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Aliases for EEF1D Gene

Aliases for EEF1D Gene

  • Eukaryotic Translation Elongation Factor 1 Delta 2 3
  • Eukaryotic Translation Elongation Factor 1 Delta (Guanine Nucleotide Exchange Protein) 2 3 5
  • Antigen NY-CO-4 3 4
  • EF-1-Delta 3 4
  • EF1D 3 4
  • Guanine Nucleotide Exchange Protein 3
  • FP1047 3
  • EF-1D 3

External Ids for EEF1D Gene

Previous GeneCards Identifiers for EEF1D Gene

  • GC19U990032
  • GC08M144889
  • GC08M144436
  • GC08M144767
  • GC08M144733
  • GC08M144661
  • GC08M139913

Summaries for EEF1D Gene

Entrez Gene Summary for EEF1D Gene

  • This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit, delta, functions as guanine nucleotide exchange factor. It is reported that following HIV-1 infection, this subunit interacts with HIV-1 Tat. This interaction results in repression of translation of host cell proteins and enhanced translation of viral proteins. Several alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. Related pseudogenes have been defined on chromosomes 1, 6, 7, 9, 11, 13, 17, 19.[provided by RefSeq, Aug 2010]

GeneCards Summary for EEF1D Gene

EEF1D (Eukaryotic Translation Elongation Factor 1 Delta) is a Protein Coding gene. Diseases associated with EEF1D include cystic echinococcosis. Among its related pathways are Gene Expression and Transport to the Golgi and subsequent modification. GO annotations related to this gene include signal transducer activity and translation factor activity, RNA binding. An important paralog of this gene is EEF1B2.

UniProtKB/Swiss-Prot for EEF1D Gene

  • Isoform 1: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1-alpha for another round of transfer of aminoacyl-tRNAs to the ribosome.

  • Isoform 2: Regulates induction of heat-shock-responsive genes through association with heat shock transcription factors and direct DNA-binding at heat shock promoter elements (HSE).

Gene Wiki entry for EEF1D Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EEF1D Gene

Genomics for EEF1D Gene

Regulatory Elements for EEF1D Gene

Promoters for EEF1D Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EEF1D on UCSC Golden Path with GeneCards custom track

Genomic Location for EEF1D Gene

Chromosome:
8
Start:
143,579,697 bp from pter
End:
143,599,541 bp from pter
Size:
19,845 bases
Orientation:
Minus strand

Genomic View for EEF1D Gene

Genes around EEF1D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EEF1D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EEF1D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EEF1D Gene

Proteins for EEF1D Gene

  • Protein details for EEF1D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29692-EF1D_HUMAN
    Recommended name:
    Elongation factor 1-delta
    Protein Accession:
    P29692
    Secondary Accessions:
    • B4DDU4
    • D3DWK3
    • E9PBQ9
    • Q4VBZ6
    • Q969J1
    • Q96I38

    Protein attributes for EEF1D Gene

    Size:
    281 amino acids
    Molecular mass:
    31122 Da
    Quaternary structure:
    • EF-1 is composed of 4 subunits: alpha, beta, delta isoform 1, and gamma. Isoform 2 interacts with HSF1 and NFE2L2.

    Three dimensional structures from OCA and Proteopedia for EEF1D Gene

    Alternative splice isoforms for EEF1D Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EEF1D Gene

Proteomics data for EEF1D Gene at MOPED

Post-translational modifications for EEF1D Gene

  • Ubiquitination at Lys 10, Lys 15, Lys 59, Lys 107, and Lys 232
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for EEF1D Gene

Domains & Families for EEF1D Gene

Graphical View of Domain Structure for InterPro Entry

P29692

UniProtKB/Swiss-Prot:

EF1D_HUMAN :
  • Belongs to the EF-1-beta/EF-1-delta family.
Family:
  • Belongs to the EF-1-beta/EF-1-delta family.
genes like me logo Genes that share domains with EEF1D: view

No data available for Gene Families for EEF1D Gene

Function for EEF1D Gene

Molecular function for EEF1D Gene

GENATLAS Biochemistry:
eukaryotic translation elongation factor 1,delta
UniProtKB/Swiss-Prot Function:
Isoform 1: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1-alpha for another round of transfer of aminoacyl-tRNAs to the ribosome.
UniProtKB/Swiss-Prot Function:
Isoform 2: Regulates induction of heat-shock-responsive genes through association with heat shock transcription factors and direct DNA-binding at heat shock promoter elements (HSE).
UniProtKB/Swiss-Prot Induction:
By homocysteine (HC), may mediate accelerated synthesis of free thiol-containing proteins in response to HC-induced oxidative stress. Also induced following exposure to ionizing radiation.

