Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



EDNRB Gene

protein-coding   GIFtS: 71
GCID: GC13M078469

Endothelin Receptor Type B


(Previous symbols: HSCR2, HSCR)
  See EDNRB-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Endothelin Receptor Type B1 2     ETRB2 3
HSCR21 2 5     ABCDS2 5
HSCR1 2     WS4A2 5
Endothelin Receptor Non-Selective Type2 3     ETB2
ET-B2 3     ETBR2
ET-BR2 3     Endothelin B Receptor2

External Ids:    HGNC: 31801   Entrez Gene: 19102   Ensembl: ENSG000001361607   OMIM: 1312445   UniProtKB: P245303   

Export aliases for EDNRB gene to outside databases

Previous GC identifers: GC13M076437 GC13M072464 GC13M077406 GC13M076267 GC13M077367 GC13M059168


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for EDNRB Gene:
The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium
second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1,
ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in
the endothelin receptor type B gene. Alternatively spliced transcript variants encoding different isoforms have
been found for this gene. (provided by RefSeq, Jan 2011)

GeneCards Summary for EDNRB Gene:
EDNRB (endothelin receptor type B) is a protein-coding gene. Diseases associated with EDNRB include hirschsprung disease type 2, and ednrb-related hirschsprung disease. GO annotations related to this gene include peptide hormone binding and endothelin receptor activity. An important paralog of this gene is EDNRA.

UniProtKB/Swiss-Prot: EDNRB_HUMAN, P24530
Function: Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins
that activate a phosphatidylinositol-calcium second messenger system

summary for EDNRB Gene:
The endothelin B receptor (ETB receptor) is a member of the endothelin receptor group of G-protein-coupled
receptors that also includes ETA. They are located primarily in the vascular endothelial cells where they
play a role in vasoconstriction, vasodilation, bronchoconstriction and cell proliferation. The human ETB
receptor gene has been localized to chromosome 13 (13q22).

Gene Wiki entry for EDNRB (Endothelin receptor type B) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NT_024524.15  NC_018924.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the EDNRB gene promoter:
         AP-1   ATF-2   c-Jun   NF-kappaB1   NF-kappaB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): EDNRB promoter sequence
   Search Chromatin IP Primers for EDNRB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EDNRB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q22   Ensembl cytogenetic band:  13q22.3   HGNC cytogenetic band: 13q22

EDNRB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EDNRB gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M078469:  view genomic region     (about GC identifiers)

Start:
78,469,616 bp from pter      End:
78,493,903 bp from pter
Size:
24,288 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: EDNRB_HUMAN, P24530 (See protein sequence)
Recommended Name: Endothelin B receptor precursor  
Size: 442 amino acids; 49644 Da
Sequence caution: Sequence=BAD92435.1; Type=Erroneous initiation;
Secondary accessions: A2A2Z8 A8K3T4 O15343 Q59GB1 Q5W0G9 Q8NHM6 Q8NHM7 Q8NHM8 Q8NHM9 Q9UD23
Q9UQK3
Alternative splicing: 3 isoforms:  P24530-1   P24530-2   P24530-3   (Ref.10 (AAD24541) sequence is in conflict in positions: 79:SGHRTP->RPPDA)

Explore the universe of human proteins at neXtProt for EDNRB: NX_P24530

Explore proteomics data for EDNRB at MOPED

Post-translational modifications: 

  • Palmitoylation of Cys-402 was confirmed by the palmitoylation of Cys-402 in a deletion mutant lacking both Cys-403
    and Cys-4051
  • Glycosylation2 at Asn59
  • Modification sites at PhosphoSitePlus

  • See EDNRB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_000106.1  NP_001116131.1  NP_001188326.1  NP_003982.1  

    ENSEMBL proteins: 
     ENSP00000366416   ENSP00000335311   ENSP00000403401  
    Reactome Protein details: P24530

