V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

LPAR1 Gene

protein-coding GIFtS: 59

GC09M112676

lysophosphatidic acid receptor 1
(Previous names: endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: EDG2)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EDG2 ^², ³, ⁵
GPR26 ^¹, ²
Gpcr26 ^¹, ²
LPA-1 ^³
LPA1 ^¹, ², ³, ⁵
Mrec1.3 ^¹, ²
OTTHUMP00000021903 ^²
OTTHUMP00000021904 ^²
OTTHUMP00000021905 ^²
VZG1 ^², ⁵
edg-2 ^¹, ²
rec.1.3 ^¹, ²
vzg-1 ^¹, ²

Descriptions
LPA receptor 1 ^³
Lysophosphatidic acid receptor Edg-2 ^³
endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2 ^¹, ²
lysophosphatidic acid receptor 1 ^²
ventricular zone gene 1 ^²

External Ids
HGNC: 3166¹
Entrez Gene: 1902²
UniProtKB: Q92633³
Ensembl: ENSG00000198121⁷

Search outside databases for aliases for LPAR1 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for LPAR1:

The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a

group known as EDG receptors. These receptors are members of the G protein-coupled receptor

superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions,

including proliferation, platelet aggregation, smooth muscle contraction, inhibition of

neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Two transcript variants

encoding the same protein have been identified for this gene [provided by RefSeq]

UniProtKB/Swiss-Prot: LPAR1_HUMAN, Q92633

Function: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities.

Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins

Gene Wiki entry for LPAR1 (EDG2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q31.3 Ensembl cytogenetic band: 9q31.3 HGNC cytogenetic band: 9q

LPAR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M112676: (about GC identifiers)

Start:	112,675,365 bp from pter
End:	112,840,186 bp from pter
Size:	164,822 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000009.10 NT_008470.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: LPAR1_HUMAN, Q92633 (See protein sequence)

Recommended Name: Lysophosphatidic acid receptor 1

Size: 364 amino acids; 41109 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Secondary accessions: O00656 O00722 P78351

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001392.2 NP_476500.1

ENSEMBL proteins:

ENSP00000363552 ENSP00000363553 ENSP00000351755

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant LPAR1 Protein
	Sigma-Aldrich Proteins for LPAR1
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (EDG2)
	Human Recombinant Proteins from Abnova (LPAR1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	9070858
GO:0005887	integral to plasma membrane	TAS	9070858

About this table

Antibodies for LPAR1:

	Invitrogen Antibodies for LPAR1
	Millipore Mono- and Polyclonal Antibodies for the study of LPAR1
	Sigma-Aldrich Antibodies for LPAR1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (EDG2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (LPAR1)
	Novus Biologicals Antibodies for LPAR1

Assays for LPAR1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q92633

ProtoNet protein and cluster: Q92633

2 Blocks protein families:

IPB002277 Lysophosphatidic acid receptor (EDG2) signature

IPB004065 Lysophosphatidic acid receptor family signature

UniProtKB/Swiss-Prot: LPAR1_HUMAN, Q92633

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LPAR1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (LPAR1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_057159

Applied Biosystems Silencer® siRNAs for LPAR1

Sigma-Aldrich siRNA and siRNA Panels for LPAR1

Sigma-Aldrich shRNA Panels and shRNA for LPAR1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for LPAR1
		Millipore Clones for the Expression of LPAR1

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001401
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001401
untagged cDNA clones in CMV expression vector (see all 2): NM_001401

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001401

UniProtKB/Swiss-Prot: LPAR1_HUMAN, Q92633

Function: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities.

Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins

9 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Lpar1):

	adipose tissue	behavior/neurological	craniofacial	growth/size
lethality-postnatal	lethality-prenatal/perinatal	nervous system	vision/eye

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001619	lysosphingolipid and lysophosphatidic acid receptor activity	IEA	--
GO:0004872	receptor activity	IEA	--
GO:0004930	G-protein coupled receptor activity	TAS	8922387
GO:0030165	PDZ domain binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for LPAR1

5/37 Interacting proteins for LPAR1 (ENSP00000363553³) via UniProtKB, MINT, and/or STRING (see all 37 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IL8	ENSP00000306512³	STRING (score=.963)
GNAI3	ENSP00000358867³	STRING (score=.96)
PLD2	ENSP00000263088³	STRING (score=.946)
PTK2B	ENSP00000332816³	STRING (score=.937)
EGFR	ENSP00000275493³	STRING (score=.924)

About this table

5/9 Gene Ontology (GO) biological process terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000187	activation of MAPK activity	IEA	--
GO:0007165	signal transduction	IEA	--
GO:0007186	G-protein coupled receptor protein signaling pathway	TAS	8922387
GO:0007202	activation of phospholipase C activity	TAS	9804623
GO:0007204	elevation of cytosolic calcium ion concentration	TAS	9804623

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for LPAR1
6 Novoseek chemical compound relationships for LPAR1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
lysophospholipid	82.89	2	9931453 (1), 11604399 (1)
diacylglycerol pyrophosphate	76.27	1	15618220 (1)
phospholipid	56.08	3	11604399 (1), 15220934 (1), 15755723 (1)
lysophosphatidylcholine	50.62	2	16627485 (1)
lipid	43.48	5	11723085 (1), 17156449 (1), 19081821 (1), 16210650 (1) (see all 5)
calcium	4.15	13	9804623 (8)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LPAR1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (LPAR1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_057159

Sigma-Aldrich siRNA and siRNA Panels for LPAR1

Sigma-Aldrich shRNA Panels and shRNA for LPAR1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001401 NM_057159

REFSEQ mRNAs for LPAR1 gene (2 alternative transcripts):

NM_001401.3 NM_057159.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001401 NM_057159

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001401
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001401
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001401

Additional cDNA sequence:

AK022808.1 AK290287.1 AK296374.1 AK298590.1 AK299279.1 AY322546.1 BC030615.2 BC036034.1

BC073167.1 U78192.1 U80811.1 Y09479.1

12 DOTS entries:

DT.97769991 DT.91735433 DT.91757548 DT.92026247 DT.121173151 DT.95135082 DT.121173152 DT.121173154

DT.102836420 DT.121173114 DT.121173164 DT.91672717

24/151 AceView cDNA sequences (see all 151 ):

AI168217 F06566 CB132447 BQ183686 BE140638 BE464013 NM_057159 BC036034

CB216093 AW953091 BQ019924 BX114078 NM_001401 AK022808 BQ446451 AI272801

AI678309 AI674417 BQ028223 BU838473 AU120057 BC073167 T32740 AA150119

Unigene Cluster for LPAR1:

Lysophosphatidic acid receptor 1

Hs.126667 [show with all ESTs]

Unigene Representative Sequence: BC036034

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for LPAR1 (see all 9 )

ExUns:	1	^	2	^	3a	·	3b	·	3c	·	3d	·	3e	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9a	·	9b	^	10	^	11a	·	11b	·	11c	^	12
SP1:																	-		-		-		-
SP2:															-		-		-		-		-								-
SP3:																	-		-		-		-								-
SP4:																															-
SP5:			-		-		-		-		-		-		-		-		-		-		-								-

About this scheme

ECgene alternative splicing isoforms for LPAR1

3 Ensembl transcripts including schematic representations:

ENST00000374430 ENST00000374431 ENST00000358883

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

LPAR1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for LPAR1

¹ / ²

9 probe-sets matching LPAR1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
40387_at²	U95-A	1	1.00	1.00	0.97	0.91	--	--	--	--	--
52170_at²	U95-B	1	1.00	1.00	0.96	1.51	--	--	--	--	--
77817_r_at²	U95-E	1	1.00	1.00	0.83	0.66	--	--	--	--	--
204037_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
204036_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
204038_s_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
204037_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
204036_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
204038_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks LPAR1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GGTGGCAGTT

SOURCE GeneReport for Unigene cluster: Hs.126667
UniProtKB/Swiss-Prot: LPAR1_HUMAN, Q92633
Tissue specificity: Expressed in many adult organs, including brain, heart, colon, small intestine,
placenta, prostate, ovary, pancreas, testes, spleen, skeletal muscle, and kidney. Little or no
expression in liver, lung, thymus, or peripheral blood leukocytes

