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Aliases for EEF1B2 Gene

Aliases for EEF1B2 Gene

  • Eukaryotic Translation Elongation Factor 1 Beta 2 2 3 5
  • EF-1-Beta 3 4
  • EEF1B 3 4
  • EF1B 3 4
  • Eukaryotic Translation Elongation Factor 1 Beta 1 3
  • EEF1B1 3

External Ids for EEF1B2 Gene

Previous GeneCards Identifiers for EEF1B2 Gene

  • GC02P205241
  • GC02P205748
  • GC02P206988
  • GC02P207227
  • GC02P207228
  • GC02P206849
  • GC02P206732
  • GC02P207024

Summaries for EEF1B2 Gene

Entrez Gene Summary for EEF1B2 Gene

  • This gene encodes a translation elongation factor. The protein is a guanine nucleotide exchange factor involved in the transfer of aminoacylated tRNAs to the ribosome. Alternative splicing results in three transcript variants which differ only in the 5' UTR. [provided by RefSeq, Jul 2008]

GeneCards Summary for EEF1B2 Gene

EEF1B2 (Eukaryotic Translation Elongation Factor 1 Beta 2) is a Protein Coding gene. Among its related pathways are Gene Expression and Viral mRNA Translation. GO annotations related to this gene include translation elongation factor activity. An important paralog of this gene is EEF1D.

UniProtKB/Swiss-Prot for EEF1B2 Gene

  • EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.

Gene Wiki entry for EEF1B2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EEF1B2 Gene

Genomics for EEF1B2 Gene

Regulatory Elements for EEF1B2 Gene

Enhancers for EEF1B2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around EEF1B2 on UCSC Golden Path with GeneCards custom track

Promoters for EEF1B2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EEF1B2 on UCSC Golden Path with GeneCards custom track

Genomic Location for EEF1B2 Gene

Chromosome:
2
Start:
206,159,585 bp from pter
End:
206,162,929 bp from pter
Size:
3,345 bases
Orientation:
Plus strand

Genomic View for EEF1B2 Gene

Genes around EEF1B2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EEF1B2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EEF1B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EEF1B2 Gene

Proteins for EEF1B2 Gene

  • Protein details for EEF1B2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24534-EF1B_HUMAN
    Recommended name:
    Elongation factor 1-beta
    Protein Accession:
    P24534
    Secondary Accessions:
    • A8K795
    • Q6IBH9

    Protein attributes for EEF1B2 Gene

    Size:
    225 amino acids
    Molecular mass:
    24764 Da
    Quaternary structure:
    • EF-1 is composed of 4 subunits: alpha, beta, delta, and gamma.

    Three dimensional structures from OCA and Proteopedia for EEF1B2 Gene

neXtProt entry for EEF1B2 Gene

Proteomics data for EEF1B2 Gene at MOPED

Post-translational modifications for EEF1B2 Gene

  • Phosphorylation affects the GDP/GTP exchange rate.
  • Ubiquitination at Lys 78 and Lys 147
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for EEF1B2 Gene

Domains & Families for EEF1B2 Gene

Suggested Antigen Peptide Sequences for EEF1B2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P24534

UniProtKB/Swiss-Prot:

EF1B_HUMAN :
  • Contains 1 GST C-terminal domain.
  • Belongs to the EF-1-beta/EF-1-delta family.
Domain:
  • Contains 1 GST C-terminal domain.
Family:
  • Belongs to the EF-1-beta/EF-1-delta family.
genes like me logo Genes that share domains with EEF1B2: view

No data available for Gene Families for EEF1B2 Gene

Function for EEF1B2 Gene

Molecular function for EEF1B2 Gene

GENATLAS Biochemistry:
eukaryotic translation elongation factor 1,beta 2,specifically transcribed in fetal brain and in skeletal muscle (multigene family)
UniProtKB/Swiss-Prot Function:
EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.
UniProtKB/Swiss-Prot Induction:
By homocysteine (HC), may mediate accelerated synthesis of free thiol-containing proteins in response to HC-induced oxidative stress.

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EEF1B2 Gene

Localization for EEF1B2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EEF1B2 Gene COMPARTMENTS Subcellular localization image for EEF1B2 gene
Compartment Confidence
cytosol 5
nucleus 3
cytoskeleton 1
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for EEF1B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005853 eukaryotic translation elongation factor 1 complex IEA,NAS 1886777
genes like me logo Genes that share ontologies with EEF1B2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for EEF1B2 Gene

Pathways & Interactions for EEF1B2 Gene

genes like me logo Genes that share pathways with EEF1B2: view

Pathways by source for EEF1B2 Gene

1 BioSystems pathway for EEF1B2 Gene

Gene Ontology (GO) - Biological Process for EEF1B2 Gene

None

No data available for SIGNOR curated interactions for EEF1B2 Gene

Drugs & Compounds for EEF1B2 Gene

(1) Drugs for EEF1B2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(4) Additional Compounds for EEF1B2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with EEF1B2: view

Transcripts for EEF1B2 Gene

Unigene Clusters for EEF1B2 Gene

Eukaryotic translation elongation factor 1 beta 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EEF1B2 Gene

No ASD Table

Relevant External Links for EEF1B2 Gene

GeneLoc Exon Structure for
EEF1B2
ECgene alternative splicing isoforms for
EEF1B2