    EDNRB Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for EDNRB
    OriGene Protein Over-expression Lysate for EDNRB
    OriGene MassSpec for EDNRB
    OriGene Custom Protein Services for EDNRB
    GenScript Custom Purified and Recombinant Proteins Services for EDNRB
    Novus Biologicals EDNRB Proteins
    Novus Biologicals EDNRB Lysates
    Sino Biological Recombinant Protein for EDNRB
    Sino Biological Cell Lysate for EDNRB
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for EDNRB 

    EDNRB Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of EDNRB
    R&D Systems Antibodies for EDNRB (EDNRB/Endothelin R Type B)
    OriGene Antibodies for EDNRB
    OriGene Custom Antibody Services for EDNRB
    Novus Biologicals EDNRB Antibodies
    Abcam antibodies for EDNRB
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for EDNRB
    LSBio Antibodies in human, mouse, rat for EDNRB

    EDNRB Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for EDNRB
    Browse R&D Systems for biochemical assays
    GenScript EDNRB-overexpressing Cell Line for Assay
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for EDNRB 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    EDNR: GPCR / Class A : Endothelin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: ETB receptor
    Endothelin receptors

    4 InterPro protein domains:
     IPR001112 ETB_rcpt
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000499 Endthln_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P24530

    ProtoNet protein and cluster: P24530

    2 Blocks protein domains:
    IPB000499 Endothelin receptor signature
    IPB001112 Endothelin-B receptor signature


    UniProtKB/Swiss-Prot: EDNRB_HUMAN, P24530
    Similarity: Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily


    Find genes that share domains with EDNRB           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EDNRB_HUMAN, P24530
    Function: Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins
    that activate a phosphatidylinositol-calcium second messenger system

         Genatlas biochemistry entry for EDNRB:
    endothelin receptor B,G protein coupled receptor superfamily,homologous to murine piebald lethal

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004962endothelin receptor activity IMP19767294
    GO:0005515protein binding IPI--
    GO:0017046peptide hormone binding IPI1713452
    GO:0031702type 1 angiotensin receptor binding IEA--
         
    Find genes that share ontologies with EDNRB           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for EDNRB:
     Increased G2M DNA content  Increased number of mitotic ce  Increased viability after born 

         Selected MGI mutant phenotypes (inferred from 47 alleles(MGI details for Ednrb) (see all 21):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  growth/size/body  hearing/vestibular/ear  homeostasis/metabolism  immune system 
     integument  limbs/digits/tail  mortality/aging  muscle  nervous system 

    Find genes that share phenotypes with EDNRB           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for EDNRB: Ednrbtm1Ywa Ednrbtm1.2Nat Ednrbtm1.1Yko

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EDNRB
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for EDNRB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EDNRB
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EDNRB

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat EDNRB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EDNRB (see all 57):
    hsa-miR-142-5p hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-19b-2* hsa-miR-146a hsa-miR-1224-3p hsa-miR-3616-5p
    SwitchGear 3'UTR luciferase reporter plasmidEDNRB 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for EDNRB
    Predesigned siRNA for gene silencing in human, mouse, rat EDNRB

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for EDNRB

    Clone
    Products:
         
    OriGene clones in human, mouse for EDNRB (see all 20)
    OriGene ORF clones in mouse, rat for EDNRB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): EDNRB (NM_000115)
    Sino Biological Human cDNA Clone for EDNRB
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EDNRB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EDNRB

    Cell Line
    Products:
         
    GenScript EDNRB-overexpressing Cell Line for Assay
    Browse ESI BIO Cell Lines and PureStem Progenitors for EDNRB 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EDNRB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    EDNRB_HUMAN, P24530: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol3
    extracellular2
    mitochondrion2
    nucleus2
    cytoskeleton1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS8810293
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----
    GO:0031965nuclear membrane IEA--

    Find genes that share ontologies with EDNRB           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for EDNRB About   (see all 12)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    Peptide ligand-binding receptors0.60
    2Neuropeptides signaling through G protein alpha i and G protein alpha q
    Peptide GPCRs0.46
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    5Development Angiotensin activation of ERK
    Development EDNRB signaling0.54


