V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

S1PR1 Gene

protein-coding GIFtS: 57

GC01P101475

sphingosine-1-phosphate receptor 1
(Previous names: endothelial differentiation, sphingolipid G-protein-coupled receptor, 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: EDG1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CHEDG1 ^², ³
D1S3362 ^¹, ²
ECGF1 ^²
EDG-1 ^²
EDG1 ^², ³, ⁵
FLJ58121 ^²
OTTHUMP00000012525 ^²
S1P1 ^², ³, ⁵
edg-1 ^¹

Descriptions
Endothelial differentiation G-protein coupled receptor 1 ^³
G protein-coupled sphingolipid receptor ^²
S1P receptor 1 ^³
S1P receptor Edg-1 ^³
Sphingosine 1-phosphate receptor Edg-1 ^³
endothelial differentiation, sphingolipid G-protein-coupled receptor, 1 ^¹, ²
sphingosine 1-phosphate receptor EDG1 ^²
sphingosine-1-phosphate receptor 1 ^²

External Ids
HGNC: 3165¹
Entrez Gene: 1901²
UniProtKB: P21453³
Ensembl: ENSG00000170989⁷

Search outside databases for aliases for S1PR1 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for S1PR1:

The protein encoded by this gene is structurally similar to G protein-coupled receptors and is

highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high

affinity and high specificity, and suggested to be involved in the processes that regulate the

differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion.

[provided by RefSeq]

UniProtKB/Swiss-Prot: S1PR1_HUMAN, P21453

Function: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive

lysophospholipid that elicits diverse physiological effect on most types of cells and tissues.

This inducible epithelial cell G-protein-coupled receptor may be involved in the processes that

regulate the differentiation of endothelial cells. Seems to be coupled to the G(i) subclass of

heteromeric G proteins

Gene Wiki entry for S1PR1 (EDG1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p21 Ensembl cytogenetic band: 1p21.2 HGNC cytogenetic band: 1p21

S1PR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P101475: (about GC identifiers)

Start:	101,475,043 bp from pter
End:	101,479,662 bp from pter
Size:	4,620 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000001.9 NT_032977.8

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: S1PR1_HUMAN, P21453 (See protein sequence)

Recommended Name: Sphingosine 1-phosphate receptor 1

Size: 382 amino acids; 42811 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Secondary accessions: Q9BYY4 Q9NYN8

Post-translational modifications:

S1P-induced endothelial cell migration requires the PKB/AKT1-mediated phosphorylation of the third

intracellular loop at the Thr-236 residue¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001391.2

ENSEMBL proteins:

ENSP00000305416

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant S1PR1 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (EDG1)
	Human Recombinant Proteins from Abnova (S1PR1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	8626678
GO:0016021	integral to membrane	IEA	--

About this table

Antibodies for S1PR1:

	Invitrogen Antibodies for S1PR1
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for S1PR1
	R&D Systems Antibodies for S1PR1 (EDG-1)
	Antibodies from Abcam (EDG1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (S1PR1)
	Novus Biologicals Antibodies for S1PR1

Assays for S1PR1:

	Invitrogen Assays for S1PR1
	Millipore Kits and Assays for the Analysis of S1PR1
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P21453

ProtoNet protein and cluster: P21453

2 Blocks protein families:

IPB000987 EDG1 orphan receptor signature

IPB004061 Sphingosine 1-phosphate receptor family signature

UniProtKB/Swiss-Prot: S1PR1_HUMAN, P21453

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (S1PR1)
		Millipore RNAi Products for the Analysis of S1PR1 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (S1PR1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001400

Applied Biosystems Silencer® siRNAs for S1PR1

Sigma-Aldrich siRNA and siRNA Panels for S1PR1

Sigma-Aldrich shRNA Panels and shRNA for S1PR1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for S1PR1
		Millipore Clones for the Expression of S1PR1

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001400
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001400
untagged cDNA clone in CMV expression vector: NM_001400

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001400

UniProtKB/Swiss-Prot: S1PR1_HUMAN, P21453

Function: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive

lysophospholipid that elicits diverse physiological effect on most types of cells and tissues.

