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Aliases for EEF1AKMT2 Gene

Aliases for EEF1AKMT2 Gene

  • EEF1A Lysine Methyltransferase 2 2 3
  • Methyltransferase Like 10 2 3 5
  • METTL10 3 4 5
  • Eukaryotic Translation Elongation Factor 1 Alpha Lysine Methyltransferase 2 2 3
  • Methyltransferase-Like Protein 10 3 4
  • C10orf138 3 4
  • Protein-Lysine N-Methyltransferase METTL10 3
  • Chromosome 10 Open Reading Frame 138 2
  • EC 2.1.1.- 4
  • EC 2.1.1 61
  • Efm4 3

External Ids for EEF1AKMT2 Gene

Previous HGNC Symbols for EEF1AKMT2 Gene

  • C10orf138
  • METTL10

Summaries for EEF1AKMT2 Gene

GeneCards Summary for EEF1AKMT2 Gene

EEF1AKMT2 (EEF1A Lysine Methyltransferase 2) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Protein methylation. An important paralog of this gene is ENSG00000258539.

UniProtKB/Swiss-Prot for EEF1AKMT2 Gene

  • S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EEF1AKMT2 Gene

Genomics for EEF1AKMT2 Gene

Regulatory Elements for EEF1AKMT2 Gene

Enhancers for EEF1AKMT2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G124731 1.9 FANTOM5 Ensembl ENCODE dbSUPER 58.2 +51.5 51508 18.4 PKNOX1 FOXA2 ARNT AGO1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 EEF1AKMT2 FAM53B ABRAXAS2 ENSG00000234134 GC10P124736
GH10G124714 2 FANTOM5 Ensembl ENCODE dbSUPER 46.4 +69.1 69144 16.1 HDGF PKNOX1 MLX ARNT WRNIP1 SIN3A ZNF766 ZNF143 ZNF207 FOS EEF1AKMT2 FAM53B ABRAXAS2 ZRANB1 GC10P124712 GC10P124736
GH10G124691 2 FANTOM5 Ensembl ENCODE dbSUPER 30.2 +90.5 90535 19.6 HDGF ARNT WRNIP1 ARID4B SIN3A ZNF2 ZNF766 FOS ZNF263 TBX21 EEF1AKMT2 FAM53B LHPP ZRANB1 FAM53B-AS1 GC10M124645 PIR48648
GH10G124790 1.1 ENCODE 38.1 +0.1 68 2.6 HNRNPUL1 FOXA2 MLX CREB3L1 ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF207 EEF1AKMT2 EDRF1-AS1 MMP21 ENSG00000258539
GH10G124682 1.8 FANTOM5 Ensembl ENCODE dbSUPER 22.9 +105.3 105250 8.1 PKNOX1 SIN3A ZNF766 FOS JUNB TBX21 ZNF592 CREB3 SMARCA4 PBX2 EEF1AKMT2 FAM53B LHPP ZRANB1 FAM53B-AS1 GC10M124645 PIR48648
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EEF1AKMT2 on UCSC Golden Path with GeneCards custom track

Promoters for EEF1AKMT2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000034849 141 2401 HNRNPUL1 MLX CREB3L1 ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF207 ZNF143

Genomic Location for EEF1AKMT2 Gene

Chromosome:
10
Start:
124,748,149 bp from pter
End:
124,791,941 bp from pter
Size:
43,793 bases
Orientation:
Minus strand

Genomic View for EEF1AKMT2 Gene

Genes around EEF1AKMT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EEF1AKMT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EEF1AKMT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EEF1AKMT2 Gene

Proteins for EEF1AKMT2 Gene

  • Protein details for EEF1AKMT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JPI9-MET10_HUMAN
    Recommended name:
    Protein-lysine N-methyltransferase METTL10
    Protein Accession:
    Q5JPI9
    Secondary Accessions:
    • A8MPY7

    Protein attributes for EEF1AKMT2 Gene

    Size:
    291 amino acids
    Molecular mass:
    31830 Da
    Quaternary structure:
    No Data Available

neXtProt entry for EEF1AKMT2 Gene

Selected DME Specific Peptides for EEF1AKMT2 Gene

Q5JPI9:
  • EFVKRII
  • QGRTMRWALAWSFY
  • IHDSLQLKKRLRWYSCMLGKKCSLAPLK
  • FLATEVDD
  • DLMNQLCT
  • ILTDLKV
  • RNRYKDKPPDF
  • LIKVVKVPQKTLLMDALKEES
  • RKLEKPRKP
  • FCMCNPPFF
  • TEIMAEGGELEFVKR

Post-translational modifications for EEF1AKMT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EEF1AKMT2 Gene

Domains & Families for EEF1AKMT2 Gene

Gene Families for EEF1AKMT2 Gene

Protein Domains for EEF1AKMT2 Gene

Suggested Antigen Peptide Sequences for EEF1AKMT2 Gene

Graphical View of Domain Structure for InterPro Entry

Q5JPI9

UniProtKB/Swiss-Prot:

MET10_HUMAN :
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.
genes like me logo Genes that share domains with EEF1AKMT2: view

Function for EEF1AKMT2 Gene

Molecular function for EEF1AKMT2 Gene

UniProtKB/Swiss-Prot Function:
S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.

