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Aliases for EEF1A1 Gene

Aliases for EEF1A1 Gene

  • Eukaryotic Translation Elongation Factor 1 Alpha 1 2 3
  • EF1A 3 4 6
  • Leukocyte Receptor Cluster (LRC) Member 7 2 3
  • Leukocyte Receptor Cluster Member 7 3 4
  • Eukaryotic Elongation Factor 1 A-1 3 4
  • Elongation Factor Tu 3 4
  • EF-1-Alpha-1 3 4
  • EEF1A-1 3 4
  • EEF1A 3 4
  • LENG7 3 4
  • EF-Tu 3 4
  • Eukaryotic Translation Elongation Factor 1 Alpha 1-Like 14 3
  • Glucocorticoid Receptor AF-1 Specific Elongation Factor 3
  • Translation Elongation Factor 1 Alpha 1-Like 14 3
  • Elongation Factor 1 Alpha Subunit 3
  • Prostate Tumor-Inducing Protein 1 3
  • Cervical Cancer Suppressor 3 3
  • Elongation Factor 1-Alpha 1 3
  • CTCL Tumor Antigen 3
  • EF1a-Like Protein 3
  • HNGC:16303 3
  • GRAF-1EF 3
  • CCS-3 3
  • EE1A1 3
  • EEF-1 3
  • CCS3 3
  • PTI1 3

External Ids for EEF1A1 Gene

Previous Symbols for EEF1A1 Gene

  • EF1A
  • EEF1A
  • LENG7

Summaries for EEF1A1 Gene

Entrez Gene Summary for EEF1A1 Gene

  • This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas, and the other isoform (alpha 2) is expressed in brain, heart and skeletal muscle. This isoform is identified as an autoantigen in 66% of patients with Felty syndrome. This gene has been found to have multiple copies on many chromosomes, some of which, if not all, represent different pseudogenes. [provided by RefSeq, Jul 2008]

GeneCards Summary for EEF1A1 Gene

EEF1A1 (Eukaryotic Translation Elongation Factor 1 Alpha 1) is a Protein Coding gene. Diseases associated with EEF1A1 include tinea nigra and feltys syndrome. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Translational Control. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is EEF1A2.

UniProtKB/Swiss-Prot for EEF1A1 Gene

  • This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.

Gene Wiki entry for EEF1A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EEF1A1 Gene

Genomics for EEF1A1 Gene

Genomic Location for EEF1A1 Gene

Start:
73,515,750 bp from pter
End:
73,523,797 bp from pter
Size:
8,048 bases
Orientation:
Minus strand

Genomic View for EEF1A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EEF1A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EEF1A1 Gene

Regulatory Elements for EEF1A1 Gene

Proteins for EEF1A1 Gene

  • Protein details for EEF1A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P68104-EF1A1_HUMAN
    Recommended name:
    Elongation factor 1-alpha 1
    Protein Accession:
    P68104
    Secondary Accessions:
    • P04719
    • P04720
    • Q6IQ15

    Protein attributes for EEF1A1 Gene

    Size:
    462 amino acids
    Molecular mass:
    50141 Da
    Quaternary structure:
    • Found in a nuclear export complex with XPO5, EEF1A1, Ran and aminoacylated tRNA. Interacts with PARP1, TXK, XPO5 and KARS. May interact with ERGIC2. Interacts with IFIT1 (via TPR repeats 4-7) (By similarity). Interacts with DLC1, facilitating distribution to the membrane periphery and ruffles upon growth factor stimulation. Interacts with ZPR1; the interaction occurs in a epidermal growth factor (EGF)-dependent manner.
    SequenceCaution:
    • Sequence=AAA52367.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for EEF1A1 Gene

    Alternative splice isoforms for EEF1A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EEF1A1 Gene

Proteomics data for EEF1A1 Gene at MOPED

Post-translational modifications for EEF1A1 Gene

  • ISGylated.
  • Phosphorylated by TXK. Phosphorylation by PASK increases translation efficiency.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys20, Lys30, Lys41, Lys44, Lys62, Lys146, Lys154, Lys165, Lys172, Lys179, Lys180, Lys212, Lys255, Lys273, Lys318, Lys392, Lys395, Lys408, and Lys439
  • Glycosylation at Asn284

Other Protein References for EEF1A1 Gene

No data available for DME Specific Peptides for EEF1A1 Gene

Domains for EEF1A1 Gene

UniProtKB/Swiss-Prot:

EF1A1_HUMAN
Domain:
  • Contains 1 tr-type G (guanine nucleotide-binding) domain.:
    • P68104
Family:
  • Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.:
    • P68104
genes like me logo Genes that share domains with EEF1A1: view

No data available for Gene Families for EEF1A1 Gene

Function for EEF1A1 Gene

Molecular function for EEF1A1 Gene

GENATLAS Biochemistry: eukaryotic translation elongation factor 1,alpha 1,ubiquitously expressed
UniProtKB/Swiss-Prot Function: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.
UniProtKB/Swiss-Prot Induction: By homocysteine (HC), may mediate accelerated synthesis of free thiol-containing proteins in response to HC-induced oxidative stress.

