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Aliases for EEF1A1 Gene

Aliases for EEF1A1 Gene

  • Eukaryotic Translation Elongation Factor 1 Alpha 1 2 3 5
  • Leukocyte Receptor Cluster (LRC) Member 7 2 3
  • Leukocyte Receptor Cluster Member 7 3 4
  • Eukaryotic Elongation Factor 1 A-1 3 4
  • Elongation Factor Tu 3 4
  • EF-1-Alpha-1 3 4
  • EEF1A-1 3 4
  • EEF1A 3 4
  • LENG7 3 4
  • EF-Tu 3 4
  • EF1A 3 4
  • Eukaryotic Translation Elongation Factor 1 Alpha 1-Like 14 3
  • Glucocorticoid Receptor AF-1 Specific Elongation Factor 3
  • Translation Elongation Factor 1 Alpha 1-Like 14 3
  • Elongation Factor 1 Alpha Subunit 3
  • Prostate Tumor-Inducing Protein 1 3
  • Cervical Cancer Suppressor 3 3
  • Elongation Factor 1-Alpha 1 3
  • CTCL Tumor Antigen 3
  • EF1a-Like Protein 3
  • HNGC:16303 3
  • GRAF-1EF 3
  • CCS-3 3
  • EE1A1 3
  • EEF-1 3
  • CCS3 3
  • PTI1 3

External Ids for EEF1A1 Gene

Previous HGNC Symbols for EEF1A1 Gene

  • EF1A
  • EEF1A
  • LENG7

Previous GeneCards Identifiers for EEF1A1 Gene

  • GC06M074183
  • GC06M074221
  • GC06M074222
  • GC06M074282
  • GC06M074225

Summaries for EEF1A1 Gene

Entrez Gene Summary for EEF1A1 Gene

  • This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas, and the other isoform (alpha 2) is expressed in brain, heart and skeletal muscle. This isoform is identified as an autoantigen in 66% of patients with Felty syndrome. This gene has been found to have multiple copies on many chromosomes, some of which, if not all, represent different pseudogenes. [provided by RefSeq, Jul 2008]

GeneCards Summary for EEF1A1 Gene

EEF1A1 (Eukaryotic Translation Elongation Factor 1 Alpha 1) is a Protein Coding gene. Diseases associated with EEF1A1 include Retinitis Pigmentosa-40 and Cutaneous Anthrax. Among its related pathways are Protein methylation and Translational Control. GO annotations related to this gene include poly(A) RNA binding and protein kinase binding.

UniProtKB/Swiss-Prot for EEF1A1 Gene

  • This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.

Gene Wiki entry for EEF1A1 Gene

Additional gene information for EEF1A1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EEF1A1 Gene

Genomics for EEF1A1 Gene

Regulatory Elements for EEF1A1 Gene

Enhancers for EEF1A1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H073577 2 FANTOM5 Ensembl ENCODE dbSUPER 19.6 -55.9 -55891 5 HDGF FOXA2 ARNT ARID4B DMAP1 YY1 ZNF766 ZNF143 ZNF207 ZNF548 SLC17A5 MTO1 EEF1A1 LOC105377857 CD109 MB21D1 GC06P073558 GC06P073601
GH06H073513 1.7 Ensembl ENCODE dbSUPER 21.4 +4.7 4669 11 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 ZC3H11A ZFP41 MEF2D MTO1 EEF1A1 EIF3EP1 SLC17A5 OOEP-AS1 KHDC1P1 ENSG00000229852 KCNQ5-AS1 GC06M073517 GC06M073519
GH06H073584 2 FANTOM5 Ensembl ENCODE dbSUPER 17.9 -62.3 -62339 3 HDGF PKNOX1 FOXA2 MLX ARNT FEZF1 ZNF2 YY1 SMARCB1 ZNF592 SLC17A5 EEF1A1 LOC105377857 MB21D1 CD109 GC06P073601 GC06P073558
GH06H073460 1.1 ENCODE 30.5 +62.0 61963 2 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SP3 ZC3H11A ZHX2 MTO1 EEF1A1 KHDC1 SLC17A5 EIF3EP1 CD109 RPL39P3 RNU6-975P
GH06H073388 1.2 Ensembl ENCODE 11.9 +134.8 134788 1 ATF1 ARNT ZNF2 ZNF766 GLIS2 GATA2 ELK1 ZNF143 KLF7 ATF7 EEF1A1 KHDC3L DPPA5 RPS6P8 RPL39P3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EEF1A1 on UCSC Golden Path with GeneCards custom track

