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EDNRA Gene

protein-coding   GIFtS: 72
GCID: GC04P148401

Endothelin Receptor Type A

  See EDNRA-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Endothelin Receptor Type A1 2     ETAR2
ET-A2 3     Endothelin Receptor Subtype A2
ETA2 3     Endothelin-1 Receptor2
ETA-R2 3     Endothelin-1-Specific Receptor2
ETRA2 3     G Protein-Coupled Receptor2
hET-AR2 3     Endothelin A Receptor3

External Ids:    HGNC: 31791   Entrez Gene: 19092   Ensembl: ENSG000001516177   OMIM: 1312435   UniProtKB: P251013   
ORGUL members:         

Export aliases for EDNRA gene to outside databases

Previous GC identifers: GC04P149211 GC04P148777 GC04P148979 GC04P148759 GC04P148621 GC04P144129


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for EDNRA Gene:
This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting
vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling
activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to
migraine headache resistance. Alternative splicing results in multiple transcript variants. (provided by RefSeq,
Oct 2009)

GeneCards Summary for EDNRA Gene:
EDNRA (endothelin receptor type A) is a protein-coding gene. Diseases associated with EDNRA include headache, and scarlet fever. GO annotations related to this gene include phosphatidylinositol phospholipase C activity and endothelin receptor activity. An important paralog of this gene is GRPR.

UniProtKB/Swiss-Prot: EDNRA_HUMAN, P25101
Function: Receptor for endothelin-1. Mediates its action by association with G proteins that activate a
phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2
>> ET3

summary for EDNRA Gene:
The endothelin A receptor (ETA receptor) is a member of the endothelin receptor group of G-protein-coupled
receptors that also includes ETB. They are located primarily in the vascular smooth muscle where they play a
role in vasoconstriction and cell proliferation. The human ETA receptor gene has been localized to
chromosome 4 (4q31.22).

Gene Wiki entry for EDNRA (Endothelin receptor type A) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the EDNRA gene promoter:
         c-Fos   AP-1   ATF-2   GATA-1   C/EBPalpha   CREB   deltaCREB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEDNRA promoter sequence
   Search Chromatin IP Primers for EDNRA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EDNRA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q31.22   Ensembl cytogenetic band:  4q31.22   HGNC cytogenetic band: 4q31.22

EDNRA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EDNRA gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P148401:  view genomic region     (about GC identifiers)

Start:
148,402,069 bp from pter      End:
148,466,106 bp from pter
Size:
64,038 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for EDNRA

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: EDNRA_HUMAN, P25101 (See protein sequence)
Recommended Name: Endothelin-1 receptor precursor  
Size: 427 amino acids; 48722 Da
Subunit: Interacts with HDAC7 and KAT5
Secondary accessions: B2R723 B4E2V6 B7Z9G6 D3DP03 E7ER36 O43441 Q16432 Q16433 Q8TBH2
Alternative splicing: 5 isoforms:  P25101-1   P25101-2   P25101-3   P25101-4   P25101-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for EDNRA: NX_P25101

Explore proteomics data for EDNRA at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn29, Asn62
  • Modification sites at PhosphoSitePlus

  • See EDNRA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001159527.1  NP_001243212.1  NP_001948.1  

    ENSEMBL proteins: 
     ENSP00000425354   ENSP00000315011   ENSP00000427259   ENSP00000425281   ENSP00000351359  
     ENSP00000341556  
    Reactome Protein details: P25101

    EDNRA Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for EDNRA
    OriGene Custom MassSpec
    OriGene Custom Protein Services for EDNRA
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    Novus Biologicals EDNRA Proteins
    Novus Biologicals EDNRA Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for EDNRA 

    EDNRA Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of EDNRA
    R&D Systems Antibodies for EDNRA (EDNRA/Endothelin R Type A)
    OriGene Antibodies for EDNRA
    OriGene Custom Antibody Services for EDNRA
    Novus Biologicals EDNRA Antibodies
    Abcam antibodies for EDNRA
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for EDNRA
    LSBio Antibodies in human, mouse, rat for EDNRA

