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EDIL3 Gene

protein-coding   GIFtS: 54

GC05M083272
EGF-like repeats and discoidin I-like domains 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
DEL1 1, 2, 3
MGC26287 2
Descriptions
Developmentally-regulated endothelial cell locus 1 protein 3
EGF-like repeats and discoidin I-like domains 3 2
EGF-like repeats and discoidin I-like domains-containing
protein 3 2
Integrin-binding protein DEL1 3
developmental endothelial locus-1 2
External Ids
HGNC: 31731
Entrez Gene: 100852
UniProtKB: O438543
Ensembl: ENSG000001641767
Search outside databases for aliases for EDIL3 gene

Previous GC identifers: GC05M082056 GC05M083465 GC05M083277 GC05M083322 GC05M083320

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for EDIL3:
The protein encoded by this gene is an integrin ligand. It plays an important role in mediating
angiogenesis and may be important in vessel wall remodeling and development. It also influences
endothelial cell behavior. [provided by RefSeq]

UniProtKB/Swiss-Prot: EDIL3_HUMAN, O43854
Function: Promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3
integrin receptor. Inhibits formation of vascular-like structures. May be involved in regulation
of vascular morphogenesis of remodeling in embryonic development

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the EDIL3 gene  

Entrez Gene cytogenetic band: 5q14   Ensembl cytogenetic band:  5q14.3   HGNC cytogenetic band: 5q14

EDIL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M083272:     (about GC identifiers)

Start:
83,273,882 bp from pter
End:
83,716,367 bp from pter
Size:
442,486 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000005.8  NT_006713.14  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: EDIL3_HUMAN, O43854 (See protein sequence)
Recommended Name: EGF-like repeat and discoidin I-like domain-containing protein 3 precursor  
Size: 480 amino acids; 53765 Da
Subcellular location: Secreted
Secondary accessions: O43855
Alternative splicing: 2 isoforms:  O43854-1   O43854-2   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_005702.3  

    ENSEMBL proteins: 
    ENSP00000369483 ENSP00000296591 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (EDIL3)
    Human Recombinant Proteins from Abnova (EDIL3)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    1 Gene Ontology (GO) cellular component term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576 extracellular region IEA--
    About this table

    Antibodies for EDIL3: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (EDIL3), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (EDIL3)
    Novus Biologicals Antibodies for EDIL3

    Assays for EDIL3: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5/8 InterPro domains/families (see all 8 ):
     IPR001881 EGF_Ca_bd
     IPR000742 EGF_3
     IPR013032 EGF-like_reg_CS
     IPR000421 Coagulation_factor_5/8-type_C
     IPR006209 EGF


       GeneDecks  EDIL3 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry O43854

    ProtoNet protein and cluster: O43854

    3 Blocks protein families:
    IPB000152 Aspartic acid and asparagine hydroxylation site
    IPB000421 Coagulation factor 5/8 type C domain (FA58C)
    IPB001881 EGF-like calcium-binding


    UniProtKB/Swiss-Prot: EDIL3_HUMAN, O43854
    Similarity: Contains 3 EGF-like domains
    Similarity: Contains 2 F5/8 type C domains

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (EDIL3)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (EDIL3)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005711

                  Applied Biosystems Silencer® siRNAs for EDIL3

                  Sigma-Aldrich siRNA for EDIL3  
                         Sigma-Aldrich shRNA Panels and shRNA for EDIL3  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for EDIL3
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_005711
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_005711
                                     untagged cDNA clone in CMV expression vector: NM_005711 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_005711

    UniProtKB/Swiss-Prot: EDIL3_HUMAN, O43854
    Function: Promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3
    integrin receptor. Inhibits formation of vascular-like structures. May be involved in regulation
    of vascular morphogenesis of remodeling in embryonic development

    Genatlas biochemistry entry for EDIL3:
    EGF-like repeats and discoidin I-like domains 3,homolog to mouse Del1,initially expressed in the
    endothelial progenitor and in embryonic mesenchymal cells,promoting the adhesion of endothelial
    cells through interaction with the AVB3 integrin receptor,putative regulator of vascular
    morphogenesis or remodeling in embryonic development

    2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Edil3):

    immune systemnormal

    3 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005178 integrin binding TAS9420328
    GO:0005509 calcium ion binding IEA--
    GO:0005515 protein binding IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    5 Interacting proteins for EDIL3 (ENSP000003694833) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITGAVENSP000003640423STRING (score=.977)
    ITGB3ENSP000002620173STRING (score=.939)
    PTK2ENSP000003411893STRING (score=.934)
    FZR1ENSP000002219263STRING (score=.91)
    COL2A1ENSP000003465113STRING (score=.744)
    About this table

    2 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155 cell adhesion IEA--
    GO:0007275 multicellular organismal development IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for EDIL3

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (EDIL3)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (EDIL3)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005711

                  Sigma-Aldrich siRNA for EDIL3  
                         Sigma-Aldrich shRNA Panels and shRNA for EDIL3  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_005711  

    REFSEQ mRNAs for EDIL3 gene: 

    NM_005711.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_005711  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_005711
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_005711
                                     untagged cDNA clone in CMV expression vector: NM_005711 

    Additional cDNA sequence: 

    AK302942.1 AK312858.1 BC030828.1 BC053656.1 BX648583.1 U70312.1 U70313.1 

    6 DOTS entries:

    DT.91777446  DT.100001530  DT.97860119  DT.91637882  DT.425799  DT.100830870 

    24/174 AceView cDNA sequences (see all 174 ):

