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EDN2 Gene

protein-coding GIFtS: 63

GC01M041717

endothelin 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
ET-2 ^³
ET2 ^¹, ²
OTTHUMP00000007075 ^²
PPET2 ^², ³
Preproendothelin-2 ^³

Descriptions
endothelin 2 ^²
preproendothelin 2 ^²

External Ids
HGNC: 3177¹
Entrez Gene: 1907²
UniProtKB: P20800³
Ensembl: ENSG00000127129⁷

Search outside databases for aliases for EDN2 gene

Previous GC identifers: GC01M041972 GC01M040948 GC01M041407 GC01M041357 GC01M041613

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for EDN2:

This gene encodes a member of the endothelin protein family of secretory vasoconstrictive peptides.

The preproprotein is processed to a short mature form which functions as a ligand for the

endothelin receptors that initiate intracellular signaling events. This gene product is involved

in a wide range of biological processes, such as hypertension and ovulation. [provided by RefSeq]

UniProtKB/Swiss-Prot: EDN2_HUMAN, P20800

Function: Endothelins are endothelium-derived vasoconstrictor peptides

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the EDN2 gene

Entrez Gene cytogenetic band: 1p34 Ensembl cytogenetic band: 1p34.2 HGNC cytogenetic band: 1p34

EDN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M041717: (about GC identifiers)

Start:	41,717,033 bp from pter
End:	41,722,884 bp from pter
Size:	5,852 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000001.9 NT_032977.8

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: EDN2_HUMAN, P20800 (See protein sequence)

Recommended Name: Endothelin-2 precursor

Size: 178 amino acids; 19960 Da

Subcellular location: Secreted

REFSEQ proteins: NP_001947.1

ENSEMBL proteins:

ENSP00000361668

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for EDN2
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (pan Endothelin, Endothelin 2)
	Human Recombinant Proteins from Abnova (EDN2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005615	extracellular space	IDA	15691296

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Antibodies for EDN2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for EDN2
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (pan Endothelin, Endothelin 2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (EDN2)
	Novus Biologicals Antibodies for EDN2

Assays for EDN2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P20800

ProtoNet protein and cluster: P20800

2 Blocks protein families:

IPB003641 Endothelin

IPB003642 Sarafotoxin/bibrotoxin

UniProtKB/Swiss-Prot: EDN2_HUMAN, P20800

Similarity: Belongs to the endothelin/sarafotoxin family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (EDN2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (EDN2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001956

Applied Biosystems Silencer® siRNAs for EDN2

Sigma-Aldrich siRNA for EDN2

Sigma-Aldrich shRNA for EDN2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for EDN2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001956
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001956
untagged cDNA clone in CMV expression vector: NM_001956

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001956

UniProtKB/Swiss-Prot: EDN2_HUMAN, P20800

Function: Endothelins are endothelium-derived vasoconstrictor peptides

Genatlas biochemistry entry for EDN2:

endothelin 2 (vaso-constrictor/pressor peptide),involved in vascular remodeling,commonly expressed

in right atrial tissue,susceptibility gene for essential hypertension

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005179	hormone activity	IDA	2649896
GO:0031708	endothelin B receptor binding	IPI	1713452

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(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/14 Interacting proteins for EDN2 (ENSP00000361668³) via UniProtKB, MINT, and/or STRING (see all 14 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EDNRA	ENSP00000315011³	STRING (score=.998)
EDNRB	ENSP00000366416³	STRING (score=.996)
ECE1	ENSP00000364028³	STRING (score=.918)
EDN1	ENSP00000368683³	STRING (score=.916)
EDN3	ENSP00000360067³	STRING (score=.916)

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5/17 Gene Ontology (GO) biological process terms (links to tree view) (see all 17 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002690	positive regulation of leukocyte chemotaxis	IDA	9696419
GO:0003058	hormonal regulation of the force of heart contraction	TAS	1652300
GO:0003099	positive regulation of the force of heart contraction by chemical signal	TAS	1652300
GO:0003100	regulation of systemic arterial blood pressure by endothelin	IDA	2649896
GO:0007204	elevation of cytosolic calcium ion concentration	IDA	1917960

