Free for academic non-profit institutions. Other users need a Commercial license

Aliases for EEF1D Gene

Aliases for EEF1D Gene

  • Eukaryotic Translation Elongation Factor 1 Delta 2 3 5
  • Eukaryotic Translation Elongation Factor 1 Delta (Guanine Nucleotide Exchange Protein) 2 3
  • Antigen NY-CO-4 3 4
  • EF-1-Delta 3 4
  • EF1D 3 4
  • Elongation Factor 1-Delta 3
  • FP1047 3
  • EF-1D 3

External Ids for EEF1D Gene

Previous GeneCards Identifiers for EEF1D Gene

  • GC19U990032
  • GC08M144889
  • GC08M144436
  • GC08M144767
  • GC08M144733
  • GC08M144661
  • GC08M139913

Summaries for EEF1D Gene

Entrez Gene Summary for EEF1D Gene

  • This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit, delta, functions as guanine nucleotide exchange factor. It is reported that following HIV-1 infection, this subunit interacts with HIV-1 Tat. This interaction results in repression of translation of host cell proteins and enhanced translation of viral proteins. Several alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. Related pseudogenes have been defined on chromosomes 1, 6, 7, 9, 11, 13, 17, 19.[provided by RefSeq, Aug 2010]

GeneCards Summary for EEF1D Gene

EEF1D (Eukaryotic Translation Elongation Factor 1 Delta) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Influenza A. GO annotations related to this gene include signal transducer activity and translation factor activity, RNA binding. An important paralog of this gene is EEF1B2.

UniProtKB/Swiss-Prot for EEF1D Gene

  • Isoform 1: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1-alpha for another round of transfer of aminoacyl-tRNAs to the ribosome.

  • Isoform 2: Regulates induction of heat-shock-responsive genes through association with heat shock transcription factors and direct DNA-binding at heat shock promoter elements (HSE).

Gene Wiki entry for EEF1D Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EEF1D Gene

Genomics for EEF1D Gene

Regulatory Elements for EEF1D Gene

Enhancers for EEF1D Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G143890 1.1 Ensembl dbSUPER 7.7 -291.9 -291938 1.4 PKNOX1 MLX NFIB ARID4B DMAP1 RARA SLC30A9 MIXL1 THAP11 SP5 PLEC EEF1D TOP1MT EPPK1 PIR31533
GH08G144046 1.3 Ensembl ENCODE dbSUPER 4.3 -450.4 -450441 6.7 AGO1 ARID4B ZNF76 PCBP1 PAF1 ZNF263 REST KAT8 NFIC GLIS1 ZNF251 LRRC14 ZNF517 ZNF250 LOC105375803 TMED10P1 ENSG00000255224 GPAA1 ENSG00000255164 CYC1
GH08G143275 1.8 FANTOM5 ENCODE dbSUPER 2.9 +320.5 320467 6.5 CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 TBX21 MINCR ZFP41 ZNF623 RHPN1 HGH1 FAM83H-AS1 TOP1MT ZC3H3 TIGD5 GLI4
GH08G143914 2.2 FANTOM5 Ensembl ENCODE dbSUPER 1.1 -337.6 -337590 45.2 CREB3L1 MLX AGO1 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 PLEC ZNF251 ZNF517 ZNF250 LOC105375803 LRRC14 ZNF696 ZNF34 ZNF623 CYHR1
GH08G143964 1.5 FANTOM5 Ensembl ENCODE dbSUPER 1.5 -366.6 -366607 3.6 PKNOX1 FOXA2 SIN3A CEBPG ZBTB7B HIC1 CTBP1 GATA3 RCOR1 HCFC1 PLEC PARP10 SPATC1 EXOSC4 ENSG00000255224 EPPK1 PUF60 C8orf82 C8orf31 EEF1D
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EEF1D on UCSC Golden Path with GeneCards custom track

Promoters for EEF1D Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000232117 1741 2401 HDGF PKNOX1 MLX CREB3L1 AGO1 ZFP64 ARID4B SIN3A DMAP1 ZNF2

