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Aliases for EEF2KMT Gene

Aliases for EEF2KMT Gene

  • Eukaryotic Elongation Factor 2 Lysine Methyltransferase 2 3
  • FAM86A 3 4 6
  • Family With Sequence Similarity 86, Member A 2 3
  • EEF2-Lysine Methyltransferase 3 4
  • EEF2-KMT 3 4
  • Putative Protein N-Methyltransferase FAM86A 3
  • Protein-Lysine N-Methyltransferase EEF2KMT 3
  • Protein FAM86A 3
  • EC 2.1.1.- 4
  • SB153 3

External Ids for EEF2KMT Gene

Previous HGNC Symbols for EEF2KMT Gene

  • FAM86A

Summaries for EEF2KMT Gene

GeneCards Summary for EEF2KMT Gene

EEF2KMT (Eukaryotic Elongation Factor 2 Lysine Methyltransferase) is a Protein Coding gene. An important paralog of this gene is FAM86B2.

UniProtKB/Swiss-Prot for EEF2KMT Gene

  • Catalyzes the trimethylation of eukaryotic elongation factor 2 (EEF2) on Lys-525.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EEF2KMT Gene

Genomics for EEF2KMT Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for EEF2KMT Gene

Start:
5,084,300 bp from pter
End:
5,097,820 bp from pter
Size:
13,521 bases
Orientation:
Minus strand

Genomic View for EEF2KMT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EEF2KMT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EEF2KMT Gene

No data available for Regulatory Elements for EEF2KMT Gene

Proteins for EEF2KMT Gene

  • Protein details for EEF2KMT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96G04-EF2KT_HUMAN
    Recommended name:
    Protein-lysine N-methyltransferase EEF2KMT
    Protein Accession:
    Q96G04
    Secondary Accessions:
    • D3DUF0
    • Q96S85

    Protein attributes for EEF2KMT Gene

    Size:
    330 amino acids
    Molecular mass:
    36915 Da
    Quaternary structure:
    • Interacts with FAM86B2 and FAM86C1.

    Alternative splice isoforms for EEF2KMT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EEF2KMT Gene

Proteomics data for EEF2KMT Gene at MOPED

Post-translational modifications for EEF2KMT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EEF2KMT Gene

No data available for DME Specific Peptides for EEF2KMT Gene

Domains for EEF2KMT Gene

Protein Domains for EEF2KMT Gene

Graphical View of Domain Structure for InterPro Entry

Q96G04

UniProtKB/Swiss-Prot:

EF2KT_HUMAN :
  • Q96G04
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.
genes like me logo Genes that share domains with EEF2KMT: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for EEF2KMT Gene

Function for EEF2KMT Gene

Molecular function for EEF2KMT Gene

UniProtKB/Swiss-Prot Function: Catalyzes the trimethylation of eukaryotic elongation factor 2 (EEF2) on Lys-525.

Enzyme Numbers (IUBMB) for EEF2KMT Gene

Gene Ontology (GO) - Molecular Function for EEF2KMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0016279 protein-lysine N-methyltransferase activity IDA 25231979
genes like me logo Genes that share ontologies with EEF2KMT: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EEF2KMT

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for EEF2KMT Gene

Localization for EEF2KMT Gene

Subcellular locations from UniProtKB/Swiss-Prot for EEF2KMT Gene

Cytoplasm.

Gene Ontology (GO) - Cellular Components for EEF2KMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with EEF2KMT: view

No data available for Subcellular locations from COMPARTMENTS for EEF2KMT Gene

Pathways for EEF2KMT Gene

SuperPathways for EEF2KMT Gene

No Data Available

Gene Ontology (GO) - Biological Process for EEF2KMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018023 peptidyl-lysine trimethylation IDA 25231979
genes like me logo Genes that share ontologies with EEF2KMT: view

No data available for Pathways by source for EEF2KMT Gene

Transcripts for EEF2KMT Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EEF2KMT

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EEF2KMT Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1:
SP2: -

Relevant External Links for EEF2KMT Gene

GeneLoc Exon Structure for
EEF2KMT
ECgene alternative splicing isoforms for
EEF2KMT

Expression for EEF2KMT Gene

mRNA expression in normal human tissues for EEF2KMT Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for EEF2KMT Gene

genes like me logo Genes that share expressions with EEF2KMT: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EEF2KMT Gene

Orthologs for EEF2KMT Gene

This gene was present in the common ancestor of animals.

