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Aliases for EEF1A1 Gene

Aliases for EEF1A1 Gene

  • Eukaryotic Translation Elongation Factor 1 Alpha 1 2 3 5
  • Leukocyte Receptor Cluster (LRC) Member 7 2 3
  • Leukocyte Receptor Cluster Member 7 3 4
  • Eukaryotic Elongation Factor 1 A-1 3 4
  • Elongation Factor Tu 3 4
  • EF-1-Alpha-1 3 4
  • EEF1A-1 3 4
  • EEF1A 3 4
  • LENG7 3 4
  • EF-Tu 3 4
  • EF1A 3 4
  • Eukaryotic Translation Elongation Factor 1 Alpha 1-Like 14 3
  • Glucocorticoid Receptor AF-1 Specific Elongation Factor 3
  • Translation Elongation Factor 1 Alpha 1-Like 14 3
  • Elongation Factor 1 Alpha Subunit 3
  • Prostate Tumor-Inducing Protein 1 3
  • Cervical Cancer Suppressor 3 3
  • CTCL Tumor Antigen 3
  • EF1a-Like Protein 3
  • HNGC:16303 3
  • GRAF-1EF 3
  • CCS-3 3
  • EE1A1 3
  • EEF-1 3
  • CCS3 3
  • PTI1 3

External Ids for EEF1A1 Gene

Previous HGNC Symbols for EEF1A1 Gene

  • EF1A
  • EEF1A
  • LENG7

Previous GeneCards Identifiers for EEF1A1 Gene

  • GC06M074183
  • GC06M074221
  • GC06M074222
  • GC06M074282
  • GC06M074225

Summaries for EEF1A1 Gene

Entrez Gene Summary for EEF1A1 Gene

  • This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas, and the other isoform (alpha 2) is expressed in brain, heart and skeletal muscle. This isoform is identified as an autoantigen in 66% of patients with Felty syndrome. This gene has been found to have multiple copies on many chromosomes, some of which, if not all, represent different pseudogenes. [provided by RefSeq, Jul 2008]

GeneCards Summary for EEF1A1 Gene

EEF1A1 (Eukaryotic Translation Elongation Factor 1 Alpha 1) is a Protein Coding gene. Diseases associated with EEF1A1 include Tinea Nigra and Cutaneous Anthrax. Among its related pathways are Gene Expression and Viral mRNA Translation. GO annotations related to this gene include poly(A) RNA binding and protein kinase binding. An important paralog of this gene is EEF1A2.

UniProtKB/Swiss-Prot for EEF1A1 Gene

  • This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.

Gene Wiki entry for EEF1A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EEF1A1 Gene

Genomics for EEF1A1 Gene

Regulatory Elements for EEF1A1 Gene

Enhancers for EEF1A1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around EEF1A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for EEF1A1 Gene

Chromosome:
6
Start:
73,515,750 bp from pter
End:
73,523,797 bp from pter
Size:
8,048 bases
Orientation:
Minus strand

Genomic View for EEF1A1 Gene

Genes around EEF1A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EEF1A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EEF1A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EEF1A1 Gene

Proteins for EEF1A1 Gene

  • Protein details for EEF1A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P68104-EF1A1_HUMAN
    Recommended name:
    Elongation factor 1-alpha 1
    Protein Accession:
    P68104
    Secondary Accessions:
    • P04719
    • P04720
    • Q6IQ15

    Protein attributes for EEF1A1 Gene

    Size:
    462 amino acids
    Molecular mass:
    50141 Da
    Quaternary structure:
    • Found in a nuclear export complex with XPO5, EEF1A1, Ran and aminoacylated tRNA. Interacts with PARP1, TXK, XPO5 and KARS. May interact with ERGIC2. Interacts with IFIT1 (via TPR repeats 4-7) (By similarity). Interacts with DLC1, facilitating distribution to the membrane periphery and ruffles upon growth factor stimulation. Interacts with ZPR1; the interaction occurs in a epidermal growth factor (EGF)-dependent manner.
    SequenceCaution:
    • Sequence=AAA52367.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for EEF1A1 Gene

    Alternative splice isoforms for EEF1A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EEF1A1 Gene

Proteomics data for EEF1A1 Gene at MOPED

Post-translational modifications for EEF1A1 Gene

Other Protein References for EEF1A1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for EEF1A1 (EEF1A1)