Promoters for EEF1A1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000198851 97 1001 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF766

Genomic Location for EEF1A1 Gene

Chromosome:
6
Start:
73,515,750 bp from pter
End:
73,523,797 bp from pter
Size:
8,048 bases
Orientation:
Minus strand

Genomic View for EEF1A1 Gene

Genes around EEF1A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EEF1A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EEF1A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EEF1A1 Gene

Proteins for EEF1A1 Gene

  • Protein details for EEF1A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P68104-EF1A1_HUMAN
    Recommended name:
    Elongation factor 1-alpha 1
    Protein Accession:
    P68104
    Secondary Accessions:
    • P04719
    • P04720
    • Q6IQ15

    Protein attributes for EEF1A1 Gene

    Size:
    462 amino acids
    Molecular mass:
    50141 Da
    Quaternary structure:
    • Found in a nuclear export complex with XPO5, EEF1A1, Ran and aminoacylated tRNA. Interacts with PARP1, TXK, XPO5 and KARS. May interact with ERGIC2. Interacts with IFIT1 (via TPR repeats 4-7) (By similarity). Interacts with DLC1, facilitating distribution to the membrane periphery and ruffles upon growth factor stimulation. Interacts with ZPR1; the interaction occurs in a epidermal growth factor (EGF)-dependent manner. Interacts with PPP1R16B (PubMed:26497934).
    SequenceCaution:
    • Sequence=AAA52367.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for EEF1A1 Gene

    Alternative splice isoforms for EEF1A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EEF1A1 Gene

Post-translational modifications for EEF1A1 Gene

  • ISGylated.
  • Phosphorylated by TXK. Phosphorylation by PASK increases translation efficiency. Phosphorylated by ROCK2 (PubMed:26497934).
  • Trimethylated at Lys-79 by EEF1AKMT1 (PubMed:26545399). Methylated at Lys-165 by EEF1AKMT3, methylation by EEF1AKMT3 is dynamic as well as inducible by stress conditions, such as ER-stress, and plays a regulatory role on mRNA translation (PubMed:28108655). Trimethylated at Lys-318 by EEF1AKMT2 (PubMed:25144183).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for EEF1A1 (EEF1A1)

No data available for DME Specific Peptides for EEF1A1 Gene

Domains & Families for EEF1A1 Gene

Gene Families for EEF1A1 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

P68104

UniProtKB/Swiss-Prot:

EF1A1_HUMAN :
  • Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
Family:
  • Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
genes like me logo Genes that share domains with EEF1A1: view

Function for EEF1A1 Gene

Molecular function for EEF1A1 Gene

GENATLAS Biochemistry:
eukaryotic translation elongation factor 1,alpha 1,ubiquitously expressed
UniProtKB/Swiss-Prot Function:
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.
UniProtKB/Swiss-Prot Induction:
By homocysteine (HC), may mediate accelerated synthesis of free thiol-containing proteins in response to HC-induced oxidative stress.

Gene Ontology (GO) - Molecular Function for EEF1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding IDA 12426392
GO:0000166 nucleotide binding IEA --
GO:0003723 RNA binding IDA 22658674
GO:0003746 translation elongation factor activity TAS,IEA 17595531
GO:0003924 GTPase activity IBA,IEA --
genes like me logo Genes that share ontologies with EEF1A1: view
genes like me logo Genes that share phenotypes with EEF1A1: view

Animal Model Products

CRISPR Products

miRNA for EEF1A1 Gene

miRTarBase miRNAs that target EEF1A1

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for EEF1A1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EEF1A1 Gene

Localization for EEF1A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EEF1A1 Gene

Cytoplasm. Nucleus. Nucleus, nucleolus. Cell membrane. Note=Colocalizes with DLC1 at actin-rich regions in the cell periphery (PubMed:19158340). Translocates together with ZPR1 from the cytoplasm to the nucleus and nucleolus after treatment with mitogens (PubMed:8650580). Localization at the cell membrane depends on EEF1A1 phosphorylation status and the presence of PPP1R16B (PubMed:26497934). {ECO:0000269 PubMed:19158340, ECO:0000269 PubMed:26497934, ECO:0000269 PubMed:8650580}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EEF1A1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 5
nucleus 5
cytosol 5
lysosome 4
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for EEF1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 23580065
GO:0005634 nucleus IDA,IEA 8743958
GO:0005730 nucleolus IDA,IEA 9852145
GO:0005737 cytoplasm TAS,IEA 3512269
genes like me logo Genes that share ontologies with EEF1A1: view