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for LPAR1 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LPAR1¹	--	lysophosphatidic acid receptor 1	94.61(n) 98.55(a)	474800 XM_848441.1 XP_853534.1
chimpanzee (Pan troglodytes)	LPAR1¹	--	lysophosphatidic acid receptor 1	100(n) 100(a)	464655 XM_520185.2 XP_520185.1
cow (Bos taurus)	LPAR1¹	--	lysophosphatidic acid receptor 1	91.67(n) 96.7(a)	281136 NM_174047.2 NP_776472.1
rat (Rattus norvegicus)	Lpar1¹	--	lysophosphatidic acid receptor 1	89.56(n) 97.25(a)	116744 NM_053936.3 NP_446388.1
mouse (Mus musculus)	Lpar1^{1, 5}	4 (16.00 cM)⁵	lysophosphatidic acid receptor 1^{1, 5}	90.2(n)¹ 96.43(a)¹	14745¹ NM_010336.1¹ NP_034466.1¹ AF075452⁵ AF075453⁵ (see all 21)

About this table Species with no ortholog for LPAR1

ENSEMBL Gene Tree for LPAR1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for LPAR1 gene

S1PR4² LPAR2² LPAR3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1132 NCBI SNPs in LPAR1 are shown (see all 1132 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 345)

AB	SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs6833^1,2	A,C,F,H,O	112675512(-)	`TGCACG/ATACTT`	2	--	ng5¹ ese³		9		MN NA EU EA WA	926
	rs955888^1,2	A,C,F,H,O	112677483(-)	`TCTTGG/TAGGAT`	2	--	ut3¹ ese³		14		MN NA EU EA WA	1346
	rs13094^1,2	A,C,F,H	112676174(+)	`CCTTTT/GCATGA`	2	--	ut3¹ ese³		5		MN EU EA WA	602
	rs551517^1,2	A,C,F,H	112676614(-)	`AAAATG/ACAGAA`	2	--	ut3¹ ese³		9		MN EU EA WA	1020
--	rs15991^1,2	A,C,F,H	112676200(-)	`GAAATG/ATCATC`	2	--	ut3¹		6		MN EU EA WA	792
	rs1043128^1,2	A,C,F,H	112675750(-)	`TGTTGT/CCCAGG`	2	--	ng5¹		4		EU EA WA	412
	rs10980701^1,2	A,C,F,H	112841262(+)	`TAAACC/GAAAGC`	2	--	ng3¹		4		EU EA WA	418
	rs10980702^1,2	A,C	112841526(+)	`CTCACA/CACACC`	2	--	ng3¹		0	--	--	--	--
	rs1061548^1,2	F,H	112676307(-)	`ATTTTC/GATTAT`	2	--	ut3¹		3		MN EU WA	392
--	rs7858454^1,2	C	112840263(+)	`gccccC/Tttacc`	2	--	ng3¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for LPAR1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 602282

10 Novoseek disease relationships for LPAR1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
ovarian cancer	47.40	6	18461672 (2), 19001604 (1), 19116446 (1), 11353786 (1) (see all 5)
metastasis	28.74	7	18089805 (4), 11291053 (1), 10632375 (1), 17671192 (1)
cancer	27.41	16	19025891 (2), 15220934 (2), 14744855 (2), 9525886 (1) (see all 10)
breast carcinoma	21.30	1	18089805 (1)
osteosarcoma	19.92	1	10961347 (1)
tumors	12.02	8	19001604 (2), 18089805 (2), 19025891 (1), 11353786 (1) (see all 6)
colon cancer	8.39	2	15728708 (1), 12670925 (1)
breast cancer	7.30	3	10493533 (1), 18089805 (1), 16109476 (1)
gastric cancer	6.80	3	15530853 (1), 16353194 (1), 18701480 (1)
prostate cancer	2.27	4	16809448 (2), 19025891 (1), 17531530 (1)

About this table

Human Gene Mutation Database: LPAR1
Human Genome Epidemiology Navigator: LPAR1 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/122 PubMed articles for LPAR1 gene (see all 122 ):

Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid. (PubMed id 9070858)^{1, 2, 3, 4} An S....Goetzl E.J. (1997)
Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex. (PubMed id 8922387)^{1, 2, 3} Hecht J.H....Chun J. (1996)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Lysophosphatidic acid receptors. (PubMed id 11093753)^{3, 4} Contos J.J.A.... Chun J. (2000)
Lysophosphatidic acid: G-protein signalling and cellular responses. (PubMed id 9069262)^{3, 4} Moolenaar W.H.... Zondag G.C.M. (1997)
Integrin signalling regulates the nuclear localization and function of the lysophosphatidic acid receptor-1 (LPA1) in mammalian cells. (PubMed id 16716145)^{1, 3} Waters C.M....Pyne N.J. (2006)
Nm23-H1 suppresses metastasis by inhibiting expression of the lysophosphatidic acid receptor EDG2. (PubMed id 18089805)^{1, 3} Horak C.E....Steeg P.S. (2007)
Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization. (PubMed id 9804623)^{1, 3} An S....Goetzl E.J. (1998)
Lysophosphatidic acid stimulates the proliferation and motility of malignant pleural mesothelioma cells through lysophosphatidic acid receptors, LPA1 and LPA2. (PubMed id 18754873)^{1, 3} Yamada T....Sone S. (2008)
Expression and function of lysophosphatidic acid LPA1 receptor in prostate cancer cells. (PubMed id 16809448)^{1, 3} Guo R....Daaka Y. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 1902	HGNC: 3166	AceView: EDG2	Ensembl:ENSG00000198121	euGenes: HUgn1902
ECgene: LPAR1	H-InvDB: LPAR1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for LPAR1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for LPAR1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for LPAR1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for LPAR1		Antibodies for LPAR1
	Explore super-pooled esiRNAs		Proteins for LPAR1
	Lentivirus-delivered shRNAs for LPAR1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (LPAR1)
	Antibodies (LPAR1)
	Chimera RNAi (LPAR1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (EDG2)
	Antibodies (EDG2)

Search OriGene for LPAR1

Search Tocris compounds for LPAR1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for LPAR1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
LPAR1 Gene at Home site.
Version 2.41.1
server5.xennexinc.com

LPAR1 Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for LPAR1

Summaries
for LPAR1

Genomic Location
for LPAR1

Proteins
for LPAR1

Protein Domains/
Families
for LPAR1

Gene Function
for LPAR1

Pathways & Interactions
for LPAR1

Drugs & Compounds
for LPAR1

Transcripts
for LPAR1

Expression
for LPAR1

Orthologs
for LPAR1

Paralogs
for LPAR1

SNPs/Variants
for LPAR1

Disorders & Mutations
for LPAR1

Medical News
for LPAR1

Publications
for LPAR1

Search for LPAR1

Genome Databases showing LPAR1

Other Databases showing LPAR1

Specialized Databases showing LPAR1

Licensable Technologies
for LPAR1

Services
for LPAR1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

LPAR1 Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor LPAR1

Summariesfor LPAR1

Genomic Locationfor LPAR1

Proteinsfor LPAR1

Protein Domains/Familiesfor LPAR1

Gene Functionfor LPAR1

Pathways & Interactionsfor LPAR1

Drugs & Compoundsfor LPAR1

Transcriptsfor LPAR1

Expression for LPAR1

Orthologsfor LPAR1

Paralogsfor LPAR1

SNPs/Variantsfor LPAR1

Disorders & Mutationsfor LPAR1

Medical Newsfor LPAR1

Publicationsfor LPAR1

Search for LPAR1

Genome Databases showing LPAR1

Other Databases showing LPAR1

Specialized Databases showing LPAR1

Licensable Technologiesfor LPAR1

Servicesfor LPAR1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for LPAR1

Summaries
for LPAR1

Genomic Location
for LPAR1

Proteins
for LPAR1

Protein Domains/
Families
for LPAR1

Gene Function
for LPAR1

Pathways & Interactions
for LPAR1

Drugs & Compounds
for LPAR1

Transcripts
for LPAR1

Expression
for LPAR1

Orthologs
for LPAR1

Paralogs
for LPAR1

SNPs/Variants
for LPAR1

Disorders & Mutations
for LPAR1

Medical News
for LPAR1

Publications
for LPAR1

Licensable Technologies
for LPAR1

Services
for LPAR1