Orthologs for EEF2KMT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 90 (a)
ManyToMany
LOC742623 35
  • 94.22 (n)
  • 90.21 (a)
cow
(Bos Taurus)
Mammalia FAM86A 35
  • 82.32 (n)
  • 78.48 (a)
FAM86A 36
  • 76 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 69 (a)
OneToMany
FAM86A 35
  • 83.61 (n)
  • 79.93 (a)
mouse
(Mus musculus)
Mammalia Fam86 35
  • 77.91 (n)
  • 73.25 (a)
Fam86 16
Fam86 36
  • 72 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 69 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 59 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Fam86a 35
  • 78.32 (n)
  • 72.95 (a)
chicken
(Gallus gallus)
Aves FAM86A 35
  • 61.22 (n)
  • 58.97 (a)
FAM86A 36
  • 54 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 54 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia fam86a 35
  • 56.78 (n)
  • 54.67 (a)
zebrafish
(Danio rerio)
Actinopterygii fam86a 35
  • 56.88 (n)
  • 49.49 (a)
fam86a 36
  • 47 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004255 35
  • 44.22 (n)
  • 35.67 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7889 35
  • 44.36 (n)
  • 32.71 (a)
CG7889 36
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea R08D7.4 36
  • 22 (a)
OneToMany
Species with no ortholog for EEF2KMT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EEF2KMT Gene

ENSEMBL:
Gene Tree for EEF2KMT (if available)
TreeFam:
Gene Tree for EEF2KMT (if available)

Paralogs for EEF2KMT Gene

Paralogs for EEF2KMT Gene

genes like me logo Genes that share paralogs with EEF2KMT: view

Variants for EEF2KMT Gene

Sequence variations from dbSNP and Humsavar for EEF2KMT Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1047462 -- 5,089,161(-) TCTAC(A/G)TGGCC missense, reference
rs1875222 -- 5,091,866(-) TTGGA(C/T)GAGCT intron-variant, reference, synonymous-codon, utr-variant-5-prime
rs2333956 -- 5,093,417(-) CCCGT(C/T)CTTCC intron-variant
rs2333957 -- 5,089,933(-) CATCA(A/C)AGGAC intron-variant
rs2333958 -- 5,089,900(-) TTCAA(C/G)CCACA intron-variant

Relevant External Links for EEF2KMT Gene

HapMap Linkage Disequilibrium report
EEF2KMT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for EEF2KMT Gene

Disorders for EEF2KMT Gene

No disorders were found for EEF2KMT Gene.

No data available for UniProtKB/Swiss-Prot for EEF2KMT Gene

Publications for EEF2KMT Gene

  1. Identification and characterization of a novel evolutionarily conserved lysine-specific methyltransferase targeting eukaryotic translation elongation factor 2 (eEF2). (PMID: 25231979) Davydova E. … Falnes P.O. (J. Biol. Chem. 2014) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PMID: 23349634) Cloutier P. … Coulombe B. (PLoS Genet. 2013) 3 4
  4. Exome sequencing identifies titin mutations causing hereditary myopathy with early respiratory failure (HMERF) in families of diverse ethnic origins. (PMID: 23514108) Toro C. … Goldfarb L.G. (BMC Neurol. 2013) 3
  5. Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening. (PMID: 7829101) Robertson N.G. … Morton C.C. (Genomics 1994) 3

Products for EEF2KMT Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate EEF2KMT
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for EEF2KMT
    • Block miRNA regulation of EEF2KMT using miScript Target Protectors

    Sources for EEF2KMT Gene

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