This inducible epithelial cell G-protein-coupled receptor may be involved in the processes that

regulate the differentiation of endothelial cells. Seems to be coupled to the G(i) subclass of

heteromeric G proteins

Induction: By the tumor promoter phorbol 12-myristate 13-acetate (PME) in the presence of

cycloheximide

9 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for S1pr1):

	cellular	embryogenesis	homeostasis/metabolism	lethality-prenatal/perinatal
limbs/digits/tail	muscle	nervous system	normal

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001619	lysosphingolipid and lysophosphatidic acid receptor activity	IEA	--
GO:0004872	receptor activity	IEA	--
GO:0004930	G-protein coupled receptor activity	TAS	8626678
GO:0046625	sphingolipid binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for S1PR1 (Your Favorite Gene powered by Ingenuity)

Ceramide Signaling
Human Embryonic Stem Cell Pluripotency

GeneDecks S1PR1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for S1PR1

5/49 Interacting proteins for S1PR1 (ENSP00000305416³) via UniProtKB, MINT, and/or STRING (see all 49 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AKT1	ENSP00000270202³	STRING (score=.986)
PDGFRB	ENSP00000261799³	STRING (score=.983)
MBTPS1	ENSP00000344223³	STRING (score=.967)
MAPK3	ENSP00000263025³	STRING (score=.966)
GNAI3	ENSP00000358867³	STRING (score=.964)

About this table

5/16 Gene Ontology (GO) biological process terms (links to tree view) (see all 16 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001525	angiogenesis	IEA	--
GO:0007165	signal transduction	IEA	--
GO:0007186	G-protein coupled receptor protein signaling pathway	TAS	8626678
GO:0007193	inhibition of adenylate cyclase activity by G-protein signaling	IEA	--
GO:0007420	brain development	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for S1PR1:

Mixed Agonist/Antagonist Antagonist

Compounds for S1PR1 available from Tocris Bioscience

Compound	Action	CAS number
SEW 2871	Cell-permeable, selective S1P1 receptor agonist	[256414-75-2]
Sphingosine-1-phosphate	Endogenous agonist at S1P1-5	[26993-30-6]

About this table

10/13 Novoseek chemical compound relationships for S1PR1 gene (see all 13 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
dhs-1-p	90.22	4	11146117 (2), 9660876 (1)
sphingosylphosphorylcholine	86.36	5	10833459 (1), 10381367 (1), 9726638 (1)
sphingosine	85.92	12	11726541 (2), 11230698 (2), 18474015 (1), 18644866 (1) (see all 7)
lysophospholipid	84.90	4	11604399 (1), 16830220 (1), 16990586 (1)
lipid	42.53	7	10794715 (2), 17156449 (1), 18381082 (1), 16963454 (1) (see all 5)
phosphatidylinositol	25.67	2	15334188 (1), 17403093 (1)
calcium	22.57	13	9765227 (3), 10383399 (1), 9480864 (1), 9660876 (1) (see all 7)
tyrosine	14.11	3	9660876 (1), 18834877 (1), 11544274 (1)
thymidine	4.82	1	15625079 (1)
nitric oxide	3.18	1	10921915 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (S1PR1)
		Millipore RNAi Products for the Analysis of S1PR1 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (S1PR1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001400

Sigma-Aldrich siRNA and siRNA Panels for S1PR1

Sigma-Aldrich shRNA Panels and shRNA for S1PR1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001400

REFSEQ mRNAs for S1PR1 gene:

NM_001400.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001400

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001400
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001400
                                 untagged cDNA clone in CMV expression vector: NM_001400

Additional cDNA sequence:

AF022137.1 AF233365.1 AK297005.1 AK312493.1 BC018650.1 CR541786.1 CR542269.1

9 DOTS entries:

DT.112585 DT.110351 DT.95283317 DT.100662216 DT.100775720 DT.121387197 DT.95137763 DT.95137764

DT.95122743

24/105 AceView cDNA sequences (see all 105 ):

BP345893 BP344454 AW515813 BM354114 AW827198 BU677564 BQ003555 AF233365

BQ723639 CK820076 BU681185 CK429916 BM021114 AA370448 BG251038 CR541786

F01623 CR542269 BC018650 AA304390 BX104139 AI566829 AI636061 BE710296

Unigene Cluster for S1PR1:

Sphingosine-1-phosphate receptor 1

Hs.154210 [show with all ESTs]

