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EED Gene

protein-coding   GIFtS: 60
GCID: GC11P085955

Embryonic Ectoderm Development

  See EED-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Embryonic Ectoderm Development1 2     Polycomb Protein EED2
WD Protein Associating With Integrin Cytoplasmic Tails 11 2 3     WAIT-13
WAIT12 5     hEED3
HEED2     

External Ids:    HGNC: 31881   Entrez Gene: 87262   Ensembl: ENSG000000742667   OMIM: 6059845   UniProtKB: O755303   

Export aliases for EED gene to outside databases

Previous GC identifers: GC11P088282 GC11P087494 GC11P086178 GC11P085682 GC11P085633 GC11P082243


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for EED Gene:
This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein
complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell
generations. This protein interacts with enhancer of zeste 2, the cytoplasmic tail of integrin beta7,
immunodeficiency virus type 1 (HIV-1) MA protein, and histone deacetylase proteins. This protein mediates
repression of gene activity through histone deacetylation, and may act as a specific regulator of integrin
function. Two transcript variants encoding distinct isoforms have been identified for this gene. (provided by
RefSeq, Jul 2008)

GeneCards Summary for EED Gene:
EED (embryonic ectoderm development) is a protein-coding gene. Diseases associated with EED include hiv-1. GO annotations related to this gene include histone methyltransferase activity and identical protein binding.

UniProtKB/Swiss-Prot: EED_HUMAN, O75530
Function: Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and
'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes
'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on
nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the
propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA
methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2
complex include HOXC8, HOXA9, MYT1 and CDKN2A

Gene Wiki entry for EED Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the EED gene promoter:
         p53   GATA-3   Pax-2   Pax-2a   GATA-2   Pax-2b   FOXJ2 (long isoform)   Chx10   Msx-1   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEED promoter sequence
   Search Chromatin IP Primers for EED

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EED


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q14.2-q22.3   Ensembl cytogenetic band:  11q14.2   HGNC cytogenetic band: 11q14.2-q22.3

EED Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EED gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P085955:  view genomic region     (about GC identifiers)

Start:
85,955,586 bp from pter      End:
85,989,855 bp from pter
Size:
34,270 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: EED_HUMAN, O75530 (See protein sequence)
Recommended Name: Polycomb protein EED  
Size: 441 amino acids; 50198 Da
Subunit: Interacts with KMT2A/MLL1 (By similarity). Component of the PRC2/EED-EZH2 complex, which includes EED,
EZH2, SUZ12, RBBP4 and RBBP7 and possibly AEBP2. The minimum components required for methyltransferase activity
of the PRC2/EED-EZH2 complex are EED, EZH2 and SUZ12. Component of the PRC2/EED-EZH1 complex, which includes EED,
EZH1, SUZ12, RBBP4 and AEBP2. The PRC2 complex may also interact with DNMT1, DNMT3A, DNMT3B and PHF1 via the EZH2
subunit and with SIRT1 via the SUZ12 subunit. Interacts with HDAC, HDAC2, histone H1 and YY1. May interact with
ITGA4, ITGAE and ITGB7. Interacts with CDYL. May interact with the MA protein of HIV-1
Developmental stage: Expression peaks at the G1/S phase boundary
Caution: Two variants of the PRC2 complex have been described, termed PRC3 and PRC4. Each of the three complexes
may include a different complement of EED isoforms, although the precise sequences of the isoforms in each
complex have not been determined. The PRC2 and PRC4 complexes may also methylate 'Lys-26' of histone H1 in
addition to 'Lys-27' of histone H3 (PubMed:15099518 and PubMed:15684044), although other studies have
demonstrated no methylation of 'Lys-26' of histone H1 by PRC2 (PubMed:16431907)
Sequence caution: Sequence=AAC23685.1; Type=Erroneous initiation; Sequence=AAC68675.1; Type=Erroneous initiation;
Selected PDB 3D structures from and Proteopedia for EED (see all 11):
3IIW (3D)        3IIY (3D)        3IJ0 (3D)        3IJ1 (3D)        3IJC (3D)        3JPX (3D)    
Secondary accessions: A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7
Alternative splicing, Alternative initiation: 3 isoforms:  O75530-1   O75530-2   O75530-3   

Explore the universe of human proteins at neXtProt for EED: NX_O75530

Explore proteomics data for EED at MOPED

Post-translational modifications: 

  • Methylated. Binding to histone H1 'Lys-26' promotes mono-, di-, and trimethylation of internal lysines1
  • Ubiquitination2 at Lys275
  • Modification sites at PhosphoSitePlus