    AL119254 AA256268 CF994301 AW026173 AA376667 AA643796 AA137140 AA977716 
    AJ243962 AW296259 CB961138 BC030828 BX952210 NM_005711 BM665960 AA886718 
    AI677769 CB117681 AA256196 CD652646 CD654559 T35664 N99433 N99719 

    highest scoring ESTs for EDIL3:

    U70312 AI057101 AI352093 AL713174 BC030828 BC053656 BF507364 BG705908 BI553433 BI603549 

    Unigene Cluster for EDIL3:

    EGF-like repeats and discoidin I-like domains 3
    Hs.482730  [show with all ESTs]
    Unigene Representative Sequence: BX648583


    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for EDIL3

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                                                                        
    SP2:                    -                                                   

    About this scheme

    ECgene alternative splicing isoforms for EDIL3

    2 Ensembl transcripts including schematic representations:
    ENST00000380138  ENST00000296591  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    EDIL3 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for EDIL3

    1 / 2 / 3

    7 probe-sets matching EDIL3 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    63316_at2, 3 U95-C 1 1.00 1.00 0.98 1.48 AL047586 0.60 1.00 0.82 1
    39901_at2, 3 U95-A 1 1.00 1.00 0.96 0.54 U70312 1.00 1.00 1.00 1

    207379_at2, 3 U133-A 1 1.00 1.00 -- -- NM_005711 0.60 1.00 0.82 1

    225275_at2, 3 U133-B 1 1.00 1.00 -- -- AA053711 0.60 1.00 0.82 1

    207379_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    1558643_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    225275_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  EDIL3 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: CTAATTTTAC

    SOURCE GeneReport for Unigene cluster: Hs.482730

    Expression variation in blood from EXPOLDB for EDIL3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for EDIL3 gene from 5/8 species (see all 8 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    EDIL31   -- EGF-like repeats and discoidin I-like domains 3 92.08(n)
    96.87(a)
    488919  XM_546036.2  XP_546036.2 
    chimpanzee
    (Pan troglodytes)
    EDIL31   -- EGF-like repeats and discoidin I-like domains 3 99.58(n)
    99.79(a)
    471489  XM_001146806.1  XP_001146806.1 
    cow
    (Bos taurus)
    EDIL31   -- EGF-like repeats and discoidin I-like domains 3 93.22(n)
    98.03(a)
    538062  XM_618255.3  XP_618255.3 
    mouse
    (Mus musculus)
    Edil31, 5 135
    EGF-like repeats and discoidin I-like domains 31, 5 89.79(n)1
    95.62(a)1
    136121  NM_001037987.21  NP_001033076.11 
     AA7546825  AC1219165  (see all 21)
    chicken
    (Gallus gallus)
    EDIL31   -- EGF-like repeats and discoidin I-like domains 3 83.26(n)
    92.58(a)
    427326  XM_424906.2  XP_424906.2 
    About this table        Species with no ortholog for EDIL3

    ENSEMBL Gene Tree for EDIL3
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for EDIL3 gene
    NRP22  NRP12  MFGE82  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/2151 NCBI SNPs in EDIL3 are shown (see all 2151 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 673)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 5 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs3056611,2
    A,C,F,H83716793(-) AGTCAG/ATGCTG 1 -- ng31 tfbs35Minor allele frequency- A:0.22MN EU EA WA 604
    --
    rs92933601,2
    A,C,F,H83273992(+) TGGCCG/AAACTA 1 -- ut314Minor allele frequency- A:0.36EU EA WA 418
    rs126594691,2
    A,C,F,H83718035(+) TGAAAC/GTATGT 1 -- ng314Minor allele frequency- G:0.18EU EA WA 410
    rs3056631,2
    C,F,H83717671(-) AATTTG/CAAAAG 1 -- ng31 trp36Minor allele frequency- C:0.26EU WA EA 632
    rs125229531,2
    C,F,H83274252(+) ATACAG/AATCAA 1 -- ut31 ese38Minor allele frequency- A:0.17EU EA WA 830
    --
    rs11397501,2
    C83274137(-) CAAAAG/AAACAA 1 -- ut314Minor allele frequency- A:0.00MN NA 326
    rs119510361,2
    H83273557(+) AAATAG/CCAGTG 1 -- ng51 ese34Minor allele frequency- C:0.00EU EA WA 418
    rs126552881,2
    H83717933(+) AAGTCA/CCAGAT 1 -- ng314Minor allele frequency- C:0.00EU EA WA 412
    rs22692871,2
    C,F,H83396276(+) TTACCC/TGACAG 1 S/S syn1 ese38Minor allele frequency- T:0.13EA NA EU WA 2034
    rs3488951,2
    A,C,F,H,O83444665(+) AAATCG/ACTGCC 1 -- int111Minor allele frequency- A:0.24EU EA WA NA 874
    About this table

    HapMap Linkage Disequilibrium images for EDIL3 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 606018

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10 PubMed articles for EDIL3 gene:
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 10085 HGNC: 3173 AceView: EDIL3 Ensembl:ENSG00000164176 euGenes: HUgn10085
    ECgene: EDIL3 H-InvDB: EDIL3
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for EDIL3:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for EDIL3-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for EDIL3 Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for EDIL3 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Antibodies for EDIL3

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