EEF2 Gene
protein-coding GIFtS: 69
GCID: GC19M003976
|
|
eukaryotic translation elongation factor 2
(Previous symbol: EF2)
| |
Aliases
for EEF2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Eukaryotic Translation Elongation Factor 21 2 | | EF21 2 3 5 | | EEF-21 2 | | EF-22 3 | | Elongation Factor 22 | | Polypeptidyl-TRNA Translocase2 |
Export aliases for EEF2 gene to outside databasesPrevious GC identifers: GC19M004066 GC19M003916 GC19M003927 GC19M003738 |
Summaries
for EEF2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for EEF2:
This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factorfor protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to theP-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation. (provided by RefSeq, Jul2008)
UniProtKB/Swiss-Prot: EF2_HUMAN, P13639Function: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, theribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formedA-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes thecoordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Gene Wiki entry for EEF2
|
Genomic Views
for EEF2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011255.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the EEF2 gene promoter:
TBP Sp1 p53 c-Myb STAT5A C/EBPalpha YY1
Other transcription factors
Search SABiosciences Chromatin IP Primers for EEF2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EEF2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3EEF2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M003976: view genomic region
(about GC identifiers)
Start:
|
3,976,054 bp from pter |
End:
|
3,985,461 bp from pter |
Size:
|
9,408 bases |
Orientation:
|
minus strand |
|
Proteins
for EEF2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: EF2_HUMAN, P13639 (See
protein sequence)Recommended Name: Elongation factor 2 Size: 858 amino acids; 95338 Da
Subunit: Component of the mRNA surveillance SURF complex, at least composed of ERF1, ERF3 (ERF3A or ERF3B), EEF2,UPF1/RENT1, SMG1, SMG8 and SMG9
Subcellular location: Cytoplasm
Secondary accessions: B2RMP5 D6W618 Q58J86Explore the universe of human proteins at neXtProt for EEF2: NX_P13639
Post-translational modifications:
Phosphorylation by EF-2 kinase completely inactivates EF-21
Diphthamide is 2-[3-carboxyamido-3-(trimethyl-ammonio)propyl]histidine. Diphthamide can be ADP-ribosylated bydiphtheria toxin and by Pseudomonas exotoxin A, thus arresting protein synthesis1
ISGylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P13639
EEF2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001952.1
ENSEMBL proteins: ENSP00000307940 Reactome Protein details: P13639
Human Recombinant Protein Products for EEF2:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
EEF2 for ontologies About GeneDecksing
EEF2 Antibody Products:
Assay Products for EEF2: |
Protein
Domains /
Families
for EEF2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
EEF2 for domains About GeneDecksing
5/9 InterPro domains/families (see all 9):Graphical View of Domain Structure for InterPro Entry P13639ProtoNet protein and cluster: P13639 2 Blocks protein families: IPB000640 Elongation factor G IPB005517 Elongation factor G
UniProtKB/Swiss-Prot: EF2_HUMAN, P13639Similarity: Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily |
Function
for EEF2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: EF2_HUMAN, P13639Function: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, theribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formedA-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes thecoordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome Genatlas biochemistry entry for EEF2:eukaryotic translation elongation factor 2
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
EEF2 for ontologies About GeneDecksing
Phenotypes:
5 GenomeRNAi human phenotypes for EEF2:
4 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Eef2):
EEF2 for phenotypes About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EEF2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EEF2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: EEF2 (NM_001961) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EEF2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EEF2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EEF2 |
|
Pathways & Interactions
for EEF2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Development_CNTF receptor signaling | | | 2 | Synthesis of PB1-F2 | | | 3 | Translation_Translation regulation by Alpha-1 adrenergic receptors | | | 4 | p70S6K Signaling | | | 5 | AMPK signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 EMD Millipore Pathways for EEF2
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for EEF2
1 
Cell Signaling Technology (CST) Pathway for EEF2
3  GeneGo (Thomson Reuters) Pathways for EEF2
3  BioSystems Pathways for EEF2
5 
Reactome Pathways for EEF2
EEF2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for EEF2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/490 Interacting proteins for EEF2 (P136392, 3 ENSP000003079404) via UniProtKB, MINT, STRING, and/or I2D (see all 490)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
EEF2 for ontologies About GeneDecksing
|
