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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

EEF1A1 Gene

protein-coding GIFtS: 64
GCID: GC06M074225

eukaryotic translation elongation factor 1 alpha 1

(Previous name: leukocyte receptor cluster (LRC) member 7 )
(Previous symbols: EF1A, EEF1A, LENG7)

Explore 39 diseases affiliated with
EEF1A1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Eukaryotic Translation Elongation Factor 1 Alpha 1¹ ²		EEF-1²
EF1A¹ ² ³ ⁵		GRAF-1EF²
EEF1A¹ ² ³		HNGC:16303²
LENG7¹ ² ³		PTI1²
EE1A1¹ ²		Cervical Cancer Suppressor 3²
Leukocyte Receptor Cluster (LRC) Member 7¹ ²		CTCL Tumor Antigen²
Elongation Factor Tu² ³		EF1a-Like Protein²
Eukaryotic Elongation Factor 1 A-1² ³		Elongation Factor 1 Alpha Subunit²
Leukocyte Receptor Cluster Member 7² ³		Elongation Factor 1-Alpha 1²
EF-1-Alpha-1¹		Eukaryotic Translation Elongation Factor 1 Alpha 1-Like 14²
EF-Tu² ³		Glucocorticoid Receptor AF-1 Specific Elongation Factor²
EEF1A-1¹		Prostate Tumor-Inducing Protein 1²
CCS-3²		Translation Elongation Factor 1 Alpha 1-Like 14²
CCS3²

External Ids:	HGNC: 3189¹	Entrez Gene: 1915²	Ensembl: ENSG00000156508⁷	OMIM: 130590⁵	UniProtKB: P68104³

Export aliases for EEF1A1 gene to outside databases

Previous GC identifers: GC06M074183 GC06M074221 GC06M074222 GC06M074282

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for EEF1A1:

This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the

enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed in brain, placenta, lung,

liver, kidney, and pancreas, and the other isoform (alpha 2) is expressed in brain, heart and skeletal muscle. This

isoform is identified as an autoantigen in 66% of patients with Felty syndrome. This gene has been found to have

multiple copies on many chromosomes, some of which, if not all, represent different pseudogenes. (provided by RefSeq,

Jul 2008)

UniProtKB/Swiss-Prot: EF1A1_HUMAN, P68104

Function: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein

biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor

and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1

cytokine production

Gene Wiki entry for EEF1A1 (Eukaryotic translation elongation factor 1 alpha 1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_007299.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the EEF1A1 gene promoter:
SRF NF-1 SRF (504 AA) Pax-2 Pax-2a Tal-1beta HSF2 ITF-2 Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): EEF1A1 promoter sequence

Search SABiosciences Chromatin IP Primers for EEF1A1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EEF1A1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q14.1 Ensembl cytogenetic band: 6q13 HGNC cytogenetic band: 6q14.1

EEF1A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EEF1A1 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M074225: view genomic region (about GC identifiers)

Start:	74,225,473 bp from pter	End:	74,233,520 bp from pter
Size:	8,048 bases	Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 22,568,782-22,602,772

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: EF1A1_HUMAN, P68104 (See protein sequence)

Recommended Name: Elongation factor 1-alpha 1

Size: 462 amino acids; 50141 Da

Subunit: Found in a nuclear export complex with XPO5, EEF1A1, Ran and aminoacylated tRNA. Interacts with PARP1, TXK,

XPO5 and KARS. May interact with ERGIC2. Interacts with IFIT1 (via TPR repeats 4-7) (By similarity). Interacts with

DLC1, facilitating distribution to the membrane periphery and ruffles upon growth factor stimulation

Subcellular location: Cytoplasm. Nucleus. Note=Colocalizes with DLC1 at actin-rich regions in the cell periphery

Sequence caution: Sequence=AAA52367.1; Type=Erroneous initiation;

1 PDB 3D structure from and Proteopedia for EEF1A1:

1SYW (3D)

Secondary accessions: P04719 P04720

Explore the universe of human proteins at neXtProt for EEF1A1: NX_P68104

Post-translational modifications:

