Free for academic non-profit institutions. Other users need a Commercial license

Aliases for EEFSEC Gene

Aliases for EEFSEC Gene

  • Eukaryotic Elongation Factor, Selenocysteine-TRNA-Specific 2 3 4
  • Elongation Factor For Selenoprotein Translation 2 3
  • Elongation Factor Sec 3 4
  • SELB 3 4
  • EFSEC 3

External Ids for EEFSEC Gene

Previous GeneCards Identifiers for EEFSEC Gene

  • GC03P129356
  • GC03P127872
  • GC03P125258

Summaries for EEFSEC Gene

GeneCards Summary for EEFSEC Gene

EEFSEC (Eukaryotic Elongation Factor, Selenocysteine-TRNA-Specific) is a Protein Coding gene. Among its related pathways are Selenium Metabolism and Selenoproteins. GO annotations related to this gene include GTP binding and tRNA binding. An important paralog of this gene is TUFM.

UniProtKB/Swiss-Prot for EEFSEC Gene

  • Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EEFSEC Gene

Genomics for EEFSEC Gene

Regulatory Elements for EEFSEC Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for EEFSEC Gene

Chromosome:
3
Start:
128,153,454 bp from pter
End:
128,426,193 bp from pter
Size:
272,740 bases
Orientation:
Plus strand

Genomic View for EEFSEC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EEFSEC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EEFSEC Gene

Proteins for EEFSEC Gene

  • Protein details for EEFSEC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P57772-SELB_HUMAN
    Recommended name:
    Selenocysteine-specific elongation factor
    Protein Accession:
    P57772
    Secondary Accessions:
    • Q96HZ6

    Protein attributes for EEFSEC Gene

    Size:
    596 amino acids
    Molecular mass:
    65305 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for EEFSEC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EEFSEC Gene

Proteomics data for EEFSEC Gene at MOPED

Post-translational modifications for EEFSEC Gene

  • Ubiquitination at Lys 38
  • Modification sites at PhosphoSitePlus

Other Protein References for EEFSEC Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for EEFSEC Gene

Domains & Families for EEFSEC Gene

Protein Domains for EEFSEC Gene

Suggested Antigen Peptide Sequences for EEFSEC Gene

Graphical View of Domain Structure for InterPro Entry

P57772

UniProtKB/Swiss-Prot:

SELB_HUMAN :
  • Contains 1 tr-type G (guanine nucleotide-binding) domain.
  • Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. SelB subfamily.
Domain:
  • Contains 1 tr-type G (guanine nucleotide-binding) domain.
Family:
  • Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. SelB subfamily.
genes like me logo Genes that share domains with EEFSEC: view

No data available for Gene Families for EEFSEC Gene

Function for EEFSEC Gene

Molecular function for EEFSEC Gene

UniProtKB/Swiss-Prot Function:
Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP

Gene Ontology (GO) - Molecular Function for EEFSEC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding IEA --
GO:0003746 translation elongation factor activity IBA --
GO:0003924 GTPase activity IBA --
GO:0005515 protein binding --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with EEFSEC: view

Phenotypes for EEFSEC Gene

GenomeRNAi human phenotypes for EEFSEC:
genes like me logo Genes that share phenotypes with EEFSEC: view

Animal Model Products

CRISPR Products

miRNA for EEFSEC Gene

miRTarBase miRNAs that target EEFSEC

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EEFSEC

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for EEFSEC Gene

Localization for EEFSEC Gene

Subcellular locations from UniProtKB/Swiss-Prot for EEFSEC Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EEFSEC Gene COMPARTMENTS Subcellular localization image for EEFSEC gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for EEFSEC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA --
GO:0005634 nucleus IEA --
GO:0005739 mitochondrion IEA --
GO:0030529 ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with EEFSEC: view

Pathways & Interactions for EEFSEC Gene

genes like me logo Genes that share pathways with EEFSEC: view

Pathways by source for EEFSEC Gene

1 BioSystems pathway for EEFSEC Gene

Gene Ontology (GO) - Biological Process for EEFSEC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001514 selenocysteine incorporation IBA --
GO:0008152 metabolic process --
genes like me logo Genes that share ontologies with EEFSEC: view

No data available for SIGNOR curated interactions for EEFSEC Gene

Drugs & Compounds for EEFSEC Gene

(3) Drugs for EEFSEC Gene - From: NovoSeek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
Selenocysteine Experimental Pharma 0
Selenium Pharma 161

(2) Additional Compounds for EEFSEC Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
gtp
Partial agonist, Agonist
Selenophosphate
  • Dihydroxy-oxido-selanylidenephosphorane
  • Phosphorus monoselenide
  • Phosphorus selenide (PSe)
  • Selenoxo-phosphino
289702-60-9
genes like me logo Genes that share compounds with EEFSEC: view

Transcripts for EEFSEC Gene

Unigene Clusters for EEFSEC Gene

Eukaryotic elongation factor, selenocysteine-tRNA-specific:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EEFSEC

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EEFSEC Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9
SP1: - -
SP2:
SP3: - - - -
SP4:
SP5: - - - - -

Relevant External Links for EEFSEC Gene

GeneLoc Exon Structure for
EEFSEC
ECgene alternative splicing isoforms for
EEFSEC