Gene Ontology (GO) - Molecular Function for EEF1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding IDA 12426392
GO:0003746 translation elongation factor activity TAS 17595531
GO:0003924 GTPase activity IEA --
GO:0005515 protein binding IPI 15161933
GO:0005525 GTP binding TAS 3512269
genes like me logo Genes that share ontologies with EEF1A1: view
genes like me logo Genes that share phenotypes with EEF1A1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for EEF1A1 Gene

Localization for EEF1A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EEF1A1 Gene

Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Colocalizes with DLC1 at actin-rich regions in the cell periphery. Translocates together with ZPR1 from the cytoplasm to the nucleus and nucleolus after treatment with mitogens.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EEF1A1 Gene COMPARTMENTS Subcellular localization image for EEF1A1 gene
Compartment Confidence
nucleus 5
cytosol 4
chloroplast 2
cytoskeleton 2
mitochondrion 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for EEF1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 23580065
GO:0005634 NOT nucleus IDA 12426392
GO:0005730 nucleolus IDA 9852145
GO:0005737 cytoplasm TAS 3512269
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with EEF1A1: view

Pathways for EEF1A1 Gene

genes like me logo Genes that share pathways with EEF1A1: view

Pathways by source for EEF1A1 Gene

1 Cell Signaling Technology pathway for EEF1A1 Gene
2 BioSystems pathways for EEF1A1 Gene

Gene Ontology (GO) - Biological Process for EEF1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006412 translation TAS --
GO:0006414 translational elongation TAS 8812466
genes like me logo Genes that share ontologies with EEF1A1: view

Compounds for EEF1A1 Gene

(4) HMDB Compounds for EEF1A1 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
146-91-8
Guanosine triphosphate
  • 5'-GTP
86-01-1
Phosphate
  • NFB Orthophosphate
14265-44-2
Water
  • Dihydrogen oxide
7732-18-5

(1) Drugbank Compounds for EEF1A1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Guanosine-5'-Diphosphate
146-91-8 target

(59) Novoseek inferred chemical compound relationships for EEF1A1 Gene

Compound -log(P) Hits PubMed IDs
kirromycin 90.6 10
aminoacyl-trna 90.2 60
aurodox 83.6 5
gtp 82.7 113
gdp 82 45
genes like me logo Genes that share compounds with EEF1A1: view

Transcripts for EEF1A1 Gene

Unigene Clusters for EEF1A1 Gene

Eukaryotic translation elongation factor 1 alpha 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EEF1A1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6
SP1:
SP2:
SP3:

Relevant External Links for EEF1A1 Gene

GeneLoc Exon Structure for
EEF1A1
ECgene alternative splicing isoforms for
EEF1A1

Expression for EEF1A1 Gene

mRNA expression in normal human tissues for EEF1A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EEF1A1 Gene

SOURCE GeneReport for Unigene cluster for EEF1A1 Gene Hs.535192

mRNA Expression by UniProt/SwissProt for EEF1A1 Gene

P68104-EF1A1_HUMAN
Tissue specificity: Brain, placenta, lung, liver, kidney, pancreas but barely detectable in heart and skeletal muscle
genes like me logo Genes that share expressions with EEF1A1: view