ISGylated¹

Phosphorylated by TXK. Phosphorylation by PASK increases translation efficiency¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P68104

EEF1A1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001393.1

ENSEMBL proteins:

ENSP00000339063 ENSP00000339053 ENSP00000330054 ENSP00000348651 ENSP00000392366

Reactome Protein details: P68104
Human Recombinant Protein Products:

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	Novus Biologicals EEF1A1 Proteins Novus Biologicals EEF1A1 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	TAS	3512269
GO:0005829	cytosol	TAS	--
GO:0005853	eukaryotic translation elongation factor 1 complex	TAS	2564392

EEF1A1 for ontologies About GeneDecksing

EEF1A1 Antibody Products:

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	ThermoFisher Antibody for EEF1A1

Assay Products for EEF1A1:

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	GenScript Custom Assay Services for EEF1A1
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

EEF1A1 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR009001 Transl_elong_EF1A/Init_IF2_C

IPR000795 EF_GTP-bd_dom

IPR004160 Transl_elong_EFTu/EF1A_C

IPR004161 Transl_elong_EFTu/EF1A_2

IPR004539 Transl_elong_EF1A_euk/arc

Graphical View of Domain Structure for InterPro Entry P68104

ProtoNet protein and cluster: P68104

UniProtKB/Swiss-Prot: EF1A1_HUMAN, P68104

Similarity: Belongs to the GTP-binding elongation factor family. EF-Tu/EF-1A subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: EF1A1_HUMAN, P68104

Function: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein

biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor

and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1

cytokine production

Induction: By homocysteine (HC), may mediate accelerated synthesis of free thiol-containing proteins in response to

HC-induced oxidative stress

Genatlas biochemistry entry for EEF1A1:

eukaryotic translation elongation factor 1,alpha 1,ubiquitously expressed

miRNA Products:		OriGene 3'-UTR Clone: EEF1A1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EEF1A1
		8/42 QIAGEN miScript miRNA Assays for microRNAs that regulate EEF1A1 (see all 42):
		hsa-miR-548k hsa-miR-371-5p hsa-miR-133a hsa-miR-3613-3p hsa-miR-29a* hsa-miR-548am hsa-miR-1237 hsa-miR-548e

		SwitchGear 3'UTR luciferase reporter plasmid: EEF1A1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EEF1A1 (see all 7) OriGene shRNA RFP: EEF1A1 OriGene siRNA: EEF1A1
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Gene Editing
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DNA2.0 Custom Protein Engineering Service for EEF1A1

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		GenScript: all cDNA clones in your preferred vector: EEF1A1 (NM_001402)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for EEF1A1
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EEF1A1

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003746	translation elongation factor activity	TAS	17595531
GO:0003924	GTPase activity	IEA	--
GO:0005515	protein binding	IPI	18000879
GO:0005525	GTP binding	TAS	3512269
GO:0019901	protein kinase binding	IPI	17595531

EEF1A1 for ontologies About GeneDecksing

6 GenomeRNAi human phenotypes for EEF1A1:

Decreased influenza A H1N1 (A/	Decreased influenza A/WSN/33 r	Decreased melanin production	Increased G1 DNA content
Increased cell death in HCC-19	Synthetic lethal with Ras

Animal Models:
2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Eef1a1):

mortality/aging

tumorigenesis

EEF1A1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Synthesis of PB1-F2

	Peptide chain elongation	0.98			Translation	0.57
	Eukaryotic Translation Elongation	0.94

Translation Factors

Translation Factors

1.00

EGFR1 Signaling Pathway

EGFR1 Signaling Pathway

1.00

RNA transport

RNA transport

1.00

Translational Control

Translational Control

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Cell Signaling Technology (CST) Pathway for EEF1A1

Translational Control

2 BioSystems Pathways for EEF1A1

	Translation Factors
	EGFR1 Signaling Pathway

5 Reactome Pathways for EEF1A1

	Peptide chain elongation
	Translation
	Eukaryotic Translation Elongation
	Metabolism of proteins
	Gene Expression

