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Aliases for EDRF1 Gene

Aliases for EDRF1 Gene

  • Erythroid Differentiation Regulatory Factor 1 2 3
  • Erythroid Differentiation-Related Factor 1 2 3
  • C10orf137 3 4
  • Chromosome 10 Open Reading Frame 137 2

External Ids for EDRF1 Gene

Previous HGNC Symbols for EDRF1 Gene

  • C10orf137

Previous GeneCards Identifiers for EDRF1 Gene

  • GC10P127450
  • GC10P126982
  • GC10P127409

Summaries for EDRF1 Gene

Entrez Gene Summary for EDRF1 Gene

  • This gene may play a role in erythroid cell differentiation. The encoded protein inhibits DNA binding of the erythroid transcription factor GATA-1 and may regulate the expression of alpha-globin and gamma-globin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

GeneCards Summary for EDRF1 Gene

EDRF1 (Erythroid Differentiation Regulatory Factor 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for EDRF1 Gene

  • Transcription factor involved in erythroid differentiation. Involved in transcriptional activation of the globin gene.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EDRF1 Gene

Genomics for EDRF1 Gene

Genomic Location for EDRF1 Gene

Start:
125,719,515 bp from pter
End:
125,764,143 bp from pter
Size:
44,629 bases
Orientation:
Plus strand

Genomic View for EDRF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EDRF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EDRF1 Gene

No data available for Regulatory Elements for EDRF1 Gene

Proteins for EDRF1 Gene

  • Protein details for EDRF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3B7T1-EDRF1_HUMAN
    Recommended name:
    Erythroid differentiation-related factor 1
    Protein Accession:
    Q3B7T1
    Secondary Accessions:
    • B2RC65
    • Q3KR40
    • Q4G190
    • Q5VZQ4
    • Q8IZ74
    • Q9Y3W4

    Protein attributes for EDRF1 Gene

    Size:
    1238 amino acids
    Molecular mass:
    138528 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAG37462.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH73214.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for EDRF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EDRF1 Gene

Proteomics data for EDRF1 Gene at MOPED

Post-translational modifications for EDRF1 Gene

  • Ubiquitination at Lys178 and Lys694
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for EDRF1 Gene

Domains for EDRF1 Gene

Protein Domains for EDRF1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for EDRF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q3B7T1

UniProtKB/Swiss-Prot:

EDRF1_HUMAN :
  • Q3B7T1
Similarity:
  • Contains 2 TPR repeats.
genes like me logo Genes that share domains with EDRF1: view

No data available for Gene Families for EDRF1 Gene

Function for EDRF1 Gene

Molecular function for EDRF1 Gene

UniProtKB/Swiss-Prot Function: Transcription factor involved in erythroid differentiation. Involved in transcriptional activation of the globin gene.

Gene Ontology (GO) - Molecular Function for EDRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with EDRF1: view

Phenotypes for EDRF1 Gene

GenomeRNAi human phenotypes for EDRF1:
genes like me logo Genes that share phenotypes with EDRF1: view

miRNA for EDRF1 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for EDRF1 Gene

Localization for EDRF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EDRF1 Gene

Gene Ontology (GO) - Cellular Components for EDRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with EDRF1: view

No data available for Subcellular locations from COMPARTMENTS for EDRF1 Gene

Pathways for EDRF1 Gene

SuperPathways for EDRF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for EDRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with EDRF1: view

No data available for Pathways by source for EDRF1 Gene

Transcripts for EDRF1 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EDRF1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for EDRF1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EDRF1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17a ·
SP1: - -
SP2:
SP3:
SP4: -
SP5: -
SP6: - -
SP7:
SP8:
SP9:
SP10:

ExUns: 17b ^ 18a · 18b ^ 19a · 19b · 19c ^ 20 ^ 21 ^ 22a · 22b · 22c
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10: -

Relevant External Links for EDRF1 Gene

GeneLoc Exon Structure for
EDRF1
ECgene alternative splicing isoforms for
EDRF1

Expression for EDRF1 Gene

mRNA expression in normal human tissues for EDRF1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for EDRF1 Gene

genes like me logo Genes that share expressions with EDRF1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EDRF1 Gene

Orthologs for EDRF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for EDRF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C10H10orf137 35
  • 99.57 (n)
  • 99.92 (a)
EDRF1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C26H10orf137 35
  • 90.32 (n)
  • 95.21 (a)
EDRF1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C28H10orf137 35
  • 91.56 (n)
  • 95.94 (a)
EDRF1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 2700050L05Rik 16
2700050L05Rik 36
  • 93 (a)
OneToOne
Edrf1 35
  • 88.04 (n)
  • 93.72 (a)
oppossum
(Monodelphis domestica)
Mammalia EDRF1 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EDRF1 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1306820 35
  • 87.95 (n)
  • 93.88 (a)
chicken
(Gallus gallus)
Aves C6H10ORF137 35
  • 79.73 (n)
  • 87.41 (a)
EDRF1 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EDRF1 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497935 35
  • 72.05 (n)
  • 77.76 (a)
zebrafish
(Danio rerio)
Actinopterygii EDRF1 36
  • 69 (a)
OneToOne
LOC566404 35
  • 65.99 (n)
  • 71.69 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001324 35
  • 46.99 (n)
  • 41.34 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6511 35
  • 47.76 (n)
  • 41.72 (a)
CG6511 36
  • 34 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToOne
Species with no ortholog for EDRF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EDRF1 Gene

ENSEMBL:
Gene Tree for EDRF1 (if available)
TreeFam:
Gene Tree for EDRF1 (if available)

Paralogs for EDRF1 Gene

genes like me logo Genes that share paralogs with EDRF1: view

No data available for Paralogs for EDRF1 Gene

Variants for EDRF1 Gene

Sequence variations from dbSNP and Humsavar for EDRF1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs943633 -- 125,754,806(-) AATGG(G/T)TGTCA intron-variant
rs1384611 -- 125,738,548(+) GCATT(A/G)AGAAA intron-variant
rs2008028 -- 125,754,130(+) AGACT(C/T)GCTTG intron-variant
rs2277211 -- 125,740,332(-) TGCTT(C/T)ACTGC intron-variant
rs2296830 -- 125,763,971(-) AGCTC(A/G)TCTTT utr-variant-3-prime, nc-transcript-variant, intron-variant

Relevant External Links for EDRF1 Gene

HapMap Linkage Disequilibrium report
EDRF1
Human Gene Mutation Database (HGMD)
EDRF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for EDRF1 Gene

Disorders for EDRF1 Gene

No disorders were found for EDRF1 Gene.

No data available for UniProtKB/Swiss-Prot for EDRF1 Gene

Publications for EDRF1 Gene

  1. A novel erythroid differentiation related gene EDRF1 upregulating globin gene expression in HEL cells. (PMID: 12609092) Wang D. … Shen B. (Chin. Med. J. 2002) 2 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Initial function analysis of a novel erythroid differentiation related gene EDRF1. (PMID: 18726394) Wang D. … Shen B. (Sci. China, C, Life Sci. 2001) 3
  5. Antisense EDRF1 gene inhibited GATA-1 transcription factor DNA-binding activity in K562 cells. (PMID: 18759052) Wang D. … Shen B. (Sci. China, C, Life Sci. 2002) 3

Products for EDRF1 Gene

Sources for EDRF1 Gene

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