Aliases for EDNRA Gene
External Ids for EDNRA Gene
Previous GeneCards Identifiers for EDNRA Gene
This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
GeneCards Summary for EDNRA Gene
EDNRA (Endothelin Receptor Type A) is a Protein Coding gene. Diseases associated with EDNRA include migraine and scarlet fever. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include phosphatidylinositol phospholipase C activity and endothelin receptor activity. An important paralog of this gene is EDNRB.
UniProtKB/Swiss-Prot for EDNRA Gene
Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3
The endothelin A receptor (ETA receptor) is a member of the endothelin receptor group of G-protein-coupled receptors that also includes ETB. They are located primarily in the vascular smooth muscle where they play a role in vasoconstriction and cell proliferation. The human ETA receptor gene has been localized to chromosome 4 (4q31.22).