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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EEF1A2 Gene

protein-coding   GIFtS: 63
GCID: GC20M062119

Eukaryotic Translation Elongation Factor 1 Alpha 2

(Previous names: statin-like, statin)
(Previous symbols: STNL, STN)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Eukaryotic Translation Elongation Factor 1 Alpha 21 2     statin-like1
STN1 2 3     EF1A2
STNL1 2     HS12
Eukaryotic Elongation Factor 1 A-22 3     Elongation Factor 1-Alpha 22
EEF1AL2 3     Elongation Factor-1 Alpha2
EF-1-alpha-22 3     Statin S12
eEF1A-22 3     statin-S12
statin1     Statin-S13

External Ids:    HGNC: 31921   Entrez Gene: 19172   Ensembl: ENSG000001012107   OMIM: 6029595   UniProtKB: Q056393   

Export aliases for EEF1A2 gene to outside databases

Previous GC identifers: GC20M061996 GC20M062798 GC20M062845 GC20M061589 GC20M058848


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for EEF1A2 Gene:
This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the
enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 2) is expressed in brain, heart and
skeletal muscle, and the other isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and
pancreas. This gene may be critical in the development of ovarian cancer. Alternatively spliced transcript
variants encoding different isoforms have been found for this gene. (provided by RefSeq, Oct 2008)

GeneCards Summary for EEF1A2 Gene: 
EEF1A2 (eukaryotic translation elongation factor 1 alpha 2) is a protein-coding gene. Diseases associated with EEF1A2 include familial hyperlipidemia, and cerebrovascular accident. GO annotations related to this gene include translation factor activity, nucleic acid binding and GTP binding. An important paralog of this gene is EEF1A1.

UniProtKB/Swiss-Prot: EF1A2_HUMAN, Q05639
Function: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during
protein biosynthesis

Gene Wiki entry for EEF1A2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.2  NT_011333.6  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EEF1A2 gene promoter:
         SRF   NF-1   STAT1   Pax-5   SRF (504 AA)   Nkx2-5   FOXO1a   ATF   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEEF1A2 promoter sequence
   Search SABiosciences Chromatin IP Primers for EEF1A2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EEF1A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.3   Ensembl cytogenetic band:  20q13.33   HGNC cytogenetic band: 20q13.3

EEF1A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EEF1A2 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M062119:  view genomic region     (about GC identifiers)

Start:
62,119,366 bp from pter      End:
62,130,505 bp from pter
Size:
11,140 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: EF1A2_HUMAN, Q05639 (See protein sequence)
Recommended Name: Elongation factor 1-alpha 2  
Size: 463 amino acids; 50470 Da
Subunit: Monomer (By similarity)
Subcellular location: Nucleus (By similarity)
1 PDB 3D structure from and Proteopedia for EEF1A2:
3C5J (3D)    
Secondary accessions: B5BUF3 E1P5J1 P54266 Q0VGC7

Explore the universe of human proteins at neXtProt for EEF1A2: NX_Q05639

Explore proteomics data for EEF1A2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q05639

  • EEF1A2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    EEF1A2 Protein Expression
    REFSEQ proteins: NP_001949.1  
    ENSEMBL proteins: 
     ENSP00000298049   ENSP00000217182  

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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005853eukaryotic translation elongation factor 1 complex IEA--
    GO:0043025neuronal cell body IEA--

    EEF1A2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/7 InterPro protein domains (see all 7):
     IPR027417 P-loop_NTPase
     IPR009001 Transl_elong_EF1A/Init_IF2_C
     IPR000795 EF_GTP-bd_dom
     IPR004160 Transl_elong_EFTu/EF1A_C
     IPR004161 Transl_elong_EFTu/EF1A_2

    Graphical View of Domain Structure for InterPro Entry Q05639

    ProtoNet protein and cluster: Q05639

    1 Blocks protein domain: IPB004160 Elongation factor Tu

    UniProtKB/Swiss-Prot: EF1A2_HUMAN, Q05639
    Similarity: Belongs to the GTP-binding elongation factor family. EF-Tu/EF-1A subfamily


