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EEF2K Gene

protein-coding GIFtS: 62

GC16P022125

eukaryotic elongation factor-2 kinase
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 2.7.11.20 ^³
HSU93850 ^²
MGC45041 ^²
eEF-2K ^¹, ², ³

Descriptions
Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase ^³
calcium/calmodulin-dependent eukaryotic elongation factor-2 kinase ^²
calmodulin-dependent protein kinase III ^²
eEF-2 kinase ^², ³
elongation factor-2 kinase ^²
eukaryotic elongation factor-2 kinase ^²

External Ids
HGNC: 24615¹
Entrez Gene: 29904²
UniProtKB: O00418³
Ensembl: ENSG00000103319⁷

Search outside databases for aliases for EEF2K gene

Previous GC identifers: GC16P021638 GC16P022227 GC16P022184 GC00U916980

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for EEF2K:

This gene encodes a highly conserved protein kinase in the calmodulin-mediated signaling pathway

that links activation of cell surface receptors to cell division. This kinase is involved in the

regulation of protein synthesis. It phosphorylates eukaryotic elongation factor 2 (EEF2) and thus

inhibits the EEF2 function. The activity of this kinase is increased in many cancers and may be a

valid target for anti-cancer treatment. [provided by RefSeq]

UniProtKB/Swiss-Prot: EF2K_HUMAN, O00418

Function: Phosphorylates eukaryotic elongation factor-2. Binds calmodulin (By similarity)

Gene Wiki entry for EEF2K

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the EEF2K gene

Entrez Gene cytogenetic band: 16p12.1 Ensembl cytogenetic band: 16p12.1 HGNC cytogenetic band: 16p12

EEF2K Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P022125: (about GC identifiers)

Start:	22,125,093 bp from pter
End:	22,207,567 bp from pter
Size:	82,475 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000016.8 NT_010393.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: EF2K_HUMAN, O00418 (See protein sequence)

Recommended Name: Elongation factor 2 kinase

Size: 725 amino acids; 82172 Da

Subunit: Monomer or homodimer (Potential)

Secondary accessions: Q8N588

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_037434.1

ENSEMBL proteins:

ENSP00000263026

Human Recombinant Proteins

	Invitrogen human recombinant proteins for EEF2K
	Millipore Purified and/or Recombinant EEF2K Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (EEF2K)
	Human Recombinant Proteins from Abnova (EEF2K)

OriGene Purified Recombinant Human Protein: EEF2K

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	TAS	9144159
GO:0005829	cytosol	EXP	15809305

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Antibodies for EEF2K:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of EEF2K
	Sigma-Aldrich Antibodies for EEF2K
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for EEF2K
	Antibodies from Abcam (EEF2K), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (EEF2K)
	Novus Biologicals Antibodies for EEF2K

Assays for EEF2K:

	Invitrogen Assays for EEF2K
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry O00418

ProtoNet protein and cluster: O00418

2 Blocks protein families:

IPB004166 MHCK/EF2 kinase domain

IPB006597 Sel1-like repeat

UniProtKB/Swiss-Prot: EF2K_HUMAN, O00418

Similarity: Belongs to the protein kinase superfamily. Alpha-type protein kinase family

Similarity: Contains 1 alpha-type protein kinase domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (EEF2K)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (EEF2K)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_013302

Applied Biosystems Silencer® siRNAs for EEF2K

Sigma-Aldrich siRNA and siRNA Panels for EEF2K

Sigma-Aldrich shRNA Panels and shRNA for EEF2K

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for EEF2K
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_013302
Myc/DDK tagged cDNA clone in CMV expression vector: NM_013302
untagged cDNA clones in CMV expression vector (see all 2): NM_013302

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_013302

UniProtKB/Swiss-Prot: EF2K_HUMAN, O00418

Function: Phosphorylates eukaryotic elongation factor-2. Binds calmodulin (By similarity)

Catalytic activity: ATP + [elongation factor 2] = ADP + [elongation factor 2] phosphate

