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Aliases for EEF1B2 Gene

Aliases for EEF1B2 Gene

  • Eukaryotic Translation Elongation Factor 1 Beta 2 2 3
  • EF-1-Beta 3 4
  • EEF1B 3 4
  • EF1B 3 4
  • Eukaryotic Translation Elongation Factor 1 Beta 1 3
  • EEF1B1 3

External Ids for EEF1B2 Gene

Previous GeneCards Identifiers for EEF1B2 Gene

  • GC02P205241
  • GC02P205748
  • GC02P206988
  • GC02P207227
  • GC02P207228
  • GC02P206849
  • GC02P206732
  • GC02P207024

Summaries for EEF1B2 Gene

Entrez Gene Summary for EEF1B2 Gene

  • This gene encodes a translation elongation factor. The protein is a guanine nucleotide exchange factor involved in the transfer of aminoacylated tRNAs to the ribosome. Alternative splicing results in three transcript variants which differ only in the 5' UTR. [provided by RefSeq, Jul 2008]

GeneCards Summary for EEF1B2 Gene

EEF1B2 (Eukaryotic Translation Elongation Factor 1 Beta 2) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Gene Expression. GO annotations related to this gene include translation elongation factor activity. An important paralog of this gene is EEF1D.

UniProtKB/Swiss-Prot for EEF1B2 Gene

  • EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP

Gene Wiki entry for EEF1B2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EEF1B2 Gene

Genomics for EEF1B2 Gene

Regulatory Elements for EEF1B2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for EEF1B2 Gene

Chromosome:
2
Start:
206,159,585 bp from pter
End:
206,162,929 bp from pter
Size:
3,345 bases
Orientation:
Plus strand

Genomic View for EEF1B2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EEF1B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EEF1B2 Gene

Proteins for EEF1B2 Gene

  • Protein details for EEF1B2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24534-EF1B_HUMAN
    Recommended name:
    Elongation factor 1-beta
    Protein Accession:
    P24534
    Secondary Accessions:
    • A8K795
    • Q6IBH9

    Protein attributes for EEF1B2 Gene

    Size:
    225 amino acids
    Molecular mass:
    24764 Da
    Quaternary structure:
    • EF-1 is composed of 4 subunits: alpha, beta, delta, and gamma

    Three dimensional structures from OCA and Proteopedia for EEF1B2 Gene

neXtProt entry for EEF1B2 Gene

Proteomics data for EEF1B2 Gene at MOPED

Post-translational modifications for EEF1B2 Gene

  • Phosphorylation affects the GDP/GTP exchange rate
  • Ubiquitination at Lys 78 and Lys 147
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for EEF1B2 Gene

Domains & Families for EEF1B2 Gene

Suggested Antigen Peptide Sequences for EEF1B2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P24534

UniProtKB/Swiss-Prot:

EF1B_HUMAN :
  • Contains 1 GST C-terminal domain.
  • Belongs to the EF-1-beta/EF-1-delta family.
Domain:
  • Contains 1 GST C-terminal domain.
Family:
  • Belongs to the EF-1-beta/EF-1-delta family.
genes like me logo Genes that share domains with EEF1B2: view

No data available for Gene Families for EEF1B2 Gene

Function for EEF1B2 Gene

Molecular function for EEF1B2 Gene

GENATLAS Biochemistry:
eukaryotic translation elongation factor 1,beta 2,specifically transcribed in fetal brain and in skeletal muscle (multigene family)
UniProtKB/Swiss-Prot Function:
EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP
UniProtKB/Swiss-Prot Induction:
By homocysteine (HC), may mediate accelerated synthesis of free thiol-containing proteins in response to HC-induced oxidative stress.

Gene Ontology (GO) - Molecular Function for EEF1B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003746 translation elongation factor activity NAS 1886777
GO:0005515 protein binding IPI 16169070
genes like me logo Genes that share ontologies with EEF1B2: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EEF1B2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for EEF1B2 Gene

Localization for EEF1B2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EEF1B2 Gene COMPARTMENTS Subcellular localization image for EEF1B2 gene
Compartment Confidence
cytosol 4
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for EEF1B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 NOT nucleus IDA 12426392
GO:0005737 cytoplasm IDA 8743958
GO:0005783 colocalizes_with endoplasmic reticulum IDA 8743958
GO:0005829 cytosol TAS --
GO:0005853 eukaryotic translation elongation factor 1 complex NAS 1886777
genes like me logo Genes that share ontologies with EEF1B2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for EEF1B2 Gene

Pathways & Interactions for EEF1B2 Gene

genes like me logo Genes that share pathways with EEF1B2: view

Pathways by source for EEF1B2 Gene

1 BioSystems pathway for EEF1B2 Gene

Gene Ontology (GO) - Biological Process for EEF1B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation TAS --
GO:0006414 translational elongation TAS --
GO:0010467 gene expression TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with EEF1B2: view

No data available for SIGNOR curated interactions for EEF1B2 Gene

Drugs & Compounds for EEF1B2 Gene

(1) Drugs for EEF1B2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(4) Additional Compounds for EEF1B2 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Aminoacyl-tRNA
gdp
glyceraldehyde 3-phosphate
gtp
Partial agonist, Agonist
genes like me logo Genes that share compounds with EEF1B2: view

Transcripts for EEF1B2 Gene

Unigene Clusters for EEF1B2 Gene

Eukaryotic translation elongation factor 1 beta 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EEF1B2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EEF1B2 Gene

