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Aliases for EEF1A2 Gene

Aliases for EEF1A2 Gene

  • Eukaryotic Translation Elongation Factor 1 Alpha 2 2 3
  • Eukaryotic Elongation Factor 1 A-2 3 4
  • EF-1-Alpha-2 3 4
  • Statin-S1 3 4
  • EEF1AL 3 4
  • STN 3 4
  • Elongation Factor 1-Alpha 2 3
  • Statin-Like 2
  • EEF1A-2 4
  • Statin 2
  • EF1A 3
  • STNL 3
  • HS1 3

External Ids for EEF1A2 Gene

Previous HGNC Symbols for EEF1A2 Gene

  • STNL
  • STN

Previous GeneCards Identifiers for EEF1A2 Gene

  • GC20M061996
  • GC20M062798
  • GC20M062845
  • GC20M061589
  • GC20M062119
  • GC20M058848

Summaries for EEF1A2 Gene

Entrez Gene Summary for EEF1A2 Gene

  • This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 2) is expressed in brain, heart and skeletal muscle, and the other isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas. This gene may be critical in the development of ovarian cancer. [provided by RefSeq, Mar 2014]

GeneCards Summary for EEF1A2 Gene

EEF1A2 (Eukaryotic Translation Elongation Factor 1 Alpha 2) is a Protein Coding gene. Diseases associated with EEF1A2 include legionellosis. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Gene Expression. GO annotations related to this gene include GTP binding and translation factor activity, RNA binding. An important paralog of this gene is EEF1A1.

UniProtKB/Swiss-Prot for EEF1A2 Gene

  • This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis

Gene Wiki entry for EEF1A2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EEF1A2 Gene

Genomics for EEF1A2 Gene

Regulatory Elements for EEF1A2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for EEF1A2 Gene

63,488,012 bp from pter
63,499,315 bp from pter
11,304 bases
Minus strand

Genomic View for EEF1A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EEF1A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EEF1A2 Gene

Proteins for EEF1A2 Gene

  • Protein details for EEF1A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Elongation factor 1-alpha 2
    Protein Accession:
    Secondary Accessions:
    • B5BUF3
    • E1P5J1
    • P54266
    • Q0VGC7

    Protein attributes for EEF1A2 Gene

    463 amino acids
    Molecular mass:
    50470 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for EEF1A2 Gene

neXtProt entry for EEF1A2 Gene

Proteomics data for EEF1A2 Gene at MOPED

Post-translational modifications for EEF1A2 Gene

  • Ubiquitination at Lys20, Lys30, Lys41, Lys44, Lys62, Lys146, Lys172, and Lys255
  • Modification sites at PhosphoSitePlus

Other Protein References for EEF1A2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for EEF1A2 Gene

Domains for EEF1A2 Gene

Suggested Antigen Peptide Sequences for EEF1A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q05639
  • Contains 1 tr-type G (guanine nucleotide-binding) domain.
  • Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
genes like me logo Genes that share domains with EEF1A2: view

No data available for Gene Families for EEF1A2 Gene

Function for EEF1A2 Gene

Molecular function for EEF1A2 Gene

GENATLAS Biochemistry: eukaryotic translation elongation factor 1,alpha 2,expressed in a tissue specific pattern
UniProtKB/Swiss-Prot Function: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis

Gene Ontology (GO) - Molecular Function for EEF1A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003746 translation elongation factor activity IEA --
GO:0003924 GTPase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0005525 GTP binding IEA --
GO:0008135 translation factor activity, RNA binding NAS 8812466
genes like me logo Genes that share ontologies with EEF1A2: view
genes like me logo Genes that share phenotypes with EEF1A2: view

Animal Model Products

CRISPR Products

miRNA for EEF1A2 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for EEF1A2 Gene

Localization for EEF1A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EEF1A2 Gene

Subcellular locations from

Jensen Localization Image for EEF1A2 Gene COMPARTMENTS Subcellular localization image for EEF1A2 gene
Compartment Confidence
cytosol 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for EEF1A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 NOT nucleus IDA 12426392
GO:0005737 cytoplasm IDA 12426392
GO:0005853 eukaryotic translation elongation factor 1 complex IEA --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with EEF1A2: view