Pathways & Interactions for EEF1A1 Gene

genes like me logo Genes that share pathways with EEF1A1: view

Pathways by source for EEF1A1 Gene

1 Cell Signaling Technology pathway for EEF1A1 Gene
1 BioSystems pathway for EEF1A1 Gene

SIGNOR curated interactions for EEF1A1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for EEF1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006412 translation IEA --
GO:0006414 translational elongation TAS,IEA 8812466
GO:0006479 protein methylation TAS --
genes like me logo Genes that share ontologies with EEF1A1: view

Drugs & Compounds for EEF1A1 Gene

(39) Drugs for EEF1A1 Gene - From: DrugBank, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved Pharma Target 188
Zinc Approved Pharma Target 2359
Water Approved Pharma 0
Guanosine diphosphate Experimental Pharma Target 0
Guanosine triphosphate Experimental Pharma 0

(27) Additional Compounds for EEF1A1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2

(1) ApexBio Compounds for EEF1A1 Gene

genes like me logo Genes that share compounds with EEF1A1: view

Drug Products

Transcripts for EEF1A1 Gene

Unigene Clusters for EEF1A1 Gene

Eukaryotic translation elongation factor 1 alpha 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for EEF1A1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for EEF1A1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6
SP1:
SP2:
SP3:

Relevant External Links for EEF1A1 Gene

GeneLoc Exon Structure for
EEF1A1
ECgene alternative splicing isoforms for
EEF1A1

Expression for EEF1A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EEF1A1 Gene

Protein differential expression in normal tissues from HIPED for EEF1A1 Gene

This gene is overexpressed in Breast (23.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EEF1A1 Gene



Protein tissue co-expression partners for EEF1A1 Gene

NURSA nuclear receptor signaling pathways regulating expression of EEF1A1 Gene:

EEF1A1

SOURCE GeneReport for Unigene cluster for EEF1A1 Gene:

Hs.535192

mRNA Expression by UniProt/SwissProt for EEF1A1 Gene:

P68104-EF1A1_HUMAN
Tissue specificity: Brain, placenta, lung, liver, kidney, pancreas but barely detectable in heart and skeletal muscle.

Evidence on tissue expression from TISSUES for EEF1A1 Gene

  • Blood(5)
  • Eye(5)
  • Heart(5)
  • Intestine(5)
  • Kidney(5)
  • Liver(5)
  • Lung(5)
  • Pancreas(5)
  • Skin(5)
  • Spleen(5)
  • Stomach(5)
  • Nervous system(5)
  • Bone(4.9)
  • Muscle(4.9)
  • Thyroid gland(4.6)
  • Lymph node(3.1)
  • Adrenal gland(3)
  • Bone marrow(3)
  • Gall bladder(2.8)
genes like me logo Genes that share expression patterns with EEF1A1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for EEF1A1 Gene

Orthologs for EEF1A1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EEF1A1 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 100 (a)
OneToMany
-- 34
  • 54 (a)
OneToMany
dog
(Canis familiaris)
Mammalia EEF1A1 34
  • 100 (a)
OneToOne
LOC102151992 33
  • 92.57 (n)
chimpanzee
(Pan troglodytes)
Mammalia EEF1A1 34 33
  • 99.86 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EEF1A1 34
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eef1a1 16 34 33
  • 91.85 (n)
cow
(Bos Taurus)
Mammalia EEF1A1 33 34
  • 91.77 (n)
rat
(Rattus norvegicus)
Mammalia Eef1a1 33
  • 91.63 (n)
chicken
(Gallus gallus)
Aves EEF1A 34
  • 99 (a)
OneToOne
EEF1A1 33
  • 86.29 (n)
lizard
(Anolis carolinensis)
Reptilia EEF1A1 34
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eef1a1o 33
  • 78.26 (n)
MGC75658 33
zebrafish
(Danio rerio)
Actinopterygii eef1a1b 34
  • 94 (a)
OneToMany
eef1a1a 33 34
  • 81.46 (n)
-- 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1771 33
fruit fly
(Drosophila melanogaster)
Insecta Ef1alpha48D 35
  • 85 (a)
Ef1alpha100E 35 34
  • 84 (a)
worm
(Caenorhabditis elegans)
Secernentea eft-3 35
  • 83 (a)
eef-1A.1 34
  • 83 (a)
ManyToMany
eef-1A.2 34
  • 83 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TEF2 34
  • 81 (a)
OneToMany
TEF1 36 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G07940 33
  • 71.99 (n)
soybean
(Glycine max)
eudicotyledons Gma.10761 33
rice
(Oryza sativa)
Liliopsida Os03g0177500 33
  • 71.66 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11100 34
  • 84 (a)
ManyToMany
CSA.4537 34
  • 82 (a)
ManyToMany
-- 34
  • 78 (a)
ManyToMany
CSA.11147 34
  • 37 (a)
ManyToMany
Species where no ortholog for EEF1A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EEF1A1 Gene

