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EDNRA Gene

protein-coding GIFtS: 65

GC04P148621

endothelin receptor type A
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ET-A ^³
ETA ^², ³
ETA-R ^³
ETRA ^², ³
hET-AR ^³

Descriptions
Endothelin A receptor ^³
G protein-coupled receptor ^²
endothelin receptor type A ^²

External Ids
HGNC: 3179¹
Entrez Gene: 1909²
UniProtKB: P25101³
Ensembl: ENSG00000151617⁷

Search outside databases for aliases for EDNRA gene

Previous GC identifers: GC04P149211 GC04P148777 GC04P148979 GC04P148759

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: EDNRA_HUMAN, P25101

Function: Receptor for endothelin-1. Mediates its action by association with G proteins that

activate a phosphatidylinositol-calcium second messenger system. The rank order of binding

affinities for ET-A is: ET1 > ET2 >> ET3

Gene Wiki entry for EDNRA (Endothelin_receptor_type_A)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the EDNRA gene

Entrez Gene cytogenetic band: 4q31.23 Ensembl cytogenetic band: 4q31.23 HGNC chromosome: 4

EDNRA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04P148621: (about GC identifiers)

Start:	148,621,575 bp from pter
End:	148,685,555 bp from pter
Size:	63,981 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000004.10 NT_016354.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: EDNRA_HUMAN, P25101 (See protein sequence)

Recommended Name: Endothelin-1 receptor precursor

Size: 427 amino acids; 48722 Da

Subunit: Interacts with HDAC7 and HTATIP

Subcellular location: Cell membrane; Multi-pass membrane protein

Secondary accessions: O43441 Q16432 Q16433 Q8TBH2

Alternative splicing: 4 isoforms: P25101-1 P25101-2 P25101-3 P25101-4

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001948.1

ENSEMBL proteins:

ENSP00000377611 ENSP00000341556 ENSP00000315011 ENSP00000351359

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for EDNRA
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Endothelin A Receptor)
	Human Recombinant Proteins from Abnova (EDNRA)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0005887	integral to plasma membrane	TAS	1326535

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Antibodies for EDNRA:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of EDNRA
	Sigma-Aldrich Antibodies for EDNRA
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Endothelin A Receptor), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (EDNRA)
	Novus Biologicals Antibodies for EDNRA

Assays for EDNRA:

	Invitrogen Assays for EDNRA
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P25101

ProtoNet protein and cluster: P25101

2 Blocks protein families:

IPB000499 Endothelin receptor signature

IPB002175 Endothelin-A receptor signature

UniProtKB/Swiss-Prot: EDNRA_HUMAN, P25101

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (EDNRA)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (EDNRA)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001957

Applied Biosystems Silencer® siRNAs for EDNRA

Sigma-Aldrich siRNA and siRNA Panels for EDNRA

Sigma-Aldrich shRNA Panels and shRNA for EDNRA

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for EDNRA
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001957
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001957
untagged cDNA clone in CMV expression vector: NM_001957

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001957

UniProtKB/Swiss-Prot: EDNRA_HUMAN, P25101

Function: Receptor for endothelin-1. Mediates its action by association with G proteins that

activate a phosphatidylinositol-calcium second messenger system. The rank order of binding

affinities for ET-A is: ET1 > ET2 >> ET3

Genatlas biochemistry entry for EDNRA:

endothelin receptor A,with higher affinity to EDN1,G protein coupled receptor superfamily

15/16 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Ednra) (see all 16 ):

	craniofacial	digestive/alimentary	embryogenesis	endocrine/exocrine gland
hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	lethality-prenatal/perinatal
muscle	nervous system	normal	renal/urinary system	respiratory system

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001599	endothelin-A receptor activity	NAS	8611157
GO:0004435	phosphoinositide phospholipase C activity	TAS	8702836
GO:0004872	receptor activity	IEA	--
GO:0004930	G-protein coupled receptor activity	IEA	--
GO:0005515	protein binding	ISS	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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3 Sigma-Aldrich "Your Favorite Gene" Pathways for EDNRA (Your Favorite Gene powered by Ingenuity)

Hepatic Fibrosis / Hepatic Stellate Cell Activation
G-Protein Coupled Receptor Signaling
Endothelin-1 Signaling

GeneDecks EDNRA for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for EDNRA

5/49 Interacting proteins for EDNRA (ENSP00000315011³) via UniProtKB, MINT, and/or STRING (see all 49 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EDN1	ENSP00000368683³	STRING (score=.999)
EDN3	ENSP00000360067³	STRING (score=.999)
EDN2	ENSP00000361668³	STRING (score=.998)
GNA11	ENSP00000078429³	STRING (score=.989)
GNAQ	ENSP00000286548³	STRING (score=.976)

