Aliases for EDN1 Gene
External Ids for EDN1 Gene
Previous GeneCards Identifiers for EDN1 Gene
The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 also can affect the central nervous system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]
GeneCards Summary for EDN1 Gene
EDN1 (Endothelin 1) is a Protein Coding gene. Diseases associated with EDN1 include auriculocondylar syndrome 3 and question mark ears, isolated. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include cytokine activity and endothelin A receptor binding. An important paralog of this gene is EDN2.
UniProtKB/Swiss-Prot for EDN1 Gene
Endothelins are endothelium-derived vasoconstrictor peptides
The endothelin family consists of highly potent vasoconstrictive peptides. Three endogenous isoforms are known to exist, ET-1, ET-2 and ET-3, and two distinct endothelin receptors have so far been cloned in mammals, classified as ETA and ETB receptors. Endothelin receptors are widely expressed in all tissues, which is consistent with their physiological role as vasoactive peptides. They are also localized to non-vascular structures including epithelial cells, glia and neurons. The principle physiological role of endothelin receptors is the maintenance of vascular tone. They also have co-mitogenic activity, potentiating the effects of other growth factors such as PDGF.