Genomic Location for EEF1D Gene

Chromosome:
8
Start:
143,579,697 bp from pter
End:
143,599,541 bp from pter
Size:
19,845 bases
Orientation:
Minus strand

Genomic View for EEF1D Gene

Genes around EEF1D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EEF1D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EEF1D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EEF1D Gene

Proteins for EEF1D Gene

  • Protein details for EEF1D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29692-EF1D_HUMAN
    Recommended name:
    Elongation factor 1-delta
    Protein Accession:
    P29692
    Secondary Accessions:
    • B4DDU4
    • D3DWK3
    • E9PBQ9
    • Q4VBZ6
    • Q969J1
    • Q96I38

    Protein attributes for EEF1D Gene

    Size:
    281 amino acids
    Molecular mass:
    31122 Da
    Quaternary structure:
    • EF-1 is composed of 4 subunits: alpha, beta, delta isoform 1, and gamma. Isoform 2 interacts with HSF1 and NFE2L2.

    Three dimensional structures from OCA and Proteopedia for EEF1D Gene

    Alternative splice isoforms for EEF1D Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EEF1D Gene

Post-translational modifications for EEF1D Gene

  • Ubiquitination at isoforms=2, 3, 410, isoforms=2, 3, 415, Lys59, Lys107, and isoforms=2, 3, 4232
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for EEF1D

No data available for DME Specific Peptides for EEF1D Gene

Domains & Families for EEF1D Gene

Graphical View of Domain Structure for InterPro Entry

P29692

UniProtKB/Swiss-Prot:

EF1D_HUMAN :
  • Belongs to the EF-1-beta/EF-1-delta family.
Family:
  • Belongs to the EF-1-beta/EF-1-delta family.
genes like me logo Genes that share domains with EEF1D: view

No data available for Gene Families for EEF1D Gene

Function for EEF1D Gene

Molecular function for EEF1D Gene

GENATLAS Biochemistry:
eukaryotic translation elongation factor 1,delta
UniProtKB/Swiss-Prot Function:
Isoform 1: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1-alpha for another round of transfer of aminoacyl-tRNAs to the ribosome.
UniProtKB/Swiss-Prot Function:
Isoform 2: Regulates induction of heat-shock-responsive genes through association with heat shock transcription factors and direct DNA-binding at heat shock promoter elements (HSE).
UniProtKB/Swiss-Prot Induction:
By homocysteine (HC), may mediate accelerated synthesis of free thiol-containing proteins in response to HC-induced oxidative stress. Also induced following exposure to ionizing radiation.

Gene Ontology (GO) - Molecular Function for EEF1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003746 translation elongation factor activity IEA --
GO:0004871 signal transducer activity IMP 12761501
GO:0005515 protein binding IPI 16169070
GO:0008135 translation factor activity, RNA binding TAS 8334168
genes like me logo Genes that share ontologies with EEF1D: view
genes like me logo Genes that share phenotypes with EEF1D: view

Animal Model Products

CRISPR Products

miRNA for EEF1D Gene

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for EEF1D

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EEF1D Gene

Localization for EEF1D Gene

Subcellular locations from UniProtKB/Swiss-Prot for EEF1D Gene

Isoform 2: Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EEF1D gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for EEF1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IDA --
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm IDA 8743958
GO:0005783 colocalizes_with endoplasmic reticulum IDA 8743958
GO:0005829 cytosol IDA,TAS --
genes like me logo Genes that share ontologies with EEF1D: view

Pathways & Interactions for EEF1D Gene

genes like me logo Genes that share pathways with EEF1D: view

Pathways by source for EEF1D Gene

1 BioSystems pathway for EEF1D Gene
1 KEGG pathway for EEF1D Gene

SIGNOR curated interactions for EEF1D Gene

Other effect:

Gene Ontology (GO) - Biological Process for EEF1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006412 translation IEA --
GO:0006414 translational elongation IEA,TAS --
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with EEF1D: view

Drugs & Compounds for EEF1D Gene

(5) Drugs for EEF1D Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(4) Additional Compounds for EEF1D Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with EEF1D: view

