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LPAR2 Gene

protein-coding GIFtS: 54

GC19M019597

lysophosphatidic acid receptor 2
(Previous names: endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 4 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: EDG4)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EDG-4 ^¹, ²
EDG4 ^², ³, ⁵
FLJ93869 ^²
LPA-2 ^³
LPA2 ^¹, ², ³

Descriptions
G protein-coupled receptor ^²
LPA receptor 2 ^³
LPA receptor EDG4 ^²
Lysophosphatidic acid receptor Edg-4 ^³
endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 4 ^¹, ²
lysophosphatidic acid receptor 2 ^²
lysophosphatidic acid receptor EDG4 ^²

External Ids
HGNC: 3168¹
Entrez Gene: 9170²
UniProtKB: Q9HBW0³
Ensembl: ENSG00000064547⁷

Search outside databases for aliases for LPAR2 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for LPAR2:

This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG

family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and

contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through

association with Gi and Gq proteins. An alternative splice variant has been described but its full

length sequence has not been determined. [provided by RefSeq]

UniProtKB/Swiss-Prot: LPAR2_HUMAN, Q9HBW0

Function: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities.

Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins.

Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway

Gene Wiki entry for LPAR2 (EDG4)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p12 Ensembl cytogenetic band: 19p13.11 HGNC cytogenetic band: 19p12

LPAR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M019597: (about GC identifiers)

Start:	19,595,477 bp from pter
End:	19,600,018 bp from pter
Size:	4,542 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000019.8 NT_011295.10

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: LPAR2_HUMAN, Q9HBW0 (See protein sequence)

Recommended Name: Lysophosphatidic acid receptor 2

Size: 351 amino acids; 39084 Da

Subunit: Interacts with SLC9A3R2/NHERF2, MAGI3 and PLCB3

Subcellular location: Cell membrane; Multi-pass membrane protein

Miscellaneous: PubMed:9525886 cDNA clone has a guanine nucleotide deletion that causes a frameshift

near its C-terminal coding region. This likely reflects a somatic mutation in the ovary tumor

cells from which the cDNA was isolated and may have altered the function of the encoded receptor,

and contributed to transformation of the original ovary cells that formed a tumor

Sequence caution: Sequence=AAC27728.1; Type=Frameshift; Positions=348;

Secondary accessions: O00543 O43431

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_004711.2

ENSEMBL proteins:

ENSP00000384665 ENSP00000351659

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (EDG4)
	Human Recombinant Proteins from Abnova (LPAR2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	9525886
GO:0005887	integral to plasma membrane	TAS	9525886

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Antibodies for LPAR2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for LPAR2
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (EDG4), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (LPAR2)
	Search Novus for antibodies for LPAR2

Assays for LPAR2:

	Invitrogen Assays for LPAR2
	Millipore Kits and Assays for the Analysis of LPAR2
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9HBW0

ProtoNet protein and cluster: Q9HBW0

2 Blocks protein families:

IPB004065 Lysophosphatidic acid receptor family signature

IPB004066 EDG-4 lysophosphatidic acid receptor signature

UniProtKB/Swiss-Prot: LPAR2_HUMAN, Q9HBW0

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LPAR2)
		Millipore RNAi Products for the Analysis of LPAR2 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (LPAR2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004720

Applied Biosystems Silencer® siRNAs for LPAR2

Sigma-Aldrich siRNA and siRNA Panels for LPAR2

Sigma-Aldrich shRNA Panels and shRNA for LPAR2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for LPAR2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_004720
Myc/DDK tagged cDNA clone in CMV expression vector: NM_004720
untagged cDNA clone in CMV expression vector: NM_004720

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004720

UniProtKB/Swiss-Prot: LPAR2_HUMAN, Q9HBW0

Function: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities.

Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins.

Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway

1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Lpar2):

normal

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001619	lysosphingolipid and lysophosphatidic acid receptor activity	IEA	--
GO:0004872	receptor activity	IEA	--
GO:0004930	G-protein coupled receptor activity	TAS	9525886
GO:0005515	protein binding	IPI	16203867
GO:0008289	lipid binding	TAS	9525886

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for LPAR2

5/36 Interacting proteins for LPAR2 (Q9HBW0¹ ENSP00000351659³) via UniProtKB, MINT, and/or STRING (see all 36 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SLC9A3R2	Q15599¹, ENSP00000191922³	EBI-765995, EBI-1149760 STRING (score=.996)
CFTR	P13569¹	EBI-765995, EBI-349854
TRIP6	ENSP00000200457³	STRING (score=.997)
GNAQ	ENSP00000286548³	STRING (score=.958)
IL8	ENSP00000306512³	STRING (score=.958)

About this table

5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000187	activation of MAPK activity	IEA	--
GO:0007165	signal transduction	IEA	--
GO:0007186	G-protein coupled receptor protein signaling pathway	TAS	9525886
GO:0007202	activation of phospholipase C activity	TAS	9804623
GO:0007204	elevation of cytosolic calcium ion concentration	TAS	9804623

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for LPAR2
5 Novoseek chemical compound relationships for LPAR2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
lysophospholipid	78.28	2	10729222 (1), 10753843 (1)
phospholipid	50.40	3	15220934 (1), 15755723 (1), 16890224 (1)
lipid	39.16	1	15280372 (1)
calcium	3.85	15	9804623 (8), 18178086 (1)
fatty acid	0.00	2	10488122 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LPAR2)
		Millipore RNAi Products for the Analysis of LPAR2 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (LPAR2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004720

Sigma-Aldrich siRNA and siRNA Panels for LPAR2

Sigma-Aldrich shRNA Panels and shRNA for LPAR2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004720

REFSEQ mRNAs for LPAR2 gene:

NM_004720.5

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004720

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004720
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004720
                                 untagged cDNA clone in CMV expression vector: NM_004720

Additional cDNA sequence:

AF011466.1 AF197929.1 AF233092.1 AK123043.1 AK316573.1 AY322548.1 BC025695.1 CR598581.1

CR623876.1

11 DOTS entries:

DT.411501 DT.100777864 DT.121493202 DT.101979545 DT.86857033 DT.121493024 DT.121493161 DT.95267721

DT.95342006 DT.121493146 DT.95308057

24/71 AceView cDNA sequences (see all 71 ):

AF233092 BC025695 AU133824 AU124778 NM_004720 CR598581 CR623876 AL552902

AA470437 BM720743 BX279964 BM840024 BM725367 BI915073 BM682738 AY322548

AL553876 AI825791 BI761906 BX328368 AI224123 BM850217 AF197929 CD244423

Unigene Cluster for LPAR2:

Lysophosphatidic acid receptor 2

Hs.122575 [show with all ESTs]

Unigene Representative Sequence: AK123043

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for LPAR2 (see all 11 )

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	^	3a	·	3b	·	3c	·	3d	·	3e	^	4	^	5a	·	5b	·	5c	·	5d	·	5e	·	5f	·	5g	·	5h	·	5i	^	6
SP1:					-		-										-		-				-
SP2:					-												-		-				-
SP3:					-		-		-		-		-		-		-		-				-
SP4:											-		-		-		-		-				-
SP5:											-		-		-		-		-		-		-

About this scheme

ECgene alternative splicing isoforms for LPAR2

2 Ensembl transcripts including schematic representations:

ENST00000407877 ENST00000358804

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

LPAR2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for LPAR2

¹ / ²

5 probe-sets matching LPAR2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37769_at²	U95-A	1	1.00	1.00	1.00	1.00	--	--	--	--	--
206723_s_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
206722_s_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
206723_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
206722_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTACCCGGTA

SOURCE GeneReport for Unigene cluster: Hs.122575
UniProtKB/Swiss-Prot: LPAR2_HUMAN, Q9HBW0
Tissue specificity: Expressed most abundantly in testes and peripheral blood leukocytes with less
expression in pancreas, spleen, thymus and prostate. Little or no expression in heart, brain,
placenta, lung, liver, skeletal muscle, kidney, ovary, small intestine, or colon

