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Aliases for EED Gene

Aliases for EED Gene

  • Embryonic Ectoderm Development 2 3 5
  • WD Protein Associating With Integrin Cytoplasmic Tails 1 2 3 4
  • HEED 3 4
  • Embryonic Ectoderm Development Protein 3
  • Polycomb Protein EED 3
  • WAIT-1 4
  • WAIT1 3

External Ids for EED Gene

Previous GeneCards Identifiers for EED Gene

  • GC11P088282
  • GC11P087494
  • GC11P086178
  • GC11P085682
  • GC11P085633
  • GC11P085955
  • GC11P082243

Summaries for EED Gene

Entrez Gene Summary for EED Gene

  • This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein interacts with enhancer of zeste 2, the cytoplasmic tail of integrin beta7, immunodeficiency virus type 1 (HIV-1) MA protein, and histone deacetylase proteins. This protein mediates repression of gene activity through histone deacetylation, and may act as a specific regulator of integrin function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for EED Gene

EED (Embryonic Ectoderm Development) is a Protein Coding gene. Diseases associated with EED include Weaver Syndrome and Anisometropia. Among its related pathways are Cellular Senescence and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include identical protein binding and histone methyltransferase activity.

UniProtKB/Swiss-Prot for EED Gene

  • Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates Lys-9 and Lys-27 of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes Lys-26 trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 Lys-27, whereas H3 Lys-27 recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.

Gene Wiki entry for EED Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EED Gene

Genomics for EED Gene

Regulatory Elements for EED Gene

Enhancers for EED Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G086201 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.1 -41.9 -41944 2.8 HDGF PKNOX1 ATF1 ARNT YY1 ZNF766 ELK1 KLF7 JUNB NCOA1 PICALM RNU6-560P EED HIKESHI CCDC81 FNTAP1 ENSG00000276669
GH11G086171 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.8 -68.4 -68443 9.4 HDGF PKNOX1 FOXA2 CREB3L1 ARNT SIN3A ZNF2 ZNF766 FOS JUNB PICALM RNU6-560P PRSS23 EED CREBZF ENSG00000254699
GH11G086182 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.8 -60.7 -60666 3.8 HDGF PKNOX1 ATF1 ARNT TCF12 ELK1 GATA2 FOS KLF13 NCOA1 PICALM RNU6-560P EED HIKESHI ENSG00000254699
GH11G086206 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.5 -38.7 -38656 1.0 SOX13 CTCF TFAP4 FOXA2 ZMYM3 MAX CEBPG ZNF48 RAD21 TEAD3 EED RNU6-560P HIKESHI PICALM ENSG00000276669 FNTAP1
GH11G086218 1.5 FANTOM5 Ensembl ENCODE 12.1 -25.3 -25261 2.3 HDGF PKNOX1 FOXA2 ATF1 MLX WRNIP1 SIN3A YBX1 ZNF48 YY1 HIKESHI EED PICALM RNU6-560P CCDC81 ENSG00000276669
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EED on UCSC Golden Path with GeneCards custom track

Promoters for EED Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000042965 756 2601 HNRNPUL1 PKNOX1 CREB3L1 ARNT ZFP64 WRNIP1 ARID4B SIN3A FEZF1 DMAP1

Genomic Location for EED Gene

Chromosome:
11
Start:
86,244,544 bp from pter
End:
86,285,420 bp from pter
Size:
40,877 bases
Orientation:
Plus strand

Genomic View for EED Gene

Genes around EED on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EED Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EED Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EED Gene

Proteins for EED Gene

  • Protein details for EED Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75530-EED_HUMAN
    Recommended name:
    Polycomb protein EED
    Protein Accession:
    O75530
    Secondary Accessions:
    • A8K7V5
    • O00149
    • Q6NTH2
    • Q7LDA5
    • Q7LDG8
    • Q86VV2
    • Q9UNY7

    Protein attributes for EED Gene

    Size:
    441 amino acids
    Molecular mass:
    50198 Da
    Quaternary structure:
    • Interacts with KMT2A/MLL1 (By similarity). Component of the PRC2/EED-EZH2 complex, which includes EED, EZH2, SUZ12, RBBP4 and RBBP7 and possibly AEBP2. The minimum components required for methyltransferase activity of the PRC2/EED-EZH2 complex are EED, EZH2 and SUZ12. Component of the PRC2/EED-EZH1 complex, which includes EED, EZH1, SUZ12, RBBP4 and AEBP2. The PRC2 complex may also interact with DNMT1, DNMT3A, DNMT3B and PHF1 via the EZH2 subunit and with SIRT1 via the SUZ12 subunit. Interacts with HDAC, HDAC2, histone H1 and YY1. May interact with ITGA4, ITGAE and ITGB7. Interacts with CDYL. May interact with the MA protein of HIV-1. Interacts with ARNTL/BMAL1.
    SequenceCaution:
    • Sequence=AAC23685.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAC68675.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for EED Gene