Transcripts for EEF1D Gene

Unigene Clusters for EEF1D Gene

Eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for EEF1D

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EEF1D Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e · 9f · 9g · 9h · 9i ·
SP1: - - - - - - - - - - - - - - - - - - - - - - -
SP2: - - - - - - - - - - - - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - - - - - - - -
SP5:
SP6:
SP7: - - - - - - - - - - - - - - - - - - - - - -
SP8: - - - - - - - - - - - - - - - - - - - - - -
SP9: - - - - - - - - - - - - - - - - - -
SP10: - - - - - - - - - - - - - - - - -
SP11: - - - - - - - - - - - - - -
SP12:
SP13: - - - - - - - - -
SP14: - - - - -
SP15: - - - - - - - - -
SP16: - - - - - - - -
SP17:
SP18:
SP19: - - - - - - - - -
SP20: - - - - - - - - - -
SP21: - - - - - - - - - - - - -
SP22: - - - - - - - -
SP23: - - - - - - - - - - - -
SP24: - - - - - - - - - - - -
SP25: - - - - - - - - - - - - - - - - - - - - - -
SP26: - - - - - - - - - - - - - -
SP27: - - - - - - - - - - - -
SP28: - - -
SP29: - - - - - - - - - - -

ExUns: 9j ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c · 16d ^ 17a · 17b ^ 18
SP1: - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - -
SP5: - -
SP6:
SP7: - - - -
SP8: - - - -
SP9: - - - -
SP10: - - - -
SP11: - - - -
SP12:
SP13:
SP14:
SP15:
SP16:
SP17: -
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25: - - - - -
SP26:
SP27:
SP28:
SP29: - -

Relevant External Links for EEF1D Gene

GeneLoc Exon Structure for
EEF1D
ECgene alternative splicing isoforms for
EEF1D

Expression for EEF1D Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EEF1D Gene

Protein differential expression in normal tissues from HIPED for EEF1D Gene

This gene is overexpressed in Bone marrow stromal cell (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EEF1D Gene



Protein tissue co-expression partners for EEF1D Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EEF1D Gene:

EEF1D

SOURCE GeneReport for Unigene cluster for EEF1D Gene:

Hs.686554

mRNA Expression by UniProt/SwissProt for EEF1D Gene:

P29692-EF1D_HUMAN
Tissue specificity: Isoform 2 is specifically expressed in brain, cerebellum and testis.

Evidence on tissue expression from TISSUES for EEF1D Gene

  • Lung(4.9)
  • Skin(4.9)
  • Nervous system(4.9)
  • Liver(4.6)
  • Muscle(4.6)
  • Blood(4.5)
  • Bone(4.4)
  • Eye(4.3)
  • Pancreas(4.3)
  • Intestine(3.4)
  • Stomach(3.3)
  • Kidney(3)
  • Lymph node(2.5)
  • Bone marrow(2.4)
  • Spleen(2.4)
  • Adrenal gland(2.3)
  • Heart(2.3)
  • Gall bladder(2.2)
  • Thyroid gland(2.2)
genes like me logo Genes that share expression patterns with EEF1D: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for EEF1D Gene

Orthologs for EEF1D Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EEF1D Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EEF1D 35 34
  • 99.29 (n)
OneToOne
cow
(Bos Taurus)
Mammalia EEF1D 35 34
  • 88.33 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LOC475115 34
  • 85.46 (n)
EEF1D 35
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eef1d 34
  • 84.52 (n)
mouse
(Mus musculus)
Mammalia Eef1d 34 16 35
  • 84.34 (n)
oppossum
(Monodelphis domestica)
Mammalia EEF1D 35
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EEF1D 35
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves EEF1D 35 34
  • 61.61 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EEF1D 35
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eef1d 34
  • 69.7 (n)
Str.3183 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.1169 34
zebrafish
(Danio rerio)
Actinopterygii eef1db 35 34
  • 66.3 (n)
OneToMany
eef1da 35
  • 53 (a)
OneToMany
wufa14f09 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11170 34
fruit fly
(Drosophila melanogaster)
Insecta eEF1delta 34 35
  • 57.01 (n)
eEF1dgr 36
  • 48 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004235 34
  • 56.97 (n)
worm
(Caenorhabditis elegans)
Secernentea eef-1B.2 34
  • 57.61 (n)
Y41E3.10 36
  • 46 (a)
eef-1B.1 35
  • 45 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EFB1 35
  • 42 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os.183 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11191 35
  • 46 (a)
OneToOne
Species where no ortholog for EEF1D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EEF1D Gene

