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EEF2 Gene

protein-coding GIFtS: 68

GC19M003927

eukaryotic translation elongation factor 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: EF2)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EEF-2 ^¹, ²
EF-2 ^³
EF2 ^², ³, ⁵

Descriptions
eukaryotic translation elongation factor 2 ^²
polypeptidyl-tRNA translocase ^²

External Ids
HGNC: 3214¹
Entrez Gene: 1938²
UniProtKB: P13639³
Ensembl: ENSG00000167658⁷

Search outside databases for aliases for EEF2 gene

Previous GC identifers: GC19M004066 GC19M003916

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for EEF2:

This gene encodes a member of the GTP-binding translation elongation factor family. This protein is

an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the

nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely

inactivated by EF-2 kinase phosporylation. [provided by RefSeq]

UniProtKB/Swiss-Prot: EF2_HUMAN, P13639

Function: This protein promotes the GTP-dependent translocation of the nascent protein chain from

the A-site to the P-site of the ribosome

Gene Wiki entry for EEF2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the EEF2 gene

Entrez Gene cytogenetic band: 19pter-q12 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19pter-q12

EEF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M003927: (about GC identifiers)

Start:	3,927,054 bp from pter
End:	3,936,461 bp from pter
Size:	9,408 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000019.8 NT_011255.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: EF2_HUMAN, P13639 (See protein sequence)

Recommended Name: Elongation factor 2

Size: 858 amino acids; 95338 Da

Subunit: Component of the mRNA surveillance SURF complex, at least composed of ERF1, ERF3 (ERF3A or

ERF3B), EEF2, UPF1/RENT1, SMG1, SMG8 and SMG9

Subcellular location: Cytoplasm

Secondary accessions: Q58J86

Post-translational modifications:

Phosphorylation by EF-2 kinase completely inactivates EF-2¹

Diphthamide is 2-[3-carboxyamido-3-(trimethyl-ammonio)propyl]histidine. Diphthamide can be

ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001952.1

ENSEMBL proteins:

ENSP00000307940

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (EEF2)
	Human Recombinant Proteins from Abnova (EEF2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--

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Antibodies for EEF2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	R&D Systems Antibodies for EEF2 (eEF-2)
	Antibodies from Abcam (EEF2), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for EEF2

Assays for EEF2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P13639

ProtoNet protein and cluster: P13639

2 Blocks protein families:

IPB000640 Elongation factor G

IPB005517 Elongation factor G

UniProtKB/Swiss-Prot: EF2_HUMAN, P13639

Similarity: Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (EEF2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001961

Applied Biosystems Silencer® siRNAs for EEF2

Sigma-Aldrich siRNA for EEF2

Sigma-Aldrich shRNA for EEF2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001961
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001961
untagged cDNA clone in CMV expression vector: NM_001961

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001961

UniProtKB/Swiss-Prot: EF2_HUMAN, P13639

Function: This protein promotes the GTP-dependent translocation of the nascent protein chain from

the A-site to the P-site of the ribosome

Genatlas biochemistry entry for EEF2:

eukaryotic translation elongation factor 2

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003746	translation elongation factor activity	IEA	--
GO:0003924	GTPase activity	IEA	--
GO:0005515	protein binding	IPI	17220478
GO:0005525	GTP binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Gene Network Central^TM Interacting Genes and Proteins Network for EEF2

5/252 Interacting proteins for EEF2 (ENSP00000307940³ P13639^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 252 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ENSG00000161016	P62917²	STRING (score=.976) MINT-6542674
RPL10AP9	P62906²	STRING (score=.91) MINT-6542674
RPL11	P62913²	STRING (score=.968) MINT-6542674
RPL13P12	P26373²	STRING (score=.921) MINT-6542674
RPL18	Q07020²	STRING (score=.949) MINT-6542674

About this table

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006414	translational elongation	EXP	15189156