    Find genes that share SuperPaths with EDNRB           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for EDNRB
        Endothelin-1 Signaling Pathway

    1 GeneGo (Thomson Reuters) Pathway for EDNRB
        Development EDNRB signaling

    Selected BioSystems Pathways for EDNRB (see all 6)
        Prostaglandin Synthesis and Regulation
    GPCRs, Class A Rhodopsin-like
    Endothelin
    Endothelins
    Arf6 trafficking events


    2 Reactome Pathways for EDNRB
        Peptide ligand-binding receptors
    G alpha (q) signalling events


    3 Kegg Pathways  (Kegg details for EDNRB):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction
    Melanogenesis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including EDNRB: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Hypertension in human mouse rat
              Embryonic Stem Cells in human mouse rat
              Prostate Cancer in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for EDNRB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for EDNRB (P245301, 3 ENSP000003353114) via UniProtKB, MINT, STRING, and/or I2D (see all 140)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EDN1P053051, 3, ENSP000003686834EBI-6624656,EBI-715181 I2D: score=1 STRING: ENSP00000368683
    CAV1Q031353, ENSP000003391914I2D: score=2 STRING: ENSP00000339191
    COPS5Q929053, ENSP000003505124I2D: score=1 STRING: ENSP00000350512
    GRK6P432503, ENSP000003772044I2D: score=1 STRING: ENSP00000377204
    EDN3P141383, ENSP000003371284I2D: score=1 STRING: ENSP00000337128
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 41):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ISS--
    GO:0001755neural crest cell migration IEA--
    GO:0001934positive regulation of protein phosphorylation IEA--
    GO:0006885regulation of pH IEA--
    GO:0007166cell surface receptor signaling pathway TAS8810293

    Find genes that share ontologies with EDNRB           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for EDNRB
      Browse compounds at ApexBio 

    Compounds for EDNRB available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BQ-3020Selective ETB agonist[143113-45-5]
    BQ 788 sodium saltSelective ETB antagonist[156161-89-6]
    Sarafotoxin S6cSelective ETB agonist[121695-87-2]
    IRL-1620Highly selective ETB agonist[142569-99-1]
    IRL-2500Potent ETB antagonist[169545-27-1]

    1 HMDB Compound for EDNRB    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    2 DrugBank Compounds for EDNRB    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    SitaxentanSitaxsentan (see all 2)210421-64-0targetantagonist16335785 7858879 15629255 11752352 9806221 17472992 7921608
    Bosentan-- 147536-97-8targetantagonist16335785 7858879 15629255 11752352 9806221 7921608

    Selected IUPHAR Ligands for EDNRB (ETB receptor) (see all 13)    About this table
    LigandTypeActionAffinityPubmed IDs
    endothelin-3
    AgonistFull agonist9.8 - 11.58460684 7524189 8904635
    [125I]IRL1620
    AgonistFull agonist9.9 - 10.18301559
    [125I]BQ3020
    AgonistFull agonist8.3 - 107881728 8587429 1472961
    [125I]ET-1
    AgonistFull agonist9.2 - 108477528 8460684 7524189 8355464 7620699
    sarafotoxin S6c
    AgonistFull agonist8.8 - 9.88904635 8587419
    BQ 3020
    AgonistFull agonist9.77733918
    [125I][Ala1,3,11,15]ET-1
    AgonistFull agonist9.71472961
    [Ala1,3,11,15]ET-1
    AgonistFull agonist8.7 - 9.21472961
    IRL 1620
    AgonistFull agonist8.71320877
    A192621
    AntagonistAntagonist8.110479298

