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EED Gene

protein-coding GIFtS: 57

GC11P085633

embryonic ectoderm development
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
HEED ^¹, ²
WAIT-1 ^¹, ³
WAIT1 ^², ⁵
hEED ^³

Descriptions
WD protein associating with integrin cytoplasmic tails 1 ^², ³
embryonic ectoderm development ^²

External Ids
HGNC: 3188¹
Entrez Gene: 8726²
UniProtKB: O75530³
Ensembl: ENSG00000074266⁷

Search outside databases for aliases for EED gene

Previous GC identifers: GC11P088282 GC11P087494 GC11P086178 GC11P085682

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for EED:

This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric

protein complexes, which are involved in maintaining the transcriptional repressive state of genes

over successive cell generations. This protein interacts with enhancer of zeste 2, the cytoplasmic

tail of integrin beta7, immunodeficiency virus type 1 (HIV-1) MA protein, and histone deacetylase

proteins. This protein mediates repression of gene activity through histone deacetylation, and may

act as a specific regulator of integrin function. Two transcript variants encoding distinct

isoforms have been identified for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: EED_HUMAN, O75530

Function: Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates

'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target

gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA

methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the

PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A

Gene Wiki entry for EED

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the EED gene

Entrez Gene cytogenetic band: 11q14.2-q22.3 Ensembl cytogenetic band: 11q14.2 HGNC cytogenetic band: 11q14.2-q22.3

EED Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P085633: (about GC identifiers)

Start:	85,633,463 bp from pter
End:	85,667,429 bp from pter
Size:	33,967 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000011.8 NT_033927.7

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: EED_HUMAN, O75530 (See protein sequence)

Recommended Name: Polycomb protein EED

Size: 441 amino acids; 50198 Da

Subunit: Interacts with MLL (By similarity). Component of the PRC2/EED-EZH2 complex, which includes

EED, EZH2, SUZ12, RBBP4 and RBBP7 and possibly AEBP2. The minimum components required for

methyltransferase activity of the PRC2/EED-EZH2 complex are EED, EZH2 and SUZ12. Component of the

PRC2/EED-EZH1 complex, which includes EED, EZH1, SUZ12, RBBP4 and AEBP2. The PRC2 complex may also

interact with DNMT1, DNMT3A, DNMT3B and PHF1 via the EZH2 subunit and with SIRT1 via the SUZ12

subunit. Interacts with HDAC, HDAC2, histone H1 and YY1. May interact with ITGA4, ITGAE and ITGB7.

May interact with the MA protein of HIV-1

Subcellular location: Nucleus. Note=Transiently colocalizes with XIST at inactive X chromosomes

Developmental stage: Expression peaks at the G1/S phase boundary

Caution: Two variants of the PRC2 complex have been described, termed PRC3 and PRC4. Each of the

three complexes may include a different complement of EED isoforms, although the precise sequences

of the isoforms in each complex have not been determined. The PRC2 and PRC4 complexes may also

methylate 'Lys-26' of histone H1 in addition to 'Lys-27' of histone H3 (PubMed:15099518 and

PubMed:15684044), although other studies have demonstrated no methylation of 'Lys-26' of histone

H1 by PRC2 (PubMed:16431907)

Secondary accessions: A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7

Alternative splicing, Alternative initiation: 3 isoforms: O75530-1 O75530-2 O75530-3 (Additional isoforms may be produced by alternative initiation, both from non-canonical start codons upstream of the initiator methionine displayed and from other canonical start codons downstream of that displayed (PubMed:15099518 and PubMed:15684044). The precise sites of translation initiation have not been unambiguously identified)

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_003788.2 NP_694536.1

ENSEMBL proteins:

ENSP00000263360 ENSP00000338186 ENSP00000315587

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (EED)
	Human Recombinant Proteins from Abnova (EED)

OriGene Purified Recombinant Human Proteins (see all 2): EED

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	NAS	9584199

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Antibodies for EED:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for EED
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (EED), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (EED)
	Novus Biologicals Antibodies for EED

Assays for EED:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O75530

ProtoNet protein and cluster: O75530

UniProtKB/Swiss-Prot: EED_HUMAN, O75530

Similarity: Belongs to the WD repeat ESC family

Similarity: Contains 7 WD repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (EED)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (EED)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_152991

Applied Biosystems Silencer® siRNAs for EED

Sigma-Aldrich siRNA for EED

Sigma-Aldrich shRNA for EED

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for EED
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_003797
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_003797
untagged cDNA clones in CMV expression vector (see all 2): NM_003797

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003797

UniProtKB/Swiss-Prot: EED_HUMAN, O75530

Function: Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates

'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target

gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA

methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the

PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A

Induction: Expression is induced by E2F1, E2F2 and E2F3

Genatlas biochemistry entry for EED:

murine embryonic ectoderm development (eed) homolog,polycomb-group PcG, homology with Drosophila

extra sex comb,ubiquitously expressed,interacting with EZH2,HDAC proteins and involved in

transcriptional repression through this interaction

3 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Eed):

growth/size

pigmentation

skin/coat/nails

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016564	transcription repressor activity	NAS	9584199
GO:0042802	identical protein binding	IPI	11124122

