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Aliases for EDIL3 Gene

Aliases for EDIL3 Gene

  • EGF-Like Repeats And Discoidin I-Like Domains 3 2 3
  • Developmentally-Regulated Endothelial Cell Locus 1 Protein 3 4
  • Integrin-Binding Protein DEL1 3 4
  • DEL1 3 4
  • EGF-Like Repeat And Discoidin I-Like Domain-Containing Protein 3 3
  • Developmental Endothelial Locus-1 3

External Ids for EDIL3 Gene

Summaries for EDIL3 Gene

Entrez Gene Summary for EDIL3 Gene

  • The protein encoded by this gene is an integrin ligand. It plays an important role in mediating angiogenesis and may be important in vessel wall remodeling and development. It also influences endothelial cell behavior. [provided by RefSeq, Jul 2008]

GeneCards Summary for EDIL3 Gene

EDIL3 (EGF-Like Repeats And Discoidin I-Like Domains 3) is a Protein Coding gene. Among its related pathways are Integrins in angiogenesis. GO annotations related to this gene include calcium ion binding and integrin binding. An important paralog of this gene is NRP2.

UniProtKB/Swiss-Prot for EDIL3 Gene

  • Promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3 integrin receptor. Inhibits formation of vascular-like structures. May be involved in regulation of vascular morphogenesis of remodeling in embryonic development

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EDIL3 Gene

Genomics for EDIL3 Gene

Genomic Location for EDIL3 Gene

Start:
83,940,554 bp from pter
End:
84,384,867 bp from pter
Size:
444,314 bases
Orientation:
Minus strand

Genomic View for EDIL3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EDIL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EDIL3 Gene

Regulatory Elements for EDIL3 Gene

Proteins for EDIL3 Gene

  • Protein details for EDIL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43854-EDIL3_HUMAN
    Recommended name:
    EGF-like repeat and discoidin I-like domain-containing protein 3
    Protein Accession:
    O43854
    Secondary Accessions:
    • B2R763
    • O43855
    • Q5D094
    • Q8N610

    Protein attributes for EDIL3 Gene

    Size:
    480 amino acids
    Molecular mass:
    53765 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for EDIL3 Gene

    Alternative splice isoforms for EDIL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EDIL3 Gene

Proteomics data for EDIL3 Gene at MOPED

Post-translational modifications for EDIL3 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys244
  • Glycosylation at Thr73, Thr88, Asn140, and Thr336

Other Protein References for EDIL3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EDIL3 Gene

Domains for EDIL3 Gene

UniProtKB/Swiss-Prot:

EDIL3_HUMAN
Domain:
  • EGF2 and EGF3 form a rigid rod via an interdomain calcium ion binding site, while the long linker between EGF1 and EGF2 lends considerable flexibility to EGF1:
    • O43854
  • Contains 3 EGF-like domains.:
    • O43854
  • Contains 2 F5/8 type C domains.:
    • O43854
genes like me logo Genes that share domains with EDIL3: view

No data available for Gene Families for EDIL3 Gene

Function for EDIL3 Gene

Molecular function for EDIL3 Gene

GENATLAS Biochemistry: EGF-like repeats and discoidin I-like domains 3,homolog to mouse Del1,initially expressed in the endothelial progenitor and in embryonic mesenchymal cells,promoting the adhesion of endothelial cells through interaction with the AVB3 integrin receptor,putative regulator of vascular morphogenesis or remodeling in embryonic development
UniProtKB/Swiss-Prot Function: Promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3 integrin receptor. Inhibits formation of vascular-like structures. May be involved in regulation of vascular morphogenesis of remodeling in embryonic development

Gene Ontology (GO) - Molecular Function for EDIL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005178 integrin binding IEA --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with EDIL3: view
genes like me logo Genes that share phenotypes with EDIL3: view

miRNA for EDIL3 Gene

miRTarBase miRNAs that target EDIL3

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for EDIL3 Gene

Localization for EDIL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EDIL3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EDIL3 Gene COMPARTMENTS Subcellular localization image for EDIL3 gene
Compartment Confidence
extracellular 5
plasma membrane 2
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for EDIL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031982 vesicle IDA 24769233
GO:0070062 extracellular exosome IDA 21362503
genes like me logo Genes that share ontologies with EDIL3: view

Pathways for EDIL3 Gene

SuperPathways for EDIL3 Gene

Superpath Contained pathways
1 Integrins in angiogenesis
genes like me logo Genes that share pathways with EDIL3: view

Pathways by source for EDIL3 Gene

1 BioSystems pathway for EDIL3 Gene

Gene Ontology (GO) - Biological Process for EDIL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007275 multicellular organismal development IEA --
GO:0010811 positive regulation of cell-substrate adhesion IEA --
genes like me logo Genes that share ontologies with EDIL3: view

Transcripts for EDIL3 Gene

Unigene Clusters for EDIL3 Gene

EGF-like repeats and discoidin I-like domains 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EDIL3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1:
SP2: -

