EED Gene
protein-coding GIFtS: 56
GCID: GC11P085955
|
|
embryonic ectoderm development
| |
Aliases
for EED gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Embryonic Ectoderm Development1 2 | | WAIT12 5 | | HEED1 2 | | Polycomb Protein EED2 | | WAIT-11 3 | | HEED1 2 | | WD Protein Associating With Integrin Cytoplasmic Tails 12 3 | | |
Export aliases for EED gene to outside databasesPrevious GC identifers: GC11P088282 GC11P087494 GC11P086178 GC11P085682 GC11P085633 GC11P082243 |
Summaries
for EED gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for EED:
This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes,which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. Thisprotein interacts with enhancer of zeste 2, the cytoplasmic tail of integrin beta7, immunodeficiency virus type 1(HIV-1) MA protein, and histone deacetylase proteins. This protein mediates repression of gene activity throughhistone deacetylation, and may act as a specific regulator of integrin function. Two transcript variants encodingdistinct isoforms have been identified for this gene. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: EED_HUMAN, O75530Function: Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27'of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26'trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histoneH3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressivemark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linkingtwo epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A
Gene Wiki entry for EED
|
Genomic Views
for EED gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the EED gene promoter:
p53 GATA-3 Pax-2 Pax-2a GATA-2 Pax-2b FOXJ2 (long isoform) Chx10 Msx-1 FOXJ2
Other transcription factors
Search SABiosciences Chromatin IP Primers for EED
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EED |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q14.2-q22.3 Ensembl cytogenetic band: 11q14.2 HGNC cytogenetic band: 11q14.2-q22.3EED Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P085955: view genomic region
(about GC identifiers)
Start:
|
85,955,586 bp from pter |
End:
|
85,989,781 bp from pter |
Size:
|
34,196 bases |
Orientation:
|
plus strand |
|
Proteins
for EED gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: EED_HUMAN, O75530 (See
protein sequence)Recommended Name: Polycomb protein EED Size: 441 amino acids; 50198 Da
Subunit: Interacts with MLL (By similarity). Component of the PRC2/EED-EZH2 complex, which includes EED, EZH2, SUZ12,RBBP4 and RBBP7 and possibly AEBP2. The minimum components required for methyltransferase activity of thePRC2/EED-EZH2 complex are EED, EZH2 and SUZ12. Component of the PRC2/EED-EZH1 complex, which includes EED, EZH1,SUZ12, RBBP4 and AEBP2. The PRC2 complex may also interact with DNMT1, DNMT3A, DNMT3B and PHF1 via the EZH2 subunitand with SIRT1 via the SUZ12 subunit. Interacts with HDAC, HDAC2, histone H1 and YY1. May interact with ITGA4, ITGAEand ITGB7. May interact with the MA protein of HIV-1
Subcellular location: Nucleus. Chromosome. Note=Transiently colocalizes with XIST at inactive X chromosomes
Developmental stage: Expression peaks at the G1/S phase boundary
Caution: Two variants of the PRC2 complex have been described, termed PRC3 and PRC4. Each of the three complexes mayinclude a different complement of EED isoforms, although the precise sequences of the isoforms in each complex havenot been determined. The PRC2 and PRC4 complexes may also methylate 'Lys-26' of histone H1 in addition to 'Lys-27' ofhistone H3 (PubMed:15099518 and PubMed:15684044), although other studies have demonstrated no methylation of 'Lys-26'of histone H1 by PRC2 (PubMed:16431907)
Sequence caution: Sequence=AAC23685.1; Type=Erroneous initiation; Sequence=AAC68675.1; Type=Erroneous initiation;
6/11 PDB 3D structures from  and Proteopedia  for EED (see all 11):3IIW (3D)
3IIY (3D)
3IJ0 (3D)
3IJ1 (3D)
3IJC (3D)
3JPX (3D)
Secondary accessions: A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7Alternative splicing, Alternative initiation: 3 isoforms: O75530-1 O75530-2 O75530-3 Explore the universe of human proteins at neXtProt for EED: NX_O75530
Post-translational modifications:
Methylated. Binding to histone H1 'Lys-26' promotes mono-, di-, and trimethylation of internal lysines1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O75530
EED Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_003788.2 NP_694536.1
ENSEMBL proteins: ENSP00000263360 ENSP00000431778 ENSP00000315587 ENSP00000338186 ENSP00000436084 ENSP00000437318
Human Recombinant Protein Products for EED:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
EED for ontologies About GeneDecksing
EED Antibody Products:
Assay Products for EED: |
Protein
Domains /
Families
for EED gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
