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Aliases for EEF2 Gene

Aliases for EEF2 Gene

  • Eukaryotic Translation Elongation Factor 2 2 3
  • EF2 3 4 6
  • Polypeptidyl-TRNA Translocase 2 3
  • SCA26 3 6
  • EF-2 3 4
  • Elongation Factor 2 3
  • EEF-2 3

External Ids for EEF2 Gene

Previous HGNC Symbols for EEF2 Gene

  • EF2

Previous GeneCards Identifiers for EEF2 Gene

  • GC19M004066
  • GC19M003916
  • GC19M003927
  • GC19M003738

Summaries for EEF2 Gene

Entrez Gene Summary for EEF2 Gene

  • This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation. [provided by RefSeq, Jul 2008]

GeneCards Summary for EEF2 Gene

EEF2 (Eukaryotic Translation Elongation Factor 2) is a Protein Coding gene. Diseases associated with EEF2 include spinocerebellar ataxia 26. Among its related pathways are p70S6K Signaling and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include GTP binding and translation elongation factor activity. An important paralog of this gene is EFTUD2.

UniProtKB/Swiss-Prot for EEF2 Gene

  • Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome

Gene Wiki entry for EEF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EEF2 Gene

Genomics for EEF2 Gene

Regulatory Elements for EEF2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for EEF2 Gene

Start:
3,976,056 bp from pter
End:
3,985,469 bp from pter
Size:
9,414 bases
Orientation:
Minus strand

Genomic View for EEF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EEF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EEF2 Gene

Proteins for EEF2 Gene

  • Protein details for EEF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13639-EF2_HUMAN
    Recommended name:
    Elongation factor 2
    Protein Accession:
    P13639
    Secondary Accessions:
    • B2RMP5
    • D6W618
    • Q58J86

    Protein attributes for EEF2 Gene

    Size:
    858 amino acids
    Molecular mass:
    95338 Da
    Quaternary structure:
    • Component of the mRNA surveillance SURF complex, at least composed of ERF1, ERF3 (ERF3A or ERF3B), EEF2, UPF1/RENT1, SMG1, SMG8 and SMG9.

    Three dimensional structures from OCA and Proteopedia for EEF2 Gene

neXtProt entry for EEF2 Gene

Proteomics data for EEF2 Gene at MOPED

Post-translational modifications for EEF2 Gene

  • Diphthamide is 2-[3-carboxyamido-3-(trimethyl-ammonio)propyl]histidine. Diphthamide can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A, thus arresting protein synthesis (By similarity).
  • ISGylated.
  • Phosphorylation by EF-2 kinase completely inactivates EF-2; it requires prior phosphorylation by CDK2 at Ser-595 during mitotic prometaphase. Phosphorylation by CSK promotes SUMOylation, proteolytic cleavage, and nuclear translocation if the C-terminal fragment.
  • Proteolytically processed at two sites following phosphorylation by CSK.
  • SUMOytated following phosphorylation by CSK, promotes proteolytic cleavage.
  • Ubiquitination at Lys32, Lys42, Lys152, Lys159, Lys235, Lys239, Lys272, Lys275, Lys318, Lys333, Lys366, Lys386, Lys426, Lys481, Lys498, Lys512, Lys594, Lys638, Lys648, Lys688, and Lys845
  • Modification sites at PhosphoSitePlus

Other Protein References for EEF2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for EEF2 (eEF2)

No data available for DME Specific Peptides for EEF2 Gene

Domains for EEF2 Gene

Graphical View of Domain Structure for InterPro Entry

P13639

UniProtKB/Swiss-Prot:

EF2_HUMAN :
  • P13639
Domain:
  • Contains 1 tr-type G (guanine nucleotide-binding) domain.
Family:
  • Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
genes like me logo Genes that share domains with EEF2: view

No data available for Gene Families for EEF2 Gene

Function for EEF2 Gene

Molecular function for EEF2 Gene

GENATLAS Biochemistry:
eukaryotic translation elongation factor 2
UniProtKB/Swiss-Prot Function:
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome

