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EDF1 Gene

protein-coding   GIFtS: 58
GCID: GC09M139756

Endothelial Differentiation-Related Factor 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Endothelial Differentiation-Related Factor 11 2
EDF-12 3
MBF12 3
Multiprotein Bridging Factor-11
Multiprotein Bridging Factor 12
Multiprotein-Bridging Factor 13

External Ids:    HGNC: 31641   Entrez Gene: 87212   Ensembl: ENSG000001072237   OMIM: 6051075   UniProtKB: O608693   

Export aliases for EDF1 gene to outside databases

Previous GC identifers: GC09M130979 GC09M131446 GC09M133197 GC09M135113 GC09M137032 GC09M138876 GC09M109215


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for EDF1 Gene:
This gene encodes a protein that may regulate endothelial cell differentiation, lipid metabolism, and
hormone-induced cardiomyocyte hypertrophy. The encoded protein has also been found to act as a transcriptional
coactivator by interconnecting the general transcription factor TATA element-binding protein (TBP) and
gene-specific activators. Alternate splicing results in multiple transcript variants. (provided by RefSeq, Jul
2013)

GeneCards Summary for EDF1 Gene:
EDF1 (endothelial differentiation-related factor 1) is a protein-coding gene. Diseases associated with EDF1 include endotheliitis, and sinusitis. GO annotations related to this gene include transcription coactivator activity and sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot: EDF1_HUMAN, O60869
Function: Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional
activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase
activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation,
hormone-induced cardiomyocytes hypertrophy and lipid metabolism

Gene Wiki entry for EDF1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NC_018920.2  NT_008470.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the EDF1 gene promoter:
         AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEDF1 promoter sequence
   Search Chromatin IP Primers for EDF1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EDF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.3   Ensembl cytogenetic band:  9q34.3   HGNC cytogenetic band: 9q34.3

EDF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EDF1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M139756:  view genomic region     (about GC identifiers)

Start:
139,756,571 bp from pter      End:
139,760,738 bp from pter
Size:
4,168 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: EDF1_HUMAN, O60869 (See protein sequence)
Recommended Name: Endothelial differentiation-related factor 1  
Size: 148 amino acids; 16369 Da
Subunit: Interacts with TBP and the transcription factor IID (TFIID) complex, NR5A2, NR1H3 and PPARG. Interaction
with TBP is regulated by phosphorylation. Binds NR5A1, ATF1, FOS and JUN via their conserved basic region.
Binding to calmodulin is regulated by calcium and phosphorylation of the IQ motif
Developmental stage: Expressed in fetal tissues. More abundant in kidney
Sequence caution: Sequence=CAI12698.1; Type=Erroneous gene model prediction;
1 PDB 3D structure from and Proteopedia for EDF1:
1X57 (3D)    
Secondary accessions: Q5T5T2 Q9UIM1
Alternative splicing: 2 isoforms:  O60869-1   O60869-2   

Explore the universe of human proteins at neXtProt for EDF1: NX_O60869

Explore proteomics data for EDF1 at MOPED

Post-translational modifications: 

  • Phosphorylated (by PKA and PKC)1
  • Ubiquitination2 at Lys25, Lys102, Lys143
  • Modification sites at PhosphoSitePlus

  • See EDF1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001268226.1  NP_001268227.1  NP_001268228.1  NP_003783.1  NP_694880.1  

    ENSEMBL proteins: 
     ENSP00000360712   ENSP00000224073   ENSP00000360711  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR010982 Lambda_DNA-bd_dom
     IPR001387 Cro/C1-type_HTH
     IPR013729 MBF1_N

    Graphical View of Domain Structure for InterPro Entry O60869

    ProtoNet protein and cluster: O60869

    1 Blocks protein domain: IPB013729 Multiprotein bridging factor 1

    UniProtKB/Swiss-Prot: EDF1_HUMAN, O60869
    Domain: The IQ motif, which is involved in calmodulin binding, overlaps with the binding domain for nuclear
    receptors and transcription factors. Its phosphorylation probably allows a switch between the two activities of
    the protein (By similarity)
    Similarity: Contains 1 HTH cro/C1-type DNA-binding domain


    EDF1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EDF1_HUMAN, O60869
    Function: Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional
    activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase
    activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation,
    hormone-induced cardiomyocytes hypertrophy and lipid metabolism
    Induction: Down-regulated by HIV-1 Tat or phorbol ester (TPA) treatment in endothelial cells (at mRNA and protein
    levels)

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700NOT sequence-specific DNA binding transcription factor activity IMP12040021
    GO:0003713transcription coactivator activity IMP10567391
    GO:0004402NOT histone acetyltransferase activity IDA12040021
    GO:0005515protein binding IPI10567391
         
    EDF1 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for EDF1:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Synthetic lethal with imatinib 