No ASD Table

Relevant External Links for EEF1B2 Gene

GeneLoc Exon Structure for
EEF1B2
ECgene alternative splicing isoforms for
EEF1B2

Expression for EEF1B2 Gene

mRNA expression in normal human tissues for EEF1B2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EEF1B2 Gene



SOURCE GeneReport for Unigene cluster for EEF1B2 Gene Hs.421608

genes like me logo Genes that share expression patterns with EEF1B2: view

Protein tissue co-expression partners for EEF1B2 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EEF1B2 Gene

Orthologs for EEF1B2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EEF1B2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EEF1B2 35
  • 91.11 (n)
  • 97.78 (a)
EEF1B 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EEF1B2 35
  • 93.04 (n)
  • 98.22 (a)
-- 36
  • 74 (a)
OneToMany
-- 36
  • 92 (a)
OneToMany
-- 36
  • 76 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Eef1b2 35
  • 89.19 (n)
  • 95.56 (a)
Eef1b2 16
Eef1b2 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EEF1B2 35
  • 99.85 (n)
  • 100 (a)
EEF1B2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eef1b2 35
  • 89.19 (n)
  • 94.67 (a)
oppossum
(Monodelphis domestica)
Mammalia EEF1B2 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EEF1B2 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves EEF1B2 35
  • 81.99 (n)
  • 93.3 (a)
EEF1B2 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EEF1B2 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eef1b2 35
  • 78.07 (n)
  • 85.33 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.20382 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
eef1b2 35
  • 73.81 (n)
  • 82.59 (a)
eef1b2 36
  • 79 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Ef1bgr 37
  • 57 (a)
Ef1beta 35
  • 58.67 (n)
  • 58.82 (a)
Ef1beta 36
  • 59 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010613 35
  • 60.33 (n)
  • 61.99 (a)
worm
(Caenorhabditis elegans)
Secernentea Y41E3.10 37
  • 65 (a)
eef-1B.1 35
  • 55.07 (n)
  • 53.14 (a)
eef-1B.1 36
  • 52 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR003C 35
  • 50.16 (n)
  • 49.03 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C18469g 35
  • 53.14 (n)
  • 50.72 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EFB1 35
  • 52.36 (n)
  • 51.22 (a)
EFB1 36
  • 50 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G19510 35
  • 52.7 (n)
  • 51.43 (a)
rice
(Oryza sativa)
Liliopsida Os07g0662500 35
  • 53.46 (n)
  • 49.06 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06035 35
  • 57.59 (n)
  • 58.48 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tef5 35
  • 58.53 (n)
  • 58.22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11115 36
  • 67 (a)
OneToOne
Species with no ortholog for EEF1B2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EEF1B2 Gene

ENSEMBL:
Gene Tree for EEF1B2 (if available)
TreeFam:
Gene Tree for EEF1B2 (if available)

Paralogs for EEF1B2 Gene

Paralogs for EEF1B2 Gene

(3) SIMAP similar genes for EEF1B2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with EEF1B2: view

Variants for EEF1B2 Gene

Sequence variations from dbSNP and Humsavar for EEF1B2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs3770985 -- 206,163,302(-) GCAGT(C/T)GCACA downstream-variant-500B
rs3770986 -- 206,163,197(-) tccag(A/C)taatt downstream-variant-500B
rs10207084 -- 206,163,061(+) TGCAG(C/T)GCAgg downstream-variant-500B
rs34451626 -- 206,163,097(+) ATCCC(A/G)GCAGT downstream-variant-500B
rs35819502 -- 206,163,180(+) TCTAC(-/A)AAAAA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for EEF1B2 Gene

Variant ID Type Subtype PubMed ID
nsv875737 CNV Gain 21882294
nsv821885 CNV Gain 20364138

Variation tolerance for EEF1B2 Gene

Residual Variation Intolerance Score: 27.64% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.65; 45.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EEF1B2 Gene

HapMap Linkage Disequilibrium report
EEF1B2
Human Gene Mutation Database (HGMD)
EEF1B2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EEF1B2 Gene

Disorders for EEF1B2 Gene

Relevant External Links for EEF1B2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EEF1B2
genes like me logo Genes that share disorders with EEF1B2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EEF1B2 Gene

Publications for EEF1B2 Gene

  1. Elongation factors are involved in cytokinesis of sea urchin eggs. (PMID: 20059555) Fujimoto H. … Mabuchi I. (Genes Cells 2010) 23 67
  2. Monitoring the regulation of gene expression in a growing organ using a fluid mechanics formalism. (PMID: 20202192) Merret R. … Bogeat-Triboulot M.B. (BMC Biol. 2010) 23 67
  3. Quantitative analysis of auxin-regulated proteins from basal part of leaf sheaths in rice by two-dimensional difference gel electrophoresis. (PMID: 18022655) Shi F. … Komatsu S. (Phytochemistry 2008) 23 67
  4. Proteomics analysis of differential expression of cellular proteins in response to avian H9N2 virus infection in human cells. (PMID: 18398875) Liu N. … Cai Z. (Proteomics 2008) 23 67
  5. Identification and characterization of a gibberellin-regulated protein, which is ASR5, in the basal region of rice leaf sheaths. (PMID: 18210155) Takasaki H. … Komatsu S. (Mol. Genet. Genomics 2008) 23 67

Products for EEF1B2 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate EEF1B2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for EEF1B2
    • Block miRNA regulation of EEF1B2 using miScript Target Protectors

    Sources for EEF1B2 Gene

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