Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

EDN1 Gene

protein-coding GIFtS: 69
GCID: GC06P012290

endothelin 1

Explore 308 diseases affiliated with
EDN1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Endothelin 1¹ ²		Endothelin-1¹
ET1¹ ²		Preproendothelin-1³
PPET1² ³		Preproendothelin-1³
HDLCQ7² ⁵

External Ids:	HGNC: 3176¹	Entrez Gene: 1906²	Ensembl: ENSG00000078401⁷	OMIM: 131240⁵	UniProtKB: P05305³

Export aliases for EDN1 gene to outside databases

Previous GC identifers: GC06P012348 GC06P012398

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for EDN1:

The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This

peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 also can affect the

central nervous system. Two transcript variants encoding different isoforms have been found for this gene. (provided

by RefSeq, Nov 2009)

UniProtKB/Swiss-Prot: EDN1_HUMAN, P05305

Function: Endothelins are endothelium-derived vasoconstrictor peptides

summary for EDN1:

The endothelin family consists of highly potent vasoconstrictive peptides. Three endogenous isoforms are

known to exist, ET-1, ET-2 and ET-3, and two distinct endothelin receptors have so far been cloned in

mammals, classified as ETA and ETB receptors. Endothelin receptors are widely expressed in all tissues,

which is consistent with their physiological role as vasoactive peptides. They are also localized to

non-vascular structures including epithelial cells, glia and neurons. The principle physiological role of

endothelin receptors is the maintenance of vascular tone. They also have co-mitogenic activity, potentiating

the effects of other growth factors such as PDGF.

Gene Wiki entry for EDN1 (Endothelin 1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_007592.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the EDN1 gene promoter:
FOXI1 GATA-6 p53 Nkx2-5 NF-kappaB1 NF-kappaB
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): EDN1 promoter sequence

Search SABiosciences Chromatin IP Primers for EDN1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EDN1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p24.1 Ensembl cytogenetic band: 6p24.1 HGNC cytogenetic band: 6p24.1

EDN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EDN1 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P012290: view genomic region (about GC identifiers)

Start:	12,290,529 bp from pter	End:	12,297,427 bp from pter
Size:	6,899 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: EDN1_HUMAN, P05305 (See protein sequence)

Recommended Name: Endothelin-1 precursor

Size: 212 amino acids; 24425 Da

Subcellular location: Secreted

4 PDB 3D structures from and Proteopedia for EDN1:

1EDN (3D)

1EDP (3D)

1T7H (3D)

1V6R (3D)

Secondary accessions: Q96DA1

Explore the universe of human proteins at neXtProt for EDN1: NX_P05305

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P05305

EDN1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001161791.1 NP_001946.3

ENSEMBL proteins:

ENSP00000368683

Reactome Protein details: P05305
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for EDN1
	OriGene Purified Protein: EDN1 OriGene Protein Over-expression Lysate (see all 2): EDN1 OriGene Custom Protein Services for EDN1
	GenScript Custom Purified and Recombinant Proteins Services for EDN1
	Novus Biologicals EDN1 Proteins Novus Biologicals EDN1 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for EDN1
	Uscn Proteins for EDN1

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IDA	15691296
GO:0005737	cytoplasm	IDA	12379507

EDN1 for ontologies About GeneDecksing

EDN1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of EDN1
	R&D Systems Antibodies for EDN1 (Endothelin-1)
	OriGene Antibodies: EDN1 OriGene Custom Antibody Services for EDN1
	GenScript Custom Superior Antibodies Services for EDN1
	Novus Biologicals EDN1 Antibodies
	Search for Antibodies for EDN1 at Abcam
	Uscn Antibodies for EDN1
	ThermoFisher Antibody for EDN1

Assay Products for EDN1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for EDN1 (Endothelin-1) (see all)
	GenScript Custom Assay Services for EDN1
	Enzo Life Sciences assays for EDN1
	Uscn ELISAs and CLIAs for EDN1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

EDN1 for domains About GeneDecksing

3 InterPro domains/families:

IPR001928 Endothln-like_toxin

IPR020475 Bibrotoxin/Sarafotoxin-D

IPR019764 Endothelin_toxin_CS

Graphical View of Domain Structure for InterPro Entry P05305

ProtoNet protein and cluster: P05305

1 Blocks protein family: IPB003641 Endothelin

UniProtKB/Swiss-Prot: EDN1_HUMAN, P05305

Similarity: Belongs to the endothelin/sarafotoxin family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: EDN1_HUMAN, P05305