Unigene Representative Sequence: NM_001400

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000305352

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

S1PR1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for S1PR1

¹ / ²

3 probe-sets matching S1PR1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
587_at²	U95-A	1	1.00	1.00	1.00	1.00	--	--	--	--	--
204642_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
204642_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.154210
UniProtKB/Swiss-Prot: S1PR1_HUMAN, P21453
Tissue specificity: Endothelial cells, and to a lesser extent, in vascular smooth muscle cells,
fibroblasts, melanocytes, and cells of epithelioid origin

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for S1PR1 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	S1PR1¹	--	sphingosine-1-phosphate receptor 1	90.75(n) 95.03(a)	490138 XM_547259.2 XP_547259.2
chimpanzee (Pan troglodytes)	S1PR1¹	--	sphingosine-1-phosphate receptor 1	99.48(n) 99.48(a)	457063 XM_513598.2 XP_513598.1
cow (Bos taurus)	S1PR1¹	--	sphingosine-1-phosphate receptor 1	92.23(n) 94.24(a)	281135 NM_001013585.3 NP_001013603.2
rat (Rattus norvegicus)	S1pr1¹	--	sphingosine-1-phosphate receptor 1	87.77(n) 93.93(a)	29733 NM_017301.2 NP_058997.1
mouse (Mus musculus)	S1pr1^{1, 5}	3⁵	sphingosine-1-phosphate receptor 1^{1, 5}	88.13(n)¹ 94.24(a)¹	13609¹ NM_007901.4¹ NP_031927.2¹ AA145076⁵ AF108019⁵ (see all 15)

About this table Species with no ortholog for S1PR1

ENSEMBL Gene Tree for S1PR1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for S1PR1 gene

S1PR3² S1PR2² S1PR5²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/12 NCBI SNPs in S1PR1 are shown (see all 12 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 51)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs12090529^1,2	C,F,H	101479714(+)	`TGGATT/CGTGTA`	1	--	ng3¹		12		EU EA WA NA	1056
	rs2295337^1,2	F,H	101479718(+)	`TTGTGT/CAGCTC`	1	--	ng3¹		5		EA EU WA	1886
	rs12141562^1,2	H	101473326(+)	`ccttaG/Attgtc`	1	--	ng5¹ tfbs³		4		EU EA WA	418
--	rs11588489^1,2	C	101480158(+)	`TTTTTG/TTTTTT`	1	--	ng3¹		0	--	--	--	--
	rs4987253^1,2	H	101479428(+)	`GGGAAC/TGCCAG`	1	--	ut3¹ ese³		4		EU EA WA	420
	rs1056841^1,2	--	101479227(+)	`AGAATC/GTTGTG`	1	--	ut3¹		0	--	--	--	--
--	rs60371231^1,2	--	101473136(+)	`ACTTGA/TACAGT`	1	--	ng5¹		0	--	--	--	--
--	rs35541620^1,2	--	101480150(+)	`ATGTG-/TTTTTT`	1	--	ng3¹		0	--	--	--	--
--	rs34957251^1,2	--	101480156(+)	`TTTTT-/GTTTTT`	1	--	ng3¹		0	--	--	--	--
	rs1056840^1,2	--	101479198(+)	`TCTTTC/GGCACT`	1	--	ut3¹ ese³		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for S1PR1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 601974

10 Novoseek disease relationships for S1PR1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
glioblastoma	31.53	1	12175535 (1)
glioma	28.17	3	11146117 (3)
autoimmunity	27.64	1	15578083 (1)
inflammation	24.22	2	18474015 (1)
neovascularization	14.58	1	15334188 (1)
sepsis	2.92	3	15710622 (1), 19278594 (1)
breast cancer	0.00	1	10493533 (1)
tumors	0.00	1	17203465 (1)
ovarian cancer	0.00	3	17349972 (1), 10818454 (1)
vascular diseases	0.00	2	11557736 (1)

About this table

Human Genome Epidemiology Navigator: S1PR1 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/176 PubMed articles for S1PR1 gene (see all 176 ):