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for EDN2 available from Tocris Bioscience

Compound	Action	CAS number
BMS 182874 hydrochloride	Highly selective, orally active non-peptide ETA antagonist	[153042-42-3]
BQ 788 sodium salt	Selective ETB antagonist	[156161-89-6]
IRL-1620	Highly selective ETB agonist	[142569-99-1]
FR 139317	Highly potent, selective ETA antagonist	[142375-60-8]
BQ-123	Selective ETA antagonist	[136553-81-6]

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10/22 Novoseek chemical compound relationships for EDN2 gene (see all 22 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
sarafotoxin	91.82	48	2282471 (3), 1725315 (2), 10455253 (2), 9124371 (2) (see all 32)
fr139317	80.89	2	9831924 (1)
irl 1620	61.09	1	8650075 (1)
inositol triphosphate	33.92	1	8447814 (1)
calcium	30.96	33	8717152 (4), 1407005 (2), 1332876 (2), 8380432 (2) (see all 14)
inositol 1,4,5 trisphosphate	26.46	1	1917960 (1)
125i	21.27	3	1843209 (2)
forskolin	19.69	12	9595397 (4), 10750028 (2), 1652300 (1), 7720804 (1)
nitric oxide	19.18	6	15691296 (3), 18838093 (1), 8401924 (1)
cyclic amp	16.93	1	8294922 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (EDN2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (EDN2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001956

Sigma-Aldrich siRNA for EDN2

Sigma-Aldrich shRNA for EDN2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001956

REFSEQ mRNAs for EDN2 gene:

NM_001956.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001956

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001956
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001956
                                 untagged cDNA clone in CMV expression vector: NM_001956

Additional cDNA sequence:

BC034393.1 M65199.1 S63833.1 S63834.1 S63835.1 S63836.1 S63837.1 S63838.1

X55177.1

1 DOTS entry:

DT.207009

21 AceView cDNA sequences:

BC034393 AW276532 BX119098 S63835 S63837 S63516 S63836 AI628621

NM_001956 AW452560 S63838 M65199 BI761655 S63833 BI760483 S63834

BI769422 BV199041 X55177 AI140863 AA570005

highest scoring ESTs for EDN2:

M65199 BC034393 BI760483 X55177 AA570005 AI140863 AI628621 AW276532 AW452560 BI761655

Unigene Cluster for EDN2:

Endothelin 2

Hs.1407 [show with all ESTs]

Unigene Representative Sequence: BC034393

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for EDN2 (see all 7 )

ExUns:	1	^	2a	·	2b	·	2c	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	·	8c
SP1:			-						-		-						-
SP2:									-		-						-
SP3:															-		-
SP4:											-						-
SP5:									-		-

About this scheme

ECgene alternative splicing isoforms for EDN2

1 Ensembl transcript including schematic representation:

ENST00000372587

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

EDN2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for EDN2

¹ / ² / ³

3 probe-sets matching EDN2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1092_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	M65199	1.00	1.00	1.00	1
206758_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001956	0.60	1.00	0.82	1
206758_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks EDN2 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CCTCAGCCAG

SOURCE GeneReport for Unigene cluster: Hs.1407
Expression variation in blood from EXPOLDB for EDN2
UniProtKB/Swiss-Prot: EDN2_HUMAN, P20800
Tissue specificity: Expressed in lung, but not in placental stem villi vessels or cultured
placental villi smooth muscle cells

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for EDN2 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	EDN2¹	--	endothelin 2	79.88(n) 68.05(a)	403508 NM_001003002.1 NP_001003002.1
chimpanzee (Pan troglodytes)	EDN2¹	--	endothelin 2	99.81(n) 99.44(a)	469298 XM_524683.2 XP_524683.2
cow (Bos taurus)	EDN2¹	--	endothelin 2	84(n) 76(a)	319094 NM_175714.2 NP_783645.1
rat (Rattus norvegicus)	Edn2¹	--	endothelin 2	76.95(n) 68(a)	24324 NM_012549.1 NP_036681.1
mouse (Mus musculus)	Edn2^{1, 5}	4⁵	endothelin 2^{1, 5}	78.23(n)¹ 68.79(a)¹	13615¹ NM_007902.2¹ NP_031928.2¹ AB030303⁵ AL607142⁵ (see all 8)