    EDNRA Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript EDNRA-overexpressing Cell Line for Assay
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for EDNRA 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    EDNR: GPCR / Class A : Endothelin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: ETA receptor
    Endothelin receptors

    4 InterPro protein domains:
     IPR002175 ETA_rcpt
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000499 Endthln_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P25101

    ProtoNet protein and cluster: P25101

    2 Blocks protein domains:
    IPB000499 Endothelin receptor signature
    IPB002175 Endothelin-A receptor signature


    UniProtKB/Swiss-Prot: EDNRA_HUMAN, P25101
    Similarity: Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRA sub-subfamily


    Find genes that share domains with EDNRA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EDNRA_HUMAN, P25101
    Function: Receptor for endothelin-1. Mediates its action by association with G proteins that activate a
    phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2
    >> ET3

         Genatlas biochemistry entry for EDNRA:
    endothelin receptor A,with higher affinity to EDN1,G protein coupled receptor superfamily

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004435phosphatidylinositol phospholipase C activity TAS8702836
    GO:0004930G-protein coupled receptor activity ----
    GO:0004962endothelin receptor activity NAS8611157
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with EDNRA           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for EDNRA:
     Decreased Tat-dependent transc  Decreased melanin production  Decreased viability with carbo 

         Selected MGI mutant phenotypes (inferred from 8 alleles(MGI details for Ednra) (see all 16):
     cardiovascular system  craniofacial  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     muscle  nervous system  normal  renal/urinary system  respiratory system 

    Find genes that share phenotypes with EDNRA           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for EDNRA: Ednratm1Hku Ednratm1Ywa

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EDNRA
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for EDNRA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EDNRA
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EDNRA

    miRNA
    Products:
        
    miRTarBase miRNAs that target EDNRA:
    hsa-mir-203a (MIRT005749), hsa-mir-200c-3p (MIRT007344), hsa-mir-27b-3p (MIRT005753), hsa-mir-224-5p (MIRT005756)

    Block miRNA regulation of human, mouse, rat EDNRA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EDNRA (see all 24):
    hsa-miR-30c hsa-miR-4265 hsa-miR-3607-3p hsa-miR-522 hsa-miR-1271 hsa-miR-128 hsa-miR-30d hsa-miR-512-3p
    SwitchGear 3'UTR luciferase reporter plasmidEDNRA 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for EDNRA
    Predesigned siRNA for gene silencing in human, mouse, rat EDNRA

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for EDNRA

    Clone
    Products:
         
    OriGene clones in human, mouse for EDNRA (see all 11)
    OriGene ORF clones in mouse, rat for EDNRA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): EDNRA (NM_001957)
    Sino Biological Human cDNA Clone for EDNRA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EDNRA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EDNRA

    Cell Line
    Products:
         
    GenScript EDNRA-overexpressing Cell Line for Assay
    ESI BIO PureStem Progenitor for EDNRA: 
    PureStem Z11, Meso Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EDNRA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EDNRA_HUMAN, P25101: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton2
    cytosol2
    endoplasmic reticulum2
    extracellular2
    nucleus2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS1326535
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----
    GO:0030315T-tubule IEA--

    Find genes that share ontologies with EDNRA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for EDNRA About   (see all 14)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    Peptide ligand-binding receptors0.60
    2Neuropeptides signaling through G protein alpha i and G protein alpha q
    Peptide GPCRs0.46
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    5Development Endothelin 1 EDNRA signaling
    Development Endothelin 1 EDNRA signaling0.41
    Development Endothelin 1 EDNRA transactivation of EGFR0.41


    Find genes that share SuperPaths with EDNRA           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for EDNRA
        Endothelin-1 Signaling Pathway
    Signaling Involved in Cardiac Hypertrophy

    2 GeneGo (Thomson Reuters) Pathways for EDNRA
        Development Endothelin-1/EDNRA transactivation of EGFR
    Development Endothelin-1/EDNRA signaling

