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Aliases for EDF1 Gene

Aliases for EDF1 Gene

  • Endothelial Differentiation-Related Factor 1 2 3
  • EDF-1 3 4
  • MBF1 3 4
  • Multiprotein Bridging Factor-1 2
  • Multiprotein Bridging Factor 1 3
  • Multiprotein-Bridging Factor 1 4

External Ids for EDF1 Gene

Previous GeneCards Identifiers for EDF1 Gene

  • GC09M130979
  • GC09M131446
  • GC09M133197
  • GC09M135113
  • GC09M137032
  • GC09M138876
  • GC09M139756
  • GC09M109215

Summaries for EDF1 Gene

Entrez Gene Summary for EDF1 Gene

  • This gene encodes a protein that may regulate endothelial cell differentiation, lipid metabolism, and hormone-induced cardiomyocyte hypertrophy. The encoded protein has also been found to act as a transcriptional coactivator by interconnecting the general transcription factor TATA element-binding protein (TBP) and gene-specific activators. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for EDF1 Gene

EDF1 (Endothelial Differentiation-Related Factor 1) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription coactivator activity.

UniProtKB/Swiss-Prot for EDF1 Gene

  • Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism.

Gene Wiki entry for EDF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EDF1 Gene

Genomics for EDF1 Gene

Regulatory Elements for EDF1 Gene

Genomic Location for EDF1 Gene

Start:
136,862,114 bp from pter
End:
136,866,336 bp from pter
Size:
4,223 bases
Orientation:
Minus strand

Genomic View for EDF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EDF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EDF1 Gene

Proteins for EDF1 Gene

  • Protein details for EDF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60869-EDF1_HUMAN
    Recommended name:
    Endothelial differentiation-related factor 1
    Protein Accession:
    O60869
    Secondary Accessions:
    • Q5T5T2
    • Q9UIM1

    Protein attributes for EDF1 Gene

    Size:
    148 amino acids
    Molecular mass:
    16369 Da
    Quaternary structure:
    • Interacts with TBP and the transcription factor IID (TFIID) complex, NR5A2, NR1H3 and PPARG. Interaction with TBP is regulated by phosphorylation. Binds NR5A1, ATF1, FOS and JUN via their conserved basic region. Binding to calmodulin is regulated by calcium and phosphorylation of the IQ motif.
    SequenceCaution:
    • Sequence=CAI12698.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for EDF1 Gene

    Alternative splice isoforms for EDF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EDF1 Gene

Proteomics data for EDF1 Gene at MOPED

Post-translational modifications for EDF1 Gene

Other Protein References for EDF1 Gene

No data available for DME Specific Peptides for EDF1 Gene

Domains for EDF1 Gene

Protein Domains for EDF1 Gene

Suggested Antigen Peptide Sequences for EDF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60869

UniProtKB/Swiss-Prot:

EDF1_HUMAN :
  • O60869
Domain:
  • The IQ motif, which is involved in calmodulin binding, overlaps with the binding domain for nuclear receptors and transcription factors. Its phosphorylation probably allows a switch between the two activities of the protein (By similarity).
  • Contains 1 HTH cro/C1-type DNA-binding domain.
genes like me logo Genes that share domains with EDF1: view

No data available for Gene Families for EDF1 Gene

Function for EDF1 Gene

Molecular function for EDF1 Gene

UniProtKB/Swiss-Prot Function: Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism.
UniProtKB/Swiss-Prot Induction: Down-regulated by HIV-1 Tat or phorbol ester (TPA) treatment in endothelial cells (at mRNA and protein levels).

Gene Ontology (GO) - Molecular Function for EDF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0003700 NOT sequence-specific DNA binding transcription factor activity IMP 12040021
GO:0003713 transcription coactivator activity IMP 10567391
GO:0004402 NOT histone acetyltransferase activity IDA 12040021
GO:0005515 protein binding IPI 10567391
genes like me logo Genes that share ontologies with EDF1: view
genes like me logo Genes that share phenotypes with EDF1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EDF1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for EDF1 Gene

Localization for EDF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EDF1 Gene

Cytoplasm. Nucleus. Note=Also nuclear upon binding to NR5A1 and treatment of cells with TPA or forskolin.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EDF1 Gene COMPARTMENTS Subcellular localization image for EDF1 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for EDF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular TAS 9813014
GO:0005634 nucleus NAS 8164657
GO:0005669 colocalizes_with transcription factor TFIID complex IDA 12040021
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IMP 10567391
genes like me logo Genes that share ontologies with EDF1: view

Pathways for EDF1 Gene

SuperPathways for EDF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for EDF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated TAS 12040021
GO:0007275 multicellular organismal development IEA --
GO:0019216 regulation of lipid metabolic process TAS 12040021
GO:0043388 positive regulation of DNA binding IDA 10567391
genes like me logo Genes that share ontologies with EDF1: view

No data available for Pathways by source for EDF1 Gene

Compounds for EDF1 Gene

(1) HMDB Compounds for EDF1 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(3) Novoseek inferred chemical compound relationships for EDF1 Gene

Compound -log(P) Hits PubMed IDs
leucine 35.9 1
h2o2 11.5 1
nitric oxide 0 1
genes like me logo Genes that share compounds with EDF1: view

Transcripts for EDF1 Gene

Unigene Clusters for EDF1 Gene

Endothelial differentiation-related factor 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EDF1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EDF1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6
SP1: - -
SP2: -
SP3:

Relevant External Links for EDF1 Gene

GeneLoc Exon Structure for
EDF1
ECgene alternative splicing isoforms for
EDF1

Expression for EDF1 Gene

mRNA expression in normal human tissues for EDF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EDF1 Gene

