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EEF1A1 Gene

protein-coding GIFtS: 62

GC06M074282

eukaryotic translation elongation factor 1 alpha 1
(Previous name: leukocyte receptor cluster (LRC) member 7 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: EF1A, EEF1A, LENG7)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CCS-3 ^²
CCS3 ^²
EEF-1 ^²
EEF1A ^², ³
EF-1-alpha-1 ^³
EF-Tu ^², ³
EF1A ^², ³, ⁵
FLJ25721 ^²
GRAF-1EF ^²
HNGC:16303 ^²
LENG7 ^², ³
MGC102687 ^²
MGC131894 ^²
MGC16224 ^²
OTTHUMP00000016736 ^²
OTTHUMP00000063804 ^²
OTTHUMP00000063805 ^²
PTI1 ^²
eEF1A-1 ^², ³

Descriptions
CTCL tumor antigen ^²
EF1a-like protein ^²
Elongation factor 1 A-1 ^³
Elongation factor Tu ^², ³
Leukocyte receptor cluster member 7 ^³
cervical cancer suppressor 3 ^²
elongation factor 1 alpha subunit ^²
elongation factor 1-alpha ^²
eukaryotic translation elongation factor 1 alpha 1 ^²
eukaryotic translation elongation factor 1 alpha 1-like 14 ^²
glucocorticoid receptor AF-1 specific elongation factor ^²
leukocyte receptor cluster (LRC) member 7 ^¹, ²
prostate tumor-inducing protein 1 ^²
translation elongation factor 1 alpha 1-like 14 ^²

External Ids
HGNC: 3189¹
Entrez Gene: 1915²
UniProtKB: P68104³
Ensembl: ENSG00000156508⁷

Search outside databases for aliases for EEF1A1 gene

Previous GC identifers: GC06M074183 GC06M074221 GC06M074222

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for EEF1A1:

This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is

responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1)

is expressed in brain, placenta, lung, liver, kidney, and pancreas, and the other isoform (alpha

2) is expressed in brain, heart and skeletal muscle. This isoform is identified as an autoantigen

in 66% of patients with Felty syndrome. This gene has been found to have multiple copies on many

chromosomes, some of which, if not all, represent different pseudogenes. [provided by RefSeq]

UniProtKB/Swiss-Prot: EF1A1_HUMAN, P68104

Function: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of

ribosomes during protein biosynthesis

Gene Wiki entry for EEF1A1 (Eukaryotic_translation_elongation_factor_1_alpha_1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the EEF1A1 gene

Entrez Gene cytogenetic band: 6q14.1 Ensembl cytogenetic band: 6q13 HGNC cytogenetic band: 6q14.1

EEF1A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M074282: (about GC identifiers)

Start:	74,282,194 bp from pter
End:	74,288,344 bp from pter
Size:	6,151 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000006.10 NT_007299.12

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: EF1A1_HUMAN, P68104 (See protein sequence)

Recommended Name: Elongation factor 1-alpha 1

Size: 462 amino acids; 50141 Da

Subunit: Found in a nuclear export complex with XPO5, EEF1A1, Ran and aminoacylated tRNA. Interacts

with XPO5. May interact with ERGIC2

Subcellular location: Cytoplasm

PDB structures from and Proteopedia :

1SYW (3D)

Secondary accessions: P04719 P04720

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001393.1

ENSEMBL proteins:

ENSP00000359273 ENSP00000350920 ENSP00000339053 ENSP00000339063 ENSP00000330054 ENSP00000348651

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (eEF1A1)
	Human Recombinant Proteins from Abnova (EEF1A1)

OriGene Purified Recombinant Human Protein: EEF1A1

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	TAS	3512269
GO:0005829	cytosol	EXP	10368288
GO:0005853	eukaryotic translation elongation factor 1 complex	TAS	2564392

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Antibodies for EEF1A1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of EEF1A1
	Sigma-Aldrich Antibodies for EEF1A1
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for EEF1A1 (EEF1A)
	Antibodies from Abcam (eEF1A1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (EEF1A1)
	Novus Biologicals Antibody for EEF1A1

