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S1PR3 Gene

protein-coding GIFtS: 49

GC09P090797

sphingosine-1-phosphate receptor 3
(Previous names: endothelial differentiation, sphingolipid G-protein-coupled receptor, 3 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: EDG3)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
EDG-3 ^¹, ²
EDG3 ^², ³, ⁵
FLJ37523 ^²
FLJ93220 ^²
LPB3 ^²
MGC71696 ^²
OTTHUMP00000021612 ^²
S1P3 ^², ³

Descriptions
Endothelial differentiation G-protein coupled receptor 3 ^³
G protein-coupled receptor, endothelial differentiation gene-3 ^²
S1P receptor 3 ^³
S1P receptor EDG3 ^²
S1P receptor Edg-3 ^³
Sphingosine 1-phosphate receptor Edg-3 ^³
endothelial differentiation, sphingolipid G-protein-coupled receptor, 3 ^¹, ²
sphingosine 1-phosphate receptor 3 ^²
sphingosine-1-phosphate receptor 3 ^²

External Ids
HGNC: 3167¹
Entrez Gene: 1903²
UniProtKB: Q99500³
Ensembl: ENSG00000213694⁷

Search outside databases for aliases for S1PR3 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for S1PR3:

This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors.

This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely

contributes to the regulation of angiogenesis and vascular endothelial cell function. [provided by

RefSeq]

UniProtKB/Swiss-Prot: S1PR3_HUMAN, Q99500

Function: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive

lysophospholipid that elicits diverse physiological effect on most types of cells and tissues.

When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation

and suppression of apoptosis

Gene Wiki entry for S1PR3 (EDG3)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22.1-q22.2 Ensembl cytogenetic band: 9q22.1 HGNC cytogenetic band: 9q22.1-q22.2

S1PR3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P090797: (about GC identifiers)

Start:	90,796,182 bp from pter
End:	90,809,745 bp from pter
Size:	13,564 bases
Orientation:	plus strand

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: S1PR3_HUMAN, Q99500 (See protein sequence)

Recommended Name: Sphingosine 1-phosphate receptor 3

Size: 378 amino acids; 42250 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Secondary accessions: Q5SQD8 Q7Z5I2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_005217.2

ENSEMBL proteins:

ENSP00000350878 ENSP00000365006

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant S1PR3 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (EDG3)
	Human Recombinant Proteins from Abnova (S1PR3)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	9409733
GO:0005887	integral to plasma membrane	TAS	9409733

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Antibodies for S1PR3:

	Invitrogen Antibodies for S1PR3
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for S1PR3
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (EDG3), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (S1PR3)
	Novus Biologicals Antibodies for S1PR3

Assays for S1PR3:

	Invitrogen Assays for S1PR3
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q99500

ProtoNet protein and cluster: Q99500

2 Blocks protein families:

IPB004061 Sphingosine 1-phosphate receptor family signature

IPB004062 EDG-3 sphingosine 1-phosphate receptor signature

UniProtKB/Swiss-Prot: S1PR3_HUMAN, Q99500

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (S1PR3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (S1PR3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005226

Applied Biosystems Silencer® siRNAs for S1PR3

Sigma-Aldrich siRNA and siRNA Panels for S1PR3

Sigma-Aldrich shRNA Panels and shRNA for S1PR3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for S1PR3
		Millipore Clones for the Expression of S1PR3

OriGene GFP tagged cDNA clone in CMV expression vector: NM_005226
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005226
untagged cDNA clone in CMV expression vector: NM_005226

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005226

UniProtKB/Swiss-Prot: S1PR3_HUMAN, Q99500

Function: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive

lysophospholipid that elicits diverse physiological effect on most types of cells and tissues.

