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Aliases for EEF1G Gene

Aliases for EEF1G Gene

  • Eukaryotic Translation Elongation Factor 1 Gamma 2 3
  • EEF-1B Gamma 3 4
  • EF-1-Gamma 3 4
  • EF1G 3 4
  • Translation Elongation Factor EEF-1 Gamma Chain 3
  • Pancreatic Tumor-Related Protein 3
  • PRO1608 3
  • GIG35 3

External Ids for EEF1G Gene

Previous GeneCards Identifiers for EEF1G Gene

  • GC11M064840
  • GC11M063902
  • GC11M062577
  • GC11M062102
  • GC11M062083
  • GC11M062328
  • GC11M062332

Summaries for EEF1G Gene

Entrez Gene Summary for EEF1G Gene

  • This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit contains an N-terminal glutathione transferase domain, which may be involved in regulating the assembly of multisubunit complexes containing this elongation factor and aminoacyl-tRNA synthetases. [provided by RefSeq, Jul 2008]

GeneCards Summary for EEF1G Gene

EEF1G (Eukaryotic Translation Elongation Factor 1 Gamma) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Gene Expression. GO annotations related to this gene include translation elongation factor activity.

UniProtKB/Swiss-Prot for EEF1G Gene

  • Probably plays a role in anchoring the complex to other cellular components

Gene Wiki entry for EEF1G Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EEF1G Gene

Genomics for EEF1G Gene

Regulatory Elements for EEF1G Gene

Genomic Location for EEF1G Gene

Chromosome:
11
Start:
62,559,601 bp from pter
End:
62,574,086 bp from pter
Size:
14,486 bases
Orientation:
Minus strand

Genomic View for EEF1G Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EEF1G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EEF1G Gene

Proteins for EEF1G Gene

  • Protein details for EEF1G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P26641-EF1G_HUMAN
    Recommended name:
    Elongation factor 1-gamma
    Protein Accession:
    P26641
    Secondary Accessions:
    • B4DTG2
    • Q6PJ62
    • Q6PK31
    • Q96CU2
    • Q9P196

    Protein attributes for EEF1G Gene

    Size:
    437 amino acids
    Molecular mass:
    50119 Da
    Quaternary structure:
    • EF-1 is composed of four subunits: alpha, beta, delta, and gamma

    Three dimensional structures from OCA and Proteopedia for EEF1G Gene

    Alternative splice isoforms for EEF1G Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EEF1G Gene

Proteomics data for EEF1G Gene at MOPED

Post-translational modifications for EEF1G Gene

  • Ubiquitination at Lys 17 and Lys 294
  • Modification sites at PhosphoSitePlus

Other Protein References for EEF1G Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for EEF1G Gene

Domains & Families for EEF1G Gene

Suggested Antigen Peptide Sequences for EEF1G Gene

Graphical View of Domain Structure for InterPro Entry

P26641

UniProtKB/Swiss-Prot:

EF1G_HUMAN :
  • Contains 1 EF-1-gamma C-terminal domain.
Domain:
  • Contains 1 EF-1-gamma C-terminal domain.
  • Contains 1 GST C-terminal domain.
  • Contains 1 GST N-terminal domain.
genes like me logo Genes that share domains with EEF1G: view

No data available for Gene Families for EEF1G Gene

Function for EEF1G Gene

Molecular function for EEF1G Gene

UniProtKB/Swiss-Prot Function:
Probably plays a role in anchoring the complex to other cellular components
UniProtKB/Swiss-Prot Induction:
Down-regulated in response to enterovirus 71 (EV71) infection.

Gene Ontology (GO) - Molecular Function for EEF1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003746 translation elongation factor activity IBA --
GO:0004364 glutathione transferase activity IBA --
GO:0005515 protein binding IPI 10908348
genes like me logo Genes that share ontologies with EEF1G: view

Phenotypes for EEF1G Gene

GenomeRNAi human phenotypes for EEF1G:
genes like me logo Genes that share phenotypes with EEF1G: view

Animal Model Products

miRNA for EEF1G Gene

miRTarBase miRNAs that target EEF1G

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EEF1G

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for EEF1G Gene

Localization for EEF1G Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EEF1G Gene COMPARTMENTS Subcellular localization image for EEF1G gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for EEF1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm IDA 8743958
GO:0005783 colocalizes_with endoplasmic reticulum IDA 8743958
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with EEF1G: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for EEF1G Gene

Pathways & Interactions for EEF1G Gene

genes like me logo Genes that share pathways with EEF1G: view

Pathways by source for EEF1G Gene

1 BioSystems pathway for EEF1G Gene
1 KEGG pathway for EEF1G Gene

Gene Ontology (GO) - Biological Process for EEF1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation TAS --
GO:0006414 translational elongation TAS --
GO:0006749 glutathione metabolic process IBA --
GO:0009615 response to virus IEP 16548883
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with EEF1G: view

No data available for SIGNOR curated interactions for EEF1G Gene

Drugs & Compounds for EEF1G Gene

(1) Additional Compounds for EEF1G Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Aminoacyl-tRNA
genes like me logo Genes that share compounds with EEF1G: view

Transcripts for EEF1G Gene

mRNA/cDNA for EEF1G Gene

Unigene Clusters for EEF1G Gene

Eukaryotic translation elongation factor 1 gamma:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EEF1G

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EEF1G Gene

No ASD Table

Relevant External Links for EEF1G Gene

GeneLoc Exon Structure for
EEF1G
ECgene alternative splicing isoforms for
EEF1G

Expression for EEF1G Gene

mRNA expression in normal human tissues for EEF1G Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EEF1G Gene