Assays for EEF1A1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P68104

ProtoNet protein and cluster: P68104

UniProtKB/Swiss-Prot: EF1A1_HUMAN, P68104

Similarity: Belongs to the GTP-binding elongation factor family. EF-Tu/EF-1A subfamily

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (EEF1A1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001402

Applied Biosystems Silencer® siRNAs for EEF1A1

Sigma-Aldrich siRNA for EEF1A1

Sigma-Aldrich shRNA for EEF1A1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for EEF1A1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001402
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001402
untagged cDNA clones in CMV expression vector (see all 7): NM_001402

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001402

UniProtKB/Swiss-Prot: EF1A1_HUMAN, P68104

Function: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of

ribosomes during protein biosynthesis

Genatlas biochemistry entry for EEF1A1:

eukaryotic translation elongation factor 1,alpha 1,ubiquitously expressed

3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Eef1a1):

lethality-prenatal/perinatal

life span-post-weaning/aging

tumorigenesis

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003746	translation elongation factor activity	IEA	--
GO:0003924	GTPase activity	IEA	--
GO:0005515	protein binding	IPI	15231747 16828757 17373842 18000879
GO:0005525	GTP binding	TAS	3512269

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for EEF1A1

5/478 Interacting proteins for EEF1A1 (ENSP00000330054³ P68104^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 478 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ZBTB16	Q05516¹	STRING (score=.829) EBI-352162, EBI-711925
RPL23	P62829²	STRING (score=.935) MINT-6542674 MINT-6489217 MINT-6489539 MINT-6488590 MINT-6488488 MINT-6488791
RPS3P3	P23396²	STRING (score=.916) MINT-6542674 MINT-6489539 MINT-6488590 MINT-6488488 MINT-6489355 MINT-6488791
RPL11	P62913²	STRING (score=.957) MINT-6542674 MINT-6489539 MINT-6488590 MINT-6489355 MINT-6488791
RPL24P6	P83731²	STRING (score=.899) MINT-6542674 MINT-6489539 MINT-6488590 MINT-6489355 MINT-6488791

About this table

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006414	translational elongation	TAS	8812466

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for EEF1A1
10/34 Novoseek chemical compound relationships for EEF1A1 gene (see all 34 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
aminoacyl-trna	90.58	92	2011527 (3), 12379845 (3), 15680978 (3), 2110000 (3) (see all 45)
gtp	82.85	160	18773979 (4), 2011527 (3), 15952884 (3), 2157708 (3) (see all 77)
gdp	82.56	59	2110000 (3), 8665868 (2), 18773979 (2), 8722020 (2) (see all 38)
ge2270a	79.44	3	8494369 (1), 9209782 (1), 12370016 (1)
pulvomycin	78.54	5	15581367 (3), 9405422 (2)
trna	76.21	37	18336835 (3), 18221514 (2), 16601123 (2), 12354112 (2) (see all 24)
smpb	72.59	9	16601123 (4), 11904186 (1), 11694632 (1), 16381838 (1)
xanthosine 5'-triphosphate	68.32	1	8446899 (1)
anticodon	62.88	7	10397336 (1), 16890341 (1), 11395413 (1), 16601123 (1) (see all 5)
trna(phe)	58.98	3	2190631 (1), 12354112 (1), 10677222 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (EEF1A1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001402

Sigma-Aldrich siRNA for EEF1A1

Sigma-Aldrich shRNA for EEF1A1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001402

REFSEQ mRNAs for EEF1A1 gene:

NM_001402.5

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001402

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001402
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001402
                                 untagged cDNA clones in CMV expression vector (see all 7): NM_001402

Additional cDNA sequence: AK300922.1

24/1155 DOTS entries (see all 1155 ):

DT.100894282 DT.100748056 DT.92071614 DT.92071332 DT.100893975 DT.100770577 DT.100894339 DT.91892031

DT.101962924 DT.100747923 DT.100894535 DT.85101477 DT.100894180 DT.100894204 DT.92342128 DT.91994360

DT.95377109 DT.95377203 DT.95376680 DT.97870655 DT.100894067 DT.100894270 DT.100857960 DT.100894582

24/2606 AceView cDNA sequences (see all 2606 ):

