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Aliases for EEF1G Gene

Aliases for EEF1G Gene

  • Eukaryotic Translation Elongation Factor 1 Gamma 2 3 5
  • EEF-1B Gamma 3 4
  • EF-1-Gamma 3 4
  • EF1G 3 4
  • Translation Elongation Factor EEF-1 Gamma Chain 3
  • Pancreatic Tumor-Related Protein 3
  • PRO1608 3
  • GIG35 3

External Ids for EEF1G Gene

Previous GeneCards Identifiers for EEF1G Gene

  • GC11M064840
  • GC11M063902
  • GC11M062577
  • GC11M062102
  • GC11M062083
  • GC11M062328
  • GC11M062332

Summaries for EEF1G Gene

Entrez Gene Summary for EEF1G Gene

  • This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit contains an N-terminal glutathione transferase domain, which may be involved in regulating the assembly of multisubunit complexes containing this elongation factor and aminoacyl-tRNA synthetases. [provided by RefSeq, Jul 2008]

GeneCards Summary for EEF1G Gene

EEF1G (Eukaryotic Translation Elongation Factor 1 Gamma) is a Protein Coding gene. Among its related pathways are Gene Expression and Viral mRNA Translation. GO annotations related to this gene include translation elongation factor activity.

UniProtKB/Swiss-Prot for EEF1G Gene

  • Probably plays a role in anchoring the complex to other cellular components.

Gene Wiki entry for EEF1G Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EEF1G Gene

Genomics for EEF1G Gene

Regulatory Elements for EEF1G Gene

Enhancers for EEF1G Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around EEF1G on UCSC Golden Path with GeneCards custom track

Promoters for EEF1G Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EEF1G on UCSC Golden Path with GeneCards custom track

Genomic Location for EEF1G Gene

62,559,601 bp from pter
62,574,086 bp from pter
14,486 bases
Minus strand

Genomic View for EEF1G Gene

Genes around EEF1G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EEF1G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EEF1G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EEF1G Gene

Proteins for EEF1G Gene

  • Protein details for EEF1G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Elongation factor 1-gamma
    Protein Accession:
    Secondary Accessions:
    • B4DTG2
    • Q6PJ62
    • Q6PK31
    • Q96CU2
    • Q9P196

    Protein attributes for EEF1G Gene

    437 amino acids
    Molecular mass:
    50119 Da
    Quaternary structure:
    • EF-1 is composed of four subunits: alpha, beta, delta, and gamma.

    Three dimensional structures from OCA and Proteopedia for EEF1G Gene

    Alternative splice isoforms for EEF1G Gene


neXtProt entry for EEF1G Gene

Proteomics data for EEF1G Gene at MOPED

Post-translational modifications for EEF1G Gene

  • Ubiquitination at Lys 17 and Lys 294
  • Modification sites at PhosphoSitePlus

Other Protein References for EEF1G Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EEF1G Gene

Domains & Families for EEF1G Gene

Suggested Antigen Peptide Sequences for EEF1G Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 EF-1-gamma C-terminal domain.
  • Contains 1 EF-1-gamma C-terminal domain.
  • Contains 1 GST C-terminal domain.
  • Contains 1 GST N-terminal domain.
genes like me logo Genes that share domains with EEF1G: view

No data available for Gene Families for EEF1G Gene

Function for EEF1G Gene

Molecular function for EEF1G Gene

UniProtKB/Swiss-Prot Function:
Probably plays a role in anchoring the complex to other cellular components.
UniProtKB/Swiss-Prot Induction:
Down-regulated in response to enterovirus 71 (EV71) infection.

Gene Ontology (GO) - Molecular Function for EEF1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 10908348
genes like me logo Genes that share ontologies with EEF1G: view

Phenotypes for EEF1G Gene

GenomeRNAi human phenotypes for EEF1G:
genes like me logo Genes that share phenotypes with EEF1G: view

Animal Model Products

miRNA for EEF1G Gene

miRTarBase miRNAs that target EEF1G

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EEF1G Gene

Localization for EEF1G Gene

Subcellular locations from

Jensen Localization Image for EEF1G Gene COMPARTMENTS Subcellular localization image for EEF1G gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 4
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for EEF1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 8743958
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with EEF1G: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for EEF1G Gene

Pathways & Interactions for EEF1G Gene

genes like me logo Genes that share pathways with EEF1G: view

Pathways by source for EEF1G Gene

1 BioSystems pathway for EEF1G Gene
1 KEGG pathway for EEF1G Gene

Gene Ontology (GO) - Biological Process for EEF1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation TAS --
GO:0006749 glutathione metabolic process IBA --
genes like me logo Genes that share ontologies with EEF1G: view

No data available for SIGNOR curated interactions for EEF1G Gene

Drugs & Compounds for EEF1G Gene

(1) Additional Compounds for EEF1G Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with EEF1G: view

Transcripts for EEF1G Gene

Unigene Clusters for EEF1G Gene

Eukaryotic translation elongation factor 1 gamma:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EEF1G Gene

No ASD Table

Relevant External Links for EEF1G Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EEF1G Gene

mRNA expression in normal human tissues for EEF1G Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EEF1G Gene