  • See EED Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_003788.2  NP_694536.1  

    ENSEMBL proteins: 
     ENSP00000263360   ENSP00000431778   ENSP00000315587   ENSP00000338186   ENSP00000436084  
     ENSP00000437318  
    Reactome Protein details: O75530

    EED Human Recombinant Protein Products:

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    Novus Biologicals EED Proteins
    Novus Biologicals EED Lysates
    Sino Biological Recombinant Protein for EED
    Sino Biological Cell Lysate for EED
    ProSpec Recombinant Protein for EED
    Cloud-Clone Corp. Proteins for EED

     
    Search eBioscience for Proteins for EED 

     
    antibodies-online proteins for EED (9 products) 

     
    antibodies-online peptides for EED

    EED Antibody Products:

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    antibodies-online antibodies for EED (41 products) 

    EED Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for EED
    Cloud-Clone Corp. CLIAs for EED
    Search eBioscience for ELISAs for EED 
    antibodies-online kits for EED (27 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing

    4 InterPro protein domains:
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry O75530

    ProtoNet protein and cluster: O75530

    UniProtKB/Swiss-Prot: EED_HUMAN, O75530
    Domain: The WD repeat domain mediates recognition of trimethylated histone peptides at the consensus sequence
    Ala-Arg-Lys-Ser. This is achieved through an aromatic cage encircling the methyllysine, and involving Phe-97,
    Tyr-148 and Tyr-365
    Similarity: Belongs to the WD repeat ESC family
    Similarity: Contains 7 WD repeats


    Find genes that share domains with EED           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EED_HUMAN, O75530
    Function: Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and
    'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes
    'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on
    nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the
    propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA
    methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2
    complex include HOXC8, HOXA9, MYT1 and CDKN2A
    Induction: Expression is induced by E2F1, E2F2 and E2F3

         Genatlas biochemistry entry for EED:
    murine embryonic ectoderm development (eed) homolog,polycomb-group PcG, homology with Drosophila extra sex
    comb,ubiquitously expressed,interacting with EZH2,HDAC proteins and involved in transcriptional repression
    through this interaction

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IEA--
    GO:0005515protein binding IPI16357870
    GO:0042054histone methyltransferase activity IDA15385962
    GO:0042802identical protein binding IPI11124122
         
    Find genes that share ontologies with EED           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Eed):
     growth/size/body  hematopoietic system  integument  pigmentation 

    Find genes that share phenotypes with EED           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for EED

    miRNA
    Products:
        
    miRTarBase miRNAs that target EED:
    hsa-mir-30c-5p (MIRT048018), hsa-mir-101-3p (MIRT004086), hsa-mir-26b-5p (MIRT029750), hsa-mir-138-5p (MIRT021689)

    Block miRNA regulation of human, mouse, rat EED using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EED (see all 14):
    hsa-miR-30c hsa-miR-34c-3p hsa-miR-181c hsa-miR-513a-3p hsa-miR-499-3p hsa-miR-30d hsa-miR-181a hsa-miR-181d
    SwitchGear 3'UTR luciferase reporter plasmidEED 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for EED
    Predesigned siRNA for gene silencing in human, mouse, rat EED

    Gene Editing
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    OriGene clones in human, mouse for EED (see all 11)
    OriGene ORF clones in mouse, rat for EED
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    GenScript: all cDNA clones in your preferred vector (see all 2): EED (NM_003797)
    Sino Biological Human cDNA Clone for EED
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EED
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EED
    Addgene plasmids for EED 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EED


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EED_HUMAN, O75530: Nucleus. Chromosome. Note=Transiently colocalizes with XIST at inactive X chromosomes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001739sex chromatin IEA--
    GO:0005634nucleus NAS9584199
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with EED           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for EED About    
    See pathways by source

    SuperPathContained pathways About
    1Cellular Senescence
    Cellular Senescence0.81
    Oxidative Stress Induced Senescence0.64
    Cellular responses to stress0.81


    Find genes that share SuperPaths with EED           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Reactome Pathways for EED
        Oxidative Stress Induced Senescence
    PRC2 methylates histones and DNA


        Pathway & Disease-focused RT2 Profiler PCR Arrays including EED: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Polycomb & Trithorax Complexes in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for EED

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for EED (O755301, 2, 3 ENSP000002633604) via UniProtKB, MINT, STRING, and/or I2D (see all 199)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3AP684313, ENSP000003502754I2D: score=1 STRING: ENSP00000350275
    HIST1H3BP684313I2D: score=1 
    HIST1H3CP684313I2D: score=1 
    HIST1H3DP684313I2D: score=1 
    HIST1H3EP684313I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006349regulation of gene expression by genetic imprinting IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0016571histone methylation ----
    GO:0045892negative regulation of transcription, DNA-templated NAS9584199
    GO:0061087positive regulation of histone H3-K27 methylation IEA--

