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EEF2K Gene

protein-coding   GIFtS: 69
GCID: GC16P022217

Eukaryotic Elongation Factor-2 Kinase

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Eukaryotic Elongation Factor-2 Kinase1 2     Calcium/Calmodulin-Dependent Eukaryotic Elongation Factor-2 Kinase2
Calcium/Calmodulin-Dependent Eukaryotic Elongation Factor 2 Kinase2 3     Calmodulin-Dependent Protein Kinase III2
eEF-2K2 3     Elongation Factor-2 Kinase2
EEF-2 Kinase2 3     Eukaroytic Elongation Factor 2 Kinase2
EC 2.7.11.203 8     Eukaryotic Elongation Factor 2 Kinase2
HSU938502     EC 2.7.118

External Ids:    HGNC: 246151   Entrez Gene: 299042   Ensembl: ENSG000001033197   OMIM: 6069685   UniProtKB: O004183   

Export aliases for EEF2K gene to outside databases

Previous GC identifers: GC16P021638 GC16P022227 GC16P022184 GC00U916980 GC16P022125 GC16P020462


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for EEF2K Gene:
This gene encodes a highly conserved protein kinase in the calmodulin-mediated signaling pathway that links
activation of cell surface receptors to cell division. This kinase is involved in the regulation of protein
synthesis. It phosphorylates eukaryotic elongation factor 2 (EEF2) and thus inhibits the EEF2 function. The
activity of this kinase is increased in many cancers and may be a valid target for anti-cancer treatment.
(provided by RefSeq, Jul 2008)

GeneCards Summary for EEF2K Gene:
EEF2K (eukaryotic elongation factor-2 kinase) is a protein-coding gene. GO annotations related to this gene include calmodulin binding and calcium ion binding. An important paralog of this gene is ALPK1.

UniProtKB/Swiss-Prot: EF2K_HUMAN, O00418
Function: Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation.
Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor
EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein
synthesis is reduced

summary for EEF2K Gene:
Calmodulin-dependent kinases (CaMK) are a family of serine/threonine kinases that mediate many of the second
messenger effects of Ca2+. At basal Ca2+ levels, CaMKs are maintained in a dormant state through
autoinhibition. Increases in Ca2+ levels allows calmodulin to relieve this autoinhibition and activate the
kinase activity. There are two main classes of CaMKs; mulitfunctional CaMKs (CaMKK, CaMKI, CaMKII and
CaMKIV) which have multiple downstream targets and substrate-specific CaMKs (CaMKIII) which have only one
known downstream target. All CaMKs, with the exception of CaMKII, exist as monomers and most are expressed
ubiquitously. Some subtypes display specific distributions, for example, CaMKIVbeta is expressed exclusively
in cerebellar granule cells. CaMKs have numerous cellular functions and they influence processes as diverse
as gene transcription, cell survival, apoptosis, cytoskeletal re-organization and learning and memory.

Gene Wiki entry for EEF2K Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_187260.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the EEF2K gene promoter:
         STAT1   Pbx1a   STAT1beta   STAT1alpha   SRY   FOXO1a   ZID   AP-2alpha   FOXO1   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEEF2K promoter sequence
   Search Chromatin IP Primers for EEF2K

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EEF2K


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p12.2   Ensembl cytogenetic band:  16p12.2   HGNC cytogenetic band: 16p12

EEF2K Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EEF2K gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P022217:  view genomic region     (about GC identifiers)

Start:
22,217,592 bp from pter      End:
22,300,066 bp from pter
Size:
82,475 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: EF2K_HUMAN, O00418 (See protein sequence)
Recommended Name: Eukaryotic elongation factor 2 kinase  
Size: 725 amino acids; 82144 Da
Subunit: Monomer or homodimer (Potential)
Secondary accessions: Q8N588

Explore the universe of human proteins at neXtProt for EEF2K: NX_O00418

Explore proteomics data for EEF2K at MOPED

Post-translational modifications: 

  • Autophosphorylated at multiple residues, Thr-348 being the major site. Phosphorylated by AMP-activated protein
    kinase AMPK at Ser-398 leading to EEF2K activation and protein synthesis inhibition. Phosphorylated by TRPM7 at
    Ser-78 resulting in improved protein stability, higher EE2F phosphorylated and subsequently reduced rate of
    protein synthesis. Phosphorylation by other kinases such as CDK1 and MAPK13 at Ser-359 or RPS6KA1 and RPS6KB1 at
    Ser-366 instead decrease EEF2K activity and promote protein synthesis1
  • Ubiquitination2 at Lys65, Lys162, Lys238, Lys341, Lys347, Lys485, Lys603, Lys705
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for EEF2K (O00418)
     DIQGVGD  TPQAFSHF  IEGKYIKYNSNSGFV  RLTPQAFSHFTFERSGHQ 