Expression for EEFSEC Gene

mRNA expression in normal human tissues for EEFSEC Gene

Protein differential expression in normal tissues from HIPED for EEFSEC Gene

This gene is overexpressed in Lymph node (12.5) and Peripheral blood mononuclear cells (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EEFSEC Gene



SOURCE GeneReport for Unigene cluster for EEFSEC Gene Hs.477498

genes like me logo Genes that share expression patterns with EEFSEC: view

Protein tissue co-expression partners for EEFSEC Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EEFSEC Gene

Orthologs for EEFSEC Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EEFSEC Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EEFSEC 35
  • 86.08 (n)
  • 87.95 (a)
EEFSEC 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EEFSEC 35
  • 90.66 (n)
  • 91.78 (a)
EEFSEC 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eefsec 35
  • 85.74 (n)
  • 89.86 (a)
Eefsec 16
Eefsec 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EEFSEC 35
  • 99.38 (n)
  • 98.99 (a)
EEFSEC 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EEFSEC 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EEFSEC 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves EEFSEC 35
  • 73.26 (n)
  • 77.43 (a)
EEFSEC 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 82 (a)
OneToMany
-- 36
  • 72 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia eefsec 35
  • 68.58 (n)
  • 73.34 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2115 35
zebrafish
(Danio rerio)
Actinopterygii eefsec 35
  • 64.23 (n)
  • 67.79 (a)
eefsec 36
  • 65 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006250 35
  • 56.19 (n)
  • 49.43 (a)
fruit fly
(Drosophila melanogaster)
Insecta EfSec 35
  • 53.85 (n)
  • 49.9 (a)
EfSec 36
  • 44 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea selb-1 35
  • 46.45 (n)
  • 38.44 (a)
selb-1 36
  • 32 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TUF1 36
  • 25 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3408 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
OneToOne
Species with no ortholog for EEFSEC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EEFSEC Gene

ENSEMBL:
Gene Tree for EEFSEC (if available)
TreeFam:
Gene Tree for EEFSEC (if available)

Paralogs for EEFSEC Gene

Paralogs for EEFSEC Gene

genes like me logo Genes that share paralogs with EEFSEC: view

Variants for EEFSEC Gene

Sequence variations from dbSNP and Humsavar for EEFSEC Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs729847 -- 128,391,927(-) TGGCC(C/T)CCACA intron-variant
rs737200 -- 128,369,622(+) GCTTC(C/G)GAGGC intron-variant
rs741925 -- 128,391,073(+) TCCCA(C/T)CAGAA intron-variant
rs741926 -- 128,323,928(-) CAGGG(A/C/G)GGGAG intron-variant
rs741927 -- 128,323,803(-) CAACA(C/T)GGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EEFSEC Gene

Variant ID Type Subtype PubMed ID
nsv3992 CNV Insertion 18451855
esv32985 CNV Loss 17666407
esv271110 CNV Insertion 20981092
nsv470894 CNV Loss 18288195
esv2725887 CNV Deletion 23290073
dgv1493e1 CNV Complex 17122850
dgv1494e1 CNV Complex 17122850
nsv508240 CNV Loss 20534489
esv267423 CNV Insertion 20981092
nsv3993 CNV Insertion 18451855
nsv524397 CNV Loss 19592680
nsv877461 CNV Loss 21882294
dgv5250n71 CNV Loss 21882294
nsv516926 CNV Loss 19592680

Variation tolerance for EEFSEC Gene

Residual Variation Intolerance Score: 52.45% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.48; 55.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EEFSEC Gene

HapMap Linkage Disequilibrium report
EEFSEC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EEFSEC Gene

Disorders for EEFSEC Gene

Relevant External Links for EEFSEC

Genetic Association Database (GAD)
EEFSEC
Human Genome Epidemiology (HuGE) Navigator
EEFSEC
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EEFSEC
genes like me logo Genes that share disorders with EEFSEC: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EEFSEC Gene

Publications for EEFSEC Gene

  1. Thermodynamic and kinetic framework of selenocysteyl-tRNASec recognition by elongation factor SelB. (PMID: 19940162) Paleskava A. … Rodnina M.V. (J. Biol. Chem. 2010) 23 67
  2. The ribosome-bound initiation factor 2 recruits initiator tRNA to the 30S initiation complex. (PMID: 20224578) Milon P. … Gualerzi C.O. (EMBO Rep. 2010) 23 67
  3. Down-regulation of the hepatic selenoprotein biosynthesis machinery impairs selenium metabolism during the acute phase response in mice. (PMID: 19136613) Renko K. … Schomburg L. (FASEB J. 2009) 23 67
  4. Evolutionary history of selenocysteine incorporation from the perspective of SECIS binding proteins. (PMID: 19744324) Donovan J. … Copeland P.R. (BMC Evol. Biol. 2009) 23 67
  5. Phylogenetic distribution of translational GTPases in bacteria. (PMID: 17214893) Margus T. … Tenson T. (BMC Genomics 2007) 23 67

Products for EEFSEC Gene

Sources for EEFSEC Gene

Back to Top

Content