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Aliases for EEF2 Gene

Aliases for EEF2 Gene

  • Eukaryotic Translation Elongation Factor 2 2 3 5
  • Polypeptidyl-TRNA Translocase 2 3
  • EF-2 3 4
  • EF2 3 4
  • Elongation Factor 2 3
  • EEF-2 3
  • SCA26 3

External Ids for EEF2 Gene

Previous HGNC Symbols for EEF2 Gene

  • EF2

Previous GeneCards Identifiers for EEF2 Gene

  • GC19M004066
  • GC19M003916
  • GC19M003927
  • GC19M003738

Summaries for EEF2 Gene

Entrez Gene Summary for EEF2 Gene

  • This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation. [provided by RefSeq, Jul 2008]

GeneCards Summary for EEF2 Gene

EEF2 (Eukaryotic Translation Elongation Factor 2) is a Protein Coding gene. Diseases associated with EEF2 include Spinocerebellar Ataxia 26 and Diphtheria. Among its related pathways are mTOR signaling pathway (KEGG) and Immune System. GO annotations related to this gene include poly(A) RNA binding and protein kinase binding. An important paralog of this gene is EFTUD2.

UniProtKB/Swiss-Prot for EEF2 Gene

  • Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.

Gene Wiki entry for EEF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EEF2 Gene

Genomics for EEF2 Gene

Regulatory Elements for EEF2 Gene

Enhancers for EEF2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F004042 0.4 ENCODE 12.1 -57.7 -57717 2.1 PAF1 ESRRA MAZ ZNF687 SIN3A ZHX2 DPF2 MBD2 HIC1 CTBP1 ZBTB7A EEF2 ENSG00000267980 NFIC ENSG00000268670 GC19M003988
GH19F003849 0.2 ENCODE 11.4 +136.1 136112 0.2 CTCF MAZ PKNOX1 CREB3L1 BHLHE40 REST RAD21 ZKSCAN1 JUND SCRT2 ATCAY MIR637 DAPK3 EEF2 PIR53050 GC19P003837
GH19F003857 0.2 ENCODE 11.3 +127.6 127642 0.1 SCRT1 RFX1 RFX3 RFXANK SCRT2 CEBPB BMI1 REST CREM RFX5 ATCAY EEF2 PIR53050 ZFR2
GH19F003852 1.1 ENCODE 11.3 +132.7 132682 0.1 KLF17 RAD21 RFX5 ZNF335 ZNF121 SMARCC2 RCOR1 FOS EGR2 ZNF654 CACTIN ATCAY EEF2 ZNF77 PIR53050 GC19P003837
GH19F004129 1 Ensembl ENCODE 11.2 -145.7 -145695 2.4 ATF1 PKNOX1 ARNT ARID4B SIN3A ZNF48 ZNF121 GATA2 ZNF548 FOS CACTIN CREB3L3 SIRT6 ANKRD24 CACTIN-AS1 APBA3 EEF2 FSD1 TMIGD2 ENSG00000269807
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around EEF2 on UCSC Golden Path with GeneCards custom track

Promoters for EEF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000640779 169 2201 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for EEF2 Gene

Chromosome:
19
Start:
3,976,056 bp from pter
End:
3,985,469 bp from pter
Size:
9,414 bases
Orientation:
Minus strand

Genomic View for EEF2 Gene

Genes around EEF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EEF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EEF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EEF2 Gene

Proteins for EEF2 Gene

  • Protein details for EEF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13639-EF2_HUMAN
    Recommended name:
    Elongation factor 2
    Protein Accession:
    P13639
    Secondary Accessions:
    • B2RMP5
    • D6W618
    • Q58J86

    Protein attributes for EEF2 Gene

    Size:
    858 amino acids
    Molecular mass:
    95338 Da
    Quaternary structure:
    • Component of the mRNA surveillance SURF complex, at least composed of ERF1, ERF3 (ERF3A or ERF3B), EEF2, UPF1/RENT1, SMG1, SMG8 and SMG9 (PubMed:19417104). Interacts with RBPMS2 (PubMed:25064856).

    Three dimensional structures from OCA and Proteopedia for EEF2 Gene

neXtProt entry for EEF2 Gene

Post-translational modifications for EEF2 Gene

  • Diphthamide is 2-[3-carboxyamido-3-(trimethyl-ammonio)propyl]histidine. Diphthamide can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A, thus arresting protein synthesis (By similarity).
  • ISGylated.
  • Phosphorylation by EF-2 kinase completely inactivates EF-2; it requires prior phosphorylation by CDK2 at Ser-595 during mitotic prometaphase. Phosphorylation by CSK promotes SUMOylation, proteolytic cleavage, and nuclear translocation if the C-terminal fragment.
  • Proteolytically processed at two sites following phosphorylation by CSK.
  • SUMOylated following phosphorylation by CSK, promotes proteolytic cleavage.
  • Ubiquitination at Lys 32, Lys 42, Lys 152, Lys 235, Lys 239, Lys 272, Lys 275, Lys 318, Lys 333, Lys 366, Lys 386, Lys 426, Lys 481, Lys 498, Lys 594, Lys 648, Lys 688, and Lys 845
  • Modification sites at PhosphoSitePlus