    Selected BioSystems Pathways for EDNRA (see all 7)
        GPCRs, Other
    Prostaglandin Synthesis and Regulation
    GPCRs, Class A Rhodopsin-like
    Endothelin
    Endothelins


    2 Reactome Pathways for EDNRA
        Peptide ligand-binding receptors
    G alpha (q) signalling events


    3 Kegg Pathways  (Kegg details for EDNRA):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction
    Vascular smooth muscle contraction

        Pathway & Disease-focused RT2 Profiler PCR Arrays including EDNRA: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Hypertension in human mouse rat
              Endothelial Cell Biology in human mouse rat
              Multiple Sclerosis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for EDNRA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for EDNRA (P251011, 3 ENSP000003150114) via UniProtKB, MINT, STRING, and/or I2D (see all 155)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EDN1P053051, 3, ENSP000003686834EBI-6624559,EBI-715181 I2D: score=1 STRING: ENSP00000368683
    ARRB1P494073, ENSP000003771414I2D: score=1 STRING: ENSP00000377141
    COPS5Q929053, ENSP000003505124I2D: score=1 STRING: ENSP00000350512
    GRK6P432503, ENSP000003772044I2D: score=1 STRING: ENSP00000377204
    HDAC7Q8WUI43, ENSP000000800594I2D: score=1 STRING: ENSP00000080059
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 48):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001569patterning of blood vessels IEA--
    GO:0001666response to hypoxia IEA--
    GO:0001701in utero embryonic development IEA--
    GO:0001821histamine secretion IEA--
    GO:0001934positive regulation of protein phosphorylation IEA--

    Find genes that share ontologies with EDNRA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for EDNRA
      Browse compounds at ApexBio 

    Compounds for EDNRA available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SulfisoxazoleEndothelin ETA antagonist[127-69-5]
    BMS 182874 hydrochloride Highly selective, orally active non-peptide ETA antagonist [153042-42-3]
    CI 1020 Highly selective, orally active ETA antagonist [162256-50-0]
    FR 139317 Highly potent, selective ETA antagonist [142375-60-8]
    BQ-123Selective ETA antagonist[136553-81-6]

    1 HMDB Compound for EDNRA    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    3 DrugBank Compounds for EDNRA    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    SitaxentanSitaxsentan (see all 2)210421-64-0targetantagonist11704565 11752352 17472992 11849873 11447307 11728166 10961375
    Bosentan-- 147536-97-8targetantagonist11704565 11752352 11849873 11447307 11728166 10961375
    2-HYDROXY-3,5-DIIODOBENZOIC ACID-- --target--11093786

    Selected IUPHAR Ligands for EDNRA (ETA receptor) (see all 20)    About this table
    LigandTypeActionAffinityPubmed IDs
    [125I]ET-1
    AgonistFull agonist9.1 - 10.58355464 7620699 7524189
    A127722
    AntagonistAntagonist10.58632312
    [125I]PD164333
    AntagonistAntagonist9.6 - 9.89489609
    [125I]sarafotoxin S6b
    AgonistFull agonist9.6 - 9.88851522
    PD-156707
    AntagonistAntagonist8.1 - 9.210066864 9023329
    [3H]S0139
    AntagonistAntagonist9.2--
    [125I]ET-2
    AgonistFull agonist8.9 - 9.18851522
    [125I]PD151242
    AntagonistAntagonist9 - 9.18012722
    SB234551
    AntagonistAntagonist8.7 - 99694916
    darusentan
    AntagonistAntagonist8.98667356

