EEF2K Gene
protein-coding GIFtS: 64
GCID: GC16P022217
|
|
eukaryotic elongation factor-2 kinase
| |
Aliases
for EEF2K gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Eukaryotic Elongation Factor-2 Kinase1 2 | | Calcium/Calmodulin-Dependent Eukaryotic Elongation Factor-2 Kinase2 | | EEF-2K1 | | Calmodulin-Dependent Protein Kinase III2 | | Calcium/Calmodulin-Dependent Eukaryotic Elongation Factor 2 Kinase2 3 | | Elongation Factor-2 Kinase2 | | EEF-2 Kinase2 3 | | Eukaroytic Elongation Factor 2 Kinase2 | | EC 2.7.11.203 8 | | Eukaryotic Elongation Factor 2 Kinase2 | | HSU938502 | | EC 2.7.118 |
Export aliases for EEF2K gene to outside databasesPrevious GC identifers: GC16P021638 GC16P022227 GC16P022184 GC00U916980 GC16P022125 GC16P020462 |
Summaries
for EEF2K gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for EEF2K:
This gene encodes a highly conserved protein kinase in the calmodulin-mediated signaling pathway that links activationof cell surface receptors to cell division. This kinase is involved in the regulation of protein synthesis. Itphosphorylates eukaryotic elongation factor 2 (EEF2) and thus inhibits the EEF2 function. The activity of this kinaseis increased in many cancers and may be a valid target for anti-cancer treatment. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: EF2K_HUMAN, O00418Function: Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Uponactivation by a variety of upstream kinases including AMPK or TRM7, phosphorylates the elongation factor EEF2 at asingle site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced
 summary
for EEF2K: Calmodulin-dependent kinases (CaMK) are a family of serine/threonine kinases that mediate many of the second
messenger effects of Ca2+. At basal Ca2+ levels, CaMKs are maintained in a dormant state through
autoinhibition. Increases in Ca2+ levels allows calmodulin to relieve this autoinhibition and activate the
kinase activity. There are two main classes of CaMKs; mulitfunctional CaMKs (CaMKK, CaMKI, CaMKII and
CaMKIV) which have multiple downstream targets and substrate-specific CaMKs (CaMKIII) which have only one
known downstream target. All CaMKs, with the exception of CaMKII, exist as monomers and most are expressed
ubiquitously. Some subtypes display specific distributions, for example, CaMKIVbeta is expressed exclusively
in cerebellar granule cells. CaMKs have numerous cellular functions and they influence processes as diverse
as gene transcription, cell survival, apoptosis, cytoskeletal re-organization and learning and memory.
Gene Wiki entry for EEF2K
|
Genomic Views
for EEF2K gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the EEF2K gene promoter:
STAT1 Pbx1a STAT1beta STAT1alpha SRY FOXO1a ZID AP-2alpha FOXO1 AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for EEF2K
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EEF2K |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p12.2 Ensembl cytogenetic band: 16p12.2 HGNC cytogenetic band: 16p12EEF2K Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P022217: view genomic region
(about GC identifiers)
Start:
|
22,217,592 bp from pter |
End:
|
22,300,066 bp from pter |
Size:
|
82,475 bases |
Orientation:
|
plus strand |
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Proteins
for EEF2K gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: EF2K_HUMAN, O00418 (See
protein sequence)Recommended Name: Eukaryotic elongation factor 2 kinase Size: 725 amino acids; 82144 Da
Subunit: Monomer or homodimer (Potential)
Secondary accessions: Q8N588Explore the universe of human proteins at neXtProt for EEF2K: NX_O00418
Post-translational modifications:
Autophosphorylated at multiple residues, Thr-348 being the major site. Phosphorylated by AMP-activated protein kinaseAMPK at Ser-398 leading to EEF2K activation and protein synthesis inhibition. Phosphorylated by TRPM7 at Ser-78resulting in improved protein stability, higher EE2F phosphorylated and subsequently reduced rate of proteinsynthesis. Phosphorylation by other kinases such as CDK1 and MAPK13 at Ser-359 or RPS6KA1 and RPS6KB1 at Ser-366instead decrease EEF2K activity and promote protein synthesis1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O00418
4 DME Specific Peptides for EEF2K (O00418)
EEF2K Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_037434.1
ENSEMBL proteins: ENSP00000263026 ENSP00000456243 Reactome Protein details: O00418
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
EEF2K for ontologies About GeneDecksing
EEF2K Antibody Products:
Assay Products for EEF2K: |
Protein
Domains /
Families
for EEF2K gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
EEF2K for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O00418ProtoNet protein and cluster: O00418 2 Blocks protein families: IPB004166 MHCK/EF2 kinase domain IPB006597 Sel1-like repeat
UniProtKB/Swiss-Prot: EF2K_HUMAN, O00418Domain: The catalytic domain is located to N-terminal region. The neighbor region contains the calmodulin-bindingdomainSimilarity: Belongs to the protein kinase superfamily. Alpha-type protein kinase familySimilarity: Contains 1 alpha-type protein kinase domain |
Function