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5/11 Gene Ontology (GO) biological process terms (links to tree view) (see all 11 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006939	smooth muscle contraction	NAS	9284755
GO:0007165	signal transduction	TAS	1326535
GO:0007186	G-protein coupled receptor protein signaling pathway	NAS	8611157
GO:0007190	activation of adenylate cyclase activity	TAS	8702836
GO:0007202	activation of phospholipase C activity	TAS	8702836

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for EDNRA:

Antagonist

Compounds for EDNRA available from Tocris Bioscience

Compound	Action	CAS number
Sulfisoxazole	Endothelin ETA antagonist	[127-69-5]
BMS 182874 hydrochloride	Highly selective, orally active non-peptide ETA antagonist	[153042-42-3]
CI 1020	Highly selective, orally active ETA antagonist	[162256-50-0]
FR 139317	Highly potent, selective ETA antagonist	[142375-60-8]

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10/56 Novoseek chemical compound relationships for EDNRA gene (see all 56 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
sitaxsentan	90.79	30	17163810 (2), 16932638 (1), 17314684 (1), 15500395 (1) (see all 23)
sarafotoxin	90.69	29	8336519 (3), 8587426 (2), 7965709 (2), 8074203 (1) (see all 21)
bq 3020	87.82	13	8355464 (3), 7891013 (2), 7679333 (2), 8121179 (1) (see all 6)
fr139317	85.48	14	7891013 (2), 7965709 (2), 14996949 (2), 11078425 (1) (see all 11)
ambrisentan	83.49	7	16741057 (2), 18506008 (1), 18238950 (1), 19198697 (1) (see all 5)
lu135252	78.98	6	16439456 (1), 18616421 (1), 15915003 (1), 12472954 (1) (see all 5)
irl 1620	76.67	2	10705994 (1), 8650075 (1)
bq610	75.81	8	12147606 (2), 17433294 (2), 7796447 (1), 11034585 (1) (see all 5)
pd 142893	75.52	3	7965794 (1), 12147606 (1)
sitaxsentan sodium	72.82	4	15486408 (2), 15838366 (1)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (EDNRA)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (EDNRA)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001957

Sigma-Aldrich siRNA and siRNA Panels for EDNRA

Sigma-Aldrich shRNA Panels and shRNA for EDNRA

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001957

REFSEQ mRNAs for EDNRA gene:

NM_001957.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001957

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001957
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001957
                                 untagged cDNA clone in CMV expression vector: NM_001957

Additional cDNA sequence:

AF014826.1 AK304451.1 AK312812.1 AK315931.1 AY275462.1 BC022511.1 D90348.1 L06622.1

S45956.1 S57498.1 S63938.1 S67127.1 S81539.1 S81542.1 S81545.1 X61950.1

6 DOTS entries:

DT.446880 DT.121274733 DT.95264375 DT.100682905 DT.91762983 DT.95264377

24/142 AceView cDNA sequences (see all 142 ):

AU117099 BQ008268 BQ575745 CB045526 CD723797 BX109539 BM548868 N57394

D57899 BU687640 AW293402 BQ018994 BU948045 AY275462 BM512298 AL692187

AA043717 BQ005145 BQ006584 AF014826 AU120519 BP380731 AA452627 S81539

highest scoring ESTs for EDNRA:

AA011082 AA011083 AA043717 AA043718 AA058926 AA101845 AA101846 AA131759 AA131863 AA233928

Unigene Cluster for EDNRA:

Endothelin receptor type A

Hs.183713 [show with all ESTs]

Unigene Representative Sequence: NM_001957

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for EDNRA (see all 7 )

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	·	2c	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8	^	9a	·	9b
SP1:													-
SP2:													-				-		-
SP3:													-		-		-		-
SP4:							-		-		-
SP5:							-		-		-		-

About this scheme

ECgene alternative splicing isoforms for EDNRA

4 Ensembl transcripts including schematic representations:

ENST00000394047 ENST00000339690 ENST00000324300 ENST00000358556

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

EDNRA expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for EDNRA

¹ / ² / ³

7 probe-sets matching EDNRA gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1507_s_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	D11151	0.20	1.00	0.72	1
216235_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	S81545	0.80	0.88	0.84	1
204463_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AU118882	0.80	1.00	0.91	1
204464_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001957	0.60	1.00	0.82	1
216235_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
204463_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
204464_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks EDNRA for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.183713
Expression variation in blood from EXPOLDB for EDNRA
UniProtKB/Swiss-Prot: EDNRA_HUMAN, P25101
Tissue specificity: Isoform 1, isoform 3 and isoform 4 are expressed in a variety of tissues, with
highest levels in the aorta and cerebellum, followed by lung, atrium and cerebral cortex, lower
levels in the placenta, kidney, adrenal gland, duodenum, colon, ventricle and liver but no
expression in umbilical vein endothelial cells. Within the placenta, isoform 1, isoform 2, isoform
3 and isoform 4 are expressed in the villi and stem villi vessels