    Selected Novoseek inferred chemical compound relationships for EDNRB gene (see all 59)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sarafotoxin 90 38 8336519 (3), 9240323 (2), 8751073 (1), 9146666 (1) (see all 26)
    bq788 89.2 31 15906230 (2), 17433294 (2), 15604257 (2), 15358810 (1) (see all 20)
    bq123 88.5 29 7620699 (2), 8309002 (2), 8355464 (2), 8473300 (1) (see all 20)
    bq 3020 84.1 7 7891013 (2), 8355464 (2), 7679333 (1)
    irl 1620 81.2 5 10705994 (1), 15280069 (1), 8650075 (1), 8664342 (1)
    atrasentan 77.4 3 15838329 (2), 15838364 (1)
    fr139317 77.1 4 7891013 (1), 8124808 (1), 7965709 (1)
    bosentan 75.2 10 9786266 (1), 14727963 (1), 9777021 (1), 8035319 (1) (see all 10)
    pd 142893 74.3 1 12147606 (1)
    bq610 72.7 5 17433294 (2), 10445306 (1), 12147606 (1), 11034585 (1)



    Find genes that share compounds with EDNRB           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for EDNRB gene (4 alternative transcripts): 
    NM_000115.3  NM_001122659.2  NM_001201397.1  NM_003991.3  

    Unigene Cluster for EDNRB:

    Endothelin receptor type B
    Hs.82002  [show with all ESTs]
    Unigene Representative Sequence: NM_001201397
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377211(uc001vkp.1 uc001vkq.1) ENST00000334286(uc001vko.2)
    ENST00000475537 ENST00000446573(uc010aez.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat EDNRB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EDNRB (see all 57):
    hsa-miR-142-5p hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-19b-2* hsa-miR-146a hsa-miR-1224-3p hsa-miR-3616-5p
    SwitchGear 3'UTR luciferase reporter plasmidEDNRB 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for EDNRB
    Predesigned siRNA for gene silencing in human, mouse, rat EDNRB
    Clone
    Products:
         
    OriGene clones in human, mouse for EDNRB (see all 20)
    OriGene ORF clones in mouse, rat for EDNRB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): EDNRB (NM_000115)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EDNRB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EDNRB
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for EDNRB
    OriGene qSTAR qPCR primer pairs in human, mouse for EDNRB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EDNRB
      QuantiTect SYBR Green Assays in human, mouse, rat EDNRB
      QuantiFast Probe-based Assays in human, mouse, rat EDNRB

    Additional mRNA sequence: 

    AB209198.1 AF114165.1 AK290699.1 AY275463.1 BC014472.1 D90402.1 L06623.1 M74921.1 
    S44866.1 S57283.1 X99250.1 

    12 DOTS entries:

    DT.100793248  DT.443502  DT.101975883  DT.120795950  DT.100793249  DT.75164588  DT.97817518  DT.100709927 
    DT.95278691  DT.117753  DT.95278689  DT.95278688 

    Selected AceView cDNA sequences (see all 221):

    N24818 BI492017 CR605578 BM804821 CR623558 CA771312 BU727655 BU678277 
    AA814635 AA573116 AF114164 AF308156 AF114163 BI520340 BI962776 CK906282 
    CR608540 AU139933 N20208 AU136164 AI422064 AU137325 AL709106 BQ212073 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    EDNRB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTATGCTGT
    EDNRB Expression
    About this image


    EDNRB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 7 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Oligodendrocyte Precursor Cells Forebrain White Matter
             Cerebellum
             Oligodendrocyte-like cells
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 6 entries
             hIPS1
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 3 entries
             Hindgut
     
     Oligodendrocytes (Nervous System)    fully expand to see all 2 entries
             Oligodendrocyte-like cells
    EDNRB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EDNRB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.82002

