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Aliases & Descriptions for EDIL3
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| DEL1 1, 2, 3 | | MGC26287 2 |
| | | Descriptions |
|---|
| Developmentally-regulated endothelial cell locus 1 protein 3 | | EGF-like repeats and discoidin I-like domains 3 2 | EGF-like repeats and discoidin I-like domains-containing protein 3 2 | | Integrin-binding protein DEL1 3 | | developmental endothelial locus-1 2 |
|
| | Search outside databases for aliases for EDIL3 genePrevious GC identifers: GC05M082056 GC05M083465 GC05M083277 GC05M083322 GC05M083320 |
Summaries for EDIL3(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for EDIL3: The protein encoded by this gene is an integrin ligand. It plays an important role in mediating angiogenesis and may be important in vessel wall remodeling and development. It also influences endothelial cell behavior. [provided by RefSeq] UniProtKB/Swiss-Prot: EDIL3_HUMAN, O43854Function: Promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3 integrin receptor. Inhibits formation of vascular-like structures. May be involved in regulation of vascular morphogenesis of remodeling in embryonic development |
Genomic Location for EDIL3
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the EDIL3 gene 
Entrez Gene cytogenetic band: 5q14 Ensembl cytogenetic band: 5q14.3 HGNC cytogenetic band: 5q14EDIL3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M083272:
(about GC identifiers)
Start:
|
83,273,882 bp from pter |
End:
|
83,716,367 bp from pter |
Size:
|
442,486 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000005.8 NT_006713.14
| Proteins for EDIL3
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: EDIL3_HUMAN, O43854 (See
protein sequence)Recommended Name: EGF-like repeat and discoidin I-like domain-containing protein 3 precursor Size: 480 amino acids; 53765 Da
Subcellular location: Secreted
Secondary accessions: O43855Alternative splicing: 2 isoforms: O43854-1 O43854-2 Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_005702.3
ENSEMBL proteins: ENSP00000369483 ENSP00000296591
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- | About this table
Antibodies for EDIL3: Assays for EDIL3: | Protein
Domains/ Families for EDIL3(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry O43854
ProtoNet protein and cluster: O43854 3 Blocks protein families: IPB000152 Aspartic acid and asparagine hydroxylation site IPB000421 Coagulation factor 5/8 type C domain (FA58C) IPB001881 EGF-like calcium-binding
UniProtKB/Swiss-Prot: EDIL3_HUMAN, O43854Similarity: Contains 3 EGF-like domainsSimilarity: Contains 2 F5/8 type C domains | Gene Function for EDIL3
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005711
Applied Biosystems Silencer® siRNAs for EDIL3
Sigma-Aldrich siRNA for EDIL3  Sigma-Aldrich shRNA Panels and shRNA for EDIL3  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005711                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005711                                  untagged cDNA clone in CMV expression vector: NM_005711 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_005711
UniProtKB/Swiss-Prot: EDIL3_HUMAN, O43854Function: Promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3 integrin receptor. Inhibits formation of vascular-like structures. May be involved in regulation of vascular morphogenesis of remodeling in embryonic developmentGenatlas biochemistry entry for EDIL3:EGF-like repeats and discoidin I-like domains 3,homolog to mouse Del1,initially expressed in the endothelial progenitor and in embryonic mesenchymal cells,promoting the adhesion of endothelial cells through interaction with the AVB3 integrin receptor,putative regulator of vascular morphogenesis or remodeling in embryonic development2 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Edil3):
3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for EDIL3
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5 Interacting proteins for EDIL3 (ENSP000003694833) via UniProtKB, MINT, and/or STRINGAbout this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007155 | cell adhesion |
IEA | -- | | GO:0007275 | multicellular organismal development |
IEA | -- | About this table
|
Drugs & Compounds for EDIL3(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for EDIL3
|
Transcripts for EDIL3(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005711