Pathways for EEF1A2 Gene

genes like me logo Genes that share pathways with EEF1A2: view

Pathways by source for EEF1A2 Gene

1 BioSystems pathway for EEF1A2 Gene
2 KEGG pathways for EEF1A2 Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for EEF1A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006414 translational elongation IEA --
GO:0010035 response to inorganic substance IEA --
GO:0043065 positive regulation of apoptotic process IEA --
GO:0090218 positive regulation of lipid kinase activity IDA 17088255
genes like me logo Genes that share ontologies with EEF1A2: view

Compounds for EEF1A2 Gene

(4) HMDB Compounds for EEF1A2 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
Guanosine triphosphate
  • 5'-GTP
  • NFB Orthophosphate
  • Dihydrogen oxide
genes like me logo Genes that share compounds with EEF1A2: view

Transcripts for EEF1A2 Gene

mRNA/cDNA for EEF1A2 Gene

Unigene Clusters for EEF1A2 Gene

Eukaryotic translation elongation factor 1 alpha 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EEF1A2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EEF1A2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b · 8c
SP1: - -
SP2: -
SP3: - - - -
SP5: -

Relevant External Links for EEF1A2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EEF1A2 Gene

mRNA expression in normal human tissues for EEF1A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EEF1A2 Gene

This gene is overexpressed in Muscle - Skeletal (15.7) and Heart - Left Ventricle (6.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EEF1A2 Gene

SOURCE GeneReport for Unigene cluster for EEF1A2 Gene Hs.433839

mRNA Expression by UniProt/SwissProt for EEF1A2 Gene

Tissue specificity: Brain, heart, and skeletal muscle
genes like me logo Genes that share expressions with EEF1A2: view

In Situ Assay Products

Orthologs for EEF1A2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EEF1A2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia EEF1A2 35
  • 78.31 (n)
  • 92.41 (a)
EEF1A2 36
  • 99 (a)
(Bos Taurus)
Mammalia EEF1A2 35
  • 91.5 (n)
  • 100 (a)
EEF1A2 36
  • 100 (a)
(Canis familiaris)
Mammalia EEF1A2 36
  • 84 (a)
LOC102155289 35
  • 77.8 (n)
  • 92.62 (a)
(Mus musculus)
Mammalia Eef1a2 35
  • 89.13 (n)
  • 99.78 (a)
Eef1a2 16
Eef1a2 36
  • 100 (a)
(Monodelphis domestica)
Mammalia EEF1A2 36
  • 99 (a)
(Ornithorhynchus anatinus)
Mammalia EEF1A2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Eef1a2 35
  • 89.27 (n)
  • 99.78 (a)
(Gallus gallus)
Aves EEF1A2 35
  • 88.91 (n)
  • 99.57 (a)
EF1A 36
  • 100 (a)
(Anolis carolinensis)
Reptilia EEF1A2 36
  • 99 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia eef1a2 35
  • 84.23 (n)
  • 98.49 (a)
(Danio rerio)
Actinopterygii -- 35
eef1a2 35
  • 79.27 (n)
  • 94.17 (a)
eef1a2 36
  • 94 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003541 35
  • 78.99 (n)
  • 85.22 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ef1alpha100E 35
  • 77.68 (n)
  • 83.91 (a)
Ef1alpha48D 36
  • 84 (a)
Ef1alpha48D 37
  • 84 (a)
Ef1alpha100E 37
  • 83 (a)
(Caenorhabditis elegans)
Secernentea eef-1A.1 36
  • 84 (a)
eef-1A.2 36
  • 84 (a)
eft-3 37
  • 84 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TEF2 36
  • 80 (a)
(Zea mays)
Liliopsida Zm.3892 35
(Oryza sativa)
Liliopsida Os.12625 35
(Triticum aestivum)
Liliopsida Ta.2078 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 78 (a)
CSA.11100 36
  • 82 (a)
CSA.11147 36
  • 37 (a)
CSA.4537 36
  • 81 (a)
Species with no ortholog for EEF1A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for EEF1A2 Gene

