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Aliases for EEF1AKMT1 Gene

Aliases for EEF1AKMT1 Gene

  • Eukaryotic Translation Elongation Factor 1 Alpha Lysine Methyltransferase 1 2 3
  • N-6 Adenine-Specific DNA Methyltransferase 2 (Putative) 2 3 5
  • N6AMT2 3 4 5
  • N(6)-Adenine-Specific DNA Methyltransferase 2 3 4
  • EC 2.1.1.- 4
  • EC 2.1.1 63
  • ESP13 3

External Ids for EEF1AKMT1 Gene

Previous HGNC Symbols for EEF1AKMT1 Gene

  • N6AMT2

Summaries for EEF1AKMT1 Gene

GeneCards Summary for EEF1AKMT1 Gene

EEF1AKMT1 (Eukaryotic Translation Elongation Factor 1 Alpha Lysine Methyltransferase 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for EEF1AKMT1 Gene

  • S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EEF1AKMT1 Gene

Genomics for EEF1AKMT1 Gene

Regulatory Elements for EEF1AKMT1 Gene

Enhancers for EEF1AKMT1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around EEF1AKMT1 on UCSC Golden Path with GeneCards custom track

Promoters for EEF1AKMT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EEF1AKMT1 on UCSC Golden Path with GeneCards custom track

Genomic Location for EEF1AKMT1 Gene

Chromosome:
13
Start:
20,728,731 bp from pter
End:
20,773,958 bp from pter
Size:
45,228 bases
Orientation:
Minus strand

Genomic View for EEF1AKMT1 Gene

Genes around EEF1AKMT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EEF1AKMT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EEF1AKMT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EEF1AKMT1 Gene

Proteins for EEF1AKMT1 Gene

  • Protein details for EEF1AKMT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WVE0-N6MT2_HUMAN
    Recommended name:
    Protein-lysine N-methyltransferase N6AMT2
    Protein Accession:
    Q8WVE0
    Secondary Accessions:
    • B5G4V1

    Protein attributes for EEF1AKMT1 Gene

    Size:
    214 amino acids
    Molecular mass:
    24506 Da
    Quaternary structure:
    No Data Available

neXtProt entry for EEF1AKMT1 Gene

Proteomics data for EEF1AKMT1 Gene at MOPED

Selected DME Specific Peptides for EEF1AKMT1 Gene

Post-translational modifications for EEF1AKMT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EEF1AKMT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for EEF1AKMT1 Gene

Protein Domains for EEF1AKMT1 Gene

Suggested Antigen Peptide Sequences for EEF1AKMT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WVE0

UniProtKB/Swiss-Prot:

N6MT2_HUMAN :
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.
genes like me logo Genes that share domains with EEF1AKMT1: view

No data available for Gene Families for EEF1AKMT1 Gene

Function for EEF1AKMT1 Gene

Molecular function for EEF1AKMT1 Gene

UniProtKB/Swiss-Prot Function:
S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.

Enzyme Numbers (IUBMB) for EEF1AKMT1 Gene

Gene Ontology (GO) - Molecular Function for EEF1AKMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with EEF1AKMT1: view
genes like me logo Genes that share phenotypes with EEF1AKMT1: view

Animal Models for EEF1AKMT1 Gene

MGI Knock Outs for EEF1AKMT1:

Animal Model Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for EEF1AKMT1 Gene

Localization for EEF1AKMT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EEF1AKMT1 Gene

Cytoplasm.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for EEF1AKMT1 Gene

Pathways & Interactions for EEF1AKMT1 Gene

SuperPathways for EEF1AKMT1 Gene

No Data Available

Interacting Proteins for EEF1AKMT1 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000372202%0d%0a9606.ENSP00000332643%0d%0a9606.ENSP00000304697%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000372202 Q8WVE0-N6MT2_HUMAN for EEF1AKMT1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for EEF1AKMT1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for EEF1AKMT1 Gene

Drugs & Compounds for EEF1AKMT1 Gene

No Compound Related Data Available

Transcripts for EEF1AKMT1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for EEF1AKMT1 Gene