    UniProtKB/Swiss-Prot: EDNRB_HUMAN, P24530
    Tissue specificity: Expressed in placental stem villi vessels, but not in cultured placental villi smooth muscle
    cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including EDNRB: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Hypertension in human mouse rat
              Embryonic Stem Cells in human mouse rat
              Prostate Cancer in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for EDNRB
    OriGene qSTAR qPCR primer pairs in human, mouse for EDNRB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EDNRB
    QuantiTect SYBR Green Assays in human, mouse, rat EDNRB
    QuantiFast Probe-based Assays in human, mouse, rat EDNRB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EDNRB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for EDNRB gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ednrb1 , 5 endothelin receptor type B1, 5 85.49(n)1
    89.12(a)1
      14 (53.05 cM)5
    136181  NM_001136061.21  NP_001129533.11 
     1038146255 
    chicken
    (Gallus gallus)
    Aves EDNRB1 endothelin receptor type B 76.96(n)
    85.05(a)
      408082  NM_001001127.1  NP_001001127.1 
    lizard
    (Anolis carolinensis)
    Reptilia EDNRB6
    endothelin receptor type B
    82(a)
    1 ↔ 1
    3(98046582-98070355)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ednrb1 endothelin receptor type B 66.26(n)
    65.04(a)
      779931  NM_001079008.1  NP_001072476.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AF275636.12   -- 74.49(n)   30442  AF275636.1 


    ENSEMBL Gene Tree for EDNRB (if available)
    TreeFam Gene Tree for EDNRB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for EDNRB gene
    EDNRA2  GRPR2  GPR372  BRS32  NMBR2  GPR37L12  
    3 SIMAP similar genes for EDNRB using alignment to 1 protein entry:     EDNRB_HUMAN:
    EDNRA    GRPR    NMBR

    Find genes that share paralogs with EDNRB           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for EDNRB (see all 1523)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0034744
    Hirschsprung disease 2 (HSCR2)4--see VAR_0034742 M I mis40--------
    VAR_0034714
    Hirschsprung disease 2 (HSCR2)4--see VAR_0034712 W C mis40--------
    VAR_0034754
    Hirschsprung disease 2 (HSCR2)4--see VAR_0034752 P L mis40--------
    VAR_0034704
    Waardenburg syndrome 4A (WS4A)4--see VAR_0034702 A G mis40--------
    rs2003636111,2,4
    Hirschsprung disease 2 (HSCR2)4--see VAR_0034732 mis40--------
    VAR_0152944
    Waardenburg syndrome 4A (WS4A)4--see VAR_0152942 F L mis40--------
    rs53521,2,4
    Hirschsprung disease 2 (HSCR2)4--see VAR_0034722 mis40--------
    rs18017101,2,,4
    C,Fother159191277(-) CCAAGG/AGTTCC 8 /S /G mis15Minor allele frequency- A:0.01MN NA EU 6063
    rs1874746331,2
    --59182096(+) AAACAA/GGGCAA 4 -- int10--------
    rs1918768021,2
    --59182236(+) TGAATC/GCTACA 4 -- int10--------

    HapMap Linkage Disequilibrium report for EDNRB (78469616 - 78493903 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for EDNRB:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2747694CNV Deletion23290073
    esv2669442CNV Deletion23128226

    Human Gene Mutation Database (HGMD): EDNRB
    Locus Specific Mutation Databases (LSDB): EDNRB

