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Aliases for EEF1AKMT3 Gene

Aliases for EEF1AKMT3 Gene

  • EEF1A Lysine Methyltransferase 3 2 3
  • Methyltransferase Like 21B 2 3 5
  • METTL21B 3 4 5
  • Hepatocellular Carcinoma-Associated Antigen 557a 3 4
  • Family With Sequence Similarity 119, Member B 2 3
  • Methyltransferase-Like Protein 21B 3 4
  • FAM119B 3 4
  • Hepatocellularcarcinoma-Associated Antigen HCA557a 3
  • Protein-Lysine Methyltransferase METTL21B 3
  • EC 2.1.1.- 4
  • HCA557A 4

External Ids for EEF1AKMT3 Gene

Previous HGNC Symbols for EEF1AKMT3 Gene

  • FAM119B
  • METTL21B

Summaries for EEF1AKMT3 Gene

GeneCards Summary for EEF1AKMT3 Gene

EEF1AKMT3 (EEF1A Lysine Methyltransferase 3) is a Protein Coding gene. An important paralog of this gene is METTL21A.

UniProtKB/Swiss-Prot for EEF1AKMT3 Gene

  • Protein-lysine methyltransferase.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EEF1AKMT3 Gene

Genomics for EEF1AKMT3 Gene

Regulatory Elements for EEF1AKMT3 Gene

Enhancers for EEF1AKMT3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G057830 2 FANTOM5 Ensembl ENCODE dbSUPER 35.4 +68.0 67988 17.0 MLX FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC ZNF610 GLIS1 EEF1AKMT3 TSFM ATP23 METTL1 CTDSP2 TSPAN31 CDK4 AGAP2 LOC283387 PIR34053
GH12G057863 1.8 FANTOM5 Ensembl ENCODE dbSUPER 33.6 +93.4 93427 2.6 ATF1 SIN3A GLIS2 FOS DEK SP3 REST SMARCB1 SMARCA4 GLIS1 EEF1AKMT3 MIR26A2 CDK4 AVIL RNU6-1083P TSFM METTL1 CYP27B1 MARCH9 CTDSP2
GH12G057770 1.1 ENCODE 50 +0.6 636 3.0 HDGF MLX CREB3L1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 TSFM EEF1AKMT3 METTL1
GH12G057868 1.4 FANTOM5 Ensembl ENCODE dbSUPER 33.6 +97.9 97875 2.0 PKNOX1 POLR2A SMARCA4 SCRT2 KLF17 FOXP2 ZBTB8A EEF1AKMT3 AVIL CTDSP2 MIR26A2 TSFM METTL1 CYP27B1 RNU6-1083P CDK4 MARCH9
GH12G057886 1.9 FANTOM5 Ensembl ENCODE dbSUPER 23.7 +121.8 121804 13.7 HDGF PKNOX1 FOXA2 ZNF2 ZNF143 FOS SP3 JUNB REST TBX21 ATP23 EEF1AKMT3 CTDSP2 TSFM MIR26A2 AVIL RNU6-1083P MARCH9 LOC283387 GLI1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EEF1AKMT3 on UCSC Golden Path with GeneCards custom track

Promoters for EEF1AKMT3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000052703 1008 2201 HDGF MLX CREB3L1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for EEF1AKMT3 Gene

Chromosome:
12
Start:
57,771,492 bp from pter
End:
57,782,541 bp from pter
Size:
11,050 bases
Orientation:
Plus strand

Genomic View for EEF1AKMT3 Gene

Genes around EEF1AKMT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EEF1AKMT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EEF1AKMT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EEF1AKMT3 Gene

Proteins for EEF1AKMT3 Gene

  • Protein details for EEF1AKMT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96AZ1-MT21B_HUMAN
    Recommended name:
    Protein-lysine methyltransferase METTL21B
    Protein Accession:
    Q96AZ1
    Secondary Accessions:
    • Q9H749
    • Q9Y3W2

    Protein attributes for EEF1AKMT3 Gene

    Size:
    226 amino acids
    Molecular mass:
    24911 Da
    Quaternary structure:
    • Interacts with members of the heat shock protein 70 and 90 families and of the TCP-1 chaperonin family, as well as with HSPD1, STIP1 and tubulin; at least some of these proteins may be methylation substrates.

    Three dimensional structures from OCA and Proteopedia for EEF1AKMT3 Gene

    Alternative splice isoforms for EEF1AKMT3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EEF1AKMT3 Gene

Post-translational modifications for EEF1AKMT3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EEF1AKMT3 Gene

No data available for DME Specific Peptides for EEF1AKMT3 Gene

Domains & Families for EEF1AKMT3 Gene

Gene Families for EEF1AKMT3 Gene

Protein Domains for EEF1AKMT3 Gene

Suggested Antigen Peptide Sequences for EEF1AKMT3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96AZ1

UniProtKB/Swiss-Prot:

MT21B_HUMAN :
  • Belongs to the methyltransferase superfamily. METTL21 family.
Family:
  • Belongs to the methyltransferase superfamily. METTL21 family.
genes like me logo Genes that share domains with EEF1AKMT3: view

Function for EEF1AKMT3 Gene

Molecular function for EEF1AKMT3 Gene

UniProtKB/Swiss-Prot Function:
Protein-lysine methyltransferase.