Function: Endothelins are endothelium-derived vasoconstrictor peptides

Genatlas biochemistry entry for EDN1:

endothelin 1 (vaso-constrictor/pressor peptide),phospholipase C activator,interacting with I16 for induced expression

of fetal genes in cardiac myocytes

Summary:

During embryonic development, EDN1 as signaling molecule is secreted from the following cells: Branchial Arch 1 Ectoderm Cells in Branchial Arch 1, Branchial Arch 2 Ectoderm Cells in Branchial Arch 2

It affects the following cells: Cardiac Neural Crest Cells in Branchial Arch 3,4,6, Cranial Neural Crest Cells in Branchial Arch 1 (see all 4).

miRNA Products:		miRTarBase miRNAs that target EDN1: hsa-mir-199a-5p (MIRT005432), hsa-mir-155 (MIRT004455)

		OriGene 3'-UTR Clone: EDN1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EDN1
		8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate EDN1 (see all 26):
		hsa-miR-3673 hsa-let-7d hsa-miR-4328 hsa-miR-202 hsa-miR-301a hsa-let-7c hsa-let-7g hsa-miR-629*

		SwitchGear 3'UTR luciferase reporter plasmid: EDN1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EDN1 (see all 7) OriGene shRNA RFP: EDN1 OriGene siRNA: EDN1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EDN1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for EDN1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EDN1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EDN1 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): EDN1 (NM_001168319)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for EDN1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EDN1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for EDN1
		Search LifeMap BioReagents cell lines for EDN1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EDN1

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005102	receptor binding	--	--
GO:0005125	cytokine activity	IDA	19767294
GO:0005179	hormone activity	IDA	2649896
GO:0005515	protein binding	--	--
GO:0031707	endothelin A receptor binding	IDA	10770212

EDN1 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for EDN1: Edn1^tm1Utj Edn1^tm1.1Ywa
     13 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Edn1):

cardiovascular system	craniofacial	digestive/alimentary	embryogenesis	endocrine/exocrine gland
hearing/vestibular/ear	homeostasis/metabolism	mortality/aging	muscle	nervous system
no phenotypic analysis	renal/urinary system	skeleton

EDN1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/17 super-pathways (see all 17) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Development_Endothelin-1/EDNRA transactivation of EGFR

	Development_Endothelin-1/EDNRA transactivation of EGFR	1.00			Development Endothelin-1/EDNRA signaling	0.41
	Development Endothelin-1/EDNRA transactivation of EGFR	1.00			Development_Endothelin-1/EDNRA signaling	0.41

Class A/1 (Rhodopsin-like receptors)

	Class A/1 (Rhodopsin-like receptors)	1.00			Peptide ligand-binding receptors	0.61
	GPCR ligand binding	0.75

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

Immune response_IL-1 signaling pathway

Immune response_IL-1 signaling pathway

1.00

Immune response IL-1 signaling pathway

0.98

G alpha (q) signalling events

G alpha (q) signalling events

1.00

Gastrin-CREB signalling pathway via PKC and MAPK

0.90

Pathway sources
See GeneCards unified pathways
Show all pathways

5 EMD Millipore Pathways for EDN1

	Development EDNRB signaling
	Development Leptin signaling via JAK/STAT and MAPK cascades
	Development Endothelin-1/EDNRA signaling
	Development Endothelin-1/EDNRA transactivation of EGFR
	Immune response IL-1 signaling pathway

3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for EDN1

	Endothelin-1 Signaling Pathway
	HIF1Alpha Pathway
	NFAT and Cardiac Hypertrophy

5 GeneGo (Thomson Reuters) Pathways for EDN1

	Development Leptin signaling via JAK/STAT and MAPK cascades
	Development Endothelin-1/EDNRA transactivation of EGFR
	Development EDNRB signaling
	Development Endothelin-1/EDNRA signaling
	Immune response IL-1 signaling pathway

5/6 BioSystems Pathways for EDN1 (see all 6)

	MicroRNAs in cardiomyocyte hypertrophy
	Endothelin
	Prostaglandin Synthesis and Regulation
	HIF-1-alpha transcription factor network
	Endothelins

5/8 Reactome Pathways for EDN1 (see all 8)