SOURCE GeneReport for Unigene cluster for EEF1G Gene Hs.144835

mRNA Expression by UniProt/SwissProt for EEF1G Gene

Tissue specificity: Highly expressed in pancreatic tumor tissue and to a lesser extent in normal kidney, intestine, pancreas, stomach, lung, brain, spleen and liver.
genes like me logo Genes that share expression patterns with EEF1G: view

Protein tissue co-expression partners for EEF1G Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for EEF1G Gene

Orthologs for EEF1G Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EEF1G Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia EEF1G 35
  • 92.75 (n)
  • 97.94 (a)
EEF1G 36
  • 97 (a)
(Canis familiaris)
Mammalia EEF1G 35
  • 94.81 (n)
  • 98.4 (a)
-- 36
  • 98 (a)
-- 36
  • 92 (a)
-- 36
  • 96 (a)
-- 36
  • 70 (a)
-- 36
  • 94 (a)
(Mus musculus)
Mammalia Eef1g 35
  • 91.46 (n)
  • 98.17 (a)
Eef1g 16
Eef1g 36
  • 98 (a)
(Pan troglodytes)
Mammalia EEF1G 35
  • 99.77 (n)
  • 100 (a)
EEF1G 36
  • 89 (a)
(Rattus norvegicus)
Mammalia Eef1g 35
  • 89.7 (n)
  • 97.71 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 92 (a)
-- 36
  • 68 (a)
-- 36
  • 55 (a)
-- 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia EEF1G 36
  • 93 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 84 (a)
-- 36
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76278 35
African clawed frog
(Xenopus laevis)
Amphibia LOC397861 35
(Danio rerio)
Actinopterygii eef1g 35
  • 75.54 (n)
  • 77.98 (a)
eef1g 36
  • 77 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12147 35
fruit fly
(Drosophila melanogaster)
Insecta Ef1gamma 37
  • 57 (a)
Ef1gamma 35
  • 63.16 (n)
  • 59.58 (a)
Ef1gamma 36
  • 58 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000883 35
  • 60.47 (n)
  • 58.35 (a)
(Caenorhabditis elegans)
Secernentea eef-1G 35
  • 55.89 (n)
  • 52.16 (a)
eef-1G 36
  • 49 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR147C 35
  • 49.17 (n)
  • 37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CAM1 36
  • 34 (a)
TEF4 36
  • 34 (a)
CAM1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G09640 35
  • 49.88 (n)
  • 41.03 (a)
(Oryza sativa)
Liliopsida Os02g0220600 35
  • 48.18 (n)
  • 39.42 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2821 36
  • 50 (a)
Species with no ortholog for EEF1G:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EEF1G Gene

Gene Tree for EEF1G (if available)
Gene Tree for EEF1G (if available)

Paralogs for EEF1G Gene

(1) SIMAP similar genes for EEF1G Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with EEF1G: view

No data available for Paralogs for EEF1G Gene

Variants for EEF1G Gene

Sequence variations from dbSNP and Humsavar for EEF1G Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs556951 -- 62,565,028(+) agatc(A/G)cacca intron-variant
rs556954 -- 62,565,030(+) atcac(A/G)ccact intron-variant
rs739793 -- 62,574,211(-) GGCCA(A/G)CAACC upstream-variant-2KB
rs1283238 -- 62,559,177(+) gaaaa(A/G)aaaag downstream-variant-500B
rs1292961 -- 62,564,806(+) ctcac(A/G)cctgt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EEF1G Gene

Variant ID Type Subtype PubMed ID
nsv832180 CNV Loss 17160897
nsv832182 CNV Gain+Loss 17160897
nsv347 CNV Loss 18451855
nsv825939 CNV Gain 20364138

Variation tolerance for EEF1G Gene

Residual Variation Intolerance Score: 26.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.46; 10.12% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for EEF1G Gene

Disorders for EEF1G Gene

Relevant External Links for EEF1G

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for EEF1G Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EEF1G Gene

Publications for EEF1G Gene

  1. Human cDNAs encoding elongation factor 1 gamma and the ribosomal protein L19. (PMID: 1598220) Kumabe T. … Yamamoto T. (Nucleic Acids Res. 1992) 2 3 4 23 67
  2. Elongation factor-1 messenger-RNA levels in cultured cells are high compared to tissue and are not drastically affected further by oncogenic transformation. (PMID: 1461723) Sanders J. … Moeller W. (Nucleic Acids Res. 1992) 2 3 23
  3. An elongation factor-associating domain is inserted into human cysteinyl-tRNA synthetase by alternative splicing. (PMID: 10908348) Kim J.E. … Kim S. (Nucleic Acids Res. 2000) 3 23
  4. Expression of elongation factor-1 gamma-related sequence in human pancreatic cancer. (PMID: 1372736) Lew Y. … Frazier M.L. (Pancreas 1992) 3 23
  5. Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. (PMID: 25192599) Wang T. … Xu J. (Neurobiol. Aging 2015) 3

Products for EEF1G Gene

Sources for EEF1G Gene