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Aliases for EEF1G Gene

Aliases for EEF1G Gene

  • Eukaryotic Translation Elongation Factor 1 Gamma 2 3 5
  • EEF-1B Gamma 3 4
  • EF-1-Gamma 3 4
  • EF1G 3 4
  • Translation Elongation Factor EEF-1 Gamma Chain 3
  • Pancreatic Tumor-Related Protein 3
  • Elongation Factor 1-Gamma 3
  • PRO1608 3
  • GIG35 3

External Ids for EEF1G Gene

Previous GeneCards Identifiers for EEF1G Gene

  • GC11M064840
  • GC11M063902
  • GC11M062577
  • GC11M062102
  • GC11M062083
  • GC11M062328
  • GC11M062332

Summaries for EEF1G Gene

Entrez Gene Summary for EEF1G Gene

  • This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit contains an N-terminal glutathione transferase domain, which may be involved in regulating the assembly of multisubunit complexes containing this elongation factor and aminoacyl-tRNA synthetases. [provided by RefSeq, Jul 2008]

GeneCards Summary for EEF1G Gene

EEF1G (Eukaryotic Translation Elongation Factor 1 Gamma) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Legionellosis. GO annotations related to this gene include translation elongation factor activity.

UniProtKB/Swiss-Prot for EEF1G Gene

  • Probably plays a role in anchoring the complex to other cellular components.

Gene Wiki entry for EEF1G Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EEF1G Gene

Genomics for EEF1G Gene

Regulatory Elements for EEF1G Gene

Enhancers for EEF1G Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F062496 1 FANTOM5 Ensembl ENCODE 30.5 +70.9 70882 13.5 PKNOX1 MLX ARID4B SIN3A DMAP1 YBX1 ZNF143 FOS DEK SP5 EEF1G NXF1 INTS5 METTL12 STX5 MTA2 AHNAK SNHG1 LOC105369332 ENSG00000250659
GH11F062041 1.4 Ensembl ENCODE 26.9 +528.7 528659 8.1 MLX CREB3L1 ZFP64 DMAP1 FEZF1 YY1 ZNF143 SP3 NFYC MEF2D METTL12 INTS5 SNHG1 NXF1 TMEM138 LOC105369332 VPS37C EML3 MTA2 TAF6L
GH11F062597 0.7 VISTA ENCODE 20.6 -26.5 -26535 6.2 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A YBX1 DMAP1 ZNF2 SLC30A9 EML3 EEF1G TTC9C INTS5 LOC105369332 MIR6748 NXF1 HNRNPUL2 UBXN1 MTA2
GH11F062838 0.2 ENCODE 20.4 -266.8 -266760 4.8 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 METTL12 UBXN1 LRRN4CL NXF1 TAF6L INTS5 IMMP1LP1 SNHG1 TTC9C STX5
GH11F062852 1.3 FANTOM5 ENCODE 19 -281.8 -281752 5.9 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC METTL12 INTS5 NXF1 SNHG1 UBXN1 MTA2 EML3 MIR6748 LOC105369332 STX5
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around EEF1G on UCSC Golden Path with GeneCards custom track

Promoters for EEF1G Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001570669 86 2401 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Location for EEF1G Gene

Chromosome:
11
Start:
62,559,601 bp from pter
End:
62,574,086 bp from pter
Size:
14,486 bases
Orientation:
Minus strand

Genomic View for EEF1G Gene

Genes around EEF1G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EEF1G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EEF1G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EEF1G Gene

Proteins for EEF1G Gene

  • Protein details for EEF1G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P26641-EF1G_HUMAN
    Recommended name:
    Elongation factor 1-gamma
    Protein Accession:
    P26641
    Secondary Accessions:
    • B4DTG2
    • Q6PJ62
    • Q6PK31
    • Q96CU2
    • Q9P196

    Protein attributes for EEF1G Gene

    Size:
    437 amino acids
    Molecular mass:
    50119 Da
    Quaternary structure:
    • EF-1 is composed of four subunits: alpha, beta, delta, and gamma.