	GPCR downstream signaling
	Peptide ligand-binding receptors
	Gastrin-CREB signalling pathway via PKC and MAPK
	Signaling by GPCR
	GPCR ligand binding

1 Kegg Pathway (Kegg details for EDN1):

Melanogenesis

EDN1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for EDN1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/163 Interacting proteins for EDN1 (P05305^{2, 3} ENSP00000368683⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 163)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BAG6	P46379²^,³	MINT-63406 I2D: score=5
COPS6	Q7L5N1²^,³	MINT-63405 I2D: score=5
UBQLN4	Q9NRR5²^,³, ENSP00000357292⁴	MINT-2858310 I2D: score=3 STRING: ENSP00000357292
ADM	P35318³, ENSP00000278175⁴	I2D: score=1 STRING: ENSP00000278175
KEL	P23276³, ENSP00000347409⁴	I2D: score=1 STRING: ENSP00000347409

About this table

Gene Ontology (GO): 5/83 biological process terms (GO ID links to tree view) (see all 83): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IDA	19767294
GO:0001501	skeletal system development	--	--
GO:0001516	prostaglandin biosynthetic process	IDA	9492062
GO:0001569	patterning of blood vessels	IEA	--
GO:0001666	response to hypoxia	IEA	--

EDN1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

EDN1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for EDN1

Compounds for EDN1 available from Tocris Bioscience About this table

Compound	Action	CAS #
BMS 182874 hydrochloride	Highly selective, orally active non-peptide ETA antagonist	[153042-42-3]
BQ 788 sodium salt	Selective ETB antagonist	[156161-89-6]
IRL-1620	Highly selective ETB agonist	[142569-99-1]
FR 139317	Highly potent, selective ETA antagonist	[142375-60-8]
BQ-123	Selective ETA antagonist	[136553-81-6]

1 HMDB Compound for EDN1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Nitric oxide	Mononitrogen monoxide (see all 9)	10102-43-9	--

10/138 Novoseek chemical compound relationships for EDN1 gene (see all 138) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
bq123	91.8	135	8735635 (4), 11687541 (3), 10604982 (2), 12193073 (2) (see all 86)
sarafotoxin	91.3	241	7889304 (7), 8287917 (3), 8587426 (3), 12193054 (3) (see all 99)
bq788	89.3	77	16318777 (3), 15765100 (3), 9595416 (2), 9846633 (2) (see all 52)
bosentan	86.4	119	17322637 (6), 19477379 (4), 8587420 (4), 8823230 (3) (see all 54)
phosphoramidon	85	261	7510004 (8), 7550091 (7), 8406292 (6), 8528566 (6) (see all 80)
fr139317	81	36	8032583 (3), 9831924 (3), 9595416 (2), 9846633 (2) (see all 21)
nitric oxide	80.9	2131	14526432 (11), 14695117 (8), 18001528 (8), 17361520 (8) (see all 99)
bq 3020	79	8	15075338 (3), 10822048 (2), 7647976 (1), 7679333 (1) (see all 5)
bq610	77.9	12	10218898 (1), 7796447 (1), 10445306 (1), 8631621 (1) (see all 10)
prostacyclin	77.5	354	15300217 (6), 8751735 (6), 9423756 (6), 7775630 (6) (see all 99)

1 PharmGKB related drug/compound annotation for EDN1 gene

Drug/compound	PharmGKB Annotation
muraglitazar	CA

About this table

Search CenterWatch for drugs/clinical trials and news about EDN1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for EDN1 gene (2 alternative transcripts):

NM_001168319.1 NM_001955.4

Unigene Clusters for EDN1:

Endothelin 1

Hs.511899 [show with all ESTs], Hs.713645 [show with all ESTs]

Unigene Representative Sequences: NM_001955, BC036851

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000379375(uc010jpb.3 uc003nad.3 uc003naf.4 uc003nae.4)

miRNA Products:		OriGene 3'-UTR Clone: EDN1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EDN1
		8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate EDN1 (see all 26):
		hsa-miR-3673 hsa-let-7d hsa-miR-4328 hsa-miR-202 hsa-miR-301a hsa-let-7c hsa-let-7g hsa-miR-629*

		SwitchGear 3'UTR luciferase reporter plasmid: EDN1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EDN1 (see all 7) OriGene shRNA RFP: EDN1 OriGene siRNA: EDN1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EDN1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EDN1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EDN1 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): EDN1 (NM_001168319)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for EDN1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EDN1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EDN1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat EDN1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EDN1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EDN1