Relevant External Links for EDIL3 Gene

GeneLoc Exon Structure for
EDIL3
ECgene alternative splicing isoforms for
EDIL3

Expression for EDIL3 Gene

mRNA expression in normal human tissues for EDIL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EDIL3 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (7.8) and Brain - Substantia nigra (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EDIL3 Gene

SOURCE GeneReport for Unigene cluster for EDIL3 Gene Hs.482730

genes like me logo Genes that share expressions with EDIL3: view

Orthologs for EDIL3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for EDIL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EDIL3 36
  • 99.58 (n)
  • 99.79 (a)
EDIL3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EDIL3 36
  • 92.57 (n)
  • 96.87 (a)
EDIL3 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EDIL3 36
  • 92.08 (n)
  • 96.87 (a)
EDIL3 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Edil3 36
  • 89.79 (n)
  • 95.62 (a)
Edil3 16
Edil3 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EDIL3 37
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EDIL3 37
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Edil3 36
  • 89.07 (n)
  • 96.24 (a)
chicken
(Gallus gallus)
Aves EDIL3 36
  • 82.01 (n)
  • 90 (a)
EDIL3 37
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EDIL3 37
  • 92 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.7387 36
tropical clawed frog
(Silurana tropicalis)
Amphibia edil3 36
  • 78.96 (n)
  • 88.07 (a)
MGC75581 36
zebrafish
(Danio rerio)
Actinopterygii edil3 36
  • 78.37 (n)
  • 89.42 (a)
edil3 37
  • 90 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2640 37
  • 29 (a)
OneToMany
Species with no ortholog for EDIL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EDIL3 Gene

ENSEMBL:
Gene Tree for EDIL3 (if available)
TreeFam:
Gene Tree for EDIL3 (if available)

Paralogs for EDIL3 Gene

Paralogs for EDIL3 Gene

Selected SIMAP similar genes for EDIL3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with EDIL3: view

Variants for EDIL3 Gene

Sequence variations from dbSNP and Humsavar for EDIL3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs32590 -- 84,157,511(+) TATTT(A/G)CCTAT intron-variant
rs32591 -- 84,157,550(+) TTATT(A/G)TCTCA intron-variant
rs32598 -- 84,147,314(+) TCTAT(A/G)GCTAA intron-variant
rs32601 -- 84,084,347(+) GAGAG(A/T)ACATC intron-variant
rs32602 -- 84,033,645(+) gttgc(A/G)gtgag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EDIL3 Gene

Variant ID Type Subtype PubMed ID
nsv823108 CNV Loss 20364138
nsv4905 CNV Insertion 18451855
nsv525596 CNV Loss 19592680
nsv830368 CNV Loss 17160897
esv2676239 CNV Deletion 23128226
dgv200n6 CNV Loss 16902084
esv2658431 CNV Deletion 23128226
nsv520830 CNV Gain 19592680
nsv329064 CNV Loss 16902084
nsv830369 CNV Loss 17160897
esv2120037 CNV Deletion 18987734
esv2730404 CNV Deletion 23290073
nsv882249 CNV Loss 21882294
nsv830371 CNV Gain 17160897
esv2661836 CNV Deletion 23128226
esv2730405 CNV Deletion 23290073
esv2657400 CNV Deletion 23128226

Relevant External Links for EDIL3 Gene

HapMap Linkage Disequilibrium report
EDIL3
Human Gene Mutation Database (HGMD)
EDIL3

Disorders for EDIL3 Gene

Relevant External Links for EDIL3

Genetic Association Database (GAD)
EDIL3
Human Genome Epidemiology (HuGE) Navigator
EDIL3
genes like me logo Genes that share disorders with EDIL3: view

No data available for UniProtKB/Swiss-Prot for EDIL3 Gene

Publications for EDIL3 Gene

  1. Cloning and characterization of developmental endothelial locus-1: an embryonic endothelial cell protein that binds the alphavbeta3 integrin receptor. (PMID: 9420328) Hidai C. … Quertermous T. (Genes Dev. 1998) 2 3 4
  2. Del1 mediates VSMC adhesion, migration, and proliferation through interaction with integrin alpha(v)beta(3). (PMID: 11959660) Rezaee M. … Quertermous T. (Am. J. Physiol. Heart Circ. Physiol. 2002) 3 23
  3. The role of adhesion molecules, alpha v beta 3, alpha v beta 5 and their ligands in the tumor cell and endothelial cell adhesion. (PMID: 18090124) Niu J.X. … Lou J.N. (Eur. J. Cancer Prev. 2007) 3 23
  4. The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations. (PMID: 19578876) Johnson M.P. … Moses E.K. (Hum. Genet. 2009) 3 49
  5. Chemerin, a novel adipokine in the regulation of angiogenesis. (PMID: 20237162) Bozaoglu K. … Jowett J.B. (J. Clin. Endocrinol. Metab. 2010) 3 49

Products for EDIL3 Gene

Sources for EDIL3 Gene

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