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S1PR5 Gene

protein-coding GIFtS: 56

GC19M010485

sphingosine-1-phosphate receptor 5
(Previous names: endothelial differentiation, sphingolipid G-protein-coupled receptor, 8 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: EDG8)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EDG8 ^², ³, ⁵
Edg-8 ^¹, ²
S1P5 ^², ³
SPPR-1 ^²
SPPR-2 ^²

Descriptions
Endothelial differentiation G-protein-coupled receptor 8 ^³
S1P receptor 5 ^³
S1P receptor Edg-8 ^³
Sphingosine 1-phosphate receptor Edg-8 ^², ³
endothelial differentiation, sphingolipid G-protein-coupled receptor, 8 ^¹, ²
sphingosine 1-phosphate receptor 5 ^²
sphingosine-1-phosphate receptor 5 ^²

External Ids
HGNC: 14299¹
Entrez Gene: 53637²
UniProtKB: Q9H228³
Ensembl: ENSG00000180739⁷

Search outside databases for aliases for S1PR5 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for S1PR5:

The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis,

motility, and neurite retraction. Its actions may be both intracellular as a second messenger and

extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator

lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG

receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P receptors; others (e.g., EDG2; MIM

602282) are LPA receptors.[supplied by OMIM]

UniProtKB/Swiss-Prot: S1PR5_HUMAN, Q9H228

Function: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive

lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is

coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May

play a regulatory role in the transformation of radial glial cells into astrocytes and may affect

proliferative activity of these cells

Gene Wiki entry for S1PR5 (EDG8)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.2

S1PR5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M010485: (about GC identifiers)

Start:	10,484,622 bp from pter
End:	10,489,127 bp from pter
Size:	4,506 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000019.8 NT_011295.10

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: S1PR5_HUMAN, Q9H228 (See protein sequence)

Recommended Name: Sphingosine 1-phosphate receptor 5

Size: 398 amino acids; 41775 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Developmental stage: At 24 weeks of gestation, fragments of radial glial fibers are positive within

the cortical plate and subplate of allocortical areas. These positive fragments often appear

enlarged as varicosities and some of them terminate at blood vessels. Between 28 and 30 weeks of

gestation, all iso- and allocortical areas contain immunolabelled radial glial fibers revealing

curvature next to sulci. After 32 weeks of gestation, radial glial fibers gradually disappear;

instead positive transitional stages between radial glia and astrocytes were found

Secondary accessions: Q6NW11

Alternative splicing: 2 isoforms: Q9H228-1 Q9H228-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_110387.1

ENSEMBL proteins:

ENSP00000352045 ENSP00000328472

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (EDG8)
	Human Recombinant Proteins from Abnova (S1PR5)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

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Antibodies for S1PR5:

	Invitrogen Antibodies for S1PR5
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for S1PR5
	R&D Systems Antibodies for S1PR5 (EDG-8)
	Antibodies from Abcam (EDG8), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (S1PR5)
	Search Novus for antibodies for S1PR5

Assays for S1PR5:

	Browse Invitrogen for biochemical assays
	Millipore Kits and Assays for the Analysis of S1PR5
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9H228

ProtoNet protein and cluster: Q9H228

2 Blocks protein families:

IPB004061 Sphingosine 1-phosphate receptor family signature

IPB005386 EDG-8 sphingosine 1-phosphate receptor signature

UniProtKB/Swiss-Prot: S1PR5_HUMAN, Q9H228

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (S1PR5)
		Millipore RNAi Products for the Analysis of S1PR5 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (S1PR5)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_030760

Applied Biosystems Silencer® siRNAs for S1PR5

Sigma-Aldrich siRNA and siRNA Panels for S1PR5

Sigma-Aldrich shRNA Panels and shRNA for S1PR5

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for S1PR5
		Millipore Clones for the Expression of S1PR5

OriGene GFP tagged cDNA clone in CMV expression vector: NM_030760
Myc/DDK tagged cDNA clone in CMV expression vector: NM_030760
untagged cDNA clone in CMV expression vector: NM_030760

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: BC034703

UniProtKB/Swiss-Prot: S1PR5_HUMAN, Q9H228

Function: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive

lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is

coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May

play a regulatory role in the transformation of radial glial cells into astrocytes and may affect

proliferative activity of these cells

1 MGI mutant phenotype (inferred from 1 allele) (MGI details for S1pr5):

nervous system

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001619	lysosphingolipid and lysophosphatidic acid receptor activity	IEA	--
GO:0004872	receptor activity	IEA	--
GO:0004930	G-protein coupled receptor activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for S1PR5 (Your Favorite Gene powered by Ingenuity)

Ceramide Signaling
Human Embryonic Stem Cell Pluripotency

GeneDecks S1PR5 for the pathways selected above

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5/16 Interacting proteins for S1PR5 (ENSP00000328472³) via UniProtKB, MINT, and/or STRING (see all 16 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MBTPS1	ENSP00000344223³	STRING (score=.986)
GNA12	ENSP00000275364³	STRING (score=.96)
GNAO1	ENSP00000262493³	STRING (score=.96)
GNAI2	ENSP00000312999³	STRING (score=.901)
GNAI3	ENSP00000358867³	STRING (score=.901)

