LPAR3 Gene
protein-coding GIFtS: 49
GC01M085048
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lysophosphatidic acid receptor 3 (Previous names: endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 7 ) Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database (Previous symbol: EDG7)
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Aliases & Descriptions for LPAR3
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
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| Aliases |
|---|
| EDG7 2, 3, 5 | | Edg-7 1, 2 | | FLJ98231 2 | | GPCR 2 | | HOFNH30 1, 2 | | LP-A3 1, 2 | | LPA-3 3 | | LPA3 1, 2, 3, 5 | | OTTHUMP00000011573 2 | | RP4-678I3 1, 2 |
| | | Descriptions |
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| LPA receptor 3 3 | | LPA receptor EDG7 2 | | Lysophosphatidic acid receptor Edg-7 3 | | calcium-mobilizing lysophosphatidic acid receptor LP-A3 2 | | endothelial cell differentiation gene 7 2 | endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 7 1, 2 | | lysophosphatidic acid receptor 3 2 |
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| | Search outside databases for aliases for LPAR3 gene |
Summaries for LPAR3(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for LPAR3: This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins. [provided by RefSeq] UniProtKB/Swiss-Prot: LPAR3_HUMAN, Q9UBY5Function: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteinsGene Wiki entry for LPAR3 (EDG7) |
Genomic Location for LPAR3
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p22.3 Ensembl cytogenetic band: 1p22.3 HGNC cytogenetic band: 1p22.3LPAR3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M085048:
(about GC identifiers)
Start:
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85,052,089 bp from pter |
End:
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85,104,430 bp from pter |
Size:
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52,342 bases |
Orientation:
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minus strand |
RefSeq DNA sequence:- NC_000001.9 NT_032977.8
| Proteins for LPAR3
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: LPAR3_HUMAN, Q9UBY5 (See
protein sequence)Recommended Name: Lysophosphatidic acid receptor 3 Size: 353 amino acids; 40128 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: A0AVA3REFSEQ proteins: NP_036284.1
ENSEMBL proteins: ENSP00000359643
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for LPAR3: Assays for LPAR3: | Protein
Domains/ Families for LPAR3(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9UBY5
ProtoNet protein and cluster: Q9UBY5 2 Blocks protein families: IPB004065 Lysophosphatidic acid receptor family signature IPB005385 EDG-7 lysophosphatidic acid receptor signature
UniProtKB/Swiss-Prot: LPAR3_HUMAN, Q9UBY5Similarity: Belongs to the G-protein coupled receptor 1 family | Gene Function for LPAR3
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| Inhib. RNA: |  | Invitrogen RNAi Products for gene knock-down (LPAR3) | |  | Millipore RNAi Products for the Analysis of LPAR3 Gene knock-down | |  | Abnova Chimera RNAi Products for Gene knock-down (LPAR3) |               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_012152
Applied Biosystems Silencer® siRNAs for LPAR3
Sigma-Aldrich siRNA and siRNA Panels for LPAR3  Sigma-Aldrich shRNA Panels and shRNA for LPAR3  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_012152                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_012152                                  untagged cDNA clone in CMV expression vector: NM_012152 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_012152
UniProtKB/Swiss-Prot: LPAR3_HUMAN, Q9UBY5Function: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Lpar3):
4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for LPAR3
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
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5/29 Interacting proteins for LPAR3 (ENSP000003596433) via UniProtKB, MINT, and/or STRING (see all 29
)About this table
5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7
): About this table
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Drugs & Compounds for LPAR3(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for LPAR3 10/13 Novoseek chemical compound relationships for LPAR3 gene (see all 13
)
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| lysophospholipid |
68.18 |
1 |
10818447 (1) |
| lipid |
50.03 |
20 |
16093494 (2), 15993425 (2), 18491052 (2), 16246064 (2) (see all 12) |
| sphingosine |
47.44 |
1 |
18058948 (1) |
| tyrosine |
45.98 |
13 |
12548551 (3), 9398658 (1), 14567755 (1), 18558100 (1) (see all 9) |
| cyclic amp |
40.37 |
7 |
18224335 (1), 18606183 (1), 18155068 (1) |
| calcium |
29.62 |
19 |
10727522 (3), 16228299 (3), 9790898 (1), 18606183 (1) (see all 8) |
| phospholipid |
20.73 |
3 |
15220934 (1), 17452637 (1), 18952848 (1) |
| fatty acid |
6.68 |
2 |
10818460 (1), 10922489 (1) |
| atp |
0.00 |
1 |
18495810 (1) |
| oligonucleotide |
0.00 |
1 |
9398636 (1) |
About this table
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Transcripts for LPAR3(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
| Inhib. RNA: |  | Invitrogen RNAi Products for gene knock-down (LPAR3) | |  | Millipore RNAi Products for the Analysis of LPAR3 Gene knock-down | |  | Abnova Chimera RNAi Products for Gene knock-down (LPAR3) |               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_012152