    Three dimensional structures from OCA and Proteopedia for EEF1G Gene

    Alternative splice isoforms for EEF1G Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EEF1G Gene

Post-translational modifications for EEF1G Gene

  • Ubiquitination at Lys 17 and Lys 294
  • Modification sites at PhosphoSitePlus

Other Protein References for EEF1G Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EEF1G Gene

Domains & Families for EEF1G Gene

Suggested Antigen Peptide Sequences for EEF1G Gene

Graphical View of Domain Structure for InterPro Entry

P26641

UniProtKB/Swiss-Prot:

EF1G_HUMAN :
  • Contains 1 EF-1-gamma C-terminal domain.
Domain:
  • Contains 1 EF-1-gamma C-terminal domain.
  • Contains 1 GST C-terminal domain.
  • Contains 1 GST N-terminal domain.
genes like me logo Genes that share domains with EEF1G: view

No data available for Gene Families for EEF1G Gene

Function for EEF1G Gene

Molecular function for EEF1G Gene

UniProtKB/Swiss-Prot Function:
Probably plays a role in anchoring the complex to other cellular components.
UniProtKB/Swiss-Prot Induction:
Down-regulated in response to enterovirus 71 (EV71) infection.

Gene Ontology (GO) - Molecular Function for EEF1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003727 single-stranded RNA binding TAS --
GO:0003729 mRNA binding IDA --
GO:0003730 mRNA 3-UTR binding IBA --
GO:0003746 translation elongation factor activity IBA --
genes like me logo Genes that share ontologies with EEF1G: view

Phenotypes for EEF1G Gene

genes like me logo Genes that share phenotypes with EEF1G: view

Animal Model Products

miRNA for EEF1G Gene

miRTarBase miRNAs that target EEF1G

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EEF1G Gene

Localization for EEF1G Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EEF1G Gene COMPARTMENTS Subcellular localization image for EEF1G gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 4
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for EEF1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000178 exosome (RNase complex) IDA --
GO:0000932 cytoplasmic mRNA processing body IDA --
GO:0005634 nucleus IEA,IDA 21630459
GO:0005737 cytoplasm IDA,TAS 8743958
GO:0005783 colocalizes_with endoplasmic reticulum IDA 8743958
genes like me logo Genes that share ontologies with EEF1G: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for EEF1G Gene

Pathways & Interactions for EEF1G Gene

genes like me logo Genes that share pathways with EEF1G: view

Pathways by source for EEF1G Gene

1 BioSystems pathway for EEF1G Gene
1 KEGG pathway for EEF1G Gene

Gene Ontology (GO) - Biological Process for EEF1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade ISS --
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IDA --
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening IMP --
GO:0006402 mRNA catabolic process TAS --
GO:0006412 translation IEA --
genes like me logo Genes that share ontologies with EEF1G: view

No data available for SIGNOR curated interactions for EEF1G Gene

Drugs & Compounds for EEF1G Gene

(1) Additional Compounds for EEF1G Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with EEF1G: view

Transcripts for EEF1G Gene

Unigene Clusters for EEF1G Gene

Eukaryotic translation elongation factor 1 gamma:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EEF1G Gene

No ASD Table

Relevant External Links for EEF1G Gene

GeneLoc Exon Structure for
EEF1G
ECgene alternative splicing isoforms for
EEF1G

Expression for EEF1G Gene

mRNA expression in normal human tissues for EEF1G Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EEF1G Gene



Protein tissue co-expression partners for EEF1G Gene

NURSA nuclear receptor signaling pathways regulating expression of EEF1G Gene:

EEF1G

SOURCE GeneReport for Unigene cluster for EEF1G Gene:

Hs.144835

mRNA Expression by UniProt/SwissProt for EEF1G Gene:

P26641-EF1G_HUMAN
Tissue specificity: Highly expressed in pancreatic tumor tissue and to a lesser extent in normal kidney, intestine, pancreas, stomach, lung, brain, spleen and liver.
genes like me logo Genes that share expression patterns with EEF1G: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for EEF1G Gene

