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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

EDN2 Gene

protein-coding GIFtS: 61
GCID: GC01M041944

endothelin 2

Explore 31 diseases affiliated with
EDN2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Endothelin 2¹ ²		Endothelin-2¹
ET2¹ ²		Preproendothelin 2²
ET-2² ³		Preproendothelin-2³
PPET2² ³		Preproendothelin-2³

External Ids:	HGNC: 3177¹	Entrez Gene: 1907²	Ensembl: ENSG00000127129⁷	OMIM: 131241⁵	UniProtKB: P20800³

Export aliases for EDN2 gene to outside databases

Previous GC identifers: GC01M041972 GC01M040948 GC01M041407 GC01M041357 GC01M041613 GC01M041717 GC01M040063

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for EDN2:

This gene encodes a member of the endothelin protein family of secretory vasoconstrictive peptides. The preproprotein

is processed to a short mature form which functions as a ligand for the endothelin receptors that initiate

intracellular signaling events. This gene product is involved in a wide range of biological processes, such as

hypertension and ovulation. (provided by RefSeq, Oct 2008)

UniProtKB/Swiss-Prot: EDN2_HUMAN, P20800

Function: Endothelins are endothelium-derived vasoconstrictor peptides

summary for EDN2:

The endothelin family consists of highly potent vasoconstrictive peptides. Three endogenous isoforms are

known to exist, ET-1, ET-2 and ET-3, and two distinct endothelin receptors have so far been cloned in

mammals, classified as ETA and ETB receptors. Endothelin receptors are widely expressed in all tissues,

which is consistent with their physiological role as vasoactive peptides. They are also localized to

non-vascular structures including epithelial cells, glia and neurons. The principle physiological role of

endothelin receptors is the maintenance of vascular tone. They also have co-mitogenic activity, potentiating

the effects of other growth factors such as PDGF.

Gene Wiki entry for EDN2 (Endothelin 2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_032977.9

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the EDN2 gene promoter:
E2F-4 E2F-3a E2F-5 Lmo2 Nkx2-5 E2F-2 NF-AT E2F-1 E2F STAT3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: EDN2 promoter sequence

Search SABiosciences Chromatin IP Primers for EDN2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EDN2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34 Ensembl cytogenetic band: 1p34.2 HGNC cytogenetic band: 1p34

EDN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EDN2 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M041944: view genomic region (about GC identifiers)

Start:	41,944,446 bp from pter	End:	41,950,344 bp from pter
Size:	5,899 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: EDN2_HUMAN, P20800 (See protein sequence)

Recommended Name: Endothelin-2 precursor

Size: 178 amino acids; 19960 Da

Subcellular location: Secreted

Secondary accessions: Q5T1R3

Explore the universe of human proteins at neXtProt for EDN2: NX_P20800

EDN2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001947.1

ENSEMBL proteins:

ENSP00000361668

Reactome Protein details: P20800
Human Recombinant Protein Products for EDN2:

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	ProSpec Recombinant Protein for EDN2
	Uscn Proteins for EDN2

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IDA	15691296

EDN2 for ontologies About GeneDecksing

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Assay Products for EDN2:

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	Uscn ELISAs and CLIAs for EDN2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

EDN2 for domains About GeneDecksing

4 InterPro domains/families:

IPR001928 Endothln-like_toxin

IPR020475 Bibrotoxin/Sarafotoxin-D

IPR019764 Endothelin_toxin_CS

IPR015658 ET-2

Graphical View of Domain Structure for InterPro Entry P20800

ProtoNet protein and cluster: P20800

2 Blocks protein families:

IPB003641 Endothelin

IPB003642 Sarafotoxin/bibrotoxin

UniProtKB/Swiss-Prot: EDN2_HUMAN, P20800

Similarity: Belongs to the endothelin/sarafotoxin family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: EDN2_HUMAN, P20800

Function: Endothelins are endothelium-derived vasoconstrictor peptides

Genatlas biochemistry entry for EDN2:

endothelin 2 (vaso-constrictor/pressor peptide),involved in vascular remodeling,commonly expressed in right atrial

tissue,susceptibility gene for essential hypertension

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005179	hormone activity	IDA	2649896

