V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

EDN3 Gene

protein-coding GIFtS: 63

GC20P057308

endothelin 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ET-3 ^³
ET3 ^¹, ²
MGC15067 ^²
MGC61498 ^²
OTTHUMP00000031420 ^²
PPET3 ^³
Preproendothelin-3 ^³

Descriptions
endothelin 3 ^²
truncated endothelin 3 ^²

External Ids
HGNC: 3178¹
Entrez Gene: 1908²
UniProtKB: P14138³
Ensembl: ENSG00000124205⁷

Search outside databases for aliases for EDN3 gene

Previous GC identifers: GC20P057603 GC20P058513 GC20P058560

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for EDN3:

The protein encoded by this gene is a member of the endothelin family. Endothelins are

endothelium-derived vasoactive peptides involved in a variety of biological functions. The active

form of this protein is a 21 amino acid peptide processed from the precursor protein. The active

peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin

with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes

and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung

disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural

crest-derived cells. Four alternatively spliced transcript variants encoding three distinct

isoforms have been observed. [provided by RefSeq]

UniProtKB/Swiss-Prot: EDN3_HUMAN, P14138

Function: Endothelins are endothelium-derived vasoconstrictor peptides

Gene Wiki entry for EDN3 (Endothelin_3)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the EDN3 gene

Entrez Gene cytogenetic band: 20q13.2-q13.3 Ensembl cytogenetic band: 20q13.32 HGNC cytogenetic band: 20q13.2-q13.3

EDN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20P057308: (about GC identifiers)

Start:	57,308,877 bp from pter
End:	57,334,442 bp from pter
Size:	25,566 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000020.9 NT_011362.9

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: EDN3_HUMAN, P14138 (See protein sequence)

Recommended Name: Endothelin-3 precursor

Size: 238 amino acids; 25454 Da

Subcellular location: Secreted

Secondary accessions: Q03229

Alternative splicing: 2 isoforms: P14138-1 P14138-2

REFSEQ proteins (4 alternative transcripts):

NP_000105.1 NP_996915.1 NP_996916.1 NP_996917.1

ENSEMBL proteins:

ENSP00000337128 ENSP00000379015 ENSP00000311854 ENSP00000360067 ENSP00000360064

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for EDN3
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (pan Endothelin, Endothelin 3)
	Human Recombinant Proteins from Abnova (EDN3)

OriGene Purified Recombinant Human Protein: EDN3

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005615	extracellular space	IDA	15691296
GO:0005625	soluble fraction	TAS	8298278

About this table

Antibodies for EDN3:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for EDN3
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (pan Endothelin, Endothelin 3), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (EDN3)
	Novus Biologicals Antibodies for EDN3

Assays for EDN3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P14138

ProtoNet protein and cluster: P14138

2 Blocks protein families:

IPB003641 Endothelin

IPB003642 Sarafotoxin/bibrotoxin

UniProtKB/Swiss-Prot: EDN3_HUMAN, P14138

Similarity: Belongs to the endothelin/sarafotoxin family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (EDN3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (EDN3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_000114

Applied Biosystems Silencer® siRNAs for EDN3

Sigma-Aldrich siRNA and siRNA Panels for EDN3

Sigma-Aldrich shRNA for EDN3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for EDN3
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_000114
Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_000114
untagged cDNA clones in CMV expression vector (see all 4): NM_000114

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000114

UniProtKB/Swiss-Prot: EDN3_HUMAN, P14138

Function: Endothelins are endothelium-derived vasoconstrictor peptides

Genatlas biochemistry entry for EDN3:

endothelin 3 (vaso-constrictor/pressor peptide),murine lethal spotting homologous

6 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Edn3):

digestive/alimentary	lethality-postnatal	life span-post-weaning/aging	nervous system	pigmentation
skin/coat/nails

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005179	hormone activity	IDA	2649896 10770212
GO:0031708	endothelin B receptor binding	IPI	1713452

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for EDN3

5/28 Interacting proteins for EDN3 (ENSP00000360067³) via UniProtKB, MINT, and/or STRING (see all 28 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EDNRA	ENSP00000315011³	STRING (score=.999)
EDNRB	ENSP00000366416³	STRING (score=.999)
MITF	ENSP00000295600³	STRING (score=.976)
KEL	ENSP00000347409³	STRING (score=.969)
ECE1	ENSP00000364028³	STRING (score=.963)

About this table

5/16 Gene Ontology (GO) biological process terms (links to tree view) (see all 16 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002690	positive regulation of leukocyte chemotaxis	IDA	9696419
GO:0003100	regulation of systemic arterial blood pressure by endothelin	IDA	2649896
GO:0007166	cell surface receptor linked signal transduction	IDA	1713452
GO:0007267	cell-cell signaling	TAS	8298278
GO:0007275	multicellular organismal development	TAS	8630502