Drugs & Compounds
for EEF2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
EEF2 for compounds About GeneDecksing
 Browse Tocris compounds for EEF2
4 HMDB Compounds for EEF2 About this table
4 DrugBank Compounds for EEF2 About this table
10/47 Novoseek chemical compound relationships for EEF2 gene (see all 47) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| diphthamide |
88.3 |
16 |
1353910 (3), 15485916 (2), 1730643 (2), 14756556 (1) (see all 6) |
| apup |
88.3 |
1 |
7833807 (1) |
| sordarin |
78 |
14 |
11158355 (6), 15273103 (1) |
| exotoxin-a |
77.8 |
13 |
1353910 (1), 10861457 (1), 19527753 (1), 8692916 (1) (see all 7) |
| rapamycin |
69.7 |
32 |
11500364 (3), 15341530 (3), 7972087 (3), 12920134 (2) (see all 15) |
| ricin |
66.1 |
6 |
1425176 (1), 7999776 (1), 8318952 (1), 8253723 (1) |
| denileukin diftitox |
64.7 |
1 |
18684057 (1) |
| rottlerin |
58.1 |
5 |
8307162 (1), 18712774 (1), 17164244 (1) |
| adpribose |
53.8 |
10 |
17665640 (2), 15381153 (2), 16142694 (2), 8692916 (1) (see all 6) |
| nad+ |
52.1 |
6 |
8692916 (1), 8172890 (1), 14756556 (1), 16817779 (1) (see all 5) |
Search CenterWatch for drugs/clinical trials and news about EEF2 / EF2
|
Transcripts
for EEF2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for EEF2 gene: NM_001961.3 Unigene Cluster for EEF2: Eukaryotic translation elongation factor 2 Hs.515070 [show with all ESTs]Unigene Representative Sequence: NM_0019611 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000309311(uc002lze.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EEF2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EEF2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: EEF2 (NM_001961) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EEF2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EEF2 |
Additional cDNA sequence: AK297398.1 AK298498.1 AK299225.1 AY942181.1 BC006547.2 BC024689.1 BC126259.1 BC136313.1 M19997.1 X51466.1 Z11692.1 24/69 DOTS entries (see all 69): DT.95256406 DT.92466824 DT.92466830 DT.95256420 DT.452835 DT.91978289 DT.100041772 DT.100867128 DT.92047640 DT.92371227 DT.87016867 DT.100855407 DT.100658617 DT.75134632 DT.121430847 DT.92466819 DT.92466812 DT.121430864 DT.121430955 DT.92466810 DT.97864766 DT.91881089 DT.91986754 DT.92334137 24/1223 AceView cDNA sequences (see all 1223): AA318036 BF346066 BP871197 BG752927 AI458575 BE763786 NM_001961 BP340065 AW750967 F16254 BM563995 BQ058736 AI816561 BC024689 BG752445 AI816599 CR608809 BP355913 BM795808 BG259630 BM841061 BP353058 BF038841 BM853176
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for EEF2 (see all 9) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | · | 13c | · | 13d | ^ | 14 | ^ | 15 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | - | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 16a | · | 16b | ^ | 17a | · | 17b | · | 17c | ^ | 18 |
|---|
|
| SP1: | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | |
ECgene alternative splicing isoforms for EEF2
|
Expression
for EEF2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| EEF2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCACCTCCA
About this image
See EEF2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for EEF2
SOURCE GeneReport for Unigene cluster: Hs.515070
SABiosciences Custom PCR Arrays for EEF2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EEF2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EEF2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EEF2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EEF2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EEF2 |
Orthologs
for EEF2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for EEF2 gene from 10/45 species (see all 45) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
EEF21 |
eukaryotic translation elongation factor 2 |
85.63(n)
97.32(a) |
|
396325 NM_205368.1 NP_990699.1 |
lizard
(Anolis carolinensis) |
Reptilia |
EEF26GUF16 |
-- |
94(a)28(a) |
1 ↔ 1possible ortholog |
1(34419410-34436691) 5(102261511-102279396) |
African clawed frog
(Xenopus laevis) |
Amphibia |
eef2-prov2 |
eukaryotic translation elongation factor 2 |
79(n) |
|
BC044327.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc635842 |
hypothetical protein MGC63584 |
82.65(n) |
|
393430 BC063965.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Ef2b3 |
protein biosynthesis translation elongation
factor |
78(a) |
|
39E7 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
eft-23 |
Elongation factor Tu family (contains
ATP/GTP more |
78(a)
(best of 2) |
|
I(9171713-9174757) -- |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
EFT1(YOR133W)4
EFT21 |
Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes more4
Eft2p1 |
61.32(n)1
67.46(a)1 |
|
15(575098-577626)4
8519931 NP_010673.11 8543014
NP_014776.14 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT3G129151 |
Ribosomal protein S5/Elongation factor G/III/V family more |
36.59(n)
22.13(a) |
|
3768815 NM_001161139.2 NP_001154611.1 |
rice
(Oryza sativa) |
Liliopsida |
AK073592.12 |
-- |
76.85(n) |
|
AK073592.1 |
E. coli
(Escherichia coli) |
Gamma proteobacteria |
typA6 |
GTP-binding protein |
21(a) |
possible ortholog |
Chromosome(4056430-4058253) |
ENSEMBL Gene Tree for EEF2 (if available)
