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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EED Gene

protein-coding   GIFtS: 56
GCID: GC11P085955

Embryonic Ectoderm Development

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Embryonic Ectoderm Development1 2     Polycomb Protein EED2
WD Protein Associating With Integrin Cytoplasmic Tails 11 2 3     WAIT-13
WAIT12 5     hEED3
HEED2     

External Ids:    HGNC: 31881   Entrez Gene: 87262   Ensembl: ENSG000000742667   OMIM: 6059845   UniProtKB: O755303   

Export aliases for EED gene to outside databases

Previous GC identifers: GC11P088282 GC11P087494 GC11P086178 GC11P085682 GC11P085633 GC11P082243


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for EED Gene:
This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein
complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell
generations. This protein interacts with enhancer of zeste 2, the cytoplasmic tail of integrin beta7,
immunodeficiency virus type 1 (HIV-1) MA protein, and histone deacetylase proteins. This protein mediates
repression of gene activity through histone deacetylation, and may act as a specific regulator of integrin
function. Two transcript variants encoding distinct isoforms have been identified for this gene. (provided by
RefSeq, Jul 2008)

GeneCards Summary for EED Gene: 
EED (embryonic ectoderm development) is a protein-coding gene. Diseases associated with EED include fainting, and acute promyelocytic leukemia. GO annotations related to this gene include histone methyltransferase activity and identical protein binding.

UniProtKB/Swiss-Prot: EED_HUMAN, O75530
Function: Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and
'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes
'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on
nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the
propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA
methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2
complex include HOXC8, HOXA9, MYT1 and CDKN2A

Gene Wiki entry for EED Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_167190.1  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EED gene promoter:
         p53   GATA-3   Pax-2   Pax-2a   GATA-2   Pax-2b   FOXJ2 (long isoform)   Chx10   Msx-1   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEED promoter sequence
   Search SABiosciences Chromatin IP Primers for EED

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EED


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q14.2-q22.3   Ensembl cytogenetic band:  11q14.2   HGNC cytogenetic band: 11q14.2-q22.3

EED Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EED gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P085955:  view genomic region     (about GC identifiers)

Start:
85,955,586 bp from pter      End:
85,989,855 bp from pter
Size:
34,270 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: EED_HUMAN, O75530 (See protein sequence)
Recommended Name: Polycomb protein EED  
Size: 441 amino acids; 50198 Da
Subunit: Interacts with KMT2A/MLL1 (By similarity). Component of the PRC2/EED-EZH2 complex, which includes EED,
EZH2, SUZ12, RBBP4 and RBBP7 and possibly AEBP2. The minimum components required for methyltransferase activity
of the PRC2/EED-EZH2 complex are EED, EZH2 and SUZ12. Component of the PRC2/EED-EZH1 complex, which includes EED,
EZH1, SUZ12, RBBP4 and AEBP2. The PRC2 complex may also interact with DNMT1, DNMT3A, DNMT3B and PHF1 via the EZH2
subunit and with SIRT1 via the SUZ12 subunit. Interacts with HDAC, HDAC2, histone H1 and YY1. May interact with
ITGA4, ITGAE and ITGB7. May interact with the MA protein of HIV-1
Subcellular location: Nucleus. Chromosome. Note=Transiently colocalizes with XIST at inactive X chromosomes
Developmental stage: Expression peaks at the G1/S phase boundary
Caution: Two variants of the PRC2 complex have been described, termed PRC3 and PRC4. Each of the three complexes
may include a different complement of EED isoforms, although the precise sequences of the isoforms in each
complex have not been determined. The PRC2 and PRC4 complexes may also methylate 'Lys-26' of histone H1 in
addition to 'Lys-27' of histone H3 (PubMed:15099518 and PubMed:15684044), although other studies have
demonstrated no methylation of 'Lys-26' of histone H1 by PRC2 (PubMed:16431907)
Sequence caution: Sequence=AAC23685.1; Type=Erroneous initiation; Sequence=AAC68675.1; Type=Erroneous initiation;
6/11 PDB 3D structures from and Proteopedia for EED (see all 11):
3IIW (3D)        3IIY (3D)        3IJ0 (3D)        3IJ1 (3D)        3IJC (3D)        3JPX (3D)    
Secondary accessions: A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7
Alternative splicing, Alternative initiation: 3 isoforms:  O75530-1   O75530-2   O75530-3   