Enzyme regulation: Undergoes calcium/calmodulin-dependent intramolecular autophosphorylation, and

this results in it becoming partially calcium/calmodulin-independent (By similarity)

Enzyme Number (IUBMB): EC 2.7.11.20

5/8 Gene Ontology (GO) molecular function terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004674	protein serine/threonine kinase activity	IEA	--
GO:0004686	elongation factor-2 kinase activity	IEA	--
GO:0005509	calcium ion binding	IEA	--
GO:0005516	calmodulin binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for EEF2K (Your Favorite Gene powered by Ingenuity)

p38 MAPK Signaling

GeneDecks EEF2K for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for EEF2K

5/24 Interacting proteins for EEF2K (O00418² ENSP00000263026³) via UniProtKB, MINT, and/or STRING (see all 24 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RPS6KB2	Q9UBS0², ENSP00000308413³	MINT-15495 STRING (score=.948)
RPS6KA1	Q15418², ENSP00000363277³	MINT-17060 STRING (score=.904)
CDC2	P06493²	MINT-6549314 MINT-6549429 MINT-6549466
ACADVL	P49748²	MINT-6549314
ALB	P02768²	MINT-6549314

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006414	translational elongation	TAS	9144159
GO:0006468	protein amino acid phosphorylation	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for EEF2K available from Tocris Bioscience

Compound	Action	CAS number
NH 125	CaM kinase III (eEF-2 kinase) inhibitor	[278603-08-0]

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7 Novoseek chemical compound relationships for EEF2K gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
atp	23.60	3	12416990 (1), 19244119 (1), 10913818 (1)
cyclic amp	21.67	3	1689374 (2)
calcium	20.44	14	10373476 (1), 16606372 (1), 17187762 (1), 18988891 (1) (see all 8)
tyrosine	14.69	5	9030224 (1), 8297101 (1), 15114688 (1), 8368481 (1) (see all 5)
forskolin	11.44	3	12834812 (2), 1689374 (1)
histidine	8.52	1	1730643 (1)
threonine	5.67	1	1730643 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (EEF2K)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (EEF2K)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_013302

Sigma-Aldrich siRNA and siRNA Panels for EEF2K

Sigma-Aldrich shRNA Panels and shRNA for EEF2K

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_013302

REFSEQ mRNAs for EEF2K gene:

NM_013302.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_013302

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_013302
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_013302
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_013302

Additional cDNA sequence:

AK022569.1 AK308757.1 BC032665.1 CR621051.1 U93850.1

20 DOTS entries:

DT.100695957 DT.100791745 DT.91721105 DT.95231461 DT.100702838 DT.120659007 DT.120658706 DT.214535

DT.91649897 DT.100810072 DT.100716784 DT.100791746 DT.95089310 DT.97820419 DT.120658785 DT.70104196

DT.86849745 DT.91960683 DT.95298358 DT.97787922

24/139 AceView cDNA sequences (see all 139 ):

BQ686526 AI041583 AW173696 AW675420 AA324198 AA211372 AU279717 BQ672427

BM769317 AU185849 BX641681 BG057770 AW661897 BQ012225 BF108667 BF740017

CD515600 BF001312 CF541054 AA744627 BM556214 AI149514 BQ671518 CF528464

highest scoring ESTs for EEF2K:

AA152340 AA324198 AA744627 AA748060 AA988161 AI041583 AI087877 AI149514 AI453505 AI655968

Unigene Cluster for EEF2K:

Eukaryotic elongation factor-2 kinase

Hs.498892 [show with all ESTs]

Unigene Representative Sequence: NM_013302

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000263026

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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EEF2K expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for EEF2K