About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	IEA	--
GO:0007186	G-protein coupled receptor protein signaling pathway	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for S1PR5:

Mixed Agonist/Antagonist Antagonist

Compounds for S1PR5 available from Tocris Bioscience

Compound	Action	CAS number
Sphingosine-1-phosphate	Endogenous agonist at S1P1-5	[26993-30-6]

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1 Novoseek chemical compound relationship for S1PR5 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
sphingosine	75.81	7	19211033 (2)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (S1PR5)
		Millipore RNAi Products for the Analysis of S1PR5 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (S1PR5)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_030760

Sigma-Aldrich siRNA and siRNA Panels for S1PR5

Sigma-Aldrich shRNA Panels and shRNA for S1PR5

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_030760

REFSEQ mRNAs for S1PR5 gene:

NM_030760.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_030760

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_030760
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_030760
                                 untagged cDNA clone in CMV expression vector: NM_030760

Additional cDNA sequence:

AF088014.1 AF331840.1 AF331841.1 AF331842.1 AK074661.1 AK094880.1 BC034703.1 BC067781.1

CR619597.1

7 DOTS entries:

DT.101968559 DT.405571 DT.97839596 DT.100022816 DT.97839597 DT.121453900 DT.100728241

24/49 AceView cDNA sequences (see all 49 ):

BE646254 AF331841 BX282038 NM_030760 BF446252 CR619597 BX349015 AF331842

AF088014 CB049904 AI420856 CA432481 N63601 AI439969 AK094880 BX391791

AI814092 BX339823 N47089 AI823789 AK074661 BU620561 BX339822 AF331840

Unigene Cluster for S1PR5:

Sphingosine-1-phosphate receptor 5

Hs.501561 [show with all ESTs]

Unigene Representative Sequence: AF331840

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for S1PR5

ExUns:	1	^	2a	·	2b	·	2c	^	3a	·	3b	·	3c
SP1:			-		-		-
SP2:							-
SP3:

About this scheme

ECgene alternative splicing isoforms for S1PR5

2 Ensembl transcripts including schematic representations:

ENST00000359134 ENST00000333430

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

S1PR5 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for S1PR5

¹ / ²

7 probe-sets matching S1PR5 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
53620_at²	U95-B	1	1.00	1.00	1.00	1.00	--	--	--	--	--
233743_x_at²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
221417_x_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
230464_at²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
233743_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
221417_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
230464_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks S1PR5 for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GGAGGTTGAA

SOURCE GeneReport for Unigene cluster: Hs.501561
UniProtKB/Swiss-Prot: S1PR5_HUMAN, Q9H228
Tissue specificity: Widely expressed in the brain, most prominently in the corpus callosum, which
is predominantly white matter. Detected in spleen, peripheral blood leukocytes, placenta, lung,
aorta, and fetal spleen. Low-level signal detected in many tissue extracts. Isoform 1 is
predominently expressed in peripheral tissues, whereas isoform 2 is expressed in brain, spleen and
peripheral blood leukocytes

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for S1PR5 gene from 4 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	S1PR5¹	--	sphingosine-1-phosphate receptor 5	85.68(n) 85.68(a)	610828 XM_849001.1 XP_854094.1
cow (Bos taurus)	S1PR5¹	--	sphingosine-1-phosphate receptor 5	84.84(n) 85.18(a)	517533 XM_595705.3 XP_595705.3
rat (Rattus norvegicus)	S1pr5¹	--	sphingosine-1-phosphate receptor 5	78.76(n) 86.04(a)	60399 NM_021775.2 NP_068543.2
mouse (Mus musculus)	S1pr5^{1, 5}	9⁵	sphingosine-1-phosphate receptor 5^{1, 5}	79.85(n)¹ 86.99(a)¹	94226¹ NM_053190.1¹ NP_444420.1¹ AF327535⁵ AI848371⁵ (see all 9)

About this table Species with no ortholog for S1PR5

ENSEMBL Gene Tree for S1PR5

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for S1PR5 gene

S1PR3² S1PR1² S1PR2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/38 NCBI SNPs in S1PR5 are shown (see all 38 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 18)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs12460981^1,2	A,C,F,H	10489548(+)	`CGATGA/GTTCGG`	1	--	ng3¹		12		EU EA WA NA	1198
	rs12463093^1,2	A,C,F,H	10489468(+)	`GGTGTC/GCGGGC`	1	--	ng3¹		4		EU EA WA	404
	rs34924007^1,2	F	10490460(+)	`ATAAGT/CGTGGA`	1	--	ng3¹		4		NA EA	362
	rs35483143^1,2	F	10485735(+)	`GGCGCA/TGGAGC`	1	L/Q	mis¹		1		NA	22
	rs6511701^1,2	A,C,F	10486067(+)	`CAGATC/AGCGGC`	1	A/A	syn¹		3		EA NA	238
--	rs10402752^1,2	A,C,F,H	10487769(+)	`AAAAAT/CACATC`	1	--	int¹		3		EU EA	300
	rs10416073^1,2	A,C,F,H	10486796(+)	`TACCCC/ACTGAC`	1	--	int¹		4		EU EA WA	420
--	rs10418435^1,2	C	10489041(+)	`AGCCCA/CGCGCC`	1	--	int¹		0	--	--	--	--
--	rs7256518^1,2	C	10487375(+)	`gaggcA/Gggagg`	1	--	int¹		0	--	--	--	--
--	rs59129855^1,2	--	10490405(+)	`TGCTGC/GCCGCG`	1	--	ng3¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for S1PR5 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 605146