No data available for DME Specific Peptides for EEF1A1 Gene

Domains & Families for EEF1A1 Gene

Graphical View of Domain Structure for InterPro Entry

P68104

UniProtKB/Swiss-Prot:

EF1A1_HUMAN :
  • Contains 1 tr-type G (guanine nucleotide-binding) domain.
  • Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
Domain:
  • Contains 1 tr-type G (guanine nucleotide-binding) domain.
Family:
  • Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
genes like me logo Genes that share domains with EEF1A1: view

No data available for Gene Families for EEF1A1 Gene

Function for EEF1A1 Gene

Molecular function for EEF1A1 Gene

GENATLAS Biochemistry:
eukaryotic translation elongation factor 1,alpha 1,ubiquitously expressed
UniProtKB/Swiss-Prot Function:
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.
UniProtKB/Swiss-Prot Induction:
By homocysteine (HC), may mediate accelerated synthesis of free thiol-containing proteins in response to HC-induced oxidative stress.

Gene Ontology (GO) - Molecular Function for EEF1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding IDA 12426392
GO:0003746 translation elongation factor activity IEA,TAS 17595531
GO:0005515 protein binding IPI 9852145
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with EEF1A1: view
genes like me logo Genes that share phenotypes with EEF1A1: view

Animal Model Products

miRNA for EEF1A1 Gene

miRTarBase miRNAs that target EEF1A1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EEF1A1 Gene

Localization for EEF1A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EEF1A1 Gene

Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Colocalizes with DLC1 at actin-rich regions in the cell periphery. Translocates together with ZPR1 from the cytoplasm to the nucleus and nucleolus after treatment with mitogens.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EEF1A1 Gene COMPARTMENTS Subcellular localization image for EEF1A1 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
nucleus 5
plasma membrane 5
vacuole 5
lysosome 4
mitochondrion 3
chloroplast 2

Gene Ontology (GO) - Cellular Components for EEF1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,TAS 3512269
GO:0005853 eukaryotic translation elongation factor 1 complex TAS 2564392
GO:0016020 membrane IDA 19946888
GO:0032587 ruffle membrane IDA 19158340
GO:0098574 cytoplasmic side of lysosomal membrane NAS 20797626
genes like me logo Genes that share ontologies with EEF1A1: view

Pathways & Interactions for EEF1A1 Gene

genes like me logo Genes that share pathways with EEF1A1: view

Pathways by source for EEF1A1 Gene

1 Cell Signaling Technology pathway for EEF1A1 Gene
2 BioSystems pathways for EEF1A1 Gene

SIGNOR curated interactions for EEF1A1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for EEF1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with EEF1A1: view

Drugs & Compounds for EEF1A1 Gene

(33) Drugs for EEF1A1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma Target 0
Guanosine triphosphate Experimental Pharma 0

(30) Additional Compounds for EEF1A1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with EEF1A1: view

Transcripts for EEF1A1 Gene

Unigene Clusters for EEF1A1 Gene

Eukaryotic translation elongation factor 1 alpha 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EEF1A1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6
SP1:
SP2:
SP3:

Relevant External Links for EEF1A1 Gene

GeneLoc Exon Structure for
EEF1A1
ECgene alternative splicing isoforms for
EEF1A1

Expression for EEF1A1 Gene

mRNA expression in normal human tissues for EEF1A1 Gene

Protein differential expression in normal tissues from HIPED for EEF1A1 Gene

This gene is overexpressed in Breast (23.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EEF1A1 Gene



SOURCE GeneReport for Unigene cluster for EEF1A1 Gene Hs.535192

mRNA Expression by UniProt/SwissProt for EEF1A1 Gene

P68104-EF1A1_HUMAN
Tissue specificity: Brain, placenta, lung, liver, kidney, pancreas but barely detectable in heart and skeletal muscle.
genes like me logo Genes that share expression patterns with EEF1A1: view

Protein tissue co-expression partners for EEF1A1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for EEF1A1 Gene