    Animal Models:
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    hsa-mir-296-3p (MIRT038500), hsa-mir-99b-5p (MIRT044209), hsa-mir-1 (MIRT023925), hsa-mir-18a-3p (MIRT040953), hsa-mir-149-5p (MIRT045491), hsa-mir-92b-3p (MIRT040630), hsa-mir-615-3p (MIRT039892)

    Block miRNA regulation of human, mouse, rat EDF1 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate EDF1:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EDF1_HUMAN, O60869: Cytoplasm. Nucleus. Note=Also nuclear upon binding to NR5A1 and treatment of cells with TPA
    or forskolin
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    mitochondrion2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular TAS9813014
    GO:0005634nucleus NAS8164657
    GO:0005669colocalizes with transcription factor TFIID complex IDA12040021
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IMP10567391

    EDF1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for EDF1
    Interactions:

        GeneGlobe Interaction Network for EDF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for EDF1 (O608691, 2, 3 ENSP000002240734) via UniProtKB, MINT, STRING, and/or I2D (see all 104)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TBPP202261, 3, ENSP000002303544EBI-781310,EBI-355371 I2D: score=4 STRING: ENSP00000230354
    NR5A2O004821, 3, ENSP000003563314EBI-781301,EBI-781320 I2D: score=3 STRING: ENSP00000356331
    NR1H3Q131331, 3EBI-781301,EBI-781356 I2D: score=3 
    MAPK6Q166592, 3MINT-8261032 I2D: score=2 
    CALM1P621583, ENSP000003494674I2D: score=3 STRING: ENSP00000349467
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated TAS12040021
    GO:0007275multicellular organismal development IEA--
    GO:0019216regulation of lipid metabolic process TAS12040021
    GO:0043388positive regulation of DNA binding IDA10567391

    EDF1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EDF1

    1 HMDB Compound for EDF1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    3 Novoseek inferred chemical compound relationships for EDF1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine 35.9 1 10567391 (1)
    h2o2 11.5 1 15306851 (1)
    nitric oxide 0 1 16055206 (1)



    EDF1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for EDF1 gene (5 alternative transcripts): 
    NM_001281297.1  NM_001281298.1  NM_001281299.1  NM_003792.3  NM_153200.2  

    Unigene Cluster for EDF1:

    Endothelial differentiation-related factor 1
    Hs.174050  [show with all ESTs]
    Unigene Representative Sequence: BE791300
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371649(uc022bpv.1) ENST00000224073(uc004cjt.1) ENST00000371648(uc004cju.1)

    miRNA
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    hsa-miR-214 hsa-miR-29a* hsa-miR-761
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    Inhib. RNA
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    Additional mRNA sequence: 

    AB002282.1 AB002283.2 BC015500.1 BT009863.1 CR541914.1 

    14 DOTS entries:

    DT.100885943  DT.455909  DT.92440628  DT.95366227  DT.95366228  DT.100802225  DT.92440626  DT.95366237 
    DT.100058114  DT.121158512  DT.121158524  DT.95366229  DT.95366234  DT.95366240 

    Selected AceView cDNA sequences (see all 360):

    AJ707618 BQ216014 BQ928916 BG761463 F25098 AI799798 AW162942 BG339619 
    BM800379 BE794038 AI682422 AW160438 NM_153200 AI399719 AA325420 BE220144 
    AI990962 D11976 AA598725 AI816085 BM760376 AA377914 BM914947 BM012455 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for EDF1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6
    SP1:                                      -     -         
    SP2:                                      -               
    SP3:                                                      


    ECgene alternative splicing isoforms for EDF1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EDF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAGGGTGAC
    EDF1 Expression
    About this image


    EDF1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
     
     Kidney (Urinary System)
             Metanephros
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Intermediate Mesoderm (Gastrulation Derivatives)
             Mesonephros
    EDF1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EDF1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.174050

    UniProtKB/Swiss-Prot: EDF1_HUMAN, O60869
    Tissue specificity: Expressed in brain, liver, lung, kidney and heart (at protein level). Ubiquitously expressed.
    More abundant in heart, pancreas, liver, intestine and adipose tissues

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EDF1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for EDF1 gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Edf11 , 5 endothelial differentiation-related factor 11, 5 88.96(n)1
    98.65(a)1
      2 (17.39 cM)5
    590221  NM_021519.11  NP_067494.11 
     255578475 
    chicken
    (Gallus gallus)
    Aves EDF11 endothelial differentiation-related factor 1 80.63(n)
    93.24(a)
      417286  NM_001006203.1  NP_001006203.1 
    lizard
    (Anolis carolinensis)
    Reptilia EDF16
    endothelial differentiation-related factor 1
    80(a)
    1 ↔ 1
    GL343888.1(21-5418)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.58662 Xenopus laevis transcribed sequence with moderate similarity more 80.51(n)    AW646501.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc731922 hypothetical protein MGC73192 81.43(n)   393718  BC059541.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mbf11 , 3 methyl-CpG binding3
    multiprotein bridging factor 11
    65(a)3
    66.18(n)1
    65.94(a)1
      73A93
    398421  NM_001275023.11  NP_001261952.11 
    worm
    (Caenorhabditis elegans)
    Secernentea mbf-11 mbf-1 55.33(n)
    55.78(a)
      178071  NM_069765.5  NP_502166.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MBF1(YOR298C-A)4
    MBF11
    Transcriptional coactivator that bridges the DNA-binding more4
    MBF11
    50.72(n)1
    47.1(a)1
      15(877685-877230)4
    8544741, 4  NP_014942.41  NP_014942.24 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MBF1B1 MBF1B 57.44(n)
    56.15(a)
      825037  NM_115730.3  NP_191427.1 
    rice
    (Oryza sativa)
    Liliopsida Os08g03661001 Os08g0366100 57.44(n)
    55.38(a)
      4345388  NM_001068182.1  NP_001061647.1 