Gene Ontology (GO) - Molecular Function for EEF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003746 translation elongation factor activity IEA --
GO:0003924 GTPase activity IEA --
GO:0005515 protein binding IPI 19417104
GO:0005525 GTP binding IEA --
GO:0008494 translation activator activity --
genes like me logo Genes that share ontologies with EEF2: view
genes like me logo Genes that share phenotypes with EEF2: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EEF2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for EEF2 Gene

Localization for EEF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EEF2 Gene

Cytoplasm. Nucleus. Note=Phosphorylation by CSK promotes cleavage and SUMOylation-dependent nuclear translocation of the C-terminal cleavage product. {ECO:0000269 PubMed:24648518}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EEF2 Gene COMPARTMENTS Subcellular localization image for EEF2 gene
Compartment Confidence
cytosol 4
golgi apparatus 3
cytoskeleton 2
nucleus 2
chloroplast 1
endoplasmic reticulum 1
endosome 1
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for EEF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005844 polysome IEA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with EEF2: view

Pathways for EEF2 Gene

genes like me logo Genes that share pathways with EEF2: view

Gene Ontology (GO) - Biological Process for EEF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0006184 obsolete GTP catabolic process --
GO:0006412 translation TAS --
GO:0006414 translational elongation TAS --
GO:0008219 cell death --
genes like me logo Genes that share ontologies with EEF2: view

Compounds for EEF2 Gene

(4) HMDB Compounds for EEF2 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
146-91-8
Guanosine triphosphate
  • 5'-GTP
86-01-1
Phosphate
  • NFB Orthophosphate
14265-44-2
Water
  • Dihydrogen oxide
7732-18-5

(4) Drugbank Compounds for EEF2 Gene

(47) Novoseek inferred chemical compound relationships for EEF2 Gene

Compound -log(P) Hits PubMed IDs
diphthamide 88.3 10
apup 88.3 1
sordarin 78 7
exotoxin-a 77.8 7
rapamycin 69.7 23
genes like me logo Genes that share compounds with EEF2: view

Transcripts for EEF2 Gene

Unigene Clusters for EEF2 Gene

Eukaryotic translation elongation factor 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EEF2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EEF2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d ^ 14 ^ 15 ^
SP1: -
SP2: - -
SP3: - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - - - - - - - -
SP5:
SP6: - - - - - - - - - - -
SP7: - - -
SP8:
SP9:

ExUns: 16a · 16b ^ 17a · 17b · 17c ^ 18
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: - - - - -
SP8: - -
SP9:

Relevant External Links for EEF2 Gene

GeneLoc Exon Structure for
EEF2
ECgene alternative splicing isoforms for
EEF2

Expression for EEF2 Gene

mRNA expression in normal human tissues for EEF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for EEF2 Gene

This gene is overexpressed in Lymph node (10.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EEF2 Gene

SOURCE GeneReport for Unigene cluster for EEF2 Gene Hs.515070

genes like me logo Genes that share expressions with EEF2: view

Expression partners for EEF2 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EEF2 Gene

Orthologs for EEF2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EEF2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EEF2 35
  • 90.75 (n)
  • 99.3 (a)
EEF2 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EEF2 35
  • 89.51 (n)
  • 99.53 (a)
EEF2 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eef2 35
  • 88.42 (n)
  • 99.07 (a)
Eef2 16
Eef2 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC100614367 35
  • 98.89 (n)
  • 99.78 (a)
EEF2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eef2 35
  • 88.46 (n)
  • 99.18 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 99 (a)
OneToMany
-- 36
  • 98 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia EEF2 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves EEF2 35
  • 85.63 (n)
  • 97.32 (a)
EEF2 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EEF2 36
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eef2.1 35
  • 79.02 (n)
  • 95.8 (a)
MGC76191 35
African clawed frog
(Xenopus laevis)
Amphibia eef2-prov 35
zebrafish
(Danio rerio)
Actinopterygii eef2b 35
  • 82.44 (n)
  • 92.89 (a)
zgc63584 35
eef2l2 36
  • 92 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9660 35
fruit fly
(Drosophila melanogaster)
Insecta Ef2b 37
  • 78 (a)
Ef2b 35
  • 73.1 (n)
  • 80.36 (a)
Ef2b 36
  • 80 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009441 35
  • 75.71 (n)
  • 80.71 (a)
worm
(Caenorhabditis elegans)
Secernentea eft-2 37
  • 78 (a)
K10C3.5 37
  • 28 (a)
eef-2 35
  • 71.59 (n)
  • 81.55 (a)
eef-2 36
  • 80 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EFT2 36
  • 67 (a)
OneToMany
EFT1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons LOS1 35
  • 62.93 (n)
  • 63.77 (a)
soybean
(Glycine max)
eudicotyledons Gma.10782 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6678 35
rice
(Oryza sativa)
Liliopsida Os01g0742200 35
  • 63.16 (n)
  • 64.11 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.5736 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11302 36
  • 75 (a)
ManyToMany
Species with no ortholog for EEF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for EEF2 Gene

