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EDN1 Gene

protein-coding GIFtS: 66

GC06P012398

endothelin 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
ET1 ^¹, ²
HDLCQ7 ^², ⁵
OTTHUMP00000016038 ^²
OTTHUMP00000039245 ^²
PPET1 ^³
Preproendothelin-1 ^³

Descriptions
endothelin 1 ^²

External Ids
HGNC: 3176¹
Entrez Gene: 1906²
UniProtKB: P05305³
Ensembl: ENSG00000078401⁷

Search outside databases for aliases for EDN1 gene

Previous GC identifer: GC06P012348

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: EDN1_HUMAN, P05305

Function: Endothelins are endothelium-derived vasoconstrictor peptides

Gene Wiki entry for EDN1 (Endothelin_1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the EDN1 gene

Entrez Gene cytogenetic band: 6p24.1 Ensembl cytogenetic band: 6p24.1 HGNC cytogenetic band: 6p24.1

EDN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P012398: (about GC identifiers)

Start:	12,398,515 bp from pter
End:	12,405,413 bp from pter
Size:	6,899 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000006.10 NT_007592.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: EDN1_HUMAN, P05305 (See protein sequence)

Recommended Name: Endothelin-1 precursor

Size: 212 amino acids; 24425 Da

Subcellular location: Secreted

PDB structures from and Proteopedia :

1EDN (3D)

1EDP (3D)

1T7H (3D)

1V6R (3D)

Secondary accessions: Q96DA1

REFSEQ proteins: NP_001946.3

ENSEMBL proteins:

ENSP00000368683

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for EDN1
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Endothelin 1, pan Endothelin)
	Human Recombinant Proteins from Abnova (EDN1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005615	extracellular space	IEA	--
GO:0005737	cytoplasm	IDA	12379507

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Antibodies for EDN1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of EDN1
	Sigma-Aldrich Antibody Arrays and Antibodies for EDN1
	R&D Systems Antibodies for EDN1 (Endothelin-1)
	Antibodies from Abcam (Endothelin 1, pan Endothelin), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (EDN1)
	Novus Biologicals Antibodies for EDN1

Assays for EDN1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	R&D Systems ELISAs for EDN1 (Endothelin-1) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P05305

ProtoNet protein and cluster: P05305

1 Blocks protein family: IPB003641 Endothelin

UniProtKB/Swiss-Prot: EDN1_HUMAN, P05305

Similarity: Belongs to the endothelin/sarafotoxin family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (EDN1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (EDN1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001955

Applied Biosystems Silencer® siRNAs for EDN1

Sigma-Aldrich siRNA for EDN1

Sigma-Aldrich shRNA for EDN1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for EDN1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001955
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001955
untagged cDNA clones in CMV expression vector (see all 2): NM_001955

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001955

UniProtKB/Swiss-Prot: EDN1_HUMAN, P05305

Function: Endothelins are endothelium-derived vasoconstrictor peptides

Genatlas biochemistry entry for EDN1:

endothelin 1 (vaso-constrictor/pressor peptide),phospholipase C activator,interacting with I16 for

induced expression of fetal genes in cardiac myocytes

14 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Edn1):

	craniofacial	digestive/alimentary	embryogenesis	endocrine/exocrine gland
growth/size	hearing/vestibular/ear	homeostasis/metabolism	lethality-prenatal/perinatal	muscle
nervous system	no phenotypic analysis	renal/urinary system	skeleton

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005179	hormone activity	IDA	2649896 10770212
GO:0031707	endothelin A receptor binding	IEA	--
GO:0031708	endothelin B receptor binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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4 Sigma-Aldrich "Your Favorite Gene" Pathways for EDN1 (Your Favorite Gene powered by Ingenuity)

HIF1&alpha
Endothelin-1 Signaling
Hypoxia Signaling in the Cardiovascular System
Hepatic Fibrosis / Hepatic Stellate Cell Activation

GeneDecks EDN1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for EDN1

5/197 Interacting proteins for EDN1 (ENSP00000368683³ P05305²) via UniProtKB, MINT, and/or STRING (see all 197 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BAT3	P46379²	MINT-63406
COPS6	Q7L5N1²	MINT-63405
UBQLN4	Q9NRR5²	MINT-2858310
EDNRA	ENSP00000315011³	STRING (score=.999)
EDNRB	ENSP00000366416³	STRING (score=.999)