When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation

and suppression of apoptosis

13 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for S1pr3):

	behavior/neurological	cellular	hearing/vestibular/ear	homeostasis/metabolism
immune system	lethality-prenatal/perinatal	limbs/digits/tail	nervous system	normal
reproductive system	respiratory system	skin/coat/nails

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001619	lysosphingolipid and lysophosphatidic acid receptor activity	IEA	--
GO:0004872	receptor activity	IEA	--
GO:0004930	G-protein coupled receptor activity	TAS	10555146
GO:0008289	lipid binding	TAS	9409733

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for S1PR3 (Your Favorite Gene powered by Ingenuity)

Ceramide Signaling
Human Embryonic Stem Cell Pluripotency

GeneDecks S1PR3 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for S1PR3

5/30 Interacting proteins for S1PR3 (ENSP00000350878³) via UniProtKB, MINT, and/or STRING (see all 30 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AKT1	ENSP00000270202³	STRING (score=.981)
GNAQ	ENSP00000286548³	STRING (score=.975)
MBTPS1	ENSP00000344223³	STRING (score=.966)
GNA13	ENSP00000239138³	STRING (score=.96)
MAPK3	ENSP00000263025³	STRING (score=.958)

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5/9 Gene Ontology (GO) biological process terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001816	cytokine production	IEA	--
GO:0006954	inflammatory response	TAS	8649355
GO:0007165	signal transduction	IEA	--
GO:0007186	G-protein coupled receptor protein signaling pathway	TAS	10617617
GO:0007193	inhibition of adenylate cyclase activity by G-protein signaling	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for S1PR3:

Mixed Agonist/Antagonist Antagonist

Compounds for S1PR3 available from Tocris Bioscience

Compound	Action	CAS number
Sphingosine-1-phosphate	Endogenous agonist at S1P1-5	[26993-30-6]

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9 Novoseek chemical compound relationships for S1PR3 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
dhs-1-p	91.71	1	10626811 (1)
sphingosylphosphorylcholine	88.98	4	10381367 (2), 9409733 (1)
sphingosine	82.56	1	16636149 (1)
lysophospholipid	81.97	1	10753843 (1)
lipid	42.14	4	10794715 (2), 12775579 (1), 9928946 (1)
phosphatidylinositol	26.40	1	17046831 (1)
calcium	14.73	16	10220556 (6), 9928946 (3), 10383399 (2), 9878524 (2) (see all 5)
cyclic amp	6.59	2	10381367 (1)
tyrosine	0.00	2	18834877 (1), 11544274 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (S1PR3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (S1PR3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005226

Sigma-Aldrich siRNA and siRNA Panels for S1PR3

Sigma-Aldrich shRNA Panels and shRNA for S1PR3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005226

REFSEQ mRNAs for S1PR3 gene:

NM_005226.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005226

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005226
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005226
                                 untagged cDNA clone in CMV expression vector: NM_005226

24/122 AceView cDNA sequences (see all 122 ):

CK905851 BM997301 AA375607 BQ668511 AI874145 AL832194 AI658766 BC060827

AI473541 AI141395 AK130650 CA447674 BX090228 AA234027 AA424364 AW137598

BF589582 BF475629 BM705261 CA427601 AI400436 BM994343 AL536342 BM729144

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000358157 ENST00000375846

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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S1PR3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for S1PR3

¹ / ²

6 probe-sets matching S1PR3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
80110_at²	U95-D	1	1.00	1.00	0.79	1.05	--	--	--	--	--
46116_at²	U95-B	2	1.00	0.59	0.96	0.96	--	--	--	--	--
231741_at²	U133-B	2	1.00	0.95	--	--	--	--	--	--	--
228176_at²	U133-B	2	1.00	0.73	--	--	--	--	--	--	--
231741_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--
228176_at²	U133Plus2	2	1.00	0.73	--	--	--	--	--	--	--

GeneDecks S1PR3 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --
UniProtKB/Swiss-Prot: S1PR3_HUMAN, Q99500
Tissue specificity: Expressed in all tissues, but most abundantly in heart, placenta, kidney, and
liver