    See EEF2K Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_037434.1  
    ENSEMBL proteins: 
     ENSP00000263026   ENSP00000456243  
    Reactome Protein details: O00418

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: eukaryotic elongation factor-2 kinase
    eEF2K subfamily

    5 InterPro protein domains:
     IPR017400 Elongation_factor_2_kinase
     IPR011990 TPR-like_helical
     IPR011009 Kinase-like_dom
     IPR004166 MHCK_EF2_kinase
     IPR006597 Sel1-like

    Graphical View of Domain Structure for InterPro Entry O00418

    ProtoNet protein and cluster: O00418

    2 Blocks protein domains:
    IPB004166 MHCK/EF2 kinase domain
    IPB006597 Sel1-like repeat


    UniProtKB/Swiss-Prot: EF2K_HUMAN, O00418
    Domain: The catalytic domain is located to N-terminal region. The neighbor region contains the calmodulin-binding
    domain
    Similarity: Belongs to the protein kinase superfamily. Alpha-type protein kinase family
    Similarity: Contains 1 alpha-type protein kinase domain


    Find genes that share domains with EEF2K           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EF2K_HUMAN, O00418
    Function: Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation.
    Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor
    EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein
    synthesis is reduced
    Catalytic activity: ATP + [elongation factor 2] = ADP + [elongation factor 2] phosphate
    Enzyme regulation: Undergoes calcium/calmodulin-dependent intramolecular autophosphorylation, and this results in
    it becoming partially calcium/calmodulin-independent (By similarity)

         Enzyme Numbers (IUBMB): EC 2.7.11.201 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS9144159
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004686elongation factor-2 kinase activity IDA9144159
    GO:0005509calcium ion binding IEA--
    GO:0005516calmodulin binding IDA9144159
         
    Find genes that share ontologies with EEF2K           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for EEF2K:
     Decreased focal adhesion (FA)   Paclitaxel antagonistic effect 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Eef2k):
     homeostasis/metabolism 

    Find genes that share phenotypes with EEF2K           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Eef2ktm1Agry for EEF2K

       genOway: Develop your customized and physiologically relevant rodent model for EEF2K

    miRNA
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    miRTarBase miRNAs that target EEF2K:
    hsa-mir-9-5p (MIRT021460), hsa-mir-16-5p (MIRT051093), hsa-mir-877-3p (MIRT036987)

    Block miRNA regulation of human, mouse, rat EEF2K using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EEF2K (see all 72):
    hsa-miR-3678-3p hsa-miR-3938 hsa-miR-371-5p hsa-miR-4325 hsa-miR-3613-3p hsa-miR-3148 hsa-miR-4293 hsa-miR-509-3-5p
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2
    endoplasmic reticulum1
    extracellular1
    golgi apparatus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS9144159
    GO:0005829cytosol TAS--

    Find genes that share ontologies with EEF2K           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for EEF2K About   (see all 12)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Insulin receptor signalling cascade
    Insulin receptor signalling cascade0.94
    Signaling by Insulin receptor0.80
    IRS-related events0.94
    PKB-mediated events0.41
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)0.92
    mTOR signalling0.39
    IRS-mediated signalling0.92
    mTORC1-mediated signalling0.00
    2Translation Insulin regulation of translation
    Translation Insulin regulation of translation0.59
    Regulation of lipid metabolism Insulin signaling generic cascades0.59
    3Translation Translation regulation by Alpha 1 adrenergic receptors
    Translation Translation regulation by Alpha 1 adrenergic receptors0.64
    4p70S6K Signaling
    p70S6K Signaling0.60
    5Signaling by GPCR
    Signal Transduction0.58


    Find genes that share SuperPaths with EEF2K           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for EEF2K
        p70S6K Signaling
    Insulin Receptor Pathway

    1 Cell Signaling Technology (CST) Pathway for EEF2K
        Translational Control

    3 GeneGo (Thomson Reuters) Pathways for EEF2K
        Translation Insulin regulation of translation
    Regulation of lipid metabolism Insulin signaling-generic cascades
    Translation Translation regulation by Alpha-1 adrenergic receptors

    4 BioSystems Pathways for EEF2K
        Translation Factors
    AMPK signaling
    mTOR signaling pathway
    Signaling mediated by p38-gamma and p38-delta


    1 Reactome Pathway for EEF2K
        S6K1 signalling


    1 Kegg Pathway  (Kegg details for EEF2K):
        Oxytocin signaling pathway

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    Interactions:

        GeneGlobe Interaction Network for EEF2K

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for EEF2K (O004182, 3 ENSP000002630264) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDK1P064932, 3MINT-6549314 MINT-6549429 MINT-6549466 I2D: score=1 
    RPS6KB2Q9UBS02, 3, ENSP000003084134MINT-15495 I2D: score=2 STRING: ENSP00000308413
    RPS6KA1Q154182, 3, ENSP000003632774MINT-17060 I2D: score=3 STRING: ENSP00000363277
    EEF2P136393, ENSP000003079404I2D: score=2 STRING: ENSP00000307940
    RPS6KB1P234433, ENSP000002255774I2D: score=2 STRING: ENSP00000225577
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006414translational elongation TAS9144159
    GO:0006468protein phosphorylation ----
    GO:0008286insulin receptor signaling pathway TAS--
    GO:0031952regulation of protein autophosphorylation IEA--
    GO:0046777protein autophosphorylation IDA9144159

    Find genes that share ontologies with EEF2K           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for EEF2K available from Tocris Bioscience    About this table
    CompoundAction CAS #
    NH 125CaM kinase III (eEF-2 kinase) inhibitor[278603-08-0]
    STO-609 acetateSelective CaM kinase kinase inhibitor[52029-86-4]
    A 484954CaM kinase III (eEF-2 kinase) inhibitor[142557-61-7]
    KN-93CaM kinase II inhibitor. Also K+ channel blocker (KV)[139298-40-1]
    Arcyriaflavin APotent cdk4/cyclin D1 and CaM Kinase II inhibitor. Antiviral agent (anti-HCMV)[118458-54-1]

    1 HMDB Compound for EEF2K    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Selected Novoseek inferred chemical compound relationships for EEF2K gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rottlerin 72.5 8 8307162 (1), 9056675 (1), 18712774 (1), 17164244 (1) (see all 5)
    rapamycin 64.3 11 15024086 (2), 11500364 (1), 15341530 (1), 16098202 (1) (see all 7)
    anisomycin 47.5 7 12171600 (3), 11500363 (2)
    atp 29.3 7 20300520 (2), 12416990 (1), 19244119 (1), 10913818 (1)
    nmda 23.4 2 16606372 (1), 16405506 (1)
    cyclic amp 19.9 3 1689374 (2)
    calcium 18.2 14 10373476 (1), 16606372 (1), 17187762 (1), 18988891 (1) (see all 8)
    tyrosine 12.3 5 9030224 (1), 8297101 (1), 15114688 (1), 8368481 (1) (see all 5)
    serine 9.7 1 11500364 (1)
    forskolin 9.6 3 12834812 (2), 1689374 (1)



    Find genes that share compounds with EEF2K           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for EEF2K gene: 
    NM_013302.3  

    Unigene Cluster for EEF2K:

    Eukaryotic elongation factor-2 kinase
    Hs.498892  [show with all ESTs]
    Unigene Representative Sequence: NM_013302
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263026(uc002dkh.3 uc002dki.3) ENST00000568269 ENST00000563555
    ENST00000561791
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat EEF2K
      QuantiFast Probe-based Assays in human, mouse, rat EEF2K

    Additional mRNA sequence: 

    AK022569.1 AK308757.1 BC032665.1 U93850.1 

    18 DOTS entries:

    DT.100695957  DT.100791745  DT.91721105  DT.95231461  DT.100702838  DT.120658706  DT.214535  DT.91649897 
    DT.100716784  DT.100810072  DT.120659007  DT.100791746  DT.95089310  DT.97820419  DT.120658785  DT.70104196 
    DT.86849745  DT.97787922 

    Selected AceView cDNA sequences (see all 139):

    AI087877 AI149514 CR621051 BM556214 BX641681 BQ012225 BF108667 AA744627 
    BF001312 BQ671518 BQ706210 BM769317 AU279717 AI041583 BU633308 CF528464 
    BG057770 AA211372 BQ672427 CB265331 AU185849 AW675420 CD515600 AW661897 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EEF2K expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCGAGACCCT
    EEF2K Expression
    About this image


    EEF2K expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Inner Cell Mass (Early Embryonic Tissues)
             Blimp1- mVenus and stella-ECFP genetically modified stem cells
    EEF2K Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EEF2K Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.498892
        Custom PCR Arrays for EEF2K
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for EEF2K gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Eef2k1 , 5 eukaryotic elongation factor-2 kinase1, 5 85.91(n)1
    90.19(a)1
      7 (64.95 cM)5
    136311  NM_001267711.11  NP_001254640.11 
     1208428315 
    chicken
    (Gallus gallus)
    Aves EEF2K1 eukaryotic elongation factor-2 kinase 74.25(n)
    78.9(a)
      416619  XM_004945301.1  XP_004945358.1 
    lizard
    (Anolis carolinensis)
    Reptilia EEF2K6
    eukaryotic elongation factor-2 kinase
    71(a)
    1 ↔ 1
    GL343846.1(54134-86501)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.186332 Xenopus laevis transcribed sequence with weak similarity more 80.58(n)    AW641430.1 
    zebrafish
    (Danio rerio)
    Actinopterygii eef2k1 elongation factor-2 kinase 66.31(n)
    69.51(a)
      437013  NM_001002740.1  NP_001002740.1 
    worm
    (Caenorhabditis elegans)
    Secernentea efk-11 , 3 Expression: embryo3
    efk-11
    63(a)3
    49.28(n)1
    45.79(a)1
      III(6237055-6240296)3
    1758711  NM_001027401.21  NP_001022572.11 