CR621126 BQ020166 CB123716 CB134105 CR626129 CR590677 CR593301 CR601574

BQ316373 CR592337 CR605055 BE156258 CR611142 CR609972 BC063511 CR591440

CR594392 AI905189 CB134168 CR603848 CR605359 CR614121 AI630170 CR593781

highest scoring ESTs for EEF1A1:

AA971886 AK024888 AK026650 AK055058 AK098510 AK098623 AK127384 AW779866 BC008587 BC009875

Unigene Clusters for EEF1A1:

Eukaryotic translation elongation factor 1 alpha 1

Hs.586423 [show with all ESTs], Hs.644639 [show with all ESTs], Hs.713109 [show with all ESTs]

Unigene Representative Sequences: NM_001402, AK292639, AK300922

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for EEF1A1

ExUns:	1	^	2	^	3a	·	3b	^	4	^	5	^	6
SP1:
SP2:
SP3:

About this scheme

ECgene alternative splicing isoforms for EEF1A1

6 Ensembl transcripts including schematic representations:

ENST00000340017 ENST00000358190 ENST00000309268 ENST00000316292 ENST00000331523 ENST00000356303

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

EEF1A1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for EEF1A1

¹ / ² / ³

19 probe-sets matching EEF1A1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
40887_g_at²^{, 3}	U95-A	24	1.00	0.20	0.89	1.06	M29548	0.80	0.65	0.73	1
40886_at²^{, 3}	U95-A	6	1.00	0.19	0.65	0.95	M29548	0.80	0.65	0.73	1
1288_s_at²^{, 3}	U95-A	31	1.00	0.13	0.87	1.07	J04617	0.20	0.12	0.17	1
91422_at²^{, 3}	U95-E	1	0.94	1.00	0.93	0.50	W63684	0.60	1.00	0.82	1
57355_f_at²^{, 3}	U95-C	29	0.88	0.09	0.95	1.19	AI985648	0.40	0.62	0.52	1
60075_f_at²^{, 3}	U95-C	22	0.81	0.12	0.88	1.23	AI653625	0.40	0.67	0.55	1
227708_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AW469790	0.40	1.00	0.76	1
206559_x_at²^{, 3}	U133-A	21	1.00	0.19	--	--	NM_001403	0.20	1.00	0.72	1
204892_x_at²^{, 3}	U133-A	29	1.00	0.14	--	--	NM_001402	0.60	1.00	0.82	1
213477_x_at²^{, 3}	U133-A	26	1.00	0.13	--	--	AL515273	0.20	0.50	0.38	1
213614_x_at²^{, 3}	U133-A	20	0.91	0.18	--	--	BE786672	0.40	0.67	0.55	1
213583_x_at²^{, 3}	U133-A	20	0.91	0.17	--	--	BE964125	0.20	1.00	0.72	1
227708_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
206559_x_at²	U133Plus2	21	1.00	0.19	--	--	--	--	--	--	--
204892_x_at²	U133Plus2	29	1.00	0.14	--	--	--	--	--	--	--
213477_x_at²	U133Plus2	26	1.00	0.13	--	--	--	--	--	--	--
213614_x_at²	U133Plus2	20	0.91	0.18	--	--	--	--	--	--	--
213583_x_at²	U133Plus2	20	0.91	0.17	--	--	--	--	--	--	--
1557120_at*²	U133Plus2	NULL	0.00	0.00	--	--	--	--	--	--	--

GeneDecks EEF1A1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene clusters: Hs.586423 Hs.644639 Hs.713109
Expression variation in blood from EXPOLDB for EEF1A1
UniProtKB/Swiss-Prot: EF1A1_HUMAN, P68104
Tissue specificity: Brain, placenta, lung, liver, kidney, pancreas but barely detectable in heart
and skeletal muscle

