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Aliases & Descriptions for EEF1A2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| EEF1AL 1, 2, 3 | | EF-1-alpha-2 2, 3 | | EF1A 2 | | FLJ41696 2 | | HS1 1, 2 | | OTTHUMP00000031776 2 | | STN 1, 2, 3 | | STNL 2 | | eEF1A-2 3 | | statin-like 1, 2 |
| | | Descriptions |
|---|
| Elongation factor 1 A-2 3 | | Statin S1 2, 3 | | elongation factor 1-alpha 2 2 | | elongation factor-1 alpha 2 | | eukaryotic translation elongation factor 1 alpha 2 2 |
|
| | Search outside databases for aliases for EEF1A2 genePrevious GC identifers: GC20M061996 GC20M062798 GC20M062845 |
Summaries for EEF1A2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for EEF1A2: This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 2) is expressed in brain, heart and skeletal muscle, and the other isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas. This gene may be critical in the development of ovarian cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] UniProtKB/Swiss-Prot: EF1A2_HUMAN, Q05639Function: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesisGene Wiki entry for EEF1A2 |
Genomic Location for EEF1A2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the EEF1A2 gene 
Entrez Gene cytogenetic band: 20q13.3 Ensembl cytogenetic band: 20q13.33 HGNC cytogenetic band: 20q13.3EEF1A2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M061589:
(about GC identifiers)
Start:
|
61,589,810 bp from pter |
End:
|
61,601,081 bp from pter |
Size:
|
11,272 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000020.9 NT_011333.5
| Proteins for EEF1A2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: EF1A2_HUMAN, Q05639 (See
protein sequence)Recommended Name: Elongation factor 1-alpha 2 Size: 463 amino acids; 50470 Da
Subunit: Monomer (By similarity)
Subcellular location: Nucleus (By similarity)
PDB structures from and Proteopedia :3C5J (3D)
 
Secondary accessions: B5BUF3 P54266 Q0VGC7Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_001949.1
ENSEMBL proteins: ENSP00000298049 ENSP00000217182
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- | | GO:0005737 | cytoplasm |
IEA | -- | | GO:0005853 | eukaryotic translation elongation factor 1 complex |
IEA | -- | About this table
Antibodies for EEF1A2: Assays for EEF1A2: | Protein
Domains/ Families for EEF1A2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q05639
ProtoNet protein and cluster: Q05639 1 Blocks protein family: IPB004160 Elongation factor Tu
UniProtKB/Swiss-Prot: EF1A2_HUMAN, Q05639Similarity: Belongs to the GTP-binding elongation factor family. EF-Tu/EF-1A subfamily | Gene Function for EEF1A2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001958
Applied Biosystems Silencer® siRNAs for EEF1A2
Sigma-Aldrich siRNA for EEF1A2  Sigma-Aldrich shRNA for EEF1A2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001958                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001958                                  untagged cDNA clone in CMV expression vector: NM_001958 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001958
UniProtKB/Swiss-Prot: EF1A2_HUMAN, Q05639Function: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesisGenatlas biochemistry entry for EEF1A2:eukaryotic translation elongation factor 1,alpha 2,expressed in a tissue specific pattern8 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Eef1a2):
5 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for EEF1A2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/208 Interacting proteins for EEF1A2 (Q056391, 2 ENSP000002980493) via UniProtKB, MINT, and/or STRING (see all 208
)About this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006414 | translational elongation |
IEA | -- | | GO:0006916 | anti-apoptosis |
IEA | -- | About this table
|
Drugs & Compounds for EEF1A2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for EEF1A2
|
Transcripts for EEF1A2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001958
Sigma-Aldrich siRNA for EEF1A2  Sigma-Aldrich shRNA for EEF1A2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_001958 REFSEQ mRNAs for EEF1A2 gene: NM_001958.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001958               OriGene GFP tagged cDNA clone in CMV expression vector: NM_001958                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001958                                  untagged cDNA clone in CMV expression vector: NM_001958  Additional cDNA sequence: AB451389.1 AK307536.1 BC000432.2 BC018855.2 BC110409.1 CR589974.1 CR592792.1 CR593279.1 CR597004.1 CR597303.1 CR600141.1 CR602821.1 CR604699.1 CR608520.1 CR613690.1 CR614088.1 CR616067.1 CR621513.1 CR622432.1 CR626229.1 CR626526.1 L10340.1 X70940.1 16 DOTS entries: DT.95274009 DT.100763754 DT.99981613 DT.97864018 DT.100850016 DT.100850021 DT.120826333 DT.91718165 DT.100039572 DT.100662890 DT.100850017 DT.100850019 DT.120826369 DT.91988739 DT.97787482 DT.97855523 24/480 AceView cDNA sequences (see all 480