TreeFam Gene Tree for EEF2 (if available) |
Paralogs
for EEF2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for EEF2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for EEF2 (3976054 - 3985461 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for EEF2
2 CNVs: 35626 35625 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EEF2 |
|
Disorders
/ Diseases
for EEF2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
EEF2 for disorders About GeneDecksing
OMIM gene information: 130610
OMIM disorders: --
20/26  diseases for EEF2 (see all 26): About MalaCardstreacher collins syndrome visceral leishmaniasis oral squamous cell carcinoma squamous cell carcinoma
diphtheria leishmaniasis alzheimer's disease adenocarcinoma
breast cancer lung adenocarcinoma prostate adenocarcinoma hepatocellular carcinoma
ovarian carcinoma carcinoma prostatitis prostate cancer
ischemia glioblastoma hypoxia retinitis
1 disease from the University of Copenhagen DISEASES database for EEF2:Diphtheria 9 Novoseek disease relationships for EEF2 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| diphtheria |
83.4 |
39 |
14756556 (3), 16142694 (2), 2109323 (1), 1939154 (1) (see all 27) |
| intoxication |
35 |
4 |
2140788 (1), 9430652 (1), 9398176 (1) |
| shock |
14.5 |
13 |
8361337 (1), 12641431 (1), 18762224 (1), 15749383 (1) (see all 9) |
| cancer |
1.96 |
5 |
18161940 (1), 11254220 (1), 20300520 (1), 19244119 (1) |
| glioma |
0 |
1 |
11358819 (1) |
| breast cancer |
0 |
6 |
20300520 (2), 16648488 (1), 15289310 (1) |
| tumors |
0 |
1 |
15660415 (1) |
| alzheimers disease |
0 |
3 |
1331687 (2), 16098202 (1) |
| carcinoma |
0 |
2 |
15534876 (1) |
Human Genome Epidemiology (HuGE) Navigator: EEF2 (1 document)
Export disorders for EEF2 gene to outside databases
|
Publications
for EEF2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for EEF2 gene, integrated from 9 sources (see all 300):
(articles sorted by number of sources associating them with EEF2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequence of the coding region of human elongation factor 2 (EF-2) by enzymatic amplification of cDNA from human ovarian granulosa cells. (PubMed id 2610926)1, 2, 3 Rapp G.... Heinz K. (1989)
- SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay. (PubMed id 19417104)1, 2 Yamashita A....Ohno S. (2009)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Construction of a plasmid containing the complete coding region of human elongation factor 2. (PubMed id 1596361)1, 2 Hanes J.... Scheit K.H. (1992)
- Cloning and sequence analysis of a cDNA from human ovarian granulosa cells encoding the C-terminal part of human elongation factor 2. (PubMed id 2840927)1, 2 Rapp G.... Scheit K.H. (1988)
- Chromosomal assignment of the gene for human elongation factor 2. (PubMed id 6427766)1, 3 Kaneda Y....Okada Y. (1984)
- Regulation of elongation factor-2 by multisite phosphorylation. (PubMed id 8386634)1, 9 Redpath N.T....Proud C.G. (1993)
- High hydrostatic pressure inhibits the biosynthesis of eukaryotic elongation factor-2. (PubMed id 15534876)1, 9 Elo M.A....Lammi M.J. (2005)
- Cytoplasmic complex of p53 and eEF2. (PubMed id 12891704)1, 9 Yin X....Carroll R.B. (2003)
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External Searches for EEF2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing EEF2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing EEF2 gene
(According to HUGE)
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Specialized Databases showing EEF2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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About This Section
| Patent Information for EEF2 gene:
Search GeneIP for patents involving EEF2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for EEF2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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| | |  | OriGene Antibodies for EEF2 | | OriGene shRNA RFP for EEF2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EEF2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EEF2 | | | OriGene Protein Over-expression Lysate for EEF2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for EEF2 | | OriGene 3'-UTR Clone for EEF2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EEF2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EEF2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for EEF2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for EEF2 | | OriGene Custom Protein Services for EEF2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat EEF2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EEF2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EEF2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EEF2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EEF2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EEF2 |
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| | Antibodies & Assays for EEF2 (eEF-2) |
| | | | Search Tocris compounds for EEF2 |
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 | | | EEF2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EEF2 |
|  |  |  |  | | | | ThermoFisher Antibody for EEF2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EEF2 |
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