Orthologs for EEF1A1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EEF1A1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EEF1A1 35
  • 91.77 (n)
  • 100 (a)
EEF1A1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC102151992 35
  • 92.57 (n)
  • 96.75 (a)
EEF1A1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eef1a1 35
  • 91.85 (n)
  • 99.78 (a)
Eef1a1 16
Eef1a1 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EEF1A1 35
  • 99.86 (n)
  • 100 (a)
EEF1A1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eef1a1 35
  • 91.63 (n)
  • 99.78 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 100 (a)
OneToMany
-- 36
  • 54 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia EEF1A1 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves EEF1A1 35
  • 86.29 (n)
  • 99.13 (a)
EEF1A 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EEF1A1 36
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eef1a1o 35
  • 78.26 (n)
  • 91.52 (a)
MGC75658 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
eef1a1a 35
  • 81.46 (n)
  • 94.81 (a)
eef1a1a 36
  • 95 (a)
OneToMany
eef1a1b 36
  • 94 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1771 35
fruit fly
(Drosophila melanogaster)
Insecta Ef1alpha100E 37
  • 84 (a)
Ef1alpha48D 37
  • 85 (a)
Ef1alpha100E 36
  • 85 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea eft-3 37
  • 83 (a)
eef-1A.1 36
  • 83 (a)
ManyToMany
eef-1A.2 36
  • 83 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TEF2 36
  • 81 (a)
OneToMany
TEF1 38
TEF1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G07940 35
  • 71.99 (n)
  • 77.98 (a)
soybean
(Glycine max)
eudicotyledons Gma.10761 35
rice
(Oryza sativa)
Liliopsida Os03g0177500 35
  • 71.66 (n)
  • 79.19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 78 (a)
ManyToMany
CSA.11100 36
  • 84 (a)
ManyToMany
CSA.11147 36
  • 37 (a)
ManyToMany
CSA.4537 36
  • 82 (a)
ManyToMany
Species with no ortholog for EEF1A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EEF1A1 Gene

ENSEMBL:
Gene Tree for EEF1A1 (if available)
TreeFam:
Gene Tree for EEF1A1 (if available)

Paralogs for EEF1A1 Gene

Paralogs for EEF1A1 Gene

genes like me logo Genes that share paralogs with EEF1A1: view

Variants for EEF1A1 Gene

Sequence variations from dbSNP and Humsavar for EEF1A1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1128073 -- 73,516,522(-) TCCTC(A/C)TGGGT utr-variant-3-prime
rs1390082 -- 73,516,595(+) AAAAA(A/T)TTTTA utr-variant-3-prime
rs1874229 -- 73,518,283(+) TTTGC(A/G)TTCAG intron-variant
rs1874230 -- 73,518,326(+) CTGCA(A/G)TAAGT intron-variant
rs11340128 -- 73,515,854(+) AAGTT(-/A)ATCTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for EEF1A1 Gene

Variant ID Type Subtype PubMed ID
nsv886158 CNV Gain 21882294
nsv5350 CNV Loss 18451855
nsv886159 CNV Loss 21882294
esv2675873 CNV Deletion 23128226
nsv463153 CNV Loss 19166990

Variation tolerance for EEF1A1 Gene

Residual Variation Intolerance Score: 25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.40; 8.75% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for EEF1A1 Gene

Disorders for EEF1A1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for EEF1A1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
tinea nigra
  • infection by cladosporium werneckii
cutaneous anthrax
  • anthrax, skin type
fusariosis
  • fusarium infection
bardet-biedl syndrome
  • laurence-moon syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for EEF1A1

Genetic Association Database (GAD)
EEF1A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EEF1A1
genes like me logo Genes that share disorders with EEF1A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EEF1A1 Gene

Publications for EEF1A1 Gene

  1. Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm. (PMID: 12426392) Bohnsack M.T. … Goerlich D. (EMBO J. 2002) 3 4 23 67
  2. Eukaryotic translation initiator protein 1A isoform, CCS-3, enhances the transcriptional repression of p21CIP1 by proto-oncogene FBI-1 (Pokemon/ZBTB7A). (PMID: 19471103) Choi W.I. … Hur M.W. (Cell. Physiol. Biochem. 2009) 3 23
  3. Cathepsin D and eukaryotic translation elongation factor 1 as promising markers of cellular senescence. (PMID: 19487283) Byun H.O. … Lee J.S. (Cancer Res. 2009) 3 23
  4. Interaction of elongation factor 1-alpha with leucine-rich repeat kinase 2 impairs kinase activity and microtubule bundling in vitro. (PMID: 19559761) Gillardon F. (Neuroscience 2009) 3 23
  5. Structural models of human eEF1A1 and eEF1A2 reveal two distinct surface clusters of sequence variation and potential differences in phosphorylation. (PMID: 19636410) Soares D.C. … Abbott C.M. (PLoS ONE 2009) 3 23

Products for EEF1A1 Gene

Sources for EEF1A1 Gene

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