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EEF1E1 Gene

protein-coding   GIFtS: 52
GCID: GC06M008024

Eukaryotic Translation Elongation Factor 1 Epsilon 1


(Previous symbol: P18)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Eukaryotic Translation Elongation Factor 1 Epsilon 11 2     ARS-Interacting Multifunctional Protein 32
P181 2 3     Eukaryotic Translation Elongation Factor 1 Epsilon-12
Aminoacyl TRNA Synthetase Complex-Interacting Multifunctional Protein 31 2 3     P18 Component Of Aminoacyl-TRNA Synthetase Complex2
Multisynthase Complex Auxiliary Component P182 3     Elongation Factor P183
AIMP32 3     

External Ids:    HGNC: 32121   Entrez Gene: 95212   Ensembl: ENSG000001248027   OMIM: 6092065   UniProtKB: O433243   

Export aliases for EEF1E1 gene to outside databases

Previous GC identifer: GC06M008064


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for EEF1E1 Gene:
This gene encodes a multifunctional protein that localizes to both the cytoplasm and nucleus. In the cytoplasm,
the encoded protein is an auxiliary component of the macromolecular aminoacyl-tRNA synthase complex. However, its
mouse homolog has been shown to translocate to the nucleus in response to DNA damage, and it plays a positive
role in ATM/ATR-mediated p53 activation. Alternative splicing results in multiple transcript variants.
Read-through transcription also exists between this gene and the neighboring downstream MUTED (muted homolog)
gene. An EEF1E1-related pseudogene has been identified on chromosome 2. (provided by RefSeq, Dec 2010)

GeneCards Summary for EEF1E1 Gene:
EEF1E1 (eukaryotic translation elongation factor 1 epsilon 1) is a protein-coding gene. Diseases associated with EEF1E1 include norwegian scabies, and scabies. An important paralog of this gene is EEF1E1-BLOC1S5.

UniProtKB/Swiss-Prot: MCA3_HUMAN, O43324
Function: Positive modulator of ATM response to DNA damage

Gene Wiki entry for EEF1E1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the EEF1E1 gene promoter:
         CREB   TBP   LHX3b/Lhx3b   Sp1   deltaCREB   TFIID   LHX3a/Lhx3a   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEEF1E1 promoter sequence
   Search Chromatin IP Primers for EEF1E1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EEF1E1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p24.3   Ensembl cytogenetic band:  6p24.3   HGNC cytogenetic band: 6p24.3

EEF1E1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EEF1E1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M008024:  view genomic region     (about GC identifiers)

Start:
8,073,593 bp from pter      End:
8,102,828 bp from pter
Size:
29,236 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MCA3_HUMAN, O43324 (See protein sequence)
Recommended Name: Eukaryotic translation elongation factor 1 epsilon-1  
Size: 174 amino acids; 19811 Da
Subunit: Component of the multisynthase complex which is comprised of a bifunctional glutamyl-prolyl-tRNA
synthase, the monospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, arginyl and aspartyl-tRNA synthases,
and three auxiliary proteins, EEF1E1/p18, AIMP2/p38 and AIMP1/p43. Interacts with ATM and ATR. The interaction
with ATM, which takes place independently of TP53, is induced by DNA damage that may occur during genotoxic
stress or cell growth. The interaction with ATR is enhanced by UV irradiation
3 PDB 3D structures from and Proteopedia for EEF1E1:
2UZ8 (3D)        4BJV (3D)        4BJW (3D)    
Secondary accessions: C9JLK5 Q5THS2
Alternative splicing: 2 isoforms:  O43324-1   O43324-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for EEF1E1: NX_O43324

Explore proteomics data for EEF1E1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys12
  • Modification sites at PhosphoSitePlus

  • See EEF1E1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001129122.1  NP_004271.1  

    ENSEMBL proteins: 
     ENSP00000414363   ENSP00000427572   ENSP00000369038   ENSP00000424222   ENSP00000427143  
     ENSP00000425577  
    Reactome Protein details: O43324