Additional cDNA sequence: BC036851.1

5 DOTS entries:

DT.215144 DT.99934348 DT.91949623 DT.100777041 DT.121310909

24/143 AceView cDNA sequences (see all 143):

AI126868 T27748 CB105599 CR591383 AA937140 CA309734 BM680754 BQ185104

AW043551 BM977229 CB105582 AA663956 F02908 BQ009676 CA306604 CR605456

BU676234 CB105477 CA426258 BM671893 AA302119 BM974937 CB105976 AW044634

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for EDN1 About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4a	·	4b	^	5
SP1:							-
SP2:							-
SP3:

ECgene alternative splicing isoforms for EDN1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

EDN1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTTGTTTTG

About this image

EDN1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/12 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 12)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Head Mesenchyme

Branchial Arch 1

Branchial Arch 1 Ectoderm Cells

Ectoderm, Epidermis

Head Mesenchyme

Branchial Arch 2

Branchial Arch 2 Ectoderm Cells

Ectoderm, Epidermis

Endocardium

Midgut Endoderm Cells

Endoderm

Spinal Cord

Spinal Dorsal Columns

Dorsal Spinal Cord Progenitor Cells

Spinal Cord

Spinal Ventral Columns

Ventral Spinal Cord Progenitor Cells

Motor Neurons

Brain

Gut Tube

Neural Tube

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 10/13 LifeMap Cells (see all 13)

Name

Category

PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)

Endothelium

PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)

Endothelium

PureStem™ progenitor E68 (Embryonic Progenitor Cell)

PureStem™ progenitor T42 (Embryonic Progenitor Cell)

PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)

Endothelium

PureStem™ progenitor EN2 (Embryonic Progenitor Cell)

PureStem™ progenitor T36 (Embryonic Progenitor Cell)

PureStem™ progenitor U31 (Embryonic Progenitor Cell)

See EDN1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for EDN1

SOURCE GeneReport for Unigene clusters: Hs.511899 Hs.713645

UniProtKB/Swiss-Prot: EDN1_HUMAN, P05305

Tissue specificity: Expressed in lung, placental stem villi vessels and in cultured placental vascular smooth muscle

cells

SABiosciences Expression via Pathway-Focused PCR Arrays including EDN1 (see all 9):

G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat

Fibrosis in human mouse rat

Hypoxia Signaling Pathway in human mouse rat

Angiogenesis in human mouse rat

Stress & Toxicity PathwayFinder in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EDN1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat EDN1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EDN1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EDN1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EDN1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for EDN1 gene from 3/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	EDN1¹	endothelin 1	61.11(n) 51.08(a)		420854 XM_418943.3 XP_418943.2
lizard (Anolis carolinensis)	Reptilia	EDN1⁶	--	48(a)	1 ↔ 1	GL343209.1(3436737-3444682)
zebrafish (Danio rerio)	Actinopterygii	edn1¹	endothelin 1	55.84(n) 52.14(a)		58032 NM_131519.1 NP_571594.1

ENSEMBL Gene Tree for EDN1 (if available)
TreeFam Gene Tree for EDN1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for EDN1 gene

EDN2² EDN3²

1 SIMAP similar gene for EDN1 using alignment to 2 protein entries: EDN1_HUMAN (see all proteins):

EDN3

EDN1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs5370^1,2	C,F,A,H,	other	12227880(+)	`GGCAAG/TCCCTC`	4	K N	mis¹ ese³		39		MN EA NS NA WA EU	11665
rs73722759^1,2	C,F,	--	12220226(+)	`CCTCTG/CCTCTC`	2	--	us2k¹		2		WA CSA	4
rs3756864^1,2	C,	--	12220240(-)	`AAAGCC/TGACCT`	2	--	us2k¹		0	--	--	--	--
rs10478687^1,2	C	--	12220666(+)	`AAAAAG/TGTTTC`	2	--	us2k¹ trp³		1		NS	150
rs10478688^1,2	C,F	--	12220732(+)	`CCATCC/TCCAGA`	2	--	us2k¹		1		NS	164
rs1800784^1,2	C,F,A,H,	--	12220822(+)	`TCCCAT/AAGGTC`	2	--	us2k¹		3		NS WA NA	404
rs1800785^1,2	C,F,A,H,	--	12220824(+)	`CCATAG/AGTCTT`	2	--	us2k¹		9		NS WA NA	880
rs10478692^1,2	C,F,H,	--	12221021(+)	`TTAGAT/CAGACA`	2	--	us2k¹		10		NS EA NA WA	1016
rs72830019^1,2		--	12221527(+)	`ACTTAC/TCGGGG`	2	--	us2k¹		0	--	--	--	--
rs10478698^1,2	C,F,	--	12222807(+)	`ATTATT/GATTCC`	2	--	int¹		3		NS NA EA	416