    Selected Novoseek inferred chemical compound relationships for EDNRA gene (see all 107)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bq123 93.9 92 7620699 (3), 8355464 (3), 1309703 (2), 7891013 (2) (see all 65)
    sitaxsentan 91.5 38 17163810 (2), 20404221 (2), 16932638 (1), 17314684 (1) (see all 27)
    sarafotoxin 91.3 30 8336519 (3), 8587426 (2), 7965709 (2), 8074203 (1) (see all 22)
    atrasentan 91.1 38 19960438 (2), 12576870 (2), 12586806 (2), 17886253 (2) (see all 27)
    bq788 88.1 28 17433294 (2), 12193073 (1), 16318777 (1), 18567602 (1) (see all 23)
    bq 3020 87 12 8355464 (3), 7891013 (2), 7679333 (2), 8121179 (1) (see all 5)
    bosentan 86.2 42 19850966 (3), 20404221 (2), 9265559 (2), 9731554 (2) (see all 29)
    fr139317 86.1 14 7891013 (2), 7965709 (2), 14996949 (2), 11078425 (1) (see all 11)
    ambrisentan 83.9 9 16741057 (2), 18506008 (1), 19601701 (1), 18238950 (1) (see all 7)
    darusentan 78.2 6 16439456 (1), 18616421 (1), 15915003 (1), 12472954 (1) (see all 5)



    Find genes that share compounds with EDNRA           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for EDNRA gene (3 alternative transcripts): 
    NM_001166055.1  NM_001256283.1  NM_001957.3  

    Unigene Cluster for EDNRA:

    Endothelin receptor type A
    Hs.183713  [show with all ESTs]
    Unigene Representative Sequence: NM_001957
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000511804 ENST00000324300(uc003iky.3 uc011cid.2 uc010ipf.1)
    ENST00000510697 ENST00000506066 ENST00000514245 ENST00000503721 ENST00000358556(uc010ipg.2)
    ENST00000339690(uc010ipe.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat EDNRA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EDNRA (see all 24):
    hsa-miR-30c hsa-miR-4265 hsa-miR-3607-3p hsa-miR-522 hsa-miR-1271 hsa-miR-128 hsa-miR-30d hsa-miR-512-3p
    SwitchGear 3'UTR luciferase reporter plasmidEDNRA 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for EDNRA
    Predesigned siRNA for gene silencing in human, mouse, rat EDNRA
    Clone
    Products:
         
    OriGene clones in human, mouse for EDNRA (see all 11)
    OriGene ORF clones in mouse, rat for EDNRA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): EDNRA (NM_001957)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EDNRA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EDNRA
    Primer
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    OriGene qPCR primer pairs and template standards for EDNRA
    OriGene qSTAR qPCR primer pairs in human, mouse for EDNRA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EDNRA
      QuantiTect SYBR Green Assays in human, mouse, rat EDNRA
      QuantiFast Probe-based Assays in human, mouse, rat EDNRA

    Additional mRNA sequence: 

    AF014826.1 AK304451.1 AK312812.1 AK315931.1 AY275462.1 BC022511.1 D90348.1 L06622.1 
    NR_045958.1 S45956.1 S57498.1 S63938.1 S67127.1 S81539.1 S81542.1 S81545.1 
    X61950.1 

    6 DOTS entries:

    DT.446880  DT.121274733  DT.95264375  DT.100682905  DT.91762983  DT.95264377 

    Selected AceView cDNA sequences (see all 142):

    BQ005145 AL692187 BQ575745 N57394 BQ018994 AU120519 BU687640 AF014826 
    BX109539 D57899 AW293402 BM548868 AY275462 CB045526 BM512298 BQ008268 
    AU117099 CD723797 AA043717 BQ006584 BU948045 AA450009 AI127771 AI953824 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for EDNRA (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b
    SP1:                                      -                                                   
    SP2:                                      -           -     -                                 
    SP3:                                      -     -     -     -                                 
    SP4:                    -     -     -                                                         
    SP5:                    -     -     -     -                                                   


    ECgene alternative splicing isoforms for EDNRA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EDNRA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    EDNRA Expression
    About this image


    EDNRA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 22) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 8 entries
             Bone Marrow
             HyStem+BMP4-induced MEL2 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 4 entries
             HyStem+TGFbeta3+GDF5-induced SM30 cells
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Testicular Interstitial Cells Testis Interstitium
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
    EDNRA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EDNRA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.183713