ENSEMBL:
Gene Tree for EEF2 (if available)
TreeFam:
Gene Tree for EEF2 (if available)

Paralogs for EEF2 Gene

Paralogs for EEF2 Gene

Selected SIMAP similar genes for EEF2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with EEF2: view

Variants for EEF2 Gene

Sequence variations from dbSNP and Humsavar for EEF2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs13953 -- 3,976,401(+) GTGTT(A/G)TGGTT utr-variant-3-prime
rs36525 -- 3,980,826(-) CCCGG(C/T)GGCCG intron-variant
rs36526 Likely benign 3,979,410(+) ATGAT(A/G)TGCTC synonymous-codon, reference
rs36527 Likely benign 3,977,488(+) CTGGC(A/G)TAGAG synonymous-codon, reference
rs1445850 -- 3,984,770(-) ATCCC(C/G)TTTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EEF2 Gene

Variant ID Type Subtype PubMed ID
nsv833715 CNV Loss 17160897
nsv910780 CNV Loss 21882294
dgv3665n71 CNV Loss 21882294
nsv910783 CNV Loss 21882294
nsv910786 CNV Loss 21882294
dgv3666n71 CNV Loss 21882294
dgv3667n71 CNV Loss 21882294
esv1001715 CNV Deletion 20482838
dgv3668n71 CNV Gain 21882294
nsv910794 CNV Loss 21882294
nsv910796 CNV Gain 21882294
nsv2392 CNV Insertion 18451855

Relevant External Links for EEF2 Gene

HapMap Linkage Disequilibrium report
EEF2
Human Gene Mutation Database (HGMD)
EEF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EEF2 Gene

Disorders for EEF2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for EEF2 Gene in MalaCards »

(1) Diseases for EEF2 Gene including...

(1) OMIM Diseases for EEF2 Gene (130610)

UniProtKB/Swiss-Prot

EF2_HUMAN
  • Spinocerebellar ataxia 26 (SCA26) [MIM:609306]: A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. {ECO:0000269 PubMed:23001565}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for EEF2 Gene

(9) Novoseek inferred disease relationships for EEF2 Gene

Disease -log(P) Hits PubMed IDs
diphtheria 83.4 30
intoxication 35 3
shock 14.5 9
cancer 1.96 4
glioma 0 1

Relevant External Links for EEF2

Genetic Association Database (GAD)
EEF2
Human Genome Epidemiology (HuGE) Navigator
EEF2
genes like me logo Genes that share disorders with EEF2: view

No data available for Genatlas for EEF2 Gene

Publications for EEF2 Gene

  1. Complete sequence of the coding region of human elongation factor 2 (EF-2) by enzymatic amplification of cDNA from human ovarian granulosa cells. (PMID: 2610926) Rapp G. … Heinz K. (Biol. Chem. Hoppe-Seyler 1989) 2 3 4
  2. Cloning and sequence analysis of a cDNA from human ovarian granulosa cells encoding the C-terminal part of human elongation factor 2. (PMID: 2840927) Rapp G. … Scheit K.H. (Biol. Chem. Hoppe-Seyler 1988) 3 4
  3. Chromosomal assignment of the gene for human elongation factor 2. (PMID: 6427766) Kaneda Y. … Okada Y. (Proc. Natl. Acad. Sci. U.S.A. 1984) 2 3
  4. Proteomic identification of proteins conjugated to ISG15 in mouse and human cells. (PMID: 16139798) Giannakopoulos N.V. … Zhang D.E. (Biochem. Biophys. Res. Commun. 2005) 3 4
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4

Products for EEF2 Gene

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