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for EDN3 available from Tocris Bioscience

Compound	Action	CAS number
BMS 182874 hydrochloride	Highly selective, orally active non-peptide ETA antagonist	[153042-42-3]
BQ 788 sodium salt	Selective ETB antagonist	[156161-89-6]
IRL-1620	Highly selective ETB agonist	[142569-99-1]
FR 139317	Highly potent, selective ETA antagonist	[142375-60-8]
BQ-123	Selective ETA antagonist	[136553-81-6]

About this table

10/48 Novoseek chemical compound relationships for EDN3 gene (see all 48 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
sarafotoxin	95.32	127	2282471 (3), 7965709 (3), 9124371 (3), 1848560 (2) (see all 86)
fr139317	88.48	5	9595416 (1), 9440503 (1), 9831924 (1), 7965709 (1)
bq 3020	83.52	2	8473300 (1), 8538918 (1)
irl 1620	83.42	7	8473300 (1), 7616437 (1), 9440503 (1), 8568666 (1) (see all 7)
pd 142893	79.12	4	7616437 (1), 8786643 (1), 9272381 (1), 8216314 (1)
bq 485	73.08	1	9870082 (1)
bq610	63.24	1	10445306 (1)
calcium	40.35	91	7881751 (6), 8587346 (5), 8880069 (5), 7763261 (4) (see all 38)
phosphoinositide	37.79	10	2159294 (1), 1681032 (1), 8226866 (1), 7509982 (1) (see all 7)
inositol triphosphate	34.17	1	8447814 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (EDN3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (EDN3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_000114

Sigma-Aldrich siRNA and siRNA Panels for EDN3

Sigma-Aldrich shRNA for EDN3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000114 NM_207032 NM_207033 NM_207034

REFSEQ mRNAs for EDN3 gene (4 alternative transcripts):

NM_000114.2 NM_207032.1 NM_207033.1 NM_207034.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000114 NM_207032 NM_207033 NM_207034

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_000114
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_000114
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_000114

Additional cDNA sequence:

BC008876.2 BC053866.1 BT007085.1 DQ096281.1 J05081.1 S50864.1 S50866.1 X52001.1

5 DOTS entries:

DT.114182 DT.100748839 DT.40271247 DT.97802238 DT.97766026

24/64 AceView cDNA sequences (see all 64 ):

BC008876 BT007085 CK905827 NM_207034 CD723234 BM505488 X52001 BM672979

BM663176 NM_207033 S50866 BX099047 W96122 BC053866 NM_000114 NM_207032

W96123 AA553611 BM685342 AI590652 CK905826 AL546954 AA779341 T67005

highest scoring ESTs for EDN3:

J05081 X52001 AA551364 AA553611 AA700198 AA758487 AA779341 AI590652 AI676247 AI952334

Unigene Cluster for EDN3:

Endothelin 3

Hs.1408 [show with all ESTs]

Unigene Representative Sequence: BC053866

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for EDN3

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4a	·	4b	^	5a	·	5b	·	5c	·	5d
SP1:															-
SP2:
SP3:													-		-
SP4:													-		-

About this scheme

ECgene alternative splicing isoforms for EDN3

5 Ensembl transcripts including schematic representations:

ENST00000337938 ENST00000395654 ENST00000311585 ENST00000371028 ENST00000371025

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

EDN3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for EDN3

¹ / ² / ³

6 probe-sets matching EDN3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
160040_at²^{, 3}	U95-A	1	1.00	1.00	0.99	0.85	X52001	1.00	1.00	1.00	1
37865_at²^{, 3}	U95-A	1	1.00	1.00	0.98	1.16	J05081	1.00	1.00	1.00	1
217154_s_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
208399_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000114	0.60	1.00	0.82	1
217154_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208399_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AGGAAATGAA

SOURCE GeneReport for Unigene cluster: Hs.1408
Expression variation in blood from EXPOLDB for EDN3
UniProtKB/Swiss-Prot: EDN3_HUMAN, P14138
Tissue specificity: Expressed in trophoblasts and placental stem villi vessels, but not in cultured
placental smooth muscle cells

