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LPAR3 Gene

protein-coding   GIFtS: 49

GC01M085048
lysophosphatidic acid receptor 3
(Previous names: endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 7 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: EDG7)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
EDG7 2, 3, 5
Edg-7 1, 2
FLJ98231 2
GPCR 2
HOFNH30 1, 2
LP-A3 1, 2
LPA-3 3
LPA3 1, 2, 3, 5
OTTHUMP00000011573 2
RP4-678I3 1, 2
Descriptions
LPA receptor 3 3
LPA receptor EDG7 2
Lysophosphatidic acid receptor Edg-7 3
calcium-mobilizing lysophosphatidic acid receptor LP-A3 2
endothelial cell differentiation gene 7 2
endothelial differentiation, lysophosphatidic acid
G-protein-coupled receptor, 7 1, 2
lysophosphatidic acid receptor 3 2
External Ids
HGNC: 142981
Entrez Gene: 235662
UniProtKB: Q9UBY53
Ensembl: ENSG000001715177
Search outside databases for aliases for LPAR3 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for LPAR3:
This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of
proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates
lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11)
alpha proteins. [provided by RefSeq]

UniProtKB/Swiss-Prot: LPAR3_HUMAN, Q9UBY5
Function: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May
play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q)
families of heteromeric G proteins

Gene Wiki entry for LPAR3 (EDG7)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22.3   Ensembl cytogenetic band:  1p22.3   HGNC cytogenetic band: 1p22.3

LPAR3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M085048:     (about GC identifiers)

Start:
85,052,089 bp from pter
End:
85,104,430 bp from pter
Size:
52,342 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000001.9  NT_032977.8  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: LPAR3_HUMAN, Q9UBY5 (See protein sequence)
Recommended Name: Lysophosphatidic acid receptor 3  
Size: 353 amino acids; 40128 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: A0AVA3

REFSEQ proteins: NP_036284.1  

ENSEMBL proteins: 
ENSP00000359643 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Millipore Purified and/or Recombinant LPAR3 Protein
Sigma-Aldrich Proteins for LPAR3  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (EDG7)
Human Recombinant Proteins from Abnova (LPAR3)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005886 plasma membrane TAS10488122
GO:0005887 integral to plasma membrane TAS10488122
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Antibodies for LPAR3: 
Invitrogen Antibodies for LPAR3
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for LPAR3
Browse R&D Systems for Antibodies
Antibodies from Abcam (EDG7), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (LPAR3)
Search Novus for antibodies for LPAR3

Assays for LPAR3: 
Invitrogen Assays for LPAR3
Millipore Kits and Assays for the Analysis of LPAR3
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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4 InterPro domains/families:
 IPR017452 GPCR_Rhodpsn_supfam
 IPR004065 LPA_rcpt
 IPR000276 7TM_GPCR_Rhodpsn
 IPR005385 LPA_rcpt_EDG7


   GeneDecks  LPAR3 for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry Q9UBY5

ProtoNet protein and cluster: Q9UBY5

2 Blocks protein families:
IPB004065 Lysophosphatidic acid receptor family signature
IPB005385 EDG-7 lysophosphatidic acid receptor signature


UniProtKB/Swiss-Prot: LPAR3_HUMAN, Q9UBY5
Similarity: Belongs to the G-protein coupled receptor 1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (LPAR3)
Millipore RNAi Products for the Analysis of LPAR3 Gene knock-down
Abnova Chimera RNAi Products for Gene knock-down (LPAR3)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_012152

              Applied Biosystems Silencer® siRNAs for LPAR3

              Sigma-Aldrich siRNA and siRNA Panels for LPAR3  
                     Sigma-Aldrich shRNA Panels and shRNA for LPAR3  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Millipore Clones for the Expression of LPAR3
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_012152
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_012152
                                 untagged cDNA clone in CMV expression vector: NM_012152 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_012152

UniProtKB/Swiss-Prot: LPAR3_HUMAN, Q9UBY5
Function: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May
play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q)
families of heteromeric G proteins

3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Lpar3):

embryogenesisreproductive system

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0001619 lysosphingolipid and lysophosphatidic acid receptor activity IEA--
GO:0004872 receptor activity IEA--
GO:0004930 G-protein coupled receptor activity TAS10488122
GO:0008289 lipid binding TAS10488122
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Invitrogen iPath™ Online BioAtlas - Pathway for LPAR3 (Maps provided by GeneGo):
 G-protein families signaling pathway