Enzyme Numbers (IUBMB) for EEF1AKMT2 Gene

Gene Ontology (GO) - Molecular Function for EEF1AKMT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IEA,IDA 25144183
GO:0016279 protein-lysine N-methyltransferase activity TAS --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with EEF1AKMT2: view
genes like me logo Genes that share phenotypes with EEF1AKMT2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EEF1AKMT2 Gene

Localization for EEF1AKMT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EEF1AKMT2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EEF1AKMT2 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 1
mitochondrion 1
lysosome 1

Gene Ontology (GO) - Cellular Components for EEF1AKMT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 25144183
GO:0005737 cytoplasm IDA 25144183
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with EEF1AKMT2: view

Pathways & Interactions for EEF1AKMT2 Gene

genes like me logo Genes that share pathways with EEF1AKMT2: view

Pathways by source for EEF1AKMT2 Gene

Interacting Proteins for EEF1AKMT2 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000357829%0d%0a9606.ENSP00000298910%0d%0a9606.ENSP00000373600%0d%0a9606.ENSP00000357040%0d%0a9606.ENSP00000310800%0d%0a9606.ENSP00000330054%0d%0a
Selected Interacting proteins: ENSP00000357829 Q5JPI9-MET10_HUMAN for EEF1AKMT2 Gene via STRING IID

Gene Ontology (GO) - Biological Process for EEF1AKMT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006479 protein methylation TAS --
GO:0018022 peptidyl-lysine methylation IEA,IDA 25144183
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with EEF1AKMT2: view

No data available for SIGNOR curated interactions for EEF1AKMT2 Gene

Drugs & Compounds for EEF1AKMT2 Gene

No Compound Related Data Available

Transcripts for EEF1AKMT2 Gene

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EEF1AKMT2 Gene

No ASD Table

Relevant External Links for EEF1AKMT2 Gene

GeneLoc Exon Structure for
EEF1AKMT2
ECgene alternative splicing isoforms for
EEF1AKMT2

Expression for EEF1AKMT2 Gene

NURSA nuclear receptor signaling pathways regulating expression of EEF1AKMT2 Gene:

EEF1AKMT2

Evidence on tissue expression from TISSUES for EEF1AKMT2 Gene

  • Lymph node(4.2)
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EEF1AKMT2 Gene

Orthologs for EEF1AKMT2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EEF1AKMT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia METTL10 34 35
  • 99.77 (n)
rat
(Rattus norvegicus)
Mammalia Mettl10 34
  • 89.58 (n)
mouse
(Mus musculus)
Mammalia Mettl10 34
  • 88.89 (n)
Eef1akmt2 16
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 68 (a)
OneToMany
chicken
(Gallus gallus)
Aves METTL10 34
  • 75.89 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 67 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498530 34
  • 62.27 (n)
zebrafish
(Danio rerio)
Actinopterygii mettl10 34 35
  • 62.19 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005673 34
  • 53.14 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9643 34 35
  • 52.57 (n)
worm
(Caenorhabditis elegans)
Secernentea F29B9.1 34 35
  • 49.25 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEE1 34 35
  • 50.29 (n)
EFM4 37
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C07931g 34
  • 49.9 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AR401 34
  • 52.54 (n)
rice
(Oryza sativa)
Liliopsida Os01g0121100 34
  • 53.85 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC839.14c 34
  • 50 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 35 (a)
OneToMany
Species where no ortholog for EEF1AKMT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EEF1AKMT2 Gene

ENSEMBL:
Gene Tree for EEF1AKMT2 (if available)
TreeFam:
Gene Tree for EEF1AKMT2 (if available)

Paralogs for EEF1AKMT2 Gene

Paralogs for EEF1AKMT2 Gene

genes like me logo Genes that share paralogs with EEF1AKMT2: view

Variants for EEF1AKMT2 Gene

Sequence variations from dbSNP and Humsavar for EEF1AKMT2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000076263 -- 124,779,541(+) GGAGA(A/T)CGAGA intron-variant
rs1000125071 -- 124,779,285(+) CACCA(C/T)GACAC intron-variant
rs1000140343 -- 124,787,341(+) GGCAC(A/G)AGAAC intron-variant
rs1000150604 -- 124,778,197(+) ATACA(C/T)ACACA intron-variant
rs1000203396 -- 124,778,492(+) GCCAA(A/G)GCAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EEF1AKMT2 Gene

Variant ID Type Subtype PubMed ID
esv3624817 CNV loss 21293372
nsv1050837 CNV gain 25217958
nsv1051396 CNV loss 25217958
nsv825604 CNV gain 20364138
nsv832013 CNV loss 17160897
nsv832014 CNV loss 17160897

Variation tolerance for EEF1AKMT2 Gene

Residual Variation Intolerance Score: 76.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.75; 57.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EEF1AKMT2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EEF1AKMT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EEF1AKMT2 Gene

Disorders for EEF1AKMT2 Gene

Relevant External Links for EEF1AKMT2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EEF1AKMT2

No disorders were found for EEF1AKMT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EEF1AKMT2 Gene

Publications for EEF1AKMT2 Gene

  1. Selenium-based S-adenosylmethionine analog reveals the mammalian seven-beta-strand methyltransferase METTL10 to be an EF1A1 lysine methyltransferase. (PMID: 25144183) Shimazu T. … Shinkai Y. (PLoS ONE 2014) 2 3 64
  2. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  3. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3 64
  4. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P. … Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012) 4 64
  5. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PMID: 19413330) Gauci S. … Mohammed S. (Anal. Chem. 2009) 4 64

Products for EEF1AKMT2 Gene

Sources for EEF1AKMT2 Gene

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