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5/48 Gene Ontology (GO) biological process terms (links to tree view) (see all 48 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001569	patterning of blood vessels	IEA	--
GO:0001666	response to hypoxia	IEA	--
GO:0001701	in utero embryonic development	IEA	--
GO:0003100	regulation of systemic arterial blood pressure by endothelin	IDA	2649896
GO:0006885	regulation of pH	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for EDN1 available from Tocris Bioscience

Compound	Action	CAS number
BMS 182874 hydrochloride	Highly selective, orally active non-peptide ETA antagonist	[153042-42-3]
BQ 788 sodium salt	Selective ETB antagonist	[156161-89-6]
IRL-1620	Highly selective ETB agonist	[142569-99-1]
FR 139317	Highly potent, selective ETA antagonist	[142375-60-8]
BQ-123	Selective ETA antagonist	[136553-81-6]

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10/38 Novoseek chemical compound relationships for EDN1 gene (see all 38 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
sarafotoxin	91.38	235	7889304 (8), 8287917 (3), 8587426 (3), 12193054 (3) (see all 99)
nitric oxide	80.57	1983	14526432 (11), 14695117 (8), 18001528 (8), 17361520 (8) (see all 99)
fr139317	80.31	34	9831924 (3), 9595416 (2), 9846633 (2), 9440503 (2) (see all 21)
bq 3020	79.07	8	15075338 (3), 10822048 (2), 7647976 (1), 7679333 (1) (see all 5)
bq610	77.55	11	10218898 (1), 7796447 (1), 8631621 (1), 10445306 (1) (see all 9)
sitaxsentan	76.00	3	17314684 (1), 10869264 (1), 16292989 (1)
pd 151242	75.79	1	8012722 (1)
irl 1620	75.17	18	8575510 (4), 15280069 (3), 9272381 (2), 10705994 (1) (see all 10)
pd 142893	73.57	7	9272381 (2), 12147606 (1), 7616437 (1), 8664342 (1) (see all 6)
bq 485	70.59	7	9870082 (2), 9806262 (1), 8916955 (1), 11476755 (1)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (EDN1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (EDN1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001955

Sigma-Aldrich siRNA for EDN1

Sigma-Aldrich shRNA for EDN1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001955

REFSEQ mRNAs for EDN1 gene:

NM_001955.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001955

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001955
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001955
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001955

Additional cDNA sequence: BC036851.1

5 DOTS entries:

DT.215144 DT.99934348 DT.91949623 DT.100777041 DT.121310909

24/143 AceView cDNA sequences (see all 143 ):

BM680754 BQ015938 T27748 AA937140 CA307702 R07349 BQ009676 CR591383

BU728406 CA306604 AA302119 BQ185104 CB105582 BF590429 BG054871 CA426258

CB105976 CA307269 CA309734 AI126868 F02908 AW043551 BM671893 CB105477

highest scoring ESTs for EDN1:

AA302119 AA302475 AA603817 AA716281 AA926633 AI002660 AI039852 AI094124 AI095619 AI126868

Unigene Clusters for EDN1:

Endothelin 1

Hs.511899 [show with all ESTs], Hs.713645 [show with all ESTs]

Unigene Representative Sequences: NM_001955, BC036851

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for EDN1

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4a	·	4b	^	5
SP1:							-
SP2:							-
SP3:

About this scheme

ECgene alternative splicing isoforms for EDN1

1 Ensembl transcript including schematic representation:

ENST00000379375

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

EDN1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for EDN1

¹ / ² / ³

5 probe-sets matching EDN1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
222802_at²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
218995_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001955	0.60	1.00	0.82	1
222802_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
218995_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1564630_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TAAAATTAGA

SOURCE GeneReport for Unigene clusters: Hs.511899 Hs.713645
UniProtKB/Swiss-Prot: EDN1_HUMAN, P05305
Tissue specificity: Expressed in lung, placental stem villi vessels and in cultured placental
vascular smooth muscle cells

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for EDN1 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	EDN1¹	--	endothelin 1	83.25(n) 74.13(a)	403424 NM_001002956.1 NP_001002956.1
chimpanzee (Pan troglodytes)	EDN1¹	--	endothelin 1	98.43(n) 96.23(a)	462437 XM_518241.2 XP_518241.2
cow (Bos taurus)	EDN1¹	--	endothelin 1	83.08(n) 74.13(a)	281137 NM_181010.2 NP_851353.1
rat (Rattus norvegicus)	Edn1¹	--	endothelin 1	79.6(n) 72.14(a)	24323 NM_012548.1 NP_036680.1
mouse (Mus musculus)	Edn1^{1, 5}	13 (26.00 cM)⁵	endothelin 1^{1, 5}	78.77(n)¹ 73.63(a)¹	13614¹ NM_010104.2¹ NP_034234.1¹ AB081657⁵ AK040778⁵ (see all 17)