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for EEF2

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for EEF2
10/29 Novoseek chemical compound relationships for EEF2 gene (see all 29 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
diphthamide	89.10	16	1353910 (3), 15485916 (2), 1730643 (2), 14756556 (1) (see all 6)
apup	88.69	1	7833807 (1)
exotoxin-a	76.21	9	1353910 (1), 10861457 (1), 8692916 (1), 1719985 (1) (see all 5)
ricin	67.42	6	1425176 (1), 7999776 (1), 8318952 (1), 8253723 (1)
nad+	53.89	6	8692916 (1), 8172890 (1), 14756556 (1), 16817779 (1) (see all 5)
gtp	51.83	21	7805855 (4), 8617259 (3), 2318846 (2), 1511751 (1) (see all 11)
gdp	49.26	8	7805855 (2), 8617259 (1), 9032056 (1), 1420308 (1) (see all 6)
glyceraldehyde 3-phosphate	41.76	6	9398045 (1), 18161940 (1), 18762224 (1), 15660415 (1) (see all 6)
adp	41.29	23	16142694 (5), 14756556 (3), 1353910 (2), 11037133 (2) (see all 10)
poly u	30.49	2	2311763 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (EEF2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001961

Sigma-Aldrich siRNA for EEF2

Sigma-Aldrich shRNA for EEF2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001961

REFSEQ mRNAs for EEF2 gene:

NM_001961.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001961

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001961
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001961
                                 untagged cDNA clone in CMV expression vector: NM_001961

Additional cDNA sequence:

AK297398.1 AK298498.1 AK299225.1 AY942181.1 BC006547.2 BC024689.1 BC126259.1 BC136313.1

CR596005.1 CR598660.1 CR602709.1 CR608809.1 CR616093.1 M19997.1 X51466.1 Z11692.1

24/63 DOTS entries (see all 63 ):

DT.95256406 DT.92466824 DT.92466830 DT.95256420 DT.452835 DT.91978289 DT.100041772 DT.100867128

DT.92047640 DT.92371227 DT.87016867 DT.100855407 DT.100658617 DT.75134632 DT.121430847 DT.92466819

DT.92466812 DT.121430864 DT.121430955 DT.92466810 DT.97864766 DT.91881089 DT.91986754 DT.92334137

24/1223 AceView cDNA sequences (see all 1223 ):

BM756524 AI458575 BG770149 BE733066 BU527472 BI754899 BP365468 AI816599

BM771580 BM841061 CD106615 BP353058 CR616093 BP871197 AA357426 BP356357

CN482704 CA434489 BE140740 CN483057 BF346066 BC024689 BM799812 BP357839

highest scoring ESTs for EEF2:

AL527259 AU100434 AU117038 BE295332 BF527524 BF674019 BG031631 BG716091 BG826545 BM803346

Unigene Cluster for EEF2:

Eukaryotic translation elongation factor 2

Hs.515070 [show with all ESTs]

Unigene Representative Sequence: NM_001961

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for EEF2 (see all 9 )

ExUns:	1a	·	1b	^	2	^	3a	·	3b	·	3c	^	4	^	5	^	6a	·	6b	·	6c	·	6d	^	7	^	8	^	9a	·	9b	^	10a	·	10b	^	11	^	12	^	13a	·	13b	·	13c	·	13d	^	14	^	15	^
SP1:																	-
SP2:					-												-
SP3:					-				-		-		-		-		-		-		-		-		-		-		-		-		-
SP4:					-						-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-
SP5:

ExUns:	16a	·	16b	^	17a	·	17b	·	17c	^	18
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for EEF2

1 Ensembl transcript including schematic representation:

ENST00000309311

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

EEF2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for EEF2

¹ / ² / ³

6 probe-sets matching EEF2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36587_at²^{, 3}	U95-A	1	1.00	1.00	0.91	0.99	Z11692	0.80	0.80	0.80	1
87875_at²^{, 3}	U95-E	1	0.69	1.00	0.94	1.01	AI352429	0.40	1.00	0.76	1
200094_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI004246	0.40	1.00	0.76	1
204102_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001961	0.40	0.67	0.55	1
200094_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
204102_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AGCACCTCCA