About this table Species with no ortholog for EDN2

ENSEMBL Gene Tree for EDN2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for EDN2 gene

EDN1² EDN3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/117 NCBI SNPs in EDN2 are shown (see all 117 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 86)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs6690839^1,2	A,C,F,H	41716770(+)	`AAGGGA/CTGGCC`	1	--	ng5¹		19	NS EU EA WA NA	1872
	rs11210280^1,2	A,C,F,H	41723100(-)	`TCCATC/ATCCCT`	1	--	ng3¹ trp³		5	NS EU EA WA	560
--	rs11210283^1,2	A,C,F	41724445(-)	`CTGCTC/GTCACC`	1	--	ng3¹		1	NS	178
	rs6678343^1,2	C,F,H	41716683(+)	`ACTGTC/AAGCCT`	1	--	ng5¹		5	NS EU EA WA	590
	rs5798^1,2	C,F,H	41719405(-)	`ACGTGT/CTCCAG`	1	L/F	mis¹ ese³		5	MN EU EA WA	556
	rs3768274^1,2	A,C,F	41723970(-)	`CTGCCG/AGTTCC`	1	--	ng3¹		1	NS	162
	rs581588^1,2	C,F,H	41723532(+)	`AAATGC/TCCCCC`	1	--	ng3¹ tfbs³		7	EA NA NS EU WA	628
	rs6678692^1,2	C,F,H	41717027(+)	`AAAAAC/ACAGAG`	1	--	ng5¹		5	NS EU EA WA	582
	rs5800^1,2	C,F,H	41717277(-)	`TGGAGG/ACTGGA`	1	--	ut3¹		10	NS MN EU EA WA	1168
	rs2984691^1,2	A,C,F	41722899(+)	`GGGAGC/TGCCTG`	1	--	ut5¹		1	NS	150

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HapMap Linkage Disequilibrium images for EDN2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 131241

10/20 Novoseek disease relationships for EDN2 gene (see all 20 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
essential hypertension	35.73	2	10489105 (1)
carcinoma renal cell	27.85	17	1701397 (2), 1722462 (2), 7695628 (2), 1725387 (1) (see all 7)
cardiovascular diseases	24.09	1	10494802 (1)
hypertension pulmonary	18.06	1	10598486 (1)
vascular diseases	9.74	1	16879056 (1)
ewings sarcoma	5.34	1	12193114 (1)
renal failure	2.07	3	16741037 (2)
renal failure chronic	0.00	3	16741037 (1)
necrosis	0.00	3	10750028 (2), 9595397 (1)
melanoma	0.00	1	18758494 (1)

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1 PharmGKB disease relationship for EDN2 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
essential hypertension	CO GN	10489105

About this table

Human Gene Mutation Database: EDN2
Genetic Association Database: EDN2
Human Genome Epidemiology Navigator: EDN2 (3 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/232 PubMed articles for EDN2 gene (see all 232 ):