    ENSEMBL Gene Tree for EEF2K (if available)
    TreeFam Gene Tree for EEF2K (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for EEF2K gene
    ALPK12  

    Find genes that share paralogs with EEF2K           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for EEF2K (see all 1669)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0415344
    A colorectal adenocarcinoma sample4--see VAR_0415342 T M mis40--------
    rs1423692011,2
    --22215618(+) CAGCCA/TCCTGA 1 -- us2k10--------
    rs1924556291,2
    --22215797(+) ACCTTA/GCCCGG 1 -- us2k10--------
    rs1997013011,2
    --22215900(+) TTAAT-/AAAAAT 1 -- us2k10--------
    rs58161721,2
    C--22215903(+) ATAAAT/-ATTTG 1 -- us2k12Minor allele frequency- -:0.00CSA 4
    rs677892721,2
    C--22215904(+) TAAAA-/TTTTGC 1 -- us2k10--------
    rs1479038251,2
    C--22216088(+) ATGCTA/GATTGG 1 -- us2k10--------
    rs1812604901,2
    C--22217798(+) CGCGCA/GCCCTG 1 -- ut510--------
    rs1481494541,2
    --22217834(+) CCCCAA/GCTGCT 1 -- ut510--------
    rs1865053811,2
    --22217899(+) GGCCCA/GCCCGC 1 -- ut510--------

    HapMap Linkage Disequilibrium report for EEF2K (22217592 - 22300066 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for EEF2K (see all 17):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2714070CNV Deletion23290073
    nsv435668CNV Deletion17901297
    esv2662229CNV Deletion23128226
    dgv48n16CNV Insertion17901297
    nsv498860CNV Loss21111241
    nsv1764CNV Loss18451855
    dgv2647n71CNV Loss21882294
    nsv905598CNV Gain21882294
    nsv519813CNV Gain+Loss19592680
    dgv834e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): EEF2K
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing EEF2K
    DNA2.0 Custom Variant and Variant Library Synthesis for EEF2K

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606968    OMIM disorders: --


    Find genes that share disorders with EEF2K           About GenesLikeMe

    5 Novoseek inferred disease relationships for EEF2K gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glioblastoma 15.4 6 16540650 (5)
    glioma 14.5 2 14583488 (1), 19244119 (1)
    breast cancer 0 5 16648488 (1), 20300520 (1), 10408694 (1)
    tumors 0 3 16540650 (2), 19244119 (1)
    cancer 0 4 16540650 (2), 14583488 (1), 19244119 (1)

    Genetic Association Database (GAD): EEF2K
    Human Genome Epidemiology (HuGE) Navigator: EEF2K (2 documents)

    Export disorders for EEF2K gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EEF2K gene, integrated from 10 sources (see all 118):
    (articles sorted by number of sources associating them with EEF2K)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a new class of protein kinases represented by eukaryotic elongation factor-2 kinase. (PubMed id 9144159)1, 2, 3, 9 Ryazanov A.G.... Hait W.N. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    2. Mapping the functional domains of elongation factor-2 kinase. (PubMed id 11015200)1, 2, 9 Pavur K.S.... Ryazanov A.G. (Biochemistry 2000)
    3. Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398. (PubMed id 14709557)1, 2, 9 Browne G.J.... Proud C.G. (J. Biol. Chem. 2004)
    4. A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38delta. (PubMed id 11500363)1, 2, 9 Knebel A.... Cohen P. (EMBO J. 2001)
    5. Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase. (PubMed id 11500364)1, 2, 9 Wang X.... Proud C.G. (EMBO J. 2001)
    6. Identification of autophosphorylation sites in eukaryotic elongation factor-2 kinase. (PubMed id 22216903)1, 2 Pyr Dit Ruys S.... Proud C.G. (Biochem. J. 2012)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    8. cdc2-cyclin B regulates eEF2 kinase activity in a cell cycle- and amino acid-dependent manner. (PubMed id 18337751)1, 2 Smith E.M. and Proud C.G. (EMBO J. 2008)
    9. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    10. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 29904 HGNC: 24615 AceView: EEF2K Ensembl:ENSG00000103319 euGenes: HUgn29904
    ECgene: EEF2K Kegg: 29904 H-InvDB: EEF2K

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for EEF2K Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EEF2K Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for EEF2K gene:
    Search GeneIP for patents involving EEF2K

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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