1 Kegg Pathway (Kegg details for EEF1A1):

RNA transport

EEF1A1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for EEF1A1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/1514 Interacting proteins for EEF1A1 (P68104^{1, 2, 3} ENSP00000330054⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 1514)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ILF2	Q12905², ENSP00000355011⁴	MINT-6489539 MINT-6488590 MINT-7947479 MINT-6488791 MINT-7945693 MINT-6489355 MINT-8076347 MINT-8076071 MINT-8076236 STRING: ENSP00000355011
RUVBL2	Q9Y230²^,³	MINT-6489217 MINT-7947479 MINT-7945693 MINT-6489355 MINT-6488488 MINT-8076347 MINT-8076071 MINT-8076236 I2D: score=1
SF3B3	Q15393²^,³	MINT-6489539 MINT-6488590 MINT-7947479 MINT-6488791 MINT-6542674 MINT-7945693 MINT-6489355 I2D: score=1
RPS15A	P62244²^,³, ENSP00000318646⁴	MINT-6489539 MINT-6488590 MINT-6488791 MINT-6542674 MINT-6489355 I2D: score=3 STRING: ENSP00000318646
RPL23	P62829²^,³	MINT-6489217 MINT-6489539 MINT-6488590 MINT-6488791 MINT-6542674 MINT-6488488 I2D: score=1

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0006412	translation	TAS	--
GO:0006414	translational elongation	TAS	--
GO:0010467	gene expression	TAS	--

EEF1A1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

EEF1A1 for compounds About GeneDecksing

EMD Millipore small molecules for EEF1A1:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for EEF1A1

4 HMDB Compounds for EEF1A1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine diphosphate	5'-GDP (see all 10)	146-91-8	--
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--
Phosphate	NFB Orthophosphate (see all 13)	14265-44-2	--
Water	Dihydrogen oxide (see all 2)	7732-18-5	--

1 DrugBank Compound for EEF1A1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Guanosine-5'-Diphosphate	--	146-91-8	target	--	10592235

10/59 Novoseek chemical compound relationships for EEF1A1 gene (see all 59) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
kirromycin	90.6	12	9405422 (2), 12370016 (1), 2207147 (1), 10588048 (1) (see all 9)
aminoacyl-trna	90.2	99	19833920 (5), 2011527 (3), 12379845 (3), 2110000 (3) (see all 46)
aurodox	83.6	8	2110000 (3), 12370016 (1), 7851417 (1)
gtp	82.7	165	18773979 (4), 2011527 (3), 15952884 (3), 2157708 (3) (see all 79)
gdp	82	59	2110000 (3), 8665868 (2), 18773979 (2), 8722020 (2) (see all 38)
ge2270a	78.5	3	8494369 (1), 9209782 (1), 12370016 (1)
pulvomycin	77.4	5	15581367 (3), 9405422 (2)
trna	76.4	42	18336835 (3), 18221514 (2), 15952884 (2), 12354112 (2) (see all 27)
smpb	74.5	9	16601123 (4), 11904186 (1), 11694632 (1), 16381838 (1)
xanthosine 5'-triphosphate	67.5	1	8446899 (1)

Search CenterWatch for drugs/clinical trials and news about EEF1A1 / EF1A1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for EEF1A1 gene (2 alternative transcripts):

NM_001402.5 NM_001403.1

Unigene Clusters for EEF1A1:

Eukaryotic translation elongation factor 1 alpha 1

Hs.535192 [show with all ESTs], Hs.586423 [show with all ESTs], Hs.695681 [show with all ESTs]

Unigene Representative Sequences: NM_001402, BM456727, BC001412

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000316292(uc003phi.3 uc003phj.3 uc021zbs.1) ENST00000491404

ENST00000309268(uc003phl.3 uc003phm.1) ENST00000490569 ENST00000331523

ENST00000495333 ENST00000488500 ENST00000356303 ENST00000455918

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EEF1A1
		8/42 QIAGEN miScript miRNA Assays for microRNAs that regulate EEF1A1 (see all 42):
		hsa-miR-548k hsa-miR-371-5p hsa-miR-133a hsa-miR-3613-3p hsa-miR-29a* hsa-miR-548am hsa-miR-1237 hsa-miR-548e