About this table Species with no ortholog for EDN1

ENSEMBL Gene Tree for EDN1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for EDN1 gene

EDN2² EDN3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/100 NCBI SNPs in EDN1 are shown (see all 100 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 73)

AB	SNP ID	Valid	Chr 6 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs9296344^1,2	A,C,F,H	12405014(+)	`TAATAT/CTTTCA`	1	--	ut3¹		19	NS EU EA WA	1908
	rs4714384^1,2	A,C,F,H	12405839(+)	`AGTTAC/TATACC`	1	--	ng3¹		18	NS EA NA EU WA	1460
	rs4714383^1,2	A,C,F,H	12405468(+)	`AAGTAT/CCATAA`	1	--	ng3¹		15	NS EU EA WA	1494
	rs3087459^1,2	A,C,F,H	12397625(+)	`AGGCAA/CCATTC`	1	--	ng5¹		15	NA EA NS EU WA	2811
	rs5370^1,2	A,C,F,H	12404241(+)	`GGCAAG/TCCCTC`	1	K/N	mis¹ ese³		24	MN EA CSAM NS EU WA NA	3908
	rs10478732^1,2	C,F,H	12405759(+)	`GTGAGA/GGATGC`	1	--	ng3¹		11	NS EU EA WA	1072
	rs6413478^1,2	C,F,H	12404203(+)	`ACAGCG/ATCAAA`	1	I/V	mis¹ ese³		9	MN CSAM EA EU WA	820
	rs3756863^1,2	A,C,F	12397016(-)	`CTTTTT/CTCCCT`	1	--	ng5¹ trp³		1	NS	150
--	rs1800785^1,2	A,C,F	12397179(+)	`CCATAG/AGTCTT`	1	--	ng5¹		7	NS	642
	rs1800541^1,2	C,F,O	12397205(+)	`GCGCTT/GTGGTG`	1	--	ng5¹		10	NA EA NS	1740

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HapMap Linkage Disequilibrium images for EDN1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 131240

10/97 Novoseek disease relationships for EDN1 gene (see all 97 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
hypertension pulmonary	78.62	331	8594905 (6), 16864942 (4), 10625089 (4), 8497283 (4) (see all 99)
vasospasm	72.95	93	9254095 (6), 12910400 (4), 11053063 (3), 14623768 (3) (see all 55)
essential hypertension	67.00	146	9283062 (6), 10522417 (4), 12425201 (3), 7986462 (3) (see all 70)
atherosclerosis	66.74	226	11755940 (4), 9647335 (4), 15320823 (4), 18673159 (4) (see all 99)
hypertension arterial	65.66	54	11675821 (3), 12628956 (2), 18925520 (2), 9270291 (1) (see all 38)
heart failure	65.43	284	8176102 (6), 9861298 (5), 16076689 (5), 8606275 (4) (see all 99)
pulmonary hypertension secondary	63.63	13	10194659 (2), 18211765 (1), 8594905 (1), 10444023 (1) (see all 11)
cardiovascular diseases	62.36	102	17617392 (2), 19057845 (2), 11078363 (2), 8981573 (1) (see all 71)
cerebral vasospasm	60.98	46	10713190 (4), 11340231 (3), 10763512 (3), 15104415 (2) (see all 26)
preeclampsia	60.26	224	11167202 (5), 12193142 (5), 8372594 (5), 17261879 (5) (see all 80)

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Human Gene Mutation Database: EDN1
Genetic Association Database: EDN1
Human Genome Epidemiology Navigator: EDN1 (89 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

Additional Genetic Mutations Found in SIDS Babies: Focus is on the Autonomic Nervous System

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/2953 PubMed articles for EDN1 gene (see all 2953 ):