EED for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O75530ProtoNet protein and cluster: O75530 UniProtKB/Swiss-Prot: EED_HUMAN, O75530Domain: The WD repeat domain mediates recognition of trimethylated histone peptides at the consensus sequenceAla-Arg-Lys-Ser. This is achieved through an aromatic cage encircling the methyllysine, and involving Phe-97, Tyr-148and Tyr-365Similarity: Belongs to the WD repeat ESC familySimilarity: Contains 7 WD repeats |
Function
for EED gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: EED_HUMAN, O75530Function: Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27'of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26'trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histoneH3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressivemark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linkingtwo epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2AInduction: Expression is induced by E2F1, E2F2 and E2F3 Genatlas biochemistry entry for EED:murine embryonic ectoderm development (eed) homolog,polycomb-group PcG, homology with Drosophila extra sexcomb,ubiquitously expressed,interacting with EZH2,HDAC proteins and involved in transcriptional repression throughthis interaction
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
EED for ontologies About GeneDecksing
Phenotypes:
4 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Eed):
EED for phenotypes About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EED (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EED (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): EED (NM_003797) | |  | Sino Biological Human cDNA Clone for EED | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EED | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EED |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EED |
|
Pathways & Interactions
for EED gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for EED
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/138 Interacting proteins for EED (O755301, 2, 3 ENSP000002633604) via UniProtKB, MINT, STRING, and/or I2D (see all 138)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006349 | regulation of gene expression by genetic imprinting |
IEA | -- | | GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0016571 | histone methylation |
-- | -- | | GO:0045892 | negative regulation of transcription, DNA-dependent |
NAS | 9584199 |
EED for ontologies About GeneDecksing
|
Drugs & Compounds
for EED gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for EED
Search CenterWatch for drugs/clinical trials and news about EED
|
Transcripts
for EED gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for EED gene (2 alternative transcripts): NM_003797.3 NM_152991.2 Unigene Cluster for EED: Embryonic ectoderm development Hs.503510 [show with all ESTs]Unigene Representative Sequence: NM_15299111 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000263360(uc010rtm.2 uc001pbp.3 uc001pbr.3) ENST00000528180
ENST00000327320(uc001pbq.3) ENST00000351625 ENST00000534595 ENST00000525244(uc010rtn.1)
ENST00000533228 ENST00000534564 ENST00000524673 ENST00000527888 ENST00000528250
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EED (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EED (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): EED (NM_003797) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EED | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EED |
Additional cDNA sequence: AF070418.1 AF078933.1 AF080227.1 AF099032.1 AK292120.1 AK294133.1 AK301265.1 BC047672.2 BC068995.1 U90651.1 7 DOTS entries: DT.213873 DT.100751944 DT.99988495 DT.95166920 DT.120680451 DT.75121196 DT.97839611 24/123 AceView cDNA sequences (see all 123): BU172591 AI921064 AA635557 BM998102 AI474282 BM665282 AI990456 BC047672 BI834870 NM_152991 CR616258 CA944902 BG122265 NM_003797 BE644956 BQ013569 AI690903 BU608156 BI856105 AI419291 AU100108 AI630913 AA384638 BM680764
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for EED (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | - | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for EED
|
Expression
for EED gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| EED expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See EED Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for EED
SOURCE GeneReport for Unigene cluster: Hs.503510
UniProtKB/Swiss-Prot: EED_HUMAN, O75530Tissue specificity: Expressed in brain, colon, heart, kidney, liver, lung, muscle, ovary, peripheral blood leukocytes,pancreas, placenta, prostate, spleen, small intestine, testis, thymus and uterus. Appears to be overexpressed inbreast and colon cancer
SABiosciences Expression via Pathway-Focused PCR Arrays including EED: | Epigenetic Chromatin Modification Enzymes in human mouse rat | | Polycomb & Trithorax Complexes in human mouse rat | | Epigenetic Chromatin Remodeling Factors in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EED
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EED | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EED | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EED | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EED |