    EEF1A2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EF1A2_HUMAN, Q05639
    Function: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during
    protein biosynthesis

         Genatlas biochemistry entry for EEF1A2:
    eukaryotic translation elongation factor 1,alpha 2,expressed in a tissue specific pattern

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003746translation elongation factor activity IEA--
    GO:0003924GTPase activity IEA--
    GO:0005515protein binding ----
    GO:0005525GTP binding IEA--
    GO:0008135translation factor activity, nucleic acid binding NAS8812466
         
    EEF1A2 for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Eef1a2):
     behavior/neurological  cellular  growth/size  hematopoietic system  immune system 
     mortality/aging  muscle  nervous system 

    EEF1A2 for phenotypes           About GeneDecksing

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    SwitchGear 3'UTR luciferase reporter plasmidEEF1A2 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for EEF1A2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Translation Factors
    Translation Factors
    2Legionellosis
    Legionellosis
    3RNA transport
    RNA transport

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for EEF1A2
        Translation Factors



    2         Kegg Pathways  (Kegg details for EEF1A2):
        RNA transport
    Legionellosis


    EEF1A2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for EEF1A2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/227 Interacting proteins for EEF1A2 (Q056392, 3 ENSP000002171824) via UniProtKB, MINT, STRING, and/or I2D (see all 227)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NFKB1P198382, 3, ENSP000002265744MINT-48539 MINT-48654 I2D: score=1 STRING: ENSP00000226574
    NFKB2Q006532, 3MINT-48716 MINT-48580 I2D: score=2 
    TRAF2Q129332, 3MINT-49540 I2D: score=3 
    IKBKGQ9Y6K92, 3MINT-48161 I2D: score=2 
    MAP3K1Q132332, 3MINT-48294 I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006414translational elongation ----
    GO:0010035response to inorganic substance IEA--
    GO:0043066negative regulation of apoptotic process IEA--

    EEF1A2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for EEF1A2 (EF1A2)

    4 HMDB Compounds for EEF1A2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Search CenterWatch for drugs/clinical trials and news about EEF1A2 / EF1A2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for EEF1A2 gene: 
    NM_001958.3  

    Unigene Cluster for EEF1A2:

    Eukaryotic translation elongation factor 1 alpha 2
    Hs.433839  [show with all ESTs]
    Unigene Representative Sequence: NM_001958
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000298049 ENST00000217182(uc002yfe.1)

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    Additional mRNA sequence: 

    AB451389.1 AK307536.1 BC000432.2 BC018855.2 BC110409.1 L10340.1 X70940.1 

    16 DOTS entries:

    DT.95274009  DT.100763754  DT.99981613  DT.97864018  DT.100850016  DT.100850021  DT.120826333  DT.91718165 
    DT.100039572  DT.100662890  DT.100850017  DT.100850019  DT.120826369  DT.91988739  DT.97787482  DT.97855523 

    24/480 AceView cDNA sequences (see all 480):

    BM727956 CR593279 BQ691785 BM710104 BU181421 BM452523 BM931580 BQ430062 
    CR589974 CR626229 BQ686618 BQ898675 BQ687977 BQ688565 BX459941 CR622432 
    CR608520 BX446081 BM932012 BQ687882 BQ434847 BM703726 AA325548 BU856758 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for EEF1A2    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b · 8c
    SP1:              -                                                     -                                       
    SP2:              -                                                                                             
    SP3:                                            -     -     -           -                                       
    SP4:                                                                                                            
    SP5:                                                                                      -                     


    ECgene alternative splicing isoforms for EEF1A2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EEF1A2 expression in normal human tissues (normalized intensities)      EEF1A2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTGCACCTC
    EEF1A2 Expression
    About this image


    EEF1A2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Medulla Oblongata
             Human Hippocampal Astrocytes   
             Subthalamic Nucleus   
     
     Neuron (Nervous System)    fully expand to see all 2 entries
             Human Neurons   
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Human Retinal Pigment Epithelial Cells (HRPEpiC)   
     