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing EDNRB
    DNA2.0 Custom Variant and Variant Library Synthesis for EDNRB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 131244   
    OMIM disorders: 600155  600501  277580  
    UniProtKB/Swiss-Prot: EDNRB_HUMAN, P24530
  • Waardenburg syndrome 4A (WS4A) [MIM:277580]: A disorder characterized by the association of Waardenburg
    features (depigmentation and deafness) with the absence of enteric ganglia in the distal part of the intestine
    (Hirschsprung disease). Note=The disease is caused by mutations affecting the gene represented in this entry
  • Hirschsprung disease 2 (HSCR2) [MIM:600155]: A disorder of neural crest development characterized by
    absence of enteric ganglia along a variable length of the intestine. It is the most common cause of congenital
    intestinal obstruction. Early symptoms range from complete acute neonatal obstruction, characterized by vomiting,
    abdominal distention and failure to pass stool, to chronic constipation in the older child. Note=The disease is
    caused by mutations affecting the gene represented in this entry
  • ABCD syndrome (ABCDS) [MIM:600501]: An autosomal recessive syndrome characterized by albinism, black lock
    at temporal occipital region, bilateral deafness, aganglionosis of the large intestine and total absence of
    neurocytes and nerve fibers in the small intestine. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 17 diseases for EDNRB:    
    About MalaCards
    hirschsprung disease type 2    ednrb-related hirschsprung disease    abcd syndrome    waardenburg syndrome type iva
    impetigo    hirschsprung's disease    waardenburg syndrome type 4    dcx-related disorders
    bullous impetigo    acute poststreptococcal glomerulonephritis    subcortical band heterotopia    waardenburg's syndrome
    pachygyria    megacolon    central hypoventilation syndrome    congenital central hypoventilation syndrome
    intestinal obstruction

    7 diseases from the University of Copenhagen DISEASES database for EDNRB:
    Hirschsprung's disease     Waardenburg's syndrome     ABCD syndrome     Hepatopulmonary syndrome
    Sensorineural hearing loss     Intestinal obstruction     Hypertension

    Find genes that share disorders with EDNRB           About GenesLikeMe

    Selected Novoseek inferred disease relationships for EDNRB gene (see all 68)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hirschsprung disease 89.9 108 15294878 (4), 12080062 (3), 10792313 (3), 14669347 (3) (see all 50)
    shah-waardenburg syndrome 89 9 8630502 (1), 11484199 (1), 19764031 (1), 16237557 (1) (see all 7)
    waardenburgs syndrome 85.6 4 11484199 (1), 9035423 (1), 9035203 (1)
    staphylococcal scalded skin syndrome 74.6 3 10447140 (1), 15815014 (1), 1703553 (1)
    hirschsprung disease 2 71.7 2 11484199 (1), 8001158 (1)
    colonic aganglionosis 70.1 4 8630503 (1), 9895385 (1), 10792313 (1)
    bullous impetigo 68.8 4 9431380 (2), 15815014 (2)
    acute poststreptococcal glomerulonephritis 62.6 3 11231350 (1), 16534181 (1), 19184118 (1)
    hypertension pulmonary 53.7 2 18567602 (1), 11000137 (1)
    lentigines 44.7 1 16145050 (1)

    GeneTests: EDNRB
    GeneReviews: EDNRB
    Genetic Association Database (GAD): EDNRB
    Human Genome Epidemiology (HuGE) Navigator: EDNRB (31 documents)