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for EED

5/27 Interacting proteins for EED (ENSP00000338186³ O75530¹) via UniProtKB, MINT, and/or STRING (see all 27 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DNMT1	P26358¹	STRING (score=.747) EBI-923794, EBI-719459
DNMT3A	Q9Y6K1¹	STRING (score=.728) EBI-923794, EBI-923653
DDB1	Q16531¹	EBI-923794, EBI-350322
DNMT3B	Q9UBC3¹	EBI-923794, EBI-80125
EED	O75530¹	EBI-923794, EBI-923794

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0016481	negative regulation of transcription	NAS	9584199
GO:0016568	chromatin modification	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for EED

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (EED)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (EED)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_152991

Sigma-Aldrich siRNA for EED

Sigma-Aldrich shRNA for EED

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_003797 NM_152991

REFSEQ mRNAs for EED gene (2 alternative transcripts):

NM_003797.2 NM_152991.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_003797 NM_152991

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_003797
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_003797
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_003797

Additional cDNA sequence:

AF070418.1 AF078933.1 AF080227.1 AF099032.1 AK292120.1 AK294133.1 AK301265.1 BC047672.2

BC068995.1 CR616231.1 CR616258.1 U90651.1

7 DOTS entries:

DT.213873 DT.100751944 DT.99988495 DT.95166920 DT.120680451 DT.75121196 DT.97839611

24/123 AceView cDNA sequences (see all 123 ):

BE644956 AI990456 NM_003797 BI855767 AI921064 BU172591 AA635557 NM_152991

CA415589 BC068995 BG122265 BC047672 BG678915 AI630913 N50094 BM680764

AI270650 BM665282 AA384638 T26911 BM718903 BE546282 AF080227 BU608156

highest scoring ESTs for EED:

AF080227 AA149581 AA228084 AA459955 AA629686 AA635557 AA834057 AA876425 AF070418 AF078933

Unigene Cluster for EED:

Embryonic ectoderm development

Hs.503510 [show with all ESTs]

Unigene Representative Sequence: NM_152991

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for EED (see all 6 )

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	^	2	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9	^	10	^	11a	·	11b	^	12a	·	12b	^	13
SP1:																																							-
SP2:																															-								-
SP3:																															-
SP4:																									-		-		-		-
SP5:															-

About this scheme

ECgene alternative splicing isoforms for EED

3 Ensembl transcripts including schematic representations:

ENST00000263360 ENST00000351625 ENST00000327320

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

EED expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for EED

¹ / ² / ³

5 probe-sets matching EED gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
31853_at²^{, 3}	U95-A	2	1.00	0.94	1.00	1.00	AF080227	1.00	1.00	1.00	1
210656_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF099032	0.80	1.00	0.91	1
209572_s_at²^{, 3}	U133-A	2	1.00	0.91	--	--	AF080227	1.00	1.00	1.00	1
210656_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209572_s_at²	U133Plus2	2	1.00	0.91	--	--	--	--	--	--	--

GeneDecks EED for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.503510
Expression variation in blood from EXPOLDB for EED
UniProtKB/Swiss-Prot: EED_HUMAN, O75530
Tissue specificity: Expressed in brain, colon, heart, kidney, liver, lung, muscle, ovary,
peripheral blood leukocytes, pancreas, placenta, prostate, spleen, small intestine, testis, thymus
and uterus. Appears to be overexpressed in breast and colon cancer

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for EED gene from 5/13 species (see all 13 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	EED¹	--	embryonic ectoderm development	95.77(n) 100(a)	476779 XM_852657.1 XP_857750.1
cow (Bos taurus)	EED¹	--	embryonic ectoderm development	95.99(n) 99.77(a)	404183 NM_001040494.1 NP_001035584.1
rat (Rattus norvegicus)	Eed¹	--	embryonic ectoderm development	93.05(n) 100(a)	293104 XM_214996.4 XP_214996.4
mouse (Mus musculus)	Eed^{1, 5}	7 (47.10 cM)⁵	embryonic ectoderm development^{1, 5}	92.59(n)¹ 100(a)¹	13626¹ NM_021876.2¹ NP_068676.1¹ AK077664⁵ AK087924⁵ (see all 14)
chicken (Gallus gallus)	EED¹	--	embryonic ectoderm development	85.68(n) 97.05(a)	426381 NM_001031376.1 NP_001026547.1