Evaluation of the Lys198Asn and -134delA genetic polymorphisms of the endothelin-1 gene. (PubMed id 15198485)^{1, 3, 6} Tanaka C....Miyata T. (2004)
[Correlation between polymorphism of TaqI of ET-1 gene and cirrhotic portal hypertension] (PubMed id 12887757)^{1, 3, 6} Lin J.S....Xiong P. (2003)
Genes encoding endothelin-converting enzyme-1 and endothelin-1 interact to influence blood pressure in women: the EVA study. (PubMed id 15126915)^{1, 3, 6} Funalot B....Ducimetiere P. (2004)
Association between glaucoma and gene polymorphism of endothelin type A receptor. (PubMed id 15988412)^{1, 3, 6} Ishikawa K....Mashima Y. (2005)
The double heterozygote of two endothelin-1 gene polymorphisms (G8002A and -3A/-4A) is related to big endothelin levels in chronic heart failure. (PubMed id 12565798)^{1, 3, 6} Vasku A....Vacha J. (2002)
Association between the endothelin-1 gene Lys198Asn polymorphism blood pressure and plasma endothelin-1 levels in normal and pre-eclamptic pregnancy. (PubMed id 11593097)^{1, 3, 6} Barden A.E....Van Bockxmeer F.M. (2001)
Gender-specific association between preproendothelin-1 genotype and reduction of systolic blood pressure during antihypertensive treatment--results from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation versus Atenolol (SILVHIA). (PubMed id 15188945)^{1, 3, 6} Hallberg P....Melhus H. (2004)
[Relationship of endothelin-1 (ET-1) TaqI and tumor necrosis factor (TNF) a gene polymorphism with portal hypertension in liver cirrhosis.] (PubMed id 15623376)^{1, 3, 6} Cheng Y.Q....Xiong P. (2004)
Endothelin-1 gene and progression of blood pressure and left ventricular mass: longitudinal findings in youth. (PubMed id 15505112)^{1, 3, 6} Dong Y....Snieder H. (2004)
Endothelin-1 gene polymorphism in patients with malignant arrhythmias. (PubMed id 15838369)^{1, 3, 6} Kozak M....Vacha J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 1906	HGNC: 3176	AceView: EDN1	Ensembl:ENSG00000078401	euGenes: HUgn1906
ECgene: EDN1	H-InvDB: EDN1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
NIEHS-SNPs	http://egp.gs.washington.edu/data/edn1/
R&D Systems' cytokine source book: Endothelin-1	http://www.rndsystems.com/molecule_detail.aspx?m=1364
Wikipedia	http://en.wikipedia.org/wiki/Endothelin

Licensable Technologies for EDN1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for EDN1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for EDN1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for EDN1		Antibodies for EDN1
	Explore super-pooled esiRNAs		Proteins for EDN1
	Lentivirus-delivered shRNAs for EDN1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (EDN1)
	Antibodies (EDN1)
	Chimera RNAi (EDN1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (Endothelin 1, pan Endothelin)
	Antibodies (Endothelin 1, pan Endothelin)

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Antibodies for EDN1

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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EDN1 Gene at Home site.
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EDN1 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for EDN1

Summaries
for EDN1

Genomic Location
for EDN1

Proteins
for EDN1

Protein Domains/
Families
for EDN1

Gene Function
for EDN1

Pathways & Interactions
for EDN1

Drugs & Compounds
for EDN1

Transcripts
for EDN1

Expression
for EDN1

Orthologs
for EDN1

Paralogs
for EDN1

SNPs/Variants
for EDN1

Disorders & Mutations
for EDN1

Medical News
for EDN1

Publications
for EDN1

Search for EDN1

Genome Databases showing EDN1

Other Databases showing EDN1

Specialized Databases showing EDN1

Licensable Technologies
for EDN1

Services
for EDN1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

EDN1 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor EDN1

Summariesfor EDN1

Genomic Locationfor EDN1

Proteinsfor EDN1

Protein Domains/Familiesfor EDN1

Gene Functionfor EDN1

Pathways & Interactionsfor EDN1

Drugs & Compoundsfor EDN1

Transcriptsfor EDN1

Expression for EDN1

Orthologsfor EDN1

Paralogsfor EDN1

SNPs/Variantsfor EDN1

Disorders & Mutationsfor EDN1

Medical Newsfor EDN1

Publicationsfor EDN1

Search for EDN1

Genome Databases showing EDN1

Other Databases showing EDN1

Specialized Databases showing EDN1

Licensable Technologiesfor EDN1

Servicesfor EDN1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for EDN1

Summaries
for EDN1

Genomic Location
for EDN1

Proteins
for EDN1

Protein Domains/
Families
for EDN1

Gene Function
for EDN1

Pathways & Interactions
for EDN1

Drugs & Compounds
for EDN1

Transcripts
for EDN1

Expression
for EDN1

Orthologs
for EDN1

Paralogs
for EDN1

SNPs/Variants
for EDN1

Disorders & Mutations
for EDN1

Medical News
for EDN1

Publications
for EDN1

Licensable Technologies
for EDN1

Services
for EDN1