Expression for EEF1B2 Gene

mRNA expression in normal human tissues for EEF1B2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EEF1B2 Gene



SOURCE GeneReport for Unigene cluster for EEF1B2 Gene Hs.421608

genes like me logo Genes that share expression patterns with EEF1B2: view

Protein tissue co-expression partners for EEF1B2 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EEF1B2 Gene

Orthologs for EEF1B2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EEF1B2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EEF1B2 35
  • 91.11 (n)
  • 97.78 (a)
EEF1B 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EEF1B2 35
  • 93.04 (n)
  • 98.22 (a)
-- 36
  • 74 (a)
OneToMany
-- 36
  • 92 (a)
OneToMany
-- 36
  • 76 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Eef1b2 35
  • 89.19 (n)
  • 95.56 (a)
Eef1b2 16
Eef1b2 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EEF1B2 35
  • 99.85 (n)
  • 100 (a)
EEF1B2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eef1b2 35
  • 89.19 (n)
  • 94.67 (a)
oppossum
(Monodelphis domestica)
Mammalia EEF1B2 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EEF1B2 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves EEF1B2 35
  • 81.99 (n)
  • 93.3 (a)
EEF1B2 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EEF1B2 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eef1b2 35
  • 78.07 (n)
  • 85.33 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.20382 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
eef1b2 35
  • 73.81 (n)
  • 82.59 (a)
eef1b2 36
  • 79 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Ef1bgr 37
  • 57 (a)
Ef1beta 35
  • 58.67 (n)
  • 58.82 (a)
Ef1beta 36
  • 59 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010613 35
  • 60.33 (n)
  • 61.99 (a)
worm
(Caenorhabditis elegans)
Secernentea Y41E3.10 37
  • 65 (a)
eef-1B.1 35
  • 55.07 (n)
  • 53.14 (a)
eef-1B.1 36
  • 52 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR003C 35
  • 50.16 (n)
  • 49.03 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C18469g 35
  • 53.14 (n)
  • 50.72 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EFB1 35
  • 52.36 (n)
  • 51.22 (a)
EFB1 36
  • 50 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G19510 35
  • 52.7 (n)
  • 51.43 (a)
rice
(Oryza sativa)
Liliopsida Os07g0662500 35
  • 53.46 (n)
  • 49.06 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06035 35
  • 57.59 (n)
  • 58.48 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tef5 35
  • 58.53 (n)
  • 58.22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11115 36
  • 67 (a)
OneToOne
Species with no ortholog for EEF1B2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EEF1B2 Gene

ENSEMBL:
Gene Tree for EEF1B2 (if available)
TreeFam:
Gene Tree for EEF1B2 (if available)

Paralogs for EEF1B2 Gene

Paralogs for EEF1B2 Gene

(3) SIMAP similar genes for EEF1B2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with EEF1B2: view

Variants for EEF1B2 Gene

Sequence variations from dbSNP and Humsavar for EEF1B2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs3770985 -- 206,163,302(-) GCAGT(C/T)GCACA downstream-variant-500B
rs3770986 -- 206,163,197(-) tccag(A/C)taatt downstream-variant-500B
rs10207084 -- 206,163,061(+) TGCAG(C/T)GCAgg downstream-variant-500B
rs34451626 -- 206,163,097(+) ATCCC(A/G)GCAGT downstream-variant-500B
rs35819502 -- 206,163,180(+) TCTAC(-/A)AAAAA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for EEF1B2 Gene

Variant ID Type Subtype PubMed ID
nsv875737 CNV Gain 21882294
nsv821885 CNV Gain 20364138

Variation tolerance for EEF1B2 Gene

Residual Variation Intolerance Score: 27.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.65; 45.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EEF1B2 Gene

Human Gene Mutation Database (HGMD)
EEF1B2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EEF1B2 Gene

Disorders for EEF1B2 Gene

Relevant External Links for EEF1B2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EEF1B2

No disorders were found for EEF1B2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EEF1B2 Gene

Publications for EEF1B2 Gene

  1. Human elongation factor 1 beta: cDNA and derived amino acid sequence. (PMID: 1710449) von der Kammer H. … Scheit K.H. (Biochem. Biophys. Res. Commun. 1991) 3 4 23 67
  2. Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm. (PMID: 12426392) Bohnsack M.T. … Goerlich D. (EMBO J. 2002) 3 23
  3. The solution structure of the guanine nucleotide exchange domain of human elongation factor 1beta reveals a striking resemblance to that of EF-Ts from Escherichia coli. (PMID: 10368288) PAcrez J.M. … MAPller W. (Structure 1999) 3 23
  4. Human lymphocyte cDNA ordered library analyzed by 2D gel electrophoresis. 3. Analysis of individual clones. (PMID: 8573604) BAchar G. … Lefkovits I. (Appl. Theor. Electrophor. 1995) 3 23
  5. Human elongation factor EF-1 beta: cloning and characterization of the EF1 beta 5a gene and assignment of EF-1 beta isoforms to chromosomes 2,5,15 and X. (PMID: 8250921) Pizzuti A. … Dallapiccola B. (Biochem. Biophys. Res. Commun. 1993) 2 3

Products for EEF1B2 Gene

Sources for EEF1B2 Gene

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