SOURCE GeneReport for Unigene cluster for EEF1G Gene Hs.144835

mRNA Expression by UniProt/SwissProt for EEF1G Gene

P26641-EF1G_HUMAN
Tissue specificity: Highly expressed in pancreatic tumor tissue and to a lesser extent in normal kidney, intestine, pancreas, stomach, lung, brain, spleen and liver
genes like me logo Genes that share expression patterns with EEF1G: view

Protein tissue co-expression partners for EEF1G Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for EEF1G Gene

Orthologs for EEF1G Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EEF1G Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EEF1G 35
  • 92.75 (n)
  • 97.94 (a)
EEF1G 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EEF1G 35
  • 94.81 (n)
  • 98.4 (a)
-- 36
  • 98 (a)
OneToMany
-- 36
  • 92 (a)
OneToMany
-- 36
  • 96 (a)
OneToMany
-- 36
  • 70 (a)
OneToMany
-- 36
  • 94 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Eef1g 35
  • 91.46 (n)
  • 98.17 (a)
Eef1g 16
Eef1g 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EEF1G 35
  • 99.77 (n)
  • 100 (a)
EEF1G 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eef1g 35
  • 89.7 (n)
  • 97.71 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 92 (a)
OneToMany
-- 36
  • 68 (a)
OneToMany
-- 36
  • 55 (a)
OneToMany
-- 36
  • 92 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia EEF1G 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 84 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76278 35
African clawed frog
(Xenopus laevis)
Amphibia LOC397861 35
zebrafish
(Danio rerio)
Actinopterygii eef1g 35
  • 75.54 (n)
  • 77.98 (a)
eef1g 36
  • 77 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12147 35
fruit fly
(Drosophila melanogaster)
Insecta Ef1gamma 37
  • 57 (a)
Ef1gamma 35
  • 63.16 (n)
  • 59.58 (a)
Ef1gamma 36
  • 58 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000883 35
  • 60.47 (n)
  • 58.35 (a)
worm
(Caenorhabditis elegans)
Secernentea eef-1G 35
  • 55.89 (n)
  • 52.16 (a)
eef-1G 36
  • 49 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR147C 35
  • 49.17 (n)
  • 37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CAM1 36
  • 34 (a)
OneToMany
TEF4 36
  • 34 (a)
OneToMany
CAM1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G09640 35
  • 49.88 (n)
  • 41.03 (a)
rice
(Oryza sativa)
Liliopsida Os02g0220600 35
  • 48.18 (n)
  • 39.42 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2821 36
  • 50 (a)
OneToOne
Species with no ortholog for EEF1G:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EEF1G Gene

ENSEMBL:
Gene Tree for EEF1G (if available)
TreeFam:
Gene Tree for EEF1G (if available)

Paralogs for EEF1G Gene

(1) SIMAP similar genes for EEF1G Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with EEF1G: view

No data available for Paralogs for EEF1G Gene

Variants for EEF1G Gene

Sequence variations from dbSNP and Humsavar for EEF1G Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs556951 -- 62,565,028(+) agatc(A/G)cacca intron-variant
rs556954 -- 62,565,030(+) atcac(A/G)ccact intron-variant
rs739793 -- 62,574,211(-) GGCCA(A/G)CAACC upstream-variant-2KB
rs1283238 -- 62,559,177(+) gaaaa(A/G)aaaag downstream-variant-500B
rs1292961 -- 62,564,806(+) ctcac(A/G)cctgt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EEF1G Gene

Variant ID Type Subtype PubMed ID
nsv832180 CNV Loss 17160897
nsv832182 CNV Gain+Loss 17160897
nsv347 CNV Loss 18451855
nsv825939 CNV Gain 20364138

Variation tolerance for EEF1G Gene

Residual Variation Intolerance Score: 26.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.46; 10.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EEF1G Gene

HapMap Linkage Disequilibrium report
EEF1G

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EEF1G Gene

Disorders for EEF1G Gene

Relevant External Links for EEF1G

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EEF1G
genes like me logo Genes that share disorders with EEF1G: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EEF1G Gene

Publications for EEF1G Gene

  1. Elongation factor-1 messenger-RNA levels in cultured cells are high compared to tissue and are not drastically affected further by oncogenic transformation. (PMID: 1461723) Sanders J. … Moeller W. (Nucleic Acids Res. 1992) 2 23 67
  2. Human cDNAs encoding elongation factor 1 gamma and the ribosomal protein L19. (PMID: 1598220) Kumabe T. … Yamamoto T. (Nucleic Acids Res. 1992) 2 23 67
  3. The effect of oxytocin and an oxytocin antagonist on the human myometrial proteome. (PMID: 19767541) de Wit N.C. … Thornton S. (Reprod Sci 2010) 23 67
  4. Utility of the nuclear protein-coding gene, elongation factor-1 gamma (EF-1gamma), for spider systematics, emphasizing family level relationships of tarantulas and their kin (Araneae: Mygalomorphae). (PMID: 16971146) Ayoub N.A. … Hayashi C.Y. (Mol. Phylogenet. Evol. 2007) 23 67
  5. Leishmania chagasi T-cell antigens identified through a double library screen. (PMID: 17000724) Martins D.R. … Wilson M.E. (Infect. Immun. 2006) 23 67

Products for EEF1G Gene

Sources for EEF1G Gene

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