About this table Species with no ortholog for EED

ENSEMBL Gene Tree for EED

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/181 NCBI SNPs in EED are shown (see all 181 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 74)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1391221^1,2	A,C,F,H	85632927(+)	`TTGGAG/CTCTAG`	2	--	ng5¹		11		NS EU EA WA NA	708
	rs1376947^1,2	A,C,F,H	85667914(+)	`AAAAAT/CATTAC`	2	--	ng3¹		11		EU EA WA NA	980
	rs7126298^1,2	F,H	85667924(+)	`CTGCCA/TTTAGA`	2	--	ng3¹		4		EU EA WA	420
--	rs7952481^1,2	A,C	85632070(+)	`ACTTTC/GTCAGG`	2	--	ng5¹		0	--	--	--	--
	rs974144^1,2	A,C,F,H	85646271(-)	`TGACAG/AGAGAA`	2	L/L	syn¹ ese³		9		EU EA WA NA	734
	rs991435^1,2	A,C,F,H,O	85637012(+)	`TAAGTG/CATCAG`	2	--	int¹		13		MN EU EA WA NA	1382
	rs10792842^1,2	A,C,F,H	85645357(+)	`GAGACG/ATTTGT`	2	--	int¹		4		EU EA WA	412
	rs2374721^1,2	A,C,F,H	85635393(+)	`ATTTGG/AAGACC`	2	--	int¹		9		NS EU EA WA	526
	rs6592279^1,2	A,C,F,H	85655648(+)	`GTAAGC/TATCAG`	2	--	int¹		12		EA NA EU WA	1048
	rs10898457^1,2	A,C,F,H	85644712(+)	`TGGGGA/GTAGAG`	2	--	int¹		4		EU EA WA	398

About this table

HapMap Linkage Disequilibrium images for EED (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 605984

1 Novoseek disease relationship for EED gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
prostate cancer	7.70	1	17134822 (1)

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(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/55 PubMed articles for EED gene (see all 55 ):

The human WD repeat protein WAIT-1 specifically interacts with the cytoplasmic tails of beta7-integrins. (PubMed id 9765275)^{1, 2, 3, 4} Rietzler M.... Holzmann B. (1998)
The murine Polycomb-group gene eed and its human orthologue: functional implications of evolutionary conservation. (PubMed id 9806832)^{1, 2, 3, 4} Schumacher A....Magnuson T. (1998)
Characterization of interactions between the mammalian polycomb-group proteins Enx1/EZH2 and EED suggests the existence of different mammalian polycomb-group protein complexes. (PubMed id 9584199)^{1, 3, 4} Sewalt R.G.... Otte A.P. (1998)
The Polycomb group protein EZH2 directly controls DNA methylation. (PubMed id 16357870)^{3, 4} Vire E....Fuks F. (2006)
SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex. (PubMed id 15225548)^{3, 4} Cao R. and Zhang Y. (2004)
Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity. (PubMed id 15385962)^{3, 4} Pasini D....Helin K. (2004)
Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. (PubMed id 12435631)^{3, 4} Kuzmichev A....Reinberg D. (2002)
The polycomb group protein EED interacts with YY1, and both proteins induce neural tissue in Xenopus embryos. (PubMed id 11158321)^{3, 4} Satijn D.P....Otte A.P. (2001)
Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation. (PubMed id 10581039)^{3, 4} van der Vlag J. and Otte A.P. (1999)
HEED, the product of the human homolog of the murine eed gene, binds to the matrix protein of HIV-1. (PubMed id 9880543)^{3, 4} Peytavi R.... Boulanger P. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 8726	HGNC: 3188	AceView: EED	Ensembl:ENSG00000074266	euGenes: HUgn8726
ECgene: EED	H-InvDB: EED

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for EED
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for EED:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for EED-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for EED		Antibodies for EED
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for EED		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
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	shRNA in GFP-retroviral vector

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EED Gene

protein-coding GIFtS: 57

Aliases &
Descriptions
for EED

Summaries
for EED

Genomic Location
for EED

Proteins
for EED

Protein Domains/
Families
for EED

Gene Function
for EED

Pathways & Interactions
for EED

Drugs & Compounds
for EED

Transcripts
for EED

Expression
for EED

Orthologs
for EED

Paralogs
for EED

SNPs/Variants
for EED

Disorders & Mutations
for EED

Medical News
for EED

Publications
for EED

Search for EED

Genome Databases showing EED

Other Databases showing EED

Specialized Databases showing EED

Licensable Technologies
for EED

Services
for EED

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

EED Gene

protein-coding GIFtS: 57

Aliases & Descriptionsfor EED

Summariesfor EED

Genomic Locationfor EED

Proteinsfor EED

Protein Domains/Familiesfor EED

Gene Functionfor EED

Pathways & Interactionsfor EED

Drugs & Compoundsfor EED

Transcriptsfor EED

Expression for EED

Orthologsfor EED

Paralogsfor EED

SNPs/Variantsfor EED

Disorders & Mutationsfor EED

Medical Newsfor EED

Publicationsfor EED

Search for EED

Genome Databases showing EED

Other Databases showing EED

Specialized Databases showing EED

Licensable Technologiesfor EED

Servicesfor EED

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for EED

Summaries
for EED

Genomic Location
for EED

Proteins
for EED

Protein Domains/
Families
for EED

Gene Function
for EED

Pathways & Interactions
for EED

Drugs & Compounds
for EED

Transcripts
for EED

Expression
for EED

Orthologs
for EED

Paralogs
for EED

SNPs/Variants
for EED

Disorders & Mutations
for EED

Medical News
for EED

Publications
for EED

Licensable Technologies
for EED

Services
for EED