Explore the universe of human proteins at neXtProt for EED: NX_O75530

Explore proteomics data for EED at MOPED 

Post-translational modifications:

  • UniProtKB: Methylated. Binding to histone H1 'Lys-26' promotes mono-, di-, and trimethylation of internal lysines
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O75530

  • EED Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    EED Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_003788.2  NP_694536.1  

    ENSEMBL proteins: 
     ENSP00000263360   ENSP00000431778   ENSP00000315587   ENSP00000338186   ENSP00000436084  
     ENSP00000437318  

    Human Recombinant Protein Products for EED: 
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    Novus Biologicals EED Proteins
    Novus Biologicals EED Lysates
    Sino Biological Recombinant Protein for EED
    Sino Biological Cell Lysate for EED 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for EED 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001739sex chromatin IEA--
    GO:0005634nucleus NAS9584199
    GO:0035098ESC/E(Z) complex IDA15385962
    GO:0045120pronucleus IEA--

    EED for ontologies           About GeneDecksing



    EED Antibody Products: 
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    ThermoFisher Antibody for EED
    LSBio Antibodies in human, mouse, rat for EED 

    Assay Products for EED: 
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    Cloud-Clone Corp. CLIAs for EED


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    WDR: WD repeat domain containing

    4 InterPro protein domains:
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry O75530

    ProtoNet protein and cluster: O75530

    UniProtKB/Swiss-Prot: EED_HUMAN, O75530
    Domain: The WD repeat domain mediates recognition of trimethylated histone peptides at the consensus sequence
    Ala-Arg-Lys-Ser. This is achieved through an aromatic cage encircling the methyllysine, and involving Phe-97,
    Tyr-148 and Tyr-365
    Similarity: Belongs to the WD repeat ESC family
    Similarity: Contains 7 WD repeats


    EED for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EED_HUMAN, O75530
    Function: Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and
    'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes
    'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on
    nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the
    propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA
    methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2
    complex include HOXC8, HOXA9, MYT1 and CDKN2A
    Induction: Expression is induced by E2F1, E2F2 and E2F3

         Genatlas biochemistry entry for EED:
    murine embryonic ectoderm development (eed) homolog,polycomb-group PcG, homology with Drosophila extra sex
    comb,ubiquitously expressed,interacting with EZH2,HDAC proteins and involved in transcriptional repression
    through this interaction

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IEA--
    GO:0005515protein binding IPI16357870
    GO:0042054histone methyltransferase activity IDA15385962
    GO:0042802identical protein binding IPI11124122
         
    EED for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Eed):
     growth/size  hematopoietic system  integument  pigmentation 

    EED for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for EED 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for EED

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EED 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EED 

    miRNA
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    miRTarBase miRNAs that target EED:
    hsa-mir-101 (MIRT004086)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EED
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate EED (see all 14):
    hsa-miR-30c hsa-miR-34c-3p hsa-miR-181c hsa-miR-513a-3p hsa-miR-499-3p hsa-miR-30d hsa-miR-181a hsa-miR-181d
    SwitchGear 3'UTR luciferase reporter plasmidEED 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): EED (NM_003797)
    Sino Biological Human cDNA Clone for EED
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for EED

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/145 Interacting proteins for EED (O755301, 2, 3 ENSP000002633604) via UniProtKB, MINT, STRING, and/or I2D (see all 145)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3AP684313, ENSP000003502754I2D: score=1 STRING: ENSP00000350275
    HIST1H3BP684313I2D: score=1 
    HIST1H3CP684313I2D: score=1 
    HIST1H3DP684313I2D: score=1 
    HIST1H3EP684313I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006349regulation of gene expression by genetic imprinting IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0016571histone methylation ----
    GO:0045892negative regulation of transcription, DNA-dependent NAS9584199
    GO:0061087positive regulation of histone H3-K27 methylation IEA--

    EED for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for EED

    Search CenterWatch for drugs/clinical trials and news about EED

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for EED gene (2 alternative transcripts): 
    NM_003797.3  NM_152991.2  