   GeneDecks  LPAR3 for the pathways selected above  
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1 Kegg Pathway  (Kegg details for LPAR3):
 hsa04080 Neuroactive ligand-receptor interaction

   GeneDecks  LPAR3 for the pathways selected above  
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5/29 Interacting proteins for LPAR3 (ENSP000003596433) via UniProtKB, MINT, and/or STRING (see all 29 )
InteractantInteraction Details
GeneCardExternal ID(s)
PLD2ENSP000002630883STRING (score=.956)
IL8ENSP000003065123STRING (score=.948)
EGFRENSP000002754933STRING (score=.932)
GNA15ENSP000002629583STRING (score=.918)
PTK2ENSP000003411893STRING (score=.911)
About this table

5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

GO IDQualified GO termEvidencePubMed IDs
GO:0000187 activation of MAPK activity IEA--
GO:0007165 signal transduction IEA--
GO:0007187 G-protein signaling, coupled to cyclic nucleotide second messenger TAS10488122
GO:0007204 elevation of cytosolic calcium ion concentration TAS10488122
GO:0007268 synaptic transmission TAS10488122
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for LPAR3
10/13 Novoseek chemical compound relationships for LPAR3 gene (see all 13 )
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
lysophospholipid 68.18 1 10818447 (1)
lipid 50.03 20 16093494 (2), 15993425 (2), 18491052 (2), 16246064 (2) (see all 12)
sphingosine 47.44 1 18058948 (1)
tyrosine 45.98 13 12548551 (3), 9398658 (1), 14567755 (1), 18558100 (1) (see all 9)
cyclic amp 40.37 7 18224335 (1), 18606183 (1), 18155068 (1)
calcium 29.62 19 10727522 (3), 16228299 (3), 9790898 (1), 18606183 (1) (see all 8)
phospholipid 20.73 3 15220934 (1), 17452637 (1), 18952848 (1)
fatty acid 6.68 2 10818460 (1), 10922489 (1)
atp 0.00 1 18495810 (1)
oligonucleotide 0.00 1 9398636 (1)
About this table


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (LPAR3)
Millipore RNAi Products for the Analysis of LPAR3 Gene knock-down
Abnova Chimera RNAi Products for Gene knock-down (LPAR3)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_012152

              Sigma-Aldrich siRNA and siRNA Panels for LPAR3  
                     Sigma-Aldrich shRNA Panels and shRNA for LPAR3  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_012152  

REFSEQ mRNAs for LPAR3 gene: 

NM_012152.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_012152  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_012152
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_012152
                                 untagged cDNA clone in CMV expression vector: NM_012152 

Additional cDNA sequence: 

AF127138.1 AF186380.1 AF236117.1 AK308283.1 AY322547.1 BC126268.1 BC126270.1 BC144021.1 

4 DOTS entries:

DT.91754582  DT.91798222  DT.91816580  DT.91926752 

24/33 AceView cDNA sequences (see all 33 ):

BU633960 AI288165 AF186380 AW274018 AI223077 BX283404 AY322547 BM999782 
BQ775090 AI432375 BG215668 AK091731 CD557613 AA446859 AF127138 AW172356 
NM_012152 CD103667 CB140352 AI567144 CB147705 CF121369 BG207736 BG209342 

Unigene Cluster for LPAR3:

Lysophosphatidic acid receptor 3
Hs.674915  [show with all ESTs]
Unigene Representative Sequence: NM_012152


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000370611  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

LPAR3 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for LPAR3

1 / 2

2 probe-sets matching LPAR3 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

220816_at2 U133-A 1 1.00 1.00 -- -- -- -- -- -- --

220816_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
About this table
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.674915

UniProtKB/Swiss-Prot: LPAR3_HUMAN, Q9UBY5
Tissue specificity: Most abundantly expressed in prostate, testes, pancreas, and heart, with
moderate levels in lung and ovary. No detectable expression in brain, placenta, liver, skeletal
muscle, kidney, spleen, thymus, small intestine, colon, or peripheral blood leukocytes