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR010987 Glutathione-S-Trfase_C-like

    Graphical View of Domain Structure for InterPro Entry O43324

    ProtoNet protein and cluster: O43324

    UniProtKB/Swiss-Prot: MCA3_HUMAN, O43324
    Similarity: Contains 1 GST C-terminal domain


    EEF1E1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MCA3_HUMAN, O43324
    Function: Positive modulator of ATM response to DNA damage
    Induction: By DNA damaging agents such as UV, adriamycin, actinomycin-D and cisplatin

         Genatlas biochemistry entry for EEF1E1:
    eukaryotic translation elongation factor 1,epsilon 1

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    EEF1E1 for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Eef1e1):
     cellular  hematopoietic system  immune system  mortality/aging  tumorigenesis 

    EEF1E1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EEF1E1
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    miRNA
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    miRTarBase miRNAs that target EEF1E1:
    hsa-mir-155-5p (MIRT020944), hsa-let-7b-5p (MIRT032471)

    Block miRNA regulation of human, mouse, rat EEF1E1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate EEF1E1:
    hsa-miR-204 hsa-miR-211
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    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MCA3_HUMAN, O43324: Cytoplasm. Nucleus. Note=Cytoplasmic under growth arrest conditions. Translocated into the
    nucleus when growth resumes (S phase) and following DNA damage
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ISS--
    GO:0005829cytosol TAS--

    EEF1E1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for EEF1E1 About    
    See pathways by source

    SuperPathContained pathways About
    1tRNA Aminoacylation
    tRNA Aminoacylation0.57
    Cytosolic tRNA aminoacylation0.57
    2Gene Expression
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for EEF1E1
        Cytosolic tRNA aminoacylation



    EEF1E1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for EEF1E1
    Interactions:

        GeneGlobe Interaction Network for EEF1E1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for EEF1E1 (O433241, 3 ENSP000003690384) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATMQ133153, ENSP000002786164I2D: score=3 STRING: ENSP00000278616
    ATRQ135353, ENSP000003437414I2D: score=3 STRING: ENSP00000343741
    ARF6P623303, ENSP000002983164I2D: score=1 STRING: ENSP00000298316
    EIF1BO607393, ENSP000002329054I2D: score=1 STRING: ENSP00000232905
    NAT9Q9BTE03I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006418tRNA aminoacylation for protein translation TAS--
    GO:0008285negative regulation of cell proliferation ISS--
    GO:0010467gene expression TAS--
    GO:0043065positive regulation of apoptotic process ISS--
    GO:0043517positive regulation of DNA damage response, signal transduction by p53 class mediator ISS--

    EEF1E1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EEF1E1 (MCA3)

    2 Novoseek inferred chemical compound relationships for EEF1E1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    aminoacyl-trna 84.6 1 16169847 (1)
    trna 60.6 1 17303557 (1)



    EEF1E1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for EEF1E1 gene (2 alternative transcripts): 
    NM_001135650.1  NM_004280.4  

    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000429723(uc011dic.2) ENST00000502429 ENST00000379715(uc003mxz.3)
    ENST00000507463 ENST00000515633 ENST00000488226
    miRNA
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    hsa-miR-204 hsa-miR-211
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      QuantiTect SYBR Green Assays in human, mouse, rat EEF1E1
      QuantiFast Probe-based Assays in human, mouse, rat EEF1E1

    Selected AceView cDNA sequences (see all 1254):

    CB119976 AA608672 AA453555 BQ888963 BQ680246 CA417477 BQ677165 AA573738 
    BX094124 BU502705 BQ920500 BE254196 BQ676717 N70625 BX358208 AA557268 
    BU624061 BU931967 BI833321 BU931715 BE741557 BU542424 BM979416 BQ669772 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for EEF1E1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6
    SP1:                                -           -     -               
    SP2:                                -           -     -     -         
    SP3:                                -                                 
    SP4:                                                                  


    ECgene alternative splicing isoforms for EEF1E1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EEF1E1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCATACAGAA
    EEF1E1 Expression
    About this image