    Unigene Cluster for EED:

    Embryonic ectoderm development
    Hs.503510  [show with all ESTs]
    Unigene Representative Sequence: NM_152991
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263360(uc010rtm.2 uc001pbp.3 uc001pbr.3) ENST00000528180
    ENST00000327320(uc001pbq.3) ENST00000351625 ENST00000534595 ENST00000525244(uc010rtn.1)
    ENST00000533228 ENST00000534564 ENST00000524673 ENST00000527888 ENST00000528250

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EED
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate EED (see all 14):
    hsa-miR-30c hsa-miR-34c-3p hsa-miR-181c hsa-miR-513a-3p hsa-miR-499-3p hsa-miR-30d hsa-miR-181a hsa-miR-181d
    SwitchGear 3'UTR luciferase reporter plasmidEED 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EED

    Additional mRNA sequence: 

    AF070418.1 AF078933.1 AF080227.1 AF099032.1 AK292120.1 AK294133.1 AK301265.1 BC047672.2 
    BC068995.1 U90651.1 

    7 DOTS entries:

    DT.213873  DT.100751944  DT.99988495  DT.95166920  DT.120680451  DT.75121196  DT.97839611 

    24/123 AceView cDNA sequences (see all 123):

    T26911 AI921064 AA635557 BM718903 AI990456 BM665282 AF080227 N50094 
    CA415589 BI855767 AU100108 AI630913 AI419291 BM680764 BE644956 BM998102 
    BI856105 BQ013569 CR616258 BI834870 CA944902 AA384638 AI690903 BC047672 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for EED (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13
    SP1:                                                                                                                    -         
    SP2:                                                                                            -                       -         
    SP3:                                                                                            -                                 
    SP4:                                                                          -     -     -     -                                 
    SP5:                                            -                                                                                 


    ECgene alternative splicing isoforms for EED

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EED expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    EED Expression
    About this image


    See EED Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EED

    SOURCE GeneReport for Unigene cluster: Hs.503510

    UniProtKB/Swiss-Prot: EED_HUMAN, O75530
    Tissue specificity: Expressed in brain, colon, heart, kidney, liver, lung, muscle, ovary, peripheral blood
    leukocytes, pancreas, placenta, prostate, spleen, small intestine, testis, thymus and uterus. Appears to be
    overexpressed in breast and colon cancer

        SABiosciences Expression via Pathway-Focused PCR Arrays including EED: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Polycomb & Trithorax Complexes in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EED

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for EED gene from 9/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Eed1 , 5 embryonic ectoderm development1, 5 92.59(n)1
    100(a)1
      7 (50.42 cM)5
    136261  NM_021876.31  NP_068676.11 
     899546565 
    chicken
    (Gallus gallus)
    Aves EED1 embryonic ectoderm development 85.68(n)
    97.05(a)
      426381  NM_001031376.1  NP_001026547.1 
    lizard
    (Anolis carolinensis)
    Reptilia EED6
    Uncharacterized protein
    92(a)
    1 ↔ 1
    3(200402601-200419283)
    African clawed frog
    (Xenopus laevis)
    Amphibia AJ421945.12   -- 80.66(n)    AJ421945.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.145072 Transcribed sequence with moderate similarity to protein more 76.97(n)    CK028285.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG52023
    escl1
    CG5202-PA1 58(a)
    (best of 2)3
    57.47(n)1
    56.9(a)1
      33B53
    346111  NM_164979.21  NP_723702.11 
    worm
    (Caenorhabditis elegans)
    Secernentea mes-66
    Polycomb protein mes-6
    22(a)
    1 ↔ 1
    IV(8511284-8513476)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons FIE1 polycomb group protein FERTILIZATION-INDEPENDENT ENDOSPERM 51.99(n)
    43.15(a)
      821622  NM_112965.1  NP_188710.1 
    rice
    (Oryza sativa)
    Liliopsida Os08g01371001 hypothetical protein 52.94(n)
    46.18(a)
      4344620  NM_001067488.1  NP_001060953.1 


    ENSEMBL Gene Tree for EED (if available)
    TreeFam Gene Tree for EED (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for EED gene