ENSEMBL:
Gene Tree for EEF1D (if available)
TreeFam:
Gene Tree for EEF1D (if available)

Paralogs for EEF1D Gene

Paralogs for EEF1D Gene

genes like me logo Genes that share paralogs with EEF1D: view

Variants for EEF1D Gene

Sequence variations from dbSNP and Humsavar for EEF1D Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000194917 -- 143,586,019(+) AGCAC(A/G)GAAGG intron-variant
rs1000483257 -- 143,585,232(+) CCTGG(A/G)GGCCC intron-variant
rs1000524089 -- 143,585,005(+) CCTGA(C/T)TGGAT intron-variant
rs1000551410 -- 143,597,910(+) TGTAC(A/C)CCGCG upstream-variant-2KB, reference, missense
rs1000556740 -- 143,585,286(+) GGTTC(A/G)AGAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EEF1D Gene

Variant ID Type Subtype PubMed ID
dgv12410n54 CNV loss 21841781
dgv12418n54 CNV loss 21841781
dgv12419n54 CNV loss 21841781
dgv12420n54 CNV gain 21841781
dgv12421n54 CNV gain 21841781
dgv12422n54 CNV gain 21841781
dgv7336n100 CNV gain 25217958
esv26007 CNV loss 19812545
nsv1161809 CNV deletion 26073780
nsv1161810 CNV deletion 26073780
nsv466000 CNV loss 19166990
nsv466004 CNV loss 19166990
nsv470247 CNV loss 18288195
nsv470248 CNV gain 18288195
nsv516210 CNV loss 19592680
nsv612774 CNV loss 21841781
nsv612777 CNV gain 21841781
nsv612793 CNV loss 21841781
nsv612812 CNV loss 21841781
nsv612813 CNV loss 21841781
nsv612819 CNV gain 21841781
nsv612820 CNV loss 21841781
nsv612822 CNV gain 21841781
nsv824771 CNV gain 20364138
nsv831488 CNV loss 17160897
nsv950013 CNV deletion 24416366

Variation tolerance for EEF1D Gene

Residual Variation Intolerance Score: 95.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.92; 67.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EEF1D Gene

Human Gene Mutation Database (HGMD)
EEF1D
SNPedia medical, phenotypic, and genealogical associations of SNPs for
EEF1D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EEF1D Gene

Disorders for EEF1D Gene

Relevant External Links for EEF1D

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EEF1D

No disorders were found for EEF1D Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EEF1D Gene

Publications for EEF1D Gene

  1. The human leucine zipper-containing guanine-nucleotide exchange protein elongation factor-1 delta. (PMID: 8334168) Sanders J.P. … Moeller W. (Biochim. Biophys. Acta 1993) 2 3 4 22 64
  2. Induction of acute translational response genes by homocysteine. Elongation factors-1alpha, -beta, and -delta. (PMID: 9677419) Chacko G. … Hajjar K.A. (J. Biol. Chem. 1998) 3 4 22 64
  3. Elongation factor 1 delta is enhanced following exposure to ionizing radiation. (PMID: 8168075) Jung M. … Dritschilo A. (Cancer Res. 1994) 3 4 22 64
  4. Transformation of eEF1Bdelta into heat-shock response transcription factor by alternative splicing. (PMID: 21597468) Kaitsuka T. … Matsushita M. (EMBO Rep. 2011) 3 4 64
  5. Unbiased functional proteomics strategy for protein kinase inhibitor validation and identification of bona fide protein kinase substrates: application to identification of as a substrate for CK2. (PMID: 21936567) Gyenis L. … Litchfield D.W. (J. Proteome Res. 2011) 3 4 64

Products for EEF1D Gene

Sources for EEF1D Gene

Content
Loading form....