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for EDNRA gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	EDNRA¹	--	endothelin receptor type A	93.04(n) 95.07(a)	450187 XM_848372.1 XP_853465.1
chimpanzee (Pan troglodytes)	EDNRA¹	--	endothelin receptor type A	99.61(n) 100(a)	461530 XM_001149597.1 XP_001149597.1
cow (Bos taurus)	EDNRA¹	--	endothelin receptor type A	91.26(n) 94.61(a)	281749 NM_174308.1 NP_776733.1
rat (Rattus norvegicus)	Ednra¹	--	endothelin receptor type A	85.92(n) 92.72(a)	24326 NM_012550.1 NP_036682.1
mouse (Mus musculus)	Ednra^{1, 5}	8⁵	endothelin receptor type A^{1, 5}	85.4(n)¹ 92.27(a)¹	13617¹ NM_010332.2¹ NP_034462.1¹ AA388119⁵ AF039892⁵ (see all 14)

About this table Species with no ortholog for EDNRA

ENSEMBL Gene Tree for EDNRA

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for EDNRA gene

EDNRB²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/510 NCBI SNPs in EDNRA are shown (see all 510 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 192)

AB	SNP ID	Valid	Chr 4 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs5342^1,2	A,C,F,H	148684221(+)	`GATTCA/GGAAAT`	1	--	ut3¹		15	MN EA NS NA EU WA	2726
	rs5335^1,2	A,C,F,H	148683290(+)	`TGTGAC/GTCCGG`	1	--	ut3¹ ese³		18	MN EA NS NA EU WA	3038
	rs5341^1,2	C,F,H,O	148684049(+)	`ATAGTT/CCTTTT`	1	--	ut3¹		20	MN NS EU EA WA NA	1968
	rs1801708^1,2	A,C,F,H	148621819(+)	`CAGGAA/GGTTTT`	1	--	ut5¹ ese³		16	NS MN EU EA WA NA	1608
	rs5343^1,2	A,C,F,H	148684442(+)	`CACTTC/TTTGGG`	1	--	ut3¹ ese³		14	MN NS EU EA WA NA	1380
	rs6842241^1,2	A,C,F,H	148620269(+)	`CCCTCC/ATAGAG`	1	--	ng5¹ trp³		11	EU EA WA NS	1066
	rs6841581^1,2	C,F,H	148620640(+)	`cgcacG/Atggag`	1	--	ng5¹ tfbs³		15	EU EA WA NS	1498
	rs10305840^1,2	C,F,H	148619950(+)	`CTACAC/TCACAG`	1	--	ng5¹		9	NS EU EA WA	1006
	rs5344^1,2	C,F,H	148684749(+)	`AGTGCA/GTAGTC`	1	--	ut3¹ ese³		13	MN NS EU EA WA	1340
	rs1800786^1,2	C,F,H	148685607(+)	`TTACAT/CAATGC`	1	--	ng3¹		11	NS EU EA WA	1078

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HapMap Linkage Disequilibrium images for EDNRA (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 131243 disorders: 157300

10/96 Novoseek disease relationships for EDNRA gene (see all 96 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
staphylococcal scalded skin syndrome	80.35	7	10447140 (2), 11118740 (1), 10789506 (1), 9048539 (1) (see all 6)
staphylococcal scarlet fever	67.23	1	9431380 (1)
hypertension arterial	64.26	23	15486408 (2), 18506008 (1), 16932638 (1), 12975426 (1) (see all 18)
hypertension pulmonary	62.28	14	7705179 (3), 9918974 (2), 11480254 (2), 11078412 (1) (see all 9)
bullous impetigo	61.10	2	9431380 (2)
ovarian carcinoma metastatic	58.72	2	17587812 (1), 16741062 (1)
heart failure	51.15	24	10869543 (3), 15958361 (2), 10600660 (2), 15642529 (2) (see all 16)
vasospasm	49.93	3	8784140 (1), 17933488 (1), 17437213 (1)
ovarian carcinoma	49.73	58	16741063 (4), 15269139 (4), 12193113 (3), 9973223 (3) (see all 23)
cerebral vasospasm	48.04	1	16121967 (1)

About this table

Human Gene Mutation Database: EDNRA
Genetic Association Database: EDNRA
Human Genome Epidemiology Navigator: EDNRA (26 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/602 PubMed articles for EDNRA gene (see all 602 ):