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for EDN3 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	EDN3¹	--	endothelin 3	79.75(n) 73.66(a)	403406 NM_001002942.1 NP_001002942.1
chimpanzee (Pan troglodytes)	EDN3¹	--	endothelin 3	99.39(n) 99.09(a)	469989 XM_525373.2 XP_525373.2
cow (Bos taurus)	EDN3¹	--	endothelin 3	73.06(n) 61.11(a)	513753 XM_591496.3 XP_591496.2
rat (Rattus norvegicus)	Edn3¹	--	endothelin 3	74.39(n) 62.15(a)	366270 XM_001072605.1 XP_001072605.1
mouse (Mus musculus)	Edn3^{1, 5}	2 (104.00 cM)⁵	endothelin 3^{1, 5}	76.1(n)¹ 66.83(a)¹	13616¹ NM_007903.3¹ NP_031929.1¹ AA122697⁵ AI854136⁵ (see all 15)

About this table Species with no ortholog for EDN3

ENSEMBL Gene Tree for EDN3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for EDN3 gene

EDN2² EDN1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/306 NCBI SNPs in EDN3 are shown (see all 306 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 193)

AB	SNP ID	Valid	Chr 20 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs155002^1,2	A,C,F,H	57308558(+)	`TACACC/TGAGTT`	4	--	ng5¹ tfbs³		5		EU EA WA NS	530
	rs11570248^1,2	C,F,H	57307333(+)	`CGGTTT/GATCAG`	4	--	ng5¹		11		NS EU EA WA	1238
	rs11570356^1,2	C,F,H	57333509(+)	`AAGGAA/GGAAGA`	4	--	ut3¹ trp³		11		NS EU EA WA	1250
	rs11570358^1,2	C,F,H	57333921(+)	`GCCTGC/TGCAGG`	4	--	ut3¹ ese³		9		NS EU WA	1080
	rs3026572^1,2	C,F,H	57333866(-)	`GGCTCG/AGTGGG`	4	--	ut3¹ ese³		11		NS EU EA WA	1238
	rs3026575^1,2	C,F	57333080(-)	`TCATTC/TGGATT`	4	--	ut3¹ int¹		1		NS	170
	rs3026570^1,2	C,F	57334484(-)	`GATGCG/ACAACC`	4	--	ng3¹		7		NS	816
	rs11570353^1,2	F,H	57333074(+)	`TGCCCA/GAATCC`	4	--	ut3¹ int¹		5		NS EU EA WA	568
	rs260742^1,2	A,C	57306974(-)	`AAAGTC/TCTTGG`	4	--	ng5¹		0	--	--	--	--
	rs3026573^1,2	C,F	57333773(-)	`ACAAAG/CAATTT`	4	--	ut3¹		7		NS	838

About this table

HapMap Linkage Disequilibrium images for EDN3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 131242 disorders: 277580 209880 142623

UniProtKB/Swiss-Prot: EDN3_HUMAN, P14138

Defects in EDN3 are the cause of Hirschsprung disease type 1 (HSCR1) [MIM:142623]; also

known as aganglionic megacolon. This genetic disorder of neural crest development is characterized

by the absence of intramural ganglion cells in the hindgut; often resulting in intestinal

obstruction

Defects in EDN3 are a cause of congenital central hypoventilation syndrome (CCHS)

[MIM:209880]; also known as congenital failure of autonomic control or Ondine curse. CCHS is a

rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or

lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of

respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia

and hypoxemia

Defects in EDN3 are a cause of Waardenburg syndrome type IV (WS4) [MIM:277580]; also known

as Waardenburg-Shah syndrome. WS4 is characterized by the association of Waardenburg features

(depigmentation and deafness) and the absence of enteric ganglia in the distal part of the

intestine (Hirschsprung disease)

10/50 Novoseek disease relationships for EDN3 gene (see all 50 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
shah-waardenburg syndrome	87.85	7	8630503 (1), 11303518 (1), 9359047 (1), 9279758 (1) (see all 6)
hirschsprung disease	85.35	48	10792313 (4), 14669347 (3), 9094028 (1), 19183406 (1) (see all 23)
waardenburgs syndrome	81.81	4	8630503 (1), 9359047 (1), 9035203 (1)
colonic aganglionosis	59.73	5	8630503 (1), 9895385 (1), 10792313 (1)
central hypoventilation syndrome, congenital	53.48	1	8696331 (1)
subarachnoid hemorrhage	34.94	5	1983878 (2), 9385564 (1), 1410800 (1), 7815135 (1)
cerebral vasospasm	31.97	2	1983878 (2)
vasospasm	22.80	1	8301307 (1)
hypertension pulmonary	20.96	1	8431058 (1)
cirrhosis	20.63	30	8719927 (6), 7875671 (4), 7499784 (4), 8750167 (4) (see all 11)

About this table

GeneTests: EDN3

Hirschsprung Disease

Human Gene Mutation Database: EDN3
Human Genome Epidemiology Navigator: EDN3 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/477 PubMed articles for EDN3 gene (see all 477 ):