Orthologs for EEF1A1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EEF1A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EEF1A1 36
  • 99.86 (n)
  • 100 (a)
EEF1A1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EEF1A1 36
  • 91.77 (n)
  • 100 (a)
EEF1A1 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EEF1A1 37
  • 100 (a)
OneToOne
LOC102151992 36
  • 92.57 (n)
  • 96.75 (a)
mouse
(Mus musculus)
Mammalia Eef1a1 36
  • 91.85 (n)
  • 99.78 (a)
Eef1a1 16
Eef1a1 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 100 (a)
OneToMany
-- 37
  • 54 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia EEF1A1 37
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eef1a1 36
  • 91.63 (n)
  • 99.78 (a)
chicken
(Gallus gallus)
Aves EEF1A 37
  • 99 (a)
OneToOne
EEF1A1 36
  • 86.29 (n)
  • 99.13 (a)
lizard
(Anolis carolinensis)
Reptilia EEF1A1 37
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eef1a1o 36
  • 78.26 (n)
  • 91.52 (a)
MGC75658 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1771 36
zebrafish
(Danio rerio)
Actinopterygii -- 36
eef1a1a 36
  • 81.46 (n)
  • 94.81 (a)
eef1a1a 37
  • 95 (a)
OneToMany
eef1a1b 37
  • 94 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Ef1alpha100E 37
  • 85 (a)
ManyToMany
Ef1alpha48D 38
  • 85 (a)
Ef1alpha100E 38
  • 84 (a)
worm
(Caenorhabditis elegans)
Secernentea eef-1A.1 37
  • 83 (a)
ManyToMany
eef-1A.2 37
  • 83 (a)
ManyToMany
eft-3 38
  • 83 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TEF1 39
TEF1 39
TEF2 37
  • 81 (a)
OneToMany
soybean
(Glycine max)
eudicotyledons Gma.10761 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G07940 36
  • 71.99 (n)
  • 77.98 (a)
rice
(Oryza sativa)
Liliopsida Os03g0177500 36
  • 71.66 (n)
  • 79.19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 78 (a)
ManyToMany
CSA.11100 37
  • 84 (a)
ManyToMany
CSA.11147 37
  • 37 (a)
ManyToMany
CSA.4537 37
  • 82 (a)
ManyToMany
Species with no ortholog for EEF1A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EEF1A1 Gene

ENSEMBL:
Gene Tree for EEF1A1 (if available)
TreeFam:
Gene Tree for EEF1A1 (if available)

Paralogs for EEF1A1 Gene

Paralogs for EEF1A1 Gene

genes like me logo Genes that share paralogs with EEF1A1: view

Variants for EEF1A1 Gene

Sequence variations from dbSNP and Humsavar for EEF1A1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1128073 -- 73,516,522(-) TCCTC(A/C)TGGGT utr-variant-3-prime
rs1390082 -- 73,516,595(+) AAAAA(A/T)TTTTA utr-variant-3-prime
rs1874229 -- 73,518,283(+) TTTGC(A/G)TTCAG intron-variant
rs1874230 -- 73,518,326(+) CTGCA(A/G)TAAGT intron-variant
rs2073465 -- 73,520,069(-) TTTTT(C/T)CTTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EEF1A1 Gene

Variant ID Type Subtype PubMed ID
nsv886158 CNV Gain 21882294
nsv5350 CNV Loss 18451855
nsv886159 CNV Loss 21882294
esv2675873 CNV Deletion 23128226
nsv463153 CNV Loss 19166990

Relevant External Links for EEF1A1 Gene

HapMap Linkage Disequilibrium report
EEF1A1

Disorders for EEF1A1 Gene

(2) MalaCards Diseases for EEF1A1 Gene

Search for EEF1A1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for EEF1A1 Gene

(17) Novoseek inferred disease relationships for EEF1A1 Gene

Disease -log(P) Hits PubMed IDs
mimicry 40.5 2
sarcoma rous 13.5 2
prostate carcinoma 13.3 12
shock 12.7 11
necrosis 4.02 2

Relevant External Links for EEF1A1

Genetic Association Database (GAD)
EEF1A1
genes like me logo Genes that share disorders with EEF1A1: view

No data available for UniProtKB/Swiss-Prot for EEF1A1 Gene

Publications for EEF1A1 Gene

  1. Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm. (PMID: 12426392) Bohnsack M.T. … Goerlich D. (EMBO J. 2002) 3 4 23
  2. Txk, a member of the non-receptor tyrosine kinase of the Tec family, forms a complex with poly(ADP-ribose) polymerase 1 and elongation factor 1alpha and regulates interferon-gamma gene transcription in Th1 cells. (PMID: 17177976) Maruyama T. … Suzuki N. (Clin. Exp. Immunol. 2007) 3 4 23
  3. Interaction of G-rich GT oligonucleotides with nuclear-associated eEF1A is correlated with their antiproliferative effect in haematopoietic human cancer cell lines. (PMID: 16689924) Scaggiante B. … Manzini G. (FEBS J. 2006) 3 23
  4. Mitochondrial translation: elongation factor tu is essential in fission yeast and depends on an exchange factor conserved in humans but not in budding yeast. (PMID: 15695360) Chiron S. … Bonnefoy N. (Genetics 2005) 3 23
  5. Deconstructing PTI-1: PTI-1 is a truncated, but not mutated, form of translation elongatin factor 1A1, eEF1A1. (PMID: 15716006) Mansilla F. … Knudsen C.R. (Biochim. Biophys. Acta 2005) 3 23

Products for EEF1A1 Gene

Sources for EEF1A1 Gene

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