    Alternative splice isoforms for EED Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EED Gene

Post-translational modifications for EED Gene

  • Methylated. Binding to histone H1 Lys-26 promotes mono-, di-, and trimethylation of internal lysines.
  • Ubiquitination at isoforms=2, 3275
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for EED

No data available for DME Specific Peptides for EED Gene

Domains & Families for EED Gene

Protein Domains for EED Gene

Suggested Antigen Peptide Sequences for EED Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75530

UniProtKB/Swiss-Prot:

EED_HUMAN :
  • The WD repeat domain mediates recognition of trimethylated histone peptides at the consensus sequence Ala-Arg-Lys-Ser. This is achieved through an aromatic cage encircling the methyllysine, and involving Phe-97, Tyr-148 and Tyr-365.
  • Belongs to the WD repeat ESC family.
Domain:
  • The WD repeat domain mediates recognition of trimethylated histone peptides at the consensus sequence Ala-Arg-Lys-Ser. This is achieved through an aromatic cage encircling the methyllysine, and involving Phe-97, Tyr-148 and Tyr-365.
Family:
  • Belongs to the WD repeat ESC family.
genes like me logo Genes that share domains with EED: view

Function for EED Gene

Molecular function for EED Gene

GENATLAS Biochemistry:
murine embryonic ectoderm development (eed) homolog,polycomb-group PcG, homology with Drosophila extra sex comb,ubiquitously expressed,interacting with EZH2,HDAC proteins and involved in transcriptional repression through this interaction
UniProtKB/Swiss-Prot Function:
Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates Lys-9 and Lys-27 of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes Lys-26 trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 Lys-27, whereas H3 Lys-27 recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.
UniProtKB/Swiss-Prot Induction:
Expression is induced by E2F1, E2F2 and E2F3.

Gene Ontology (GO) - Molecular Function for EED Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0005515 protein binding IPI 16357870
GO:0042054 contributes_to histone methyltransferase activity IDA,IMP 28229514
GO:0042802 identical protein binding IPI 11124122
genes like me logo Genes that share ontologies with EED: view
genes like me logo Genes that share phenotypes with EED: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for EED
  • Applied Biological Materials Clones for EED

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EED Gene

Localization for EED Gene

Subcellular locations from UniProtKB/Swiss-Prot for EED Gene

Nucleus. Chromosome. Note=Transiently colocalizes with XIST at inactive X chromosomes.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EED gene
Compartment Confidence
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for EED Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001739 sex chromatin IEA --
GO:0005634 nucleus NAS 9584199
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with EED: view

Pathways & Interactions for EED Gene

genes like me logo Genes that share pathways with EED: view

Gene Ontology (GO) - Biological Process for EED Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006349 regulation of gene expression by genetic imprinting IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0016569 covalent chromatin modification IEA --
genes like me logo Genes that share ontologies with EED: view

No data available for SIGNOR curated interactions for EED Gene

Drugs & Compounds for EED Gene

No Compound Related Data Available

Transcripts for EED Gene

Unigene Clusters for EED Gene

Embryonic ectoderm development:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for EED
  • Applied Biological Materials Clones for EED

Alternative Splicing Database (ASD) splice patterns (SP) for EED Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13
SP1: -
SP2: - -
SP3: -
SP4: - - - -
SP5: -
SP6: - - - - - - - - - -

Relevant External Links for EED Gene

GeneLoc Exon Structure for
EED
ECgene alternative splicing isoforms for
EED

Expression for EED Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EED Gene

Protein differential expression in normal tissues from HIPED for EED Gene

This gene is overexpressed in Plasma (38.2) and Testis (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EED Gene



Protein tissue co-expression partners for EED Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EED Gene:

EED

SOURCE GeneReport for Unigene cluster for EED Gene:

Hs.503510

mRNA Expression by UniProt/SwissProt for EED Gene:

O75530-EED_HUMAN
Tissue specificity: Expressed in brain, colon, heart, kidney, liver, lung, muscle, ovary, peripheral blood leukocytes, pancreas, placenta, prostate, spleen, small intestine, testis, thymus and uterus. Appears to be overexpressed in breast and colon cancer.