A homozygous mutation in the endothelin-3 gene associated with a combined Waardenburg type 2 and Hirschsprung phenotype (Shah- Waardenburg syndrome). (PubMed id 8630503)^{1, 3, 4} Hofstra R.M.W.... Buys C.H.C.M. (1996)
SOX10 mutations in chronic intestinal pseudo-obstruction suggest a complex physiopathological mechanism. (PubMed id 12189494)^{1, 3, 4} Pingault V.... Goossens M. (2002)
Endothelin-3 gene mutations in isolated and syndromic Hirschsprung disease. (PubMed id 9359047)^{1, 3, 4} Bidaud C....Lyonnet S. (1997)
Mutations in Hirschsprung disease: when does a mutation contribute to the phenotype. (PubMed id 9359036)^{1, 3, 4} Hofstra R.M.W.... Buys C.H.C.M. (1997)
Endothelin-3 frameshift mutation in congenital central hypoventilation syndrome. (PubMed id 8696331)^{1, 3, 4} Bolk S.... Chakravarti A. (1996)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{3, 4} Deloukas P....Rogers J. (2001)
Endothelin-1 and ETA receptor expression in vascular smooth muscle cells from human placenta: a new ETA receptor messenger ribonucleic acid is generated by alternative splicing of exon 3. (PubMed id 9284755)^{3, 4} Bourgeois C.... Ferre F. (1997)
Solution structure of endothelin-3 determined using NMR spectroscopy. (PubMed id 1610811)^{3, 4} Mills R.G.... King G.F. (1992)
One of the endothelin gene family, endothelin 3 gene, is expressed in the placenta. (PubMed id 2178974)^{3, 4} Onda H.... Fujino M. (1990)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 1908	HGNC: 3178	AceView: EDN3	Ensembl:ENSG00000124205	euGenes: HUgn1908
ECgene: EDN3	H-InvDB: EDN3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
GeneReviews	http://www.genetests.org/query?gene=EDN3
NIEHS-SNPs	http://egp.gs.washington.edu/data/edn3/

Licensable Technologies for EDN3
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for EDN3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for EDN3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for EDN3		Antibodies for EDN3
	Explore super-pooled esiRNAs		Proteins for EDN3
	Lentivirus-delivered shRNAs for EDN3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (EDN3)
	Antibodies (EDN3)
	Chimera RNAi (EDN3)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (pan Endothelin, Endothelin 3)
	Antibodies (pan Endothelin, Endothelin 3)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Tocris compounds for EDN3

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for EDN3

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
EDN3 Gene at Home site.
Version 2.41.1
server5.xennexinc.com

EDN3 Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for EDN3

Summaries
for EDN3

Genomic Location
for EDN3

Proteins
for EDN3

Protein Domains/
Families
for EDN3

Gene Function
for EDN3

Pathways & Interactions
for EDN3

Drugs & Compounds
for EDN3

Transcripts
for EDN3

Expression
for EDN3

Orthologs
for EDN3

Paralogs
for EDN3

SNPs/Variants
for EDN3

Disorders & Mutations
for EDN3

Medical News
for EDN3

Publications
for EDN3

Search for EDN3

Genome Databases showing EDN3

Other Databases showing EDN3

Specialized Databases showing EDN3

Licensable Technologies
for EDN3

Services
for EDN3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

EDN3 Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor EDN3

Summariesfor EDN3

Genomic Locationfor EDN3

Proteinsfor EDN3

Protein Domains/Familiesfor EDN3

Gene Functionfor EDN3

Pathways & Interactionsfor EDN3

Drugs & Compoundsfor EDN3

Transcriptsfor EDN3

Expression for EDN3

Orthologsfor EDN3

Paralogsfor EDN3

SNPs/Variantsfor EDN3

Disorders & Mutationsfor EDN3

Medical Newsfor EDN3

Publicationsfor EDN3

Search for EDN3

Genome Databases showing EDN3

Other Databases showing EDN3

Specialized Databases showing EDN3

Licensable Technologiesfor EDN3

Servicesfor EDN3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for EDN3

Summaries
for EDN3

Genomic Location
for EDN3

Proteins
for EDN3

Protein Domains/
Families
for EDN3

Gene Function
for EDN3

Pathways & Interactions
for EDN3

Drugs & Compounds
for EDN3

Transcripts
for EDN3

Expression
for EDN3

Orthologs
for EDN3

Paralogs
for EDN3

SNPs/Variants
for EDN3

Disorders & Mutations
for EDN3

Medical News
for EDN3

Publications
for EDN3

Licensable Technologies
for EDN3

Services
for EDN3