    Find genes that share ontologies with EED           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EED



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for EED gene (2 alternative transcripts): 
    NM_003797.3  NM_152991.2  

    Unigene Cluster for EED:

    Embryonic ectoderm development
    Hs.503510  [show with all ESTs]
    Unigene Representative Sequence: NM_152991
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263360(uc010rtm.2 uc001pbp.3 uc001pbr.3) ENST00000528180
    ENST00000327320(uc001pbq.3) ENST00000351625 ENST00000534595 ENST00000525244(uc010rtn.1)
    ENST00000533228 ENST00000534564 ENST00000524673 ENST00000527888 ENST00000528250

    miRNA
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    Block miRNA regulation of human, mouse, rat EED using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EED (see all 14):
    hsa-miR-30c hsa-miR-34c-3p hsa-miR-181c hsa-miR-513a-3p hsa-miR-499-3p hsa-miR-30d hsa-miR-181a hsa-miR-181d
    SwitchGear 3'UTR luciferase reporter plasmidEED 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat EED
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): EED (NM_003797)
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    Addgene plasmids for EED 
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    OriGene qSTAR qPCR primer pairs in human, mouse for EED
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EED
      QuantiTect SYBR Green Assays in human, mouse, rat EED
      QuantiFast Probe-based Assays in human, mouse, rat EED

    Additional mRNA sequence: 

    AF070418.1 AF078933.1 AF080227.1 AF099032.1 AK292120.1 AK294133.1 AK301265.1 BC047672.2 
    BC068995.1 U90651.1 

    7 DOTS entries:

    DT.213873  DT.100751944  DT.99988495  DT.95166920  DT.120680451  DT.75121196  DT.97839611 

    Selected AceView cDNA sequences (see all 123):

    AI990456 AA384638 NM_152991 BC047672 BM998102 NM_003797 BM718903 CR616231 
    AI630913 T26911 CR616258 BI834870 AI474282 BE644956 BG678915 AI270650 
    AF080227 BM680764 AI419291 BQ013569 BU608156 N50094 BU172591 BM665282 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for EED (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13
    SP1:                                                                                                                    -         
    SP2:                                                                                            -                       -         
    SP3:                                                                                            -                                 
    SP4:                                                                          -     -     -     -                                 
    SP5:                                            -                                                                                 


    ECgene alternative splicing isoforms for EED

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EED expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    EED Expression
    About this image

    EED Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EED Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.503510

    UniProtKB/Swiss-Prot: EED_HUMAN, O75530
    Tissue specificity: Expressed in brain, colon, heart, kidney, liver, lung, muscle, ovary, peripheral blood
    leukocytes, pancreas, placenta, prostate, spleen, small intestine, testis, thymus and uterus. Appears to be
    overexpressed in breast and colon cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including EED: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Polycomb & Trithorax Complexes in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for EED
    OriGene qSTAR qPCR primer pairs in human, mouse for EED
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EED
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    QuantiFast Probe-based Assays in human, mouse, rat EED
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EED

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for EED gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Eed1 , 5 embryonic ectoderm development1, 5 92.59(n)1
    100(a)1
      7 (50.42 cM)5
    136261  NM_021876.31  NP_068676.11 
     899546565 
    chicken
    (Gallus gallus)
    Aves EED1 embryonic ectoderm development 85.68(n)
    97.05(a)
      426381  NM_001031376.1  NP_001026547.1 
    lizard
    (Anolis carolinensis)
    Reptilia EED6
    embryonic ectoderm development
    92(a)
    1 ↔ 1
    3(200402601-200419283)
    African clawed frog
    (Xenopus laevis)
    Amphibia AJ421945.12   -- 80.66(n)    AJ421945.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.145072 Transcribed sequence with moderate similarity to protein more 76.97(n)    CK028285.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG52023
    escl1
    escl1 58(a)
    (best of 2)3
    57.4(n)1
    57.57(a)1
      33B53
    346111  NM_164979.21  NP_723702.11 
    worm
    (Caenorhabditis elegans)
    Secernentea mes-66
    Protein MES-6 (mes-6) mRNA, complete cds
    22(a)
    1 ↔ 1
    IV(8511284-8513476) WBGene00003224
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons FIE1 FIE 52.52(n)
    43.31(a)
      821622  NM_112965.1  NP_188710.1 
    rice
    (Oryza sativa)
    Liliopsida Os08g01371001 Os08g0137100 53.43(n)
    46.18(a)
      4344620  NM_001067488.1  NP_001060953.1 