Gene Ontology (GO) - Molecular Function for EEF1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16169070
genes like me logo Genes that share ontologies with EEF1D: view
genes like me logo Genes that share phenotypes with EEF1D: view

Animal Model Products

  • Taconic Biosciences Mouse Models for EEF1D

miRNA for EEF1D Gene

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EEF1D Gene

Localization for EEF1D Gene

Subcellular locations from UniProtKB/Swiss-Prot for EEF1D Gene

Isoform 2: Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EEF1D Gene COMPARTMENTS Subcellular localization image for EEF1D gene
Compartment Confidence
cytosol 5
nucleus 5
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for EEF1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005853 eukaryotic translation elongation factor 1 complex IEA --
genes like me logo Genes that share ontologies with EEF1D: view

Pathways & Interactions for EEF1D Gene

genes like me logo Genes that share pathways with EEF1D: view

Pathways by source for EEF1D Gene

1 BioSystems pathway for EEF1D Gene
1 KEGG pathway for EEF1D Gene

SIGNOR curated interactions for EEF1D Gene

Other effect:

Gene Ontology (GO) - Biological Process for EEF1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007165 signal transduction IMP 12761501
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP 12761501
GO:0071479 cellular response to ionizing radiation IDA 8168075
genes like me logo Genes that share ontologies with EEF1D: view

Drugs & Compounds for EEF1D Gene

(5) Drugs for EEF1D Gene - From: Novoseek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(4) Additional Compounds for EEF1D Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with EEF1D: view

Transcripts for EEF1D Gene

Unigene Clusters for EEF1D Gene

Eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EEF1D Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e · 9f · 9g · 9h · 9i ·
SP1: - - - - - - - - - - - - - - - - - - - - - - -
SP2: - - - - - - - - - - - - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - - - - - - - -
SP5:
SP6:
SP7: - - - - - - - - - - - - - - - - - - - - - -
SP8: - - - - - - - - - - - - - - - - - - - - - -
SP9: - - - - - - - - - - - - - - - - - -
SP10: - - - - - - - - - - - - - - - - -
SP11: - - - - - - - - - - - - - -
SP12:
SP13: - - - - - - - - -
SP14: - - - - -
SP15: - - - - - - - - -
SP16: - - - - - - - -
SP17:
SP18:
SP19: - - - - - - - - -
SP20: - - - - - - - - - -
SP21: - - - - - - - - - - - - -
SP22: - - - - - - - -
SP23: - - - - - - - - - - - -
SP24: - - - - - - - - - - - -
SP25: - - - - - - - - - - - - - - - - - - - - - -
SP26: - - - - - - - - - - - - - -
SP27: - - - - - - - - - - - -
SP28: - - -
SP29: - - - - - - - - - - -

ExUns: 9j ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c · 16d ^ 17a · 17b ^ 18
SP1: - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - -
SP5: - -
SP6:
SP7: - - - -
SP8: - - - -
SP9: - - - -
SP10: - - - -
SP11: - - - -
SP12:
SP13:
SP14:
SP15:
SP16:
SP17: -
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25: - - - - -
SP26:
SP27:
SP28:
SP29: - -

Relevant External Links for EEF1D Gene

GeneLoc Exon Structure for
EEF1D
ECgene alternative splicing isoforms for
EEF1D

Expression for EEF1D Gene

mRNA expression in normal human tissues for EEF1D Gene

Protein differential expression in normal tissues from HIPED for EEF1D Gene

This gene is overexpressed in Bone marrow stromal cell (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EEF1D Gene



SOURCE GeneReport for Unigene cluster for EEF1D Gene Hs.686554

mRNA Expression by UniProt/SwissProt for EEF1D Gene

P29692-EF1D_HUMAN
Tissue specificity: Isoform 2 is specifically expressed in brain, cerebellum and testis.
genes like me logo Genes that share expression patterns with EEF1D: view

Protein tissue co-expression partners for EEF1D Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for EEF1D Gene

Orthologs for EEF1D Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EEF1D Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EEF1D 35
  • 99.29 (n)
  • 99.64 (a)
EEF1D 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EEF1D 36
  • 92 (a)
OneToOne
EEF1D 35
  • 88.33 (n)
  • 92.14 (a)
dog
(Canis familiaris)
Mammalia LOC475115 35
  • 85.46 (n)
  • 85.2 (a)
EEF1D 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eef1d 16
Eef1d 36
  • 84 (a)
OneToOne
Eef1d 35
  • 84.34 (n)
  • 85.16 (a)
oppossum
(Monodelphis domestica)
Mammalia EEF1D 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EEF1D 36
  • 54 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eef1d 35
  • 84.52 (n)
  • 86.84 (a)
chicken
(Gallus gallus)
Aves EEF1D 36
  • 50 (a)
OneToOne
EEF1D 35
  • 61.61 (n)
  • 57.74 (a)
lizard
(Anolis carolinensis)
Reptilia EEF1D 36
  • 54 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1169 35
tropical clawed frog
(Silurana tropicalis)
Amphibia eef1d 35
  • 69.7 (n)
  • 67.77 (a)
Str.3183 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11170 35
zebrafish
(Danio rerio)
Actinopterygii eef1da 36
  • 53 (a)
OneToMany
eef1db 36
  • 42 (a)
OneToMany
eef1db 35
  • 66.3 (n)
  • 65.82 (a)
wufa14f09 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004235 35
  • 56.97 (n)
  • 48.51 (a)
fruit fly
(Drosophila melanogaster)
Insecta eEF1delta 36
  • 49 (a)
OneToOne
eEF1dgr 37
  • 48 (a)
eEF1delta 35
  • 57.01 (n)
  • 55.56 (a)
worm
(Caenorhabditis elegans)
Secernentea eef-1B.2 35
  • 57.61 (n)
  • 53.8 (a)
eef-1B.1 36
  • 45 (a)
OneToMany
Y41E3.10 37
  • 46 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EFB1 36
  • 42 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os.183 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11191 36
  • 46 (a)
OneToOne
Species with no ortholog for EEF1D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EEF1D Gene