Sigma-Aldrich siRNA for EDIL3  Sigma-Aldrich shRNA Panels and shRNA for EDIL3  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_005711 REFSEQ mRNAs for EDIL3 gene: NM_005711.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005711               OriGene GFP tagged cDNA clone in CMV expression vector: NM_005711                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005711                                  untagged cDNA clone in CMV expression vector: NM_005711  Additional cDNA sequence: AK302942.1 AK312858.1 BC030828.1 BC053656.1 BX648583.1 U70312.1 U70313.1 6 DOTS entries: DT.91777446 DT.100001530 DT.97860119 DT.91637882 DT.425799 DT.100830870 24/174 AceView cDNA sequences (see all 174
):AL119254 AA256268 CF994301 AW026173 AA376667 AA643796 AA137140 AA977716 AJ243962 AW296259 CB961138 BC030828 BX952210 NM_005711 BM665960 AA886718 AI677769 CB117681 AA256196 CD652646 CD654559 T35664 N99433 N99719
highest scoring ESTs for EDIL3:U70312 AI057101 AI352093 AL713174 BC030828 BC053656 BF507364 BG705908 BI553433 BI603549 Unigene Cluster for EDIL3: EGF-like repeats and discoidin I-like domains 3 Hs.482730 [show with all ESTs]Unigene Representative Sequence: BX648583
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for EDIL3
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for EDIL3
2 Ensembl transcripts including schematic representations: ENST00000380138
ENST00000296591
|
Expression for EDIL3
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| EDIL3 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for EDIL3
1 / 2 / 3 7 probe-sets matching EDIL3 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CTAATTTTAC
SOURCE GeneReport for Unigene cluster: Hs.482730
Expression variation in blood from EXPOLDB for EDIL3 |
Orthologs for EDIL3
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for EDIL3 gene from 5/8 species (see all 8
)
About this table Species with no ortholog for EDIL3
ENSEMBL Gene Tree for EDIL3 | Paralogs for EDIL3(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for EDIL3 gene
- NRP22 NRP12 MFGE82
|
SNPs/Variants for EDIL3(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for EDIL3 (up to first 250kb)
|
Disorders & Mutations for EDIL3
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 606018
|
Medical News for EDIL3(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for EDIL3 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10 PubMed articles for EDIL3 gene:- Cloning and characterization of developmental endothelial locus-1: an embryonic endothelial cell protein that binds the alphavbeta3 integrin receptor. (PubMed id 9420328)2, 3, 4 Hidai C.... Quertermous T. (1998)
- Del1 mediates VSMC adhesion, migration, and proliferation through interaction with integrin alpha(v)beta(3). (PubMed id 11959660)1, 3 Rezaee M....Quertermous T. (2002)
- The role of adhesion molecules, alpha v beta 3, alpha v beta 5 and their ligands in the tumor cell and endothelial cell adhesion. (PubMed id 18090124)1, 3 Niu J.X....Lou J.N. (2007)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- The embryonic angiogenic factor Del1 accelerates tumor growth by enhancing vascular formation. (PubMed id 12074641)3 Aoka Y....Quertermous T. (2002)
- Developmental endothelial locus-1 (Del-1), a novel angiogenic protein: its role in ischemia. (PubMed id 14981004)1 Ho H.K....Cooke J.P. (2004)
- Del1 induces integrin signaling and angiogenesis by ligation of alphaVbeta3. (PubMed id 10196194)1 Penta K....Quertermous T. (1999)
- Expression of developmental endothelial locus-1 in a subset of macrophages for engulfment of apoptotic cells. (PubMed id 15004195)1 Hanayama R....Nagata S. (2004)
- The secreted EGF-Discoidin factor xDel1 is essential for dorsal development of the Xenopus embryo. (PubMed id 17433289)1 Arakawa A....Sasai Y. (2007)
- Robust and prolonged gene expression from injectable polymeric implants. (PubMed id 12215890)1 Eliaz R.E. and Szoka F.C. (2002)
|
Search for EDIL3
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing EDIL3
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing EDIL3
(According to HUGE)
About This Section
| -- |
Specialized Databases showing EDIL3(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for EDIL3(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for EDIL3:

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Incremental update: 13 Oct 2009
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