertion 20440878
nsv473131 CNV novel sequence insertion 20440878
nsv470894 CNV loss 18288195
nsv3993 CNV insertion 18451855
nsv3992 CNV insertion 18451855
nsv1009435 CNV gain 25217958
nsv1009426 CNV gain 25217958
nsv1002685 CNV gain 25217958
esv3406834 CNV insertion 20981092
esv3390686 CNV insertion 20981092
esv3306834 CNV mobile element insertion 20981092
esv3303143 CNV mobile element insertion 20981092
esv32985 CNV loss 17666407
esv2759176 CNV loss 17122850
esv2725887 CNV deletion 23290073
dgv8565n54 CNV loss 21841781

Variation tolerance for EEFSEC Gene

Residual Variation Intolerance Score: 52.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.48; 55.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EEFSEC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EEFSEC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EEFSEC Gene

Disorders for EEFSEC Gene

Relevant External Links for EEFSEC

Genetic Association Database (GAD)
EEFSEC
Human Genome Epidemiology (HuGE) Navigator
EEFSEC
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EEFSEC

No disorders were found for EEFSEC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EEFSEC Gene

Publications for EEFSEC Gene

  1. Characterization of mSelB, a novel mammalian elongation factor for selenoprotein translation. (PMID: 10970870) Fagegaltier D … Krol A (The EMBO journal 2000) 2 3 4 60
  2. Inherited genetic markers discovered to date are able to identify a significant number of men at considerably elevated risk for prostate cancer. (PMID: 20878950) Sun J … Xu J (The Prostate 2011) 3 45 60
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 45 60
  5. Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. (PMID: 21102462) Elks CE … Murray A (Nature genetics 2010) 3 45 60

Products for EEFSEC Gene

Sources for EEFSEC Gene

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