HapMap Linkage Disequilibrium report for EDN1 (12290529 - 12297427 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for EDN1: --
Human Gene Mutation Database (HGMD): EDN1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EDN1

DNA2.0 Custom Variant and Variant Library Synthesis for EDN1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

EDN1 for disorders           About GeneDecksing

OMIM gene information: 131240    OMIM disorders: --

20/308 diseases for EDN1 (see all 308):    About MalaCards

high density lipoprotein cholesterol level qtl 7 twin-to-twin transfusion syndrome low tension glaucoma open-angle glaucoma

cor pulmonale twin twin transfusion syndrome spinal cord injury high blood pressure

low renin hypertension disseminated intravascular coagulation primary open angle glaucoma sudden infant death syndrome

end stage renal failure atrioventricular septal defect homocysteine plasma level doxorubicin induced cardiomyopathy

complex regional pain syndrome cleft lip/palate proliferative diabetic retinopathy focal segmental glomerulosclerosis

12 diseases from the University of Copenhagen DISEASES database for EDN1:

Hypertension Heart disease Atherosclerosis Kidney failure

Portal hypertension Diabetes mellitus Cerebrovascular accident Systemic scleroderma

Glaucoma Liver cirrhosis Proteinuria Asthma

10/97 Novoseek disease relationships for EDN1 gene (see all 97) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hypertension pulmonary	79	355	8594905 (6), 16864942 (4), 10625089 (4), 19632577 (4) (see all 99)
vasospasm	72.6	99	9254095 (6), 12910400 (4), 11053063 (3), 14623768 (3) (see all 58)
hypertension arterial	68.8	71	11675821 (3), 12628956 (2), 19632577 (2), 18925520 (2) (see all 47)
atherosclerosis	66.7	235	11755940 (4), 9647335 (4), 15320823 (4), 18673159 (4) (see all 99)
essential hypertension	66.7	149	9283062 (6), 10522417 (4), 12425201 (3), 19644593 (3) (see all 71)
heart failure	65.1	290	8176102 (6), 9861298 (5), 16076689 (5), 8606275 (4) (see all 99)
pulmonary hypertension secondary	64.1	13	10194659 (2), 18211765 (1), 8594905 (1), 10444023 (1) (see all 11)
cardiovascular diseases	62.8	117	17617392 (2), 20217138 (2), 19057845 (2), 11078363 (2) (see all 80)
cerebral vasospasm	61.3	47	10713190 (4), 11340231 (3), 10763512 (3), 15104415 (2) (see all 27)
preeclampsia	60.7	244	19730395 (6), 11167202 (5), 12193142 (5), 17261879 (5) (see all 84)

Genetic Association Database (GAD): EDN1
Human Genome Epidemiology (HuGE) Navigator: EDN1 (137 documents)

Export disorders for EDN1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for EDN1 gene, integrated from 9 sources (see all 3937):
(articles sorted by number of sources associating them with EDN1)