EDN2 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for EDN2:

Decreased telomerase activity

1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Edn2):

no phenotypic analysis

EDN2 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for EDN2

miRNA Products:		OriGene 3'-UTR Clone: EDN2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EDN2
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		hsa-miR-323-3p hsa-let-7f-2*
		SwitchGear 3'UTR luciferase reporter plasmid: EDN2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EDN2 (see all 7) OriGene shRNA RFP: EDN2 OriGene siRNA: EDN2
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		Sirion Biotech Custom design and validation of potent shRNA sequences against EDN2

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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EDN2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EDN2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: EDN2 (NM_001956)
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EDN2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Class A/1 (Rhodopsin-like receptors)

	Class A/1 (Rhodopsin-like receptors)	1.00			Peptide ligand-binding receptors	0.61
	GPCR ligand binding	0.75

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

G alpha (q) signalling events

G alpha (q) signalling events

1.00

Gastrin-CREB signalling pathway via PKC and MAPK

0.90

Selected targets of p53

Selected targets of p53

1.00

Endothelins

Endothelins

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for EDN2

Selected targets of p53

2 BioSystems Pathways for EDN2

	Direct p53 effectors
	Endothelins

5/8 Reactome Pathways for EDN2 (see all 8)

	GPCR downstream signaling
	Peptide ligand-binding receptors
	Gastrin-CREB signalling pathway via PKC and MAPK
	Signaling by GPCR
	GPCR ligand binding

EDN2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for EDN2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/127 Interacting proteins for EDN2 (P20800³ ENSP00000361668⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 127)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
KEL	P23276³, ENSP00000347409⁴	I2D: score=2 STRING: ENSP00000347409
MME	P08473³, ENSP00000353679⁴	I2D: score=2 STRING: ENSP00000353679
CMA1	P23946³, ENSP00000250378⁴	I2D: score=1 STRING: ENSP00000250378
AGTR1	ENSP00000273430⁴	STRING: ENSP00000273430
APP	ENSP00000284981⁴	STRING: ENSP00000284981

About this table

Gene Ontology (GO): 5/26 biological process terms (GO ID links to tree view) (see all 26): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001516	prostaglandin biosynthetic process	IDA	9492062
GO:0001543	ovarian follicle rupture	--	--
GO:0002690	positive regulation of leukocyte chemotaxis	IDA	9696419
GO:0003058	hormonal regulation of the force of heart contraction	TAS	1652300
GO:0003099	positive regulation of the force of heart contraction by chemical signal	TAS	1652300

EDN2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

EDN2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for EDN2 available from Tocris Bioscience About this table

Compound	Action	CAS #
BMS 182874 hydrochloride	Highly selective, orally active non-peptide ETA antagonist	[153042-42-3]
BQ 788 sodium salt	Selective ETB antagonist	[156161-89-6]
IRL-1620	Highly selective ETB agonist	[142569-99-1]
FR 139317	Highly potent, selective ETA antagonist	[142375-60-8]
BQ-123	Selective ETA antagonist	[136553-81-6]

10/38 Novoseek chemical compound relationships for EDN2 gene (see all 38) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
sarafotoxin	91.8	52	2282471 (6), 1725315 (2), 10455253 (2), 9124371 (2) (see all 32)
bq123	86.6	5	8650075 (1), 8717152 (1)
fr139317	83.5	2	9831924 (1)
phosphoramidon	82.9	16	1468574 (3), 8825361 (2), 7864859 (1), 10750028 (1) (see all 8)
thiorphan	75.1	6	8825361 (2), 9110381 (1), 10455291 (1), 7797512 (1)
irl 1620	60.6	1	8650075 (1)
prostacyclin	38.7	4	8401924 (1), 7735698 (1)
inositol triphosphate	32.7	1	8447814 (1)
calcium	31.7	33	8717152 (4), 1407005 (2), 1332876 (2), 8380432 (2) (see all 14)
inositol 1,4,5 trisphosphate	25.7	1	1917960 (1)

Search CenterWatch for drugs/clinical trials and news about EDN2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for EDN2 gene:

NM_001956.3

Unigene Cluster for EDN2:

Endothelin 2

Hs.1407 [show with all ESTs]