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for LPAR2 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LPAR2¹	--	lysophosphatidic acid receptor 2	90.41(n) 96.01(a)	484802 XM_541918.2 XP_541918.2
chimpanzee (Pan troglodytes)	LPAR2¹	--	lysophosphatidic acid receptor 2	99.24(n) 99.15(a)	455878 XM_512529.2 XP_512529.2
cow (Bos taurus)	LPAR2¹	--	lysophosphatidic acid receptor 2	88.13(n) 94.02(a)	509748 XM_586777.3 XP_586777.3
rat (Rattus norvegicus)	Lpar2¹	--	lysophosphatidic acid receptor 2	86.02(n) 93.1(a)	498609 XM_573887.2 XP_573887.1
mouse (Mus musculus)	Lpar2^{1, 5}	8 (33.50 cM)⁵	lysophosphatidic acid receptor 2^{1, 5}	86.59(n)¹ 92.24(a)¹	53978¹ NM_020028.3¹ NP_064412.2¹ AA118482⁵ AF218844⁵ (see all 12)

About this table Species with no ortholog for LPAR2

ENSEMBL Gene Tree for LPAR2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for LPAR2 gene

S1PR4² LPAR1² LPAR3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/18 NCBI SNPs in LPAR2 are shown (see all 18 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 25)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1054685^1,2	A,C,F,H,O	19595539(-)	`TCCCCG/AATAGA`	1	--	ut3¹ ese³		6		EA MN EU WA	2090
	rs33982830^1,2	C,F	19598686(+)	`AGCTGC/TACGGC`	1	V/V	syn¹		1		NA	64
	rs35382615^1,2	F	19598680(+)	`CTGTGC/TAGCTG`	1	L/L	syn¹		1		NA	54
	rs1266503^1,2	C	19596257(+)	`ACCAGT/GGAGTT`	1	S/S	syn¹ ese³		3		NA MN	212
	rs873870^1,2	A,C,F,H	19599554(+)	`GTGAGG/ATCACT`	1	--	int¹		8		NA EA EU WA	2150
	rs2002318^1,2	C,H	19599506(+)	`CCGGAG/TTCAGT`	1	--	int¹		4		EU EA WA	418
	rs36020172^1,2	--	19600465(-)	`TGGGCA/GGGGGT`	1	--	ng3¹		0	--	--	--	--
	rs35252059^1,2	--	19595733(-)	`TGATGC/GTGAGG`	1	--	ut3¹		0	--	--	--	--
--	rs7247165^1,2	--	19595164(+)	`tggacA/Gtggtg`	1	--	ng5¹		0	--	--	--	--
	rs34993784^1,2	--	19596371(+)	`ACCACG/AAACGC`	1	F/F	syn¹		1		NA	70

About this table

HapMap Linkage Disequilibrium images for LPAR2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 605110

8 Novoseek disease relationships for LPAR2 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
ovarian cancer	52.87	17	19001604 (3), 18461672 (2), 10818454 (1), 11775454 (1) (see all 7)
cancer	30.61	17	16353194 (4), 12668280 (2), 19025891 (1), 9525886 (1) (see all 9)
colon cancer	24.55	8	15728708 (3), 15837931 (2), 12670925 (1), 16904289 (1)
tumors	15.41	14	19001604 (5), 16353194 (2), 19025891 (1), 18178086 (1) (see all 6)
metastasis	5.37	2	19081821 (1), 19116446 (1)
gastric cancer	0.61	3	16353194 (2), 15530853 (1)
breast cancer	0.00	2	10493533 (1), 15535846 (1)
colorectal cancer	0.00	6	15220934 (3), 15837931 (1)

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/87 PubMed articles for LPAR2 gene (see all 87 ):

Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid. (PubMed id 9525886)^{1, 2, 3, 4} An S.... Goetzl E.J. (1998)
Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization. (PubMed id 9804623)^{1, 2, 3} An S....Goetzl E.J. (1998)
MAGI-3 regulates LPA-induced activation of Erk and RhoA. (PubMed id 16904289)^{1, 3, 4} Zhang H....Yun C.C. (2007)
NHERF2 specifically interacts with LPA2 receptor and defines the specificity and efficiency of receptor-mediated phospholipase C-beta3 activation. (PubMed id 15143197)^{1, 3, 4} Oh Y.-S.... Suh P.-G. (2004)
Genomic characterization of the lysophosphatidic acid receptor gene, lp(A2)/Edg4, and identification of a frameshift mutation in a previously characterized cDNA. (PubMed id 10729222)^{1, 3, 4} Contos J.J.A. and Chun J. (2000)
Lysophosphatidic acid (LPA) receptors of the EDG family are differentially activated by LPA species. Structure-activity relationship of cloned LPA receptors. (PubMed id 10922489)^{1, 3, 4} Bandoh K.... Inoue K. (2000)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)^{3, 4} Grimwood J.... Lucas S.M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Lysophosphatidic acid receptors. (PubMed id 11093753)^{3, 4} Contos J.J.A.... Chun J. (2000)
Lysophosphatidic acid receptors determine tumorigenicity and aggressiveness of ovarian cancer cells. (PubMed id 19001604)^{1, 3} Yu S....Mills G.B. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 9170	HGNC: 3168	AceView: EDG4	Ensembl:ENSG00000064547	euGenes: HUgn9170
ECgene: LPAR2	H-InvDB: LPAR2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for LPAR2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for LPAR2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for LPAR2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for LPAR2		Antibodies for LPAR2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for LPAR2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Antibodies (LPAR2)
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	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Antibodies (EDG4)

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Search Tocris compounds for LPAR2

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Search Novus for antibodies for LPAR2

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LPAR2 Gene

protein-coding GIFtS: 54

Aliases &
Descriptions
for LPAR2

Summaries
for LPAR2

Genomic Location
for LPAR2

Proteins
for LPAR2

Protein Domains/
Families
for LPAR2

Gene Function
for LPAR2

Pathways & Interactions
for LPAR2

Drugs & Compounds
for LPAR2

Transcripts
for LPAR2

Expression
for LPAR2

Orthologs
for LPAR2

Paralogs
for LPAR2

SNPs/Variants
for LPAR2

Disorders & Mutations
for LPAR2

Medical News
for LPAR2

Publications
for LPAR2

Search for LPAR2

Genome Databases showing LPAR2

Other Databases showing LPAR2

Specialized Databases showing LPAR2

Licensable Technologies
for LPAR2

Services
for LPAR2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

LPAR2 Gene

protein-coding GIFtS: 54

Aliases & Descriptionsfor LPAR2

Summariesfor LPAR2

Genomic Locationfor LPAR2

Proteinsfor LPAR2

Protein Domains/Familiesfor LPAR2

Gene Functionfor LPAR2

Pathways & Interactionsfor LPAR2

Drugs & Compoundsfor LPAR2

Transcriptsfor LPAR2

Expression for LPAR2

Orthologsfor LPAR2

Paralogsfor LPAR2

SNPs/Variantsfor LPAR2

Disorders & Mutationsfor LPAR2

Medical Newsfor LPAR2

Publicationsfor LPAR2

Search for LPAR2

Genome Databases showing LPAR2

Other Databases showing LPAR2

Specialized Databases showing LPAR2

Licensable Technologiesfor LPAR2

Servicesfor LPAR2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for LPAR2

Summaries
for LPAR2

Genomic Location
for LPAR2

Proteins
for LPAR2

Protein Domains/
Families
for LPAR2

Gene Function
for LPAR2

Pathways & Interactions
for LPAR2

Drugs & Compounds
for LPAR2

Transcripts
for LPAR2

Expression
for LPAR2

Orthologs
for LPAR2

Paralogs
for LPAR2

SNPs/Variants
for LPAR2

Disorders & Mutations
for LPAR2

Medical News
for LPAR2

Publications
for LPAR2

Licensable Technologies
for LPAR2

Services
for LPAR2