Utopia: connect your pdf to the dynamic
world of online information

Evaluation of the Lys198Asn and -134delA genetic polymorphisms of the endothelin-1 gene. (PubMed id 15198485)^{1, 4, 9} Tanaka C....Miyata T. (2004)
[Correlation between polymorphism of TaqI of ET-1 gene and cirrhotic portal hypertension] (PubMed id 12887757)^{1, 4, 9} Lin J.S....Xiong P. (2003)
Genes encoding endothelin-converting enzyme-1 and endothelin-1 interact to influence blood pressure in women: the EVA study. (PubMed id 15126915)^{1, 4, 9} Funalot B....Ducimetiere P. (2004)
Association between glaucoma and gene polymorphism of endothelin type A receptor. (PubMed id 15988412)^{1, 4, 9} Ishikawa K....Mashima Y. (2005)
[Relationship of endothelin-1 (ET-1) TaqI and tumor necrosis factor (TNF) a gene polymorphism with portal hypertension in liver cirrhosis.] (PubMed id 15623376)^{1, 4, 9} Cheng Y.Q....Xiong P. (2004)
The double heterozygote of two endothelin-1 gene polymorphisms (G8002A and -3A/-4A) is related to big endothelin levels in chronic heart failure. (PubMed id 12565798)^{1, 4, 9} Vasku A....Vacha J. (2002)
Association between the endothelin-1 gene Lys198Asn polymorphism blood pressure and plasma endothelin-1 levels in normal and pre-eclamptic pregnancy. (PubMed id 11593097)^{1, 4, 9} Barden A.E....Van Bockxmeer F.M. (2001)
Gender-specific association between preproendothelin-1 genotype and reduction of systolic blood pressure during antihypertensive treatment--results from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation versus Atenolol (SILVHIA). (PubMed id 15188945)^{1, 4, 9} Hallberg P....Melhus H. (2004)
Endothelin-1 gene and progression of blood pressure and left ventricular mass: longitudinal findings in youth. (PubMed id 15505112)^{1, 4, 9} Dong Y....Snieder H. (2004)
Endothelin-1 gene polymorphism in patients with malignant arrhythmias. (PubMed id 15838369)^{1, 4, 9} Kozak M....Vacha J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1906	HGNC: 3176	AceView: EDN1	Ensembl:ENSG00000078401	euGenes: HUgn1906
ECgene: EDN1	Kegg: 1906	H-InvDB: EDN1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for EDN1	Pharmacogenomics, SNPs, Pathways
NIEHS-SNPs	http://egp.gs.washington.edu/data/edn1/
R&D Systems' cytokine source book: Endothelin-1	http://www.rndsystems.com/molecule_detail.aspx?m=1364
Wikipedia	http://en.wikipedia.org/wiki/Endothelin

Intellectual Property for EDN1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for EDN1 gene:
Search GeneIP for patents involving EDN1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	Browse Kits and Assays available from EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of EDN1
	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore
	Browse Small Molecules at EMD Millipore
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for EDN1 (Endothelin-1)		Browse Cell Culture Products
	ELISAs for EDN1 (Endothelin-1)		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Multiplex/Array Assay Kits/Reagents for EDN1 (Endothelin-1)
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for EDN1		OriGene shRNA RFP for EDN1
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EDN1		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EDN1
	OriGene Protein Over-expression Lysate for EDN1		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for EDN1		OriGene 3'-UTR Clone for EDN1
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EDN1		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EDN1
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for EDN1		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for EDN1		OriGene Custom Protein Services for EDN1
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat EDN1
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EDN1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EDN1
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EDN1
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EDN1
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EDN1

	GenScript Custom Purified and Recombinant Proteins Services for EDN1		GenScript cDNA clones with any tag delivered in your preferred vector for EDN1
	GenScript Custom Assay Services for EDN1		GenScript Custom Superior Antibodies Services for EDN1
	GenScript Custom overexpressing Cell Line Services for EDN1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in EDN1 promoter
	Search Chromatin IP Primers for EDN1
	RT² qPCR Primer Assay in human, mouse, rat EDN1
	GNC Network for EDN1
	SABiosciences PCR Arrays including human, mouse, rat EDN1

Tocris compounds for EDN1

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

	Assays/Drugs/Proteins for EDN1
	Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	EDN1 antibodies
	EDN1 proteins
	EDN1 lysates

	Search for Antibodies for EDN1 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for EDN1
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Recombinant Protein for EDN1

EDN1 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for EDN1

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EDN1

	SwitchGear 3'UTR luciferase reporter plasmids for EDN1
	SwitchGear Promoter luciferase reporter plasmids for EDN1

ThermoFisher Antibody for EDN1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EDN1

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes EDN1 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