Unigene Representative Sequence: BC034393

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000372587(uc001cgu.3 uc001cgv.3 uc009vwh.3 uc001cgw.3 uc009vwi.3 uc009vwj.3 uc001cgx.3)

ENST00000490783 ENST00000467046 ENST00000467872 ENST00000460255

miRNA Products:		OriGene 3'-UTR Clone: EDN2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EDN2
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate EDN2:
		hsa-miR-323-3p hsa-let-7f-2*
		SwitchGear 3'UTR luciferase reporter plasmid: EDN2 3' UTR sequence

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		Sirion Biotech Custom design and validation of potent shRNA sequences against EDN2

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		GenScript: all cDNA clones in your preferred vector: EDN2 (NM_001956)
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Additional cDNA sequence:

BC034393.1 M65199.1 S63833.1 S63834.1 S63835.1 S63836.1 S63837.1 S63838.1

X55177.1

1 DOTS entry:

DT.207009

21 AceView cDNA sequences:

S63836 NM_001956 S63835 AW276532 S63516 AI628621 BX119098 AW452560

BC034393 S63837 X55177 S63834 BI760483 BV199041 BI769422 BI761655

S63833 S63838 M65199 AI140863 AA570005

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for EDN2 (see all 7) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	·	8c
SP1:			-						-		-						-
SP2:									-		-						-
SP3:															-		-
SP4:											-						-
SP5:									-		-

ECgene alternative splicing isoforms for EDN2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

EDN2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTCAGCCAG

About this image

EDN2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Atrioventricular Canal

Atrioventricular Canal Cells

Myocardium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor EN27 (Embryonic Progenitor Cell)

See EDN2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for EDN2

SOURCE GeneReport for Unigene cluster: Hs.1407

UniProtKB/Swiss-Prot: EDN2_HUMAN, P20800

Tissue specificity: Expressed in lung, but not in placental stem villi vessels or cultured placental villi smooth

muscle cells

SABiosciences Expression via Pathway-Focused PCR Arrays including EDN2:

Hypertension in human mouse rat

Endothelial Cell Biology in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EDN2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EDN2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for EDN2 gene from 3/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	EDN2¹	endothelin 2	57.11(n) 51.22(a)		419559 NM_001198655.1 NP_001185584.1
lizard (Anolis carolinensis)	Reptilia	EDN2⁶	--	63(a)	1 ↔ 1	GL343563.1(248769-249330)
zebrafish (Danio rerio)	Actinopterygii	edn2⁶	endothelin 2	37(a)	1 ↔ 1	19(14708747-14714030)

ENSEMBL Gene Tree for EDN2 (if available)
TreeFam Gene Tree for EDN2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for EDN2 gene

EDN1² EDN3²

1 SIMAP similar gene for EDN2 using alignment to 1 protein entry: EDN2_HUMAN:

EDN3

EDN2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs192816533^1,2		--	41944013(+)	`ACCCCC/TCACTG`	1	--	ds500¹		0	--	--	--	--
rs6678343^1,2	C,F,H	--	41944096(+)	`ACTGTC/AAGCCT`	1	--	ds500¹		7		NS EA WA	712
rs184795972^1,2		--	41944139(+)	`CCTCCA/GCCCTC`	1	--	ds500¹		0	--	--	--	--
rs11210262^1,2	C,F,H	--	41944144(-)	`GACACG/CAGGGT`	1	--	ds500¹		13		NS EA NA WA	1360
rs11572376^1,2	C,H	--	41944167(-)	`GGAGCG/ATGTGT`	1	--	ds500¹		5		NS EA	582
rs11572375^1,2	C,F	--	41944168(-)	`AGGAGC/TGTGTG`	1	--	ds500¹		3		NS CSA WA	300
rs6690839^1,2	C,F,A,H	--	41944183(+)	`AAGGGA/CTGGCC`	1	--	ds500¹		35		NS EA NA WA	3802
rs6678569^1,2	C,F	--	41944307(+)	`AGACAC/ACCAGC`	1	--	ds500¹		3		NS WA	280
rs188238121^1,2		--	41944315(+)	`AGCAAA/GGGTGG`	1	--	ds500¹		0	--	--	--	--
rs6678692^1,2	C,F,H	--	41944440(+)	`AAAAAC/ACAGAG`	1	--	ds500¹		14		NS EA NA WA	1662