for EEF2K gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: EF2K_HUMAN, O00418Function: Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Uponactivation by a variety of upstream kinases including AMPK or TRM7, phosphorylates the elongation factor EEF2 at asingle site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reducedCatalytic activity: ATP + [elongation factor 2] = ADP + [elongation factor 2] phosphateEnzyme regulation: Undergoes calcium/calmodulin-dependent intramolecular autophosphorylation, and this results in itbecoming partially calcium/calmodulin-independent (By similarity)Enzyme Numbers (IUBMB): EC 2.7.11.201 2 EC 2.7.112
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EEF2K (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EEF2K (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: EEF2K (NM_013302) | |  | Sino Biological Human cDNA Clone for EEF2K | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EEF2K | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EEF2K |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EEF2K |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table
EEF2K for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for EEF2K:
Animal Models:
Mouse knock-out Eef2ktm1Agry for EEF2K
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Eef2k):
EEF2K for phenotypes About GeneDecksing
|
Pathways & Interactions
for EEF2K gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | IRS-related events | | | 2 | Development_CNTF receptor signaling | | | 3 | mTORC1-mediated signalling | | | 4 | Translation_Translation regulation by Alpha-1 adrenergic receptors | | | 5 | mTOR signalling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 EMD Millipore Pathways for EEF2K
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for EEF2K
1 
Cell Signaling Technology (CST) Pathway for EEF2K
3  GeneGo (Thomson Reuters) Pathways for EEF2K
4  BioSystems Pathways for EEF2K
5/14 
Reactome Pathways for EEF2K (see all 14)
EEF2K for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for EEF2K
STRING Interaction
Network Preview (showing 5 interactants - click image to see 23)
5/31 Interacting proteins for EEF2K (O004182, 3 ENSP000002630264) via UniProtKB, MINT, STRING, and/or I2D (see all 31)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
EEF2K for ontologies About GeneDecksing
|
Drugs & Compounds
for EEF2K gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
EEF2K for compounds About GeneDecksing
Compounds for EEF2K available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| NH 125 | CaM kinase III (eEF-2 kinase) inhibitor | [278603-08-0] | | A 484954 | CaM kinase III (eEF-2 kinase) inhibitor | [142557-61-7] |
1 HMDB Compound for EEF2K About this table
10/14 Novoseek chemical compound relationships for EEF2K gene (see all 14) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| rottlerin |
72.5 |
8 |
8307162 (1), 9056675 (1), 18712774 (1), 17164244 (1) (see all 5) |
| rapamycin |
64.3 |
11 |
15024086 (2), 11500364 (1), 15341530 (1), 16098202 (1) (see all 7) |
| anisomycin |
47.5 |
7 |
12171600 (3), 11500363 (2) |
| atp |
29.3 |
7 |
20300520 (2), 12416990 (1), 19244119 (1), 10913818 (1) |
| nmda |
23.4 |
2 |
16606372 (1), 16405506 (1) |
| cyclic amp |
19.9 |
3 |
1689374 (2) |
| calcium |
18.2 |
14 |
10373476 (1), 16606372 (1), 17187762 (1), 18988891 (1) (see all 8) |
| tyrosine |
12.3 |
5 |
9030224 (1), 8297101 (1), 15114688 (1), 8368481 (1) (see all 5) |
| serine |
9.7 |
1 |
11500364 (1) |
| forskolin |
9.6 |
3 |
12834812 (2), 1689374 (1) |
Search CenterWatch for drugs/clinical trials and news about EEF2K / EF2K
|
Transcripts
for EEF2K gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for EEF2K gene: NM_013302.3 Unigene Cluster for EEF2K: Eukaryotic elongation factor-2 kinase Hs.498892 [show with all ESTs]Unigene Representative Sequence: NM_0133024 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000263026(uc002dkh.3 uc002dki.3) ENST00000568269 ENST00000563555
ENST00000561791
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EEF2K (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EEF2K (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: EEF2K (NM_013302) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EEF2K | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EEF2K |
Additional cDNA sequence: AK022569.1 AK308757.1 BC032665.1 U93850.1 18 DOTS entries: DT.100695957 DT.100791745 DT.91721105 DT.95231461 DT.100702838 DT.120658706 DT.214535 DT.91649897 DT.100716784 DT.100810072 DT.120659007 DT.100791746 DT.95089310 DT.97820419 DT.120658785 DT.70104196 DT.86849745 DT.97787922 24/139 AceView cDNA sequences (see all 139): AW661897 BQ686526 AI149514 AW173696 AA744627 NM_013302 BQ012225 BX641681 BU633308 BQ672427 CF541054 AI041583 CF528464 CB265331 AI087877 AU279717 BQ671518 BF740017 AU185849 AA324198 CR621051 CD515600 BF001312 AA211372
GeneLoc Exon Structure
|
Expression
for EEF2K gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| EEF2K expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCGAGACCCT
About this image
See EEF2K Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for EEF2K
SOURCE GeneReport for Unigene cluster: Hs.498892
SABiosciences Custom PCR Arrays for EEF2K
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EEF2K