Other Protein References for EEF2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for EEF2 (EEF2)

No data available for DME Specific Peptides for EEF2 Gene

Domains & Families for EEF2 Gene

Graphical View of Domain Structure for InterPro Entry

P13639

UniProtKB/Swiss-Prot:

EF2_HUMAN :
  • Contains 1 tr-type G (guanine nucleotide-binding) domain.
  • Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
Domain:
  • Contains 1 tr-type G (guanine nucleotide-binding) domain.
Family:
  • Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
genes like me logo Genes that share domains with EEF2: view

No data available for Gene Families for EEF2 Gene

Function for EEF2 Gene

Molecular function for EEF2 Gene

GENATLAS Biochemistry:
eukaryotic translation elongation factor 2
UniProtKB/Swiss-Prot Function:
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.

Gene Ontology (GO) - Molecular Function for EEF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IEA --
GO:0003723 RNA binding IEA --
GO:0003746 translation elongation factor activity IEA --
GO:0003924 GTPase activity IBA --
GO:0005515 protein binding IPI 19417104
genes like me logo Genes that share ontologies with EEF2: view
genes like me logo Genes that share phenotypes with EEF2: view

Human Phenotype Ontology for EEF2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

miRNA for EEF2 Gene

miRTarBase miRNAs that target EEF2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for EEF2 Gene

Localization for EEF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EEF2 Gene

Cytoplasm. Nucleus. Note=Phosphorylation by CSK promotes cleavage and SUMOylation-dependent nuclear translocation of the C-terminal cleavage product. {ECO:0000269 PubMed:24648518}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EEF2 Gene COMPARTMENTS Subcellular localization image for EEF2 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
plasma membrane 5
cytoskeleton 2
golgi apparatus 2
mitochondrion 2
chloroplast 1
endoplasmic reticulum 1
endosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for EEF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 21630459
GO:0005737 cytoplasm IDA 25064856
GO:0005829 cytosol IEA,TAS --
GO:0005844 polysome IEA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with EEF2: view

Pathways & Interactions for EEF2 Gene

genes like me logo Genes that share pathways with EEF2: view

Pathways by source for EEF2 Gene

SIGNOR curated interactions for EEF2 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for EEF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0002931 response to ischemia IEA --
GO:0003009 skeletal muscle contraction IEA --
GO:0006412 translation IEA --
GO:0006414 translational elongation IEA,TAS --
genes like me logo Genes that share ontologies with EEF2: view

Drugs & Compounds for EEF2 Gene

(34) Drugs for EEF2 Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Guanosine diphosphate Experimental Pharma Target 0
Diphthamide Experimental Pharma Target 0
Adenosine-5-Diphosphoribose Experimental Pharma Target 0
N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE Experimental Pharma Target 0

(21) Additional Compounds for EEF2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
genes like me logo Genes that share compounds with EEF2: view

Transcripts for EEF2 Gene

Unigene Clusters for EEF2 Gene

Eukaryotic translation elongation factor 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EEF2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d ^ 14 ^ 15 ^
SP1: -
SP2: - -
SP3: - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - - - - - - - -
SP5:
SP6: - - - - - - - - - - -
SP7: - - -
SP8:
SP9:

ExUns: 16a · 16b ^ 17a · 17b · 17c ^ 18
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: - - - - -
SP8: - -
SP9:

Relevant External Links for EEF2 Gene

GeneLoc Exon Structure for
EEF2
ECgene alternative splicing isoforms for
EEF2

Expression for EEF2 Gene

mRNA expression in normal human tissues for EEF2 Gene

Protein differential expression in normal tissues from HIPED for EEF2 Gene

This gene is overexpressed in Lymph node (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EEF2 Gene



Protein tissue co-expression partners for EEF2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EEF2 Gene:

EEF2

SOURCE GeneReport for Unigene cluster for EEF2 Gene:

Hs.515070
genes like me logo Genes that share expression patterns with EEF2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EEF2 Gene