HapMap Linkage Disequilibrium report for EDN2 (41944446 - 41950344 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for EDN2: --
Human Gene Mutation Database (HGMD): EDN2

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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EDN2 for disorders           About GeneDecksing

OMIM gene information: 131241    OMIM disorders: --

20/31 diseases for EDN2 (see all 31):    About MalaCards

hypertension patent ductus arteriosus primary biliary cirrhosis essential hypertension

atrial fibrillation hypertrophic cardiomyopathy basal cell carcinoma neuronitis

renal cell carcinoma cystic fibrosis pulmonary hypertension aortic disease

ovarian cancer cardiomyopathy breast cancer aldosteronism

pulmonary disease choriocarcinoma sarcoma fibrosis

10/20 Novoseek disease relationships for EDN2 gene (see all 20) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
essential hypertension	37.6	2	10489105 (1)
carcinoma renal cell	26.2	17	1701397 (2), 1722462 (2), 7695628 (2), 1725387 (1) (see all 7)
cardiovascular diseases	23.8	1	10494802 (1)
hypertension pulmonary	16.3	1	10598486 (1)
vascular diseases	8.06	1	16879056 (1)
ewings sarcoma	3.65	1	12193114 (1)
renal failure	0.645	3	16741037 (2)
renal failure chronic	0	3	16741037 (1)
necrosis	0	3	10750028 (2), 9595397 (1)
inflammation	0	1	12184531 (1)

Genetic Association Database (GAD): EDN2
Human Genome Epidemiology (HuGE) Navigator: EDN2 (11 documents)

Export disorders for EDN2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for EDN2 gene, integrated from 9 sources (see all 253):
(articles sorted by number of sources associating them with EDN2)

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cDNA cloning and chromosomal assignment of the endothelin 2 gene: vasoactive intestinal contractor peptide is rat endothelin 2. (PubMed id 1840558)^{1, 2, 9} Bloch K.D.... Quertermous T. (1991)
Expression of endothelin-2 (ET-2) gene in a human renal adenocarcinoma cell line: purification and cDNA cloning of ET-2. (PubMed id 1725387)^{1, 2, 9} Onda H....Fujino M. (1991)
Specific expression of human endothelin-2 (ET-2) gene in a renal adenocarcinoma cell line. Molecular cloning of cDNA encoding the precursor of ET-2 and its characterization. (PubMed id 1701397)^{1, 2, 9} Ohkubo S.... Fujino M. (1990)
Quantitative association between a newly identified molecular variant in the endothelin-2 gene and human essential hypertension. (PubMed id 10489105)^{1, 4, 9} Sharma P....Brown M.J. (1999)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Proteolytic processing of big endothelin-3 by the kell blood group protein. (PubMed id 10438732)^{1, 2} Lee S....Redman C. (1999)
Endothelin-1 and ETA receptor expression in vascular smooth muscle cells from human placenta: a new ETA receptor messenger ribonucleic acid is generated by alternative splicing of exon 3. (PubMed id 9284755)^{1, 2} Bourgeois C.... Ferre F. (1997)
The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. (PubMed id 2649896)^{1, 2} Inoue A....Masaki T. (1989)
Endothelin-2 synthesis is stimulated by the type-1 tumour necrosis factor receptor and cAMP: comparison with endothelin-converting enzyme-1 expression. (PubMed id 10750028)^{1, 9} Lambert G.L....Corder R. (2000)
Endothelin-2 is a macrophage chemoattractant: implications for macrophage distribution in tumors. (PubMed id 12207323)^{1, 9} Grimshaw M.J....Balkwill F.R. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1907	HGNC: 3177	AceView: EDN2	Ensembl:ENSG00000127129	euGenes: HUgn1907
ECgene: EDN2	H-InvDB: EDN2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for EDN2	Pharmacogenomics, SNPs, Pathways
NIEHS-SNPs	http://egp.gs.washington.edu/data/edn2/

Intellectual Property for EDN2 gene
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Patent Information for EDN2 gene:
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