     Epithelium (Uncategorized)    fully expand to see all 2 entries
             Human Renal Epithelial Cells (HREpiC)   
     
     Neural Crest (Gastrulation Derivatives)
             PureStem 4D20.8, NCr-fac Progenitor

    See EEF1A2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EEF1A2

    SOURCE GeneReport for Unigene cluster: Hs.433839

    UniProtKB/Swiss-Prot: EF1A2_HUMAN, Q05639
    Tissue specificity: Brain, heart, and skeletal muscle

        SABiosciences Expression via Pathway-Focused PCR Arrays including EEF1A2: 
              Huntington's Disease in human mouse rat
              Apoptosis 384HT in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for EEF1A2 gene from 10/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Eef1a21 , 5 eukaryotic translation elongation factor 1 alpha 21, 5 89.13(n)1
    99.78(a)1
      2 (103.60 cM)5
    136281  NM_007906.21  NP_031932.11 
     1811476535 
    chicken
    (Gallus gallus)
    Aves EEF1A21 eukaryotic translation elongation factor 1 alpha 2 88.91(n)
    99.57(a)
      419244  NM_001032398.2  NP_001027570.1 
    lizard
    (Anolis carolinensis)
    Reptilia EEF1A26
    Elongation factor 1-alpha
    99(a)
    1 ↔ 1
    4(154186116-154224079)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC054279.12   -- 79.82(n)    BC054279.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC064291.12   -- 81.52(n)   30516  BC064291.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ef1alpha48D3
    Ef1alpha100E1
    translational elongation translation
    elongation more3
    Elongation factor 1alpha100E1
    84(a)
    (best of 2)3
    77.68(n)1
    83.91(a)1
      48D13
    437361  NM_079872.41  NP_524611.11 
    worm
    (Caenorhabditis elegans)
    Secernentea eft-33 Elongation factor 1-alpha 84(a)   III(7041894-7043435)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TEF16
    Translational elongation factor EF-1 alpha; also e...
    80(a)
    1 → many
    XVI(700594-701970)
    Alicante grape
    (Vitis vinifera)
    eudicotyledons CF207663.12   -- 79.03(n)    CF207663.1 
    rice
    (Oryza sativa)
    Liliopsida Os.126252 Oryza sativa mRNA for EF-1 alpha, complete cds 81.07(n)    AK072648.1 


    ENSEMBL Gene Tree for EEF1A2 (if available)
    TreeFam Gene Tree for EEF1A2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for EEF1A2 gene
    EEF1A12  
    8 SIMAP similar genes for EEF1A2 using alignment to 1 protein entry:     EF1A2_HUMAN:
    EEF1A1P5    EEF1A1    EEF1A1L14    PTI-1    EEF1A    HBS1L
    GSPT2    GSPT1

    EEF1A2 for paralogs           About GeneDecksing


    5/20 Pseudogenes.org Pseudogenes for EEF1A2 (see all 20)
    PGOHUM00000238627 PGOHUM00000242626 PGOHUM00000258601 PGOHUM00000239367 PGOHUM00000248554


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/418 SNPs in EEF1A2 are shown (see all 418)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0693954
    ----see VAR_0693952 G S mis40--------
    rs347883001,2
    C,F--62118872(+) AACCAC/TGTACA 1 -- int16Minor allele frequency- T:0.15NA EA 248
    rs1902277491,2
    --62118913(+) GGTACA/GGGCTG 1 -- int10--------
    rs14121611,2
    C,F,H--62118936(-) GCTAAG/CCCGGT 1 -- int128Minor allele frequency- C:0.25NS EA NA WA CSA 2771
    rs1420417191,2
    --62118963(+) GTGTGC/TGGGGC 1 -- int10--------
    rs359481221,2
    C,F--62118964(+) TGTGCG/AGGGCC 1 -- int16Minor allele frequency- A:0.15NA EA 248
    rs1828153111,2
    --62119108(+) CCATGA/GAGAAG 1 -- int10--------
    rs17416211,2
    C,F,H--62119121(-) TGGCTG/TTGAGG 1 -- int125Minor allele frequency- T:0.19MN NS EA NA WA CSA 2533
    rs622092781,2
    C,F--62119232(+) GCAGGG/AGACCA 1 -- int15Minor allele frequency- A:0.14NA EA 246
    rs17416201,2
    C,F--62119253(-) TGGGCG/TGTGGG 1 -- int18Minor allele frequency- T:0.20MN NA CSA WA EA 549