    ENSEMBL Gene Tree for EDF1 (if available)
    TreeFam Gene Tree for EDF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for EDF1 (see all 172)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1825776581,2
    --109221839(+) GACACC/TGCACC 2 -- us2k10--------
    rs1881509331,2
    --139792911(+) CCCAGC/TGGAGG 1 -- ds50010--------
    rs1148111051,2
    C,F--139792912(+) CCAGCG/AGAGGG 1 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1166342531,2
    F--139792962(+) GTGCCG/CTGGGG 1 -- ds50011Minor allele frequency- C:0.01WA 118
    rs1917447011,2
    --139793052(+) CAGCCC/TACTCC 1 -- ds50010--------
    rs1430579611,2
    C--139793079(+) AAATTC/TACCAG 1 -- ds50010--------
    rs1461389311,2
    --139793158(+) AGGAAC/TTTTTC 1 -- ds50010--------
    rs9453851,2
    C,F,A,H--139793302(-) AGTAGT/CGGTTG 1 -- ds500134Minor allele frequency- C:0.19NS EA NA WA CSA 3093
    rs1122576721,2
    C--139793395(+) ACCCAG/TCGCTT 1 -- ds50010--------
    rs1997564491,2
    C--139793518(+) CCGGCG/CGAACG 1 -- ut311Minor allele frequency- C:0.00EU 593

    HapMap Linkage Disequilibrium report for EDF1 (139756571 - 139760738 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for EDF1 (see all 20):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422220CNV Deletion17116639
    nsv894483CNV Loss21882294
    dgv8414n71CNV Loss21882294
    dgv8416n71CNV Loss21882294
    dgv8420n71CNV Loss21882294
    dgv8418n71CNV Loss21882294
    nsv894469CNV Loss21882294
    nsv524322CNV Loss19592680
    dgv8415n71CNV Loss21882294
    dgv8417n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605107    OMIM disorders: --

    5 diseases for EDF1:    
    About MalaCards
    endotheliitis    sinusitis    eclampsia    malaria
    hiv-1

    1 disease from the University of Copenhagen DISEASES database for EDF1:
    Eclampsia

    EDF1 for disorders           About GeneDecksing


    Export disorders for EDF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EDF1 gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with EDF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The dual role of endothelial differentiation-related factor-1 in the cytosol and nucleus: modulation by protein kinase A. (PubMed id 15112053)1, 2, 3, 9 Ballabio E.... Maier J.A.M. (Cell. Mol. Life Sci. 2004)
    2. EDF-1, a novel gene product down-regulated in human endothelial cell differentiation. (PubMed id 9813014)1, 2, 3, 9 Dragoni I.... Maier J.A.M. (J. Biol. Chem. 1998)
    3. Interaction between endothelial differentiation-related factor-1 and calmodulin in vitro and in vivo. (PubMed id 10816571)1, 2, 9 Mariotti M.... Maier J.A.M. (J. Biol. Chem. 2000)
    4. The role of human MBF1 as a transcriptional coactivator. (PubMed id 10567391)1, 2, 9 Kabe Y.... Handa H. (J. Biol. Chem. 1999)
    5. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism. (PubMed id 12040021)1, 2 Brendel C.... Auwerx J. (Mol. Endocrinol. 2002)
    8. Identification of the core domain and the secondary structure of the transcriptional coactivator MBF1. (PubMed id 10469174)1, 9 Ozaki J....Shirakawa M. (amp 1999)
    9. Differential gene regulation by selective association of transcriptional coactivators and bZIP DNA-binding domains. (PubMed id 16880509)1, 9 Miotto B. and Struhl K. (Mol. Cell. Biol. 2006)
    10. Characterization of the human EDF-1 minimal promoter: involvement of NFY and Sp1 in the regulation of basal transcription. (PubMed id 16567061)1, 9 Bolognese F....Maier J.A. (Gene 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8721 HGNC: 3164 AceView: EDF1 Ensembl:ENSG00000107223 euGenes: HUgn8721
    ECgene: EDF1 H-InvDB: EDF1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for EDF1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EDF1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for EDF1 gene:
    Search GeneIP for patents involving EDF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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