UniProtKB/Swiss-Prot: S1PR5_HUMAN, Q9H228

Overexpressed in leukemic large granular lymphocyte (LGL). LGL is a lymphopropliferative

disorder often associated with autoimmune disease

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/22 PubMed articles for S1PR5 gene (see all 22 ):

Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8): structure-activity relationship of sphingosine1-phosphate receptors. (PubMed id 11705398)^{1, 3, 4} Im D.-S.... Lynch K.R. (2001)
Evidence for the presence of the sphingosine-1-phosphate receptor Edg-8 in human radial glial fibers. (PubMed id 15530552)^{1, 3, 4} Ulfig N. and Briese M. (2004)
Characterization of a human sphingosine-1-phosphate receptor gene (S1P5) and its differential expression in LGL leukemia. (PubMed id 12427546)^{1, 3, 4} Kothapalli R.... Loughran T.P. Jr. (2002)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)^{3, 4} Grimwood J.... Lucas S.M. (2004)
Identification of G protein-coupled receptor genes from the human genome sequence. (PubMed id 12044878)^{3, 4} Takeda S.... Mitaku S. (2002)
Comparative analysis of human and rat S1P(5) (edg8): differential expression profiles and sensitivities to antagonists. (PubMed id 12234605)^{3, 4} Niedernberg A.... Kostenis E. (2002)
Characterization of a novel sphingosine 1-phosphate receptor, Edg-8. (PubMed id 10799507)^{2, 3} Im D.S....Lynch K.R. (2000)
The sphingosine 1-phosphate receptor 5 and sphingosine kinases 1 and 2 are localised in centrosomes: possible role in regulating cell division. (PubMed id 19211033)^{1, 3} Gillies L....Pyne S. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 53637	HGNC: 14299	AceView: EDG8	Ensembl:ENSG00000180739	euGenes: HUgn53637
ECgene: S1PR5	H-InvDB: S1PR5

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for S1PR5
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for S1PR5:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for S1PR5-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for S1PR5		Antibodies for S1PR5
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for S1PR5		Small molecules for S1PR5
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (S1PR5)
	Antibodies (S1PR5)
	Chimera RNAi (S1PR5)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (EDG8)
	Antibodies (EDG8)

Search OriGene for S1PR5

Tocris compounds for S1PR5

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for S1PR5

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S1PR5 Gene at Home site.
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S1PR5 Gene

protein-coding GIFtS: 56

Aliases &
Descriptions
for S1PR5

Summaries
for S1PR5

Genomic Location
for S1PR5

Proteins
for S1PR5

Protein Domains/
Families
for S1PR5

Gene Function
for S1PR5

Pathways & Interactions
for S1PR5

Drugs & Compounds
for S1PR5

Transcripts
for S1PR5

Expression
for S1PR5

Orthologs
for S1PR5

Paralogs
for S1PR5

SNPs/Variants
for S1PR5

Disorders & Mutations
for S1PR5

Medical News
for S1PR5

Publications
for S1PR5

Search for S1PR5

Genome Databases showing S1PR5

Other Databases showing S1PR5

Specialized Databases showing S1PR5

Licensable Technologies
for S1PR5

Services
for S1PR5

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

S1PR5 Gene

protein-coding GIFtS: 56

Aliases & Descriptionsfor S1PR5

Summariesfor S1PR5

Genomic Locationfor S1PR5

Proteinsfor S1PR5

Protein Domains/Familiesfor S1PR5

Gene Functionfor S1PR5

Pathways & Interactionsfor S1PR5

Drugs & Compoundsfor S1PR5

Transcriptsfor S1PR5

Expression for S1PR5

Orthologsfor S1PR5

Paralogsfor S1PR5

SNPs/Variantsfor S1PR5

Disorders & Mutationsfor S1PR5

Medical Newsfor S1PR5

Publicationsfor S1PR5

Search for S1PR5

Genome Databases showing S1PR5

Other Databases showing S1PR5

Specialized Databases showing S1PR5

Licensable Technologiesfor S1PR5

Servicesfor S1PR5

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for S1PR5

Summaries
for S1PR5

Genomic Location
for S1PR5

Proteins
for S1PR5

Protein Domains/
Families
for S1PR5

Gene Function
for S1PR5

Pathways & Interactions
for S1PR5

Drugs & Compounds
for S1PR5

Transcripts
for S1PR5

Expression
for S1PR5

Orthologs
for S1PR5

Paralogs
for S1PR5

SNPs/Variants
for S1PR5

Disorders & Mutations
for S1PR5

Medical News
for S1PR5

Publications
for S1PR5

Licensable Technologies
for S1PR5

Services
for S1PR5