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EEF2K | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EEF2K | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EEF2K | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EEF2K |
Orthologs
for EEF2K gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for EEF2K gene from 5/22 species (see all 22) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
EEF2K1 |
eukaryotic elongation factor-2 kinase |
74.25(n)
78.9(a) |
|
416619 XM_414920.3 XP_414920.2 |
lizard
(Anolis carolinensis) |
Reptilia |
EEF2K6 |
-- |
76(a) |
1 ↔ 1 |
GL343846.1(57497-77114) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.186332 |
Xenopus laevis transcribed sequence with weak similarity more |
80.58(n) |
|
AW641430.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
eef2k1 |
elongation factor-2 kinase |
65.51(n)
67.72(a) |
|
437013 NM_001002740.1 NP_001002740.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
efk-11 , 3 |
Expression: embryo3
Protein EFK-11 |
63(a)3
49.54(n)1
46.22(a)1 |
|
III(6237055-6240296)3
1758711 NM_001027402.21 NP_001022573.11 |
ENSEMBL Gene Tree for EEF2K (if available)
TreeFam Gene Tree for EEF2K (if available) |
Paralogs
for EEF2K gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for EEF2K gene
- ALPK12
EEF2K for paralogs About GeneDecksing
|
Genomic Variants
for EEF2K gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for EEF2K (22217592 - 22300066 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 8 variations for EEF2K
3 CNVs: 49676 23249 3996
5 Inversions: 37178 0481 29493 29492 0482
Human Gene Mutation Database (HGMD): EEF2K
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EEF2K |
|
Disorders
/ Diseases
for EEF2K gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
EEF2K for disorders About GeneDecksing
OMIM gene information: 606968
OMIM disorders: --
14  diseases for EEF2K: About MalaCardstuberous sclerosis malignant glioma squamous cell carcinoma gastric ulcer
breast cancer glioblastoma choroiditis alzheimer's disease
ischemia hypoxia retinitis carcinoma
neuronitis alcoholism
5 Novoseek disease relationships for EEF2K gene About this table
Human Genome Epidemiology (HuGE) Navigator: EEF2K (2 documents)
Export disorders for EEF2K gene to outside databases
|
Publications
for EEF2K gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for EEF2K gene, integrated from 9 sources (see all 108):
(articles sorted by number of sources associating them with EEF2K) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of a new class of protein kinases represented by eukaryotic elongation factor-2 kinase. (PubMed id 9144159)1, 2, 3, 9 Ryazanov A.G.... Hait W.N. (1997)
- Mapping the functional domains of elongation factor-2 kinase. (PubMed id 11015200)1, 2, 9 Pavur K.S....Ryazanov A.G. (2000)
- Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398. (PubMed id 14709557)1, 2, 9 Browne G.J....Proud C.G. (2004)
- A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38delta. (PubMed id 11500363)1, 2, 9 Knebel A.... Cohen P. (2001)
- Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase. (PubMed id 11500364)1, 2, 9 Wang X....Proud C.G. (2001)
- Identification of autophosphorylation sites in eukaryotic elongation factor-2 kinase. (PubMed id 22216903)1, 2 Pyr Dit Ruys S.... Proud C.G. (2012)
- cdc2-cyclin B regulates eEF2 kinase activity in a cell cycle- and amino acid-dependent manner. (PubMed id 18337751)1, 2 Smith E.M. and Proud C.G. (2008)
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (2004)
|
External Searches for EEF2K gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing EEF2K gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing EEF2K gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing EEF2K gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for EEF2K gene:
Search GeneIP for patents involving EEF2K
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for EEF2K gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for EEF2K | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EEF2K | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EEF2K | | | OriGene Protein Over-expression Lysate for EEF2K | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for EEF2K | | OriGene 3'-UTR Clone for EEF2K | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EEF2K | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EEF2K | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for EEF2K | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for EEF2K | | OriGene Custom Protein Services for EEF2K | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat EEF2K | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EEF2K | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EEF2K | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EEF2K | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EEF2K | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EEF2K |
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| | Antibodies & Assays for EEF2K |
| | | | Tocris compounds for EEF2K |
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 | | | EEF2K Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EEF2K |
|  |  |  | | | | ThermoFisher Antibody for EEF2K |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EEF2K |
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