ENSEMBL:
Gene Tree for EEF1D (if available)
TreeFam:
Gene Tree for EEF1D (if available)

Paralogs for EEF1D Gene

Paralogs for EEF1D Gene

genes like me logo Genes that share paralogs with EEF1D: view

Variants for EEF1D Gene

Sequence variations from dbSNP and Humsavar for EEF1D Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs751932 -- 143,590,371(+) CAATA(C/T)ATAAT intron-variant
rs2085019 -- 143,587,403(-) gcggt(A/G)agccg intron-variant
rs1563148 -- 143,582,149(-) GGCCT(C/G)AGTAT intron-variant
rs2382961 -- 143,584,725(+) CGAAC(A/T)TGCTG intron-variant
rs2382962 -- 143,587,222(+) tcact(A/G)aattt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EEF1D Gene

Variant ID Type Subtype PubMed ID
nsv470247 CNV Loss 18288195
nsv891676 CNV Loss 21882294
dgv7924n71 CNV Loss 21882294
dgv7928n71 CNV Loss 21882294
dgv7930n71 CNV Loss 21882294
dgv7932n71 CNV Loss 21882294
dgv7933n71 CNV Loss 21882294
nsv891716 CNV Gain 21882294
nsv891720 CNV Loss 21882294
dgv7934n71 CNV Loss 21882294
nsv516210 CNV Loss 19592680
nsv470248 CNV Gain 18288195
nsv891722 CNV Loss 21882294
dgv7935n71 CNV Loss 21882294
nsv466000 CNV Loss 19166990
dgv7936n71 CNV Loss 21882294
dgv7937n71 CNV Loss 21882294
nsv891734 CNV Loss 21882294
nsv891737 CNV Gain 21882294
nsv466004 CNV Loss 19166990
nsv891739 CNV Loss 21882294
nsv831488 CNV Loss 17160897
nsv824771 CNV Gain 20364138
esv26007 CNV Loss 19812545

Variation tolerance for EEF1D Gene

Residual Variation Intolerance Score: 95.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.92; 67.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EEF1D Gene

HapMap Linkage Disequilibrium report
EEF1D
Human Gene Mutation Database (HGMD)
EEF1D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EEF1D Gene

Disorders for EEF1D Gene

MalaCards: The human disease database

(1) MalaCards diseases for EEF1D Gene - From: GeneCards

Disorder Aliases PubMed IDs
cystic echinococcosis
  • echinococcus granulosus infection
- elite association - COSMIC cancer census association via MalaCards
Search EEF1D in MalaCards View complete list of genes associated with diseases

Relevant External Links for EEF1D

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EEF1D
genes like me logo Genes that share disorders with EEF1D: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EEF1D Gene

Publications for EEF1D Gene

  1. The human leucine zipper-containing guanine-nucleotide exchange protein elongation factor-1 delta. (PMID: 8334168) Sanders J.P. … Moeller W. (Biochim. Biophys. Acta 1993) 2 3 4 23 67
  2. Alternative expression and sequence of human elongation factor-1 delta during malignant transformation of human bronchial epithelial cells induced by cadmium chloride. (PMID: 20514991) Lei Y.X. … Lin H.Z. (Biomed. Environ. Sci. 2010) 3 23
  3. Clinical significance of elongation factor-1 delta mRNA expression in oesophageal carcinoma. (PMID: 15199388) Ogawa K. … Mori M. (Br. J. Cancer 2004) 3 23
  4. Identification of the interaction between the human recombinant histamine releasing factor/translationally controlled tumor protein and elongation factor-1 delta (also known as eElongation factor-1B beta). (PMID: 15062873) Langdon J.M. … MacDonald S.M. (Biochim. Biophys. Acta 2004) 3 23
  5. Conserved protein kinases encoded by herpesviruses and cellular protein kinase cdc2 target the same phosphorylation site in eukaryotic elongation factor 1delta. (PMID: 12551973) Kawaguchi Y. … Yamanashi Y. (J. Virol. 2003) 3 23

Products for EEF1D Gene

Sources for EEF1D Gene

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