EDN1 Gene

endothelin 1

Aliases
for EDN1 gene

Summaries
for EDN1 gene

Genomic Views
for EDN1 gene

Proteins
for EDN1 gene

Protein Domains /
Families
for EDN1 gene

Function
for EDN1 gene

Pathways & Interactions
for EDN1 gene

Drugs & Compounds
for EDN1 gene

Transcripts
for EDN1 gene

Expression
for EDN1 gene

Orthologs
for EDN1 gene

Paralogs
for EDN1 gene

Genomic Variants
for EDN1 gene

Disorders / Diseases
for EDN1 gene

Publications
for EDN1 gene

External Searches for EDN1 gene

Genome Databases showing EDN1 gene

Other Databases showing EDN1 gene

Specialized Databases showing EDN1 gene

Intellectual Property
for EDN1 gene

Products
for EDN1 gene

View Random Gene

Microalbuminuria
COR PULMONALE CHRONIC
Hyperinsulinemia
essential hypertension
Raynauds Phenomenon
Acute myocardial infarction
Low tension glaucoma
insulin sensitivity
Myocardial Ischemia
Primary pulmonary hypertension
Ischemia
Atherosclerosis
Neovascularization
Hypercholesterolemia
Asthma
ovarian carcinoma metastatic
CONGENITAL HEART DISEASE
cell damage
Hypertension Pulmonary
Hypotension
Coronary Atherosclerosis
Cardiomyopathy
Cor Pulmonale
Hyperpigmentation
RENAL DISEASE
Bronchoalveolar Lavage Fluid
Coronary Vasospasm
Inflammation
glomerulosclerosis
Diabetic Nephropathies
Proteinuria
Microangiopathy Diabetic
SICKLE CELL DISEASE
Hypertrophy
Neuroepithelioma
Renal Failure
aqueous humor
Cardiovascular Diseases
PULMONARY HYPERTENSION SECONDARY
Necrosis
Liver Cirrhosis
Hypertension Renal
Preeclampsia
Coronary Heart Disease
FIBROSIS IDIOPATHIC PULMONARY
Cirrhosis
Myocardial Diseases Primary
HYPERTENSION ARTERIAL
Pulmonary Fibrosis
glaucoma
malignant hemangioendothelioma
Raynauds syndrome
atherosclerotic plaque
Optic Neuropathy
Lung Diseases Interstitial
Diabetic Angiopathies
Vasospasm
VASCULAR RING
Diabetes Mellitus
Erectile Dysfunction
low renin hypertension
Ventricular Dysfunction Left
Heart Failure Congestive
Subarachnoid Hemorrhage
VENOUS OCCLUSION
systemic hypertension
Arteriosclerosis
Effects Cardiovascular
Connective Tissue Diseases
Hepatorenal Syndrome
Myocardial Infarction
HEART FAILURE
Coronary Artery Disease
Hypertension Portal
VARIANT ANGINA
Proliferative diabetic retinopathy
Insulin Resistance
Subarachnoid Hemorrhage Aneurysmal
OVARIAN CARCINOMA
Cerebral Vasospasm
Lung diseases
Cardiac Hypertrophy
Lentigo
ventricular hypertrophy
associated conditions
fluid retention
Vascular Diseases
Meconium aspiration syndrome
CRESCENDO ANGINA
reactive hyperemia
NIDDM
Syndrome X
Sclerosis Systemic
CORONARY SPASM
Dilated Cardiomyopathy
bone metastases
Renal Failure Chronic

Advanced Search

Export list of displayed genes

EDN1 Gene

endothelin 1

Aliasesfor EDN1 gene

Summariesfor EDN1 gene

Genomic Viewsfor EDN1 gene

Proteinsfor EDN1 gene

Protein Domains /Familiesfor EDN1 gene

Functionfor EDN1 gene

Pathways & Interactionsfor EDN1 gene

Drugs & Compoundsfor EDN1 gene

Transcriptsfor EDN1 gene

Expression for EDN1 gene

Orthologsfor EDN1 gene

Paralogsfor EDN1 gene

Genomic Variantsfor EDN1 gene

Disorders / Diseasesfor EDN1 gene

Publicationsfor EDN1 gene

External Searches for EDN1 gene

Genome Databases showing EDN1 gene

Other Databases showing EDN1 gene

Specialized Databases showing EDN1 gene

Intellectual Propertyfor EDN1 gene

Productsfor EDN1 gene

View Random Gene

Aliases
for EDN1 gene

Summaries
for EDN1 gene

Genomic Views
for EDN1 gene

Proteins
for EDN1 gene

Protein Domains /
Families
for EDN1 gene

Function
for EDN1 gene

Pathways & Interactions
for EDN1 gene

Drugs & Compounds
for EDN1 gene

Transcripts
for EDN1 gene

Expression
for EDN1 gene

Orthologs
for EDN1 gene

Paralogs
for EDN1 gene

Genomic Variants
for EDN1 gene

Disorders / Diseases
for EDN1 gene

Publications
for EDN1 gene

Intellectual Property
for EDN1 gene

Products
for EDN1 gene