		SwitchGear 3'UTR luciferase reporter plasmid: EEF1A1 3' UTR sequence

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EEF1A1

Additional cDNA sequence:

AF328730.1 AK024888.1 AK026650.1 AK222515.1 AK222519.1 AK222523.1 AK222551.1 AK222982.1

AK223030.1 AK223042.1 AK223046.1 AK289442.1 AK292639.1 AK315827.1 BC001412.1 BC002845.1

BC006102.1 BC008587.1 BC009733.1 BC009875.2 BC010735.1 BC012509.1 BC012891.1 BC014224.2

BC014377.1 BC014892.1 BC018150.1 BC018641.2 BC018850.2 BC019050.2 BC020477.2 BC021686.1

BC022412.1 BC028674.1 BC029337.1 BC029343.1 BC029997.1 BC035877.1 BC038339.1 BC057391.1

BC063511.1 BC065761.1 BC066893.1 BC066894.1 BC070131.1 BC071727.1 BC071741.1 BC071841.1

BC072385.1 BC082268.1 BC111051.1 EF219140.1 EF362804.1

24/1189 DOTS entries (see all 1189):

DT.100894282 DT.100748056 DT.92071614 DT.92071332 DT.100893975 DT.100770577 DT.91892031 DT.100894339

DT.101962924 DT.100894535 DT.100747923 DT.85101477 DT.100894180 DT.100894204 DT.91994360 DT.92342128

DT.95377109 DT.95377203 DT.97870655 DT.100894067 DT.95376680 DT.100857960 DT.100894582 DT.100894270

24/2606 AceView cDNA sequences (see all 2606):

BM755336 CR593333 CR621257 AV647849 CR593922 CR622852 CR623011 CR624727

CR594936 CR598785 CR594494 CR622149 CR616796 CR607663 CR595803 R80556

CR591427 CR607177 CR624776 CR610117 CR590659 CR606446 CR602664 CR594756

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for EEF1A1 About this scheme

ExUns:	1	^	2	^	3a	·	3b	^	4	^	5	^	6
SP1:
SP2:
SP3:

ECgene alternative splicing isoforms for EEF1A1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

EEF1A1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTGTTGAGA

About this image

EEF1A1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Endoderm-like cells (Generation of hepato...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See EEF1A1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for EEF1A1

SOURCE GeneReport for Unigene clusters: Hs.535192 Hs.586423 Hs.695681

UniProtKB/Swiss-Prot: EF1A1_HUMAN, P68104

Tissue specificity: Brain, placenta, lung, liver, kidney, pancreas but barely detectable in heart and skeletal muscle

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for EEF1A1 gene from 10/39 species (see all 39) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	EEF1A1¹	eukaryotic translation elongation factor 1 alpha 1	86.29(n) 99.13(a)		373963 NM_204157.2 NP_989488.2
lizard (Anolis carolinensis)	Reptilia	EEF1A1⁶	--	99(a)	1 ↔ 1	GL343341.1(112759-116458)
African clawed frog (Xenopus laevis)	Amphibia	BC041196.1²	--	85.88(n)		BC041196.1
zebrafish (Danio rerio)	Actinopterygii	BC060907.1²	--	84.65(n)		336334 BC060907.1
fruit fly (Drosophila melanogaster)	Insecta	Ef1alpha48D^{1 , 3}	translational elongation translation elongation more³ Elongation factor 1alpha48D¹	85(a) (best of 2)³ 75.47(n)¹ 85.71(a)¹		48D1³ 36271¹ NM_058027.4¹ NP_477375.1¹
worm (Caenorhabditis elegans)	Secernentea	eft-3³ eef-1A.1¹	Elongation factor 1-alpha³ Protein EEF-1A.1¹	83(a)³ 71(n)¹ 83.55(a)¹		III(7041894-7043435)³ 175975¹ NM_066119.5¹ NP_498520.1¹
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	TEF1(YPR080W)⁴ TEF1¹	Translational elongation factor EF-1 alpha; also encoded more⁴ Tef1p¹	71.19(n)¹ 81.18(a)¹		16(700594-701970)⁴ 856195^{1, 4} NP_015405.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	AT1G07930⁶ AT1G07940⁶ (see all 4)	Elongation factor 1-alpha (see all 4)	77(a) 77(a) (see all 4)	many ↔ many many ↔ many (see all 4)	1(2458244-2460790) 1(2462953-2465504)
rice (Oryza sativa)	Liliopsida	-- -- (see all 4)	elongation factor Tu, putative, expressed (see all 4)	79(a) 79(a) (see all 4)	many ↔ many many ↔ many (see all 4)	3(4099737-4101675) 3(4116595-4118531)
E. coli (Escherichia coli)	Gamma proteobacteria	cysN⁶	sulfate adenylyltransferase, subunit 1	23(a)	1 → many	Chromosome(2872014-2873441)