    ENSEMBL Gene Tree for EED (if available)
    TreeFam Gene Tree for EED (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for EED gene

    Find genes that share paralogs with EED           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for EED
    PGOHUM00000245982 PGOHUM00000242049


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for EED (see all 834)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1908071601,2
    --85822071(+) CCCCAC/TTCCTT 2 -- us2k10--------
    rs1830061471,2
    --85822083(+) CTGTAA/CTTTGG 2 -- us2k10--------
    rs788132741,2
    C--85822114(+) CTATTG/ATGATA 2 -- us2k13Minor allele frequency- A:0.15NA WA EA 240
    rs1872604211,2
    --85822135(+) CTATCA/CAAATA 2 -- us2k10--------
    rs1927515121,2
    --85822158(+) GTGTTC/TCTTAC 2 -- us2k10--------
    rs1416472171,2
    --85822217(+) CGTAGC/TAATAT 2 -- us2k10--------
    rs1153403211,2
    F--85822313(+) TTTTTG/ACTTTG 2 -- us2k11Minor allele frequency- A:0.06WA 118
    rs771907901,2
    C,F--85822529(+) CTTTGT/CTGGGA 2 -- us2k11Minor allele frequency- C:0.16WA 118
    rs79524811,2
    C,F,A--85822608(+) ACTTTC/GTCAGG 2 -- us2k111Minor allele frequency- G:0.37NA WA CSA EA 373
    rs1461116101,2
    C--85822686(+) GGAAGC/TACTGA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for EED (85955586 - 85989855 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for EED:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv513328CNV Insertion21212237
    esv1712509CNV Insertion17803354
    esv2542002CNV Insertion19546169
    nsv508643CNV Loss20534489
    nsv898055CNV Loss21882294
    nsv832223CNV Loss17160897

    Human Gene Mutation Database (HGMD): EED
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing EED
    DNA2.0 Custom Variant and Variant Library Synthesis for EED

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605984    OMIM disorders: --

    1 disease for EED:    
    About MalaCards
    hiv-1


    Find genes that share disorders with EED           About GenesLikeMe

    2 Novoseek inferred disease relationships for EED gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer 4.66 1 17134822 (1)
    tumors 0 1 20444294 (1)


    Export disorders for EED gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EED gene, integrated from 10 sources (see all 94):
    (articles sorted by number of sources associating them with EED)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human WD repeat protein WAIT-1 specifically interacts with the cytoplasmic tails of beta7-integrins. (PubMed id 9765275)1, 2, 3, 9 Rietzler M.... Holzmann B. (J. Biol. Chem. 1998)
    2. The murine Polycomb-group gene eed and its human orthologue: functional implications of evolutionary conservation. (PubMed id 9806832)1, 2, 3, 9 Schumacher A.... Magnuson T. (Genomics 1998)
    3. Substrate preferences of the EZH2 histone methyltransferase complex. (PubMed id 16431907)1, 2, 9 Martin C.... Zhang Y. (J. Biol. Chem. 2006)
    4. Characterization of interactions between the mammalian polycomb-group proteins Enx1/EZH2 and EED suggests the existence of different mammalian polycomb-group protein complexes. (PubMed id 9584199)1, 2, 9 Sewalt R.G.A.B.... Otte A.P. (Mol. Cell. Biol. 1998)
    5. Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2). (PubMed id 20974918)1, 2 Xu C.... Min J. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    6. Ezh2 requires PHF1 to efficiently catalyze H3 lysine 27 trimethylation in vivo. (PubMed id 18285464)1, 2 Sarma K.... Reinberg D. (Mol. Cell. Biol. 2008)
    7. Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms. (PubMed id 19026781)1, 2 Margueron R.... Reinberg D. (Mol. Cell 2008)
    8. The Polycomb group protein EZH2 directly controls DNA methylation. (PubMed id 16357870)1, 2 Vire E.... Fuks F. (Nature 2006)
    9. SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex. (PubMed id 15225548)1, 2 Cao R. and Zhang Y. (Mol. Cell 2004)
    10. Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity. (PubMed id 15385962)1, 2 Pasini D.... Helin K. (EMBO J. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8726 HGNC: 3188 AceView: EED Ensembl:ENSG00000074266 euGenes: HUgn8726
    ECgene: EED H-InvDB: EED

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for EED Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for EED gene:
    Search GeneIP for patents involving EED

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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