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for EEF1A1 gene from 5/16 species (see all 16 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	EEF1A1¹	--	eukaryotic translation elongation factor 1 alpha 1	93.58(n) 99.78(a)	608325 XM_845314.1 XP_850407.1
chimpanzee (Pan troglodytes)	EEF1A1¹	--	eukaryotic translation elongation factor 1 alpha 1	99.86(n) 100(a)	494136 NM_001009165.1 NP_001009165.1
cow (Bos taurus)	EEF1A1¹	--	eukaryotic translation elongation factor 1 alpha 1	91.77(n) 99.78(a)	784131 XM_001249987.1 XP_001249988.1
rat (Rattus norvegicus)	Eef1a2l1¹	--	eukaryotic translation elongation factor 1 alpha 2 more	91.34(n) 99.57(a)	29652 NM_033539.1 NP_284925.1
mouse (Mus musculus)	Eef1a1⁵	9	eukaryotic translation elongation factor 1 alpha 1	--	X13661

About this table Species with no ortholog for EEF1A1

ENSEMBL Gene Tree for EEF1A1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for EEF1A1 gene

EEF1A2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/44 NCBI SNPs in EEF1A1 are shown (see all 44 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 34)

AB	SNP ID	Valid	Chr 6 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1390082^1,2	A,C,F,H,O	74283039(+)	`AAAAAA/TTTTTA`	1	--	ut3¹		5		MN EU EA WA	507
	rs3822960^1,2	A,C,F,H	74287580(-)	`GAGAAG/AGTGGC`	1	--	ng3¹		10		MN EA EU WA	2090
--	rs7751342^1,2	A,C,F,H	74281866(+)	`CAGATT/GAACTG`	1	--	ng5¹		4		EU EA WA	420
	rs3806980^1,2	C,F,H	74287944(-)	`TACACC/TCTAAT`	1	--	ng3¹ ese³		6		MN EA EU WA	1670
	rs9442917^1,2	C,F,H	74283774(+)	`CAAAGC/AAACCC`	1	--	ut3¹ ese³		10		EU EA WA NS	1054
	rs11755449^1,2	C,F,H	74283074(+)	`ATGTCC/TTTTAA`	1	--	ut3¹ ese³		14		EU EA WA NA	1422
--	rs1128073^1,2	C,F	74282966(-)	`tcctcC/Atgggt`	1	--	ut3¹		1		MN	184
	rs16883805^1,2	F,H	74283694(+)	`GCAACA/CCAAGG`	1	--	ut3¹		6		NA EU WA EA	422
--	rs41501347^1,2	F	74283388(-)	`TAGCTA/GTAAAA`	1	--	ut3¹		6		NS	664
	rs3806981^1,2	C	74287853(-)	`CACCCA/CCCCCA`	1	--	ng3¹ ese³		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for EEF1A1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 130590

10/16 Novoseek disease relationships for EEF1A1 gene (see all 16 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
mimicry	42.79	3	12370017 (1), 15317456 (1)
prostate carcinoma	15.29	15	16707856 (4), 8988032 (3), 7542776 (3), 9465091 (1) (see all 5)
sarcoma rous	14.95	2	16099414 (1), 9099894 (1)
shock	6.88	8	12417652 (1), 12641431 (1), 12747404 (1), 15378750 (1) (see all 8)
necrosis	2.89	1	18688046 (1)
vesicular stomatitis	1.18	1	12529558 (1)
tuberculosis	0.00	3	11077990 (3)
cancer	0.00	11	12869201 (3), 9465091 (2), 16689924 (1), 15290352 (1) (see all 7)
carcinoma	0.00	5	7542776 (2), 16707856 (1), 15716006 (1)
tumors	0.00	18	8988032 (2), 10216950 (2), 10572178 (1), 11594566 (1) (see all 10)

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(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/328 PubMed articles for EEF1A1 gene (see all 328 ):

Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm. (PubMed id 12426392)^{1, 3, 4} Bohnsack M.T....Gorlich D. (2002)
Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. (PubMed id 16916647)^{3, 4} Kim S.C.... Zhao Y. (2006)
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{3, 4} Rush J.... Comb M.J. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Exportin-5-mediated nuclear export of eukaryotic elongation factor 1A and tRNA. (PubMed id 12426393)^{3, 4} Calado A.... Kutay U. (2002)
Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster. (PubMed id 10941842)^{2, 3} Wende H....Ziegler A. (2000)
Assignment of human elongation factor 1alpha genes: EEF1A maps to chromosome 6q14 and EEF1A2 to 20q13.3. (PubMed id 8812466)^{2, 3} Lund A....Tommerup N. (1996)
Retropseudogenes constitute the major part of the human elongation factor 1 alpha gene family. (PubMed id 2183196)^{3, 4} Madsen H.O.... Hjorth J.P. (1990)
Murine elongation factor 1 alpha (EF-1 alpha) is posttranslationally modified by novel amide-linked ethanolamine-phosphoglycerol moieties. Addition of ethanolamine-phosphoglycerol to specific glutamic acid residues on EF-1 alpha. (PubMed id 2569467)^{3, 4} Whiteheart S.W.... Hart G.W. (1989)
Isolation and characterization of the human chromosomal gene for polypeptide chain elongation factor-1 alpha. (PubMed id 2564392)^{3, 4} Uetsuki T.... Kaziro Y. (1989)

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Entrez Gene: 1915	HGNC: 3189	AceView: EEF1A1	Ensembl:ENSG00000156508	euGenes: HUgn1915
ECgene: EEF1A1	H-InvDB: EEF1A1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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ATLAS Chromosomes in Cancer entry for EEF1A1	Genetics and Cytogenetics in Oncology and Haematology

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Products for EEF1A1:

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EEF1A1 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for EEF1A1

Summaries
for EEF1A1

Genomic Location
for EEF1A1

Proteins
for EEF1A1

Protein Domains/
Families
for EEF1A1

Gene Function
for EEF1A1

Pathways & Interactions
for EEF1A1

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for EEF1A1

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for EEF1A1

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for EEF1A1

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

EEF1A1 (Gene Symbol)
CCS-3
CCS3
EEF-1
EEF1A
EF-1-alpha-1
EF-Tu
EF1A
FLJ25721
GRAF-1EF
HNGC:16303
LENG7
MGC102687
MGC131894
MGC16224
OTTHUMP00000016736
OTTHUMP00000063804
OTTHUMP00000063805
PTI1
eEF1A-1
CTCL tumor antigen
EF1a-like protein
Elongation factor 1 A-1
Elongation factor Tu
Leukocyte receptor cluster member 7
cervical cancer suppressor 3
elongation factor 1 alpha subunit
elongation factor 1-alpha
eukaryotic translation elongation factor 1 alpha 1
eukaryotic translation elongation factor 1 alpha 1-like 14
glucocorticoid receptor AF-1 specific elongation factor
leukocyte receptor cluster (LRC) member 7
prostate tumor-inducing protein 1
translation elongation factor 1 alpha 1-like 14

EEF1A1 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor EEF1A1

Summariesfor EEF1A1

Genomic Locationfor EEF1A1

Proteinsfor EEF1A1

Protein Domains/Familiesfor EEF1A1

Gene Functionfor EEF1A1

Pathways & Interactionsfor EEF1A1

Drugs & Compoundsfor EEF1A1

Transcriptsfor EEF1A1

Expression for EEF1A1

Orthologsfor EEF1A1

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SNPs/Variantsfor EEF1A1

Disorders & Mutationsfor EEF1A1

Medical Newsfor EEF1A1

Publicationsfor EEF1A1

Search for EEF1A1

Genome Databases showing EEF1A1

Other Databases showing EEF1A1

Specialized Databases showing EEF1A1

Licensable Technologiesfor EEF1A1

Servicesfor EEF1A1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for EEF1A1

Summaries
for EEF1A1

Genomic Location
for EEF1A1

Proteins
for EEF1A1

Protein Domains/
Families
for EEF1A1

Gene Function
for EEF1A1

Pathways & Interactions
for EEF1A1

Drugs & Compounds
for EEF1A1

Transcripts
for EEF1A1

Expression
for EEF1A1

Orthologs
for EEF1A1

Paralogs
for EEF1A1

SNPs/Variants
for EEF1A1

Disorders & Mutations
for EEF1A1

Medical News
for EEF1A1

Publications
for EEF1A1

Licensable Technologies
for EEF1A1

Services
for EEF1A1