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Aliases for EEF2KMT Gene

Aliases for EEF2KMT Gene

  • Eukaryotic Elongation Factor 2 Lysine Methyltransferase 2 3 5
  • Family With Sequence Similarity 86, Member A 2 3
  • EEF2-Lysine Methyltransferase 3 4
  • EEF2-KMT 3 4
  • FAM86A 3 4
  • Putative Protein N-Methyltransferase FAM86A 3
  • Protein FAM86A 3
  • EC 2.1.1.- 4
  • SB153 3

External Ids for EEF2KMT Gene

Previous HGNC Symbols for EEF2KMT Gene

  • FAM86A

Summaries for EEF2KMT Gene

GeneCards Summary for EEF2KMT Gene

EEF2KMT (Eukaryotic Elongation Factor 2 Lysine Methyltransferase) is a Protein Coding gene. GO annotations related to this gene include protein-lysine N-methyltransferase activity. An important paralog of this gene is FAM86B2.

UniProtKB/Swiss-Prot for EEF2KMT Gene

  • Catalyzes the trimethylation of eukaryotic elongation factor 2 (EEF2) on Lys-525.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EEF2KMT Gene

Genomics for EEF2KMT Gene

Regulatory Elements for EEF2KMT Gene

Enhancers for EEF2KMT Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around EEF2KMT on UCSC Golden Path with GeneCards custom track

Promoters for EEF2KMT Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EEF2KMT on UCSC Golden Path with GeneCards custom track

Genomic Location for EEF2KMT Gene

5,084,300 bp from pter
5,097,820 bp from pter
13,521 bases
Minus strand

Genomic View for EEF2KMT Gene

Genes around EEF2KMT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EEF2KMT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EEF2KMT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EEF2KMT Gene

Proteins for EEF2KMT Gene

  • Protein details for EEF2KMT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein-lysine N-methyltransferase EEF2KMT
    Protein Accession:
    Secondary Accessions:
    • D3DUF0
    • Q96S85

    Protein attributes for EEF2KMT Gene

    330 amino acids
    Molecular mass:
    36915 Da
    Quaternary structure:
    • Interacts with FAM86B2 and FAM86C1.

    Alternative splice isoforms for EEF2KMT Gene


neXtProt entry for EEF2KMT Gene

Proteomics data for EEF2KMT Gene at MOPED

Post-translational modifications for EEF2KMT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EEF2KMT Gene

No data available for DME Specific Peptides for EEF2KMT Gene

Domains & Families for EEF2KMT Gene

Protein Domains for EEF2KMT Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.
genes like me logo Genes that share domains with EEF2KMT: view

No data available for Gene Families for EEF2KMT Gene

Function for EEF2KMT Gene

Molecular function for EEF2KMT Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the trimethylation of eukaryotic elongation factor 2 (EEF2) on Lys-525.

Enzyme Numbers (IUBMB) for EEF2KMT Gene

Gene Ontology (GO) - Molecular Function for EEF2KMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016279 protein-lysine N-methyltransferase activity IDA 25231979
genes like me logo Genes that share ontologies with EEF2KMT: view
genes like me logo Genes that share phenotypes with EEF2KMT: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for EEF2KMT Gene

Localization for EEF2KMT Gene

Subcellular locations from UniProtKB/Swiss-Prot for EEF2KMT Gene


No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for EEF2KMT Gene

Pathways & Interactions for EEF2KMT Gene

SuperPathways for EEF2KMT Gene

No Data Available

Gene Ontology (GO) - Biological Process for EEF2KMT Gene


No data available for Pathways by source and SIGNOR curated interactions for EEF2KMT Gene

Drugs & Compounds for EEF2KMT Gene

No Compound Related Data Available

Transcripts for EEF2KMT Gene

Alternative Splicing Database (ASD) splice patterns (SP) for EEF2KMT Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP2: -

Relevant External Links for EEF2KMT Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EEF2KMT Gene

mRNA expression in normal human tissues for EEF2KMT Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for EEF2KMT Gene

genes like me logo Genes that share expression patterns with EEF2KMT: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for EEF2KMT Gene

Orthologs for EEF2KMT Gene

This gene was present in the common ancestor of animals.

Orthologs for EEF2KMT Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM86A 35
  • 82.32 (n)
  • 78.48 (a)
FAM86A 36
  • 76 (a)
(Canis familiaris)
Mammalia FAM86A 35
  • 83.61 (n)
  • 79.93 (a)
-- 36
  • 69 (a)
(Mus musculus)
Mammalia Fam86 35
  • 77.91 (n)
  • 73.25 (a)
Eef2kmt 16
Fam86 36
  • 72 (a)
(Pan troglodytes)
Mammalia LOC742623 35
  • 94.22 (n)
  • 90.21 (a)
-- 36
  • 90 (a)
(Rattus norvegicus)
Mammalia Fam86a 35
  • 78.32 (n)
  • 72.95 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 59 (a)
(Gallus gallus)
Aves FAM86A 35
  • 61.22 (n)
  • 58.97 (a)
FAM86A 36
  • 54 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam86a 35
  • 56.78 (n)
  • 54.67 (a)
(Danio rerio)
Actinopterygii fam86a 35
  • 56.88 (n)
  • 49.49 (a)
fam86a 36
  • 47 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004255 35
  • 44.22 (n)
  • 35.67 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7889 35
  • 44.36 (n)
  • 32.71 (a)
CG7889 36
  • 26 (a)
(Caenorhabditis elegans)
Secernentea R08D7.4 36
  • 22 (a)
Species with no ortholog for EEF2KMT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EEF2KMT Gene

Gene Tree for EEF2KMT (if available)
Gene Tree for EEF2KMT (if available)

Paralogs for EEF2KMT Gene

Paralogs for EEF2KMT Gene

genes like me logo Genes that share paralogs with EEF2KMT: view

Variants for EEF2KMT Gene

Sequence variations from dbSNP and Humsavar for EEF2KMT Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs9673733 - 5,090,540(+) TCTCG(C/G)AGAGT reference, missense
rs3204207 - 5,089,191(-) CCTGC(C/T)GGGAG reference, missense
VAR_067704 -
rs12928528 - 5,089,185(+) CTGGT(C/G)CTCCC reference, missense
VAR_067706 -

Variation tolerance for EEF2KMT Gene

Residual Variation Intolerance Score: 94.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.56; 64.96% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for EEF2KMT Gene

Disorders for EEF2KMT Gene

Relevant External Links for EEF2KMT

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for EEF2KMT Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EEF2KMT Gene

Publications for EEF2KMT Gene

  1. Identification and characterization of a novel evolutionarily conserved lysine-specific methyltransferase targeting eukaryotic translation elongation factor 2 (eEF2). (PMID: 25231979) Davydova E. … Falnes P.O. (J. Biol. Chem. 2014) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PMID: 23349634) Cloutier P. … Coulombe B. (PLoS Genet. 2013) 3
  5. Exome sequencing identifies titin mutations causing hereditary myopathy with early respiratory failure (HMERF) in families of diverse ethnic origins. (PMID: 23514108) Toro C. … Goldfarb L.G. (BMC Neurol. 2013) 3

Products for EEF2KMT Gene

Sources for EEF2KMT Gene