Evidence on tissue expression from TISSUES for EED Gene

  • Nervous system(4.3)
  • Liver(4.2)
  • Lung(4.2)
  • Spleen(4.2)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with EED: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for EED Gene

Orthologs for EED Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EED Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia EED 35
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EED 35
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EED 34 35
  • 95.99 (n)
dog
(Canis familiaris)
Mammalia EED 34 35
  • 95.77 (n)
rat
(Rattus norvegicus)
Mammalia Eed 34
  • 93.05 (n)
mouse
(Mus musculus)
Mammalia Eed 34 16 35
  • 92.59 (n)
chicken
(Gallus gallus)
Aves EED 34 35
  • 85.68 (n)
lizard
(Anolis carolinensis)
Reptilia EED 35
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eed 34
  • 79.82 (n)
Str.6112 34
zebrafish
(Danio rerio)
Actinopterygii eed 34 35
  • 74.55 (n)
Dr.14507 34
fruit fly
(Drosophila melanogaster)
Insecta CG5202 36
  • 58 (a)
escl 34 35
  • 57.4 (n)
esc 36 35
  • 55 (a)
worm
(Caenorhabditis elegans)
Secernentea mes-6 35
  • 22 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons FIE 34
  • 52.52 (n)
rice
(Oryza sativa)
Liliopsida Os08g0137100 34
  • 53.43 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6528 35
  • 60 (a)
OneToOne
Species where no ortholog for EED was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EED Gene

ENSEMBL:
Gene Tree for EED (if available)
TreeFam:
Gene Tree for EED (if available)

Paralogs for EED Gene

Pseudogenes.org Pseudogenes for EED Gene

genes like me logo Genes that share paralogs with EED: view

No data available for Paralogs for EED Gene

Variants for EED Gene

Sequence variations from dbSNP and Humsavar for EED Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000025209 -- 86,267,800(+) AGTAG(A/C)GATGG intron-variant
rs1000070799 -- 86,281,218(+) GAATG(C/T)GAGGA intron-variant, nc-transcript-variant
rs1000112460 -- 86,249,456(+) TAAAT(A/C/T)TTTTC intron-variant
rs1000307968 -- 86,244,500(+) GCGCA(A/G)GAGTA upstream-variant-2KB, utr-variant-5-prime
rs1000345066 -- 86,261,476(+) CAGCT(C/T)TTGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EED Gene

Variant ID Type Subtype PubMed ID
esv1712509 CNV insertion 17803354
esv2542002 CNV insertion 19546169
esv3627083 CNV gain 21293372
nsv508643 CNV deletion 20534489
nsv513328 CNV insertion 21212237
nsv832223 CNV loss 17160897

Variation tolerance for EED Gene

Residual Variation Intolerance Score: 27% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.43; 9.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EED Gene

Human Gene Mutation Database (HGMD)
EED
SNPedia medical, phenotypic, and genealogical associations of SNPs for
EED

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EED Gene

Disorders for EED Gene

MalaCards: The human disease database

(3) MalaCards diseases for EED Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
weaver syndrome
  • weaver-like syndrome
anisometropia
hiv-1
  • aids, slow progression to
- elite association - COSMIC cancer census association via MalaCards
Search EED in MalaCards View complete list of genes associated with diseases

Relevant External Links for EED

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EED
genes like me logo Genes that share disorders with EED: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EED Gene

Publications for EED Gene

  1. The human WD repeat protein WAIT-1 specifically interacts with the cytoplasmic tails of beta7-integrins. (PMID: 9765275) Rietzler M. … Holzmann B. (J. Biol. Chem. 1998) 2 3 4 22 64
  2. The murine Polycomb-group gene eed and its human orthologue: functional implications of evolutionary conservation. (PMID: 9806832) Schumacher A. … Magnuson T. (Genomics 1998) 2 3 4 22 64
  3. Substrate preferences of the EZH2 histone methyltransferase complex. (PMID: 16431907) Martin C. … Zhang Y. (J. Biol. Chem. 2006) 3 4 22 64
  4. Characterization of interactions between the mammalian polycomb-group proteins Enx1/EZH2 and EED suggests the existence of different mammalian polycomb-group protein complexes. (PMID: 9584199) Sewalt R.G.A.B. … Otte A.P. (Mol. Cell. Biol. 1998) 3 4 22 64
  5. Corepressor protein CDYL functions as a molecular bridge between polycomb repressor complex 2 and repressive chromatin mark trimethylated histone lysine 27. (PMID: 22009739) Zhang Y. … Liang J. (J. Biol. Chem. 2011) 3 4 64

Products for EED Gene

  • Addgene plasmids for EED

Sources for EED Gene

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