ENSEMBL Gene Tree for EEF1A1 (if available)
TreeFam Gene Tree for EEF1A1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for EEF1A1 gene

GTPBP2² EEF1A2² GTPBP1²

12 SIMAP similar genes for EEF1A1 using alignment to 13 protein entries: EF1A1_HUMAN (see all proteins):

EEF1A1P5 EEF1A1L14 PTI-1 EEF1A2 EEF1A HBS1L

GSPT1 GSPT2 GFM1 GFM2 GUF1 DKFZp434G247

EEF1A1 for paralogs About GeneDecksing

5/34 Pseudogenes.org Pseudogenes for EEF1A1 (see all 34)
PGOHUM00000238385 PGOHUM00000242326 PGOHUM00000239553 PGOHUM00000239691 PGOHUM00000239752

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs12111143^1,2	C,	--	74224991(+)	`GTCAGT/CGTAAA`	1	--	ds500¹		4		NA WA EA	242
rs182025032^1,2		--	74225103(+)	`CTGCCA/GAGGCC`	1	--	ds500¹		0	--	--	--	--
rs150922924^1,2		--	74225131(+)	`TAAAAA/GATAAA`	1	--	ds500¹		0	--	--	--	--
rs7751342^1,2	C,F,A,H,	--	74225145(+)	`CAGATT/GAACTG`	1	--	ds500¹		22		NS EA NA WA CSA	2348
rs139475137^1,2		--	74225152(+)	`ACTGGG/TAAAGA`	1	--	ds500¹		0	--	--	--	--
rs116914658^1,2	C,F,	--	74225169(+)	`ACAGGC/AAGATC`	1	--	ds500¹		1		EA	120
rs185406225^1,2		--	74225186(+)	`GCCCAA/GGAGTT`	1	--	ds500¹		0	--	--	--	--
rs189029604^1,2		--	74225230(+)	`TTAGCC/GAGGCG`	1	--	ds500¹		0	--	--	--	--
rs149733797^1,2		--	74225235(+)	`CAGGCA/GTGGTG`	1	--	ds500¹		0	--	--	--	--
rs3757113^1,2	C,F,H,	--	74225333(+)	`CAGGGC/AAGGAG`	1	--	ds500¹		7		NS EA	862

HapMap Linkage Disequilibrium report for EEF1A1 (74225473 - 74233520 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for EEF1A1: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

EEF1A1 for disorders           About GeneDecksing

OMIM gene information: 130590    OMIM disorders: --

20/39 diseases for EEF1A1 (see all 39):    About MalaCards

felty's syndrome cervical cancer tinea nigra bardet-biedl syndrome

cervicitis prostatitis treacher collins syndrome nonalcoholic steatohepatitis

severe acute respiratory syndrome cutaneous anthrax esophageal squamous cell carcinoma squamous cell carcinoma

retinitis pigmentosa stomatitis herpes simplex cutaneous t cell lymphoma

colon carcinoma hepatocellular carcinoma carcinoma huntington's disease

1 disease from the University of Copenhagen DISEASES database for EEF1A1:

Tinea nigra

10/17 Novoseek disease relationships for EEF1A1 gene (see all 17) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
mimicry	40.5	3	12370017 (1), 15317456 (1)
sarcoma rous	13.5	2	16099414 (1), 9099894 (1)
prostate carcinoma	13.3	15	16707856 (4), 8988032 (3), 7542776 (3), 9465091 (1) (see all 5)
shock	12.7	12	12417652 (1), 19523215 (1), 12641431 (1), 12747404 (1) (see all 11)
necrosis	4.02	2	18688046 (1), 19856081 (1)
leukemia	0	3	16099414 (1), 18388914 (1), 17609656 (1), 11082319 (1)
vesicular stomatitis	0	1	12529558 (1)
hepatocellular carcinoma	0	1	17825975 (1)
colon carcinoma	0	2	8988032 (1), 10216286 (1)
benign prostatic hyperplasia	0	3	16707856 (1), 8988032 (1), 7542776 (1)

Export disorders for EEF1A1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for EEF1A1 gene, integrated from 9 sources (see all 455):
(articles sorted by number of sources associating them with EEF1A1)

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Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm. (PubMed id 12426392)^{1, 2, 9} Bohnsack M.T.... Goerlich D. (2002)
Phosphorylation of eEF1A1 at Ser300 by TI^R-I results in inhibition of mRNA translation. (PubMed id 20832312)^{1, 2} Lin K.W....Souchelnytskyi S. (2010)
The SAM domain of the RhoGAP DLC1 binds EF1A1 to regulate cell migration. (PubMed id 19158340)^{1, 2} Zhong D....Low B.C. (2009)
Male germ cell expression of the PAS domain kinase PA SKIN and its novel target eukaryotic translation elongation factor eEF1A1. (PubMed id 17595531)^{1, 2} Eckhardt K....Wenger R.H. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Exportin-5-mediated nuclear export of eukaryotic elongation factor 1A and tRNA. (PubMed id 12426393)^{1, 2} Calado A.... Kutay U. (2002)
Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster. (PubMed id 10941842)^{1, 3} Wende H.... Ziegler A. (2000)
Assignment of human elongation factor 1alpha genes: EEF1A maps to chromosome 6q14 and EEF1A2 to 20q13.3. (PubMed id 8812466)^{1, 3} Lund A....Tommerup N. (1996)
Retropseudogenes constitute the major part of the human elongation factor 1 alpha gene family. (PubMed id 2183196)^{1, 2} Madsen H.O.... Hjorth J.P. (1990)
Murine elongation factor 1 alpha (EF-1 alpha) is posttranslationally modified by novel amide-linked ethanolamine-phosphoglycerol moieties. Addition of ethanolamine-phosphoglycerol to specific glutamic acid residues on EF-1 alpha. (PubMed id 2569467)^{1, 2} Whiteheart S.W.... Hart G.W. (1989)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1915	HGNC: 3189	AceView: EEF1A1	Ensembl:ENSG00000156508	euGenes: HUgn1915
ECgene: EEF1A1	Kegg: 1915	H-InvDB: EEF1A1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for EEF1A1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for EEF1A1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for EEF1A1 gene
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Patent Information for EEF1A1 gene:
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EEF1A1 Gene

eukaryotic translation elongation factor 1 alpha 1

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EEF1A1 (Gene Symbol)
Eukaryotic Translation Elongation Factor 1 Alpha 1
EF1A
EEF1A
LENG7
EE1A1
Leukocyte Receptor Cluster (LRC) Member 7
Elongation Factor Tu
Eukaryotic Elongation Factor 1 A-1
Leukocyte Receptor Cluster Member 7
EF-1-Alpha-1
EF-Tu
EEF1A-1
CCS-3
CCS3
EEF-1
GRAF-1EF
HNGC:16303
PTI1
Cervical Cancer Suppressor 3
CTCL Tumor Antigen
EF1a-Like Protein
Elongation Factor 1 Alpha Subunit
Elongation Factor 1-Alpha 1
Eukaryotic Translation Elongation Factor 1 Alpha 1-Like 14
Glucocorticoid Receptor AF-1 Specific Elongation Factor
Prostate Tumor-Inducing Protein 1
Translation Elongation Factor 1 Alpha 1-Like 14

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EEF1A1 Gene

eukaryotic translation elongation factor 1 alpha 1

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