An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein- coupled receptors. (PubMed id 2160972)^{1, 2, 3, 4} Hla T. and Maciag T. (1990)
Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1. (PubMed id 9488656)^{1, 2, 3, 4} Lee M.J....Hla T. (1998)
Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility. (PubMed id 11230698)^{1, 3, 4} Hobson J.P.... Spiegel S. (2001)
The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway. (PubMed id 8626678)^{1, 3, 4} Lee M.-J.... Hla T. (1996)
Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5. (PubMed id 10383399)^{1, 3, 4} Ancellin N. and Hla T. (1999)
Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis. (PubMed id 11583630)^{1, 3, 4} Lee M.-J.... Hla T. (2001)
Identification of Edg1 receptor residues that recognize sphingosine 1-phosphate. (PubMed id 10982820)^{3, 4} Parrill A.L.... Tigyi G. (2000)
Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids. (PubMed id 9409733)^{3, 4} An S....Goetzl E.J. (1997)
Agonist-modulated targeting of the EDG-1 receptor to plasmalemmal caveolae. eNOS activation by sphingosine 1-phosphate and the role of caveolin-1 in sphingolipid signal transduction. (PubMed id 10921915)^{1, 3} Igarashi J. and Michel T. (2000)
Dual regulation of EDG1/S1P(1) receptor phosphorylation and internalization by protein kinase C and G-protein-coupled receptor kinase 2. (PubMed id 11741892)^{1, 3} Watterson K.R....Palmer T.M. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 1901	HGNC: 3165	AceView: EDG1	Ensembl:ENSG00000170989	euGenes: HUgn1901
ECgene: S1PR1	H-InvDB: S1PR1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for S1PR1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for S1PR1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for S1PR1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for S1PR1		Antibodies for S1PR1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for S1PR1		Small molecules for S1PR1
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (S1PR1)
	Antibodies (S1PR1)
	Chimera RNAi (S1PR1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (EDG1)
	Antibodies (EDG1)

Search OriGene for S1PR1

Tocris compounds for S1PR1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for S1PR1

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
S1PR1 Gene at Home site.
Version 2.41.1
server4.xennexinc.com

S1PR1 Gene

protein-coding GIFtS: 57

Aliases &
Descriptions
for S1PR1

Summaries
for S1PR1

Genomic Location
for S1PR1

Proteins
for S1PR1

Protein Domains/
Families
for S1PR1

Gene Function
for S1PR1

Pathways & Interactions
for S1PR1

Drugs & Compounds
for S1PR1

Transcripts
for S1PR1

Expression
for S1PR1

Orthologs
for S1PR1

Paralogs
for S1PR1

SNPs/Variants
for S1PR1

Disorders & Mutations
for S1PR1

Medical News
for S1PR1

Publications
for S1PR1

Search for S1PR1

Genome Databases showing S1PR1

Other Databases showing S1PR1

Specialized Databases showing S1PR1

Licensable Technologies
for S1PR1

Services
for S1PR1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

S1PR1 Gene

protein-coding GIFtS: 57

Aliases & Descriptionsfor S1PR1

Summariesfor S1PR1

Genomic Locationfor S1PR1

Proteinsfor S1PR1

Protein Domains/Familiesfor S1PR1

Gene Functionfor S1PR1

Pathways & Interactionsfor S1PR1

Drugs & Compoundsfor S1PR1

Transcriptsfor S1PR1

Expression for S1PR1

Orthologsfor S1PR1

Paralogsfor S1PR1

SNPs/Variantsfor S1PR1

Disorders & Mutationsfor S1PR1

Medical Newsfor S1PR1

Publicationsfor S1PR1

Search for S1PR1

Genome Databases showing S1PR1

Other Databases showing S1PR1

Specialized Databases showing S1PR1

Licensable Technologiesfor S1PR1

Servicesfor S1PR1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for S1PR1

Summaries
for S1PR1

Genomic Location
for S1PR1

Proteins
for S1PR1

Protein Domains/
Families
for S1PR1

Gene Function
for S1PR1

Pathways & Interactions
for S1PR1

Drugs & Compounds
for S1PR1

Transcripts
for S1PR1

Expression
for S1PR1

Orthologs
for S1PR1

Paralogs
for S1PR1

SNPs/Variants
for S1PR1

Disorders & Mutations
for S1PR1

Medical News
for S1PR1

Publications
for S1PR1

Licensable Technologies
for S1PR1

Services
for S1PR1