Orthologs for EEF2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EEF2 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 99 (a)
OneToMany
-- 35
  • 98 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia EEF2 35
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EEF2 35
  • 99 (a)
OneToOne
LOC100614367 34
  • 98.89 (n)
cow
(Bos Taurus)
Mammalia EEF2 34 35
  • 90.75 (n)
dog
(Canis familiaris)
Mammalia EEF2 34 35
  • 89.51 (n)
rat
(Rattus norvegicus)
Mammalia Eef2 34
  • 88.46 (n)
mouse
(Mus musculus)
Mammalia Eef2 34 16 35
  • 88.42 (n)
chicken
(Gallus gallus)
Aves EEF2 34 35
  • 85.63 (n)
lizard
(Anolis carolinensis)
Reptilia EEF2 35
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eef2.1 34
  • 79.02 (n)
MGC76191 34
African clawed frog
(Xenopus laevis)
Amphibia eef2-prov 34
zebrafish
(Danio rerio)
Actinopterygii eef2l2 35
  • 92 (a)
OneToOne
eef2b 34
  • 82.44 (n)
zgc63584 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9660 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009441 34
  • 75.71 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ef2b 36 34 35
  • 73.1 (n)
worm
(Caenorhabditis elegans)
Secernentea eft-2 36
  • 78 (a)
eef-2 34 35
  • 71.59 (n)
K10C3.5 36
  • 28 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EFT2 35
  • 67 (a)
OneToMany
EFT1 37
thale cress
(Arabidopsis thaliana)
eudicotyledons LOS1 34
  • 62.93 (n)
soybean
(Glycine max)
eudicotyledons Gma.10782 34
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6678 34
rice
(Oryza sativa)
Liliopsida Os01g0742200 34
  • 63.16 (n)
wheat
(Triticum aestivum)
Liliopsida Ta.5736 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11302 35
  • 75 (a)
ManyToMany
Species where no ortholog for EEF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for EEF2 Gene

ENSEMBL:
Gene Tree for EEF2 (if available)
TreeFam:
Gene Tree for EEF2 (if available)

Paralogs for EEF2 Gene

Paralogs for EEF2 Gene

(3) SIMAP similar genes for EEF2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with EEF2: view

Variants for EEF2 Gene

Sequence variations from dbSNP and Humsavar for EEF2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs587777052 Spinocerebellar ataxia 26 (SCA26) [MIM:609306], Pathogenic 3,978,099(+) TGTTG(G/T)GGGAC reference, missense
rs36526 Likely benign 3,979,410(+) ATGAT(A/G)TGCTC reference, synonymous-codon
rs36527 Likely benign 3,977,488(+) CTGGC(A/G)TAGAG reference, synonymous-codon
rs10407909 -- 3,984,804(+) AAATA(A/C)CGGGG intron-variant
rs10418537 -- 3,986,005(+) ttagg(A/G)gtttt upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for EEF2 Gene

Variant ID Type Subtype PubMed ID
esv1001715 CNV deletion 20482838
nsv2392 CNV insertion 18451855
nsv833715 CNV loss 17160897
nsv953949 CNV deletion 24416366

Variation tolerance for EEF2 Gene

Residual Variation Intolerance Score: 0.879% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.37; 8.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EEF2 Gene

Human Gene Mutation Database (HGMD)
EEF2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
EEF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EEF2 Gene

Disorders for EEF2 Gene

MalaCards: The human disease database

(7) MalaCards diseases for EEF2 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
spinocerebellar ataxia 26
  • spinocerebellar ataxia type 26
diphtheria
  • corynebacterium infection
pancoast tumor
  • malignant superior sulcus tumor
myotonic dystrophy 2
  • myotonic dystrophy type 2
fusariosis
  • fusarium infection
- elite association - COSMIC cancer census association via MalaCards
Search EEF2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

EF2_HUMAN
  • Spinocerebellar ataxia 26 (SCA26) [MIM:609306]: A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. {ECO:0000269 PubMed:23001565}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for EEF2

Genetic Association Database (GAD)
EEF2
Human Genome Epidemiology (HuGE) Navigator
EEF2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EEF2
genes like me logo Genes that share disorders with EEF2: view

No data available for Genatlas for EEF2 Gene

Publications for EEF2 Gene

  1. Complete sequence of the coding region of human elongation factor 2 (EF-2) by enzymatic amplification of cDNA from human ovarian granulosa cells. (PMID: 2610926) Rapp G. … Heinz K. (Biol. Chem. Hoppe-Seyler 1989) 2 3 4 64
  2. Homodimerization of RBPMS2 through a new RRM-interaction motif is necessary to control smooth muscle plasticity. (PMID: 25064856) Sagnol S. … de Santa Barbara P. (Nucleic Acids Res. 2014) 3 4 64
  3. Identification and characterization of a novel evolutionarily conserved lysine-specific methyltransferase targeting eukaryotic translation elongation factor 2 (eEF2). (PMID: 25231979) Davydova E. … Falnes P.O. (J. Biol. Chem. 2014) 3 4 64
  4. C-terminal Src kinase (Csk)-mediated phosphorylation of eukaryotic elongation factor 2 (eEF2) promotes proteolytic cleavage and nuclear translocation of eEF2. (PMID: 24648518) Yao Q. … Guo L. (J. Biol. Chem. 2014) 3 4 64
  5. Phosphorylation of eukaryotic elongation factor 2 (eEF2) by cyclin A-cyclin-dependent kinase 2 regulates its inhibition by eEF2 kinase. (PMID: 23184662) Hizli A.A. … Clurman B.E. (Mol. Cell. Biol. 2013) 3 4 64

Products for EEF2 Gene

Sources for EEF2 Gene

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