Gene Tree for EEF1A2 (if available)
Gene Tree for EEF1A2 (if available)

Paralogs for EEF1A2 Gene

Paralogs for EEF1A2 Gene

Selected SIMAP similar genes for EEF1A2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with EEF1A2: view

Variants for EEF1A2 Gene

Sequence variations from dbSNP and Humsavar for EEF1A2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs178097 -- 63,492,015(+) atgaa(C/T)ggatg intron-variant
rs310604 -- 63,489,587(+) AGACC(A/G)GCCTG intron-variant
rs310605 -- 63,489,789(+) aaaaa(A/T)aaata intron-variant
rs310606 -- 63,489,961(+) ACCCG(C/G)GATTG intron-variant
rs310607 -- 63,490,349(+) CGTGA(A/G)CCACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EEF1A2 Gene

Variant ID Type Subtype PubMed ID
nsv9825 CNV Gain 18304495
dgv4618n71 CNV Loss 21882294
nsv913165 CNV Loss 21882294
dgv4630n71 CNV Loss 21882294
dgv4631n71 CNV Loss 21882294
nsv913189 CNV Loss 21882294
nsv913190 CNV Loss 21882294
dgv4633n71 CNV Loss 21882294
nsv834033 CNV Gain 17160897
dgv4634n71 CNV Loss 21882294
nsv913201 CNV Loss 21882294
dgv4635n71 CNV Gain+Loss 21882294
nsv834034 CNV Loss 17160897
dgv4636n71 CNV Loss 21882294
nsv913207 CNV Loss 21882294
dgv1344e1 CNV Complex 17122850
dgv4637n71 CNV Loss 21882294
nsv913213 CNV Loss 21882294
dgv4638n71 CNV Loss 21882294
dgv4639n71 CNV Loss 21882294
nsv470563 CNV Loss 18288195
nsv3448 CNV Insertion 18451855
esv2722931 CNV Deletion 23290073
esv2722932 CNV Deletion 23290073

Relevant External Links for EEF1A2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EEF1A2 Gene

Disorders for EEF1A2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for EEF1A2 Gene including...

Search for EEF1A2 Gene in MalaCards »

Relevant External Links for EEF1A2

Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with EEF1A2: view

No data available for UniProtKB/Swiss-Prot for EEF1A2 Gene

Publications for EEF1A2 Gene

  1. The human elongation factor 1 A-2 gene (EEF1A2): complete sequence and characterization of gene structure and promoter activity. (PMID: 10950927) Bischoff C. … Leffers H. (Genomics 2000) 3 4 23
  2. Tissue-dependent variation in the expression of elongation factor-1 alpha isoforms: isolation and characterisation of a cDNA encoding a novel variant of human elongation-factor 1 alpha. (PMID: 8354261) Knudsen S.M. … Leffers H. (Eur. J. Biochem. 1993) 2 3 4
  3. Cloning of human and mouse brain cDNAs coding for S1, the second member of the mammalian elongation factor-1 alpha gene family: analysis of a possible evolutionary pathway. (PMID: 7945283) Lee S. … Wang E. (Biochem. Biophys. Res. Commun. 1994) 3 4
  4. Eukaryotic elongation factor 1A2 cooperates with phosphatidylinositol-4 kinase III beta to stimulate production of filopodia through increased phosphatidylinositol-4,5 bisphosphate generation. (PMID: 18474610) Jeganathan S. … Lee J.M. (Mol. Cell. Biol. 2008) 3 23
  5. Structural models of human eEF1A1 and eEF1A2 reveal two distinct surface clusters of sequence variation and potential differences in phosphorylation. (PMID: 19636410) Soares D.C. … Abbott C.M. (PLoS ONE 2009) 3 23

Products for EEF1A2 Gene

Sources for EEF1A2 Gene

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