    Export disorders for EDNRB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for EDNRB gene, integrated from 10 sources (see all 587):
    (articles sorted by number of sources associating them with EDNRB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Significance of novel endothelin-B receptor gene polymorphisms in Hirschsprung's disease: predominance of a novel variant (561C/T) in patients with co-existing Down's syndrome. (PubMed id 12628594)1, 2, 4, 9 Zaahl M.G.... Moore S.W. (Mol. Cell. Probes 2003)
    2. Association between endothelin receptor B nonsynonymous variants and melanoma risk. (PubMed id 16145050)1, 4, 9 Soufir N....Grandchamp B. (J. Natl. Cancer Inst. 2005)
    3. Heterozygous endothelin receptor B (EDNRB) mutations in isolated Hirschsprung disease. (PubMed id 8852660)1, 2, 9 Amiel J....Lyonnet S. (Hum. Mol. Genet. 1996)
    4. Endothelin-B receptor mutations in patients with isolated Hirschsprung disease from a non-inbred population. (PubMed id 8852659)1, 2, 9 Auricchio A.... Ballabio A. (Hum. Mol. Genet. 1996)
    5. Mutation analysis of endothelin-B receptor gene in patients with Hirschsprung disease in Taiwan. (PubMed id 18162831)1, 4, 9 Lin Y.C....Chang M.H. (J. Pediatr. Gastroenterol. Nutr. 2008)
    6. Polymorphism in endothelin-related genes limits exercise-induced decreases in arterial stiffness in older subjects. (PubMed id 16567585)1, 4, 9 Iemitsu M....Matsuda M. (Hypertension 2006)
    7. New variations of the EDNRB gene and its association with sporadic Hirschsprung's disease in Korea. (PubMed id 17011274)1, 4, 9 Kim J.H....Seo J.M. (J. Pediatr. Surg. 2006)
    8. ETB receptor polymorphism is associated with airway obstruction. (PubMed id 17470272)1, 4, 9 TaillAc C....Crestani B. (BMC Pulm Med 2007)
    9. Association of single nucleotide polymorphisms in endothelin family genes with the progression of atherosclerosis in patients with essential hypertension. (PubMed id 17525706)1, 4, 9 Yasuda H....Kawano Y. (J Hum Hypertens 2007)
    10. Endothelin axis polymorphisms in patients with scleroderma. (PubMed id 16947775)1, 4, 9 Fonseca C....Abraham D. (Arthritis Rheum. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 1910 HGNC: 3180 AceView: EDNRB Ensembl:ENSG00000136160 euGenes: HUgn1910
    ECgene: EDNRB Kegg: 1910 H-InvDB: EDNRB

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for EDNRB Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=EDNRB[genesymbol]
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ednrb/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for EDNRB gene:
    Search GeneIP for patents involving EDNRB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of EDNRB
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for EDNRB (EDNRB/Endothelin R Type B)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     cDNA Clones for EDNRB (EDNRB/Endothelin R Type B)   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for EDNRB   OriGene RNAi products in human, mouse, rat for EDNRB  
     OriGene qPCR primer pairs and template standards for EDNRB   OriGene Protein Over-expression Lysate for EDNRB  
     OriGene MassSpec something-or-other for EDNRB   OriGene clones in human, mouse for EDNRB  
     OriGene qSTAR qPCR primer pairs in human, mouse for EDNRB   OriGene Purified Protein for EDNRB  
     OriGene ORF clones in mouse, rat for EDNRB   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for EDNRB   OriGene Custom Protein Services for EDNRB  

     
     
     Block miRNA regulation of human, mouse, rat EDNRB using miScript Target Protectors SeqTarget long-range PCR primers for resequencing EDNRB
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EDNRB Predesigned siRNA for gene silencing in human, mouse, rat EDNRB
     QuantiFast Probe-based Assays in human, mouse, rat EDNRB QuantiTect SYBR Green Assays in human, mouse, rat EDNRB
     PCR Arrays including human, mouse, rat EDNRB Search Chromatin IP Primers for EDNRB
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EDNRB  GeneGlobe Interaction Network for EDNRB
     Regulatory tfbs in EDNRB promoter
     GenScript Custom Purified and Recombinant Proteins Services for EDNRB GenScript cDNA clones with any tag delivered in your preferred vector for EDNRB
     GenScript EDNRB-overexpressing Cell Line for Assay CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for EDNRB
     Proteins for EDNRB
     Cell Lysates for EDNRB
     cDNA Clones for EDNRB
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Drugs for EDNRB
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     EDNRB antibodies
     EDNRB proteins
     EDNRB lysates
     Antibodies for EDNRB
     See all of Abcam's Antibodies, Kits and Proteins for EDNRB
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for EDNRB
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EDNRB
     SwitchGear 3'UTR luciferase reporter plasmids for EDNRB
     SwitchGear Promoter luciferase reporter plasmids for EDNRB
     ThermoFisher Antibody for EDNRB
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EDNRB
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EDNRB
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for EDNRB
     LSBio Antibodies in human, mouse, rat for EDNRB
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for EDNRB
      Search eBioscience for proteins for EDNRB
      Search eBioscience for elisas for EDNRB
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      EDNRB gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4