Aliases for EDEM3 Gene
External Ids for EDEM3 Gene
Previous HGNC Symbols for EDEM3 Gene
Previous GeneCards Identifiers for EDEM3 Gene
Quality control in the endoplasmic reticulum (ER) ensures that only properly folded proteins are retained in the cell through recognition and degradation of misfolded or unassembled proteins. EDEM3 belongs to a group of proteins that accelerate degradation of misfolded glycoproteins in the ER (Hirao et al., 2006 [PubMed 16431915]).[supplied by OMIM, Mar 2008]
GeneCards Summary for EDEM3 Gene
EDEM3 (ER Degradation Enhancer, Mannosidase Alpha-Like 3) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Protein processing in endoplasmic reticulum. GO annotations related to this gene include calcium ion binding and glycoprotein endo-alpha-1,2-mannosidase activity. An important paralog of this gene is EDEM2.
UniProtKB/Swiss-Prot for EDEM3 Gene
Involved in endoplasmic reticulum-associated degradation (ERAD). Accelerates the glycoprotein ERAD by proteasomes, by catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2 in the N-glycans. Seems to have alpha 1,2-mannosidase activity (By similarity).