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EEF1A1P5 Gene

pseudogene   GIFtS: 21
GCID: GC09P135962

Eukaryotic Translation Elongation Factor 1 Alpha 1 Pseudogene...

(Previous name: eukaryotic translation elongation factor 1 alpha-like 3)
(Previous symbol: EEF1AL3)
  See EEF1A1P5-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Eukaryotic Translation Elongation Factor 1 Alpha 1 Pseudogene 51 2     EF-1-Alpha-Like 33
EEF1AL31 2 3     Eukaryotic Elongation Factor 1 A-Like 33
Eukaryotic Translation Elongation Factor 1 Alpha-Like 31     Eukaryotic Translation Elongation Factor 1 Alpha-1 Pseudogene 53
EEF1A-Like 33     

External Ids:    HGNC: 32001   Entrez Gene: 1580782   Ensembl: ENSG000001962057   UniProtKB: Q5VTE03   

Export aliases for EEF1A1P5 gene to outside databases

Previous GC identifers: GC09P135896 GC09P105388 GC09P135897 GC09P135910


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for EEF1A1P5 Gene:
EEF1A1P5 (eukaryotic translation elongation factor 1 alpha 1 pseudogene 5) is a pseudogene. Diseases associated with EEF1A1P5 include multiple myeloma. GO annotations related to this gene include GTP binding and translation elongation factor activity.

UniProtKB/Swiss-Prot: EF1A3_HUMAN, Q5VTE0
Function: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during
protein biosynthesis (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for EEF1A1P5
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EEF1A1P5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.13   Ensembl cytogenetic band:  9q34.13   HGNC cytogenetic band: 9q34.13

EEF1A1P5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EEF1A1P5 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P135962:  view genomic region     (about GC identifiers)

Start:
135,894,816 bp from pter      End:
135,896,562 bp from pter
Size:
1,747 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: EF1A3_HUMAN, Q5VTE0 (See protein sequence)
Recommended Name: Putative elongation factor 1-alpha-like 3  
Size: 462 amino acids; 50185 Da
Caution: Could be the product of a pseudogene

Explore the universe of human proteins at neXtProt for EEF1A1P5: NX_Q5VTE0

Reactome Protein details: Q5VTE0

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Selected InterPro protein domains (see all 7):
 IPR027417 P-loop_NTPase
 IPR009001 Transl_elong_EF1A/Init_IF2_C
 IPR000795 EF_GTP-bd_dom
 IPR004160 Transl_elong_EFTu/EF1A_C
 IPR004161 Transl_elong_EFTu/EF1A_2

Graphical View of Domain Structure for InterPro Entry Q5VTE0

ProtoNet protein and cluster: Q5VTE0

UniProtKB/Swiss-Prot: EF1A3_HUMAN, Q5VTE0
Similarity: Belongs to the GTP-binding elongation factor family. EF-Tu/EF-1A subfamily


Find genes that share domains with EEF1A1P5           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: EF1A3_HUMAN, Q5VTE0
Function: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during
protein biosynthesis (By similarity)

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003746translation elongation factor activity IEA--
GO:0003924GTPase activity IEA--
GO:0005525GTP binding IEA--
     
Find genes that share ontologies with EEF1A1P5           About GenesLikeMe


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
EF1A3_HUMAN, Q5VTE0: Cytoplasm (By similarity)

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005615extracellular space IDA--
GO:0005737cytoplasm IEA--
GO:0070062extracellular vesicular exosome IDA--

Find genes that share ontologies with EEF1A1P5           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for EEF1A1P5 About    
See pathways by source

SuperPathContained pathways About
1Influenza Viral RNA Transcription and Replication
Eukaryotic Translation Elongation0.93
Translation0.82
2Gene Expression
Gene Expression0.40
3Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Metabolism of proteins0.30


Find genes that share SuperPaths with EEF1A1P5           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 Reactome Pathway for EEF1A1P5
    Eukaryotic Translation Elongation


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Interactions:

    Search GeneGlobe Interaction Network for EEF1A1P5

Selected Interacting proteins for EEF1A1P5 (Q5VTE03) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
InteractantInteraction Details
GeneCardExternal ID(s)
CCL18P557743I2D: score=1 
DVL2O146413I2D: score=1 
JDP2Q8WYK23I2D: score=1 
MYSM1Q5VVJ23I2D: score=1 
TLR2O606033I2D: score=1 
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for EEF1A1P5 (EF1A3)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000436459 ENST00000501580
miRNA
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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EEF1A1P5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
EEF1A1P5 Expression
About this image

EEF1A1P5 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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  --

ENSEMBL Gene Tree for EEF1A1P5 (if available)
TreeFam Gene Tree for EEF1A1P5 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for EEF1A1P5 gene
8 SIMAP similar genes for EEF1A1P5 using alignment to 1 protein entry:     EF1A3_HUMAN:
EEF1A1L14    EEF1A1    PTI-1    EEF1A2    EEF1A    HBS1L
GSPT2    GSPT1

Find genes that share paralogs with EEF1A1P5           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing EEF1A1P5
DNA2.0 Custom Variant and Variant Library Synthesis for EEF1A1P5

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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1 disease for EEF1A1P5:    
About MalaCards
multiple myeloma


Find genes that share disorders with EEF1A1P5           About GenesLikeMe


Export disorders for EEF1A1P5 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for EEF1A1P5 gene, integrated from 10 sources (see all 12):
(articles sorted by number of sources associating them with EEF1A1P5)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Assignment of human elongation factor 1alpha genes: EEF1A maps to chromosome 6q14 and EEF1A2 to 20q13.3. (PubMed id 8812466)1, 2, 3 Lund A.... Tommerup N. (Genomics 1996)
  2. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. (PubMed id 23398456)1 Bett J.S....Hay R.T. (Biochem. J. 2013)
  3. Profiling of Parkin-binding partners using tandem affinity purification. (PubMed id 24244333)1 Zanon A....Pichler I. (PLoS ONE 2013)
  4. Viral immune modulators perturb the human molecular network by common and unique strategies. (PubMed id 22810585)1 Pichlmair A....Superti-Furga G. (Nature 2012)
  5. Proteomic analysis of I+4I^1 integrin adhesion complexes reveals I+-subunit-dependent protein recruitment. (PubMed id 22623428)1 Byron A....Humphries M.J. (Proteomics 2012)
  6. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
  7. Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. (PubMed id 22118674)1 Altun M....Kessler B.M. (amp 2011)
  8. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)
  9. Identification of ubiquitinated proteins from human multiple myeloma U266 cells by proteomics. (PubMed id 22108332)1 Jia H....He Q. (Biomed. Environ. Sci. 2011)
  10. Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase. (PubMed id 19287380)1 Maddika S. and Chen J. (Nat. Cell Biol. 2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 158078 HGNC: 3200 Ensembl:ENSG00000196205 euGenes: HUgn158078 ECgene: EEF1A1P5
H-InvDB: EEF1A1P5

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for EEF1A1P5 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for EEF1A1P5 gene:
Search GeneIP for patents involving EEF1A1P5

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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