    HapMap Linkage Disequilibrium report for EEF1A2 (62119366 - 62130505 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/24 variations for EEF1A2 (see all 24):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2722932CNV Deletion23290073
    esv2722931CNV Deletion23290073
    nsv3448CNV Insertion18451855
    nsv913213CNV Loss21882294
    nsv913165CNV Loss21882294
    dgv4618n71CNV Loss21882294
    nsv913207CNV Loss21882294
    dgv4636n71CNV Loss21882294
    dgv4630n71CNV Loss21882294
    dgv4639n71CNV Loss21882294


    Human Gene Mutation Database (HGMD): EEF1A2
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for EEF1A2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602959    OMIM disorders: --

    14 diseases for EEF1A2:    About MalaCards
    familial hyperlipidemia    cerebrovascular accident    ovarian cancer    plasmacytoma
    lung adenocarcinoma    hypercholesterolemia    huntington's disease    adenocarcinoma
    alzheimer's disease    pancreatitis    lung cancer    prostate cancer
    prostatitis    neuronitis


    EEF1A2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Human Genome Epidemiology (HuGE) Navigator: EEF1A2 (1 document)

    Export disorders for EEF1A2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EEF1A2 gene, integrated from 9 sources (see all 84):
    (articles sorted by number of sources associating them with EEF1A2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Tissue-dependent variation in the expression of elongation factor-1 alpha isoforms: isolation and characterisation of a cDNA encoding a novel variant of human elongation-factor 1 alpha. (PubMed id 8354261)1, 2, 3 Knudsen S.M.... Leffers H. (1993)
    2. The human elongation factor 1 A-2 gene (EEF1A2): complete sequence and characterization of gene structure and promoter activity. (PubMed id 10950927)1, 2, 9 Bischoff C.... Leffers H. (2000)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    5. Assignment of human elongation factor 1alpha genes: EEF1A maps to chromosome 6q14 and EEF1A2 to 20q13.3. (PubMed id 8812466)1, 3 Lund A....Tommerup N. (1996)
    6. Cloning of human and mouse brain cDNAs coding for S1, the second member of the mammalian elongation factor-1 alpha gene family: analysis of a possible evolutionary pathway. (PubMed id 7945283)1, 2 Lee S.... Wang E. (1994)
    7. Structural models of human eEF1A1 and eEF1A2 reveal t wo distinct surface clusters of sequence variation and potential differences in phosphorylation. (PubMed id 19636410)1, 9 Soares D.C....Abbott C.M. (2009)
    8. Eukaryotic elongation factor 1A2 cooperates with phosphatidylinositol-4 kinase III beta to stimulate production of filopodia through increased phosphatidylinositol-4,5 bisphosphate generation. (PubMed id 18474610)1, 9 Jeganathan S....Lee J.M. (2008)
    9. Binding of elongation factor eEF1A2 to phosphatidylinositol 4-kinase beta stimulates lipid kinase activity and phosphatidylinositol 4-phosphate generation. (PubMed id 17088255)1, 9 Jeganathan S. and Lee J.M. (2007)
    10. eEF1A2 activates Akt and stimulates Akt-dependent actin remodeling, invasion and migration. (PubMed id 17130842)1, 9 Amiri A....Lee J.M. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1917 HGNC: 3192 AceView: EEF1A2 Ensembl:ENSG00000101210 euGenes: HUgn1917
    ECgene: EEF1A2 Kegg: 1917 H-InvDB: EEF1A2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for EEF1A2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EEF1A2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for EEF1A2 gene:
    Search GeneIP for patents involving EEF1A2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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