SOURCE GeneReport for Unigene cluster: Hs.515070
Expression variation in blood from EXPOLDB for EEF2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for EEF2 gene from 5/25 species (see all 25 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	EEF2¹	--	eukaryotic translation elongation factor 2	87.07(n) 95.49(a)	476744 XM_533949.2 XP_533949.2
cow (Bos taurus)	EEF2¹	--	eukaryotic translation elongation factor 2	90.75(n) 99.3(a)	281138 NM_001075121.1 NP_001068589.1
rat (Rattus norvegicus)	Eef2¹	--	eukaryotic translation elongation factor 2	88.46(n) 99.18(a)	29565 NM_017245.2 NP_058941.1
mouse (Mus musculus)	Eef2^{1, 5}	10⁵	eukaryotic translation elongation factor 2^{1, 5}	88.42(n)¹ 99.07(a)¹	13629¹ NM_007907.1¹ NP_031933.1¹ AK028938⁵ AK032997⁵ (see all 371)
chicken (Gallus gallus)	EEF2¹	--	eukaryotic translation elongation factor 2	85.63(n) 97.32(a)	396325 NM_205368.1 NP_990699.1

About this table Species with no ortholog for EEF2

ENSEMBL Gene Tree for EEF2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for EEF2 gene

ENSG00000205242² EFTUD1² EFTUD2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/85 NCBI SNPs in EEF2 are shown (see all 85 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 48)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs3170368^1,2	A,C,F,H	3927321(-)	`ACTTAA/CTGGGC`	1	--	ut3¹ ese³		6		EA MN EU WA	1348
--	rs7251017^1,2	A,C,F,H	3936576(+)	`TGTCCA/C/TCCCGC`	1	--	ng3¹ tfbs³		4		EU EA WA	416
	rs2230567^1,2	C,F,H	3927441(-)	`CTCCCC/TTGAGA`	1	--	ut3¹ ese³		5		MN EU EA WA	452
	rs10418537^1,2	C,F,H	3937003(+)	`ttaggG/Agtttt`	1	--	ng3¹		4		EU EA WA	404
	rs2230566^1,2	C,F,H	3927549(-)	`TAGGCG/AGCCCT`	1	--	ut3¹ ese³		9		MN EU EA WA NA	786
	rs3167726^1,2	A,H	3927142(-)	`GATTTC/TTAGCA`	1	--	ut3¹ ese³		5		MN EU EA WA	600
	rs3760896^1,2	F,H	3937468(+)	`ccaacC/Tcgctg`	1	--	ng3¹		4		EU EA WA	418
	rs3189553^1,2	F	3927113(-)	`GTGTCA/CCCATG`	1	--	ut3¹ ese³		1		MN	184
--	rs11665963^1,2	C	3938441(+)	`ggagaA/Cccgct`	1	--	ng3¹		0	--	--	--	--
	rs36526^1,2	A,C,F,H	3930408(+)	`ATGATG/ATGCTC`	1	H/H	syn¹ ese³		13		EA NA EU WA	1154

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HapMap Linkage Disequilibrium images for EEF2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 130610

9 Novoseek disease relationships for EEF2 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
diphtheria	84.36	39	14756556 (3), 16142694 (2), 2109323 (1), 1939154 (1) (see all 27)
intoxication	37.07	4	2140788 (1), 9430652 (1), 9398176 (1)
shock	13.66	11	8361337 (1), 12641431 (1), 18762224 (1), 15749383 (1) (see all 8)
glioma	2.83	1	11358819 (1)
cancer	0.00	3	18161940 (1), 11254220 (1), 19244119 (1)
carcinoma	0.00	2	15534876 (1)
breast cancer	0.00	2	16648488 (1), 15289310 (1)
tumors	0.00	1	15660415 (1)
alzheimers disease	0.00	3	1331687 (2), 16098202 (1)