):BQ691785 BM473205 BU154026 CD613515 BQ933254 BQ955352 AA325548 CR616067 BQ439686 BM931580 BQ688565 CR614088 BQ927027 BQ894431 BU154371 CR604699 BQ931673 BQ689324 BM726022 F27731 BU153799 BQ877608 BQ687977 CR602821
highest scoring ESTs for EEF1A2:BG324992 BI600154 BM473205 BM758878 BM847500 BM847942 BQ637081 BQ894431 BU145452 BX460499 Unigene Cluster for EEF1A2: Eukaryotic translation elongation factor 1 alpha 2 Hs.433839 [show with all ESTs]Unigene Representative Sequence: BC110409
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for EEF1A2
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | · | 8c | |
| SP1: | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for EEF1A2
2 Ensembl transcripts including schematic representations: ENST00000298049
ENST00000217182
|
Expression for EEF1A2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| EEF1A2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for EEF1A2
1 / 2 / 3 4 probe-sets matching EEF1A2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TCTGCACCTC
SOURCE GeneReport for Unigene cluster: Hs.433839
Expression variation in blood from EXPOLDB for EEF1A2 UniProtKB/Swiss-Prot: EF1A2_HUMAN, Q05639Tissue specificity: Brain, heart, and skeletal muscle |
Orthologs for EEF1A2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for EEF1A2 gene from 5/22 species (see all 22
)
About this table Species with no ortholog for EEF1A2
ENSEMBL Gene Tree for EEF1A2 | Paralogs for EEF1A2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for EEF1A2 gene
- EEF1AL32
Pseudogenes
- 9 related pseudogenes
|
SNPs/Variants for EEF1A2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for EEF1A2 (up to first 250kb)
|
Disorders & Mutations for EEF1A2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 602959
|
Medical News for EEF1A2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for EEF1A2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/35 PubMed articles for EEF1A2 gene (see all 35
):- Tissue-dependent variation in the expression of elongation factor-1 alpha isoforms: isolation and characterisation of a cDNA encoding a novel variant of human elongation-factor 1 alpha. (PubMed id 8354261)2, 3, 4 Knudsen S.M.... Leffers H. (1993)
- The human elongation factor 1 A-2 gene (EEF1A2): complete sequence and characterization of gene structure and promoter activity. (PubMed id 10950927)1, 3, 4 Bischoff C.... Leffers H. (2000)
- Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)3, 4 Rush J.... Comb M.J. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)3, 4 Deloukas P....Rogers J. (2001)
- Assignment of human elongation factor 1alpha genes: EEF1A maps to chromosome 6q14 and EEF1A2 to 20q13.3. (PubMed id 8812466)2, 3 Lund A....Tommerup N. (1996)
- Cloning of human and mouse brain cDNAs coding for S1, the second member of the mammalian elongation factor-1 alpha gene family: analysis of a possible evolutionary pathway. (PubMed id 7945283)3, 4 Lee S.... Wang E. (1994)
- Eukaryotic elongation factor 1A2 cooperates with phosphatidylinositol-4 kinase III beta to stimulate production of filopodia through increased phosphatidylinositol-4,5 bisphosphate generation. (PubMed id 18474610)1, 3 Jeganathan S....Lee J.M. (2008)
- eEF1A2 activates Akt and stimulates Akt-dependent actin remodeling, invasion and migration. (PubMed id 17130842)1, 3 Amiri A....Lee J.M. (2007)
- Binding of elongation factor eEF1A2 to phosphatidylinositol 4-kinase beta stimulates lipid kinase activity and phosphatidylinositol 4-phosphate generation. (PubMed id 17088255)1, 3 Jeganathan S. and Lee J.M. (2007)
|
Search for EEF1A2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing EEF1A2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing EEF1A2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing EEF1A2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for EEF1A2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for EEF1A2:

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Incremental update: 13 Oct 2009
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