Sigma-Aldrich siRNA and siRNA Panels for LPAR3  Sigma-Aldrich shRNA Panels and shRNA for LPAR3  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_012152 REFSEQ mRNAs for LPAR3 gene: NM_012152.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_012152               OriGene GFP tagged cDNA clone in CMV expression vector: NM_012152                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_012152                                  untagged cDNA clone in CMV expression vector: NM_012152  Additional cDNA sequence: AF127138.1 AF186380.1 AF236117.1 AK308283.1 AY322547.1 BC126268.1 BC126270.1 BC144021.1 4 DOTS entries: DT.91754582 DT.91798222 DT.91816580 DT.91926752 24/33 AceView cDNA sequences (see all 33
):BU633960 AI288165 AF186380 AW274018 AI223077 BX283404 AY322547 BM999782 BQ775090 AI432375 BG215668 AK091731 CD557613 AA446859 AF127138 AW172356 NM_012152 CD103667 CB140352 AI567144 CB147705 CF121369 BG207736 BG209342 Unigene Cluster for LPAR3: Lysophosphatidic acid receptor 3 Hs.674915 [show with all ESTs]Unigene Representative Sequence: NM_012152
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000370611
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Expression for LPAR3
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| LPAR3 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for LPAR3
1 / 2 2 probe-sets matching LPAR3 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.674915 UniProtKB/Swiss-Prot: LPAR3_HUMAN, Q9UBY5Tissue specificity: Most abundantly expressed in prostate, testes, pancreas, and heart, with moderate levels in lung and ovary. No detectable expression in brain, placenta, liver, skeletal muscle, kidney, spleen, thymus, small intestine, colon, or peripheral blood leukocytes |
Orthologs for LPAR3
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
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Orthologs for LPAR3 gene from 5/8 species (see all 8
)
About this table Species with no ortholog for LPAR3
ENSEMBL Gene Tree for LPAR3 | Paralogs for LPAR3(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for LPAR3 gene
- S1PR42 LPAR22 LPAR12
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SNPs/Variants for LPAR3(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
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HapMap Linkage Disequilibrium images for LPAR3 (up to first 250kb)
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Disorders & Mutations for LPAR3
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 605106
10 Novoseek disease relationships for LPAR3 gene
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| ovarian cancer |
34.90 |
16 |
19001604 (3), 16018784 (3), 11775454 (1), 12759391 (1) |
| necrosis |
0.00 |
1 |
16228299 (1) |
| cancer |
0.00 |
9 |
12668280 (2), 15220934 (1), 17549306 (1), 16018784 (1) (see all 7) |
| inflammation |
0.00 |
1 |
18810336 (1) |
| obesity |
0.00 |
1 |
15544445 (1) |
| tumors |
0.00 |
16 |
19001604 (4), 18582227 (2), 16228299 (1), 17981673 (1) (see all 6) |
| adenocarcinoma |
0.00 |
1 |
16018784 (1) |
| metastasis |
0.00 |
1 |
18582227 (1) |
| prostate cancer |
0.00 |
4 |
11832770 (3) |
| carcinoma squamous cell |
0.00 |
2 |
12414665 (1), 12743035 (1) |
About this table
Human Genome Epidemiology Navigator: LPAR3 (1 document)
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Medical News for LPAR3(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for LPAR3 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/151 PubMed articles for LPAR3 gene (see all 151
):- Molecular cloning and characterization of a novel human G-protein- coupled receptor, EDG7, for lysophosphatidic acid. (PubMed id 10488122)1, 2, 3, 4 Bandoh K.... Inoue K. (1999)
- Molecular cloning and characterization of a lysophosphatidic acid receptor, Edg-7, expressed in prostate. (PubMed id 10727522)1, 3, 4 Im D.-S.... Lynch K.R. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Lysophosphatidic acid receptors. (PubMed id 11093753)3, 4 Contos J.J.A.... Chun J. (2000)
- Identification of an EDG7 variant, HOFNH30, a G-protein-coupled receptor for lysophosphatidic acid. (PubMed id 10891327)1, 3 Fitzgerald L.R.... Tsui P. (2000)
- Lysophosphatidic acid receptors determine tumorigenicity and aggressiveness of ovarian cancer cells. (PubMed id 19001604)1, 3 Yu S....Mills G.B. (2008)
- Expression of lysophosphatidic acid receptors and vascular endothelial growth factor mediating lysophosphatidic acid in the development of human ovarian cancer. (PubMed id 12668280)1, 3 Fujita T....Nakano H. (2003)
- Modulation of myocardial contractility by lysophosphatidic acid (LPA). (PubMed id 12623301)1, 3 Cremers B....Bohm M. (2003)
- Follow-up analysis of genome-wide association data identifies novel loci for type 1 diabetes. (PubMed id 18840781)3 Grant S.F....Hakonarson H. (2009)
- Gene expression profiles of lysophosphatidic acid-related molecules in the prostate: relevance to prostate cancer and benign hyperplasia. (PubMed id 19025891)3 Zeng Y....Wu X.X. (2009)
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Search for LPAR3
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
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Genome Databases showing LPAR3
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing LPAR3
(According to HUGE)
About This Section
| -- |
Specialized Databases showing LPAR3(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
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| About This Section
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| Services for LPAR3(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
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 Products for LPAR3:

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| | Recombinant Proteins (EDG7) | | Antibodies (EDG7) |
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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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