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/220 PubMed articles for EEF2 gene (see all 220 ):

Complete sequence of the coding region of human elongation factor 2 (EF-2) by enzymatic amplification of cDNA from human ovarian granulosa cells. (PubMed id 2610926)^{2, 3, 4} Rapp G.... Heinz K. (1989)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{3, 4} Beausoleil S.A.... Gygi S.P. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC. (PubMed id 16097034)^{3, 4} Gevaert K.... Vandekerckhove J. (2005)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)^{3, 4} Beausoleil S.A....Gygi S.P. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Construction of a plasmid containing the complete coding region of human elongation factor 2. (PubMed id 1596361)^{3, 4} Hanes J.... Scheit K.H. (1992)
Cloning and sequence analysis of a cDNA from human ovarian granulosa cells encoding the C-terminal part of human elongation factor 2. (PubMed id 2840927)^{3, 4} Rapp G.... Scheit K.H. (1988)
Chromosomal assignment of the gene for human elongation factor 2. (PubMed id 6427766)^{2, 3} Kaneda Y....Okada Y. (1984)
Regulation of elongation factor-2 by multisite phosphorylation. (PubMed id 8386634)^{1, 3} Redpath N.T....Proud C.G. (1993)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 1938	HGNC: 3214	AceView: EEF2	Ensembl:ENSG00000167658	euGenes: HUgn1938
ECgene: EEF2	H-InvDB: EEF2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for EEF2	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for EEF2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for EEF2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for EEF2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for EEF2		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for EEF2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (EEF2)
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Search Tocris compounds for EEF2

	Drugs for EEF2
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for EEF2

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
EEF2 Gene at Home site.
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EEF2 Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for EEF2

Summaries
for EEF2

Genomic Location
for EEF2

Proteins
for EEF2

Protein Domains/
Families
for EEF2

Gene Function
for EEF2

Pathways & Interactions
for EEF2

Drugs & Compounds
for EEF2

Transcripts
for EEF2

Expression
for EEF2

Orthologs
for EEF2

Paralogs
for EEF2

SNPs/Variants
for EEF2

Disorders & Mutations
for EEF2

Medical News
for EEF2

Publications
for EEF2

Search for EEF2

Genome Databases showing EEF2

Other Databases showing EEF2

Specialized Databases showing EEF2

Licensable Technologies
for EEF2

Services
for EEF2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

EEF2 Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor EEF2

Summariesfor EEF2

Genomic Locationfor EEF2

Proteinsfor EEF2

Protein Domains/Familiesfor EEF2

Gene Functionfor EEF2

Pathways & Interactionsfor EEF2

Drugs & Compoundsfor EEF2

Transcriptsfor EEF2

Expression for EEF2

Orthologsfor EEF2

Paralogsfor EEF2

SNPs/Variantsfor EEF2

Disorders & Mutationsfor EEF2

Medical Newsfor EEF2

Publicationsfor EEF2

Search for EEF2

Genome Databases showing EEF2

Other Databases showing EEF2

Specialized Databases showing EEF2

Licensable Technologiesfor EEF2

Servicesfor EEF2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for EEF2

Summaries
for EEF2

Genomic Location
for EEF2

Proteins
for EEF2

Protein Domains/
Families
for EEF2

Gene Function
for EEF2

Pathways & Interactions
for EEF2

Drugs & Compounds
for EEF2

Transcripts
for EEF2

Expression
for EEF2

Orthologs
for EEF2

Paralogs
for EEF2

SNPs/Variants
for EEF2

Disorders & Mutations
for EEF2

Medical News
for EEF2

Publications
for EEF2

Licensable Technologies
for EEF2

Services
for EEF2