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Aliases for EDRF1 Gene

Aliases for EDRF1 Gene

  • Erythroid Differentiation Regulatory Factor 1 2 3 5
  • C10orf137 3 4
  • Erythroid Differentiation-Related Factor 1 2
  • Chromosome 10 Open Reading Frame 137 2

External Ids for EDRF1 Gene

Previous HGNC Symbols for EDRF1 Gene

  • C10orf137

Previous GeneCards Identifiers for EDRF1 Gene

  • GC10P127450
  • GC10P126982
  • GC10P127409

Summaries for EDRF1 Gene

Entrez Gene Summary for EDRF1 Gene

  • This gene may play a role in erythroid cell differentiation. The encoded protein inhibits DNA binding of the erythroid transcription factor GATA-1 and may regulate the expression of alpha-globin and gamma-globin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

GeneCards Summary for EDRF1 Gene

EDRF1 (Erythroid Differentiation Regulatory Factor 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for EDRF1 Gene

  • Transcription factor involved in erythroid differentiation. Involved in transcriptional activation of the globin gene.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EDRF1 Gene

Genomics for EDRF1 Gene

Regulatory Elements for EDRF1 Gene

Promoters for EDRF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EDRF1 on UCSC Golden Path with GeneCards custom track

Genomic Location for EDRF1 Gene

Chromosome:
10
Start:
125,719,515 bp from pter
End:
125,764,143 bp from pter
Size:
44,629 bases
Orientation:
Plus strand

Genomic View for EDRF1 Gene

Genes around EDRF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EDRF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EDRF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EDRF1 Gene

Proteins for EDRF1 Gene

  • Protein details for EDRF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3B7T1-EDRF1_HUMAN
    Recommended name:
    Erythroid differentiation-related factor 1
    Protein Accession:
    Q3B7T1
    Secondary Accessions:
    • B2RC65
    • Q3KR40
    • Q4G190
    • Q5VZQ4
    • Q8IZ74
    • Q9Y3W4

    Protein attributes for EDRF1 Gene

    Size:
    1238 amino acids
    Molecular mass:
    138528 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAG37462.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH73214.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for EDRF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EDRF1 Gene

Proteomics data for EDRF1 Gene at MOPED

Post-translational modifications for EDRF1 Gene

  • Ubiquitination at Lys 178 and Lys 694
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for EDRF1 Gene

Domains & Families for EDRF1 Gene

Protein Domains for EDRF1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for EDRF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q3B7T1

UniProtKB/Swiss-Prot:

EDRF1_HUMAN :
  • Contains 2 TPR repeats.
Similarity:
  • Contains 2 TPR repeats.
genes like me logo Genes that share domains with EDRF1: view

No data available for Gene Families for EDRF1 Gene

Function for EDRF1 Gene

Molecular function for EDRF1 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor involved in erythroid differentiation. Involved in transcriptional activation of the globin gene.
genes like me logo Genes that share phenotypes with EDRF1: view

miRNA for EDRF1 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EDRF1 Gene

Localization for EDRF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EDRF1 Gene

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for EDRF1 Gene

Pathways & Interactions for EDRF1 Gene

SuperPathways for EDRF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for EDRF1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for EDRF1 Gene

Drugs & Compounds for EDRF1 Gene

No Compound Related Data Available

Transcripts for EDRF1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for EDRF1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17a ·
SP1: - -
SP2:
SP3:
SP4: -
SP5: -
SP6: - -
SP7:
SP8:
SP9:
SP10:

ExUns: 17b ^ 18a · 18b ^ 19a · 19b · 19c ^ 20 ^ 21 ^ 22a · 22b · 22c
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10: -

Relevant External Links for EDRF1 Gene

GeneLoc Exon Structure for
EDRF1
ECgene alternative splicing isoforms for
EDRF1

Expression for EDRF1 Gene

mRNA expression in normal human tissues for EDRF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for EDRF1 Gene

This gene is overexpressed in Salivary gland (26.5), Testis (17.6), Ovary (17.6), and Adipocyte (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for EDRF1 Gene



genes like me logo Genes that share expression patterns with EDRF1: view

Protein tissue co-expression partners for EDRF1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EDRF1 Gene

Orthologs for EDRF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for EDRF1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C26H10orf137 35
  • 90.32 (n)
  • 95.21 (a)
EDRF1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C28H10orf137 35
  • 91.56 (n)
  • 95.94 (a)
EDRF1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Edrf1 35
  • 88.04 (n)
  • 93.72 (a)
Edrf1 16
2700050L05Rik 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C10H10orf137 35
  • 99.57 (n)
  • 99.92 (a)
EDRF1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1306820 35
  • 87.95 (n)
  • 93.88 (a)
oppossum
(Monodelphis domestica)
Mammalia EDRF1 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EDRF1 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves C6H10ORF137 35
  • 79.73 (n)
  • 87.41 (a)
EDRF1 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EDRF1 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497935 35
  • 72.05 (n)
  • 77.76 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC566404 35
  • 65.99 (n)
  • 71.69 (a)
EDRF1 36
  • 69 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001324 35
  • 46.99 (n)
  • 41.34 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6511 35
  • 47.76 (n)
  • 41.72 (a)
CG6511 36
  • 34 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToOne
Species with no ortholog for EDRF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EDRF1 Gene

ENSEMBL:
Gene Tree for EDRF1 (if available)
TreeFam:
Gene Tree for EDRF1 (if available)

Paralogs for EDRF1 Gene

genes like me logo Genes that share paralogs with EDRF1: view

No data available for Paralogs for EDRF1 Gene

Variants for EDRF1 Gene

Sequence variations from dbSNP and Humsavar for EDRF1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
VAR_035862 A colorectal cancer sample
VAR_035863 A colorectal cancer sample
rs943633 -- 125,754,806(-) AATGG(G/T)TGTCA intron-variant
rs1384611 -- 125,738,548(+) GCATT(A/G)AGAAA intron-variant
rs2008028 -- 125,754,130(+) AGACT(C/T)GCTTG intron-variant

Variation tolerance for EDRF1 Gene

Residual Variation Intolerance Score: 1.91% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.71; 73.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EDRF1 Gene

HapMap Linkage Disequilibrium report
EDRF1
Human Gene Mutation Database (HGMD)
EDRF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for EDRF1 Gene

Disorders for EDRF1 Gene

Relevant External Links for EDRF1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EDRF1

No disorders were found for EDRF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EDRF1 Gene

Publications for EDRF1 Gene

  1. A novel erythroid differentiation related gene EDRF1 upregulating globin gene expression in HEL cells. (PMID: 12609092) Wang D. … Shen B. (Chin. Med. J. 2002) 2 3 4 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland S.L. … Hayden M.R. (Hum. Mol. Genet. 2014) 3
  4. A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. (PMID: 25036637) Taipale M. … Lindquist S. (Cell 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for EDRF1 Gene

Sources for EDRF1 Gene

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