ENSEMBL:
Gene Tree for EEF1A1 (if available)
TreeFam:
Gene Tree for EEF1A1 (if available)

Paralogs for EEF1A1 Gene

genes like me logo Genes that share paralogs with EEF1A1: view

No data available for Paralogs for EEF1A1 Gene

Variants for EEF1A1 Gene

Sequence variations from dbSNP and Humsavar for EEF1A1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000235376 -- 73,520,422(+) GGGAA(A/G)CGGCC intron-variant, utr-variant-5-prime
rs1000315082 -- 73,517,341(+) TCCCA(C/T)AGCTT downstream-variant-500B, utr-variant-3-prime
rs1000407491 -- 73,521,641(+) CGCCC(C/T)TCCCG upstream-variant-2KB
rs1000790827 -- 73,517,217(+) TTAAC(A/G)TTGGT downstream-variant-500B, utr-variant-3-prime
rs1001396441 -- 73,518,540(+) ACTGG(A/G)GCAAA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for EEF1A1 Gene

Variant ID Type Subtype PubMed ID
esv2675873 CNV deletion 23128226
esv2763576 CNV gain 21179565
esv3609512 CNV loss 21293372
nsv463153 CNV loss 19166990
nsv5350 CNV deletion 18451855
nsv603693 CNV loss 21841781
nsv981157 CNV duplication 23825009

Variation tolerance for EEF1A1 Gene

Residual Variation Intolerance Score: 25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.40; 8.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EEF1A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EEF1A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EEF1A1 Gene

Disorders for EEF1A1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for EEF1A1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
retinitis pigmentosa-40
  • retinitis pigmentosa 40
cutaneous anthrax
  • anthrax, skin type
prostate cancer
  • prostate cancer, hereditary, 5
bardet-biedl syndrome
  • biedl-bardet syndrome
retinitis pigmentosa
  • retinitis pigmentosa 1
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for EEF1A1

Genetic Association Database (GAD)
EEF1A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EEF1A1
genes like me logo Genes that share disorders with EEF1A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EEF1A1 Gene

Publications for EEF1A1 Gene

  1. Txk, a member of the non-receptor tyrosine kinase of the Tec family, forms a complex with poly(ADP-ribose) polymerase 1 and elongation factor 1alpha and regulates interferon-gamma gene transcription in Th1 cells. (PMID: 17177976) Maruyama T … Suzuki N (Clinical and experimental immunology 2007) 3 4 22 60
  2. Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm. (PMID: 12426392) Bohnsack MT … Görlich D (The EMBO journal 2002) 3 4 22 60
  3. The novel lysine specific methyltransferase METTL21B affects mRNA translation through inducible and dynamic methylation of Lys-165 in human eukaryotic elongation factor 1 alpha (eEF1A). (PMID: 28108655) Małecki J … Falnes PØ (Nucleic acids research 2017) 3 4 60
  4. Novel N-terminal and Lysine Methyltransferases That Target Translation Elongation Factor 1A in Yeast and Human. (PMID: 26545399) Hamey JJ … Wilkins MR (Molecular & cellular proteomics : MCP 2016) 3 4 60
  5. Elongation factor-1A1 is a novel substrate of the protein phosphatase 1-TIMAP complex. (PMID: 26497934) Boratkó A … Csortos C (The international journal of biochemistry & cell biology 2015) 3 4 60

Products for EEF1A1 Gene

Sources for EEF1A1 Gene

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