¹ / ² / ³

6 probe-sets matching EEF2K gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
50264_at²^{, 3}	U95-B	1	1.00	1.00	0.96	1.02	W67721	0.40	1.00	0.76	1
44080_at²^{, 3}	U95-B	1	0.94	1.00	0.93	0.98	W68180	0.60	1.00	0.82	1
225546_at²^{, 3}	U133-B	1	1.00	1.00	--	--	W68180	0.60	1.00	0.82	1
225545_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BF001312	0.80	1.00	0.91	1
225546_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
225545_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GCGAGACCCT

SOURCE GeneReport for Unigene cluster: Hs.498892

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for EEF2K gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	EEF2K¹	--	eukaryotic elongation factor-2 kinase	89.56(n) 93.24(a)	479812 XM_536939.2 XP_536939.2
chimpanzee (Pan troglodytes)	EEF2K¹	--	eukaryotic elongation factor-2 kinase	99.31(n) 99.03(a)	454350 XM_511200.2 XP_511200.2
cow (Bos taurus)	EEF2K¹	--	eukaryotic elongation factor-2 kinase	89.17(n) 91.42(a)	521730 XM_599997.3 XP_599997.2
rat (Rattus norvegicus)	Eef2k¹	--	eukaryotic elongation factor-2 kinase	85.73(n) 90.33(a)	25435 NM_012947.1 NP_037079.1
mouse (Mus musculus)	Eef2k^{1, 5}	7⁵	eukaryotic elongation factor-2 kinase^{1, 5}	85.91(n)¹ 90.19(a)¹	13631¹ NM_007908.3¹ NP_031934.1¹ AI414444⁵ AI428436⁵ (see all 27)

About this table Species with no ortholog for EEF2K

ENSEMBL Gene Tree for EEF2K

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for EEF2K gene

ALPK1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/367 NCBI SNPs in EEF2K are shown (see all 367 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 86)

AB	SNP ID	Valid	Chr 16 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs9935059^1,2	A,C,F,H	22144619(+)	`TGGCCA/GTGATG`	1	H/R	mis¹		9		EU EA WA NA	914
	rs9938722^1,2	A,C,F,H	22203964(+)	`AATGTG/CAGAGC`	1	--	ut3¹		8		EU EA WA	836
	rs2290829^1,2	A,C,F,H	22203987(-)	`GTGTGG/TGTCTG`	1	--	ut3¹		10		EA NA EU WA	2226
	rs13313556^1,2	C,F,H	22205502(+)	`AACCCT/GTGACT`	1	--	ut3¹		4		EU EA WA	420
	rs17841292^1,2	C,F,H	22144774(+)	`GGTCCC/GCGGCA`	1	P/A	mis¹ ese³		17		NA EA EU WA	1526
	rs9925881^1,2	C,F,H	22123827(+)	`CTTTGG/AGCTTG`	1	--	ng5¹		8		EU EA WA	834
	rs4783453^1,2	C,H	22177368(+)	`CCCCCG/AAGTAA`	1	Q/R	mis¹		4		EU EA WA	420
--	rs11863455^1,2	A,C	22206928(+)	`tgtctC/Tggcct`	1	--	ut3¹		0	--	--	--	--
	rs2290828^1,2	F,H	22204104(-)	`GGACCA/GGGGCT`	1	--	ut3¹		5		EA EU WA	1494
--	rs11643141^1,2	C	22124279(+)	`acaggG/Ttttta`	1	--	ng5¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for EEF2K (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 606968

5 Novoseek disease relationships for EEF2K gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
glioblastoma	18.53	6	16540650 (5)
glioma	17.24	2	14583488 (1), 19244119 (1)
cancer	0.00	4	16540650 (2), 14583488 (1), 19244119 (1)
breast cancer	0.00	3	16648488 (1), 10408694 (1)
tumors	0.00	3	16540650 (2), 19244119 (1)

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Human Gene Mutation Database: EEF2K

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/81 PubMed articles for EEF2K gene (see all 81 ):