No ASD Table

Relevant External Links for EEF1AKMT1 Gene

GeneLoc Exon Structure for
EEF1AKMT1
ECgene alternative splicing isoforms for
EEF1AKMT1

Expression for EEF1AKMT1 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for EEF1AKMT1 Gene

Orthologs for EEF1AKMT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EEF1AKMT1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia N6AMT2 35
  • 76.48 (n)
  • 74.77 (a)
N6AMT2 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia N6AMT2 35
  • 86.41 (n)
  • 84.36 (a)
N6AMT2 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia N6amt2 35
  • 80.82 (n)
  • 82.55 (a)
Eef1akmt1 16
N6amt2 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia N6AMT2 35
  • 99.38 (n)
  • 98.6 (a)
N6AMT2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia N6amt2 35
  • 80.97 (n)
  • 83.49 (a)
oppossum
(Monodelphis domestica)
Mammalia N6AMT2 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia N6AMT2 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves N6AMT2 35
  • 74 (n)
  • 72.73 (a)
N6AMT2 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia N6AMT2 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia n6amt2 35
  • 69.35 (n)
  • 66.82 (a)
Str.20519 35
zebrafish
(Danio rerio)
Actinopterygii n6amt2 35
  • 66.46 (n)
  • 68.32 (a)
n6amt2 36
  • 66 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5203 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010213 35
  • 52.24 (n)
  • 46.77 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9154 35
  • 51.99 (n)
  • 44.04 (a)
CG9154 36
  • 36 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_M142.8 35
  • 54.58 (n)
  • 49.51 (a)
M142.8 36
  • 44 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL001W 35
  • 51.56 (n)
  • 42.86 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A08712g 35
  • 50.32 (n)
  • 43.69 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YGR001C 35
  • 51.89 (n)
  • 44.33 (a)
-- 36
  • 36 (a)
OneToOne
EFM5 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G58470 35
  • 53.11 (n)
  • 45.45 (a)
rice
(Oryza sativa)
Liliopsida Os03g0749900 35
  • 48.09 (n)
  • 44.78 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02372 35
  • 50.25 (n)
  • 44.78 (a)
Species with no ortholog for EEF1AKMT1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EEF1AKMT1 Gene

ENSEMBL:
Gene Tree for EEF1AKMT1 (if available)
TreeFam:
Gene Tree for EEF1AKMT1 (if available)

Paralogs for EEF1AKMT1 Gene

No data available for Paralogs for EEF1AKMT1 Gene

Variants for EEF1AKMT1 Gene

Sequence variations from dbSNP and Humsavar for EEF1AKMT1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs944054 -- 20,738,627(-) ttgta(G/T)gggtg intron-variant
rs732414 -- 20,737,838(+) TTTTA(A/G)AACTG intron-variant
rs2480435 -- 20,748,113(-) TTAAG(A/G)GCAGG intron-variant
rs2243582 -- 20,731,014(+) aagaa(A/G)aaaca intron-variant
rs2248444 -- 20,753,587(-) tctga(G/T)gtata intron-variant

Variation tolerance for EEF1AKMT1 Gene

Residual Variation Intolerance Score: 39.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.56; 12.03% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for EEF1AKMT1 Gene

Disorders for EEF1AKMT1 Gene

Relevant External Links for EEF1AKMT1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EEF1AKMT1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EEF1AKMT1

No disorders were found for EEF1AKMT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EEF1AKMT1 Gene

Publications for EEF1AKMT1 Gene

  1. Novel N-terminal and Lysine Methyltransferases That Target Translation Elongation Factor 1A in Yeast and Human. (PMID: 26545399) Hamey J.J. … Wilkins M.R. (Mol. Cell Proteomics 2016) 2 3 67
  2. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3
  3. Genetic determinants of P wave duration and PR segment. (PMID: 24850809) Verweij N. … van der Harst P. (Circ Cardiovasc Genet 2014) 3
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  5. Transcriptome analysis of a cDNA library from adult human epididymis. (PMID: 18390568) Li J.Y. … Zhang Y.L. (DNA Res. 2008) 3

Products for EEF1AKMT1 Gene

Sources for EEF1AKMT1 Gene

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