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Aliases for EED Gene

Aliases for EED Gene

  • Embryonic Ectoderm Development 2 3
  • WD Protein Associating With Integrin Cytoplasmic Tails 1 2 3 4
  • WAIT1 3 6
  • HEED 3 4
  • Polycomb Protein EED 3
  • WAIT-1 4

External Ids for EED Gene

Summaries for EED Gene

Entrez Gene Summary for EED Gene

  • This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein interacts with enhancer of zeste 2, the cytoplasmic tail of integrin beta7, immunodeficiency virus type 1 (HIV-1) MA protein, and histone deacetylase proteins. This protein mediates repression of gene activity through histone deacetylation, and may act as a specific regulator of integrin function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for EED Gene

EED (Embryonic Ectoderm Development) is a Protein Coding gene. Diseases associated with EED include hiv-1. Among its related pathways are Cellular Senescence and Cellular Senescence. GO annotations related to this gene include identical protein binding and histone methyltransferase activity.

UniProtKB/Swiss-Prot for EED Gene

  • Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates Lys-9 and Lys-27 of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes Lys-26 trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 Lys-27, whereas H3 Lys-27 recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.

Gene Wiki entry for EED Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EED Gene

Genomics for EED Gene

Genomic Location for EED Gene

Start:
86,244,544 bp from pter
End:
86,285,420 bp from pter
Size:
40,877 bases
Orientation:
Plus strand

Genomic View for EED Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EED Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EED Gene

Regulatory Elements for EED Gene

Proteins for EED Gene

  • Protein details for EED Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75530-EED_HUMAN
    Recommended name:
    Polycomb protein EED
    Protein Accession:
    O75530
    Secondary Accessions:
    • A8K7V5
    • O00149
    • Q6NTH2
    • Q7LDA5
    • Q7LDG8
    • Q86VV2
    • Q9UNY7

    Protein attributes for EED Gene

    Size:
    441 amino acids
    Molecular mass:
    50198 Da
    Quaternary structure:
    • Interacts with KMT2A/MLL1 (By similarity). Component of the PRC2/EED-EZH2 complex, which includes EED, EZH2, SUZ12, RBBP4 and RBBP7 and possibly AEBP2. The minimum components required for methyltransferase activity of the PRC2/EED-EZH2 complex are EED, EZH2 and SUZ12. Component of the PRC2/EED-EZH1 complex, which includes EED, EZH1, SUZ12, RBBP4 and AEBP2. The PRC2 complex may also interact with DNMT1, DNMT3A, DNMT3B and PHF1 via the EZH2 subunit and with SIRT1 via the SUZ12 subunit. Interacts with HDAC, HDAC2, histone H1 and YY1. May interact with ITGA4, ITGAE and ITGB7. Interacts with CDYL. May interact with the MA protein of HIV-1. Interacts with ARNTL/BMAL1.
    SequenceCaution:
    • Sequence=AAC23685.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAC68675.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for EED Gene

    Alternative splice isoforms for EED Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EED Gene

Proteomics data for EED Gene at MOPED

Post-translational modifications for EED Gene

  • Methylated. Binding to histone H1 Lys-26 promotes mono-, di-, and trimethylation of internal lysines.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys275

Other Protein References for EED Gene

No data available for DME Specific Peptides for EED Gene

Domains for EED Gene

Gene Families for EED Gene

HGNC:
  • WDR :WD repeat domain containing

Protein Domains for EED Gene

Suggested Antigen Peptide Sequences for EED Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75530

UniProtKB/Swiss-Prot:

EED_HUMAN
Domain:
  • The WD repeat domain mediates recognition of trimethylated histone peptides at the consensus sequence Ala-Arg-Lys-Ser. This is achieved through an aromatic cage encircling the methyllysine, and involving Phe-97, Tyr-148 and Tyr-365.:
    • O75530
Family:
  • Belongs to the WD repeat ESC family.:
    • O75530
Similarity:
  • Contains 7 WD repeats.:
    • O75530
genes like me logo Genes that share domains with EED: view

Function for EED Gene

Molecular function for EED Gene

GENATLAS Biochemistry: murine embryonic ectoderm development (eed) homolog,polycomb-group PcG, homology with Drosophila extra sex comb,ubiquitously expressed,interacting with EZH2,HDAC proteins and involved in transcriptional repression through this interaction
UniProtKB/Swiss-Prot Function: Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates Lys-9 and Lys-27 of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes Lys-26 trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 Lys-27, whereas H3 Lys-27 recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.
UniProtKB/Swiss-Prot Induction: Expression is induced by E2F1, E2F2 and E2F3.

Gene Ontology (GO) - Molecular Function for EED Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
GO:0005515 protein binding IPI 16357870
GO:0042054 histone methyltransferase activity IDA 15385962
GO:0042802 identical protein binding IPI 11124122
genes like me logo Genes that share ontologies with EED: view
genes like me logo Genes that share phenotypes with EED: view

miRNA for EED Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for EED Gene

Localization for EED Gene

Subcellular locations from UniProtKB/Swiss-Prot for EED Gene

Nucleus. Chromosome. Note=Transiently colocalizes with XIST at inactive X chromosomes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EED Gene COMPARTMENTS Subcellular localization image for EED gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for EED Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001739 sex chromatin IEA --
GO:0005634 nucleus NAS 9584199
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with EED: view