Quantitative association between a newly identified molecular variant in the endothelin-2 gene and human essential hypertension. (PubMed id 10489105)^{1, 3, 6, 7} Sharma P....Brown M.J. (1999)
cDNA cloning and chromosomal assignment of the endothelin 2 gene: vasoactive intestinal contractor peptide is rat endothelin 2. (PubMed id 1840558)^{1, 3, 4} Bloch K.D.... Quertermous T. (1991)
Expression of endothelin-2 (ET-2) gene in a human renal adenocarcinoma cell line: purification and cDNA cloning of ET-2. (PubMed id 1725387)^{1, 3, 4} Onda H....Fujino M. (1991)
Specific expression of human endothelin-2 (ET-2) gene in a renal adenocarcinoma cell line. Molecular cloning of cDNA encoding the precursor of ET-2 and its characterization. (PubMed id 1701397)^{1, 3, 4} Ohkubo S.... Fujino M. (1990)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Endothelin-1 and ETA receptor expression in vascular smooth muscle cells from human placenta: a new ETA receptor messenger ribonucleic acid is generated by alternative splicing of exon 3. (PubMed id 9284755)^{3, 4} Bourgeois C.... Ferre F. (1997)
The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. (PubMed id 2649896)^{3, 4} Inoue A....Masaki T. (1989)
Endothelin-2 synthesis is stimulated by the type-1 tumour necrosis factor receptor and cAMP: comparison with endothelin-converting enzyme-1 expression. (PubMed id 10750028)^{1, 3} Lambert G.L....Corder R. (2000)
Endothelin-2 is a macrophage chemoattractant: implications for macrophage distribution in tumors. (PubMed id 12207323)^{1, 3} Grimshaw M.J....Balkwill F.R. (2002)
Immunoreactive endothelin-1, endothelin-2 and big endothelin-1 in follicular fluids of women undergoing ovulation induction for in-vitro fertilization. (PubMed id 8671207)^{1, 3} Haq A....al-Sedairy S.T. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 1907	HGNC: 3177	AceView: EDN2	Ensembl:ENSG00000127129	euGenes: HUgn1907
ECgene: EDN2	H-InvDB: EDN2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
NIEHS-SNPs	http://egp.gs.washington.edu/data/edn2/

Licensable Technologies for EDN2
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for EDN2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for EDN2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for EDN2		Antibodies for EDN2
	Explore super-pooled esiRNAs		Proteins for EDN2
	Lentivirus-delivered shRNAs for EDN2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (EDN2)
	Antibodies (EDN2)
	Chimera RNAi (EDN2)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (pan Endothelin, Endothelin 2)
	Antibodies (pan Endothelin, Endothelin 2)

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Tocris compounds for EDN2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for EDN2

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EDN2 Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for EDN2

Summaries
for EDN2

Genomic Location
for EDN2

Proteins
for EDN2

Protein Domains/
Families
for EDN2

Gene Function
for EDN2

Pathways & Interactions
for EDN2

Drugs & Compounds
for EDN2

Transcripts
for EDN2

Expression
for EDN2

Orthologs
for EDN2

Paralogs
for EDN2

SNPs/Variants
for EDN2

Disorders & Mutations
for EDN2

Medical News
for EDN2

Publications
for EDN2

Search for EDN2

Genome Databases showing EDN2

Other Databases showing EDN2

Specialized Databases showing EDN2

Licensable Technologies
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Services
for EDN2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

EDN2 Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor EDN2

Summariesfor EDN2

Genomic Locationfor EDN2

Proteinsfor EDN2

Protein Domains/Familiesfor EDN2

Gene Functionfor EDN2

Pathways & Interactionsfor EDN2

Drugs & Compoundsfor EDN2

Transcriptsfor EDN2

Expression for EDN2

Orthologsfor EDN2

Paralogsfor EDN2

SNPs/Variantsfor EDN2

Disorders & Mutationsfor EDN2

Medical Newsfor EDN2

Publicationsfor EDN2

Search for EDN2

Genome Databases showing EDN2

Other Databases showing EDN2

Specialized Databases showing EDN2

Licensable Technologiesfor EDN2

Servicesfor EDN2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for EDN2

Summaries
for EDN2

Genomic Location
for EDN2

Proteins
for EDN2

Protein Domains/
Families
for EDN2

Gene Function
for EDN2

Pathways & Interactions
for EDN2

Drugs & Compounds
for EDN2

Transcripts
for EDN2

Expression
for EDN2

Orthologs
for EDN2

Paralogs
for EDN2

SNPs/Variants
for EDN2

Disorders & Mutations
for EDN2

Medical News
for EDN2

Publications
for EDN2

Licensable Technologies
for EDN2

Services
for EDN2