    EED for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for EED
    PGOHUM00000245982 PGOHUM00000242049


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/834 SNPs in EED are shown (see all 834)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1908071601,2
    --85822071(+) CCCCAC/TTCCTT 2 -- us2k10--------
    rs1830061471,2
    --85822083(+) CTGTAA/CTTTGG 2 -- us2k10--------
    rs788132741,2
    C--85822114(+) CTATTG/ATGATA 2 -- us2k13Minor allele frequency- A:0.15NA WA EA 240
    rs1872604211,2
    --85822135(+) CTATCA/CAAATA 2 -- us2k10--------
    rs1927515121,2
    --85822158(+) GTGTTC/TCTTAC 2 -- us2k10--------
    rs1416472171,2
    --85822217(+) CGTAGC/TAATAT 2 -- us2k10--------
    rs1153403211,2
    F--85822313(+) TTTTTG/ACTTTG 2 -- us2k11Minor allele frequency- A:0.06WA 118
    rs771907901,2
    C,F--85822529(+) CTTTGT/CTGGGA 2 -- us2k11Minor allele frequency- C:0.16WA 118
    rs79524811,2
    C,F,A--85822608(+) ACTTTC/GTCAGG 2 -- us2k111Minor allele frequency- G:0.37NA WA CSA EA 373
    rs1461116101,2
    C--85822686(+) GGAAGC/TACTGA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for EED (85955586 - 85989855 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for EED:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv513328CNV Insertion21212237
    esv1712509CNV Insertion17803354
    esv2542002CNV Insertion19546169
    nsv508643CNV Loss20534489
    nsv898055CNV Loss21882294
    nsv832223CNV Loss17160897


    Human Gene Mutation Database (HGMD): EED
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing EED
    DNA2.0 Custom Variant and Variant Library Synthesis for EED

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605984    OMIM disorders: --

    9 diseases for EED:    About MalaCards
    fainting    acute promyelocytic leukemia    ulcerative colitis    prostate cancer
    hodgkin's lymphoma    colon cancer    prostatitis    leukemia
    hepatitis


    EED for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for EED gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer 4.66 1 17134822 (1)
    tumors 0 1 20444294 (1)


    Export disorders for EED gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EED gene, integrated from 9 sources (see all 89):
    (articles sorted by number of sources associating them with EED)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human WD repeat protein WAIT-1 specifically interacts with the cytoplasmic tails of beta7-integrins. (PubMed id 9765275)1, 2, 3, 9 Rietzler M.... Holzmann B. (1998)
    2. The murine Polycomb-group gene eed and its human orthologue: functional implications of evolutionary conservation. (PubMed id 9806832)1, 2, 3, 9 Schumacher A.... Magnuson T. (1998)
    3. Substrate preferences of the EZH2 histone methyltransferase complex. (PubMed id 16431907)1, 2, 9 Martin C.... Zhang Y. (2006)
    4. Characterization of interactions between the mammalian polycomb-group proteins Enx1/EZH2 and EED suggests the existence of different mammalian polycomb-group protein complexes. (PubMed id 9584199)1, 2, 9 Sewalt R.G.A.B.... Otte A.P. (1998)
    5. Binding of different histone marks differentially reg ulates the activity and specificity of polycomb repressive complex 2 (PRC2). (PubMed id 20974918)1, 2 Xu C....Min J. (2010)
    6. Ezh2 requires PHF1 to efficiently catalyze H3 lysine 27 trimethylation in vivo. (PubMed id 18285464)1, 2 Sarma K....Reinberg D. (2008)
    7. Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms. (PubMed id 19026781)1, 2 Margueron R.... Reinberg D. (2008)
    8. The Polycomb group protein EZH2 directly controls DNA methylation. (PubMed id 16357870)1, 2 Vire E.... Fuks F. (2006)
    9. SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex. (PubMed id 15225548)1, 2 Cao R. and Zhang Y. (2004)
    10. Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity. (PubMed id 15385962)1, 2 Pasini D.... Helin K. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8726 HGNC: 3188 AceView: EED Ensembl:ENSG00000074266 euGenes: HUgn8726
    ECgene: EED H-InvDB: EED

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for EED Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for EED gene:
    Search GeneIP for patents involving EED

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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