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for LPAR3 gene from 5/8 species (see all 8 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
LPAR31   -- lysophosphatidic acid receptor 3 90.65(n)
93.77(a)
490187  XM_547308.2  XP_547308.2 
chimpanzee
(Pan troglodytes)
LPAR31   -- lysophosphatidic acid receptor 3 99.43(n)
99.43(a)
736110  XM_001139887.1  XP_001139887.1 
cow
(Bos taurus)
LPAR31   -- lysophosphatidic acid receptor 3 89.2(n)
91.48(a)
532829  XM_612024.3  XP_612024.2 
rat
(Rattus norvegicus)
Lpar31   -- lysophosphatidic acid receptor 3 84.4(n)
91.28(a)
66025  NM_023969.1  NP_076459.1 
mouse
(Mus musculus)
Lpar31, 5 3 (70.50 cM)5
lysophosphatidic acid receptor 31, 5 84.8(n)1
91.5(a)1
650861  NM_022983.31  NP_075359.11 
 AF2723645  AF2723655  (see all 12)
About this table        Species with no ortholog for LPAR3

ENSEMBL Gene Tree for LPAR3
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for LPAR3 gene
S1PR42  LPAR22  LPAR12  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/278 NCBI SNPs in LPAR3 are shown (see all 278 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 129)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 1 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs93241441,2
A,C,F,H85105237(+) TTCCAT/CAGGCA 1 -- ng3111Minor allele frequency- C:0.35NA EU EA WA 944
--
rs97304231,2
A,C,F,H85106384(+) GATAGC/TAtttt 1 -- ng314Minor allele frequency- T:0.11EU EA WA 416
rs97290181,2
A,C,F,H85051665(+) AAAAAT/CACCAT 1 -- ng514Minor allele frequency- C:0.20EU EA WA 418
rs13252731,2
A,C,F,H85104708(+) CATGGC/TGGGTA 1 -- ng318Minor allele frequency- T:0.33EA NA EU WA 634
rs13252741,2
C,F,H85105118(+) CCTTCC/TTTACC 1 -- ng31 trp34Minor allele frequency- T:0.15EU EA WA 418
rs127563731,2
C,F,H85105770(+) AGAAGA/CCCAGA 1 -- ng31 tfbs38Minor allele frequency- C:0.03EU EA WA 838
--
rs97303421,2
A,C85105709(+) AGAAGC/TCCCCA 1 -- ng310--------
rs171167391,2
F,H85105930(+) ACTGGG/CAGTAG 1 -- ng317Minor allele frequency- C:0.02NA EU EA WA 548
rs357455431,2
C,F85103700(-) CCGCCG/AGAGGA 1 Q/R mis15Minor allele frequency- A:0.00NA EU EA WA 498
--
rs93241451,2
C85105705(+) CAGTAA/GAAGTC 1 -- ng310--------
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HapMap Linkage Disequilibrium images for LPAR3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 605106

10 Novoseek disease relationships for LPAR3 gene

Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
ovarian cancer 34.90 16 19001604 (3), 16018784 (3), 11775454 (1), 12759391 (1)
necrosis 0.00 1 16228299 (1)
cancer 0.00 9 12668280 (2), 15220934 (1), 17549306 (1), 16018784 (1) (see all 7)
inflammation 0.00 1 18810336 (1)
obesity 0.00 1 15544445 (1)
tumors 0.00 16 19001604 (4), 18582227 (2), 16228299 (1), 17981673 (1) (see all 6)
adenocarcinoma 0.00 1 16018784 (1)
metastasis 0.00 1 18582227 (1)
prostate cancer 0.00 4 11832770 (3)
carcinoma squamous cell 0.00 2 12414665 (1), 12743035 (1)
About this table

Human Genome Epidemiology Navigator: LPAR3 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/151 PubMed articles for LPAR3 gene (see all 151 ):
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 23566 HGNC: 14298 AceView: EDG7 Ensembl:ENSG00000171517 euGenes: HUgn23566
ECgene: LPAR3 H-InvDB: LPAR3
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
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  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for LPAR3:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



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 Predesigned and custom siRNAs for LPAR3 Antibodies for LPAR3
 Explore super-pooled esiRNAs Proteins for LPAR3
 Lentivirus-delivered shRNAs for LPAR3 Browse small molecules at Sigma-Aldrich
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 Search Novus for antibodies for LPAR3

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