Orthologs
for EED gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for EED gene from 9/26 species (see all 26) About this table
ENSEMBL Gene Tree for EED (if available)
TreeFam Gene Tree for EED (if available) |
Paralogs
for EED gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for EED gene
EED for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for EED
PGOHUM00000245982 PGOHUM00000242049
|
Genomic Variants
for EED gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for EED (85955586 - 85989781 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for EED
1 Indel: 101281
Human Gene Mutation Database (HGMD): EED
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EED |
|
Disorders
/ Diseases
for EED gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
EED for disorders About GeneDecksing
OMIM gene information: 605984
OMIM disorders: --
10  diseases for EED: About MalaCardsimmunodeficiency x inactivation acute promyelocytic leukemia fainting
hodgkin's lymphoma prostate cancer colon cancer prostatitis
leukemia hepatitis
2 Novoseek disease relationships for EED gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| prostate cancer |
4.66 |
1 |
17134822 (1) |
| tumors |
0 |
1 |
20444294 (1) |
Export disorders for EED gene to outside databases
|
Publications
for EED gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for EED gene, integrated from 9 sources (see all 85):
(articles sorted by number of sources associating them with EED) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The human WD repeat protein WAIT-1 specifically interacts with the cytoplasmic tails of beta7-integrins. (PubMed id 9765275)1, 2, 3, 9 Rietzler M.... Holzmann B. (1998)
- The murine Polycomb-group gene eed and its human orthologue: functional implications of evolutionary conservation. (PubMed id 9806832)1, 2, 3, 9 Schumacher A.... Magnuson T. (1998)
- Substrate preferences of the EZH2 histone methyltransferase complex. (PubMed id 16431907)1, 2, 9 Martin C.... Zhang Y. (2006)
- Characterization of interactions between the mammalian polycomb-group proteins Enx1/EZH2 and EED suggests the existence of different mammalian polycomb-group protein complexes. (PubMed id 9584199)1, 2, 9 Sewalt R.G.A.B.... Otte A.P. (1998)
- Binding of different histone marks differentially reg ulates the activity and specificity of polycomb repressive complex 2 (PRC2). (PubMed id 20974918)1, 2 Xu C....Min J. (2010)
- Ezh2 requires PHF1 to efficiently catalyze H3 lysine 27 trimethylation in vivo. (PubMed id 18285464)1, 2 Sarma K....Reinberg D. (2008)
- Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms. (PubMed id 19026781)1, 2 Margueron R.... Reinberg D. (2008)
- The Polycomb group protein EZH2 directly controls DNA methylation. (PubMed id 16357870)1, 2 Vire E.... Fuks F. (2006)
- SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex. (PubMed id 15225548)1, 2 Cao R. and Zhang Y. (2004)
- Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity. (PubMed id 15385962)1, 2 Pasini D.... Helin K. (2004)
|
External Searches for EED gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing EED gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing EED gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing EED gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for EED | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for EED gene:
Search GeneIP for patents involving EED
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for EED gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
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| | |  | OriGene Antibodies for EED | | OriGene shRNA RFP for EED | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EED | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EED | | | OriGene Protein Over-expression Lysate for EED | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for EED | | OriGene 3'-UTR Clone for EED | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EED | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EED | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for EED | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for EED | | OriGene Custom Protein Services for EED | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat EED | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EED | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EED | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EED | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EED | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EED |
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| | | | Search Tocris compounds for EED |
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 | | | EED Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EED |
|  |  |  |  | | | | ThermoFisher Antibody for EED |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EED |
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