Identification of a new class of protein kinases represented by eukaryotic elongation factor-2 kinase. (PubMed id 9144159)^{1, 2, 3, 4} Ryazanov A.G.... Hait W.N. (1997)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{3, 4} Beausoleil S.A.... Gygi S.P. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)^{3, 4} Brill L.M....Peters E.C. (2004)
Detection of anti-elongation factor 2 kinase (calmodulin-dependent protein kinase III) antibodies in patients with systemic lupus erythematosus. (PubMed id 12051769)^{2, 3} Arora S....Hait W. (2002)
Mapping the functional domains of elongation factor-2 kinase. (PubMed id 11015200)^{1, 3} Pavur K.S....Ryazanov A.G. (2000)
Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398. (PubMed id 14709557)^{1, 3} Browne G.J....Proud C.G. (2004)
Stress-induced regulation of eukaryotic elongation factor 2 kinase by SB 203580-sensitive and -insensitive pathways. (PubMed id 12171600)^{1, 3} Knebel A....Cohen P. (2002)
Phosphorylation of elongation factor-2 kinase on serine 499 by cAMP-dependent protein kinase induces Ca2+/calmodulin-independent activity. (PubMed id 11171059)^{1, 3} Diggle T.A....Redpath N.T. (2001)
A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38delta. (PubMed id 11500363)^{1, 3} Knebel A.... Cohen P. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 29904	HGNC: 24615	AceView: EEF2K	Ensembl:ENSG00000103319	euGenes: HUgn29904
ECgene: EEF2K	H-InvDB: EEF2K

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for EEF2K	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for EEF2K
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for EEF2K:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for EEF2K-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for EEF2K		Antibodies for EEF2K
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for EEF2K		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (EEF2K)
	Antibodies (EEF2K)
	Chimera RNAi (EEF2K)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for EEF2K

	Recombinant Proteins (EEF2K)
	Antibodies (EEF2K)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Tocris compounds for EEF2K

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for EEF2K

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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EEF2K Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for EEF2K

Summaries
for EEF2K

Genomic Location
for EEF2K

Proteins
for EEF2K

Protein Domains/
Families
for EEF2K

Gene Function
for EEF2K

Pathways & Interactions
for EEF2K

Drugs & Compounds
for EEF2K

Transcripts
for EEF2K

Expression
for EEF2K

Orthologs
for EEF2K

Paralogs
for EEF2K

SNPs/Variants
for EEF2K

Disorders & Mutations
for EEF2K

Medical News
for EEF2K

Publications
for EEF2K

Search for EEF2K

Genome Databases showing EEF2K

Other Databases showing EEF2K

Specialized Databases showing EEF2K

Licensable Technologies
for EEF2K

Services
for EEF2K

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

EEF2K Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor EEF2K

Summariesfor EEF2K

Genomic Locationfor EEF2K

Proteinsfor EEF2K

Protein Domains/Familiesfor EEF2K

Gene Functionfor EEF2K

Pathways & Interactionsfor EEF2K

Drugs & Compoundsfor EEF2K

Transcriptsfor EEF2K

Expression for EEF2K

Orthologsfor EEF2K

Paralogsfor EEF2K

SNPs/Variantsfor EEF2K

Disorders & Mutationsfor EEF2K

Medical Newsfor EEF2K

Publicationsfor EEF2K

Search for EEF2K

Genome Databases showing EEF2K

Other Databases showing EEF2K

Specialized Databases showing EEF2K

Licensable Technologiesfor EEF2K

Servicesfor EEF2K

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for EEF2K

Summaries
for EEF2K

Genomic Location
for EEF2K

Proteins
for EEF2K

Protein Domains/
Families
for EEF2K

Gene Function
for EEF2K

Pathways & Interactions
for EEF2K

Drugs & Compounds
for EEF2K

Transcripts
for EEF2K

Expression
for EEF2K

Orthologs
for EEF2K

Paralogs
for EEF2K

SNPs/Variants
for EEF2K

Disorders & Mutations
for EEF2K

Medical News
for EEF2K

Publications
for EEF2K

Licensable Technologies
for EEF2K

Services
for EEF2K