    UniProtKB/Swiss-Prot: EDNRA_HUMAN, P25101
    Tissue specificity: Isoform 1, isoform 3 and isoform 4 are expressed in a variety of tissues, with highest levels
    in the aorta and cerebellum, followed by lung, atrium and cerebral cortex, lower levels in the placenta, kidney,
    adrenal gland, duodenum, colon, ventricle and liver but no expression in umbilical vein endothelial cells. Within
    the placenta, isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in the villi and stem villi vessels

        Pathway & Disease-focused RT2 Profiler PCR Arrays including EDNRA: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Hypertension in human mouse rat
              Endothelial Cell Biology in human mouse rat
              Multiple Sclerosis in human mouse rat

    Primer
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for EDNRA gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ednra1 , 5 endothelin receptor type A1, 5 85.4(n)1
    92.27(a)1
      8 (36.63 cM)5
    136171  NM_010332.21  NP_034462.11 
     776630315 
    chicken
    (Gallus gallus)
    Aves EDNRA1 endothelin receptor type A 76.48(n)
    78.38(a)
      373908  NM_204119.1  NP_989450.1 
    lizard
    (Anolis carolinensis)
    Reptilia EDNRA6
    endothelin receptor type A
    70(a)
    1 ↔ 1
    5(134130990-134165227)
    African clawed frog
    (Xenopus laevis)
    Amphibia ednra-prov2 endothelin receptor type A 79.77(n)    BC044316.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ednraa1 endothelin receptor type Aa 68.08(n)
    73.45(a)
      114550  NM_001099445.1  NP_001092915.1 


    ENSEMBL Gene Tree for EDNRA (if available)
    TreeFam Gene Tree for EDNRA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for EDNRA gene
    GRPR2  GPR372  BRS32  EDNRB2  NMBR2  GPR37L12  
    3 SIMAP similar genes for EDNRA using alignment to 1 protein entry:     EDNRA_HUMAN:
    EDNRB    GRPR    NMBR

    Find genes that share paralogs with EDNRA           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for EDNRA (see all 1529)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0357584
    A breast cancer sample4--see VAR_0357582 I L mis40--------
    rs1387464571,2
    --144138557(+) ACACT-/CACAC 
     ACACACA
    CACAC
    4 -- int10--------
    rs1910077811,2
    --148186064(+) GTGTTA/GTGTAC 4 -- us2k10--------
    rs1808314471,2
    --148186150(+) TTGTTA/TCCATC 4 -- us2k10--------
    rs1463770061,2
    --148186198(+) TGCTGC/TTATGA 4 -- us2k10--------
    rs103058381,2
    C,F--148186249(+) TTATTT/CAGGTA 4 -- us2k17Minor allele frequency- C:0.25NS WA NA EA 522
    rs1384097571,2
    C--148186355(+) TTACAC/TTCAGA 4 -- us2k10--------
    rs103058391,2
    C,F--148186406(+) CAACAC/TTTGTT 4 -- us2k16Minor allele frequency- T:0.21NS WA NA EA 534
    rs1143060881,2
    F--148186450(+) GCTATC/TCTAAT 4 -- us2k11Minor allele frequency- T:0.03WA 118
    rs103058401,2
    C,F,H--148186493(+) CTACAC/TCACAG 4 -- us2k117Minor allele frequency- T:0.02NS EA NA CSA WA 1920

    HapMap Linkage Disequilibrium report for EDNRA (148402069 - 148466106 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for EDNRA:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2728508CNV Deletion23290073
    esv2274849CNV Deletion18987734
    nsv830110CNV Loss17160897
    nsv880241CNV Loss21882294
    nsv830109CNV Loss17160897

    Human Gene Mutation Database (HGMD): EDNRA
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing EDNRA
    DNA2.0 Custom Variant and Variant Library Synthesis for EDNRA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 131243   
    OMIM disorders: 157300  
    11 diseases for EDNRA:    
    About MalaCards
    headache    scarlet fever    migraine    staphylococcal scarlet fever
    impetigo    bullous impetigo    radiation proctitis    tonsillitis
    toxic shock syndrome    migraine without aura    colorectal cancer

    5 diseases from the University of Copenhagen DISEASES database for EDNRA:
    Hypertension     Impetigo     Heart disease     Scarlet fever
    Kidney failure