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for S1PR3 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	S1PR3¹	--	sphingosine-1-phosphate receptor 3	86.74(n) 87.8(a)	484199 XM_541315.2 XP_541315.2
chimpanzee (Pan troglodytes)	S1PR3¹	--	sphingosine-1-phosphate receptor 3	99.74(n) 99.74(a)	464580 XM_520117.2 XP_520117.2
cow (Bos taurus)	S1PR3¹	--	sphingosine-1-phosphate receptor 3	86.4(n) 88(a)	539123 XM_001252512.1 XP_001252513.1
rat (Rattus norvegicus)	S1pr3¹	--	sphingosine-1-phosphate receptor 3	86.7(n) 89.89(a)	306792 XM_225216.4 XP_225216.2
mouse (Mus musculus)	S1pr3^{1, 5}	13⁵	sphingosine-1-phosphate receptor 3^{1, 5}	85.55(n)¹ 88.03(a)¹	13610¹ NM_010101.3¹ NP_034231.1¹ AA034780⁵ AB028143⁵ (see all 26)

About this table Species with no ortholog for S1PR3

ENSEMBL Gene Tree for S1PR3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for S1PR3 gene

S1PR1² S1PR2² S1PR5²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/33 NCBI SNPs in S1PR3 are shown (see all 33 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 58)

AB	SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs7853537^1,2	A,C,F,H	90807922(+)	`GAAGCA/GGACGG`	1	--	ut3¹		7		NA EU EA WA	542
	rs34075341^1,2	C,F	90806663(+)	`GCTGCG/AGACCG`	1	Q/R	mis¹		5		NA EU EA WA	482
	rs7865415^1,2	H	90807926(+)	`CAGACG/AGCTGG`	1	--	ut3¹		4		EU EA WA	396
	rs34962307^1,2	C	90806565(+)	`GTGACC/GATCGT`	1	T/T	syn¹		1		NA	76
--	rs6559333^1,2	A,C,F,H	90801401(+)	`tgcagC/Ggtccg`	1	--	int¹		7		EU EA WA NA	560
	rs7038457^1,2	A,C,F,H	90802886(+)	`CCAGTT/CCCTGT`	1	--	int¹		15		EU EA WA NA	1400
	rs7858626^1,2	A,C,F,H	90802459(+)	`CCAGCA/GATCTG`	1	--	int¹		8		EU EA WA	836
--	rs7870888^1,2	A,C,F	90802703(+)	`CTCGCG/AGTCCC`	1	--	int¹		3		NA	136
--	rs41287353^1,2	--	90808153(+)	`GTGACC/TATCAG`	1	--	ut3¹		0	--	--	--	--
--	rs41287347^1,2	--	90806435(+)	`CTTCAC/TGCTGG`	1	T/M	mis¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for S1PR3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 601965

6 Novoseek disease relationships for S1PR3 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation	19.88	1	18305483 (1)
glioblastoma	16.48	1	12175535 (1)
breast cancer	1.63	1	10493533 (1)
necrosis	0.00	1	18658144 (1)
cancer	0.00	1	15466859 (1)
tumors	0.00	1	18658144 (1)

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(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/94 PubMed articles for S1PR3 gene (see all 94 ):

Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids. (PubMed id 9409733)^{1, 2, 3, 4} An S....Goetzl E.J. (1997)
Molecular cloning of the novel human G protein-coupled receptor (GPCR) gene mapped on chromosome 9. (PubMed id 8878560)^{1, 2, 3, 4} Yamaguchi F....Brenner S. (1996)
Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5. (PubMed id 10383399)^{1, 3, 4} Ancellin N. and Hla T. (1999)
Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5. (PubMed id 10617617)^{1, 3, 4} An S.... Bleu T. (2000)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Evidence for Edg-3 receptor-mediated activation of I(K.ACh) by sphingosine-1-phosphate in human atrial cardiomyocytes. (PubMed id 10908314)^{3, 4} Himmel H.M.... Ravens U. (2000)
Sphingosine 1-phosphate-induced cell rounding and neurite retraction are mediated by the G protein-coupled receptor H218. (PubMed id 9988698)^{1, 3} Van Brocklyn J.R....Spiegel S. (1999)
Attenuation of vascular permeability by methylnaltrexone: role of mOP-R and S1P3 transactivation. (PubMed id 17395891)^{1, 3} Singleton P.A....Garcia J.G. (2007)
Specific and overlapping sphingosine-1-phosphate receptor functions in human synoviocytes: impact of TNF-alpha. (PubMed id 18658144)^{1, 3} Zhao C....Bourgoin S.G. (2008)
Sphingosine 1-phosphate stimulates proliferation and migration of human endothelial cells possibly through the lipid receptors, Edg-1 and Edg-3. (PubMed id 10794715)^{1, 3} Kimura T....Okajima F. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 1903	HGNC: 3167	AceView: EDG3	Ensembl:ENSG00000213694	euGenes: HUgn1903
ECgene: S1PR3	H-InvDB: S1PR3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for S1PR3
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for S1PR3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for S1PR3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for S1PR3		Antibodies for S1PR3
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for S1PR3		Small molecules for S1PR3
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (S1PR3)
	Antibodies (S1PR3)
	Chimera RNAi (S1PR3)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (EDG3)
	Antibodies (EDG3)

Search OriGene for S1PR3

Tocris compounds for S1PR3

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for S1PR3

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S1PR3 Gene

protein-coding GIFtS: 49

Aliases &
Descriptions
for S1PR3

Summaries
for S1PR3

Genomic Location
for S1PR3

Proteins
for S1PR3

Protein Domains/
Families
for S1PR3

Gene Function
for S1PR3

Pathways & Interactions
for S1PR3

Drugs & Compounds
for S1PR3

Transcripts
for S1PR3

Expression
for S1PR3

Orthologs
for S1PR3

Paralogs
for S1PR3

SNPs/Variants
for S1PR3

Disorders & Mutations
for S1PR3

Medical News
for S1PR3

Publications
for S1PR3

Search for S1PR3

Genome Databases showing S1PR3

Other Databases showing S1PR3

Specialized Databases showing S1PR3

Licensable Technologies
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Services
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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

S1PR3 Gene

protein-coding GIFtS: 49

Aliases & Descriptionsfor S1PR3

Summariesfor S1PR3

Genomic Locationfor S1PR3

Proteinsfor S1PR3

Protein Domains/Familiesfor S1PR3

Gene Functionfor S1PR3

Pathways & Interactionsfor S1PR3

Drugs & Compoundsfor S1PR3

Transcriptsfor S1PR3

Expression for S1PR3

Orthologsfor S1PR3

Paralogsfor S1PR3

SNPs/Variantsfor S1PR3

Disorders & Mutationsfor S1PR3

Medical Newsfor S1PR3

Publicationsfor S1PR3

Search for S1PR3

Genome Databases showing S1PR3

Other Databases showing S1PR3

Specialized Databases showing S1PR3

Licensable Technologiesfor S1PR3

Servicesfor S1PR3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for S1PR3

Summaries
for S1PR3

Genomic Location
for S1PR3

Proteins
for S1PR3

Protein Domains/
Families
for S1PR3

Gene Function
for S1PR3

Pathways & Interactions
for S1PR3

Drugs & Compounds
for S1PR3

Transcripts
for S1PR3

Expression
for S1PR3

Orthologs
for S1PR3

Paralogs
for S1PR3

SNPs/Variants
for S1PR3

Disorders & Mutations
for S1PR3

Medical News
for S1PR3

Publications
for S1PR3

Licensable Technologies
for S1PR3

Services
for S1PR3