Enzyme Numbers (IUBMB) for EEF1AKMT3 Gene

Gene Ontology (GO) - Molecular Function for EEF1AKMT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IEA,IDA 28108655
GO:0016279 protein-lysine N-methyltransferase activity IDA 28108655
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with EEF1AKMT3: view
genes like me logo Genes that share phenotypes with EEF1AKMT3: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for EEF1AKMT3 Gene

Localization for EEF1AKMT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EEF1AKMT3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EEF1AKMT3 gene
Compartment Confidence
cytoskeleton 5
nucleus 3
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for EEF1AKMT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005737 cytoplasm IDA,IEA 28108655
GO:0005813 centrosome IDA 28108655
genes like me logo Genes that share ontologies with EEF1AKMT3: view

Pathways & Interactions for EEF1AKMT3 Gene

SuperPathways for EEF1AKMT3 Gene

No Data Available

Interacting Proteins for EEF1AKMT3 Gene

Gene Ontology (GO) - Biological Process for EEF1AKMT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018022 peptidyl-lysine methylation IDA 28108655
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with EEF1AKMT3: view

No data available for Pathways by source and SIGNOR curated interactions for EEF1AKMT3 Gene

Drugs & Compounds for EEF1AKMT3 Gene

No Compound Related Data Available

Transcripts for EEF1AKMT3 Gene

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EEF1AKMT3 Gene

No ASD Table

Relevant External Links for EEF1AKMT3 Gene

GeneLoc Exon Structure for
EEF1AKMT3
ECgene alternative splicing isoforms for
EEF1AKMT3

Expression for EEF1AKMT3 Gene

NURSA nuclear receptor signaling pathways regulating expression of EEF1AKMT3 Gene:

EEF1AKMT3

Evidence on tissue expression from TISSUES for EEF1AKMT3 Gene

  • Intestine(4.2)
  • Lung(4.2)
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EEF1AKMT3 Gene

Orthologs for EEF1AKMT3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EEF1AKMT3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia METTL21B 34 35
  • 99.41 (n)
dog
(Canis familiaris)
Mammalia METTL21B 35 34
  • 93 (n)
OneToOne
cow
(Bos Taurus)
Mammalia METTL21B 35 34
  • 92.04 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC679247 34
  • 86.64 (n)
mouse
(Mus musculus)
Mammalia LOC100504608 34
  • 86.28 (n)
Mettl21b 35
  • 83 (a)
OneToOne
Eef1akmt3 16
oppossum
(Monodelphis domestica)
Mammalia METTL21B 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia METTL21B 35
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 30 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia METTL21B 35
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl21b 34
  • 61.62 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:92518 35
  • 34 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea C42C1.13 35
  • 32 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 35
  • 28 (a)
OneToMany
EFM2 37
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 32 (a)
OneToMany
Species where no ortholog for EEF1AKMT3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EEF1AKMT3 Gene

ENSEMBL:
Gene Tree for EEF1AKMT3 (if available)
TreeFam:
Gene Tree for EEF1AKMT3 (if available)

Paralogs for EEF1AKMT3 Gene

Paralogs for EEF1AKMT3 Gene

genes like me logo Genes that share paralogs with EEF1AKMT3: view

Variants for EEF1AKMT3 Gene

Sequence variations from dbSNP and Humsavar for EEF1AKMT3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs587777689 Pathogenic 57,782,862(+) CGGTG(A/G)GAAGT intron-variant, downstream-variant-500B
rs869025542 Uncertain significance 57,782,803(+) AGAGA(G/T)GTCGC downstream-variant-500B, reference, missense
rs10747783 Benign 57,782,831(+) GTGTT(C/T)CTGGT downstream-variant-500B, reference, synonymous-codon
rs138461986 Benign 57,782,825(+) CTGCG(C/T)GTGTT downstream-variant-500B, reference, synonymous-codon
rs1000322606 -- 57,775,910(+) CCTAA(A/C)AATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EEF1AKMT3 Gene

Variant ID Type Subtype PubMed ID
nsv470296 CNV loss 18288195
nsv470297 CNV gain 18288195
nsv510601 CNV deletion 20534489
nsv559046 CNV gain 21841781

Variation tolerance for EEF1AKMT3 Gene

Residual Variation Intolerance Score: 49.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.29; 25.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EEF1AKMT3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EEF1AKMT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EEF1AKMT3 Gene

Disorders for EEF1AKMT3 Gene

Relevant External Links for EEF1AKMT3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EEF1AKMT3

No disorders were found for EEF1AKMT3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EEF1AKMT3 Gene

Publications for EEF1AKMT3 Gene

  1. The novel lysine specific methyltransferase METTL21B affects mRNA translation through inducible and dynamic methylation of Lys-165 in human eukaryotic elongation factor 1 alpha (eEF1A). (PMID: 28108655) MaA8ecki J. … Falnes P.A.9. (Nucleic Acids Res. 2017) 2 3 64
  2. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PMID: 23349634) Cloutier P. … Coulombe B. (PLoS Genet. 2013) 3 4 64
  3. Lysine methylation of VCP by a member of a novel human protein methyltransferase family. (PMID: 22948820) Kernstock S. … Falnes P.O. (Nat. Commun. 2012) 3 64
  4. The multiple sclerosis whole blood mRNA transcriptome and genetic associations indicate dysregulation of specific T cell pathways in pathogenesis. (PMID: 20190274) Gandhi K.S. … Booth D.R. (Hum. Mol. Genet. 2010) 3 64
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3 64

Products for EEF1AKMT3 Gene

Sources for EEF1AKMT3 Gene

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