SOURCE GeneReport for Unigene cluster for EDF1 Gene Hs.174050

mRNA Expression by UniProt/SwissProt for EDF1 Gene

O60869-EDF1_HUMAN
Tissue specificity: Expressed in brain, liver, lung, kidney and heart (at protein level). Ubiquitously expressed. More abundant in heart, pancreas, liver, intestine and adipose tissues.
genes like me logo Genes that share expressions with EDF1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for EDF1 Gene

Orthologs for EDF1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EDF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EDF1 35
  • 99.73 (n)
  • 100 (a)
EDF1 36
  • 86 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EDF1 35
  • 89.86 (n)
  • 100 (a)
EDF1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EDF1 35
  • 90.99 (n)
  • 100 (a)
EDF1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Edf1 35
  • 88.96 (n)
  • 98.65 (a)
Edf1 16
Edf1 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EDF1 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EDF1 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Edf1 35
  • 88.74 (n)
  • 98.65 (a)
chicken
(Gallus gallus)
Aves EDF1 35
  • 80.63 (n)
  • 93.24 (a)
EDF1 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EDF1 36
  • 80 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5866 35
tropical clawed frog
(Silurana tropicalis)
Amphibia edf1 35
  • 81.46 (n)
  • 91.55 (a)
Str.8917 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1654 35
zebrafish
(Danio rerio)
Actinopterygii edf1 35
  • 77.78 (n)
  • 85.82 (a)
edf1 36
  • 76 (a)
OneToOne
zgc73192 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004990 35
  • 63.36 (n)
  • 65.96 (a)
fruit fly
(Drosophila melanogaster)
Insecta mbf1 35
  • 66.18 (n)
  • 65.94 (a)
mbf1 36
  • 58 (a)
OneToOne
mbf1 37
  • 65 (a)
worm
(Caenorhabditis elegans)
Secernentea mbf-1 35
  • 55.33 (n)
  • 55.78 (a)
mbf-1 36
  • 46 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR526C 35
  • 53.7 (n)
  • 49.31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MBF1 35
  • 50.72 (n)
  • 47.1 (a)
MBF1 36
  • 39 (a)
OneToOne
MBF1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F25014g 35
  • 52.58 (n)
  • 49.3 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons MBF1B 35
  • 57.44 (n)
  • 56.15 (a)
rice
(Oryza sativa)
Liliopsida Os08g0366100 35
  • 57.44 (n)
  • 55.38 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC83.17 35
  • 50.23 (n)
  • 52.08 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1189 35
Species with no ortholog for EDF1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EDF1 Gene

ENSEMBL:
Gene Tree for EDF1 (if available)
TreeFam:
Gene Tree for EDF1 (if available)

Paralogs for EDF1 Gene

No data available for Paralogs for EDF1 Gene

Variants for EDF1 Gene

Sequence variations from dbSNP and Humsavar for EDF1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs945385 -- 136,862,025(-) AGTAG(C/T)GGTTG downstream-variant-500B
rs1058974 -- 136,862,420(-) GGGAA(A/G)ATGTT utr-variant-3-prime, intron-variant, downstream-variant-500B
rs4880147 -- 136,866,722(+) CGCTC(C/G)AGGAC upstream-variant-2KB
rs4880148 -- 136,866,812(+) GCTCT(A/G)TCGCC upstream-variant-2KB
rs7025238 -- 136,865,979(+) CCCCT(A/G)TCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EDF1 Gene

Variant ID Type Subtype PubMed ID
dgv2426e1 CNV Complex 17122850
nsv469918 CNV Loss 18288195
nsv894387 CNV Gain 21882294
dgv2427e1 CNV Complex 17122850
esv2422220 CNV Deletion 17116639
dgv8408n71 CNV Loss 21882294
dgv8412n71 CNV Loss 21882294
dgv8414n71 CNV Loss 21882294
dgv8415n71 CNV Loss 21882294
dgv8416n71 CNV Loss 21882294
nsv818738 CNV Gain 17921354
dgv8417n71 CNV Loss 21882294
dgv8418n71 CNV Loss 21882294
dgv8419n71 CNV Loss 21882294
nsv524322 CNV Loss 19592680
nsv894469 CNV Loss 21882294
dgv8420n71 CNV Loss 21882294
nsv894483 CNV Loss 21882294
nsv894488 CNV Loss 21882294
nsv8582 CNV Gain 18304495

Relevant External Links for EDF1 Gene

HapMap Linkage Disequilibrium report
EDF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EDF1 Gene

Disorders for EDF1 Gene

(1) University of Copenhagen DISEASES for EDF1 Gene

genes like me logo Genes that share disorders with EDF1: view

No data available for UniProtKB/Swiss-Prot for EDF1 Gene

Publications for EDF1 Gene

  1. EDF-1, a novel gene product down-regulated in human endothelial cell differentiation. (PMID: 9813014) Dragoni I. … Maier J.A.M. (J. Biol. Chem. 1998) 2 3 4 23
  2. The dual role of endothelial differentiation-related factor-1 in the cytosol and nucleus: modulation by protein kinase A. (PMID: 15112053) Ballabio E. … Maier J.A.M. (Cell. Mol. Life Sci. 2004) 2 3 4 23
  3. The role of human MBF1 as a transcriptional coactivator. (PMID: 10567391) Kabe Y. … Handa H. (J. Biol. Chem. 1999) 3 4 23
  4. Interaction between endothelial differentiation-related factor-1 and calmodulin in vitro and in vivo. (PMID: 10816571) Mariotti M. … Maier J.A.M. (J. Biol. Chem. 2000) 3 4 23
  5. Identification of the core domain and the secondary structure of the transcriptional coactivator MBF1. (PMID: 10469174) Ozaki J. … Shirakawa M. (Genes Cells 1999) 3 23

Products for EDF1 Gene

Sources for EDF1 Gene

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