Cloning and chromosomal localization of a human endothelin ETA receptor. (PubMed id 1659806)^{2, 3, 4} Cyr C.... Kris R. (1991)
Alternative RNA splicing of the human endothelin-A receptor generates multiple transcripts. (PubMed id 8611157)^{1, 3, 4} Miyamoto Y....Nakao K. (1996)
Cloning and characterization of cDNA encoding human A-type endothelin receptor. (PubMed id 1719979)^{1, 3, 4} Adachi M.... Miyamoto C. (1991)
Association of EDNRA, but not WNK4 or FKBP1B, polymorphisms with essential hypertension. (PubMed id 14616768)^{1, 3, 6} Benjafield A.V....Morris B.J. (2003)
Molecular characterization and regulation of the human endothelin receptors. (PubMed id 8440682)^{1, 3, 4} Elshourbagy N.A.... Nambi P. (1993)
Endothelin-1 and ETA receptor expression in vascular smooth muscle cells from human placenta: a new ETA receptor messenger ribonucleic acid is generated by alternative splicing of exon 3. (PubMed id 9284755)^{1, 3, 4} Bourgeois C.... Ferre F. (1997)
Association between glaucoma and gene polymorphism of endothelin type A receptor. (PubMed id 15988412)^{1, 3, 6} Ishikawa K....Mashima Y. (2005)
A polymorphism in the endothelin-A receptor gene is linked to baroreflex sensitivity. (PubMed id 16208144)^{3, 6} Ormezzano O....Baguet J.P. (2005)
Polymorphisms in genes of the endothelin system and cerebral small-vessel disease. (PubMed id 16002759)^{3, 6} Gormley K....Markus H.S. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 1909	HGNC: 3179	AceView: EDNRA	Ensembl:ENSG00000151617	euGenes: HUgn1909
ECgene: EDNRA	H-InvDB: EDNRA

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
NIEHS-SNPs	http://egp.gs.washington.edu/data/ednra/

Licensable Technologies for EDNRA
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for EDNRA:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for EDNRA-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for EDNRA		Antibodies for EDNRA
	Explore super-pooled esiRNAs		Proteins for EDNRA
	Lentivirus-delivered shRNAs for EDNRA		Small molecules for EDNRA
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (EDNRA)
	Antibodies (EDNRA)
	Chimera RNAi (EDNRA)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (Endothelin A Receptor)
	Antibodies (Endothelin A Receptor)

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Tocris compounds for EDNRA

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for EDNRA

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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EDNRA Gene at Home site.
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EDNRA Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for EDNRA

Summaries
for EDNRA

Genomic Location
for EDNRA

Proteins
for EDNRA

Protein Domains/
Families
for EDNRA

Gene Function
for EDNRA

Pathways & Interactions
for EDNRA

Drugs & Compounds
for EDNRA

Transcripts
for EDNRA

Expression
for EDNRA

Orthologs
for EDNRA

Paralogs
for EDNRA

SNPs/Variants
for EDNRA

Disorders & Mutations
for EDNRA

Medical News
for EDNRA

Publications
for EDNRA

Search for EDNRA

Genome Databases showing EDNRA

Other Databases showing EDNRA

Specialized Databases showing EDNRA

Licensable Technologies
for EDNRA

Services
for EDNRA

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

EDNRA Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor EDNRA

Summariesfor EDNRA

Genomic Locationfor EDNRA

Proteinsfor EDNRA

Protein Domains/Familiesfor EDNRA

Gene Functionfor EDNRA

Pathways & Interactionsfor EDNRA

Drugs & Compoundsfor EDNRA

Transcriptsfor EDNRA

Expression for EDNRA

Orthologsfor EDNRA

Paralogsfor EDNRA

SNPs/Variantsfor EDNRA

Disorders & Mutationsfor EDNRA

Medical Newsfor EDNRA

Publicationsfor EDNRA

Search for EDNRA

Genome Databases showing EDNRA

Other Databases showing EDNRA

Specialized Databases showing EDNRA

Licensable Technologiesfor EDNRA

Servicesfor EDNRA

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for EDNRA

Summaries
for EDNRA

Genomic Location
for EDNRA

Proteins
for EDNRA

Protein Domains/
Families
for EDNRA

Gene Function
for EDNRA

Pathways & Interactions
for EDNRA

Drugs & Compounds
for EDNRA

Transcripts
for EDNRA

Expression
for EDNRA

Orthologs
for EDNRA

Paralogs
for EDNRA

SNPs/Variants
for EDNRA

Disorders & Mutations
for EDNRA

Medical News
for EDNRA

Publications
for EDNRA

Licensable Technologies
for EDNRA

Services
for EDNRA