    Find genes that share disorders with EDNRA           About GenesLikeMe

    Selected Novoseek inferred disease relationships for EDNRA gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    staphylococcal scalded skin syndrome 79.5 7 10447140 (2), 11118740 (1), 10789506 (1), 9048539 (1) (see all 6)
    hypertension arterial 66 26 15486408 (2), 18506008 (1), 16932638 (1), 19601701 (1) (see all 21)
    staphylococcal scarlet fever 65.6 1 9431380 (1)
    hypertension pulmonary 64.1 14 7705179 (3), 9918974 (2), 11480254 (2), 11078412 (1) (see all 9)
    bullous impetigo 59.5 2 9431380 (2)
    ovarian carcinoma metastatic 57.7 2 17587812 (1), 16741062 (1)
    heart failure 50.4 24 10869543 (3), 15958361 (2), 10600660 (2), 15642529 (2) (see all 16)
    vasospasm 49.7 4 8784140 (1), 17933488 (1), 17437213 (1), 19623039 (1)
    peripheral edema 48.8 3 19304472 (1), 14571415 (1), 17886253 (1)
    ovarian carcinoma 48.1 58 16741063 (4), 15269139 (4), 12193113 (3), 9973223 (3) (see all 23)

    Genetic Association Database (GAD): EDNRA
    Human Genome Epidemiology (HuGE) Navigator: EDNRA (42 documents)

    Export disorders for EDNRA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EDNRA gene, integrated from 10 sources (see all 778):
    (articles sorted by number of sources associating them with EDNRA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and chromosomal localization of a human endothelin ETA receptor. (PubMed id 1659806)1, 2, 3 Cyr C.... Kris R. (Biochem. Biophys. Res. Commun. 1991)
    2. Alternative RNA splicing of the human endothelin-A receptor generates multiple transcripts. (PubMed id 8611157)1, 2, 9 Miyamoto Y....Nakao K. (Biochem. J. 1996)
    3. Cloning and characterization of cDNA encoding human A-type endothelin receptor. (PubMed id 1719979)1, 2, 9 Adachi M.... Miyamoto C. (Biochem. Biophys. Res. Commun. 1991)
    4. Polymorphism in endothelin-related genes limits exercise-induced decreases in arterial stiffness in older subjects. (PubMed id 16567585)1, 4, 9 Iemitsu M....Matsuda M. (Hypertension 2006)
    5. Endothelin axis polymorphisms in patients with scleroderma. (PubMed id 16947775)1, 4, 9 Fonseca C....Abraham D. (Arthritis Rheum. 2006)
    6. Association of EDNRA, but not WNK4 or FKBP1B, polymorphisms with essential hypertension. (PubMed id 14616768)1, 4, 9 Benjafield A.V....Morris B.J. (Clin. Genet. 2003)
    7. Molecular characterization and regulation of the human endothelin receptors. (PubMed id 8440682)1, 2, 9 Elshourbagy N.A.... Nambi P. (J. Biol. Chem. 1993)
    8. ETB receptor polymorphism is associated with airway obstruction. (PubMed id 17470272)1, 4, 9 TaillAc C....Crestani B. (BMC Pulm Med 2007)
    9. Association of single nucleotide polymorphisms in endothelin family genes with the progression of atherosclerosis in patients with essential hypertension. (PubMed id 17525706)1, 4, 9 Yasuda H....Kawano Y. (J Hum Hypertens 2007)
    10. Genetic polymorphisms in endothelin-receptor-subtype-a-gene as susceptibility factor for obstructive sleep apnea syndrome. (PubMed id 20083432)1, 4, 9 Buck D....Fietze I. (Sleep Med. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1909 HGNC: 3179 AceView: EDNRA Ensembl:ENSG00000151617 euGenes: HUgn1909
    ECgene: EDNRA Kegg: 1909 H-InvDB: EDNRA

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for EDNRA Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ednra/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for EDNRA gene:
    Search GeneIP for patents involving EDNRA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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