Orthologs for EEF1G Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EEF1G Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EEF1G 34 35
  • 99.77 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 98 (a)
OneToMany
-- 35
  • 96 (a)
OneToMany
EEF1G 34
  • 94.81 (n)
-- 35
  • 94 (a)
OneToMany
-- 35
  • 92 (a)
OneToMany
-- 35
  • 70 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia EEF1G 35
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EEF1G 34 35
  • 92.75 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 92 (a)
OneToMany
-- 35
  • 92 (a)
OneToMany
-- 35
  • 68 (a)
OneToMany
-- 35
  • 55 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Eef1g 34 16 35
  • 91.46 (n)
rat
(Rattus norvegicus)
Mammalia Eef1g 34
  • 89.7 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 86 (a)
OneToMany
-- 35
  • 84 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76278 34
African clawed frog
(Xenopus laevis)
Amphibia LOC397861 34
zebrafish
(Danio rerio)
Actinopterygii eef1g 34 35
  • 75.54 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12147 34
fruit fly
(Drosophila melanogaster)
Insecta Ef1gamma 36 34 35
  • 63.16 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000883 34
  • 60.47 (n)
worm
(Caenorhabditis elegans)
Secernentea eef-1G 34 35
  • 55.89 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR147C 34
  • 49.17 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CAM1 35 37
  • 34 (a)
OneToMany
TEF4 35
  • 34 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G09640 34
  • 49.88 (n)
rice
(Oryza sativa)
Liliopsida Os02g0220600 34
  • 48.18 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2821 35
  • 50 (a)
OneToOne
Species where no ortholog for EEF1G was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EEF1G Gene

ENSEMBL:
Gene Tree for EEF1G (if available)
TreeFam:
Gene Tree for EEF1G (if available)

Paralogs for EEF1G Gene

(1) SIMAP similar genes for EEF1G Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with EEF1G: view

No data available for Paralogs for EEF1G Gene

Variants for EEF1G Gene

Sequence variations from dbSNP and Humsavar for EEF1G Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10444357 -- 62,561,239(+) cgttt(C/T)tacta intron-variant
rs1056044 -- 62,574,921(+) AAGGA(A/G)AAGCT downstream-variant-500B, upstream-variant-2KB
rs1061093 -- 62,567,436(-) TTGGG(C/G)GAAGT upstream-variant-2KB, reference, synonymous-codon
rs10750975 -- 62,564,790(+) GGGCC(A/G)GGCAC intron-variant
rs111252669 -- 62,570,720(+) TGGCT(A/T)ATTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EEF1G Gene

Variant ID Type Subtype PubMed ID
esv3584599 CNV gain 24956385
nsv347 CNV deletion 18451855
nsv555174 CNV gain 21841781
nsv825939 CNV gain 20364138
nsv832180 CNV loss 17160897
nsv832182 CNV gain+loss 17160897
nsv975193 CNV duplication 23825009

Variation tolerance for EEF1G Gene

Residual Variation Intolerance Score: 26.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.46; 10.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EEF1G Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EEF1G

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EEF1G Gene

Disorders for EEF1G Gene

Relevant External Links for EEF1G

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EEF1G

No disorders were found for EEF1G Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EEF1G Gene

Publications for EEF1G Gene

  1. Elongation factor-1 messenger-RNA levels in cultured cells are high compared to tissue and are not drastically affected further by oncogenic transformation. (PMID: 1461723) Sanders J. … Moeller W. (Nucleic Acids Res. 1992) 2 3 4 22 64
  2. Human cDNAs encoding elongation factor 1 gamma and the ribosomal protein L19. (PMID: 1598220) Kumabe T. … Yamamoto T. (Nucleic Acids Res. 1992) 2 3 4 22 64
  3. Expression of elongation factor-1 gamma-related sequence in human pancreatic cancer. (PMID: 1372736) Lew Y. … Frazier M.L. (Pancreas 1992) 3 4 22 64
  4. Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection. (PMID: 16548883) Leong W.F. … Chow V.T. (Cell. Microbiol. 2006) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for EEF1G Gene

Sources for EEF1G Gene

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