    EEF1E1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EEF1E1 Protein Expression

    UniProtKB/Swiss-Prot: MCA3_HUMAN, O43324
    Tissue specificity: Down-regulated in various cancer tissues

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for EEF1E1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Eef1e11 , 5 eukaryotic translation elongation factor 1 epsilon more1, 5 86.59(n)1
    88.51(a)1
      13 (18.38 cM)5
    661431  NM_025380.21  NP_079656.11 
     386456985 
    chicken
    (Gallus gallus)
    Aves EEF1E11 eukaryotic translation elongation factor 1 epsilon more 75.86(n)
    77.59(a)
      420865  XM_418953.4  XP_418953.4 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    79(a)
    1 → many
    GL343209.1(990143-1000707)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.76612 Xenopus laevis transcribed sequence with weak similarity more 75.44(n)    BJ093442.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BI475585.12   -- 70.76(n)    BI475585.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG301856
    --
    30(a)
    1 → many
    2R(19431564-19432422)


    ENSEMBL Gene Tree for EEF1E1 (if available)
    TreeFam Gene Tree for EEF1E1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for EEF1E1 gene
    EEF1E1-BLOC1S52  
    Selected SIMAP similar genes for EEF1E1 using alignment to 5 protein entries:     MCA3_HUMAN (see all proteins) (see all similar genes):
    FLJ00047    SUV420H1    EEF1E1-BLOC1S5    TGM4    BIRC3    SMYD4
    HINFP    NDUFS3    NEK4    ARIH1    ARL6IP5    C12orf76
    EIF3G    TAF2    TBCB    TNNT1    pp12301    ACTR10

    EEF1E1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for EEF1E1
    PGOHUM00000240865


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for EEF1E1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2672674CNV Deletion23128226
    esv2731544CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing EEF1E1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609206    OMIM disorders: --

    9 diseases for EEF1E1:    
    About MalaCards
    norwegian scabies    scabies    appendicitis    platelet storage pool deficiency
    progeria    hermansky-pudlak syndrome    colorectal cancer    hiv-1
    neuronitis


    EEF1E1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): EEF1E1
    Human Genome Epidemiology (HuGE) Navigator: EEF1E1 (2 documents)

    Export disorders for EEF1E1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EEF1E1 gene, integrated from 10 sources (see all 40):
    (articles sorted by number of sources associating them with EEF1E1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full- length cDNA cloning. (PubMed id 9653160)1, 2, 3 Mao M.... Chen Z. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    2. The haploinsufficient tumor suppressor p18 upregulates p53 via interactions with ATM/ATR. (PubMed id 15680327)1, 2, 9 Park B.-J.... Kim S. (Cell 2005)
    3. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (Alcohol. Clin. Exp. Res. 2010)
    4. Determination of three-dimensional structure and residues of the novel tumor suppressor AIMP3/p18 required for the interaction with ATM. (PubMed id 18343821)1, 2 Kim K.J.... Kang B.S. (J. Biol. Chem. 2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    7. Absence of somatic mutation of a tumor suppressor gene eukaryotic translation elongation factor 1, epsilon-1 (EEF1E1), in common human cancers. (PubMed id 19024604)1, 9 Kim M.S....Lee S.H. (APMIS 2008)
    8. Genetics of coronary artery calcification among African Americans, a meta-analysis. (PubMed id 23870195)1 Wojczynski M.K....Reilly M.P. (BMC Med. Genet. 2013)
    9. Contributions of aminoacyl-tRNA synthetase-interacting multifunctional protein-3 to mammalian translation initiation. (PubMed id 23306449)1 Ku M.J. and Lee S.Y. (Amino Acids 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9521 HGNC: 3212 AceView: EEF1E1 Ensembl:ENSG00000124802 euGenes: HUgn9521
    ECgene: EEF1E1 H-InvDB: EEF1E1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for EEF1E1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EEF1E1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for EEF1E1 gene:
    Search GeneIP for patents involving EEF1E1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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