Pathways for EED Gene

genes like me logo Genes that share pathways with EED: view

Pathways by source for EED Gene

Gene Ontology (GO) - Biological Process for EED Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization TAS --
GO:0006349 regulation of gene expression by genetic imprinting IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0010467 gene expression TAS --
GO:0016571 histone methylation IEA --
genes like me logo Genes that share ontologies with EED: view

Transcripts for EED Gene

Unigene Clusters for EED Gene

Embryonic ectoderm development:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EED Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13
SP1: -
SP2: - -
SP3: -
SP4: - - - -
SP5: -
SP6: - - - - - - - - - -

Relevant External Links for EED Gene

GeneLoc Exon Structure for
EED
ECgene alternative splicing isoforms for
EED

Expression for EED Gene

mRNA expression in normal human tissues for EED Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EED Gene

SOURCE GeneReport for Unigene cluster for EED Gene Hs.503510

mRNA Expression by UniProt/SwissProt for EED Gene

O75530-EED_HUMAN
Tissue specificity: Expressed in brain, colon, heart, kidney, liver, lung, muscle, ovary, peripheral blood leukocytes, pancreas, placenta, prostate, spleen, small intestine, testis, thymus and uterus. Appears to be overexpressed in breast and colon cancer.
genes like me logo Genes that share expressions with EED: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for EED Gene

Orthologs for EED Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EED Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EED 35
  • 95.99 (n)
  • 99.77 (a)
EED 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EED 35
  • 95.77 (n)
  • 100 (a)
EED 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eed 35
  • 92.59 (n)
  • 100 (a)
Eed 16
Eed 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EED 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EED 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eed 35
  • 93.05 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves EED 35
  • 85.68 (n)
  • 97.05 (a)
EED 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EED 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eed 35
  • 79.82 (n)
  • 94.27 (a)
Str.6112 35
zebrafish
(Danio rerio)
Actinopterygii Dr.14507 35
eed 35
  • 74.55 (n)
  • 92.2 (a)
eed 36
  • 89 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta esc 36
  • 50 (a)
OneToMany
escl 35
  • 57.4 (n)
  • 57.57 (a)
escl 36
  • 50 (a)
OneToMany
esc 37
  • 55 (a)
CG5202 37
  • 58 (a)
worm
(Caenorhabditis elegans)
Secernentea mes-6 36
  • 22 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons FIE 35
  • 52.52 (n)
  • 43.31 (a)
rice
(Oryza sativa)
Liliopsida Os08g0137100 35
  • 53.43 (n)
  • 46.18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6528 36
  • 60 (a)
OneToOne
Species with no ortholog for EED:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EED Gene

ENSEMBL:
Gene Tree for EED (if available)
TreeFam:
Gene Tree for EED (if available)

Paralogs for EED Gene

Pseudogenes.org Pseudogenes for EED Gene

genes like me logo Genes that share paralogs with EED: view

No data available for Paralogs for EED Gene

Variants for EED Gene

Sequence variations from dbSNP and Humsavar for EED Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs291250 -- 86,283,124(-) CTAGT(A/G)TCCAC intron-variant
rs291251 -- 86,282,854(-) CTATG(C/T)TCCAC intron-variant
rs291252 -- 86,282,276(-) TGTAC(A/G)AAAAT intron-variant
rs974144 -- 86,257,581(-) TGACA(A/G)GAGAA reference, synonymous-codon, nc-transcript-variant
rs991435 -- 86,248,322(+) TAAGT(C/G)ATCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EED Gene

Variant ID Type Subtype PubMed ID
nsv832223 CNV Loss 17160897
nsv898055 CNV Loss 21882294
nsv513328 CNV Insertion 21212237
esv2542002 CNV Insertion 19546169
esv1712509 CNV Insertion 17803354
nsv508643 CNV Loss 20534489

Relevant External Links for EED Gene

HapMap Linkage Disequilibrium report
EED
Human Gene Mutation Database (HGMD)
EED

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EED Gene

Disorders for EED Gene

(1) MalaCards Diseases for EED Gene

Search for EED Gene in MalaCards »

(2) Novoseek inferred disease relationships for EED Gene

Disease -log(P) Hits PubMed IDs
prostate cancer 4.66 1
tumors 0 1
genes like me logo Genes that share disorders with EED: view

No data available for UniProtKB/Swiss-Prot for EED Gene

Publications for EED Gene

  1. The human WD repeat protein WAIT-1 specifically interacts with the cytoplasmic tails of beta7-integrins. (PMID: 9765275) Rietzler M. … Holzmann B. (J. Biol. Chem. 1998) 2 3 4 23
  2. The murine Polycomb-group gene eed and its human orthologue: functional implications of evolutionary conservation. (PMID: 9806832) Schumacher A. … Magnuson T. (Genomics 1998) 2 3 4 23
  3. Substrate preferences of the EZH2 histone methyltransferase complex. (PMID: 16431907) Martin C. … Zhang Y. (J. Biol. Chem. 2006) 3 4 23
  4. Characterization of interactions between the mammalian polycomb-group proteins Enx1/EZH2 and EED suggests the existence of different mammalian polycomb-group protein complexes. (PMID: 9584199) Sewalt R.G.A.B. … Otte A.P. (Mol. Cell. Biol. 1998) 3 4 23
  5. HEED, the product of the human homolog of the murine eed gene, binds to the matrix protein of HIV-1. (PMID: 9880543) Peytavi R. … Boulanger P. (J. Biol. Chem. 1999) 3 4

Products for EED Gene

  • Addgene plasmids for EED

Sources for EED Gene

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